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Cisplatin Treatment Options in United Kingdom
A collection of 298 research studies where Cisplatin is the interventional treatment. These studies are located in the United Kingdom . Cisplatin is used for conditions such as Head and Neck Cancer, Lung Cancer and Non-Small Cell Lung Cancer.
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Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)
Active Not Recruiting
A Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants with MIBC and in participants with locally advanced or metastatic Urothelial Carcinoma (UC) who have progressed during or following a platinum-containing regimen. The study is designed with the flexibility to open new treatment arms as new treatments become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, or modify the participant population (e.g., with... Read More
A Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants with MIBC and in participants with locally advanced or metastatic Urothelial Carcinoma (UC) who have progressed during or following a platinum-containing regimen. The study is designed with the flexibility to open new treatment arms as new treatments become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, or modify the participant population (e.g., with regard to prior anti-cancer treatment or biomarker status). Participants in the mUC Cohort who experience loss of clinical benefit or unacceptable toxicity during Stage 1 may be eligible to continue treatment with a different treatment regimen for Stage 2. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: UCLA Department of Medicine, Los Angeles, California +33 locations
UCLA Department of Medicine, Los Angeles, California
UCSF Comprehensive Cancer Ctr, San Francisco, California
Stanford Cancer Center, Stanford, California
University of Kentucky Chandler Medical Center, Lexington, Kentucky
Norton Cancer Institute, Louisville, Kentucky
Memorial Sloan-Kettering Cancer Center, Commack, New York
Levine Cancer Institute, Charlotte, North Carolina
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Cleveland Clinic, Cleveland, Ohio
The University of Texas MD Anderson Cancer Center, Houston, Texas
Centre Francois Baclesse, Caen, Not set
Centre Leon Berard, Lyon, Not set
Institut régional du Cancer Montpellier, Montpellier, Not set
Institut Claudius Regaud, Toulouse, Not set
Attiko Hospital University of Athens, Athens, Not set
Athens Medical Center, Athens, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Severance Hospital, Seoul, Not set
ICO I Hospitalet Hospital Duran i Reynals Instituto Catalan de Oncologia de Hospitalet ICO, L?Hospitalet De Llobregat, Barcelona
Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, LA Coruna
Clinica Universitaria de Navarra, Pamplona, Navarra
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set
Hospital Clinic i Provincial, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital General Universitario Gregorio Mara, Madrid, Not set
MD Anderson Cancer Center, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz., Madrid, Not set
Hospital Univ 12 de Octubre, Madrid, Not set
START Madrid. Centro Integral Oncologico Clara Campal, Madrid, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Not set
Barts and The London, London, Not set
Royal Marsden NHS Foundation Trust, Sutton, Not set
Conditions: Urothelial Carcinoma, Bladder Cancer
Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]
Active Not Recruiting
This is a Phase III, global, multicenter, open-label, randomized study to compare the efficacy and safety of 16 cycles (1 cycle duration=21 days) of atezolizumab (MPDL3280A) treatment compared with best supportive care (BSC) in participants with Stage IB-Stage IIIA non-small cell lung cancer (NSCLC) following resection and adjuvant chemotherapy, as measured by disease-free survival (DFS) as assessed by the investigator and overall survival (OS). Participants, after completing up to 4 cycles of a... Read More
This is a Phase III, global, multicenter, open-label, randomized study to compare the efficacy and safety of 16 cycles (1 cycle duration=21 days) of atezolizumab (MPDL3280A) treatment compared with best supportive care (BSC) in participants with Stage IB-Stage IIIA non-small cell lung cancer (NSCLC) following resection and adjuvant chemotherapy, as measured by disease-free survival (DFS) as assessed by the investigator and overall survival (OS). Participants, after completing up to 4 cycles of adjuvant cisplatin-based chemotherapy, will be randomized in a 1:1 ratio to receive atezolizumab for 16 cycles or BSC. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Highlands Oncology Group, Fayetteville, Arkansas +151 locations
Highlands Oncology Group, Fayetteville, Arkansas
California Cancer Associates for Research & Excellence, Inc., Encinitas, California
Compassionate Cancer Care Medical Group, Inc, Fountain Valley, California
