A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients
NCT03714919
Completed
This proposed study will assess analgesic efficacy of a multi-modal, non-opioid analgesic regimen for providing surgical analgesia in pediatric patients undergoing adenoidectomy and to assess recovery characteristics in the post-anesthesia care unit (PACU) and at home following surgery.
Gender:
ALL
Ages:
Between 4 years and 8 years
Trial Updated:
01/19/2021
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Adenoid Hypertrophy
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Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain
NCT03959852
Terminated
The objective of this study is to evaluate the potential opioid-sparing effect associated with the novel combination of fentanyl and sub-dissociative ketamine in adult patients with moderate to severe pain in the emergency department.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/09/2020
Locations: St. Elizabeth Boardman Hospital, Boardman, Ohio
Conditions: Pain, Acute
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Pain Reduction With Intranasal Medications for Extremity Injuries
NCT02778880
Completed
This study compares the analgesic effect of intranasal sub-dissociative dosing of ketamine and intranasal fentanyl in children presenting to the Emergency Department with acute extremity injuries.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
08/18/2020
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Pain, Traumatic Limb Injury
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Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression
NCT02522377
Completed
In this proof of concept study, the investigators plan to administer iv ketamine interleaved with ECT days. Patients with treatment resistant depression who are deemed to be eligible for ECT treatment will randomly be assigned to either ketamine or active placebo.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/28/2019
Locations: Cleveland Clinic Foundation Center for Behavioral Health, Cleveland, Ohio
Conditions: Treatment Resistant Depression, Major Depressive Disorder, Severe Depression
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Dexmedetomidine and Ketamine in MRI
NCT02652507
Completed
The purpose of this research study is to examine the effects of two commonly used anesthetic drugs, dexmedetomidine and ketamine, have on the shape and muscle tone of the upper airway in children, adolescents, and young adults. The results of this study will help in making the best decisions regarding the anesthesia medications used for sedation outside of the operating room.
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
07/23/2019
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Magnetic Resonance Imaging
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Ketamine for Major Depressive Disorder
NCT03721900
Unknown
The purpose of this study is to measure the amount of ketamine in blood over time in subjects diagnosed with Major Depressive Disorder (MDD) and explore the anti-depressive effects of ketamine delivered by transdermal patch.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/24/2019
Locations: Clinical Research Site, Dayton, Ohio
Conditions: Major Depressive Disorder
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Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain
NCT00720330
Terminated
The investigators are conducting this study to find out if intravenous (injected through the vein) infusion of lidocaine and ketamine administered with general anesthesia is as effective as a paravertebral block in lessening pain after surgery and that both of these techniques are superior to general anesthesia alone in reducing pain immediately after surgery and in the long-term.
Gender:
MALE
Ages:
Between 18 years and 75 years
Trial Updated:
03/08/2019
Locations: Cleveland Clinic/Hillcrest Hospital, Mayfield Heights, Ohio
Conditions: Pain, Nausea
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Study of Intranasal Ketamine for Social Impairment in Autism Spectrum Disorder
NCT02611921
Completed
The purpose of the study is to determine if intranasal ketamine shows initial evidence of safety, tolerability and efficacy for the treatment of social impairment in individuals with Autism Spectrum Disorder.
Gender:
ALL
Ages:
Between 12 years and 30 years
Trial Updated:
10/10/2018
Locations: Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio
Conditions: Autism Spectrum Disorder
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Ketamine Patient-Controlled Analgesia for Acute Pain
NCT02062879
Terminated
This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have similar or improved objective pain scores. Patients receiving ketamine are also expected to have shorter duration of supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary toilet, lower use of antiemetics, and shorter times to first bowe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2017
Locations: University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Acute Pain, Multiple Trauma, Fractures
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Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
NCT00516503
Completed
RATIONALE: Baclofen-amitriptyline-ketamine (BAK) gel may lessen peripheral neuropathy caused by chemotherapy. It is not yet known whether BAK gel is more effective than a placebo in treating peripheral neuropathy caused by chemotherapy . PURPOSE: This randomized phase III trial is studying BAK gel to see how well it works compared with a placebo in treating peripheral neuropathy caused by chemotherapy in patients with cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2017
Locations: Mary Rutan Hospital, Bellefontaine, Ohio +42 locations
Conditions: Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Neurotoxicity, Pain, Unspecified Adult Solid Tumor, Protocol Specific
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Lidocaine and Ketamine in Abdominal Surgery
NCT00721110
Terminated
This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy. Participants will be randomized into one of four groups. Evaluations will be done through walking tests, pain and fatigue questionnaires and blood tests.
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
04/17/2017
Locations: Cleveland Clinic/Hillcrest Hospital, Mayfield Heights, Ohio
Conditions: Abdominal Hysterectomy (& Wertheim)
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Emergency Ketamine Treatment of Suicidal Ideation
NCT02183272
Unknown
The objective of the current program of research will be to test whether intranasal ketamine treatment is more effective than placebo in reducing suicidal ideation in suicidal patients presenting for acute treatment in emergency department settings. Secondary objectives will test the effect of genotypic differences in the mu opioid receptor on efficacy of ketamine and the correlation of speech patterns and facial movement patterns with subjective reductions in suicidal ideation after ketamine tr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/03/2016
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Depression, Suicidal Ideation, Suicidal Impulses
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