PLX3397, Radiation Therapy, and Antihormone Therapy in Treating Patients With Intermediate- or High-Risk Prostate Cancer
NCT02472275
Completed
This phase I trial studies the side effects and best dose of multitargeted tyrosine kinase inhibitor PLX3397 (PLX3397) when given together with radiation therapy and antihormone therapy in treating patients with prostate cancer that is at intermediate or high risk of spreading. Multitargeted tyrosine kinase inhibitor PLX3397 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth, and may also help the radiation therapy work better. Radiation therapy uses high-e... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/04/2020
Locations: Wayne State University/Karmanos Cancer Institute, Detroit, Michigan +2 locations
Conditions: Stage I Prostate Adenocarcinoma, Stage II Prostate Adenocarcinoma, Stage III Prostate Adenocarcinoma
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Safety and Efficacy Study of a Testosterone Eye Drop for the Treatment of Meibomian Gland Dysfunction
NCT00755183
Completed
The objective of this study is to assess the safety and efficacy of testosterone 0.03% ophthalmic solution compared to vehicle for the treatment of meibomian gland dysfunction.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
09/29/2020
Locations: Ophthalmic Research Associates, Andover, Massachusetts
Conditions: Meibomian Gland Dysfunction
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Bone Loss in Women With Anorexia Nervosa
NCT00089843
Completed
Women with Anorexia Nervosa have been found to have low bone density. The study will determine whether administration of low doses of a natural hormone, testosterone and/or risedronate, a medication to help prevent bone breakdown will improve or prevent bone loss in this condition.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/31/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anorexia Nervosa
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Hormonal Factors in the Treatment of Anorexia Nervosa
NCT01121211
Completed
The investigators are investigating whether a hormone that is naturally produced by the human body, called testosterone, can help improve weight, disordered eating, depression, and anxiety. The investigators hypothesize that testosterone will be a novel and effective endocrine-targeted therapy for patients with anorexia nervosa.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/31/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anorexia Nervosa, Eating Disorder, Anxiety, Depression
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TEAM: Testosterone Supplementation and Exercise in Elderly Men
NCT00112151
Completed
The purpose of this study is to evaluate the effects of testosterone supplementation (AndroGel) on body composition, strength, endurance, cognition, and function in older men.
Gender:
MALE
Ages:
60 years and above
Trial Updated:
08/19/2020
Locations: University of Colorado Health Sciences Center, Denver, Colorado
Conditions: Healthy
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Docetaxel or Abiraterone Acetate With ADT in Treating Patients With Metastatic Hormone Sensitive Prostate Cancer
NCT03827473
Terminated
This phase II trial studies how well docetaxel or abiraterone acetate work when combined with androgen deprivation therapy (ADT) in treating patients with hormone sensitive prostate cancer that has spread to other parts of the body. Drugs used in chemotherapy, such as docetaxel and abiraterone acetate, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Antihormone therapy, such as ADT may less... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/05/2020
Locations: Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Conditions: Castration-Sensitive Prostate Carcinoma, Metastatic Prostatic Adenocarcinoma, Stage IV Prostate Cancer, Stage IVA Prostate Cancer, Stage IVB Prostate Cancer
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Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment
NCT02408445
Completed
This research study in infant males with Klinefelter syndrome (47,XXY) will learn more about body composition (muscle and fat) and male hormones and look at the effect of testosterone shots on body composition. The Investigators know that older boys and men with Klinefelter syndrome often have more fat compared to muscle than adults without Klinefelter syndrome, but we do not know if this difference is present at birth or develops over time. The Investigators will learn if body composition and m... Read More
Gender:
MALE
Ages:
Between 42 days and 108 days
Trial Updated:
04/02/2020
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Klinefelter Syndrome
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Intranasal Delivery of Testosterone and Its Effect on Doping Markers
NCT02611154
Completed
Hypothesis: Intranasal administration of exogenous testosterone results in a characteristic profile during anti-doping testing, which is different than the profile seen when testosterone is administered into muscle, on skin or under the tongue. Objective: The investigators aim to characterize the unique steroid doping profile following administration of intranasal testosterone to healthy, active volunteer subjects.
Gender:
MALE
Ages:
Between 18 years and 35 years
Trial Updated:
01/29/2020
Locations: University of Utah Orthopaedic Center, Salt Lake City, Utah
Conditions: Abuse of Anabolic Steroids
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ITT-5 Mechanisms of Spermatogenesis in Man
NCT02147964
Withdrawn
The purpose of this investigational drug study is to determine how much male hormone, testosterone, is needed to maintain sperm production in the testis.
Gender:
MALE
Ages:
Between 18 years and 55 years
Trial Updated:
12/16/2019
Locations: University of Washington Medical Center (Health Sciences), Seattle, Washington
Conditions: Gonadotropin Deficiency
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Assessment of the Treatment of Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation
NCT00675714
Terminated
The purpose of the program is to study and characterize the outcome of burn injury with particular attention to improving the rehabilitation of burn survivors, including children. Various agents are assessed for effectiveness on long term burn outcome, such as growth hormone, oxandrolone, propranolol,ketoconazole, inhospital exercise and home exercise.
Gender:
ALL
Ages:
80 years and below
Trial Updated:
11/26/2019
Locations: University of Texas Medical Branch, Galveston, Texas
Conditions: Burns
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Effect of Testosterone Replacement on Exercise Capacity in Hypogonadal Men After a Recent Myocardial Infarction
NCT02803073
Withdrawn
The purpose of this study is to determine the effects of testosterone replacement in hypogonadal men on exercise tolerance and cardiac rehabilitation after an acute myocardial infarction.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/19/2019
Locations: Mission Fitness-Medical Center Hospital, Odessa, Texas
Conditions: Hypogonadism, Acute Myocardial Infarction: Rehabilitation Phase
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Testosterone Treatment for Multiple Sclerosis
NCT00405353
Completed
Since men are less likely to develop multiple sclerosis, the hypothesis was that testosterone might be protective in MS. Men with MS for followed untreated for 6 months, followed by a 12 month treatment period with Androgel.
Gender:
MALE
Ages:
Between 18 years and 65 years
Trial Updated:
11/04/2019
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Multiple Sclerosis
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