Coronary Artery Disease Clinical Trials in United Kingdom

A listing of 29 Coronary Artery Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 29 active clinical trials seeking participants for Coronary Artery Disease research studies. The states with the highest number of trials for Coronary Artery Disease participants are .

Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)

NCT06181240

Recruiting

The FRACTURE Trial is a prospective, non-randomized, single-arm, multicenter, interventional study in US and international centers.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/25/2025

Locations: Scripps Health, La Jolla, California +33 locations

Scripps Health, La Jolla, California

Riverside Community Hospital, Riverside, California

Los Robles Hospital & Medical Center, Thousand Oaks, California

Medical Center of the Rockies, Loveland, Colorado

The Cardiac & Vascular Institute, Gainesville, Florida

HCA FL Memorial Hospital, Jacksonville, Florida

HCA Florida Largo Hospital, Largo, Florida

Northeast Georgia Medical Center, Gainesville, Georgia

Wellstar Research Institute, Hiram, Georgia

Brigham and Women's Hospital, Boston, Massachusetts

Massachusetts General Hospital, Boston, Massachusetts

Trinity Health Michigan Heart, Ypsilanti, Michigan

North Mississippi Medical Center, Tupelo, Mississippi

Montefiore Medical Center, Bronx, New York

The Icahn School of Medicine at Mt. Sinai, New York, New York

Nyph/Cuimc, New York, New York

Tristar Centennial Medical Center, Nashville, Tennessee

Methodist Healthcare Methodist Research Institute, San Antonio, Texas

Chippenham Johnson Willis Hospital, Richmond, Virginia

Onze-Lieve-Vrouwziekenhuis, afgekort OLV ziekenhuis, Aalst, Not set

Aarhus University Hospital, Aarhus, Not set

Segeberger Kliniken GmbH,, Bad Segeberg, Not set

SJG St. Paulus GmbH, St.-Johannes-Hospital Dortmund, Dortmund, Not set

Cellitinnen Krankenhaus St. Vinzenz, Köln, Not set

Klaipeda University Hospital, Klaipėda, Not set

Vilnius University Hospital Santaros Klinikos, Vilnius, Not set

Amsterdam University Medical Center, Amsterdam, Not set

Erasmus Medical Center, Rotterdam, Not set

Harefield Hospital, Harefield, Not set

Royal Free Hospital, London, Not set

St. Thomas' Hospital, London, Not set

King's College Hospital, London, Not set

St George's University of London, London, Not set

Royal Brompton Hospital, London, Not set

Conditions: Coronary Artery Disease, Coronary Artery Calcification

Learn More ›

Product Surveillance Registry

NCT01524276

Recruiting

The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products. The Registry data is intended to benefit and support interests of patients, hospitals, clinicians, regulatory bodies, payers, and industry by streamlining the clinical surveillance process and facilitating leading edge performance assessment via the least burdensome approach.

Gender:

ALL

Ages:

All

Trial Updated:

