Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies
NCT02419755
Terminated
This study will test the safety and effectiveness of adding bortezomib and vorinostat to other chemotherapy drugs commonly used to treat relapsed or refractory leukemia. Both drugs have been approved by the Food and Drug Administration (FDA) to treat other cancers in adults, but they have not yet been approved tor treatment younger patients with leukemia. PRIMARY OBJECTIVE * To estimate the overall response rate of patients with MLL rearranged (MLLr) hematologic malignancies receiving bortezom... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
02/05/2018
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Mixed Lineage Acute Leukemia, Acute Myeloid Leukemia, Acute Lymphoid Leukemia
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Dexamethasone and Pain Following Total Knee Arthroplasty
NCT02271698
Completed
The purpose of the study is three fold. First to determine the ideal dose of dexamethasone intraoperatively that will reduce acute pain and opioid consumption. Second determine if dexamethasone at the time of surgery reduces chronic pain following total knee arthroplasty and finally determine if a pro-inflammatory environment makes patients susceptible to chronic pain after surgery and can dexamethasone alter this environment. Patients undergoing total knee arthroplasty will be randomized to fou... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
01/22/2018
Locations: DUMC, Durham, North Carolina
Conditions: Acute Pain, Chronic Pain
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"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
NCT03081416
Completed
This is a randomized, single-blind, placebo controlled trial to evaluate the efficacy of sub-dissociative dose ketamine versus standard care therapy for acute headache management of in patients presenting to the emergency department with headache as the chief compliant.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/16/2018
Locations: Brooke Army Medical Center, San Antonio, Texas
Conditions: Headache, Intranasal Ketamine
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A Study to Determine the Effect and Safety of an Oral Janus Kinase 2 (JAK2)-Inhibitor (Ruxolitinib; INBC018424) in Patients With Multiple Myeloma
NCT00639002
Completed
The purpose of this study was to determine clinical efficacy and safety of ruxolitinib (INCB018424), a small molecule Janus kinase 2 (JAK2)-inhibitor, in patients with refractory or relapsed multiple myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2018
Locations: Not set, Highland, California +2 locations
Conditions: Multiple Myeloma
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Pre-Emptive Analgesia in Ano-Rectal Surgery
NCT02402543
Completed
The perianal region is the region around the anus. Administering a pain medication before a surgery starts is called preemptive analgesia. In some studies, this technique has been shown to be an effective way to reduce the pain that a patient experiences in the post-operative timeframe to a greater extent than would be expected simply from the pain medications alone. One theory of why this occurs suggests that the preemptive analgesia desensitizes brain and nerves to pain, thereby decreasing the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/11/2018
Locations: University of Vermont Medical Center, Burlington, Vermont +1 locations
Conditions: Hemorrhoids, Fissure in Ano, Rectal Fistula, Anal Condyloma
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Dexamethasone Infusion to the Adventitia to Enhance Clinical Efficacy After Femoropopliteal Revascularization
NCT01507558
Completed
The purpose of this study is to test if dexamethasone, an anti-inflammatory medication approved by the US Food and Drug Administration (FDA), can be injected safely into the tissue around the blood vessel wall at the time of an angioplasty or atherectomy.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
01/04/2018
Locations: San Francisco VA Medical Center, San Francisco, California +1 locations
Conditions: Peripheral Arterial Disease
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Induction Therapy Study in Live Donor Kidney Transplant Recipients With a Positive Crossmatch
NCT00275509
Completed
The purpose of this study is to determine whether the anti-T cell antibody, Thymoglobulin is a more effective induction medication than the anti-IL-2R inhibitor daclizumab, in kidney transplant recipients who have a positive crossmatch with their live donor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2017
Locations: The Johns Hopkins University, School of Medicine, Baltimore, Maryland
Conditions: Kidney Failure, Chronic
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A Study Of IV Casopitant For The Prevention Of Chemotherapy Induced Nausea And Vomiting.
NCT00601172
Completed
This a Phase III trial designed to determine if IV casopitant plus dexamethasone and ondansetron is more effective in the prevention of vomiting and nausea then dexamethasone and ondansetrone alone following the administration of moderately emetogenic oxaliplatin-based chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2017
Locations: GSK Investigational Site, Hot Springs, Arkansas +95 locations
Conditions: Nausea and Vomiting, Chemotherapy-Induced
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Dexamethasone as an Immediate Intervention
NCT02753166
Withdrawn
To determine if a single dose of dexamethasone (5 mg) administered in the first 12 hours following a potentially traumatic event alters a) cortisol and FKBP5 RNA the next day in the periphery measured in saliva; b) FKBP5 methylation by 1 month; c) executive functioning and emotion regulation functioning; d) psychophysiological (heart rate, respiration, skin conductance) in response cued reminders of the trauma; e) enhances the likelihood of remission of PTSD symptom severity.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/12/2017
Locations: New York University Medical Center, New York, New York
Conditions: Trauma
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Study Comparing Inotuzumab Ozogamicin In Combination With Rituximab Versus Defined Investigator's Choice In Follicular Non-Hodgkin's Lymphoma (NHL)
NCT00562965
Terminated
This protocol is designed to assess the efficacy and safety of inotuzumab ozogamicin given with rituximab compared to a defined investigator's choice therapy. Subjects will be randomized to one of these two arms of the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/08/2017
Locations: Facey Medical Group, Mission Hills, California +38 locations
Conditions: Lymphoma, Follicular
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Phase I & Biological Study of Etanercept & Weekly Docetaxel in Patients With Advanced Solid Tumors
NCT00201812
Completed
To determine the safety and efficacy of the combination of Etanercept and Docetaxel in patients with advanced solid tumors for which there is no standard treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2017
Locations: Ohio State University Medical Center, Columbus, Ohio
Conditions: Tumors
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Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis
NCT03245671
Withdrawn
Chronic lumbosacral radiculopathy secondary to lumbar spinal stenosis affects a large number of individuals, and there is a general lack of consensus in the medical community in terms of effective treatments for this problem. By assessing the relative efficacy of transforaminal epidural injections of particulate and nonparticulate steroids, this study attempts to further define the appropriate conservative management of painful unilateral radiculopathies due to unilateral lumbar foraminal stenos... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
12/04/2017
Locations: Hospital for Special Surgery, New York, New York
Conditions: Lumbar Spinal Stenosis
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