Lenalidomide and Dexamethasone With or Without Anakinra in Treating Patients With Early Stage Multiple Myeloma
NCT02492750
Completed
This partially randomized phase I/II trial studies the side effects and best dose of anakinra when given together with lenalidomide and dexamethasone in treating patients with early stage multiple myeloma. Biological therapies, such as lenalidomide and anakinra, may stimulate or suppress the immune system in different ways and stop cancer cells from growing. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2020
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Indolent Plasma Cell Myeloma, Plasma Cell Myeloma, Smoldering Plasma Cell Myeloma
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Panobinostat or Placebo With Bortezomib and Dexamethasone in Patients With Relapsed Multiple Myeloma
NCT01023308
Completed
Panobinostat (LBH589) is a highly potent pan-deacetylase inhibitor (pan-DACi), inclusive of HDAC6, which disrupts aggresome function, promotes accumulation of cytotoxic misfolded protein aggregates and triggers myeloma cell death. Combination of pan-DAC and protease inhibition by co-treatment with panobinostat (PAN) and bortezomib (BTZ) has demonstrated synergistic cytotoxicity in vitro and in vivo in pre-clinical experiments. Furthermore, clinical experience in advanced multiple myeloma (MM) pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2020
Locations: Novartis Investigative Site, Phoenix, Arizona +209 locations
Conditions: Multiple Myeloma
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Preoperative Levator Ani Muscle Injection and Pudendal Nerve Block for Pain Control After Vaginal Reconstructive Surgery
NCT03040011
Completed
To test the hypothesis that preoperative injections along the levator ani muscles and pudendal nerve with bupivacaine and dexamethasone improve pain control after vaginal apical reconstructive surgery. A three-arm, double-blinded, randomized controlled trial of a total of 75 women will be performed. The study population will be adult women (\>18 years of age) with uterovaginal or vaginal vault prolapse who have been scheduled for native tissue vaginal reconstructive surgery which includes an ap... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/06/2020
Locations: Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania
Conditions: Pelvic Organ Prolapse, Surgery, Postoperative Pain
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Safety and Effectiveness of Ozurdex Steroid Implants for DME After Vitrectomy Surgery
NCT01788475
Terminated
Currently medications injected intravitreally in previously vitrectomized eyes have a very short half-life due to enhanced clearance of the drug. The use of the Ozurdex (dexamethasone) implant may allow sustained levels of steroid delivery to patients with diabetic macular edema that have undergone prior vitrectomy. The sustained steroid levels may lead to improved central retinal thickness measurements and improved visual acuity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2020
Locations: Lahey Medical Center, One Essex Center Drive, Peabody, Massachusetts
Conditions: Diabetic Macular Edema
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Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Relapsed or Relapsed and Refractory Multiple Myeloma
NCT01478581
Completed
The primary objective of this study is to determine the efficacy of PCI-32765, both as a single agent and in combination with dexamethasone, in subjects with relapsed or relapsed and refractory Multiple Myeloma (MM)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/02/2020
Locations: SITE-13, La Jolla, California +10 locations
Conditions: Multiple Myeloma
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Study Testing Radium-223 Dichloride in Relapsed Multiple Myeloma
NCT02928029
Terminated
This study will be conducted in 2 parts. The phase 1b part will be an international, phase 1b, open-label, dose-escalation assessment of radium-223 dichloride administered with bortezomib and dexamethasone in subjects with relapsed multiple myeloma. The primary endpoint is to determine the optimal dose of radium-223 dichloride in combination with bortezomib/dexamethasone for the Phase 2 portion of the study. The phase 2 part will be an international, phase 2, double-blind, randomized, placebo-c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2020
Locations: Pacific Oncology/Hematology Associates, Encinitas, California +6 locations
Conditions: Multiple Myeloma
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Lower-Limb Adventitial Infusion of DexaMethasone Via Bullfrog to Reduce Occurrence of Restenosis After Atherectomy (ATX)-Based Revascularization
NCT02479620
Unknown
This is a prospective, multi-center, randomized pilot study to document the effects of adventitial delivery of dexamethasone after atherectomy-based revascularizations of lesions below the knee in symptomatic patients with critical limb ischemia (CLI).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2020
Locations: Arkansas Heart Hospital, Little Rock, Arkansas +9 locations
Conditions: Chronic Limb Ischemia
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Bendamustine Hydrochloride, Lenalidomide, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
NCT01049945
Completed
RATIONALE: Drugs used in chemotherapy, such as bendamustine hydrochloride and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. Giving bendamustine hydrochloride together with lenalidomide and dexamethasone may kill more cancer cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2020
Locations: City of Hope, Duarte, California +4 locations
Conditions: Refractory Multiple Myeloma
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Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL)
NCT00440726
Completed
This is a Phase I/II study of a drug called bortezomib given in combination with chemotherapy drugs used to treat acute lymphoblastic leukemia (ALL) that has come back (recurred). Bortezomib is a drug that has been approved by the Food and Drug Administration (FDA) for treating adults with multiple myeloma which is a type of blood cancer. Bortezomib has been shown to cause cancer cells to die in studies done on animals (mice). Studies have been done that have shown that some adults and children... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
02/07/2020
Locations: City of Hope, Duarte, California +23 locations
Conditions: Acute Lymphoblastic Leukemia
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Does Dexamethasone Administration Improve Recovery In Patients Undergoing Minimally Invasive Sacrocolpopexy?
NCT03094442
Withdrawn
The primary aim is to evaluate whether standard administration of Dexamethasone at the time of general anesthesia induction at the time of minimally invasive sacrocolpopexy (MISC) would result in improved quality of recovery (QoR).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/04/2020
Locations: Cleveland Clinic Florida, Weston, Florida
Conditions: Quality of Life, Pelvic Organ Prolapse, Prolapses, Vaginal Vault
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Effects of Dry Eye Treatments on the Ocular Surface
NCT01797822
Completed
The purpose of this study is to evaluate whether, in people with dry eye syndrome, over the counter artificial tears and the prescription eye drop, dexamethasone, change or effect the eyes response to a low humidity environment. It is known that irritation from dry eye can be improved by over the counter artificial tears because they wet and lubricate the eyes. The prescription eye drop, dexamethasone, can also improve eye irritation by decreasing the inflammation that develops in dry eye. Thus... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2020
Locations: Baylor College of Medicine, Alkek Eye Center, Houston, Texas
Conditions: Keratoconjunctivitis Sicca, Dry Eye Syndrome
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Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery
NCT02034019
Completed
To evaluate the safety and efficacy of OTX-DP as a sustained release drug (dexamethasone) depot when placed in the canaliculus of the eyelid for the treatment of post-surgical inflammation and pain in subjects who have undergone cataract extraction with intra-ocular lens implantation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2020
Locations: Texan Eye / Keystone Research, Ltd., Austin, Texas
Conditions: Post Ocular Surgical Inflammation and Pain
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