07/24/2025

Locations: Not set, Birmingham, Alabama +381 locations

Not set, Birmingham, Alabama

Not set, Huntsville, Alabama

Not set, Chandler, Arizona

Not set, Phoenix, Arizona

Not set, Little Rock, Arkansas

Not set, Aliso Viejo, California

Not set, Chula Vista, California

Not set, Colton, California

Not set, La Jolla, California

Not set, Los Angeles, California

Not set, Napa, California

Not set, Redwood City, California

Not set, Salinas, California

Not set, San Diego, California

Not set, Stanford, California

Not set, Torrance, California

Not set, Ventura, California

Not set, Aurora, Colorado

Not set, Colorado Springs, Colorado

Not set, Lakewood, Colorado

Not set, Darien, Connecticut

Not set, Hartford, Connecticut

Not set, New Haven, Connecticut

Not set, Washington, District of Columbia

Not set, Bradenton, Florida

Not set, Clearwater, Florida

Not set, Davie, Florida

Not set, Jacksonville, Florida

Not set, Naples, Florida

Not set, Panama City, Florida

Not set, Safety Harbor, Florida

Not set, Sarasota, Florida

Not set, Weston, Florida

Not set, Gainesville, Georgia

Not set, Chicago, Illinois

Not set, Evansville, Indiana

Not set, Indianapolis, Indiana

Not set, Iowa City, Iowa

Not set, West Des Moines, Iowa

Not set, Kansas City, Kansas

Not set, Edgewood, Kentucky

Not set, Louisville, Kentucky

Not set, New Orleans, Louisiana

Not set, Hyattsville, Maryland

Not set, Salisbury, Maryland

Not set, Silver Spring, Maryland

Not set, Boston, Massachusetts

Not set, Holyoke, Massachusetts

Not set, Ann Arbor, Michigan

Not set, Bay City, Michigan

Not set, Lansing, Michigan

Not set, Rochester Hills, Michigan

Not set, Ypsilanti, Michigan

Not set, Coon Rapids, Minnesota

Not set, Minneapolis, Minnesota

Not set, Robbinsdale, Minnesota

Not set, Rochester, Minnesota

Not set, Saint Cloud, Minnesota

Not set, Jackson, Mississippi

Not set, Columbia, Missouri

Not set, Kansas City, Missouri

Not set, St. Louis, Missouri

Not set, Omaha, Nebraska

Not set, Lebanon, New Hampshire

Not set, Camden, New Jersey

Not set, Marlton, New Jersey

Not set, Morristown, New Jersey

Not set, Ocean Township, New Jersey

Not set, Teaneck, New Jersey

Not set, Albuquerque, New Mexico

Not set, Albany, New York

Not set, Bay Shore, New York

Not set, Huntington, New York

Not set, Manhasset, New York

Not set, Mount Kisco, New York

Not set, New Hyde Park, New York

Not set, New York, New York

Not set, Poughkeepsie, New York

Not set, Riverhead, New York

Not set, Roslyn, New York

Not set, Staten Island, New York

Not set, Stony Brook, New York

Not set, Utica, New York

Not set, Chapel Hill, North Carolina

Not set, Charleston, North Carolina

Not set, Durham, North Carolina

Not set, Pinehurst, North Carolina

Not set, Raleigh, North Carolina

Not set, Winston Salem, North Carolina

Not set, Cleveland, Ohio

Not set, Columbus, Ohio

Not set, Dayton, Ohio

Not set, Mount Orab, Ohio

Not set, Portland, Oregon

Not set, Allentown, Pennsylvania

Not set, Bethlehem, Pennsylvania

Not set, Danville, Pennsylvania

Not set, Erie, Pennsylvania

Not set, Lancaster, Pennsylvania

Not set, Mechanicsburg, Pennsylvania

Not set, Pittsburgh, Pennsylvania

Not set, Wilkes-Barre, Pennsylvania

Not set, Charleston, South Carolina

Not set, Columbia, South Carolina

Not set, Orangeburg, South Carolina

Not set, Spartanburg, South Carolina

Not set, Sioux Falls, South Dakota

Not set, Germantown, Tennessee

Not set, Memphis, Tennessee

Not set, Nashville, Tennessee

Not set, Austin, Texas

Not set, Dallas, Texas

Not set, Ft. Worth, Texas

Not set, Houston, Texas

Not set, Kyle, Texas

Not set, Plano, Texas

Not set, San Antonio, Texas

Not set, Tyler, Texas

Not set, Salt Lake City, Utah

Not set, Burlington, Vermont

Not set, Charlottesville, Virginia

Not set, Fairfax, Virginia

Not set, Fredericksburg, Virginia

Not set, Bremerton, Washington

Not set, Seattle, Washington

Not set, Spokane, Washington

Not set, Morgantown, West Virginia

Not set, Madison, Wisconsin

Not set, Milwaukee, Wisconsin

Not set, Buenos Aires, Not set

Not set, Westmead, New South Wales

Not set, Chermside, Not set

Not set, Murdoch, Not set

Not set, Southport, Not set

Not set, Innsbruck, Not set

Not set, Linz, Not set

Not set, Aalst, Not set

Not set, Brugge, Not set

Not set, Brussel, Not set

Not set, Edegem, Not set

Not set, Genk, Not set

Not set, Gent, Not set

Not set, Leuven, Not set

Not set, Liege, Not set

Not set, Roeselare, Not set

Not set, Sint-Niklaas, Not set

Not set, São Paulo, Not set

Not set, Calgary, Alberta

Not set, Kingston, Ontario

Not set, Montreal, Quebec

Not set, Quebec City, Not set

Not set, Quebec, Not set

Not set, Toronto, Not set

Not set, Chengdu, Sichuan

Not set, Beijing, Not set

Not set, Chengdu, Not set

Not set, Dalian, Not set

Not set, Guangzhou, Not set

Not set, Hangzhou, Not set

Not set, Harbin, Not set

Not set, Kunming, Not set

Not set, Nanchang, Not set

Not set, Shanghai, Not set

Not set, Suzhou, Not set

Not set, Medellin, Not set

Not set, Pereira, Not set

Not set, Rionegro, Not set

Not set, Praha, Not set

