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Carboplatin Treatment Options in United Kingdom
A collection of 302 research studies where Carboplatin is the interventional treatment. These studies are located in the United Kingdom . Carboplatin is used for conditions such as Non-Small Cell Lung Cancer, Ovarian Cancer and Lung Cancer.
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Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
Recruiting
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC).
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Southern Cancer Center Pc, Daphne, Alabama +246 locations
Southern Cancer Center Pc, Daphne, Alabama
Ironwood Cancer and Research Centers, Chandler, Arizona
Arizona Oncology Associates, Pc - Nahoa, Prescott Valley, Arizona
Hoag Memorial Hospital Prebyterian, Newport Beach, California
Compassionate Cancer Care Medical Group, Riverside, California
Sansum Clinic, Santa Barbara, California
Ronald Reagan UCLA Medical Center, Santa Monica, California
UCHealth Memorial Hospital, Colorado Springs, Colorado
Florida Cancer Specialists - South, Fort Myers, Florida
Cancer Specialist of North Florida, Jacksonville, Florida
Cancer Care Centers of Brevard, Inc., Palm Bay, Florida
Woodlands Medical Specialists, Pa, Pensacola, Florida
Florida Cancer Specialists-North, Saint Petersburg, Florida
Emory University - Winship Cancer Institute Wci, Atlanta, Georgia
Illinois Cancer Specialists, Niles, Illinois
American Oncology Partners of Maryland, Bethesda, Maryland
Maryland Oncology Heamtology P.A., Columbia, Maryland
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana Farber Cancer Institute; Inv Drg Svc Pharm, Boston, Massachusetts
Dana Farber Cancer Institute At St. Elizabeth'S Medical Center, Brighton, Massachusetts
Dana Farber Brigham Cancer Center, Foxboro, Massachusetts
Dana Farber At Milford Regional Cancer Center, Milford, Massachusetts
Dana Farber/Bwcc in Affiliation With South Shore Hospital, South Weymouth, Massachusetts
Astera Cancer Care, East Brunswick, New Jersey
Regional Cancer Care Associates LLC, Hackensack, New Jersey
North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists - Bronx, Bronx, New York
North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists- New Hyde Park, New Hyde Park, New York
North Shore Hematology Oncology Associates, Patchogue, New York
North Shore Hematology Oncology Associates DBA NY Cancer and Blood Specialists, Port Jefferson Station, New York
Texas Oncology, P.A., McAllen, Texas
Ut Health San Antonio, San Antonio, Texas
Texas Oncology, P.A., Sugar Land, Texas
Texas Oncology-Tyler, Tyler, Texas
Utah Cancer Specialists IHO Corp, Salt Lake City, Utah
Providence Regional Cancer System, Lacey, Washington
VA Puget Sound Health Care System, Seattle, Washington
Instituto Alexander Fleming, Ciudad Autonoma de Buenos Aires, Not set
Fundacion CENIT para la investigacion en Neurociencias, Ciudad Autonoma de Buenos Aire, Not set
Hospital de La Comunidad, Mar del Plata, Not set
Centro de Investigacion Pergamino Sa, Pergamino, Not set
Instituto de Oncologia de Rosario, Rosario, Not set
Sanatorio Parque, Rosario, Not set
Centro Polivalente de Asistencia E Investigacion Clinica Cer San Juan, San Juan, Not set
Centro de Investigaciones Clinicas. Clinica Viedma S.A., Viedma, Not set
CRSA/ St Andrews Hospital, Adelaide, Not set
Flinders Medical Centre (Fmc), Bedford Park, Not set
PSEHOG (Peninsula and South Eastern Haematology and Oncology Group), Frankston, Not set
St George Public Hospital, Kogarah, Not set
Southern Medical Day Care Centre, Wollongong, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Landeskrankenhaus Feldkirch, Feldkirch, Not set
Klinikum Klagenfurt Pulmologie, Klagenfurt, Not set
Karl Landsteiner Institut Fã¼R Lungenforschung Und Pneumologische Onkologie C/O Klinik Floridsdorf, Vienna, Not set
Az Maria Middelares - Campus Maria Middelares, Gent, Not set
Centre hospitalier Jolimont-Lobbes, Haine Saint-Paul, Not set
Jessa Hospital, Hasselt, Not set
Cliniques Saint Pierre Ottignies (CSPO), Ottignies, Not set
Az Nikolaas, Sint-Niklaas, Not set
Personal Oncologia de Precisao - Cenantron, Belo Horizonte, Not set
Fundaco Universidade de Caxias Do Sul- Instituto de Pesquisas Em Saude Ips-Ucs, Caxias do Sul, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, Not set
Clínica de Neoplasias Litoral Ltda, ItajaĂ-, Not set
Clnica Lacks, Pelotas, Not set
Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Instituto Nacional de Că'Ncer - Inca, Rio de Janeiro, Not set
Centro de Estudos E Pesquisa de Hematologia E Oncologia - Cepho, Santo Andre, Not set
Instituto de Ensino E Pesquisa Sao Lucas, Sao Paulo, Not set
Instituto Do Cancer Brasil - Unidade Taubate, Taubate, Not set
CHU de Quebec -Universite Laval Hopital de L'Enfant-Jesus, Quebec City, Not set
Centro de Estudios Clinicos Saga Spa, Santiago de Chile, Not set
ONCOVIDA, Santiago, Not set
Orlandi Oncologia, Santiago, Not set
Oncocentro Apys, Vina Del Mar, Not set
Centro de Investigaciones Clinicas Vina Del Mar, ViĂąa Del Mar, Not set
Peking University Cancer Hospital Beijing Cancer Hospital Beijing Institute For Cancer Research, Beijing Sheng, Not set
Peking University Peoples Hospital, Beijing, Not set
Cangzhou Peoples Hospital, Cangzhou, Not set
First Affiliated Hospital of Medical College of Jilin University, Changchun, Not set
Jilin Cancer Hospital, Changchun, Not set
Hunan Cancer Hospital, Changsha, Not set
University of Electronic Science Technology of China UESTC - Sichuan Cancer Hospital Institute SIC, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Fujian Medical University - Union Hospital Foochow Christian Union Hospital, Fuzhou, Not set
The First Affiliated Hospital Sun Yat-Sen University, Guangzhou, Not set
Affiliated Cancer Hospital and Insititute of Guangzhou Medical University, Guangzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Not set
The First Affiliated Hospital of College of Medicine Zhejiang University, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Inner Mongolia Medical University- the Affiliated Hospital, Hohhot, Not set
Jiamusi Cancer Hospital, Jiamusi, Not set
Linyi Cancer Hospital, Linyi, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Zhongda Hospital, Southeast University, Nanjing, Not set
Shanghai Chest Hospital, Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Liaoning Cancer Hospital & Institute, Shenyang, Not set
Union Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan, Not set
The First Affiliate Hospital of Xi'An Jiaotong University, Xi'an, Not set
Xiangyang Central Hospital, Xianyang, Not set
Henan Cancer Hospital, Zhengzhou, Not set
The First Affiliated Hosptial of Xinjiang Medical University, Ürümqi, Not set
FN Brno Klinika Nemoci Plicnich a TBC, Brno, Not set
Fakultni nemocnice Olomouc FNOL, Olomouc, Not set
Sainte-Catherine Institut du Cancer Avignon-Provence, Avignon, Not set
Hopital Jean Minjoz - CHU de Besancon, Besancon, Not set
Chu de Bordeaux - Hopital Saint Andre, Bordeaux, Not set
Centre Hospitalier Universitaire, CHU, de Poitiers, France, Not set
Hopital Lyon Sud, Lyon, Not set
Centre Leon Berard, Lyon, Not set
Aphm - Hopital Nord, Marseille Cedex 20, Not set
Institut Paoli Calmettes, Marseille, Not set
Chu de Montpellier, Montpellier Cedex 5, Not set
Chu de Nantes, Nantes, Not set
Hopital Prive Du Confluent, Nantes, Not set
Institut Curie, Paris Cedex 05, Not set
Tenon Hospital, Paris, Not set
CHU de Rennes - Hopital Pontchaillou, Rennes, Not set
Hôpital Foch, Suresnes, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Klinikum Chemnitz, Chemnitz, Not set
Universitaetsklinikum Essen, Essen, Not set
Klinikum Esslingen Gmbh, Esslingen, Not set
Universitaetsklinikum Freiburg, Freiburg, Not set
University Hospital Giessen, ZIM IV, Giessen, Not set
External pharmacy Fortuna Herstellung GmbH of main site Universitaetsmedizin Mannheim, Mannheim, Not set
University Hospital Mă Nster, Muenster, Not set
Ludwig-Maximilians University Hospital of Munich, Munich, Not set
Sotiria General Hospital of Chest Diseases, Athens, Not set
Metropolitan Hospital - Athens, Athens, Not set
University General Hospital of Heraklion, Heraklion, Not set
University Hospital of Ioannina Uhi, Ioannina, Not set
Metropolitan Hospital, Neo Faliro, Not set
Olympion Hospital, Patras, Not set
Euromedica General Clinic of Thessaloniki, Thessaloniki, Not set
St. Luke's Hospital, Thessaloniki, Not set
Bioclinic Thessaloniki (Galinos Clinic), Thessalonki, Not set
Tuen Mun Hospital, Hong Kong, Not set
Prince of Wales Hospital / The Chinese University of Hong Kong, Hong Kong, Not set
Queen Mary Hospital, Pok Fu Lam, Not set
National Koranyi Institute For Pulmonology, Budapest, Not set
Veszprem Megyei Tudogyogyintezet Farkasgyepu, Farkasgyepu, Not set
Bkmk Hospital, KecskemĂŠt, Not set
Fejer Megyei Szent Gyorgy Korhaz Pulmonologiai Osztaly, Szekesfehervar, Not set
Hetenyi G Korhaz, Onkologiai Kozpont, Szolnok, Not set
Reformatus Pulmonologiai Centrum, Torokbalint, Not set
Istituto Di Candiolo Irccs, Candiolo, Not set
Ospedale San Luca, Lucca, Not set
Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano, Not set
IFO Regina Elena, Rome, Not set
Ospedale S. Maria Della Misericordia, Udine, Not set
Asst Sette Laghi, Varese, Not set
Azienda Ospedaliera Universitaria Integrata Verona Ospedale Borgo Roma Crc - Centro Ricerche Clinich, Verona, Not set
NHO Shikoku Cancer Center, Ehime, Not set
Kurume University Hospital, Fukoka, Not set
Kyushu Cancer Center, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Not set
Teine Keijinkai Hospital, Hokkaido, Not set
Hyogo Medical University Hospital, Hyogo, Not set
Kanazawa University Hospital, Ishikawa, Not set
Kanagawa Cancer Center, Kanagawa, Not set
Kitasato University hospital, Kanagawa, Not set
Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc. Saiseikai Kumamoto Hospital, Kumamoto, Not set
University Hospital Kyoto Prefectual University of Medicine, Kyoto, Not set
Matsusaka Municipal Hospital, Mie, Not set
Sendai Kousei Hospital, Miyagi, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Osaka International Cancer Institute, Osaka, Not set
Osaka Toneyama Medical Center, Osaka, Not set
Kansai Medical University Hospital, Osaka, Not set
NHO Kinki-Chuo Chest Medical Center, Osaka, Not set
Dokkyo Medical University Hospital, Tochigi, Not set
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Not set
Juntendo University Hospital, Tokyo, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Toho University Omori Medical Center, Tokyo, Not set
Iwakuni Clinical Center, Yamaguchi, Not set
Yamaguchi-Ube Medical Center, Yamaguchi, Not set
Yamanashi Prefectural Central Hospital, Yamanashi, Not set
Chungbuk National University Hospital, Cheongjusi, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Samsung Medical Center, Gangnam-Gu, Not set
National Cancer Center, Goyang-si, Not set
Gyeongsang National University Hospital, Jinju-si Gyeongsangnam-do, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Asan Medical Center, Seoul, Not set
Yonsei University Health System - Severance Hospital, Seoul, Not set
The Catholic Univ. of Korea, Seoul St. Marys Hospital, Seoul, Not set
Cryptex Investigacion Clinica Sa de Cv, Cuauhtemoc, Not set
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Not set
Instituto Nacional de Cancerologia, Mexico City, Not set
Centro de Investigacion Clinica de Oaxaca CICLO, Oaxaca, Not set
Amphia Ziekenhuis, Breda, Not set
Leiden University Medical Center, Leiden, Not set
Jeroen Bosch Ziekenhuis Jbz, s-Hertogenbosch, Not set
II Klinika Chorob Pluc i Gruzlicy, Bialystok, Not set
Centrum Terapii Wspolczesnej, Lodz, Not set
Instytut Centrum Zdrowia Matki Polki (Iczmp), Lodz, Not set
SPSK4, Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin, Not set
Med Polonia Sp. Z O.O., Poznan, Not set
Maria Sklodowska-Curie National Research Institute of Oncology, Warszawa, Not set
Fundacao Champalimaud, Lisbon, Not set
IPO Porto Francisco Gentil, E.P.E., Porto, Not set
Institute of Oncology Prof. Dr. Ion Chiricuta, Cluj- Napoca, Not set
Onco Clinic Consult Sa, Craiova, Not set
Centrul de Oncologie Sfantu Nectarie, Craiova, Not set
SC Oncomed SRL, Jud Timis, Not set
Oncocenter Oncologie Clinica S.R.L, Timisoara, Not set
Vall Hebron University Hospital, Barcelona, Not set
Hospital Clinic I Provincial de Barcelona, Barcelona, Not set
Hospital Universitario Arnau de Vilanova, Lleida, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Clinico San Carlos, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Regional Universitario Malaga, Malaga, Not set
CHUO, Ourense, Not set
Hosp Univ Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen de Valme, Sevilla, Not set
Hospital Universitario y Politecnico de La Fe, Valenica, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Kantonsspital Baselland, Liestal, Not set
Kantonsspital St. Gallen, St. Gallen, Not set
Spital Sts Ag, Thun, Not set
Changhua Christian Hospital, Changhua, Not set
China Medical University Hospital, Hsia, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Tri-Service General Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital, Taoyuan, Not set
Faculty of Medicine Chulalongkorn University, Bangkok, Not set
Ramathibodi Hospital, Bangkok, Not set
Siriraj Hospital, Bangkok, Not set
Chiang Mai University CMU - Maharaj Nakhon Chiang Mai Hospital Nakorn Chiang Mai Hospital, Chiang Mai, Not set
Prince of Songkla University PSU - Faculty of Medicine, Hat Yai, Not set
Khon Kaen University - Faculty of Medicine-Srinagarind Hospital, Mueang Nonthaburi, Not set
Baskent University, Adana, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Akdeniz University Hospital, Antalya, Not set
Medipol Mega University Hospital, Bağcılar, Not set
Memorial Ankara Hospital, Cankaya/Ankara, Not set
Istanbul Medeniyet University Medical Faculty, Istanbul, Not set
Adana Acibadem Hospital, Seyhan, Not set
Barts Health NHS Trust, London, Not set
Conditions: Metastatic Non Small Cell Lung Cancer
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)
Recruiting
This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma.