University of California Los Angeles, Los Angeles, California
Kaiser Permanente, Vallejo, California
Kaiser Permanente - Walnut Creek, Walnut Creek, California
Eastern Connecticut Hematology and Oncology Associates, Norwich, Connecticut
Lynn Cancer Institute - West, Boca Raton, Florida
University of Miami School of Medicine - Sylvester at Deerfield, Deerfield Beach, Florida
SCRI Florida Cancer Specialists North, Saint Petersburg, Florida
Lewis Hall Singletary Oncology Center, Thomasville, Georgia
University of Illinois at Chicago, Chicago, Illinois
Illinois Cancer Care, Peoria, Illinois
Norton Cancer Institute, Louisville, Kentucky
St. Luke's Cancer Institute, Kansas City, Missouri
Hematology Oncology Associates of Northern New Jersey, Florham Park, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Valley Hospital, Paramus, New Jersey
Overlook Medical Center, Summit, New Jersey
Clinical Research Alliance, Lake Success, New York
Weill Cornell Medical College, New York, New York
Presbyterian Hospital, Charlotte, North Carolina
University of Cincinnati, Cincinnati, Ohio
Oncology Hematology Care - SCRI, Cincinnati, Ohio
Oregon Health and Science University, Portland, Oregon
University Oncology Associates, Chattanooga, Tennessee
Houston Methodist Cancer Center, Houston, Texas
Wellmont Medical Associates, Bristol, Virginia
Hematology Oncology Associates of Fredericksburg, Inc., Fredericksburg, Virginia
MultiCare Regional Cancer Center - Auburn, Auburn, Washington
Providence Everett Med Ctr, Everett, Washington
Swedish Medical Center, Seattle, Washington
Townsville Hospital, Douglas, Queensland
Cabrini Hospital Malvern, Malvern, Victoria
Cliniques Universitaires St-Luc, Bruxelles, Not set
Cancer Institute and Hospital Chinese Academy of Medical Sciences, Beijing, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Anhui Province Cancer Hospital, Hefei, Not set
Shanghai Chest Hospital, Shanghai, Not set
Shanghai Pulmonary Hospital, Shanghai, Not set
Liaoning Provincial Cancer Hospital, Shengyang, Not set
First Hospital of China Medical University, Shenyang, Not set
First Affiliated Hospital of Soochow University, Suzhou, Not set
Centre Hospitalier de Mont de Marsan - Hopital Layne, Mont de Marsan, Not set
Clinique Clémentville, Montpellier, Not set
Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque, Montpellier, Not set
Centre René Gauducheau Centre de Lutte Contre Le Cancer Nantes Atlantique, Nantes, Not set
Centre Hospitalier Regional Sud Reunion, Saint Pierre, Not set
Centre Hospitalier de Saint-Quentin, Saint-Quentin, Not set
Hopital d Instruction des Armees de Sainte Anne, Toulon, Not set
Evang. Lungenklinik Berlin Klinik für Pneumologie, Berlin, Not set
Ev.Krankenhaus Bielefeld gGmbH, Bielefeld, Not set
Stadtisches Klinikum Braunschweig, Braunschweig, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
Krankenhaus Nordwest, Frankfurt am Main, Not set
LungenClinic Grosshansdorf GmbH, Großhansdorf, Not set
Lungenklinik Hemer, Hemer, Not set
Universität Des Saarlandes, Homburg, Not set
Fachklinik für Lungenerkrankungen, Immenhausen, Not set
Vincentius-Diakonissen-Kliniken gAG, Karlsruhe, Not set
Katholisches Klinikum Marienhof, Koblenz Am Rhein, Not set
Klinikum Bogenhausen, München, Not set
Gemeinschaftspraxis für Hämatologie und Onkologie, Münster, Not set
Pius-Hospital Oldenburg, Oldenburg, Not set
Krankenhaus Barmherzige Bruder Regensburg, Regensburg, Not set
Prince of Wales Hosp, Shatin, Not set
University of Pecs, I st Dept of Internal Medicine, Pecs, Not set
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rend.Int., Szolnok, Not set
Rambam Medical Center, Haifa, Not set
Edith Wolfson Medical Center, Holon, Not set
Meir Medical Center, Kfar Saba, Not set
Chaim Sheba Medical Center, Tel Hashomer, Not set
Tel Aviv Sourasky Medical Ctr, Tel-Aviv, Not set
Ospedale Clinicizzato SS Annunziata, Chieti, Abruzzo
Azienda per l'Assistenza Sanitaria N° 5 - Friuli Occidentale, Pordenone, Friuli-Venezia Giulia
Policlinico Universitario Campus Biomedico Di Roma, Roma, Lazio
Asst Papa Giovanni XXIII, Bergamo, Lombardia
ASST Spedali Civili di Brescia, Brescia, Lombardia
Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano, Piemonte
Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Piemonte
Azienda Ospedaliera Di Rilievo Nazionale E Di Alta Specializzazione Garibaldi, Catania, Sicilia
Azienda Ospedaliero Universitaria Pisana, Pisa, Toscana
Ospedale Santa Chiara, Trento, Trentino-Alto Adige
Ospedale Silvestrini, Perugia, Umbria
Azienda Ospedaliera Universitaria Integrata Verona, Verona, Veneto
Aichi Cancer Center Hospital, Aichi, Not set
Hyogo Cancer Center, Akashi, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Bunkyo-ku, Not set
National Cancer Center Hospital, Chuo, Not set
Kyushu University Hospital, Fukuoka, Not set
Hiroshima University Hospital, Hiroshima, Not set
Saitama Cancer Center, Kitaadachi-gun, Not set
Hospital of the University of Occupational and Environmental Health,Japan, Kitakyushu-shi, Not set
