There are currently 15 active clinical trials seeking participants for Diabetes Mellitus, Type 2 research studies. The states with the highest number of trials for Diabetes Mellitus, Type 2 participants are .
A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
NCT07064473
Recruiting
This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empagliflozin, helps reduce cardiovascular risk in people with these conditions. The study will compare this combination to a placebo version of vicadrostat with empagliflozin. Participants are put into 2 gro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +1056 locations
Conditions: Diabetes Mellitus, Type 2, Hypertension, Cardiovascular Diseases
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A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy
NCT06797869
Recruiting
This study will look at the effects of CagriSema in people with both type 2 diabetes and painful diabetic peripheral neuropathy, compared to placebo. Participants will either get an active medicine or a "dummy" medicine (placebo). Which treatment participants get is decided by chance. In this study the active, investigational medicine is called CagriSema. Doctors cannot yet prescribe CagriSema. For each participant, the study will last for about 10 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: eStudySite, La Mesa, California +49 locations
Conditions: Diabetes Mellitus, Type 2, Diabetic Peripheral Neuropathy
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The Poor Responders Study
NCT05404061
Recruiting
Obesity and type 2 diabetes are major causes of illness and premature death worldwide and their incidence is increasing rapidly. Bariatric surgery is considered as the "gold-standard" surgical treatment for both conditions. However, not all patients do equally well after surgery and indeed the weight loss experienced by patients undergoing bariatric surgery can vary. As such when patients are seen after bariatric surgery in clinic they fall in one of the following two categories: 1. Good respo... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/06/2025
Locations: Imperial College London, London, Not set
Conditions: Bariatric Surgery Candidate, Obesity, Morbid, Diabetes Mellitus, Type 2
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An Analysis to Assess Non-adherence in People With Type 2 Diabetes
NCT05256875
Recruiting
Non-adherence is defined as: "the extent to which a person's behaviour - taking medication, following a diet, and/or executing lifestyle changes, corresponds with agreed recommendations from a health care provider". Non-adherence in chronic cardiometabolic diseases including diabetes is very common and is often the primary reason for treatment failure. This leads to significant excess costs to the health economy through avoidable investigations, treatment escalations, hospital admissions, and di... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: The Banks Surgery, Loughborough, Not set +1 locations
Conditions: Diabetes Mellitus, Type 2, Hypertension, Medication Adherence
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A Study Looking to Improve Sleep and Reduce Sedentary Behaviour in Those Living With Type 2 Diabetes Mellitus
NCT06471634
Recruiting
The goal of this clinical feasibility trial is to learn whether the investigators can improve sleep and reduce sedentary behaviour in people living with Type 2 diabetes mellitus with sleep problems. The main questions it aims to answer are: • question 1, can objectively measured sleep and sedentary behaviour be improved in the participants and • question 2, what effect will this have on a number of physical and physiological markers. Participants in the intervention group will be asked to keep s... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/24/2025
Locations: Diabetes Research Centre University Hospitals Leicester, Leicester, Leicestershire
Conditions: Diabetes Mellitus, Type 2, Insomnia, Sedentary Behavior
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Driving with Neuropathy
NCT06739135
Recruiting
This study is a proof-of-concept randomised controlled trial (RCT). The goal of the study is to investigate the effectiveness of a feedback intervention to improve use of the accelerator pedal in patients driving with diabetes and peripheral neuropathy (DPN). The main (primary) question it aims to answer is: What is the effect of a visual feedback intervention (over 6 sessions a month apart), compared to no feedback, on accelerator pedal use by drivers with diabetic peripheral neuropathy? Our... Read More
Gender:
ALL
Ages:
Between 25 years and 69 years
Trial Updated:
12/16/2024
Locations: Manchester Metropolitan University, Manchester, Not set
Conditions: Diabetic Polyneuropathy, Diabetes Mellitus, Type 2
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A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
NCT05887271
Recruiting
Heart failure with preserved ejection fraction (HFpEF) is a common and serious complication of obesity and type 2 diabetes (T2D). HFpEF occurs when the heart muscle unable to relax efficiently to pump the blood around the body. This leads to fluid build-up, breathlessness and inability to tolerate physical exertion. People who develop HFpEF do less well because treatment options are limited. Pilot data in patients with obesity and diabetes and a small number of patients with HFpEF have shown imp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/28/2024
Locations: University of Leicester, Glenfield Hospital, Groby Road, Leicester, Leicestershire +2 locations
Conditions: Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Obesity Adult Onset
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A Study of Cardiovascular Events iN Diabetes Plus
NCT05441267
Recruiting
ASCEND PLUS is testing whether, for people with type 2 diabetes who have not previously had a heart attack or stroke, regularly taking a tablet called semaglutide can safely help to reduce heart attacks, strokes, mini-strokes, the need for any procedures to unblock or bypass an artery to their heart, and the chance of dying because of vascular problems.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/07/2024
Locations: Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford, Not set
Conditions: Diabetes Mellitus, Type 2
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A UK Registry for Metabolic and Bariatric Endoscopic Interventions
NCT06305208
Recruiting
In the UK alone, obesity is a major health problem with more than one quarter of adults estimated to be obese. Obesity promotes the development of many serious diseases including diabetes, heart disease, kidney disease, and increased risk of some cancers. Patients living with obesity also suffer from significant symptoms that impact their life including shortness of breath, back pain, poor mobility, and poor mental health. Traditional methods to help lose weight include low calorie diets and inc... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/13/2024
Locations: Cleveland Clinic London, London, Not set
Conditions: Obesity, Diabetes Mellitus, Type 2
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Role of Fasted Exercise on Improving Cardiometabolic Health
NCT05742373
Recruiting
The aim of this randomised control trial is to investigate the role of fasted exercise on cardiometabolic health. Participants will be assigned to one of three conditions, fasted exercise, fed exercise and control (no exercise). Participants in the exercise groups will complete four weeks of moderate intensity cycling exercise, three times per week, either in the fasted or fed state according to their group assignment. Experimental trials involving anthropometric and cardiometabolic disease risk... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
03/06/2024
Locations: Manchester Metropolitan University, Manchester, Greater Manchester
Conditions: Cardiovascular Diseases, Diabetes Mellitus, Type 2, Obesity
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Chronotype of Patients With Diabetes and Effect on Glycaemic Control
NCT02973412
Recruiting
The aim of this study is to explore the associations between chronotype and glycaemic control, cardiometabolic health and other lifestyle factors.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/14/2024
Locations: Leicester Diabetes Centre, Leicester General Hospital, Leicester, Not set
Conditions: Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
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Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus
NCT03132129
Recruiting
Background: Heart failure is a major cause of morbidity and mortality in diabetes mellitus, but its pathophysiology is poorly understood. Aim: To determine the prevalence and determinants of subclinical cardiovascular dysfunction in adults with type 2 diabetes (T2D). Plan: 518 asymptomatic adults (aged 18-75 years) with T2D will undergo comprehensive evaluation of cardiac structure and function using cardiac MRI (CMR) and spectroscopy, echocardiography, CT coronary calcium scoring, exercise to... Read More
Gender:
ALL
Ages:
Between 50 years and 75 years
Trial Updated:
01/03/2024
Locations: University of Leicester, Leicester, Not set
Conditions: Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
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