This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma. Read Less
Gender:
ALL
Ages:
21 years and below
Trial Updated:
06/25/2025
Locations: Sydney children Hospital, Sydney, Randwick +141 locations
Sydney children Hospital, Sydney, Randwick
Children's Cancer Centre, Monash Children's Hospital, Clayton, Not set
Oncology/Haematology Department, Perth Children's Hospital, Nedlands, Not set
Children's Cancer & Haematology Services, John Hunter Children's Hospital, New Lambton Heights, Not set
Australian and New Zealand Children's Hematology/oncology Group, Sydney, Not set
sydney children Hospital, Sydney, Not set
Cancer Centre for Children, The Children's Hospital, Westmead, Not set
Medical University Graz, Graz, Not set
Landeskrankenhaus-Universitätsklinikum Innsbruck, Innsbruck, Not set
Kepler Universitatsklinikum Linz, Linz, Not set
Universitastsklinikum Salzburg, Salzburg, Not set
St Anna'S Children Hospital, Vienna, Not set
Hôpital Universitaire des Enfants Reine Fabiola (ULB), Brussels, Not set
Cliniques Universitaires Saint-Luc (UCL), Brussel, Not set
University Hospital Gent, Gent, Not set
University Hospitals Leuven, Leuven, Not set
CHR Citadelle, Liège, Not set
University Hospital Motol, Prague,, Prague
Klinika dětské onkologie FN Brno, Brno, Not set
Aarhus University Hospital, Aarhus, Not set
Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Not set
The Hans Christian Andersen Children's Hospital, University of Southern Denmark, Odense, Not set
New Children's Hospital, Helsinki University Hospital, Helsinki and Uusimaa Hospital District, Helsinki, Not set
Kuopio University Hospital, Kuopio, Not set
Oulu University Hospital, Oulu, Not set
Tampere University Hospital, Tampere, Not set
Turku University Hospital, Turku, Not set
Gustave Roussy, Villejuif, Val De Marne
CHU d'AMIENS, Amiens, Not set
CHU angers, Angers, Not set
CHU-Pôle Médico-Chirurgical de l'Enfant et l'Adolescant, Besançon, Not set
CHU Bordeaux, Bordeaux, Not set
Groupe Hospitalier Pellegrin - Chu - Bordeaux, Bordeaux, Not set
CHU Brest, Brest, Not set
CHU Brest - Hôpital du Morvan, Brest, Not set
Centre François Baclesse, Caen, Not set
CHU de Caen, Caen, Not set
CHU Estaing, Clermont-Ferrand, Not set
Centre Georges-François Leclerc, Dijon, Not set
Hopital d'enfants Marechal de lattre, Dijon, Not set
Hôpital Couple-Enfant CHU de Grenoble, Grenoble, Not set
Chu de La Reunion - St Denis, La Réunion, Not set
centre Oscar lambert, Lille, Not set
Hôpital de la Mère et de l'Enfant - CHU Limoges, Limoges, Not set
Centre Léon Berard, Lyon, Not set
hopital la Timone, Marseille, Not set
CHRU Nancy-Hôpital Brabois Enfant, Nancy, Not set
Institut de cancérologie de Loraine, Nancy, Not set
Centre Antoine Lacassagne, Nice, Not set
CHU Nice-Hôpital d'Archet, Nice, Not set
Hôpital Armand Trousseau, Paris, Not set
institut Curie, Paris, Not set
CHU Poitiers, Poitiers, Not set
Hôpital Américain -CHU Reims, Reims, Not set
Centre Eugène Marquis, Rennes, Not set
CHU Rennes, Rennes, Not set
Hôpital des Enfants - CHU Rouen, Rouen, Not set
Institut de cancérologie de l'Ouest - Sité René Gauducheau, Saint-Herblain, Not set
CHU Saint Etienne, Saint-Étienne, Not set
CHU Haute Pierre, Strasbourg, Not set
Institut de Cancérologie Strasbourg, Strasbourg, Not set
Hopital des enfants-CHU Toulouse, Toulouse, Not set
IUCT Oncopole, Toulouse, Not set
CHU Tours Hôpital Clocheville, Tours, Not set
charite universitatsmedizin Berlin, Berlin, Not set
Uniklinik Köln, Klinik und Poliklinik für Kinder und Jugendmedizin, Köln, Not set
Children's General Hospital "I AGHIA SOFIA", Athens, Not set
Children's General Hospital "P. & A. KYRIAKOU", Athens, Not set
"MITERA" Private, General, Obstetrics - Gynaecology, Paediatric Clinic S.A., Athens, Not set
Children's General Hospital "AGHIA SOFIA", Athens, Not set
University General Hospital of Heraklion (UnGHH), Heraklion, Not set
University General Hospital of Thessaloniki "AHEPA", Thessaloniki, Not set
General Hospital of Thessaloniki "IPPOKRATIO", Thessaloniki, Not set
RAMBAM Medical Center, Haifa, Not set
A.O.U Policlinico di Bari, Bari, Not set
Spedali civili Ospedale Dei Bambini Oncoematologia pediatrica e TMO, Brescia, Not set
policlinico rodolico San marco, Catania, Not set
Azienda ospedaliero universtaria Anna Meyer, Firenze, Not set
instituto Giannina Gaslini genova, Genova, Not set
IRCCS "Istituto Giannina Gaslini", Genova, Not set
Azienda Policlinico di Modena, Modena, Not set
Azienda ospedaliero universitaria di Parma, Parma, Not set
Policlino San matteo di Pavia, Pavia, Not set
U.O Pediatria, SS Oncoematologia pediatrica, Rimini, Not set
IRCCS Burlo Garoflo oncoematologia, Trieste, Not set
U.O.C oncoematologia pediatrica ospedale Donna Bambino, Verona, Not set
Vilnius University Hospital Santaros Klinikos, Vilnius, Not set
National Cancer Institute, Vilnius, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Princess Maxima center, Utrecht, Not set
Haukeland University Hospital, Haukeland, Not set
Oslo University Hospital, Oslo, Not set
University Hospital Northern Norway, Tromsoe, Tromsø, Not set
St Olavs Hospital,, Trondheim, Not set
Children's University Hospital Banská Bystrica, Banská Bystrica, Not set
NÚDCH- National Institute of Children's Diseases,, Bratislava, Not set
Children's University Hospital Košice, Košice, Not set
University medical center Ljubljana, University Children's Hospital Ljubljana, Slovenia, Ljubljana, Not set
Hospital Universitario Son Espases, Balea, Not set
Hospital Universitario Vall D´Hebron, Barcelona, Not set
Hospital Universitario Cruces, Cruces, Not set
Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital Universitario Infantil Niño Jesús, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Málaga, Málaga, Not set
Hospital Universitario Donostia, San Sebastián, Not set
Hospital Clínico Universitario de Santiago, Santiago De Compostela, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
Hospital Universitario Politécnico de La FE, Valence, Not set
Sahlgrenska University Hospital, Gothenburg, Not set
Linköping University Hospital, Linköping, Not set
Skåne University Hospital, Lund, Not set
Karolinska University Hospital, Stockholm, Stockholm, Not set
Norrland University Hospital, Umeå, Not set
Uppsala University Hospital, Uppsala, Not set
Kantonsspital Aarau AG Klinik für Kinder und Jugendliche, Aarau, Not set
Universitäts-Kinderspital beider Basel (UKBB), Basel, Not set
Ospedale San Giovanni Pediatria, Emato-oncologia pediatrica, Bellinzona, Not set
Inselspital, Universitätsklinik für Kinderheilkunde, Bern, Not set
HUG Hôpitaux Universitaires de Genève Unité d'Hémato-Oncologie Pédiatrique, Geneva, Not set
CHUV - Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
Luzerner Kantonsspital, Kinderspital pädiatrische Hämatologie/Onkologie, Lucerne, Not set
Ostschweizer Kinderspital Hämatologie/Onkologie Claudiusstrasse 6, Saint Gallen, Not set
Division of Pediatric Oncology Universitäts-Kinderspital Zürich, Zürich, Not set
Royal Aberdeen Children's Hospital, Aberdeen, Not set
Royal Belfast Hospital for Sick Children, Belfast, Not set
Birmingham children's Hospital, Birmingham, Not set
University Hospitals Birmingham Queen Elisabeth Hospital(UHB), Birmingham, Not set
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, Not set
Addenbrookes Hospital, Cambridge, Cambridge, Not set
Noah's Ark Children's Hospital for Wales - Cardiff, Cardiff, Not set
Royal Hospital for Sick Children - Edinburgh, Edinburgh, Not set
Royal Hospital for Children Glasgow, Glasgow, Not set
Leeds General Infirmary, Leeds, Not set
Alder Hey Children's Hospital - Liverpool, Liverpool, Not set
Great Ormond Street Hospital - London, London, Not set
Royal Manchester Children's Hospital, Manchester, Not set
Royal Victoria Infirmary, Newcastle, Newcastle, Not set
Nottingham Children's Hospital, Nottingham, Not set
Sheffield Children's Hospital, Sheffield, Not set
Southampton General Hospital, Southampton, Not set
Royal Marsden Hospital, Sutton, Not set
Conditions: High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy
Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)
Recruiting
This is a global, multicenter, randomized, open-label study, with an adaptive design. The main objective of the study is to measure the efficacy and safety of BT8009 (zelenectide pevedotin) as monotherapy and in combination with pembrolizumab in participants with locally advanced or metastatic urothelial cancer (UC). The study includes a dose selection phase followed by an adaptive design continuation. The study is comprised of 2 cohorts. Cohort 1 will include participants who have not received... Read More
This is a global, multicenter, randomized, open-label study, with an adaptive design. The main objective of the study is to measure the efficacy and safety of BT8009 (zelenectide pevedotin) as monotherapy and in combination with pembrolizumab in participants with locally advanced or metastatic urothelial cancer (UC). The study includes a dose selection phase followed by an adaptive design continuation. The study is comprised of 2 cohorts. Cohort 1 will include participants who have not received any prior systemic therapy for locally advanced or metastatic UC and are eligible to receive platinum-based chemotherapy, whereas Cohort 2 will include participants who have received ≥ 1 prior systemic therapy for locally advanced or metastatic UC. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +169 locations