Kumamoto University Hospital, Kumamoto-shi, Not set
Kyoto University Hospital, Kyoto, Not set
Shikoku Cancer Center, Matsuyama-shi, Not set
Kyorin University Hospital, Mitaka-shi, Not set
Niigata Cancer Center Hospital, Niigata-shi, Not set
Okayama University Hospital, Okayama, Not set
National Hospital Organization Hokkaido Cancer Center, Sapporo-shi, Not set
Toranomon Hospital, Tokyo, Not set
Tokyo Medical University Hospital, Tokyo, Not set
Kanagawa Cancer Center, Yokohama-shi, Asahi-ku, Not set
Chonnam National University Hwasun Hospital, Jeonnam, Not set
The Catholic University of Korea St. Vincent's Hospital, Suwon-si,, Not set
Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, Noord-Brabant
St. Antonius Ziekenhuis Nieuwegein, Nieuwegein, Not set
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy, Otwock, Not set
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu, Poznan, Not set
Centro Hospitalar E Universitário de Coimbra EPE, Coimbra, Not set
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe, Porto, Not set
Hospital de Sao Joao, Porto, Not set
Oncology Center Sf. Nectarie, Craiova, Not set
Principal Military Clinical Hospital n.a. N.N. Burdenko, Moscow, Moskovskaja Oblast
GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology), Saint Petersburg, Sankt Petersburg
Leningrad Regional Clinical Hospital, St. Petersburg, Sankt Petersburg
Scientific Research Institute of Oncology n.a. N.N. Petrov, St. Petersburg, Sankt Petersburg
City Clinical Hospital #1, Novosibirsk, Not set
Volgograd Regional Clinical Oncology Dispensary, Volgograd, Not set
Regional Clinical Oncology Hospital, Yaroslavl, Not set
Hospital Universitario Marques de Valdecilla, Santander, Cantabria
Consorcio Hospitalario Provincial de Castellon, Castellon de la Plana, Castellon
Hospital Universitario Virgen de La Arrixaca, El Palmar, Murcia
Hospital Universitario de Canarias, San Cristóbal De La Laguna, Tenerife
Hospital del Mar, Barcelona, Not set
Hospital Santa Creu i Sant Pau, Barcelona, Not set
Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set
C.H. Regional Reina Sofia, Cordoba, Not set
Complejo Hospitalario de Jaen, Jaen, Not set
Hospital Lucus Augusti, Lugo, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario HM Sanchinarro-CIOCC, Madrid, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Hosp Clinico Univ Lozano Blesa, Zaragoza, Not set
Changhua Christian Hospital, Changhua, Not set
Chang Gung Memorial Hospital Chiayi, Putzui City, Not set
Taichung Veterans General Hospital, Taichung, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Medical Foundation Linkou Branch, Taoyuan City, Not set
MI Dnipropetrovsk City Multifield Clinical Hospital 4 of Dnipropetrovsk Regional Council, Dnipropetrovsk, Katerynoslav Governorate
Communal Non profit Enterprise Regional Center of Oncology, Kharkiv, Kharkiv Governorate
Municipal Institution Odesa Regional Oncology Dispensary, Odesa, KIEV Governorate
Municipal Institution SubCarpathian ClinicalOncological Centre, Ivano-Frankivsk, Poltava Governorate
Communal Nonprofit Enterprise Podilsky Regional Center Of Oncology OfTheVinnytsia Regional Council, Vinnytsia, Vinnyts'ka Oblast
CE Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council, Kryvyi Rih, Not set
Kyiv City Clinical Oncological Center, Kyiv, Not set
Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary, Sumy, Not set
MI Zaporizhzhia Regional Clinical Oncological Dispensary Zaporizhzhia SMU Ch of Oncology, Zaporizhzhya, Not set
Colchester General Hospital, Colchester, Essex, Not set
St Bartholomew's Hospital, London, Not set
Conditions: Non-Small Cell Lung Cancer
Evaluation of Programmed Death Ligand 1 (PDL1) Response to Treatment in Extracellular Vesicles (EVs), Patient-derived Organoid (PDOs)s and Immune-marker Positron Emission Tomography (PET) Scanning in Non-small Cell Lung Cancer (NSCLC)
Not Yet Recruiting
The goal of this clinical trial is to investigate the utility of biomarker tools Extracellular Vesicles (EVs), Patient-derived organoid (PDOs), and PDL1 PET imaging for predicting how participants with recurrent NSCLC respond to standard of care treatment in the advanced/metastatic stages.
The goal of this clinical trial is to investigate the utility of biomarker tools Extracellular Vesicles (EVs), Patient-derived organoid (PDOs), and PDL1 PET imaging for predicting how participants with recurrent NSCLC respond to standard of care treatment in the advanced/metastatic stages. Read Less
Gender:
ALL
Ages:
30 years and above
Trial Updated:
07/01/2025
Locations: GSK Investigational Site, London, Not set
GSK Investigational Site, London, Not set
Conditions: Lung Cancer, Non-Small Cell
Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304)
Active Not Recruiting
The purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat, pembrolizumab monotherapy, and the EXTREME regimen (cetuximab + cisplatin or carboplatin + 5-fluorouracil) as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).
The purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat, pembrolizumab monotherapy, and the EXTREME regimen (cetuximab + cisplatin or carboplatin + 5-fluorouracil) as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: Pacific Cancer Medical Center, Anaheim, California +72 locations
Pacific Cancer Medical Center, Anaheim, California
UC Davis Comprehensive Cancer Center, Sacramento, California
St. Joseph Heritage Healthcare, Santa Rosa, California
University of Colorado Cancer Center, Aurora, Colorado
Yale Cancer Center, New Haven, Connecticut
Northwest Georgia Oncology Centers PC, Douglasville, Georgia
U of Kansas Cancer Center, Westwood, Kansas
Baptist Health, Louisville, Kentucky
St. Vincent Healthcare Cancer Ctr, Billings, Montana
New Mexico Cancer Care Alliance, Albuquerque, New Mexico
Oklahoma Cancer Specialists and Research, Tulsa, Oklahoma
Providence Portland Med Center, Portland, Oregon
Huntsman Cancer Institute Univ of Utah, Salt Lake City, Utah
Viginia Mason Med Ctr, Seattle, Washington
Chris OBrien Lifehouse, Camperdown, New South Wales
Macquarie University Hospital, North Ryde, New South Wales
Royal Brisbane & Women s Hospital, Herston, Queensland
Landeskrankenhaus Salzburg, Salzburg, Not set
Allgemeines Krankenhaus der Stadt Wien, Wien, Not set
Juravinski Cancer Center Hamilton Health Sciences, Hamilton, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Jewish General Hospital, Montreal, Quebec
CHU de Quebec-Universite Laval-Hotel Dieu de Quebec, Quebec, Not set
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz, Miskolc, Not set
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet, Szolnok, Not set
Istituto Europeo di Oncologia, Milano, Not set
IRRCS Instituto Clinico Humanitas, Rozzano, Not set
National Cancer Center Hospital East, Kashiwa, Chiba
Kanazawa University Hospital, Kanazawa, Ishikawa
Kanagawa Cancer Center, Yokohama, Kanagawa
Miyagi Cancer Center, Natori, Miyagi
Tohoku University Hospital, Sendai, Miyagi
Hyogo Cancer Center, Akashi, Not set
Kyushu University Hospital, Fukuoka, Not set
Hiroshima University Hospital, Hiroshima, Not set
Hokkaido University Hospital, Hokkaido, Not set
Kobe City Medical Center General Hospital, Kobe, Not set
Kindai University Hospital, Osakasayama City, Not set
Saitama Cancer Center, Saitama, Not set
Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Mazowiecki Szpital Onkologiczny, Wieliszew, Mazowieckie
Przychodnia Lekarska Komed, Konin, Not set
Zachodniopomorskie Centrum Onkologii, Szczecin, Not set
Inst. Portugues de Oncologia de Coimbra Frencisco Gentil EPE, Coimbra, Not set
Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE, Lisboa, Not set
Centro Hospitalar Lisboa Norte EPE - Hospital de Santa Maria, Lisboa, Not set
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE, Porto, Not set
Hospital Germans Trias i Pujol. ICO de Badalona, Badalona, Not set
Hospital General Universitari Vall d Hebron, Barcelona, Not set
Hospital Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Infanta Cristina, Madrid, Not set
Hospital de Nuestra Senora de Valme, Sevilla, Not set
Hospital Clinico Lozano Blesa, Zaragoza, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Chang Gung Medical Foundation. Linkou, Taoyuan, Not set
Adana Sehir Hastanesi, Adana, Not set
Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara, Not set
Trakya Universitesi Tip Fakultesi, Edirne, Not set
Istanbul Universitesi Onkoloji Enstitusu, Istanbul, Not set
Medipol Hastanesi, Istanbul, Not set
Ege Universitesi Tip Fakultesi Hastanesi, Izmir, Not set
Inonu Universitesi Turgut Ozal Tip Merkezi, Malatya, Not set
North Middlesex Hospital, London, Not set
University College London Hospitals (UCLH), London, Not set
The Royal Marsden Foundation Trust, London, Not set
The Royal Marsden Nhs Foundation Trust - Chelsea, London, Not set
Musgrove Park Hospital, Taunton, Not set
Conditions: Head and Neck Cancer
Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations
Active Not Recruiting
This is a Phase III, randomized, open-label, multicenter, global study to compare the efficacy and safety of Datopotamab Deruxtecan (Dato-DXd) in combination with durvalumab and carboplatin compared with pembrolizumab in combination with histology-specific platinum-based chemotherapy as first-line treatment of adults with stage IIIB, IIIC, or IV NSCLC without actionable genomic alterations (including sensitizing EGFR mutations, and ALK and ROS1 rearrangements).