Not set, Hellerup, Not set

Not set, Hillerød, Not set

Not set, Kobenhavn, Not set

Not set, Odense, Not set

Not set, Helsinki, Not set

Not set, Tampere, Not set

Not set, Avignon, Not set

Not set, Bordeaux, Not set

Not set, Boulogne-Billancourt, Not set

Not set, Brest Cedex, Not set

Not set, Caen, Not set

Not set, Chambray, Not set

Not set, Clermont Ferrand, Not set

Not set, Créteil, Not set

Not set, Dijon, Not set

Not set, La Rochelle, Not set

Not set, La Tronche, Not set

Not set, Lille Cedex, Not set

Not set, Marseille Cedex 5, Not set

Not set, Montpellier Cedex 5, Not set

Not set, Nantes, Not set

Not set, Ollioules, Not set

Not set, Paris, Not set

Not set, Pessac, Not set

Not set, Pringy, Not set

Not set, Rennes, Not set

Not set, Saint-Priest-en-Jarez, Not set

Not set, Strasbourg, Not set

Not set, Toulouse Cedex 9, Not set

Not set, Villeurbanne, Not set

Not set, Aachen, Not set

Not set, Arnsberg, Not set

Not set, Bad Oeynhausen, Not set

Not set, Berlin, Not set

Not set, Bochum, Not set

Not set, Bremen, Not set

Not set, Düsseldorf, Not set

Not set, Freiburg, Not set

Not set, Hagen, Not set

Not set, Halle (Saale), Not set

Not set, Hamburg, Not set

Not set, Hannover, Not set

Not set, Heidelberg, Not set

Not set, Jena, Not set

Not set, Karlsruhe, Not set

Not set, Köln, Not set

Not set, Leipzig, Not set

Not set, Lübeck, Not set

Not set, Munster, Not set

Not set, München, Not set

Not set, Stuttgart, Not set

Not set, Tubingen, Not set

Not set, Ulm, Not set

Not set, Wiesbaden, Not set

Not set, Athens, Not set

Not set, Maroúsi, Not set

Not set, Thessaloníki, Not set

Not set, Hong Kong, Not set

Not set, Budapest, Not set

Not set, Hyderabad, Telangana

Not set, Bangalore, Not set

Not set, Bengaluru, Not set

Not set, Chennai, Not set

Not set, Gurugram, Not set

Not set, New Delhi, Not set

Not set, Galway, Not set

Not set, Ashkelon, Not set

Not set, Be'er Sheva, Not set

Not set, Jerusalem, Not set

Not set, Ramat Gan, Not set

Not set, Acquaviva Delle Fonti, Not set

Not set, Ancona, Not set

Not set, Bari, Not set

Not set, Bologna, Not set

Not set, Brescia, Not set

Not set, Caserta, Not set

Not set, Castrovillari, Not set

Not set, Cotignola, Not set

Not set, Lecce, Not set

Not set, Milano, Not set

Not set, Modena, Not set

Not set, Monza, Not set

Not set, Palermo, Not set

Not set, Pisa, Not set

Not set, Roma, Not set

Not set, Rome, Not set

Not set, Taranto, Not set

Not set, Udine, Not set

Not set, Sakai, Osaka

Not set, Ageo, Saitama

Not set, Hidaka, Saitama

Not set, Koshigaya, Saitama

Not set, Tokyo, Tachikawa

Not set, Bunkyō-Ku, Tokyo

Not set, Minato-Ku, Tokyo

Not set, Yonago, Tottori

Not set, Chiba, Not set

Not set, Fukui, Not set

Not set, Fukuoka, Not set

Not set, Gifu, Not set

Not set, Hirosaki, Not set

Not set, Hiroshima City, Not set

Not set, Hiroshima, Not set

Not set, Kagoshima, Not set

Not set, Kamakura, Not set

Not set, Kawasaki, Not set

Not set, Kitakyushu, Not set

Not set, Kofu, Not set

Not set, Kumamoto, Not set

Not set, Kyoto, Not set

Not set, Mitaka, Not set

Not set, Nagoya, Not set

Not set, Niigata, Not set

Not set, Okayama, Not set

Not set, Sapporo, Not set

Not set, Shinagawa-Ku, Not set

Not set, Shizuoka, Not set

Not set, Suita, Not set

Not set, Tokyo, Not set

Not set, Toyoake, Not set

Not set, Urasoe, Not set

Not set, Yokohama, Not set

Not set, Ōsaka-sayama, Not set

Not set, Yangsan, Gyeongsangnam-do

Not set, Busan, Not set

Not set, Changwon, Not set

Not set, Cheongju-si, Not set

Not set, Daegu, Not set

Not set, Daejeon, Not set

Not set, Gangneung, Not set

Not set, Gwangju, Not set

Not set, Gyeonggi-do, Not set

Not set, Incheon, Not set

Not set, Jeonju, Not set

Not set, Seongnam-si, Not set

Not set, Seoul, Not set

Not set, Suwon-si, Not set

Not set, Kuwait, Not set

Not set, Kuala Lumpur, Not set

Not set, Ciudad de mexico, Not set

Not set, Den Haag, Not set

Not set, Doetinchem, Not set

Not set, Eindhoven, Not set

Not set, Enschede, Not set

Not set, Groningen, Not set

Not set, Heerlen, Not set

Not set, Hengelo, Not set

Not set, Leiden, Not set

Not set, Maastricht, Not set

Not set, Nieuwegein, Not set

Not set, Rotterdam, Not set

Not set, Christchurch, Not set

Not set, Bergen, Not set

Not set, Lorenskog, Not set

Not set, Trondheim, Not set

Not set, Panama, Not set

Not set, Poznań, Not set

Not set, Warszawa, Not set

Not set, Zabrze, Not set

Not set, Carnaxide, Not set

Not set, Creixomil, Not set

Not set, Lisboa, Not set

Not set, Porto, Not set

Not set, Santarém, Not set

Not set, Aibonito, Not set

Not set, Rio Piedras, Not set

Not set, Jeddah, Not set

Not set, Riyadh, Not set

Not set, Belgrade, Not set

Not set, Bratislava, Not set

Not set, A Coruña, Not set

Not set, Barcelona, Not set

Not set, Córdoba, Not set

Not set, Elche, Not set

Not set, Girona, Not set

Not set, Granada, Not set

Not set, L'Hospitalet De Llobregat, Not set

Not set, Madrid, Not set

Not set, Málaga, Not set

Not set, Palma De Mallorca, Not set

Not set, Salamanca, Not set

Not set, Santa Cruz De Tenerife, Not set

