Thymalfasin (Thymosin Alpha 1; Ta1) as an Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 Vaccine
Recruiting
The goal of this research is to learn more about ZADAXIN® (trade name; thymalfasin generic; Ta1 for short) and determine if Ta1 has any benefit in increasing the immune response to the COVID-19 vaccine. Ta1 has been shown to stimulate the immune system to fight infections. This research study will test the safety and possible harms of Ta1 when it is given to people at different dose levels before COVID-19 vaccination.
Gender:
ALL
Ages:
Between 65 years and 100 years
Trial Updated:
07/30/2025
Locations: Houston Methodist Hospital, Houston, Texas
Conditions: Vaccine Response, COVID-19 Vaccine, Immune Response to Covid 19 Vaccination
A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial Infarction
Withdrawn
The objective of this study is to evaluate the safety and tolerability of two active doses of RGN-352 (thymosin beta 4, Tβ4, Injectable Solution) in patients with acute myocardial infarction receiving percutaneous coronary intervention angioplasty with or without stent placement. Approximately 75 subjects will be randomized to receive one of two RGN-352 doses of 1200 mg, or 450 mg, or placebo, administered iv by iv push daily for the first 3 consecutive days and weekly for 4 more weeks.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/15/2021
Locations: St. Vincent Indianapolis Hospital, Indianapolis, Indiana +1 locations
Conditions: Acute Myocardial Infarction, ST Elevation Myocardial Infarction, STEMI
A Phase 1 Safety Study of the Intravenous Administration of Thymosin Beta in Healthy Volunteers
Withdrawn
The purpose of this study is to determine whether the intravenous administration of single- and multiple-ascending doses of Thymosin Beta 4 is safe and tolerable in healthy volunteers.
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
04/13/2017
Locations: Healthcare Discoveries LLC, San Antonio, Texas
Conditions: Myocardial Infarction, Myocardial Ischemia
Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye
Completed
Severe dry eye is a debilitating ocular disease resulting in loss of vision, reduced day-to-day function and significant discomfort. Tear substitutes are an important part of the treatment of all patients, however, even with aggressive us, the corneal(ocular)surface often remains very irregular due to poor surface healing. The agent being evaluated in this study, Thymosin Beta 4, promotes healing of the corneal surface and has been studied in patients with recalcitrant corneal ulcers and erosio... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
12/21/2015
Locations: Michigan Cornea Consultants, P.C., Southfield, Michigan
Conditions: Dry Eye, Sjogren's Syndrome, Graft vs. Host Disease
A Phase 2 Study of the Safety and Efficacy of Thymosin Beta 4 for Treating Corneal Wounds
Terminated
As a consequence of damage to multiple organ systems throughout the course of their disease, diabetic patients suffer a number of chronic complications giving rise to increased morbidity, mortality, and health care costs specific to this population. Within the ophthalmic domain, diabetic retinopathy (DR) frequently induces serious visual impairment. Although DR can be addressed surgically, surgery remains a less than ideal intervention within this population with a well-characterized compromised... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/10/2015
Locations: United Medical Research Institute, Inglewood, California +4 locations
Conditions: Diabetes
Study of Thymosin Beta 4 in Patients With Pressure Ulcers
Completed
The purpose of this study is to evaluate the safety, tolerability and effectiveness of Thymosin Beta 4 administered topically in patients with Pressure Ulcers
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/06/2010
Locations: Institute for Advanced Wound Care, Montgomery, Alabama +11 locations
Conditions: Pressure Ulcers
Thymosin Plus PEG-Interferon in Hepatitis C Patients With Cirrhosis Who Did Not Respond to Interferon or Interferon Plus Ribavirin
Completed
Chronic hepatitis C infection is one of the leading causes of chronic liver disease in the United States. Approximately one-third of patients with hepatitis C infection develop cirrhosis of the liver, which can lead to liver failure or liver cancer. The current treatment for hepatitis C infection in previously untreated patients is successful in only about half of patients. There is no established therapy for non-responders. This is a randomized, double-blinded, multicenter trial to determine t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2008
Locations: University of Alabama - Knollwood Physician's Group, Mobile, Alabama +55 locations
Conditions: Hepatitis C, Hepatitis C, Chronic
Thymosin Plus PEG-Interferon in Non-Cirrhotic Hepatitis C Patients Who Did Not Respond to Interferon or Interferon Plus Ribavirin
Completed
Chronic hepatitis C infection is one of the leading causes of chronic liver disease in the United States. Approximately one-third of patients with hepatitis C infection develop cirrhosis of the liver, which can lead to liver failure or liver cancer. The current treatment for hepatitis C infection in previously untreated patients is successful in only about half of patients. There is no established therapy for non-responders. This is a randomized, double-blinded, multicenter trial to determine t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2008
Locations: University of Alabama - Knollwood Physician's Group Bldg., Mobile, Alabama +47 locations
Conditions: Hepatitis C, Hepatitis C, Chronic
A Trial of Thymalfasin in Adult Patients With Hepatocellular Carcinoma
Completed
The objective of this Phase II trial is to compare the efficacy and safety of 6 months of treatment with thymalfasin plus trans arterial chemoembolization (TACE) with TACE alone in adult patients with non-surgical hepatocellular carcinoma (HCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2008
Locations: California Pacific Medical Center, San Francisco, California +4 locations
Conditions: Carcinoma, Hepatocellular