This is a Phase III, randomized, open-label, multicenter, global study to compare the efficacy and safety of Datopotamab Deruxtecan (Dato-DXd) in combination with durvalumab and carboplatin compared with pembrolizumab in combination with histology-specific platinum-based chemotherapy as first-line treatment of adults with stage IIIB, IIIC, or IV NSCLC without actionable genomic alterations (including sensitizing EGFR mutations, and ALK and ROS1 rearrangements). Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
07/01/2025
Locations: Research Site, Phoenix, Arizona +255 locations
Research Site, Phoenix, Arizona
Research Site, Tucson, Arizona
Research Site, Hot Springs National Park, Arkansas
Research Site, Little Rock, Arkansas
Research Site, Springdale, Arkansas
Research Site, Fountain Valley, California
Research Site, Los Angeles, California
Research Site, Orange, California
Research Site, Boulder, Colorado
Research Site, Fort Myers, Florida
Research Site, Jacksonville, Florida
Research Site, Lakeland, Florida
Research Site, Saint Petersburg, Florida
Research Site, West Palm Beach, Florida
Research Site, Hinsdale, Illinois
Research Site, Fort Wayne, Indiana
Research Site, Bettendorf, Iowa
Research Site, Des Moines, Iowa
Research Site, Iowa City, Iowa
Research Site, Baton Rouge, Louisiana
Research Site, Covington, Louisiana
Research Site, Duluth, Minnesota
Research Site, Rochester, Minnesota
Research Site, Hannibal, Missouri
Research Site, Lincoln, Nebraska
Research Site, Lincoln, Nebraska
Research Site, Clifton Park, New York
Research Site, Asheville, North Carolina
Research Site, Canton, Ohio
Research Site, Columbus, Ohio
Research Site, Maumee, Ohio
Research Site, Tulsa, Oklahoma
Research Site, Portland, Oregon
Research Site, Salem, Oregon
Research Site, Philadelphia, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, Philadelphia, Pennsylvania
Research Site, York, Pennsylvania
Research Site, Watertown, South Dakota
Research Site, Memphis, Tennessee
Research Site, Dallas, Texas
Research Site, Fort Worth, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Irving, Texas
Research Site, Fairfax, Virginia
Research Site, Henrico, Virginia
Research Site, Norfolk, Virginia
Research Site, Renton, Washington
Research Site, Spokane, Washington
Research Site, Tacoma, Washington
Research Site, Appleton, Wisconsin
Research Site, La Crosse, Wisconsin
Research Site, Graz, Not set
Research Site, Rankweil, Not set
Research Site, Wien, Not set
Research Site, Wien, Not set
Research Site, Blumenau, Not set
Research Site, Florianópolis, Not set
Research Site, Fortaleza, Not set
Research Site, Londrina, Not set
Research Site, Porto Alegre, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Taubaté, Not set
Research Site, Vitoria, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Varna, Not set
Research Site, Saint John, New Brunswick
Research Site, Brampton, Ontario
Research Site, Kitchener, Ontario
Research Site, Newmarket, Ontario
Research Site, Sudbury, Ontario
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, St-Jerome, Quebec
Research Site, Saskatoon, Saskatchewan
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changsha, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hefei, Not set
Research Site, Jinan, Not set
Research Site, Kunming, Not set
Research Site, Lanzhou, Not set
Research Site, Liuzhou, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shantou, Not set
Research Site, Shenyang, Not set
Research Site, Shenzhen, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Wenzhou, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xiamen, Not set
Research Site, Yangzhou, Not set
Research Site, Zhengzhou, Not set
Research Site, Brest, Not set
Research Site, Creteil, Not set
Research Site, Gleize, Not set
Research Site, Montpellier, Not set
Research Site, Nimes, Not set
Research Site, Paris CEDEX 14, Not set
Research Site, Paris, Not set
Research Site, Rouen, Not set
Research Site, Saint-Quentin, Not set
Research Site, Strasbourg Cedex, Not set
Research Site, Toulon Cedex 9, Not set
Research Site, Toulouse, Not set
Research Site, Tours, Not set
Research Site, Bad Berka, Not set
Research Site, Berlin, Not set
Research Site, Frankfurt A. Main, Not set
Research Site, Gauting, Not set
Research Site, Gütersloh, Not set
Research Site, Hamburg, Not set
Research Site, Kassel, Not set
Research Site, Kiel, Not set
Research Site, Koblenz, Not set
Research Site, Minden, Not set
Research Site, Rosenheim, Not set
Research Site, Velbert, Not set
Research Site, Würzburg, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Peiraias, Not set
Research Site, Thessaloniki, Not set
Research Site, Thessaloniki, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Gyöngyös - Mátraháza, Not set
Research Site, Kaposvár, Not set
Research Site, Pécs, Not set
Research Site, Szekszárd, Not set
Research Site, Szolnok, Not set
Research Site, Törökbálint, Not set
Research Site, Calicut, Not set
Research Site, Delhi, Not set
Research Site, Delhi, Not set
Research Site, Jaipur, Not set
Research Site, Kolkata, Not set
Research Site, Madurai, Not set
Research Site, Puducherry, Not set
Research Site, Firenze, Not set
Research Site, Lecco, Not set
Research Site, Messina, Not set
Research Site, Napoli, Not set
Research Site, Orbassano, Not set
Research Site, Padova, Not set
Research Site, Parma, Not set
Research Site, Peschiera Del Garda, Not set
Research Site, Rozzano, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Chuo-ku, Not set
Research Site, Hamamatsu-shi, Not set
Research Site, Hamamatsu-shi, Not set
Research Site, Hidaka-shi, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Kumamoto-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Sunto-gun, Not set