Not set, Santiago De Compostela, Not set

Not set, Toledo, Not set

Not set, Valencia, Not set

Not set, Valladolid, Not set

Not set, Vitoria-Gasteiz, Not set

Not set, Skövde, Not set

Not set, Basel, Not set

Not set, Bern, Not set

Not set, Fribourg, Not set

Not set, Geneve, Not set

Not set, Lausanne, Not set

Not set, Lugano, Not set

Not set, Morges, Not set

Not set, Zürich, Not set

Not set, Taichung, Not set

Not set, Barnstaple, Not set

Not set, Birmingham, Not set

Not set, Blackpool, Not set

Not set, Bristol, Not set

Not set, Chelmsford, Not set

Not set, Glasgow, Not set

Not set, Harrow, Not set

Not set, Leeds, Not set

Not set, Leicester, Not set

Not set, Liverpool, Not set

Not set, London, Not set

Not set, Manchester, Not set

Not set, Middlesbrough, Not set

Not set, Newcastle Upon Tyne, Not set

Not set, Northampton, Not set

Not set, Sheffield, Not set

Not set, Southampton, Not set

Conditions: Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders, Digestive Disorders, Intracranial Aneurysm, Mechanical Circulatory Support, Respiratory Therapy, Aortic, Peripheral Vascular and Venous Disorders, Minimally Invasive Surgical Procedures, Diagnostic Techniques and Procedures, Surgical Procedures, Operative, Renal Insufficiency, Neurovascular, Coronary Artery Disease, Ear, Nose and Throat Disorder

Learn More ›

Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease

NCT06327984

Recruiting

There is a lack of understanding of how Coronary Artery Disease (CAD) - meaning the blocking or furring up of the arteries of the heart - starts and progresses in women. In both men and women, CAD is the most common cause of heart attacks, which occur when the blood supply in the heart is interrupted (these are also known medically as 'acute coronary syndromes'). Before the menopause women appear to be protected from CAD; however, after the menopause that protection is lost. Also, those women who do suffer a heart attack have twice the risk of further heart attacks compared to men despite having the same treatment that works well in men. Biological differences between men and women are probably playing an important role in the way CAD develops. However, due to a lack of research there is currently little understanding of how the female body works in this area. Inflammation is the body's natural response to injury or infection. Importantly it is also involved in the development of CAD. Hormones such as oestrogen and testosterone are also likely to be contributory factors. The investigators think the differences between the way these hormones and inflammation play a part in CAD in both men and women are important, but the role they play is not yet fully understood. In this study the investigators wish to measure the 'markers' of inflammation in the blood of patients attending Barts Heart Centre with chest pain. The investigators will also conduct questionnaires with these patients, to understand their hormone status and how parts of their medical history may be a contributory factor. For patients who have previously attended Barts Heart Centre will will contact them to conduct the questionnaire over the telephone only. The investigators will combine this data with the data that is routinely collected during hospital admission. In this way the investigators hope to understand whether inflammation together with hormone status plays an important role in CAD. Our hope is that through this research the investigators will address an under researched area and find new ways of treating women and men with coronary artery disease. Read Less

Gender:

ALL

Ages:

16 years and above

Trial Updated:

07/23/2025

Locations: Barts Health NHS Trust, London, Not set

Conditions: Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome, Atherosclerosis, Inflammation

Learn More ›

A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients

NCT04604782

Recruiting

This is a multi-centre, open-label, single-dose safety, tolerability and PK-pharmacodynamics (PD) study of the vasodilator regadenoson in 3 paediatric age groups for whom a pharmacologic stress perfusion CMR test is clinically indicated; adolescents aged 12 to \<18 years (Cohort A), children aged 2 to \<12 years (Cohort B), and infants aged 1 to \<24 months and who weigh at least 3 kg (Cohort C). Regadenoson will be used as the pharmacologic stress agent in this study with MPI serving as both su... Read More

Gender:

ALL

Ages:

Between 4 weeks and 18 years

Trial Updated:

07/08/2025

Locations: Paris Public Hospitals System; Necker Hospital for Sick Children, Paris, Not set +4 locations

Conditions: Myocardial Ischemia, Coronary Artery Disease

Learn More ›

CMR Versus CT in Coronary Artery Disease

NCT04761991

Recruiting

CONCORD is a prospective observational study evaluating the diagnostic accuracy of cardiovascular magnetic resonance (CMR) and computed tomography with fractional flow reserve (CT-FFR) in patients with suspected coronary artery disease, using invasive fractional flow reserve (FFR) as the reference standard.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/26/2025