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Virginia K. Crosson Cancer Center at St. Jude Medical Center, Fullerton, California
University of California - Irvine Medical Center, Orange, California
Adventist Health St. Helena, Saint Helena, California
University of California, San Francisco (UCSF), San Francisco, California
Rocky Mountain Cancer Center, Denver, Colorado
Yale University School of Medicine - Yale Cancer Center, New Haven, Connecticut
Medical Oncology Hematology Consultants, Newark, Delaware
Cancer Specialists of North Florida, Jacksonville, Florida
Mount Sinai Medical Center of Florida, Inc., Miami Beach, Florida
University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida
AP Medical Research, Miami, Florida
Moffitt, Tampa, Florida
Southern Illinois University (SIU) - Simmons Cancer Institute, Springfield, Illinois
Mission Cancer + Blood, Des Moines, Iowa
University of Kansas Cancer Center, Westwood, Kansas
UofL Health Brown Cancer Center, Louisville, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Princess Margaret Hospital, Grand Rapids, Michigan
Nebraska Cancer Specialists, Omaha, Nebraska
XCancer Omaha/Urology Cancer Center, Omaha, Nebraska
Astera Cancer Care, East Brunswick, New Jersey
Summit Health (New Jersey Urology), Voorhees, New Jersey
Montefiore Medical Center, Bronx, New York
Columbia University Irving Medical Center, New York, New York
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Medical University of South Carolina (MUSC) - Hollings Cancer Center, Charleston, South Carolina
Carolina Urologic Research Center, Myrtle Beach, South Carolina
SCRI Oncology Partners, Nashville, Tennessee
The Center for Cancer and Blood Disorders, Fort Worth, Texas
MD Anderson Cancer Center, Houston, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Centro de Diagnostico Urologico S.R.L., Buenos Aires, Not set
Hospital Britanico de Buenos Aires, Buenos Aires, Not set
Hospital Sirio Libanes de Buenos Aires, Buenos Aires, Not set
Instituto Alexander Fleming, Buenos Aires, Not set
Fundacion Medica Rio Negro y Neuquen, Cipolletti, Not set
Centro Medico Privado (CEMAIC), Córdoba, Not set
Fundación CORI para la investigación y Prevención del Cancer, La Rioja, Not set
Centro De Investigacion Pergamino S.A., Pergamino, Not set
Instituto de Oncologia de Rosario, Santa Fe, Not set
Clinica Viedma S.A., Viedma, Not set
Cancer Research SA, Adelaide, Not set
Mater Misericordiae Ltd, South Brisbane, Brisbane, Not set
Townsville Hospital and Health Service, Douglas, Not set
Barwon Health, Geelong, Not set
Calvary Mater Newcastle, Hunter, Not set
Sir Charles Gairdner Hospital, Nedlands, Not set
Blacktown Hospital, New South Wales, Not set
Prince of Wales Hospital, Randwick, Not set
Icon Cancer Centre, South Brisbane, Not set
Gold Coast University Hospital, Southport, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Urologie und Andrologie Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
Krankenhaus der Barmherzigen Brüder Wien, Wien, Not set
Medizinische Universitaet Wien, Wien, Not set
ASBL Grand Hôpital de Charleroi (GHdC), Site Notre Dame, Charleroi, Not set
General Hospital Maria Middelares, Gent, Not set
University Hospital Gent, Gent, Not set
Universitaire Ziekenhuizen Leuven, Leuven, Not set
Fundacao PIO XII - Hospital de Amor, Barretos, Not set
CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina, Florianópolis, Not set
Oncosite - Centro de Pesquisa Clinica Em Oncologia, Ijuí, Not set
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa, Porto Alegre, Not set
Hospital Sao Lucas - Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, Not set
Hospital Alemao Oswaldo Cruz, São Paulo, Not set
Hospital A.C. Camargo Cancer Center, São Paulo, Not set
British Columbia Cancer Agency- Centre for the Southern Interior, Kelowna, Not set
McGill University Health Center, Québec, Not set
Princess Margaret Hospital, Toronto, Not set
Cancer Care Manitoba, Winnipeg, Not set
Fundación Arturo López Pérez (FALP), Santiago, Not set
Centro de Investigacion Clinica Bradford Hill, Santiago, Not set
Oncocentro APYS, Viña Del Mar, Not set
Aalborg University Hospital, Aalborg, Not set
Service d'Oncologie Medicale - CHRU Besancon, Besançon, Not set
Institut Bergonie, Bordeaux Cedex, Not set
CHU Bordeaux - Hopital Saint-Andre, Bordeaux, Not set
Groupement de Cooperation Sanitaire (GCS) ELSAN - Clinique Victor Hugo, Le Mans, Not set
CHU de Limoges - Hopital Dupuytren 1, Limoges, Not set
Centre Leon Berard, Lyon, Not set
Institut Paoli-Calmettes, Marseille, Not set
ICM - Institut Regional du Cancer de Montpellier, Montpellier Cedex 5, Not set
Centre d'Oncologie de Gentilly, Nancy, Not set
Centre Antoine-Lacassagne, Nice, Not set
Institut Mutualiste Montsouris, Paris, Not set
AP-HP Hopital Europeen Georges Pompidou, Paris, Not set
HCL Centre Hospitalier Lyon Sud, Pierre-Benite Cedex, Not set
CHU Poitiers - Pole Regional de Cancerologie de Poitiers (PRC), Poitiers, Not set
Institut Gustave Roussy, Villejuif, Not set
LTD High Technology Hospital Medcenter, Batumi, Not set
The First University Clinic of Tbilisi State Medical University, Tbilisi, Not set
New Vision University Hospital, Tbilisi, Not set
Multiprofile Clinic Consilium Medulla LTD, Tbilisi, Not set
Universitaetsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Universitaetsklinikum Essen, Essen, Not set
Krankenhaus Nordwest GmbH, Frankfurt, Not set
Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe Universitaet, Frankfurt, Not set
Universitaetsklinikum Freiburg, Freiburg, Not set
Georg-August-Universitaet Goettingen Stiftung oeffentlichen Rechts Universitaetsmedizin Goettingen, Göttingen, Not set
Marien Hospital Herne - Universitaetsklinikum der Ruhr-Universitaet Bochum, Herne, Not set
Universitaetsmedizin Mannheim, Mannheim, Not set
Universitaetsklinikum Muenster, Münster, Not set
Studienpraxis Urologie, Nürtingen, Not set
Universitaetsklinikum Tuebingen, Tübingen, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Budapesti Uzsoki Utcai Korhaz, Budapest, Not set
Somogy Varmegyei Kaposi Mor Oktato Korhaz, Kaposvár, Not set
Bacs-Kiskun Varmegyei Oktatokorhaz, Kecskemét, Not set
Shamir Medical Center, Be'er Ya'aqov, Not set
Rambam Health Care Campus, Haifa, Not set
Hadassah Hebrew University Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Rabin Medical Center - Beilinson Hospital, Petach Tikva, Not set
Sourasky Medical Center, Tel Aviv, Not set
Centro Riferimento Oncologico - Aviano, Aviano, Not set
Ospedale Policlinico San Martino IRCCS, Genova, Not set
Istituto Europeo di Oncologia, Milano, Not set
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Napoli, Not set
Azienda Ospedaliera Santa Maria di Terni, Terni, Not set
Chungnam National University Hospital, Daejeon, Not set
National Cancer Center, Goyang, Not set
Chonnam National University Hwasun Hospital, Gwangju, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Copernicus PL Sp. z o.o., Wojewodzkie Centrum Onkologii, Gdańsk, Not set
Spitale Pomorskie Sp.z.o.o ODDZIAL ONKOLOGII KLINICZNEJ, Gdynia, Not set
SCM Sp. z o.o., Kraków, Not set
Mazowiecki Szpital Onkologiczny, Wieliszew, Not set
University Clinical Center of Serbia, Clinic of Urology, Belgrade, Not set
National University Hospital, Singapore, Not set
National Cancer Centre Singapore, Singapore, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Institut Catala d'Oncologia - L'Hospitalet, Barcelona, Not set
Hospital Universitario Insular de Gran Canaria, Las Palmas De Gran Canaria, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Clinica Universidad de Navarra - Madrid, Madrid, Not set
Hospital Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Clinica Universidad de Navarra - Pamplona, Pamplona, Not set
Hospital Universitario Donostia, San Sebastián, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Hospital Clinico Universitario de Santiago, Santiago De Compostela, Not set
Instituto Valenciano de Oncologia, Valencia, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
Chi Mei Medical Center, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital (CGMHLK), Taoyuan city, Not set
Liv Hospital Ankara, Ankara, Not set
Trakya University Medical Faculty, Edirne, Not set
Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Not set
Istinye Universitesi VM Medical Park Pendik Hastanesi, Istanbul, Not set
Medical Point Izmir Hospital, İzmir, Not set
Kocaeli University Faculty of Medicine, Kocaeli, Not set
Bristol Haematology and Oncology Centre, Bristol, Not set
Addenbrooke's Hospital, Cambridge, Not set
St. Bartholomew's Hospital, London, Not set
University College London Hospital, London, Not set
Royal Free London NHS Foundation Trust, London, Not set
Charing Cross Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Derriford Hospital, Plymouth, Not set
The Royal Marsden Hospital, Sutton, Not set
Conditions: Metastatic Urothelial Cancer
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
Recruiting
This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in participants with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring first-line systemic therapy.