Research Site, Wakayama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Busan, Not set
Research Site, Cheongju-si, Not set
Research Site, Jinju-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon-si, Not set
Research Site, Suwon, Not set
Research Site, Cdmx, Not set
Research Site, Del. Cuauhtemoc, Not set
Research Site, Mexico, Not set
Research Site, San Luis Potosí, Not set
Research Site, Arequipa, Not set
Research Site, Concepción, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Bydgoszcz, Not set
Research Site, Bystra, Not set
Research Site, Grudziądz, Not set
Research Site, Kielce, Not set
Research Site, Koszalin, Not set
Research Site, Olsztyn, Not set
Research Site, Poznań, Not set
Research Site, Przemysl, Not set
Research Site, Racibórz, Not set
Research Site, Radom, Not set
Research Site, Siedlce, Not set
Research Site, Las Palmas de Gran Canaria, Not set
Research Site, Lugo, Not set
Research Site, Madrid, Not set
Research Site, Santander, Not set
Research Site, Sevilla, Not set
Research Site, Valencia, Not set
Research Site, Zaragoza, Not set
Research Site, Gävle, Not set
Research Site, Linköping, Not set
Research Site, Lund, Not set
Research Site, Stockholm, Not set
Research Site, Uppsala, Not set
Research Site, Hsinchu, Not set
Research Site, Taichung, Not set
Research Site, Tainan City, Not set
Research Site, Taipei City, Not set
Research Site, Taipei, Not set
Research Site, Taoyuan City, Not set
Research Site, Adana, Not set
Research Site, Ankara, Not set
Research Site, Edirne, Not set
Research Site, Istanbul, Not set
Research Site, Izmir, Not set
Research Site, Aberdeen, Not set
Research Site, Cambridge, Not set
Research Site, Cardiff, Not set
Research Site, Cheltenham, Not set
Research Site, Edinburgh, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Middlesborough, Not set
Research Site, Newcastle-Upon-Tyne, Not set
Research Site, Taunton, Not set
Research Site, Hanoi, Not set
Research Site, Ho Chi Minh city, Not set
Research Site, Ho Chi Minh, Not set
Conditions: NSCLC
Study of Durvalumab+Olaparib or Durvalumab After Treatment With Durvalumab and Chemotherapy in Patients With Lung Cancer (ORION)
Active Not Recruiting
This is a randomized, double-blind, multi-center, global Phase II study to determine the efficacy and safety of Durvalumab plus Olaparib combination therapy compared with Durvalumab monotherapy as maintenance therapy in patients whose disease has not progressed following Standard of Care (SoC) platinum-based chemotherapy with Durvalumab as first-line treatment in patients with Stage IV non small-cell lung cancer (NSCLC) with tumors that lack activating epidermal growth factor receptor (EGFR) mut... Read More
This is a randomized, double-blind, multi-center, global Phase II study to determine the efficacy and safety of Durvalumab plus Olaparib combination therapy compared with Durvalumab monotherapy as maintenance therapy in patients whose disease has not progressed following Standard of Care (SoC) platinum-based chemotherapy with Durvalumab as first-line treatment in patients with Stage IV non small-cell lung cancer (NSCLC) with tumors that lack activating epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) fusions. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
06/27/2025
Locations: Research Site, Bonita Springs, Florida +68 locations
Research Site, Bonita Springs, Florida
Research Site, Saint Petersburg, Florida
Research Site, Tallahassee, Florida
Research Site, West Palm Beach, Florida
Research Site, Kansas City, Missouri
Research Site, Bethlehem, Pennsylvania
Research Site, Chattanooga, Tennessee
Research Site, Nashville, Tennessee
Research Site, Houston, Texas
Research Site, Aalst, Not set
Research Site, Leuven, Not set
Research Site, Roeselare, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Deszk, Not set
Research Site, Farkasgyepü, Not set
Research Site, Törökbálint, Not set
Research Site, Ahmedabad, Not set
Research Site, Ahmedabad, Not set
Research Site, Jamnagar, Not set
Research Site, Kochi, Not set
Research Site, Mysuru, Not set
Research Site, Nashik, Not set
Research Site, Nashik, Not set
Research Site, Nashik, Not set
Research Site, Pune, Not set
Research Site, Thiruvananthapuram, Not set
Research Site, Chuo-ku, Not set
Research Site, Kanazawa-shi, Not set
Research Site, Kurume-shi,, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Sunto-gun, Not set
Research Site, Ube-shi, Not set
Research Site, Dongjakgu, Not set
Research Site, Goyang-si, Not set
Research Site, Seodaemun-gu, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suweonsi Paldalgu, Not set
Research Site, Chihuahua, Not set
Research Site, Culiacan, Not set
Research Site, San Luis Potosí, Not set
Research Site, Blaricum, Not set
Research Site, Harderwijk, Not set
Research Site, Tilburg, Not set
Research Site, Białystok, Not set
Research Site, Poznan, Not set
Research Site, Prabuty, Not set
Research Site, Łódź, Not set
Research Site, Arkhangelsk, Not set
Research Site, Chelyabinsk, Not set
Research Site, Kursk, Not set
Research Site, Moscow, Not set
Research Site, Nal'chik, Not set
Research Site, P. Herzen Moscow Oncology Rese, Not set
Research Site, Sochi, Not set
Research Site, St. Petersburg, Not set
Research Site, Yaroslavl, Not set
Research Site, Dnipro, Not set
Research Site, Kharkiv Region, Not set
Research Site, Kirovohrad, Not set
Research Site, Odesa, Not set
Research Site, Uzhhorod, Not set
Research Site, Zaporizhzhia, Not set
Research Site, Dundee, Not set
Research Site, Hull, Not set
Conditions: Non-small Cell Lung Cancer NSCLC
Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
Recruiting
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC).
