A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight
Active Not Recruiting
The main purpose of this study is to see how orforglipron affects the amount of body fat compared with placebo in participants with obesity or overweight. Participation in the study will last approximately 8 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2025
Locations: Endeavor Clinical Trials, San Antonio, Texas
Conditions: Obesity, Overweight
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Active Not Recruiting
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk. The study will last approximately 2 years may include up to 27 visits.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2025
Locations: Texas Diabetes & Endocrinology, P.A., Austin, Texas +26 locations
Conditions: Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease
A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes
Active Not Recruiting
This study will investigate the safety and efficacy of once daily oral treatment with orforglipron compared with placebo on body weight in adult participants with obesity or overweight and type 2 diabetes. The study will last about 77 weeks and may include up to 22 visits.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2025
Locations: Velocity Clinical Research, Dallas, Dallas, Texas +5 locations
Conditions: Obesity, Overweight, Type 2 Diabetes
A Drug-Drug Interaction (DDI) Study of Orforglipron With Carbamazepine in Healthy Participants
Completed
The main purpose of this study is to assess the effect of carbamazepine on the amount of orforglipron in the bloodstream and how long it takes the body to get rid of orforglipron when given orally in healthy study participants. The safety and tolerability of orforglipron and carbamazepine when given separately or together will also be evaluated. The study may last up to approximately 77 days for each participant.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
07/25/2024
Locations: ICON Early Phase Services, San Antonio, Texas
Conditions: Healthy