Locations: Glenfield Hospital, Leicester, Leics

Conditions: Coronary Artery Disease

Learn More ›

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

NCT05701358

Recruiting

COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/16/2025

Locations: UCLA, Los Angeles, California +112 locations

UCLA, Los Angeles, California

University of California, San Francisco, San Francisco, California

Cardiovascular Research Institute of Kansas, Wichita, Kansas

The Johns Hopkins University School of Medicine, Baltimore, Maryland

University of Michigan, Ann Arbor, Michigan

Metropolitan Cardiology Consultants / Metropolitan Heart and Vascular Institute (MCC/MHVI), Coon Rapids, Minnesota

RWJ Barnabas Health, Jersey City, New Jersey

Montefiore Medical Center, Bronx, New York

Bassett Medical Center, Cooperstown, New York

VA New York Harbor HealthCare System, New York, New York

NYU Grossman School of Medicine, New York, New York

Cleveland Clinic, Cleveland, Ohio

University of Virginia Medical Center, Charlottesville, Virginia

Westmead Hospital, Westmead, New South Wales

Klinik Floridsdorf, Vienna, Not set

McGill University Health Centre (MUHC), Montréal, Quebec

William Osler Health System, Brampton, Not set

University of Alberta Hospital, Mazankowski Heart, Edmonton, Not set

Hamilton Health Sciences, Hamilton, Not set

Kingston Health Sciences Centre, Kingston, Not set

St. Mary's General Hospital, Kitchener, Not set

London Health Sciences Centre, London, Not set

Centre Hospitalier de l'Universite de Montreal, Montréal, Not set

Hopital du Sacre-Coeur de Montreal, Montréal, Not set

Southlake Regional Health Centre, Newmarket, Not set

Nova Scotia Health, Nova Scotia, Not set

University of Ottawa Heart Institute, Ottawa, Not set

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Not set

Regina General Hospital, Regina, Not set

Royal University Hospital, Saskatoon, Not set

Niagara Health, St. Catharines, Not set

Newfoundland and Labrador Health Services, St. John's, Not set

Thunder Bay Regional Health Sciences Centre, Thunder Bay, Not set

St. Michael's Hospital (Unity Health Toronto), Toronto, Not set

Sunnybrook Health Sciences Centre, Toronto, Not set

Ciusss McQ - Chaur, Trois-Rivières, Not set

St Paul's Hospital, Vancouver, Not set

Vancouver General Hospital, Vancouver, Not set

St. Boniface Hospital, Winnipeg, Not set

St. Anne's University Hospital, Brno, Not set

Aalborg University Hospital, Aalborg, Not set

Aarhus University Hospital, Aarhus, Not set

Rigshospitalet - Copenhagen University Hospital, Copenhagen, Not set

Helsinki University Hospital, Helsinki, Not set

TAYS Sydankeskus Oy, Tampere, Not set

Turku University Hospital, Turku, Not set

St. Vinzenz-Hospital, Cologne, Not set

Helios Amper-Klinikum, Dachau, Not set

Universitatsklinikum Frankfurt, Frankfurt, Not set

Marienkrankenhaus, Hamburg, Not set

Schoen Klink Hamburg, Hamburg, Not set

University Heart & Vascular Center Hamburg, Hamburg, Not set

WKK Heide, Heide, Not set

Gottsegen National Cardiovascular Center, Budapest, Not set

University of Szeged, Szeged, Not set

Lisie Hospital, Ernakulam, Kerala

Meditrina Hospital, Kollam, Kerala

Caritas Hospital Trust, Kottayam, Kerala

Apollo Rajshree Hospitals, Indore, Madhya Pradesh

Rukmani Birla Hospital, Jaipur, Rajasthan

Apollo Hospital, Chennai, Tamil Nadu

The Madras Medical Mission, Chennai, Tamil Nadu

Meenakshi Mission Hospital and Research Center, Madurai, Tamil Nadu

Medicover Hospitals, Hyderabad, Not set

Krishna Institute of Medical Sciences, Secunderabad, Not set

Azienda USL Toscana Sud Est, Arezzo, Not set

UOC Cardiologia - Ospedale Maggiore, Bologna, Not set

Azienda Ospedaliero - Universitaria di Ferrara, Ferrara, Not set

Misericordia Hospital, Grosseto, Not set

Azienda USL-IRCCS di Reggio Emilia, Reggio, Reggio Emilia, Not set

Sant Andrea Hospital - Sapienza University, Rome, Not set

Sorlandet Hospital Arendal, Kristiansand, Arendal

Oslo University Hospital Ulleval, Oslo, Not set

Stavanger University Hospital, Stavanger, Not set

University Hospital Tromso, Tromso, Not set

Provincial Specialized Hospital, Legnica, Dolnoslaskie

Miedziowym Centrum Zdrowia S.A. w Lubinie, Lubin, Dolnoslaskie

Medical University of Warsaw, Warsaw, Mazowieckie

Institute for Cardiovascular Diseases Dedinje, Belgrade, Not set

University Clinical Center of Serbia, Belgrade, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital Ramon y Cajal, Madrid, Not set

Hospital Universitario de La Princesa, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Virgen del Rocio, Seville, Not set