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Southern Cancer Center Pc, Daphne, Alabama +246 locations
Southern Cancer Center Pc, Daphne, Alabama
Ironwood Cancer and Research Centers, Chandler, Arizona
Arizona Oncology Associates, Pc - Nahoa, Prescott Valley, Arizona
Hoag Memorial Hospital Prebyterian, Newport Beach, California
Compassionate Cancer Care Medical Group, Riverside, California
Sansum Clinic, Santa Barbara, California
Ronald Reagan UCLA Medical Center, Santa Monica, California
UCHealth Memorial Hospital, Colorado Springs, Colorado
Florida Cancer Specialists - South, Fort Myers, Florida
Cancer Specialist of North Florida, Jacksonville, Florida
Cancer Care Centers of Brevard, Inc., Palm Bay, Florida
Woodlands Medical Specialists, Pa, Pensacola, Florida
Florida Cancer Specialists-North, Saint Petersburg, Florida
Emory University - Winship Cancer Institute Wci, Atlanta, Georgia
Illinois Cancer Specialists, Niles, Illinois
American Oncology Partners of Maryland, Bethesda, Maryland
Maryland Oncology Heamtology P.A., Columbia, Maryland
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana Farber Cancer Institute; Inv Drg Svc Pharm, Boston, Massachusetts
Dana Farber Cancer Institute At St. Elizabeth'S Medical Center, Brighton, Massachusetts
Dana Farber Brigham Cancer Center, Foxboro, Massachusetts
Dana Farber At Milford Regional Cancer Center, Milford, Massachusetts
Dana Farber/Bwcc in Affiliation With South Shore Hospital, South Weymouth, Massachusetts
Astera Cancer Care, East Brunswick, New Jersey
Regional Cancer Care Associates LLC, Hackensack, New Jersey
North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists - Bronx, Bronx, New York
North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists- New Hyde Park, New Hyde Park, New York
North Shore Hematology Oncology Associates, Patchogue, New York
North Shore Hematology Oncology Associates DBA NY Cancer and Blood Specialists, Port Jefferson Station, New York
Texas Oncology, P.A., McAllen, Texas
Ut Health San Antonio, San Antonio, Texas
Texas Oncology, P.A., Sugar Land, Texas
Texas Oncology-Tyler, Tyler, Texas
Utah Cancer Specialists IHO Corp, Salt Lake City, Utah
Providence Regional Cancer System, Lacey, Washington
VA Puget Sound Health Care System, Seattle, Washington
Instituto Alexander Fleming, Ciudad Autonoma de Buenos Aires, Not set
Fundacion CENIT para la investigacion en Neurociencias, Ciudad Autonoma de Buenos Aire, Not set
Hospital de La Comunidad, Mar del Plata, Not set
Centro de Investigacion Pergamino Sa, Pergamino, Not set
Instituto de Oncologia de Rosario, Rosario, Not set
Sanatorio Parque, Rosario, Not set
Centro Polivalente de Asistencia E Investigacion Clinica Cer San Juan, San Juan, Not set
Centro de Investigaciones Clinicas. Clinica Viedma S.A., Viedma, Not set
CRSA/ St Andrews Hospital, Adelaide, Not set
Flinders Medical Centre (Fmc), Bedford Park, Not set
PSEHOG (Peninsula and South Eastern Haematology and Oncology Group), Frankston, Not set
St George Public Hospital, Kogarah, Not set
Southern Medical Day Care Centre, Wollongong, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Landeskrankenhaus Feldkirch, Feldkirch, Not set
Klinikum Klagenfurt Pulmologie, Klagenfurt, Not set
Karl Landsteiner Institut Fã¼R Lungenforschung Und Pneumologische Onkologie C/O Klinik Floridsdorf, Vienna, Not set
Az Maria Middelares - Campus Maria Middelares, Gent, Not set
Centre hospitalier Jolimont-Lobbes, Haine Saint-Paul, Not set
Jessa Hospital, Hasselt, Not set
Cliniques Saint Pierre Ottignies (CSPO), Ottignies, Not set
Az Nikolaas, Sint-Niklaas, Not set
Personal Oncologia de Precisao - Cenantron, Belo Horizonte, Not set
Fundaco Universidade de Caxias Do Sul- Instituto de Pesquisas Em Saude Ips-Ucs, Caxias do Sul, Not set
Hospital Erasto Gaertner, Curitiba, Not set
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, Not set
Clínica de Neoplasias Litoral Ltda, ItajaĂ-, Not set
Clnica Lacks, Pelotas, Not set
Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Instituto Nacional de Că'Ncer - Inca, Rio de Janeiro, Not set
Centro de Estudos E Pesquisa de Hematologia E Oncologia - Cepho, Santo Andre, Not set
Instituto de Ensino E Pesquisa Sao Lucas, Sao Paulo, Not set
Instituto Do Cancer Brasil - Unidade Taubate, Taubate, Not set
CHU de Quebec -Universite Laval Hopital de L'Enfant-Jesus, Quebec City, Not set
Centro de Estudios Clinicos Saga Spa, Santiago de Chile, Not set
ONCOVIDA, Santiago, Not set
Orlandi Oncologia, Santiago, Not set
Oncocentro Apys, Vina Del Mar, Not set
Centro de Investigaciones Clinicas Vina Del Mar, ViĂąa Del Mar, Not set
Peking University Cancer Hospital Beijing Cancer Hospital Beijing Institute For Cancer Research, Beijing Sheng, Not set
