There are currently 37 active clinical trials seeking participants for Cardiovascular Diseases research studies. The states with the highest number of trials for Cardiovascular Diseases participants are .
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
NCT03142152
Recruiting
The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating heart failure with functional regurgitation (FMR).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Dignity Health Research Institute at Mercy Gilbert and Chandler Regional Medical Centers, Gilbert, Arizona +70 locations
Conditions: Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
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A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
NCT07064473
Recruiting
This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empagliflozin, helps reduce cardiovascular risk in people with these conditions. The study will compare this combination to a placebo version of vicadrostat with empagliflozin. Participants are put into 2 gro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +1056 locations
Conditions: Diabetes Mellitus, Type 2, Hypertension, Cardiovascular Diseases
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Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation
NCT06061822
Recruiting
Cardiac MRI (CMR) scanning allows doctors to create detailed images of the heart. However, the need for experienced cardiac radiographers to perform each scan can make CMR's delivery difficult, and some patients in the UK wait more than half a year for a scan. These radiographers must take pictures of different part of the heart, termed "views", each of which must be precisely positioned. The investigators believe they can revolutionise CMR, by using artificial intelligence to automatically pos... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Imperial College Healthcare NHS Trust, London, Not set
Conditions: Cardiovascular Diseases, Healthy Volunteers
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SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
NCT05198674
Recruiting
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be collected from eligible subjects previously treated in the SPYRAL PIVOTAL-SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED studies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama +99 locations
Conditions: Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
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Effects of Milk-based Drinks on Gut Microbiome, Sleep and Cardiometabolic Markers
NCT07071181
Recruiting
The purpose of this study is to evaluate the effects of kefir on gastrointestinal health, sleep quality, and biochemical parameters in adults who have sleep problems. Further measurements of cognitive function, arterial stiffness and blood pressure will also be assessed. The following questions will be addressed during the study: 1. What effect does repeated ingestion of kefir have on the gut microbiome and can this positively influence sleep performance (quality and duration) in adults with s... Read More
Gender:
ALL
Ages:
Between 40 years and 70 years
Trial Updated:
07/09/2025
Locations: University of Leeds, Leeds, West Yorkshire +1 locations
Conditions: Sleep, Cardiovascular Diseases, Gut Microbiome, Cognitive Function and Mood, LDL Cholesterol
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Computed Tomography Coronary Angiography for the Prevention of Myocardial Infarction (The SCOT-HEART 2 Trial)
NCT03920176
Recruiting
It is hypothesised that, in individuals being considered for cardiovascular preventative therapy, computed tomography coronary angiography guided management will reduce the future risk of coronary heart disease death or non-fatal myocardial infarction compared to management guided by the current standard of care, a cardiovascular risk score.
Gender:
ALL
Ages:
Between 40 years and 70 years
Trial Updated:
06/30/2025
Locations: Western General Hospital, Edinburgh, City Of Edinburgh
Conditions: Cardiovascular Diseases
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Machine Learning in Quantitative Stress Echocardiography
NCT04193475
Recruiting
Greater diagnostic accuracy is required to find out who is at risk of a heart attack as this can reduce the requirement of more invasive downstream tests and thereby improve the patient experience and also reduce their exposure to risk. Stress echocardiography is a routine clinical test that involves using ultrasound to image the heart whilst it is under stress to assess the risk of a heart attack. This study will focus on developing more accurate analysis tools to interpret the results of thes... Read More
Gender:
ALL
Ages:
Between 20 years and 89 years
Trial Updated:
05/21/2025
Locations: Castle Hill Hospital, Cottingham, Not set
Conditions: Cardiovascular Diseases, Ischaemic Heart Disease
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Mayo AVC Registry and Biobank
NCT03049254
Recruiting
Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as the disease process can be subtle, but sufficient enough, so that the first event is sudden death. The Mayo Clinic AVC Registry is a collaboration between Mayo Clinic, Rochester, USA and Papworth Hospital, Cambridg... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/31/2025
Locations: Mayo Clinic, Rochester, Minnesota +1 locations
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases, Sudden Cardiac Arrest, Sudden Cardiac Death, Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Ventricular Cardiomyopathy, Familial Dilated Cardiomyopathy, Cardiovascular Abnormalities, Sarcoidosis, Cardiac Arrhythmia, Cardiac Sarcoidosis, Myocarditis, Inflammatory Cardiomyopathy, Ventricular Tachycardia, Right Ventricular Outflow Tract Ventricular Tachycardia
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Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)
NCT05996120
Recruiting
In order to perform heart surgery, a machine called cardiopulmonary bypass (CPB), or more commonly known as a heart-lung machine, is used to maintain the circulation of oxygenated blood needed by the rest of the body and its organs. Historically, when a patient is connected to CPB, their body is cooled below the normal body temperature. This is known as hypothermia. This is because scientific studies have previously shown that reduced body temperature lowers metabolism and therefore offers more... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, Leicestershire +10 locations
Conditions: Ischemic Heart Disease, Valvular Heart Disease, Cardiovascular Diseases, Surgery-Complications
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EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
NCT03987633
Recruiting
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the extent and basis of treatment failure in different patient populations. The vast majority of drug registration clinical trials have under-representation of ethnic minority populations. In addition, the wider Caucasian populations have reasonably different clinical characte... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
03/05/2025
Locations: Future Genetics, The Science Centre, Wolverhampton Science Park, Wolverhampton, West Midlands
Conditions: Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure, Hypertension, Peripheral Arterial Disease, Stroke, Ischemic, Asthma, Chronic Obstructive Pulmonary Disease, Obesity, Cancer, Chronic Kidney Diseases, Diabetes Mellitus, Dementia, Depression, Epilepsy, Mental Health Disorder, Rheumatoid Arthritis, Blood Pressure, Breast Cancer Risk, Prostate Cancer, Lung Cancers
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The CACHE Study: Coronary Artery Care in HaEmophilia
NCT06706206
Recruiting
The investigators will use state-of-the-art imaging to look at heart disease in people with haemophilia. Haemophilia is an inherited disorder in which blood does not clot properly because of lack of a key 'glue' blood component (chemicals known as factor VIII or IX). People with haemophilia are 40% less likely to die of heart disease, but it is not known exactly why this is. Understanding heart disease in people with haemophilia is important because better treatments for haemophilia mean that th... Read More
Gender:
MALE
Ages:
Between 45 years and 120 years
Trial Updated:
03/04/2025
Locations: Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire
Conditions: Haemophilia, Cardiovascular Diseases
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Inherited Cardiac cONditions In Kids
NCT05158738
Recruiting
All patients with heart disease should have the opportunity to participate in research into their condition, to advance knowledge and treatment. The investigators have built an online registry and database - The Heart Hive - to connect research-willing participants (with heart muscle disease) with active researchers and projects. Participants enrol and upload their own data through the website.This study uses The Heart Hive platform to study cardiomyopathies - heart muscle disease. These are pro... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/03/2025
Locations: Royal Brompton Hospital, London, Not set +2 locations
Conditions: Inherited Cardiac Conditions, Cardiovascular Diseases
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