Hospital Universitari i Politecnic La Fe, Valencia, Not set

Hospital Clinico Universitario de Valladolid, Valladolid, Not set

Karolinska University Hospital, Huddinge, Not set

Lanssjukhuset RYHOV, Jonkoping,, Not set

Karlstad Central Hospital, Karlstad, Not set

Skane University Hospital, Lund, Not set

Danderyd Hospital, Stockholm, Not set

Umeå University Hospital, Umeå, Not set

Uppsala University Hospital, Uppsala, Not set

East Kent Hospitals University NHS Foundation Trust, Ashford, Not set

Blackpool Teaching Hospitals, Blackpool, Not set

Ninewells Hospital, Dundee, Not set

Harefield Hospital, Harefield, Not set

Kettering General Hospital, Kettering, Not set

University Hospitals of Leicester, Leicester, Not set

Liverpool Heart and Chest Hospital, Liverpool, Not set

Barts Health NHS Trust, London, Not set

Imperial College Healthcare NHS Trust, London, Not set

Royal Free London NHS Foundation Trust, London, Not set

Manchester University NHS Foundation Trust, Manchester, Not set

The James Cook University Hospital, Middlesbrough, Not set

Freeman Hospital, Newcastle upon Tyne, Not set

Royal Berkshire Foundation NHS Trust, Reading, Not set

Sheffield Teaching Hospitals, Sheffield, Not set

East and North Hertfordshire NHS Trust, Stevenage, Not set

Royal Cornwall Hospitals NHS Trust, Truro, Not set

The Royal Wolverhampton NHS Trust, Wolverhampton, Not set

Worcestershire Acute Hospitals NHS Trust, Worcester, Not set

Conditions: Acute Myocardial Infarction, Coronary Artery Disease

Learn More ›

High Frame Rate Ultrasound in Heart Disease Assessment

NCT03850015

Recruiting

The study will compare standard ultrasound images to high frame rate ultrasound images in patients with heart disease or with a low risk of heart disease to see if a higher frame rate of ultrasound adds to the information obtained from standard ultrasound.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/21/2025

Locations: London North West University Healthcare NHS Trust, Harrow, Middx

Conditions: Coronary Artery Disease

Learn More ›

SECURE Trial: Stress Echocardiography With Carotid Ultrasound vs Routine CT Coronary Angiography in Chronic Coronary Syndrome for Endpoints

NCT06185530

Recruiting

Diseases of the heart and circulation are known as cardiovascular diseases, and they cause over 160,000 deaths each year. Coronary heart disease (CHD) is the most common cardiovascular disease. This is due to a build-up of fatty material, known as atherosclerosis, in the blood vessels supplying blood to the heart muscle. This can cause chest pain or if blocked, can cause a heart attack. Two of the main non-invasive tests to look for coronary heart disease are Computed Tomography Coronary Angio... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/19/2025

Locations: London North West University Healthcare NHS Trust, Harrow, Middx

Conditions: Chronic Coronary Syndrome, Coronary Disease, Coronary Artery Disease

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

NCT04124120

Recruiting

The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grfating (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grfating (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocardial infarction, repeat revascularization, and hospital readmission for acute coronary syndrome or heart failure) in a cohort of 2,000 women randomized 1:1 to MAG or SAG (690 from the parent ROMA trial + 1,310 from ROMA:Women). Differences by important clinical and surgical subgroups (patients younger or older than 70 years, diabetics, racial and ethnic minorities, on vs off pump CABG, type of arterial grafts used) will also be evaluated. The women enrolled in the ongoing ROMA trial (anticipated to be approximately 690) will be included in ROMA:Women, increasing efficiency and reducing enrollment time. Hypothesis 1.0. MAG will reduce the incidence of major adverse cardiac and cerebrovascular events. Hypothesis 1.1. The improvement with MAG will be consistent across key subgroups. Aim 2: Determine the impact of MAG vs SAG on generic and disease-specific QOL, physical and mental health symptoms in women undergoing CABG. The investigators will compare generic (SF-12, EQ-5D) and disease-specific (Seattle Angina Questionnaire) QOL and physical and mental health symptoms (PROMIS-29) in a sub-cohort of 500 women randomized 1:1 to MAG or SAG (including those enrolled in ROMA:QOL). Differences by important subgroups (as defined above) will also be evaluated. Hypothesis 2.0. MAG will improve generic and disease-specific QOL compared to SAG. Hypothesis 2.1. MAG will improve physical and mental health symptoms compared to SAG. Hypothesis 2.2. The improvement with MAG will be consistent across key subgroups. Read Less

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

04/04/2025

Locations: Cedars-Sinai Medical Center, Los Angeles, California +140 locations

Cedars-Sinai Medical Center, Los Angeles, California

Pomona Valley Hospital Medical Center, Pomona, California

University of California, San Francisco, San Francisco, California

University of Colorado, Aurora, Colorado

Hartford Hospital, Hartford, Connecticut

Yale University Hospital, New Haven, Connecticut

Emory University, Atlanta, Georgia

University of Chicago, Chicago, Illinois

University of Iowa, Iowa City, Iowa

Johns Hopkins University, Baltimore, Maryland

Baystate Health, Springfield, Massachusetts

University of Massachusetts Chan Medical School, Worcester, Massachusetts

University of Michigan, Ann Arbor, Michigan

Corewell Health William Beaumont University Hospital, Royal Oak, Michigan

Washington University in St. Louis, Saint Louis, Missouri

Nebraska Heart Hospital, Lincoln, Nebraska

Methodist Physicians Health, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Englewood Health, Englewood, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