This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in participants with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring first-line systemic therapy. Read Less
Gender:
ALL
Ages:
25 years and below
Trial Updated:
06/18/2025
Locations: Children's of Alabama, Birmingham, Alabama +122 locations
Children's of Alabama, Birmingham, Alabama
Phoenix Children's Hospital, Phoenix, Arizona
Children's Hospital Los Angeles, Los Angeles, California
Children's Hospital of Orange County Main Campus - Orange, Orange, California
UCSF Benioff Children's Hospital, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Children's National Medical Center, Washington, District of Columbia
University of Florida Health, Gainesville, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Johns Hopkins All Children's Hospital, St. Petersburg, Florida
Children's Healthcare of Atlanta, Atlanta, Georgia
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana
Maine Children's Cancer Program, Scarborough, Maine
Dana-Farber Cancer Institute, Boston, Massachusetts
University of Michigan - - C.S. Mott Children's Hospital, Ann Arbor, Michigan
Children's Minnesota, Minneapolis, Minnesota
St. Louis Children's Hospital, Saint Louis, Missouri
University of Nebraska Medical Center, Omaha, Nebraska
New York University Langone Health, New York, New York
University of Rochester, Rochester, New York
Duke Cancer Institute, Durham, North Carolina
Cleveland Clinic Main Campus, Cleveland, Ohio
University of Texas Southwestern Medical Center, Dallas, Texas
Texas Children's Hospital, Houston, Texas
Seattle Children's Hospital, Seattle, Washington
University of Wisconsin - Madison, Madison, Wisconsin
Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland
Perth Children's Hospital, Nedlands, Not set
Women's and Children's Health Network, North Adelaide, Not set
The Royal Children's Hospital - Children's Cancer Centre, Parkville, Not set
Sydney Children's Hospital - Randwick, Randwick, Not set
Children's Hospital at Westmead, Westmead, Not set
Medizinische Universität Innsbruck, Innsbruck, Tirol
Medizinische Universität Wien, Wien, Not set
Cliniques Universitaires Saint-Luc, Brussel, Not set
Universitair Ziekenhuis Gent, Ghent, Not set
Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Not set
Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), São Paulo, Not set
Alberta Children's Hospital, Calgary, Alberta
Stollery Children's Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
McMaster Children's Hospital, Hamilton, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
CHU Sainte-Justine, Montréal, Quebec
The Montreal Children's Hospital, Montréal, Quebec
Centre Hospitalier de l'Université Laval et Centre Mère-Enfant Soleil, Québec, Not set
SickKids - The Hospital for Sick Children, Toronto, Not set
Fakultní Nemocnice Brno - D?tská Nemocnice, Brno, Not set
Motol University Hospital, Prague, Not set
Aarhus Universitetshospital, Aarhus, Midtjylland
Rigshospitalet, Copenhagen, Not set
Helsingin yliopistollinen sairaala (HUS), Helsinki, Not set
Tampereen Yliopistollinen Sairaala, Tampere, Not set
Centre de Lutte contre le Cancer - Centre Oscar Lambret, Lille, Not set
Centre Léon Bérard, Lyon, Not set
Hôpital de la Timone, Marseille, Not set
Institut Curie, Paris, Not set
Gustave Roussy, Villejuif, Not set
Universitätsklinikum Freiburg, Freiburg, Baden-Württemberg
Universitätsklinikum Augsburg, Augsburg, Bayern
Universitätsklinikum Erlangen, Erlangen, Bayern
Universitätsklinikum Würzburg, Würzburg, Bayern
Universitätsklinikum Frankfurt, Frankfurt, Hessen
Medizinische Hochschule Hannover, Hannover, Niedersachsen
Universitaetsklinikum Essen, Essen, Nordrhein-Westfalen
Universitätsklinikum Leipzig, Leipzig, Sachsen
Charité Universitätsmedizin Berlin, Berlin, Not set
Evangelische Klinikum Bethel (EvKB), Bielefeld, Not set
Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set
Universitätsklinikum Heidelberg, Heidelberg, Not set
Universitätsklinikum Tübingen, Tübingen, Not set
Aghia Sofia General Children's Hospital, Athens, Not set
Athens General Children's Hospital, Athens, Not set
Semmelweis Egyetem Tűzoltó utcai II. Sz. Gyermekgyógyászati Kliniká, Budapest, Not set
Children's Health Ireland at Crumlin, Crumlin, Dublin
Schneider Children's Medical Center of Israel, Petah tikva, Not set
The Edmond and Lily Safra Children's Hospital, Ramat Gan, Not set
Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Milan
Ospedale Pediatrico Bambino Gesù, Roma, Rome
Ospedale Infantile Regina Margherita, Torino, Turin
Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari, Bari, Not set
Istituto Giannina Gaslini, Genova, Not set
Azienda Ospedaliera di Rilievo Nazional Santobono Pausilipon, Napoli, Not set
Azienda Ospedale Università di Padova, Padova, Not set
Azienda Sanitaria Universitaria Friuli Centrale - P.O. Santa Maria della Misericordia, Udine, Not set
King Hussein Cancer Foundation - King Hussein Cancer Center, Amman, Muhafazat al-Asima
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
Prinses Maxima Centrum Kinderoncologie, Utrecht, Not set
Starship Paediatric Blood & Cancer Center, Grafton, Not set
Universitetssykehuset Nord-Norge - Tromsø, Tromsø, Troms
Oslo Universitetssykehus, Oslo, Not set
SingHealth Group - KK Women's and Children's Hospital, Singapore, Not set
Univerzitetni Klinini Center Ljubljana, Ljubljana, Not set
Hospital Universitario Cruces, Barakaldo, Not set
Hospital Universitari Vall d'Hebrón, Barcelona, Not set
Hospital Sant Joan de Déu Barcelona, Barcelona, Not set
Hospital Infantil Universitario Niño Jesús, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
Hospital Universitari i Politècnic La Fe, Valencia, Not set
Drottning Silvias barn- och ungdomssjukhus, Göteborg, Not set
Skånes Universitetssjukhus - Lund, Lund, Not set
Astrid Lindgrens Barnsjukhus Solna, Stockholm, Not set
Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Not set
Universitaets - Kinderspital Zürich, Zurich, Not set
Taipei Medical University Hospital, Taipei, Not set
Chang Gung Memorial Hospital - Linkou Branch, Taoyuan, Not set
Birmingham Women's and Children's NHS Foundation Trust, Birmingham, England
Leeds Teaching Hospital NHS Trust, Leeds, England
Alder Hey Children's NHS Foundation Trust, Liverpool, England
Manchester University NHS Foundation Trust, Manchester, England
The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, England
Great Ormond Street Hospital for Children, Oxford, England
University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire
Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland
NHS Greater Glasgow and Clyde, Glasgow, Scotland
Sheffield Children's Hospital, Sheffield, South Yorkshire
The Royal Marsden NHS Foundation Trust, Sutton, Surrey
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, Not set
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Not set
Conditions: Low-grade Glioma, Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma, Pediatric Low-grade Glioma
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors
Recruiting
A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL \[LN-144/LN-145 (lifileucel)\] in combination with immune checkpoint inhibitors or TIL \[LN-144/LN-145 (lifileucel) and LN-145-S1\] as a single agent therapy.
A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL \[LN-144/LN-145 (lifileucel)\] in combination with immune checkpoint inhibitors or TIL \[LN-144/LN-145 (lifileucel) and LN-145-S1\] as a single agent therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: University of California, San Diego, La Jolla, California +44 locations
University of California, San Diego, La Jolla, California
University of Southern California, Los Angeles, California
University of California, Los Angeles, Los Angeles, California
University of Colorado, Denver, Colorado
Yale University, New Haven, Connecticut
Georgetown University Medical Center, Washington, District of Columbia
Mount Sinai Medical Center, Miami Beach, Florida
Orlando Health Cancer Institute, Orlando, Florida
Moffitt Cancer Center, Tampa, Florida
University of Louisville, Louisville, Kentucky
University of Maryland, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health System, Detroit, Michigan
MD Anderson at Cooper, Camden, New Jersey
Morristown Medical Center, Morristown, New Jersey
Columbia University, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Cincinnati, Cincinnati, Ohio
Ohio State University, Columbus, Ohio
Avera Cancer Institute, Sioux Falls, South Dakota
Huntsman Cancer Hospital, Salt Lake City, Utah
Fred Hutchinson Cancer Research Center, Seattle, Washington
Medical College of Wisconsin, Milwaukee, Wisconsin
Princess Margaret Cancer Centre, Toronto, Ontario
Centre Léon Berard, Lyon, Not set
Klinikum rechts der Isar der Technischen Universität München, München, Bavaria
Universitätsklinikum Carl Gustav Carus, Dresden, Sachsen
Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck, Schleswig-Holstein
Laiko General Hospital of Athens, Athens, Attiki
Attikon University General Hospital, Athens, Attiki
Hospital Universitario Marques de Valdecilla, Santander, Cantabria
University Hospital Vall d'Hebron, Barcelona, Not set
ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario HM Sanchinarro, Madrid, Not set
Hospital Regional Universitario de Malaga - Hospital General, Málaga, Not set
Universitätsspital Basel, Basel, Not set
Universitaetsspital Bern, Bern, Not set
Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
Guy's Hospital, London, England
The Royal Marsden NHS Foundation Trust, London, England
Bristol Haematology and Oncology Centre, Bristol, Not set
Conditions: Metastatic Melanoma, Squamous Cell Carcinoma of the Head and Neck, Non-small Cell Lung Cancer
Ascending Doses of Ceralasertib in Combination With Chemotherapy and/or Novel Anti Cancer Agents
Active Not Recruiting
This is a modular, phase I/ phase 1 b, open-label, multicentre study of ceralasertib administered orally in combination with cytotoxic chemotherapy regimens and/or novel anti-cancer agents, to patients with advanced malignancies. The study design allows an investigation of optimal combination dose of ceralasertib with other anti-cancer treatments, with intensive safety monitoring to ensure the safety of the patients. The initial combination to be investigated is ceralasertib with carboplatin. Th... Read More
This is a modular, phase I/ phase 1 b, open-label, multicentre study of ceralasertib administered orally in combination with cytotoxic chemotherapy regimens and/or novel anti-cancer agents, to patients with advanced malignancies. The study design allows an investigation of optimal combination dose of ceralasertib with other anti-cancer treatments, with intensive safety monitoring to ensure the safety of the patients. The initial combination to be investigated is ceralasertib with carboplatin. The second combination to be investigated is ceralasertib with Olaparib. The third combination to be investigated is ceralasertib with durvalumab. The fourth module will investigate the effect of food on ceralasertib absorption and the effect of ceralasertib on ECG parameter. The fifth module to be investigated is ceralasertib with AZD5305. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
06/13/2025
Locations: Research Site, Duarte, California +27 locations
Research Site, Duarte, California
Research Site, Irvine, California
Research Site, Los Angeles, California
Research Site, Los Angeles, California
Research Site, Newport Beach, California
Research Site, Boston, Massachusetts
Research Site, New York, New York
Research Site, Philadelphia, Pennsylvania
Research Site, Bordeaux, Not set
Research Site, Lyon Cedex 08, Not set
Research Site, Saint Herblain, Not set
Research Site, Villejuif, Not set
Research Site, Goyang-si, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Bristol, Not set
Research Site, Cambridge, Not set
Research Site, Coventry, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Oxford, Not set
Research Site, Sutton, Not set
Research Site, Withington, Not set
Conditions: Adv Solid Malig - H&N SCC, ATM Pro / Def NSCLC, Gastric, Breast and Ovarian Cancer
Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
Active Not Recruiting
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy + Standard of care (SoC) chemotherapy or durvalumab monotherapy + SoC chemotherapy versus SoC chemotherapy alone as first line treatment in patients with metastatic non small-cell lung cancer (NSCLC) with tumors that lack activating epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) fusions.
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy + Standard of care (SoC) chemotherapy or durvalumab monotherapy + SoC chemotherapy versus SoC chemotherapy alone as first line treatment in patients with metastatic non small-cell lung cancer (NSCLC) with tumors that lack activating epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) fusions. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
06/11/2025
Locations: Research Site, Phoenix, Arizona +174 locations
Research Site, Phoenix, Arizona
Research Site, Bakersfield, California
Research Site, Santa Monica, California
Research Site, Fort Myers, Florida
Research Site, Jacksonville, Florida
Research Site, Saint Petersburg, Florida
Research Site, West Palm Beach, Florida
Research Site, Louisville, Kentucky
Research Site, Kansas City, Missouri
Research Site, Canton, Ohio
Research Site, Pittsburgh, Pennsylvania
Research Site, Chattanooga, Tennessee
Research Site, Nashville, Tennessee
Research Site, Fort Worth, Texas
Research Site, Houston, Texas
Research Site, Richmond, Virginia
Research Site, Barretos, Not set
Research Site, Belo Horizonte, Not set
Research Site, Curitiba, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Ribeirao Preto, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Santo Andre, Not set
Research Site, Santo André, Not set
Research Site, Sao Paulo, Not set
Research Site, São José do Rio Preto, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Plovdiv, Not set
Research Site, Plovdiv, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Varna, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Fuzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Hefei, Not set
Research Site, Kunming, Not set
Research Site, Linyi, Not set
Research Site, Liuzhou, Not set
Research Site, Nanjing, Not set
Research Site, Qingdao, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shantou, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xining, Not set
Research Site, Yangzhou, Not set
Research Site, Zhanjiang, Not set
Research Site, Zhengzhou, Not set
Research Site, Zhengzhou, Not set
Research Site, Berlin, Not set
Research Site, Essen, Not set
Research Site, Freiburg, Not set
Research Site, Gauting, Not set
Research Site, Hamburg, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Immenhausen, Not set
Research Site, Mainz, Not set
Research Site, Oldenburg, Not set
Research Site, Würzburg, Not set
Research Site, Shatin, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Kecskemét, Not set
Research Site, Miskolc, Not set
Research Site, Törökbálint, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Chuo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Iwakuni-shi, Not set
Research Site, Kanazawa, Not set
Research Site, Kashiwa, Not set
Research Site, Koto-ku, Not set
Research Site, Kurume-shi, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osakasayama, Not set
Research Site, Sapporo-shi, Not set
Research Site, Sunto-gun, Not set
Research Site, Toyoake-shi, Not set
Research Site, Ube-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Busan, Not set
Research Site, Chungcheongbuk-do, Not set
Research Site, Daegu, Not set
Research Site, Incheon, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Ulsan, Not set
Research Site, Aguascalientes, Not set
Research Site, Cuautitlan Izcalli, Not set
Research Site, Guadalajara, Not set
Research Site, Mexico City, Not set
Research Site, Mexico, Not set
Research Site, Monterrey, Not set
Research Site, Monterrey, Not set
Research Site, México, Not set
Research Site, Tuxtla, Not set
Research Site, Arequipa, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, San Isidro, Not set
Research Site, Olsztyn, Not set
Research Site, Tomaszów Mazowiecki, Not set
Research Site, Warszawa, Not set
Research Site, Wodzisław Śląski, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Omsk, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint-Petersburg, Not set
Research Site, Sankt-Peterburg, Not set
Research Site, St. Petersburg, Not set
Research Site, Cape Town, Not set
Research Site, Durban, Not set
Research Site, Johannesburg, Not set
Research Site, Parktown, Not set
Research Site, Pretoria, Not set
Research Site, Rondebosch, Not set
Research Site, Vereeniging, Not set
Research Site, Changhua City, Not set
Research Site, Kaohsiung City, Not set
Research Site, Kaohsiung, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Tainan, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Tao-Yuan, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Muang, Not set
Research Site, Songkhla, Not set
Research Site, Dnipro, Not set
Research Site, Ivano-Frankivsk, Not set
Research Site, Kirovohrad, Not set
Research Site, Kyiv, Not set
Research Site, Kyiv, Not set
Research Site, Lviv, Not set
Research Site, Odesa, Not set
Research Site, Sumy, Not set
Research Site, Vinnytsia, Not set
Research Site, Zaporizhzhia, Not set
Research Site, Leicester, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Hanoi, Not set
Research Site, Ho Chi Minh, Not set
Conditions: Non Small Cell Lung Cancer NSCLC
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
Active Not Recruiting
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy versus platinum-based SoC chemotherapy in the first-line treatment of patients with epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type advanced or metastatic NSCLC.
