Bendamustine in Combination With Lenalidomide and Dexamethasone in Refractory or Relapsed Multiple Myeloma
NCT01042704
Completed
The purpose of this study is to see if the combination of bendamustine, lenalidomide and dexamethasone will help people with multiple myeloma that has returned after standard treatment or has been resistant to other treatments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/26/2017
Locations: Karmanos Cancer Institute, Detroit, Michigan +21 locations
Conditions: Myeloma
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Phase 1b/2 Study of Carfilzomib in Relapsed Solid Tumors, Multiple Myeloma, or Lymphoma
NCT00531284
Completed
The primary objectives of this Phase 1b/2 study were as follows: * Phase 1b (Bolus and Infusion): To evaluate the safety and tolerability of carfilzomib in patients with relapsed solid tumors and in patients with relapsed and/or refractory multiple myeloma and in patients with refractory lymphoma. * Phase 2 (Bolus): To evaluate the overall response rate (ORR) after 4 cycles of carfilzomib in patients with relapsed solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2017
Locations: Pinnacle Oncology, Scottsdale, Arizona +6 locations
Conditions: Ovarian Cancer, Renal Cancer, Non-small Cell Lung Cancer, Small Cell Lung Cancer, Solid Tumors, Multiple Myeloma, Lymphoma
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Comparison of Exparel to Bupivacaine With Dexamethasone in TAP Block
NCT02179892
Terminated
The purpose of this study is to compare the efficacy and duration of bupivacaine extended-release liposome injection (Exparel) versus bupivacaine with dexamethasone in transversus abdominis plane (TAP) blocks for patients undergoing abdominal surgery at Emory University Hospital and Emory University Hospital Midtown. The investigators hypothesize that Exparel will provide greater postoperative pain relief than bupivacaine with dexamethasone. The investigators plan to enroll up to 50 male and fe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/13/2017
Locations: Emory University Hospital Midtown, Atlanta, Georgia +1 locations
Conditions: Pain
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RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell Leukemia
NCT01236586
Withdrawn
Background: - The anti-cancer drug RO4929097 is being tested for its ability to block blood vessel growth to tumors and slow or stop the growth of cancer cells. However, it has been used in only a small number of adults and has not yet been tested in children. Researchers are interested in determining whether RO4929097 is a safe and effective treatment for tumors or leukemia that has not responded to standard treatment. Objectives: - To determine the safety and effectiveness of RO4929097 as a... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
06/30/2017
Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland +1 locations
Conditions: Lymphoma, Brain Neoplasms, Sarcoma, Osteosarcoma, Wilm's Tumor
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Effects of Perioperative Intravenous Dexamethasone on Pain in Out Patient Knee Surgery
NCT01149616
Terminated
The purpose of the study is to determine the opiate sparing effects of intravenously administered dexamethasone in outpatient knee surgery. Dexamethasone is a glucocorticoid with well known antiemetic effects. However, the analgesic effects of dexamethasone have not been adequately researched. Following surgery, patients are typically discharged home with PO opiates to manage post-operative pain. The investigators believe that by using VAS (Visual Analog Scale) for Pain the investigators can sho... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/29/2017
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Post Operative Pain, Nausea
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Study of Elotuzumab in Combination With Lenalidomide and Dexamethasone in Subjects With Multiple Myeloma and Various Levels of Renal Function
NCT01393964
Completed
The purpose of the study is to assess the concentration of Elotuzumab in Myeloma patients with very low kidney function including patients on dialysis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2017
Locations: Winship Cancer Institute, Emory University, Atlanta, Georgia +10 locations
Conditions: Multiple Myeloma
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Dexamethasone for Post-cesarean Delivery Pain
NCT01812057
Completed
The purpose of this study is to compare post-cesarean section consumption of pain medication between two groups of patients undergoing scheduled cesarean section at term gestation who receive a single-dose of intraoperative steroid (dexamethasone 8 milligrams) versus placebo at 24 hours after surgery. The hypothesis is that a single perioperative dose of dexamethasone 8 mg will significantly reduce postoperative opioid consumption at 24 h in women having cesarean delivery under spinal anesthesia... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/26/2017
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Pain, Postoperative, Postoperative Nausea and Vomiting
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Thalidomide, Dexamethasone, and Clarithromycin in Treating Patients With Multiple Myeloma Previously Treated With Transplant
NCT00182663
Completed
This phase II trial studies the side effects and how well giving thalidomide, dexamethasone, and clarithromycin together works in treating patients with multiple myeloma previously treated with transplant. Biological therapies, such as thalidomide and clarithromycin, may stimulate the immune system in different ways and stop cancer cells from growing. Dexamethasone also works in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Givi... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
06/22/2017
Locations: Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington
Conditions: Refractory Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
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Combination of Revlimid, Melphalan and Dexamethasone as First Line Treatment for Multiple Myeloma
NCT00843310
Terminated
This study is to determine whether addition of Revlimid to standard therapy will increase overall and complete response rates compared to historical standard frontline therapy and whether this combination treatment has fewer side effects than similar combination induction treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2017
Locations: Bellevue Hospital, New York, New York +2 locations
Conditions: Multiple Myeloma
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Phase II Study of Velcade, Decadron, and Doxil Followed by Cyclophosphamide in Multiple Myeloma
NCT00148317
Completed
PRIMARY STUDY OBJECTIVES * To evaluate the efficacy of the combination of bortezomib, dexamethasone, with and without DOXIL, followed by high-dose cyclophosphamide as a therapy for two different subsets of multiple myeloma patients: 1. Patients post first line therapy 2. Patients with relapsed/refractory disease who are bortezomib-naïve * To evaluate the safety of the combination of bortezomib and dexamethasone, with and without DOXIL, followed by high-dose cyclophosphamide as therapy for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2017
Locations: Weill Medical College of Cornell University, New York, New York
Conditions: Multiple Myeloma
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Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain
NCT02024724
Completed
Trigeminal neuralgia is a craniofacial pain syndrome that is typically characterized by unilateral severe, recurrent, electrical pain in one or more distributions of the trigeminal nerve. Current treatment strategies include oral medications as first line therapy with surgical interventions reserved for those patients who are refractory to medications or unable to tolerate medication side effects. Despite these current treatment options, many patients continue to have symptoms. Ultrasound-guided... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/14/2017
Locations: Anesthesiology Pain Medcine Center, Chicago, Illinois
Conditions: Typical Facial Pain, Atypical Facial Pain
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Evaluating Perioperative Dexamethasone and the Risk of Bleeding in Tonsillectomy
NCT01415583
Completed
Tonsillectomy (removal of the tonsils) is a very common surgery in children. Bleeding after tonsillectomy is one of the risks of this surgery and can be more dangerous in children since they have less blood volume than adults. In order to improve recovery after tonsillectomy, steroids (medication that is a strong anti-inflammatory) are often given during the surgery. Recently, a study showed steroids given at the time of tonsillectomy increase the risk of bleeding significantly over children who... Read More
Gender:
ALL
Ages:
Between 3 years and 18 years
Trial Updated:
06/12/2017
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Post-operative Hemorrhage
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