There are currently 9 active clinical trials seeking participants for Diabetes Mellitus research studies. The states with the highest number of trials for Diabetes Mellitus participants are .
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
NCT05198674
Recruiting
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be collected from eligible subjects previously treated in the SPYRAL PIVOTAL-SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED studies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama +99 locations
Conditions: Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
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Is Community Based Monitoring of Diabetic Maculopathy and Pre-proliferative Diabetic Retinopathy Safe?
NCT06955611
Recruiting
To assess a pathway using opticians based in their practices and a 'virtual' review by a consultant ophthalmologist, based in the hospital to assess suspected diabetic maculopathy. We want to know if this pathway works, is it acceptable to people with diabetes and what the changes might mean in terms of the outcomes for patients and NHS resources and cost? Screening by Diabetic Eye Service Wales currently involves taking and as-sessing 2-D (dimensional) digital photographs of the back of the ey... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: Hwyel Dda University Health Board, Haverfordwest, Not set
Conditions: Diabetes Mellitus, Diabetic Retinopathy, Diabetic Maculopathy
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Diabetes in Primary Care - Improving Classification
NCT06711718
Recruiting
This study aims to evaluate the clinical utility and acceptability to patients and practitioners of running diabetes classification algorithms on primary care data to help improve diagnosis of diabetes subtypes in adults diagnosed with diabetes under the age of 50. The outputs from this research will help provide initial data on how best to use these algorithms in primary care and the optimal design of a decision support tool that could be taken forward to a full trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Tamar Valley Health, Plymouth, Cornwall +8 locations
Conditions: Diabetes Mellitus
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EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
NCT03987633
Recruiting
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the extent and basis of treatment failure in different patient populations. The vast majority of drug registration clinical trials have under-representation of ethnic minority populations. In addition, the wider Caucasian populations have reasonably different clinical characte... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
03/05/2025
Locations: Future Genetics, The Science Centre, Wolverhampton Science Park, Wolverhampton, West Midlands
Conditions: Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure, Hypertension, Peripheral Arterial Disease, Stroke, Ischemic, Asthma, Chronic Obstructive Pulmonary Disease, Obesity, Cancer, Chronic Kidney Diseases, Diabetes Mellitus, Dementia, Depression, Epilepsy, Mental Health Disorder, Rheumatoid Arthritis, Blood Pressure, Breast Cancer Risk, Prostate Cancer, Lung Cancers
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Continuous Glucose Monitoring in People With Diabetes on Dialysis
NCT06657508
Recruiting
Continuous glucose monitoring is a sensor, which monitors glucose levels continuously throughout the day. In people with diabetes, especially those treated with insulin, this sensor helps guide the amount of treatment (such as insulin) required to maintain glucose within target. In dialysis, the glucose levels and insulin needs can change a lot because of the kidney failure and dialysis treatments. The goal of this observational study is to describe the changes in glucose during and in between... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: University Hospitals of Derby and Burton, Derby, Not set
Conditions: Diabetes Mellitus, End-Stage Renal Disease
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Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)
NCT06478121
Recruiting
This observational 'recruit by genotype' study aims to provide insights into the cellular and molecular pathways underlying beta cell disorders and their physiological consequences. Eligible individuals are those with and without a pathogenic genetic variant, acting as case and control, respectively. Using a "recruit by genotype" approach, the researchers will perform detailed and specific analysis according to the individual's genetic variant. The study's main aims are to : 1) identify and des... Read More
Gender:
ALL
Ages:
Between 6 years and 99 years
Trial Updated:
01/07/2025
Locations: Royal Devon University Healthcare NHS Foundation Trust, Exeter, Devon
Conditions: Diabetes Mellitus, Monogenic Diabetes, Hyperinsulinism
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Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes
NCT00948116
Recruiting
Patients living with diabetes mellitus have double the risk of kidney failure compared to patients without diabetes following use of dye in many x-rays and procedures to diagnose and treat narrowing of the arteries (blood vessels) in the heart that can lead to angina or a heart attack. Heart disease is the commonest cause of death in patients with diabetes. People with diabetes are more likely to need these tests/treatments. By identifying those at greater risk of kidney complications we may be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: The London Chest Hospital, London, Not set
Conditions: Diabetes Mellitus, Renal Impairment
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Paraoxonase and HDL Qualities in Glycaemia and Inflammation
NCT02169518
Recruiting
The incidence of coronary heart disease (CHD) is significant in the super-obese and diabetics. Inflammation is believed to play an important part in the development of CHD, and the large collection of abdominal fat in the obese person is a vast source of inflammation. Diabetics have abnormal glucose and cholesterol metabolism which ultimately compromise their bodies' circulatory system and nerve function. Cholesterol plays a vital role in CHD. Low-density lipoprotein (LDL) particles carry chol... Read More
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
04/11/2023
Locations: Central Manchester University Hospitals NHS Foundatioon Trust, Manchester, Lancashire
Conditions: Diabetes Mellitus, Bariatric Surgery Candidate
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Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
NCT05705869
Recruiting
This is a prospective, multicentre, unblinded, randomised, controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients with diabetes.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
01/27/2023
Locations: Glasgow Royal Infirmary, Glasgow, Scotland +1 locations
Conditions: Heart Failure, Diabetes Mellitus, Type 1 Diabetes, Type 2 Diabetes, Cardiovascular Diseases
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