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy versus platinum-based SoC chemotherapy in the first-line treatment of patients with epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type advanced or metastatic NSCLC. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
06/06/2025
Locations: Research Site, Anaheim, California +210 locations
Research Site, Anaheim, California
Research Site, San Diego, California
Research Site, Santa Rosa, California
Research Site, Louisville, Kentucky
Research Site, Florham Park, New Jersey
Research Site, Albuquerque, New Mexico
Research Site, East Setauket, New York
Research Site, Fresh Meadows, New York
Research Site, Poughkeepsie, New York
Research Site, Stony Brook, New York
Research Site, Canton, Ohio
Research Site, Columbus, Ohio
Research Site, Zanesville, Ohio
Research Site, Pittsburgh, Pennsylvania
Research Site, Houston, Texas
Research Site, Berazategui, Not set
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, Córdoba, Not set
Research Site, La Rioja, Not set
Research Site, Rosario, Not set
Research Site, San Salvador de Jujuy, Not set
Research Site, Santa Rosa, Not set
Research Site, Barretos, Not set
Research Site, Belo Horizonte, Not set
Research Site, Belo Horizonte, Not set
Research Site, Fortaleza, Not set
Research Site, Ijui, Not set
Research Site, Itajai, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, São José do Rio Preto, Not set
Research Site, São Paulo, Not set
Research Site, Plovdiv, Not set
Research Site, Shumen, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Varna, Not set
Research Site, Vratza, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Temuco, Not set
Research Site, Viña del Mar, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Urumqi, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Odense C, Not set
Research Site, Oulu, Not set
Research Site, Tampere, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Heraklion, Not set
Research Site, Holargos, Athens, Not set
Research Site, Ioannina, Not set
Research Site, Hong Kong, Not set
Research Site, King's Park, Not set
Research Site, Shatin, Not set
Research Site, Ahmedabad, Not set
Research Site, Bangalore, Not set
Research Site, Bangalore, Not set
Research Site, Chennai, Not set
Research Site, Gurgaon, Not set
Research Site, Karamsad, Not set
Research Site, New Delhi, Not set
Research Site, Beer Sheva, Not set
Research Site, Jerusalem, Not set
Research Site, Kfar Saba, Not set
Research Site, Nahariya, Not set
Research Site, Petah Tikva, Not set
Research Site, Ramat Gan, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Fukushima-shi, Not set
Research Site, Habikino-shi, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Iizuka-shi, Not set
Research Site, Iwakuni-shi, Not set
Research Site, Kanazawa, Not set
Research Site, Kishiwada-shi, Not set
Research Site, Kobe-shi, Not set
Research Site, Kurume-shi, Not set
Research Site, Kyoto-shi, Not set
Research Site, Mitaka-shi, Not set
Research Site, Nagaoka-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Niigata-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Saga-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sakai-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Tokushima-shi, Not set
Research Site, Ube-shi, Not set
Research Site, Wakayama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Daegu, Not set
Research Site, Hwasun-gun, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuantan, Not set
Research Site, Kuching, Not set
Research Site, Acapulco, Not set
Research Site, Aguascalientes, Not set
Research Site, Mexico, Not set
Research Site, Monterrey, Not set
Research Site, Mérida, Not set
Research Site, México, Not set
Research Site, Arequipa, Not set
Research Site, Bellavista, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Baguio City, Not set
Research Site, Cebu, Not set
Research Site, Las Pinas City, Not set
Research Site, Manila, Not set
Research Site, Manila, Not set
Research Site, Quezon City, Not set
Research Site, Bydgoszcz, Not set
Research Site, Kielce, Not set
Research Site, Kraków, Not set
Research Site, Mrozy, Not set
Research Site, Olsztyn, Not set
Research Site, Poznan, Not set
Research Site, Poznań, Not set
Research Site, Warszawa, Not set
Research Site, Warszawa, Not set
Research Site, Wodzisław Śląski, Not set
Research Site, Łódź, Not set
Research Site, Amadora, Not set
Research Site, Lisboa, Not set
Research Site, Porto, Not set
Research Site, Porto, Not set
Research Site, Porto, Not set
Research Site, Doha, Not set
Research Site, Suceava, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Omsk, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint-Petersburg, Not set
Research Site, Saint-Petersburg, Not set
Research Site, St. Petersburg, Not set
Research Site, Dammam, Not set
Research Site, Riyadh, Not set
Research Site, Riyadh, Not set
Research Site, Singapore, Not set
Research Site, Singapore, Not set
Research Site, Singapore, Not set
Research Site, Singapore, Not set
Research Site, Eskilstuna, Not set
Research Site, Linköping, Not set
Research Site, Stockholm, Not set
Research Site, Uppsala, Not set
Research Site, Adana, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Izmir, Not set
Research Site, Chernivtsі, Not set
Research Site, Dnipro, Not set
Research Site, Ivano-Frankivsk, Not set
Research Site, Kapitanivka Village, Not set
Research Site, Kharkiv Region, Not set
Research Site, Kirovohrad, Not set
Research Site, Kyiv, Not set
Research Site, Kyiv, Not set
Research Site, Lviv, Not set
Research Site, Lyutizh, Not set
Research Site, Odesa, Not set
Research Site, Sumy, Not set
Research Site, Uzhhorod, Not set
Research Site, Vinnytsia, Not set
Research Site, Guildford, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Nottingham, Not set
Research Site, Taunton, Not set
Research Site, Wirral, Not set
Research Site, Wolverhampton, Not set
Conditions: Non Small Cell Lung Carcinoma NSCLC
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
Active Not Recruiting
The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary hypotheses are that pembrolizumab + adjuvant chemotherapy is superior to placebo + adjuvant chemotherapy, with or without radiotherapy, wi... Read More
The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary hypotheses are that pembrolizumab + adjuvant chemotherapy is superior to placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to DFS as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to OS. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/05/2025
Locations: University of Alabama - Birmingham ( Site 3061), Birmingham, Alabama +230 locations
University of Alabama - Birmingham ( Site 3061), Birmingham, Alabama
University of South Alabama, Mitchell Cancer Institute ( Site 3058), Mobile, Alabama
HonorHealth Research Institute - Biltmore ( Site 3043), Phoenix, Arizona
Arizona Oncology Associates PC- HOPE ( Site 3049), Tucson, Arizona
UCSD Moores Cancer Center ( Site 3053), La Jolla, California
University Of Colorado ( Site 3051), Aurora, Colorado
Smilow Cancer Hospital at Yale New Haven ( Site 3070), New Haven, Connecticut
Mount Sinai Cancer Center ( Site 3081), Miami Beach, Florida
Northside Hospital ( Site 3036), Atlanta, Georgia
Northwestern Memorial Hospital ( Site 3044), Chicago, Illinois
Parkview Cancer Institute ( Site 3067), Fort Wayne, Indiana
Indiana University Melvin and Bren Simon Cancer Center ( Site 3071), Indianapolis, Indiana
University of Iowa Hospital and Clinics ( Site 3046), Iowa City, Iowa
Norton Cancer Institute - St. Matthews ( Site 3056), Louisville, Kentucky
WK Physicians Network/Gynecologic Oncology Associates ( Site 3047), Shreveport, Louisiana
University of Massachusetts Medical School ( Site 3037), Worcester, Massachusetts
Montefiore Medical Center ( Site 3065), Bronx, New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 3076), Mineola, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 3042), New York, New York
Duke Cancer Center ( Site 3072), Durham, North Carolina
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 3080), Fargo, North Dakota
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C, Columbus, Ohio
Legacy Good Samaritan Medical Center ( Site 3033), Portland, Oregon
Sidney Kimmel Cancer Center - Jefferson Health ( Site 3078), Philadelphia, Pennsylvania
AHN West Penn Hospital ( Site 3060), Pittsburgh, Pennsylvania
Abington Hospital - Asplundh Cancer Center ( Site 3073), Willow Grove, Pennsylvania
Sanford Gynecology Oncology ( Site 3045), Sioux Falls, South Dakota
UT Southwestern Medical Center ( Site 3063), Dallas, Texas
VCU Massey Cancer Center ( Site 3068), Richmond, Virginia
Centro de Oncología e Investigación de Buenos Aires ( Site 1005), Berazategui, Buenos Aires
IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 1006), Caba, Buenos Aires
Instituto de Investigaciones Clinicas Mar del Plata ( Site 1003), Mar del Plata, Buenos Aires
Hospital Britanico de Buenos Aires ( Site 1002), Buenos Aires, Caba
Instituto de Oncologia de Rosario ( Site 1004), Rosario, Santa Fe
IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas ( Site 1010), Buenos Aires, Not set
Hospital Aleman ( Site 1001), Buenos Aires, Not set
CEMIC ( Site 1009), Buenos Aires, Not set
Centro Oncologico Riojano Integral ( Site 1007), La Rioja, Not set
Medizinische Universitat Graz ( Site 2004), Graz, Steiermark
Medizinische Universitaet Innsbruck ( Site 2001), Innsbruck, Tirol
Saint-Luc UCL ( Site 2042), Bruxelles, Bruxelles-Capitale, Region De
C.I.U. Hopital Ambroise Pare ( Site 2039), Mons, Hainaut
CHR Verviers ( Site 2035), Verviers, Liege
OLV Ziekenhuis ( Site 2038), Aalst, Oost-Vlaanderen
AZ Maria Middelares Gent ( Site 2032), Gent, Oost-Vlaanderen
Universitair Ziekenhuis Gent ( Site 2037), Gent, Oost-Vlaanderen
AZ Nikolaas ( Site 2031), Sint-Niklaas, Oost-Vlaanderen
UZ Leuven ( Site 2040), Leuven, Vlaams-Brabant
AZ Groeninge ( Site 2036), Kortrijk, West-Vlaanderen
CHC - Groupe Sante ( Site 2041), Liege, Not set
CHU Liege Sart-Tilman ( Site 2044), Liege, Not set
Tom Baker Cancer Centre ( Site 3007), Calgary, Alberta
Kingston Health Sciences Centre ( Site 3003), Kingston, Ontario
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 3006), Montreal, Quebec
McGill University Health Centre ( Site 3005), Montreal, Quebec
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 3, Quebec City, Quebec
Centro Investigación del Cáncer James Lind ( Site 1061), Temuco, Araucania
Fundacion Arturo Lopez Perez FALP ( Site 1062), Santiago, Region M. De Santiago
Centro de Cancer Nuestra Senora de la Esperanza ( Site 1063), Santiago, Region M. De Santiago
Bradfordhill-Clinical Area ( Site 1070), Santiago, Region M. De Santiago
Oncocentro ( Site 1065), Vina del Mar, Valparaiso
Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 4034), Hefei, Anhui
Beijing Cancer Hospital ( Site 4048), Beijing, Beijing
Peking Union Medical College Hospital ( Site 4036), Beijing, Beijing
Chongqing Cancer Hospital ( Site 4040), Chongqing, Chongqing
The First Affiliated Hospital of Xiamen University ( Site 4060), Xiamen, Fujian
The First Affiliated Hospital ( Site 4043), Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital ( Site 4049), Nanning, Guangxi
Harbin Medical University Cancer Hospital ( Site 4033), Harbin, Heilongjiang
Hubei Cancer Hospital ( Site 4059), Wuhan, Hubei
Xiangya Hospital Central-South University ( Site 4035), Changsha, Hunan
Hunan Cancer Hospital ( Site 4050), Changsha, Hunan
Nanjing Drum Tower Hospital ( Site 4037), Nanjing, Jiangsu
Jiangxi Maternal and Child Health Hospital ( Site 4051), Nanchang, Jiangxi
The First Bethune Hospital of Jilin University ( Site 4057), Changchun, Jilin
The First Affiliated Hospital of Xi an Jiaotong University ( Site 4045), XI An, Shaanxi