The Valley Hospital, Ridgewood, New Jersey

NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York

Weill Cornell Medicine, New York, New York

Columbia University Medical Center, New York, New York

Lenox Hill Hospital, New York, New York

New York Presbyterian Queens, Queens, New York

Duke University, Durham, North Carolina

East Carolina University, Greenville, North Carolina

Wake Forest University, Winston-Salem, North Carolina

Cleveland Clinic Foundation, Cleveland, Ohio

Ohio State University, Columbus, Ohio

Genesis Healthcare System, Zanesville, Ohio

University of Pennsylvania, Philadelphia, Pennsylvania

Allegheny General Hospital, Pittsburgh, Pennsylvania

Lankenau Medical Center, Wynnewood, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Baylor Scott & White Research Institute, Dallas, Texas

The University of Texas Medical Health Branch at Galveston, Galveston, Texas

Baylor College of Medicine, Houston, Texas

UT Health San Antonio, San Antonio, Texas

University of Utah, Salt Lake City, Utah

Victorian Heart Hospital, Clayton, Not set

The University of Melbourne, Melbourne, Not set

Medical University of Graz, Graz, Not set

Innsbruck Medical University, Innsbruck, Not set

Kepler University Hospital, Linz, Not set

Medical University of Vienna, Vienna, Not set

Krankenhaus Nord Vienna North Hospital, Vienna, Not set

Institute of Cardiology Porto Alegre, Porto Alegre, Not set

Heart Institute University of São Paulo, São Paulo, Not set

Instituto Dante Pazzanese de Cardiologia, Vila Mariana, Not set

St. Boniface General Hospital, Winnipeg, Manitoba

Horizon Health Network - Saint John Regional Hospital, Saint John, New Brunswick

NL Health Services, St. John's, Newfoundland and Labrador

Hamilton General Hospital, Hamilton, Ontario

London Health Sciences, London, Ontario

University of Ottawa Heart Institute, Ottawa, Ontario

Health Sciences North, Sudbury, Ontario

Sunnybrook Health Sciences, Toronto, Ontario

Toronto General Hospital, Toronto, Ontario

Montreal Heart Institute, Montréal, Quebec

University Hospital of Montreal, Montréal, Quebec

Royal Victoria Hospital, Montréal, Quebec

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Ste Foy, Quebec

Hopital Sacre-Coeur, Montréal, Not set

Fraser Clinical Trials, New Westminster, Not set

Fuwai Hospital China, Beijing, Beijing

Jilin Heart Hospital China, Changchun, Jilin

Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai

Teda Hospital Tianjin China, Tianjin, Tianjin

University Hospital Dubrava, Zagreb, Not set

University Hradec Králové, Hradec Králové, Not set

General University Hospital, Prague, Nové Město, Not set

Aalborg University Hospital, Aalborg, Not set

Rigshospitalet, Copenhagen, Not set

Universitäts-Herzzentrum Bad Krozingen Freiburg, Bad Krozingen, Baden-Wuerttemberg

HDZ NRW Bad Oeynhausen Germany, Bad Oeynhausen, Not set

Deutsches Herzzentrum der Charite, Berlin, Not set

Duisburg Heart Center, Duisburg, Not set

Dusseldorf University, Düsseldorf, Not set

University Hospital Erlangen, Erlangen, Not set

Essen University, Essen, Not set

Frankfurt University, Frankfurt, Not set

University Hospital of Giessen and Marburg, Gießen, Not set

University Medical Center of Göttingen, Göttingen, Not set

Jena University Hospital, Jena, Not set

Heart Center Herzzentrum, Leipzig, Leipzig, Not set

Robert-Bosch-Hospital Stuttgart Germany, Stuttgart, Not set

Krankenhaus der Barmherzigen Brüder Trier, Trier, Not set

G Kuppuswamy Naidu Memorial Hospital (GKNM), Coimbatore, Tamil Nadu

Star Hospitals - Hyderabad, India, Hyderabad, Telangana

Rambam Health Care Campus, Haifa, Not set

Anthea Hospital, Bari, Not set

Humanitas Gavazzeni of Bergamo, Bergamo, Not set

Fondazione Poliambulanza, Brescia, Not set

Maria Cecilia Hospital GVM, Cotignola, Not set

Careggi University Hospital, Florence, Not set

European Hospital, Roma, Not set

Universita' Cattolica del Sacro Cuore, Roma, Not set

Ospedale Le Molinette, Torino, Torino, Not set

Tokyo Medical and Dental University, Bunkyō-Ku, Tokyo

Saitama Medical University Japan, Saitama, Not set

Seoul National University Hospital, Seoul, Not set

Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seúl, Not set

Leiden University Medical Center, Leiden, South Holland

Erasmus Medical Center, Rotterdam, South Holland

Maastricht University Medical Centre, Maastricht, Not set

Acibadem-Sistina Hospital, Skopje, Not set

Medical University Gdansk, Gdańsk, Not set

Medical University of Silesia, Katowice, Not set

Zbigniew Religa Lower Silesian Heart Disease Centre, Zabrze, Not set

University Hospital Coimbra, Coimbra, Not set

Centro Hospitalar Lisboa Ocidental, Lisboa, Not set

Centro Hospitalar e Universitário Sao Joao, Porto, Not set

Centro Hospitalar e Universitário Sao João, Porto, Not set

National Research Medical Center of the Russian Academy of Sciences - Tomsk, Russia, Tomsk, Not set

