Neurobiology of Suicide
Recruiting
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective: To understand what happens in the brain when someone has thought about or attempted suicide. Eligibility: Group 1: Adults ages 18 70 who have thought about or attempted suicide recently Group 2: Adults ages 18 70 who have thought about or... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteers, Depression
Anesthetics and Analgesics in Children
Recruiting
The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
07/29/2025
Locations: Lucile Packard Children's Hospital, Stanford, California +12 locations
Conditions: Anesthesia, Pain
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
Recruiting
This is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
07/23/2025
Locations: Massachusetts General Hospital, Chelsea, Chelsea, Massachusetts
Conditions: Depression
The Dreamy Jet Study
Not Yet Recruiting
The goal of this clinical trial is to see if a device known as a jet-injection system can help deliver a single dose of a sedating medication with less pain and stress than current methods. Participants will receive a dose of the sedative in their arm or thigh before their procedure at the sedation clinic.
Gender:
ALL
Ages:
Between 2 years and 15 years
Trial Updated:
07/22/2025
Locations: University of Wisconsin - Madison, Madison, Wisconsin
Conditions: Sedation, Blood Drawing Procedure, Immunization, IV Placement
Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)
Recruiting
The objectives of this study are to investigate the feasibility, tolerability, and preliminary efficacy of repeated ketamine-assisted psychotherapy sessions in adolescents with severe posttraumatic stress disorder. The study will enroll adolescents with a current diagnosis of posttraumatic stress disorder (PTSD) to complete three intravenous ketamine administrations accompanied by a psychotherapy session over the span of six weeks. All participants will complete an initial set of preparatory ses... Read More
Gender:
ALL
Ages:
Between 15 years and 17 years
Trial Updated:
07/22/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Posttraumatic Stress Disorder
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
Recruiting
The core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a prognostic marker of 4-week treatment outcome. Previous research focused exclusively on KET-induced gamma band potentiation (GBP) in the context of a single infusion. Our study design captures the clinical variation associated with real-world treatment resistant depression (TRD) patients and allows us to analyze the relativ... Read More
Gender:
ALL
Ages:
Between 21 years and 45 years
Trial Updated:
07/17/2025
Locations: Wells Medicine, Houston, Texas +1 locations
Conditions: Healthy, Major Depressive Disorder, Treatment Resistant Depression
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
Completed
The purpose of the study is to examine whether an investigational medication called ketamine is able to improve treatment outcomes for tobacco use disorder when delivered in conjunction with brief motivational enhancement therapy. Participants will receive ketamine assisted motivational enhancement therapy weekly for three weeks and there will be 2 follow up visits. All visits will also consist of questionnaires and saliva samples will be taken. The overall participation will last approximately... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
07/17/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Tobacco Use, Smoking Cessation, Nicotine Dependence
Prehospital Analgesia INtervention Trial (PAIN)
Recruiting
The Prehospital Analgesia INtervention trial (PAIN) is a proposed 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial that will enroll approximately 994 patients at select LITES Network sites. The objective is to perform a prospective, interventional, randomized trial among prehospital trauma patients with compensated shock (SI≥0.9) and an indication for pain management, comparing patient centered outcomes following prehospital administration of ketamine... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: University of California, San Diego, San Diego, California +9 locations
Conditions: Traumatic Injury
Ketamine for Sedation in Severe Traumatic Brain Injury
Suspended
This protocol is for an open-label randomized trial evaluating the safety of using ketamine in combination with propofol for sedation versus the standard of care analgosedation in patients admitted to the intensive care unit with severe traumatic brain injury.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/10/2025
Locations: Brooke Army Medical Center, Fort Sam Houston, Texas
Conditions: Severe Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, Hypertensive
Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
Recruiting
The proposed study is a single-site, randomized, controlled clinical trial (RCT) comparing ketamine-assisted psychotherapy (KAP) to a standard evidence-based regimen of ketamine administered in a medical model without psychotherapy (KET). Eligible study participants will be adults with major depressive disorder (MDD). Adults with MDD will be randomized to KAP or KET in a 1:1 allocation. Each treatment group will receive KAP or KET over a period of four weeks. Measurement of depression severity,... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
07/10/2025
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Major Depressive Disorder
Ketamine HCl Prolonged Release Oral Tablets for CRPS
Not Yet Recruiting
The purpose of this study is to evaluate the efficacy of Ketamine HCl Prolonged Release (PR) tablets in participants with pain due to complex regional pain syndrome (CRPS). Additionally, this trial will explore the feasibility of the trial design through dosing compliance, clinical instruments for safety and quality of life measurements, and pharmacokinetic profile.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
07/10/2025
Locations: Pain Center, Keck Medical Center of University of Southern California, Los Angeles, California
Conditions: Complex Regional Pain Syndromes
Psilocybin vs Ketamine for Alcohol Use Disorder
Recruiting
This study will collect data that measures the effects of a psychedelic intervention on patients struggling with alcohol use disorder (AUD). The study design will be a double blind, randomized, active-comparator trial with two study arms. Subjects randomized to Arm 1 (n=40) will receive individual psychotherapy sessions plus a 30 mg dose of psilocybin. Arm 2 subjects (n=40) will receive individual psychotherapy sessions and a 0.75 mg/kg dose of ketamine.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
07/09/2025
Locations: University of Iowa Health Care, Iowa City, Iowa
Conditions: Alcohol Use Disorder, Alcohol Dependence, Alcohol Abuse