Obstetrics and Gynecology Hosp. Fudan University ( Site 4041), Shanghai, Shanghai
Shanghai Renji Hospital Affiliated to Jiao Tong University ( Site 4053), Shanghai, Shanghai
Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 4001), Shanghai, Shanghai
Sichuan Cancer Hospital ( Site 4039), Chengdu, Sichuan
Tianjin Medical University Cancer Institute & Hospital ( Site 4054), Tianjin, Tianjin
Yunnan Province Cancer Hospital-Gynecology Department ( Site 4055), Kunming, Yunnan
The First Affiliated Hospital, Zhejiang University-Gynecology ( Site 4002), Hangzhou, Zhejiang
Women s Hospital School of Medicine Zhejiang University ( Site 4032), Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University ( Site 4056), Wenzhou, Zhejiang
Clínica Vida Fundación - Sede Poblado ( Site 1096), Medellin, Antioquia
Instituto Nacional de Cancerología E.S.E ( Site 1094), Bogota, Distrito Capital De Bogota
Instituto Cancerologico de Narino Ltda ( Site 1092), San Juan De Pasto, Narino
Fundacion Valle del Lili ( Site 1093), Cali, Valle Del Cauca
Fakultní nemocnice Brno Bohunice-Gynekologicko-porodnicka klinika ( Site 2394), Brno, Brno-mesto
Fakultni nemocnice Kralovske Vinohrady ( Site 2393), Praha, Praha 10
Vseobecna fakultni nemocnice v Praze ( Site 2391), Praha, Praha 2
Fakultni nemocnice Olomouc ( Site 2392), Olomouc, Not set
Rigshospitalet University Hospital ( Site 2515), Copehagen, Hovedstaden
Herlev Hospital ( Site 2514), Herlev, Hovedstaden
Aalborg Universitetshospital ( Site 2511), Aalborg, Nordjylland
Roskilde Sygehus ( Site 2513), Roskilde, Sjaelland
Odense Universitetshospital ( Site 2512), Odense, Syddanmark
Tampere University Hospital ( Site 2541), Tampere, Pirkanmaa
Kuopio University Hospital ( Site 2543), Kuopio, Pohjois-Savo
Turku University Hospital ( Site 2542), Turku, Varsinais-Suomi
Institut De Cancerologie De Lorraine ( Site 2072), Vandoeuvre les Nancy, Ain
Centre Antoine Lacassagne ( Site 2073), Nice, Alpes-Maritimes
Centre Francois Baclesse ( Site 2062), Caen, Calvados
Hôpital Privé Des Côtes d'Armor ( Site 2063), Plérin, Cotes-d Armor
CHU Besancon - Hopital Jean Minjoz ( Site 2068), Besancon, Doubs
Institut Bergonie ( Site 2067), Bordeaux, Gironde
Institut Universitaire du Cancer Toulouse - Oncopole ( Site 2065), Toulouse, Haute-Garonne
Institut Regional du Cancer de Montpellier - ICM ( Site 2069), Montpellier, Herault
Hopital Cochin ( Site 2070), Paris, Ile-de-France
Gustave Roussy ( Site 2071), Villejuif, Ile-de-France
Hopital prive du Confluent ( Site 2061), Nantes, Loire-Atlantique
Centre Hospitalier Lyon Sud ( Site 2064), Pierre Benite, Rhone
SLK-Kliniken Heilbronn GmbH ( Site 2116), Heilbronn, Baden-Wurttemberg
Klinikum Ludwigsburg ( Site 2111), Ludwigsburg, Baden-Wurttemberg
Universitaetsklinikum Tuebingen ( Site 2113), Tübingen, Baden-Wurttemberg
Medizinische Hochschule Hannover-Department of Obstetrics and Gynecology ( Site 2109), Hannover, Niedersachsen
Universitätsklinikum Bonn-Gynaecological oncology ( Site 2103), Bonn, Nordrhein-Westfalen
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 2105), Essen, Nordrhein-Westfalen
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur, Dresden, Sachsen
Universitätsklinikum Schleswig-Holstein ( Site 2101), Lübeck, Schleswig-Holstein
General Hospital of Patras. St Andrews ( Site 2421), Patras, Achaia
Geniko Panepistimako Nosokomeio ARETEIO ( Site 2423), Athens, Attiki
Perifereiako Geniko Nosokomeio ALEXANDRA ( Site 2425), Athens, Attiki
Athens University Hospital ATTIKON ( Site 2424), Chaidari, Attiki
Hospital Hygeia ( Site 2426), Marousi, Attiki
Euromedica General Clinic of Thessaloniki ( Site 2422), Thessaloniki, Not set
Rambam Medical Center ( Site 2307), Haifa, Not set
Edith Wolfson Medical Center ( Site 2306), Holon, Not set
Hadassah Medical Center. Ein Kerem ( Site 2303), Jerusalem, Not set
Rabin Medical Center ( Site 2305), Petah Tikva, Not set
Chaim Sheba Medical Center ( Site 2301), Ramat Gan, Not set
Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 2121), Roma, Abruzzo
Fondazione Policlinico Universitario Agostino Gemelli ( Site 2124), Roma, Lazio
Istituto di Candiolo - IRCCS ( Site 2125), Candiolo, Piemonte
Azienda Ospedaliera Spedali Civili di Brescia ( Site 2135), Brescia, Not set
IRCCS Ospedale San Raffaele ( Site 2130), Milano, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2122), Milano, Not set
Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 2132), Milano, Not set
Azienda Ospedaliera Universitaria Federico II ( Site 2123), Napoli, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2127), Napoli, Not set
Istituto Oncologico Veneto IRCCS-Oncologia 2 ( Site 2134), Padova, Not set
Aichi Cancer Center Hospital ( Site 4190), Nagoya, Aichi
National Cancer Center Hospital East ( Site 4197), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 4181), Matsuyama, Ehime
Ehime University Hospital ( Site 4187), Toon, Ehime
Kurume University Hospital ( Site 4186), Kurume, Fukuoka
Gunma Prefectural Cancer Center ( Site 4183), Ota, Gunma
Hokkaido University Hospital ( Site 4194), Sapporo, Hokkaido
Hyogo Cancer Center ( Site 4195), Akashi, Hyogo
Iwate Medical University Hospital ( Site 4189), Shiwa-gun, Iwate
University of the Ryukyus Hospital ( Site 4184), Nakagami-gun, Okinawa
Saitama Medical University International Medical Center ( Site 4182), Hidaka, Saitama
Shizuoka Cancer Center Hospital and Research Institute ( Site 4192), Sunto-gun, Shizuoka
National Hospital Organization Kyushu Cancer Center ( Site 4193), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 4185), Niigata, Not set
Osaka International Cancer Institute ( Site 4188), Osaka, Not set
The Cancer Institute Hospital of JFCR ( Site 4196), Tokyo, Not set
Keio University Hospital ( Site 4191), Tokyo, Not set
National Cancer Center ( Site 4065), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 4063), Seongnam-si, Kyonggi-do
Severance Hospital Yonsei University Health System ( Site 4062), Seoul, Not set
Asan Medical Center ( Site 4061), Seoul, Not set
Samsung Medical Center ( Site 4064), Seoul, Not set
Investigacion Onco Farmaceutica S de RL de CV ( Site 1127), La Paz, Baja California Sur
Hospital San Lucas Cardiologica del Sureste ( Site 1122), Tuxtla Gutierrez, Chiapas
Instituto Nacional de Cancerologia ( Site 1124), Cdmx, Distrito Federal
Christus Muguerza Clinica Vidriera ( Site 1125), Monterrey, Nuevo Leon
I Can Oncology Center SA de CV ( Site 1126), Monterrey, Nuevo Leon
Hospital Angeles Roma ( Site 1123), Ciudad de Mexico, Not set
Centro Oncologico Internacional. SEDNA ( Site 1121), Mexico City, Not set
University Hospital of North Norway ( Site 2153), Tromso, Troms
Soerlandet sykehus HF Kristiansand ( Site 2152), Kristiansand, Vest-Agder
Oslo Universitetssykehus Radiumhospitalet ( Site 2151), Oslo, Not set
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2487), Siedlce, Mazowieckie
Szpital Kliniczny im Ks Anny Mazowieckiej ( Site 2481), Warszawa, Mazowieckie
Bialostockie Centrum Onkologii ( Site 2483), Bialystok, Podlaskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2482), Gliwice, Slaskie
Swietokrzyskie Centrum Onkologii SPZOZ ( Site 2485), Kielce, Swietokrzyskie
SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2486), Olsztyn, Warminsko-mazurskie
Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 2484), Poznan, Wielkopolskie
Arkhangelsk Clinical Oncological Dispensary ( Site 2637), Arkhangelsk, Arkhangel Skaya Oblast
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 2645), Ufa, Baskortostan, Respublika
Chelyabinsk Regional Clinical Center Oncology and Nuclear Medicine ( Site 2644), Chelyabinsk, Chelyabinskaya Oblast
Krasnoyarsk Regional Clinical oncology dispensary ( Site 2643), Krasnoyarsk, Krasnoyarskiy Kray
National Research Ogarev Mordovia State University ( Site 2648), Saransk, Mordoviya, Respublika
FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 2634), Moscow, Moskva
Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2631), Moscow, Moskva
Nizhegorodsky Regional Oncology Dispensary-chemotherapy department (Branch№1) ( Site 2639), Nizhniy Novgorod, Nizhegorodskaya Oblast
Samara Regional Clinical Oncology Center-Chemotherapy Dapartment ( Site 2649), Samara, Samarskaya Oblast
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2636), Saint-Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2646), Kazan, Tatarstan, Respublika
Tomsk Scientific Research Institute of Oncology-Chemotherapy ( Site 2638), Tomsk, Tomskaya Oblast
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 2641), Yaroslavl, Yaroslavskaya Oblast
Hospital Josep Trueta ( Site 2184), Girona, Gerona
Clinica Universitaria de Navarra ( Site 2181), Madrid, Madrid, Comunidad De
Hospital Vall D Hebron ( Site 2182), Barcelona, Not set
Hospital Clinic i Provincial ( Site 2185), Barcelona, Not set
Hospital Universitario Reina Sofia ( Site 2183), Cordoba, Not set
Hospital Clinico San Carlos ( Site 2187), Madrid, Not set
Hospital Universitario La Paz ( Site 2186), Madrid, Not set
Universitetssjukhuset i Linkoping. ( Site 2222), Linkoping, Ostergotlands Lan
Karolinska Universitetssjukhuset Solna ( Site 2220), Solna, Stockholms Lan
Blod-och Tumorsjukdomar ( Site 2221), Uppsala, Uppsala Lan
Changhua Christian Hospital ( Site 4095), Changhua, Not set
Taichung Veterans General Hospital ( Site 4094), Taichung, Not set
MacKay Memorial Hospital ( Site 4092), Taipei, Not set
Taipei Veterans General Hospital ( Site 4093), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 4091), Taoyuan, Not set
Baskent Adana Dr Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2355), Adana, Not set
Cukurova Uni. Tip Fakultesi ( Site 2353), Adana, Not set
Baskent Universitesi Ankara Hastanesi ( Site 2354), Ankara, Not set
Ankara Universitesi Tıp Fakultesi Hastanesi ( Site 2350), Ankara, Not set
Medipol Universite Hastanesi ( Site 2352), Istanbul, Not set
Ege University Medical Faculty ( Site 2351), Izmir, Not set
I.E.U. Medical Point Hastanesi ( Site 2356), Izmir, Not set
Chernihiv Medical Center of Modern Oncology ( Site 2368), Chernihiv, Chernihivska Oblast
Municipal Enterprise "Bukovinian сlinical oncology сenter" ( Site 2366), Chernivtsi, Chernivetska Oblast
SO Grigoriev Institute for Medical Radiology and Oncology of NAMS of Ukraine ( Site 2363), Kharkiv, Kharkivska Oblast
MNE "Khmelnytskyi regional antitumor center" ( Site 2365), Khmelnitskyi, Khmelnytska Oblast
LISOD - Israeli Oncological Hospital MedX-ray International Group, LLC ( Site 2364), Kiev, Kyivska Oblast
Lviv State Regional Oncological Center ( Site 2361), Lviv, Lvivska Oblast
The Municipal Enterprise Volyn Regional Medical Oncology Centre ( Site 2362), Lutsk, Volynska Oblast
Bristol Haematology and Oncology Centre ( Site 2244), Bristol, Bristol, City Of
Castle Hill Hospital-Academic Oncology ( Site 2252), Cottingham, East Riding Of Yorkshire
Beatson West of Scotland Cancer Centre ( Site 2247), Glasgow, Glasgow City
UCLH NHS Foundation Trust ( Site 2242), London, London, City Of
Royal Marsden NHS Foundation Trust ( Site 2248), London, London, City Of
Royal Marsden Hospital Sutton-Surrey ( Site 2241), Sutton, London, City Of
Leicester Royal Infirmary. Univ. Hosp. of Leicester NHS Trust ( Site 2249), Leicester, Not set
The Christie Hospital NHS Foundation Trust ( Site 2243), Manchester, Not set
Conditions: Endometrial Neoplasms
Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer
Active Not Recruiting
This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together to treat patients with urothelial cancer. The study will compare these drugs to other drugs that are usually used to treat this cancer (standard of care). The patients in this study will have cancer that has spread from their urinary system to other parts of their body.