Dedinje Cardiovascular Institute, Belgrade, Not set

National University of Singapore, Singapore, Not set

Hospital Universitario del Vinalopo, Elx, Alicante

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital Clinico de San Carlos, Madrid, Not set

NavarraBiomed, Pamplona, Not set

Sahlgrenska University Hospital, Gothenburg, Not set

Karonlinska University Hospital, Stockholm, Not set

National Taiwan University Hospital, Zhongzheng, Taipei

Blackpool Teaching Hospitals NHS Trust, Blackpool, Lancashire

Oxford University Hospitals NHS Trust, Multiple Locations, Oxford

University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, Staffordshire

Royal Papworth NHS Foundation Trust, Cambridge, Not set

NHS Golden Jubilee, Clydebank, Not set

The Royal Infirmary of Edinburgh, Edinburgh, Not set

Hull University Hospitals, Hull, Not set

University Hospitals of Leicester, Leicester, Not set

Liverpool Heart and Chest Hospital Foundation Trust, Liverpool, Not set

Guy's and St Thomas' NHS Foundation Trust, London, Not set

Imperial College Healthcare NHS Trust, London, Not set

St George's University Hospitals, London, Not set

Manchester University NHS Trust, Manchester, Not set

South Tees Hospitals NHS Trust, Middlesbrough, Not set

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, Not set

Royal Wolverhampton NHS Trust, Wolverhampton, Not set

Conditions: Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting

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Decision Support Tool for Revascularisation Options in Coronary Artery Disease

NCT06567626

Recruiting

Together with patients and healthcare professionals, we want to design a Decision Support Tool (DST) that will help people with coronary artery disease to understand and choose treatments that best reflect their preferences and values. Coronary artery disease (CAD) is a leading cause of death. Blood vessels supplying oxygen to the heart muscle become narrowed by a gradual build-up of fatty material. This can result in heart attacks, heart failure, and sudden death. One way to treat the blockage is by inserting an inner sleeve called a "stent" into the blood vessel and clearing the blockage by forcing it into the artery wall. Another method involves diverting the blood supply around the blockage using a vessel harvested from another body site; this is called "bypass surgery". The best treatment, either stents or surgery, is different for everyone. A Decision Support Tool (DST) will provide key information on the pros and cons of stents or surgery and how these match an individual's preferences and values. People are then empowered to make shared decisions about treatment with their doctors. Personalising treatment decisions in this way can reduce inequalities in care and improve shared decision making. Our proposed research will develop a DST in the form of a webpage with alternative print material for those at risk of digital poverty. The DST will be developed in multiple languages to improve accessibility. There are two parts to the study: the first part will use the experience of patients, who have already had stent or surgery, and healthcare professionals to design and refine a DST prototype; this will be done through workshops, focus groups, and cognitive interviews. The second part will test whether it is possible to use the DST by people with CAD waiting for a procedure; this will be done through questionnaires and interviews. The result of this study can then subsequently inform an assessment of the refined DST on a national level, with the hopes of enabling more effective shared decision making. Read Less

Gender:

ALL

Ages:

All

Trial Updated:

03/31/2025

Locations: University of Leicester, Leicester, Not set +1 locations

Conditions: Coronary Artery Disease

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Development of Novel Physiological CMR Methods in Health and Disease

NCT03854071

Recruiting

Physiological cardiovascular stress test plays a crucial role in the assessment of patients with suspected heart disease. There are several methods of cardiac physiological stress tests and each of them offer varied insight into cardiac physiological adaptation: passive leg raise, intra-venous fluid challenge, pharmacological stressors and physical exercise stress test. Echocardiography, which is the mainstay for the non-invasive rest/stress assessment of the left ventricular (LV) haemodynamics... Read More

Gender:

ALL

Ages:

Between 20 years and 80 years

Trial Updated:

12/09/2024

Locations: Sheffield Teaching Hospitals NHS FT, Sheffield, England

Conditions: Heart Failure, Pulmonary Hypertension, Myocardial Infarction, Coronary Artery Disease

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Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology

NCT06325020

Recruiting

The ORACLE study is an observational cohort study designed to explore the feasibility of providing an assessment of chest pain for patients with suspected angina within one working day of referral to specialist services. The primary objective is to determine the feasibility of delivering an objective assessment of risk for participants who have been referred by their primary care provider to the rapid access chest pain clinic with possible angina in a community setting using point of care and p... Read More

Gender:

ALL

Ages:

30 years and above

Trial Updated:

11/27/2024

Locations: NHS Lothian, Edinburgh, Not set

Conditions: Angina, Stable, Coronary Artery Disease

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