Safety and Efficacy of Melflufen and Dexamethasone in Relapsed and/or Relapsed-Refractory Multiple Myeloma Patients
NCT01897714
Terminated
The study will explore escalating doses of melflufen in combination with dexamethasone in small groups of patients to find the maximum tolerated dose of melflufen. That dose will then be used to determine the efficacy and safety profile of melflufen in combination with dexamethasone in a larger group of patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2020
Locations: Dana Farber Cancer Institute, Boston, Massachusetts +6 locations
Conditions: Relapsed and/or Relapsed-refractory Multiple Myeloma
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Aplidin - Dexamethasone in Relapsed/Refractory Myeloma
NCT01102426
Completed
Study of Plitidepsin in combination with dexamethasone versus dexamethasone alone in patients with relapsed/refractory multiple myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2020
Locations: 1107, Tuscaloosa, Alabama +81 locations
Conditions: Relapsed/Refractory Multiple Myeloma
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Dextenza Within Upper Lid Canaliculus Compared With Lower Lid Canaliculus Following Bilateral Cataract Extraction Surgery With PCIOL.
NCT04592081
Unknown
Assessing DEXTENZA efficacy when placed within the upper eyelid canaliculus as opposed to the lower eyelid canaliculus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2020
Locations: Assil Eye Institute, Beverly Hills, California
Conditions: Post-Surgical Ocular Pain, Post-Surgical Ocular Inflammation
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Phase 1b Study of Weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Multiple Myeloma
NCT02335983
Completed
The purpose of the study is to assess the safety, tolerability and activity of a once-weekly regimen of carfilzomib in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2020
Locations: Research Site, Bakersfield, California +58 locations
Conditions: Multiple Myeloma
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Lenalidomide, Thalidomide and Dexamethasone in Treating Participants With Relapsed or Refractory Multiple Myeloma
NCT00966693
Completed
This phase I/II trial studies the best dose and side effects of lenalidomide and thalidomide, and how well they work with dexamethasone in treating participants with multiple myeloma that has come back or does not respond to treatment. Drugs used in chemotherapy, such as lenalidomide, thalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/12/2020
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
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A Study of ARRY-520 in Patients With Relapsed or Refractory Multiple Myeloma
NCT00821249
Completed
This is a 2-phase study during which patients with relapsed or refractory multiple myeloma (MM) or plasma cell leukemia (PCL), who have already received at least two previous treatments, will receive investigational study drug ARRY-520. The study has 3 parts. In the first part of the study, Phase 1, patients will receive increasing doses of study drug, with or without granulocyte-colony stimulating factor (G-CSF) support, in order to achieve the highest dose possible that will not cause unaccep... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2020
Locations: Emory University, Winship Cancer Institute, Atlanta, Georgia +4 locations
Conditions: Multiple Myeloma, Plasma Cell Leukemia
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Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders
NCT02266433
Terminated
The primary objective of this study is to compare local corticosteroid hand and elbow injections to placebo or ketorolac to determine if there is an equal or better reduction of symptoms for common orthopaedic upper extremity disorders including: De Quervain's tenosynovitis, trigger fingers, and tennis elbow (lateral epicondylitis). The investigators will enroll 780 subjects, divided equally into three arms for each disease process, and compare the efficacy of Ketorolac injections to Dexamethaso... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2020
Locations: New York University School of Medicine, New York, New York
Conditions: DeQuervains Tenosynovitis, Lateral Epicondylitis, Tennis Elbow, Trigger Finger, Tenosynovitis, Inflammatory Disease
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Palonosetron and Dexamethasone With or Without Dronabinol in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy For Cancer
NCT00553059
Completed
The goal of this clinical research study is to learn if adding dronabinol in combination with the standard of care (dexamethasone and palonosetron) can better help to control nausea and vomiting in patients receiving chemotherapy. The safety of the drug combinations will also be studied.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/06/2020
Locations: Cancer Research for the Ozarks, Springfield, Missouri +3 locations
Conditions: Chemotherapy-induced Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific
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A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL
NCT01483690
Terminated
This is a pilot study using decitabine and vorinostat before and during chemotherapy with vincristine, dexamethasone, mitoxantrone, and peg-asparaginase in pediatric patients with acute lymphoblastic leukemia (ALL).
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
10/05/2020
Locations: Childrens Hospital Los Angeles, Los Angeles, California +27 locations
Conditions: Acute Lymphoblastic Leukemia, Precursor B-Cell Lymphoblastic Leukemia, Precursor T-Cell Lymphoblastic Leukemia
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Arsenic Trioxide and Dexamethasone in Treating Patients With Recurrent or Refractory Stage II or Stage III Multiple Myeloma
NCT00017069
Terminated
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combining arsenic trioxide and dexamethasone in treating patients who have recurrent or refractory stage II or stage III multiple myeloma.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
10/02/2020
Locations: Arizona Clinical Research Center, Tucson, Arizona +9 locations
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
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Study of Bendamustine and IXAZOMIB (MLN9708) Plus Dexamethasone in Relapsed/Refractory Multiple Myeloma
NCT02477215
Completed
This Phase I/II study is designed to first identify doses of MLN9708 and bendamustine that are associated with an acceptable adverse event profile when delivered together in 28-day cycles. Additionally, the study aims to assess the efficacy of the combination in patients with relapsed/refractory multiple myeloma. Responders (stable disease or more), will continue to receive up to eight cycles total in the absence of further progressive disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/30/2020
Locations: Froedtert Hospital and the Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Multiple Myeloma
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A Study of ARRY-520 and Bortezomib Plus Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma
NCT01248923
Completed
This is a Phase 1 study during which patients with relapsed or refractory multiple myeloma (MM) or plasma cell leukemia (PCL) will receive investigational study drug ARRY-520 and bortezomib, with or without dexamethasone, with granulocyte-colony stimulating factor (G-CSF) support. This study has 2 parts. In the first part, patients will receive increasing doses of study drug (2 dosing schedules will be evaluated) in combination with (1) bortezomib with G-CSF support or (2) bortezomib and dexame... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/28/2020
Locations: Clearview Cancer Institute, Huntsville, Alabama +12 locations
Conditions: Multiple Myeloma, Plasma Cell Leukemia
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