This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together to treat patients with urothelial cancer. The study will compare these drugs to other drugs that are usually used to treat this cancer (standard of care). The patients in this study will have cancer that has spread from their urinary system to other parts of their body. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: Ironwood Cancer & Research Centers - Chandler, Chandler, Arizona +259 locations
Ironwood Cancer & Research Centers - Chandler, Chandler, Arizona
Arizona Oncology Associates PD - HOPE, Tucson, Arizona
Providence St Joseph Medical Center, Burbank, California
City of Hope National Medical Center, Duarte, California
University of California Los Angeles Medical Center, Los Angeles, California
University of California Irvine - Newport, Orange, California
Rocky Mountain Cancer Centers - Aurora, Aurora, Colorado
University of Colorado Hospital / University of Colorado, Aurora, Colorado
Cancer Centers of Colorado - Denver, Denver, Colorado
Yale Cancer Center, New Haven, Connecticut
Eastern CT Hematology and Oncology Associates, Norwich, Connecticut
Lombardi Cancer Center / Georgetown University Medical Center, Washington, District of Columbia
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Winship Cancer Institute / Emory University School of Medicine, Atlanta, Georgia
Georgia Cancer Specialists / Northside Hospital Cancer Institute, Marietta, Georgia
Louisiana State University/ East Jefferson General Hospital, Metairie, Louisiana
Maine Health Cancer Care, Biddeford, Maine
Johns Hopkins Medical Center, Baltimore, Maryland
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
New Mexico Cancer Center, Albuquerque, New Mexico
New York University (NYU) Cancer Institute, New York, New York
Mount Sinai Medical Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Vidant Medical Center, Greenville, North Carolina
The Cleveland Clinic, Cleveland, Ohio
Toledo Clinic Cancer Center, Toledo, Ohio
Hillman Cancer Center / University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Saint Francis Hospital / Bon Secours - South Carolina, Greenville, South Carolina
West Cancer Center & Research Institute, Germantown, Tennessee
University of Texas Southwestern Medical Center, Dallas, Texas
UT Health East Texas Hope Cancer Center, Tyler, Texas
Huntsman Cancer Institute, Salt Lake City, Utah
University of Virginia, Charlottesville, Virginia
Seattle Cancer Care Alliance / University of Washington, Seattle, Washington
Site AR54008, Buenos Aire, Not set
Site AR54011, Caba, Not set
Site AR54005, Cordoba, Not set
Site AR54006, La Rioja, Not set
Site AR54004, Mendoza, Not set
Site AR54001, Rosario, Not set
Site AR54002, San Miguel, Not set
Site AR54012, Tucuman, Not set
Site AR54003, Viedma, Not set
Site AU61003, Box Hill, Not set
Site AUS61001, Douglas, Not set
Site AUS61004, Heidelberg, Not set
Site AUS61002, Macquarie Park, Not set
Site AUS61006, South Australia, Not set
Site AU61005, South Brisbane, Not set
Site BE32003, Brussels, Not set
Site BE32002, Ghent, Not set
Site BE32001, Liege, Not set
Site BE32007, Lueven, Not set
Site BE32006, Roeselare, Not set
Site CA11004, Calgary, Alberta
Site CA11003, Edmonton, Alberta
Site CA11006, Vancouver, British Columbia
Site CA11002, Hamilton, Ontario
Site CA11009, London, Ontario
Site CA11011, Oshawa, Ontario
Site CA11012, Toronto, Ontario
Site CA11005, Toronto, Ontario
Site CA11010, Montreal, Quebec
Site CA11001, Montreal, Quebec
Site CA11008, Quebec, Not set
Site CN86009, Beijing City, Not set
Site CN86001, Beijing, Not set
Site CN86004, Beijing, Not set
Site CN86005, Beijing, Not set
Site CN86015, Bengbu, Not set
Site CN86003, Changchun, Not set
Site CN86006, Changsha, Not set
Site CN86016, Changsha, Not set
Site CN86010, Chengdu, Not set
Site CN86024, Chongqing, Not set
Site CN86007, Chongqing, Not set
Site CN86028, Fuzhou, Not set
Site CN86002, Guangzhou, Not set
Site CN86020, Gunagzhou, Not set
Site CN86018, Hangzhou, Not set
Site CN86013, Hangzhou, Not set
Site CN86022, Hangzhou, Not set
Site CN86025, Hefei, Not set
Site CN86027, Jinan, Not set
Site CN86017, Nanjing, Not set
Site CN86012, Nanjing, Not set
Site CN86021, Ningbo, Not set
Site CN86014, Shanghai, Not set
Site CN86011, Shenyang City, Not set
Site CN86023, Tianjin, Not set
Site CN86019, Tianjin, Not set
Site CN86029, Wenzhou, Not set
Site CN86008, Wuhan City, Not set
Site CN86030, Xicheng District, Not set
Site CN86026, Xuzhou, Not set
Site CZ42006, Brno, Not set
Site CZ42001, Hradec Kralove, Not set
Site CZ42004, Olomouc, Not set
Site CZ42005, Praha 4-Krc, Not set
Site DK45001, Aalborg, Not set
Site DK45003, Aarhus N, Not set
Site FR33014, Bordeaux, Not set
Site FR33016, Lyon, Not set
Site FR33003, Nice Cedex 2, Not set
Site FR33020, Pierre-Bénite, Not set
Site FR33013, Strasbourg, Not set
Site FR33017, TOURS Cedex 09, Not set
Site FR33011, Villejuif-Cedex-France, Not set
Site DE49003, Berlin, Not set
Site DE49013, Bielefeld, Not set
Site DE49016, Düsseldorf, Not set
Site DE49014, Erlangen, Not set
Site DE49011, Essen, Not set
Site DE49007, Frankfurt am Main, Not set
Site DE49015, Gottingen, Not set
Site DE49005, Heidelberg, Not set
Site DE49009, Herne, Not set
Site DE49006, Jena, Not set
Site DE49001, Lubeck, Not set
Site DE49008, Magdeburg, Not set
Site DE49012, Mannheim, Not set
Site DE49002, Munchen, Not set
Site DE49004, Tübingen, Not set
Site DE49010, Ulm, Not set
Site HU36003, Budapest, Not set
Site HU36002, Budapest, Not set
Site HU36006, Debrecen, Not set
Site HU36001, Nyiregyhaza, Not set
Site HU36005, Szolnok, Not set
Site IL97203, Beer Sheva, Not set
Site IL97201, Haifa, Not set
Site IL97209, Holon, Not set
Site IL97206, Jerusalem, Not set
Site IL97202, Kfar Saba, Not set
Site IL97208, Petach Tikva, Not set
Site IL97211, Rehovot, Not set
Site IL97210, Tel Aviv, Not set
Site IL97204, Tel Hashomer, Not set
Site IL97205, Zerifin, Not set
Site IT39005, Areezo, Not set
Site IT39008, Candiolo, Not set
Site IT39009, Cremona, Not set
Site IT39006, Genova, Not set
Site IT39003, Meldola, Not set
Site IT39014, Milano, Not set
Site IT39007, Milano, Not set
Site IT39004, Pisa, Not set
Site IT39002, Terni, Not set
Site IT39011, Torrette, Not set
Site IT39001, Verona, Not set
Site JP81002, Bunkyo City, Not set
Site JP81009, Chiba, Not set
Site JP81018, Chiba, Not set
Site JP81013, Fukuoka, Not set
Site JP81020, Fukuoka, Not set
Site JP81011, Hirosaki, Not set
Site JP81006, Kawasaki-shi, Not set
Site JP81001, Koto-ku, Not set
Site JP81017, Kyoto, Not set
Site JP81015, Niigata, Not set
Site JP81005, Okayama, Not set
Site JP81016, Osakasayama-Shi, Not set
Site JP81008, Osaka, Not set
Site JP81007, Sapporo, Not set
Site JP81012, Sendai-city, Not set
Site JP81014, Tokushima, Not set
Site JP81019, Tokyo, Not set
Site JP81003, Toyama, Not set
Site JP81004, Tsukuba, Not set
Site JP81010, Ube, Not set
Site KR82001, Daejeon, Not set
Site KR82002, Goyang-si, Not set
Site KR82008, Hwasun, Not set
Site KR82004, Seongnam-si, Not set
Site KR82003, Seoul, Not set
Site KR82005, Seoul, Not set
Site KR82007, Seoul, Not set
Site KR82006, Seoul, Not set
Site NL31005, Amsterdam, Noord-Holland, Not set
Site NL31002, Amsterdam, Not set
Site NL31001, Amsterdam, Not set
Site NL31007, Leeuwarden, Not set
Site NL31004, Nieuwegein, Not set
Site NL31003, Rotterdam, Not set
Site NL31006, Utrecht, Not set
Site PL48002, Warszawa, Not set
Site RU70016, Arkhangelsk, Not set
Site RU70013, Barnaul, Not set
Site RU70020, Ivanovo, Not set
Site RU70014, Krasnoyarsk, Not set
Site RU70006, Leningradskaya Oblast', Not set
Site RU70004, Moscow, Not set
Site RU70011, Moscow, Not set
Site RU70003, Moscow, Not set
Site RU70017, Nizhniy Novgorod, Not set
Site RU70002, Omsk, Not set
Site RU70019, Pyatigorsk, Not set
Site RU70010, Saint Petersburg, Not set
Site RU70007, Saint Petersburg, Not set
Site RU70012, Saint-Petersburg, Not set
Site RU70009, Saransk, Not set
Site RU70008, St. Petersburg, Not set
Site RU70015, Tyumen, Not set
Site RU70005, Ufa, Not set
Site SG65001, Singapore, Not set
Site SG65002, Singapore, Not set
Site SG65003, Singapore, Not set
Site ES34017, Barcelona, Not set
Site ES34010, Barcelona, Not set
Site ES34006, Barcelona, Not set
Site ES34001, Barcelona, Not set
Site ES34008, Barcelona, Not set
Site ES34013, Cordoba, Not set
Site ES34021, Lugo, Not set
Site ES34018, Madrid, Not set
Site ES34002, Madrid, Not set
Site ES34003, Madrid, Not set
Site ES34015, Madrid, Not set
Site ES34004, Manresa, Not set
Site ES34020, Pamplona, Not set
Site ES34016, Sabadell, Not set
Site ES34012, Santander, Not set
Site ES34007, Sevilla, Not set
Site ES34019, Valencia, Not set
Site ES34009, Valencia, Not set
Site CH41004, Basel, Not set
Site CH41002, Bern, Not set
Site CH41001, Chur, Not set
Site CH41003, Winterthur, Not set
Site TW88603, Kaohsiung, Not set
Site TW88602, Kweishan, Not set
Site TW88607, Taichung, Not set
Site TW88606, Taichung, Not set
Site TW88604, Tainan, Not set
Site TW88605, Taipei, Not set
Site TW88601, Taipei, Not set
Site TH66004, Bangkok, Not set
Site TH66003, Bangkok, Not set
Site TH66005, Chiang Mai, Not set
Site TH66002, HatYai, Not set
Site TH66006, Krung Thep Maha Nakhon, Not set
Site TH66007, Muang, Not set
Site TH66001, Ratchathewi, Not set
Site TR90007, Ankara, Not set
Site TR90009, Ankara, Not set
Site TR90005, Antalya, Not set
Site TR90004, Edirne, Not set
Site TR90008, Istanbul, Not set
Site TR90003, Istanbul, Not set
Site TR90002, Istanbul, Not set
Site TR90001, Konya, Not set
Site TR90006, Malatya, Not set
Site UK44005, Glasgow, Not set
Site UK44001, London, Not set
Site UK44009, London, Not set
Site UK44006, Oxford, Not set
Site UK44010, Plymouth, Not set
Site UK44002, Preston, Not set
Site UK44003, Sheffield, Not set
Site UK44008, Southampton, Not set
Conditions: Urothelial Cancer
A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer
Active Not Recruiting
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC).
Eligible participants will be randomized in a 1:1 ratio to receive one of t... Read More
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC).
Eligible participants will be randomized in a 1:1 ratio to receive one of the following treatment regimens during the induction phase:
* Arm A: Tiragolumab plus atezolizumab plus pemetrexed and carboplatin or cisplatin
* Arm B: Placebo plus pembrolizumab plus pemetrexed and carboplatin or cisplatin
Following the induction phase, participants will continue maintenance therapy with either tiragolumab in combination with atezolizumab and pemetrexed (Arm A) or placebo in combination with pembrolizumab and pemetrexed (Arm B). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: UCLA, Los Angeles, California +121 locations
UCLA, Los Angeles, California
Torrance Memorial Physician Network/Cancer Care, Torrance, California
PIH Health Whittier Hospital, Whittier, California
SCRI Florida Cancer Specialists South, Fort Myers, Florida
SCRI Florida Cancer Specialists North, Saint Petersburg, Florida
Advent Health Orlando, Winter Park, Florida
Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia
Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne, Indiana
Baptist Health Lexington, Lexington, Kentucky
Tennessee Oncology Chattanooga, Chattanooga, Tennessee
Sarah Cannon Research Institute / Tennessee Oncology, Nashville, Tennessee
Inova Schar Cancer Institute, Fairfax, Virginia
AZORG Campus Aalst-Moorselbaan, Aalst, Not set
Cliniques Universitaires St-Luc, Bruxelles, Not set
CHU UCL Mont-Godinne, Mont-godinne, Not set
Vitaz, Sint Niklaas, Not set
Crio - Centro Regional Integrado de Oncologia, Fortaleza, Ceará
Oncocentro Belo Horizonte, Belo Horizonte, Minas Gerais
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, Rio Grande Do Sul
Hospital das Clinicas - UFRGS, Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceicao, Porto Alegre, Rio Grande Do Sul
Hospital de Cancer de Barretos, Barretos, São Paulo
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, São Paulo
Cross Cancer Institute, Edmonton, Alberta
Royal Victoria Regional Health Centre, Barrie, Ontario
Lakeridge Health Oshawa, Oshawa, Ontario
Sault Area Hospital, Sault Ste. Marie, Ontario
Beijing Cancer Hospital, Beijing, Not set
Jilin Cancer Hospital, Changchun, Not set
Xiangya Hospital Central South University, Changsha City, Not set
Changzhou First People's Hospital, Changzhou, Not set
Affiliated Hospital of Chengde Medical University, Chengde City, Not set
Sichuan Cancer Hospital, Chengdu City, Not set
West China Hospital - Sichuan University, Chengdu City, Not set
Anhui Provincial Hospital, Hefei, Not set
Jinan Central Hospital, Jinan City, Not set
Pingxiang People Hospital, Pingxiang City, Not set
Qingdao Central Hospital, Qingdao City, Not set
Weifang People's Hospital, Weifang City, Not set
Hubei Cancer Hospital, Wuhan, Not set
The First Affiliated Hospital of Xian Jiao Tong University, Xi'an City, Not set
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang City, Not set
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Not set
Rigshospitalet, København Ø, Not set
Odense Universitetshospital, Onkologisk Afdeling R, Odense C, Not set
Sjællands Universitetshospital, Roskilde, Roskilde, Not set
Institut Bergonie, Bordeaux, Not set
Hopital Nord, Marseille cedex 20, Not set
Hopital de Pontchaillou, Rennes, Not set
CHU Strasbourg - Nouvel Hopital Civil, Strasbourg, Not set
CHU de Toulouse - Hôpital Larrey, Toulouse cedex 9, Not set
Helios Klinikum Emil von Behring GmbH, Berlin, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
St. Vincentius Kliniken Karlsruhe, Karlsruhe, Not set
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Medizinische Klinik, Pneumologie, Mainz, Not set
Klinikum der Philipps-Universität Marburg, Marburg, Not set
Hong Kong United Oncology Centre, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Tuen Mun Hospital, Hong Kong, Not set
Prince of Wales Hospital, Shatin, Not set
Centro Di Riferimento Oncologico, Aviano, Friuli-Venezia Giulia
A.O. Villa Scassi, Genova, Liguria
Azienda Ospedaliero-Universitaria Careggi, Firenze, Toscana
Kurume University Hospital, Fukuoka, Not set
Hiroshima University Hospital, Hiroshima, Not set
Takarazuka City Hospital, Hyogo, Not set
University Hospital Kyoto Prefectural University of Medicine, Kyoto, Not set
Sendai Kousei Hospital, Miyagi, Not set
Osaka International Cancer Institute, Osaka, Not set
Kansai Medical University Hospital, Osaka, Not set
Kindai University Hospital, Osaka, Not set
NHO Kinki Chuo Chest Medical Center, Osaka, Not set
Saitama Cancer Center, Saitama, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Kosin University Gospel Hospital, Busan, Not set
Chungnam National University Hospital, Daejeon, Not set
St. Vincent's Hospital, Gyeonggi-do, Not set
Samsung Changwon Hospital, Gyeongsangnam-do, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Seoul St Mary's Hospital, Seoul, Not set
Health Pharma Professional Research, Cdmx, Mexico CITY (federal District)
Cuidados oncologicos, Querétaro, Queretaro
ARKE Estudios Clínicos S.A. de C.V., Ciudad de México, Not set
Auckland City Hospital, Cancer and Blood Research, Auckland, Not set
Waikato Hospital - Cancer and Blood Research Trials Unit, Hamilton, Not set
Palmerston North Hospital, Palmerston North, Not set
Tauranga Hospital, Clinical Trials Unit, Tauranga, Not set
Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna, Lodz, Not set
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn, Not set
ICO L'Hospitalet, L Hospitalet De Llobregat, Barcelona
Hospital Son Llatzer, Palma de Mallorca, Islas Baleares
Complejo Hospitalario Universitario Insular?Materno Infantil, Las Palmas de Gran Canaria, LAS Palmas
Hospital del Mar, Barcelona, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruna, Not set
Hospital Lucus Augusti, Lugo, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Univ. Nuestra Señora de Valme, Sevilla, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Kantonsspital Aarau, Aarau, Not set
Kantonsspital Graubünden Medizin Onkologie, Chur, Not set
UniversitätsSpital Zürich, Zürich, Not set
Changhua Christian Hospital, Chang Hua, Not set
China Medical University Hospital, Taichung, Not set
Taipei Veterans General Hospital, Taipei City, Not set
Chulalongkorn Hospital, Bangkok, Not set
Faculty of Med. Siriraj Hosp., Bangkok, Not set
Maharaj Nakorn Chiang Mai Hospital, ChiangMai, Not set
Songklanagarind Hospital, Songkhla, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Dicle University Faculty of Medicine, Diyarbakir, Not set
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set
Medeniyet University Goztepe Training and Research Hospital., Kadiköy, Not set
Castle Hill Hospital, Hull, Not set
Barts & London School of Med, London, Not set
Guy'S Hospital, London, Not set
Christie Hospital Nhs Trust, Manchester, Not set
Nottingham City Hospital, Nottingham, Not set
Conditions: Non-small Cell Lung Cancer (NSCLC)
BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma
Completed
The aim of this clinical trial is to assess the effect of treatment with a monoclonal antibody called atezolizumab in patients diagnosed with a type of lung cancer called malignant pleural mesothelioma. The efficacy (whether the treatment works), safety and tolerability (side effects of treatment) of atezolizumab plus bevacizumab in combination with standard chemotherapy versus bevacizumab in combination with standard chemotherapy will be investigated.
The aim of this clinical trial is to assess the effect of treatment with a monoclonal antibody called atezolizumab in patients diagnosed with a type of lung cancer called malignant pleural mesothelioma. The efficacy (whether the treatment works), safety and tolerability (side effects of treatment) of atezolizumab plus bevacizumab in combination with standard chemotherapy versus bevacizumab in combination with standard chemotherapy will be investigated. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: University Hospital Leuven, Leuven, Not set +41 locations
University Hospital Leuven, Leuven, Not set
CHU Liege, Liege, Not set
Unicancer - Institut Bergonie, Bordeaux, Not set
Caen- CHU, Caen, Not set
Le Mans - CHG, Le Mans, Not set
Lyon - Centre Léon Bérard, Lyon, Not set
Hospital Nord, Marseille, Not set
Curie Cancer Center Paris, Paris, Not set
Toulouse - CHU, Toulouse, Not set
Tours - CHU, Tours, Not set
SS Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Not set
IRCCS Instituto Tumori Giovanni Paolo II, Bari, Not set
Fondazione IRCCS Istituto Nazionale die Tumori, Milan, Not set
Instituto Europeo di Oncologia (IEO), Milan, Not set
AULSS2 Marca Trevigiana Treviso, Treviso, Not set
University Hospital of Turin, Turin, Not set
Alicante University Hospital ISABIAL, Alicante, Not set
ICO Hospitalet, Barcelona, Not set
Vall Hebron University Hospital/Vall Hebron Institue Oncology, Barcelona, Not set
Puerta de Hierro Hospital, Majadahonda, Not set
Hospital Parc Tauli Sabadell, Sabadell, Not set
Virgen del Rocio, Seville, Not set
Complexo Hospitalario Universitario de Vigo, Vigo, Not set
Kantonsspital Aarau, Aarau, Not set
Istituto Oncologica della Svizzera Italiana, Bellinzona, Not set
Ferdinando Cerciello, Bern, Not set
Kantonsspital Graubünden, Chur, Not set
CHUV, Lausanne, Not set
Luzerner Kantonsspital, Lucerne, Not set
Kantonsspital St. Gallen, Saint Gallen, Not set
Kantonsspital Winterthur, Winterthur, Not set
UniversitätSpital Zürich, Zürich, Not set
Addenbrooke's Hospital, Cambridge, Not set
Clatterbridge Cancer Centre, Liverpool, Not set
Guy's and St Thomas' Hospital, London, Not set
Royal Marsden Hospital (Fulham Road), London, Not set
Royal Marsden Hospital (Sutton), London, Not set
Kent Oncology Centre, Maidstone, Not set
Wythenshawe Hospital, Manchester, Not set
Plymouth Hospitals NHS Trust, Plymouth, Not set
Weston Park Hospital, Sheffield, Not set
Royal Cornwall Hospital, Truro, Not set
Conditions: Pleural Mesothelioma Malignant Advanced
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