Peking University Peoples Hospital, Beijing, Not set
Cangzhou Peoples Hospital, Cangzhou, Not set
First Affiliated Hospital of Medical College of Jilin University, Changchun, Not set
Jilin Cancer Hospital, Changchun, Not set
Hunan Cancer Hospital, Changsha, Not set
University of Electronic Science Technology of China UESTC - Sichuan Cancer Hospital Institute SIC, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Fujian Medical University - Union Hospital Foochow Christian Union Hospital, Fuzhou, Not set
The First Affiliated Hospital Sun Yat-Sen University, Guangzhou, Not set
Affiliated Cancer Hospital and Insititute of Guangzhou Medical University, Guangzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Not set
The First Affiliated Hospital of College of Medicine Zhejiang University, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Inner Mongolia Medical University- the Affiliated Hospital, Hohhot, Not set
Jiamusi Cancer Hospital, Jiamusi, Not set
Linyi Cancer Hospital, Linyi, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Zhongda Hospital, Southeast University, Nanjing, Not set
Shanghai Chest Hospital, Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Liaoning Cancer Hospital & Institute, Shenyang, Not set
Union Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan, Not set
The First Affiliate Hospital of Xi'An Jiaotong University, Xi'an, Not set
Xiangyang Central Hospital, Xianyang, Not set
Henan Cancer Hospital, Zhengzhou, Not set
The First Affiliated Hosptial of Xinjiang Medical University, Ürümqi, Not set
FN Brno Klinika Nemoci Plicnich a TBC, Brno, Not set
Fakultni nemocnice Olomouc FNOL, Olomouc, Not set
Sainte-Catherine Institut du Cancer Avignon-Provence, Avignon, Not set
Hopital Jean Minjoz - CHU de Besancon, Besancon, Not set
Chu de Bordeaux - Hopital Saint Andre, Bordeaux, Not set
Centre Hospitalier Universitaire, CHU, de Poitiers, France, Not set
Hopital Lyon Sud, Lyon, Not set
Centre Leon Berard, Lyon, Not set
Aphm - Hopital Nord, Marseille Cedex 20, Not set
Institut Paoli Calmettes, Marseille, Not set
Chu de Montpellier, Montpellier Cedex 5, Not set
Chu de Nantes, Nantes, Not set
Hopital Prive Du Confluent, Nantes, Not set
Institut Curie, Paris Cedex 05, Not set
Tenon Hospital, Paris, Not set
CHU de Rennes - Hopital Pontchaillou, Rennes, Not set
Hôpital Foch, Suresnes, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Klinikum Chemnitz, Chemnitz, Not set
Universitaetsklinikum Essen, Essen, Not set
Klinikum Esslingen Gmbh, Esslingen, Not set
Universitaetsklinikum Freiburg, Freiburg, Not set
University Hospital Giessen, ZIM IV, Giessen, Not set
External pharmacy Fortuna Herstellung GmbH of main site Universitaetsmedizin Mannheim, Mannheim, Not set
University Hospital Mă Nster, Muenster, Not set
Ludwig-Maximilians University Hospital of Munich, Munich, Not set
Sotiria General Hospital of Chest Diseases, Athens, Not set
Metropolitan Hospital - Athens, Athens, Not set
University General Hospital of Heraklion, Heraklion, Not set
University Hospital of Ioannina Uhi, Ioannina, Not set
Metropolitan Hospital, Neo Faliro, Not set
Olympion Hospital, Patras, Not set
Euromedica General Clinic of Thessaloniki, Thessaloniki, Not set
St. Luke's Hospital, Thessaloniki, Not set
Bioclinic Thessaloniki (Galinos Clinic), Thessalonki, Not set
Tuen Mun Hospital, Hong Kong, Not set
Prince of Wales Hospital / The Chinese University of Hong Kong, Hong Kong, Not set
Queen Mary Hospital, Pok Fu Lam, Not set
National Koranyi Institute For Pulmonology, Budapest, Not set
Veszprem Megyei Tudogyogyintezet Farkasgyepu, Farkasgyepu, Not set
Bkmk Hospital, KecskemĂŠt, Not set
Fejer Megyei Szent Gyorgy Korhaz Pulmonologiai Osztaly, Szekesfehervar, Not set
Hetenyi G Korhaz, Onkologiai Kozpont, Szolnok, Not set
Reformatus Pulmonologiai Centrum, Torokbalint, Not set
Istituto Di Candiolo Irccs, Candiolo, Not set
Ospedale San Luca, Lucca, Not set
Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano, Not set
IFO Regina Elena, Rome, Not set
Ospedale S. Maria Della Misericordia, Udine, Not set
Asst Sette Laghi, Varese, Not set
Azienda Ospedaliera Universitaria Integrata Verona Ospedale Borgo Roma Crc - Centro Ricerche Clinich, Verona, Not set
NHO Shikoku Cancer Center, Ehime, Not set
Kurume University Hospital, Fukoka, Not set
Kyushu Cancer Center, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Not set
Teine Keijinkai Hospital, Hokkaido, Not set
Hyogo Medical University Hospital, Hyogo, Not set
Kanazawa University Hospital, Ishikawa, Not set
Kanagawa Cancer Center, Kanagawa, Not set
Kitasato University hospital, Kanagawa, Not set
Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc. Saiseikai Kumamoto Hospital, Kumamoto, Not set
University Hospital Kyoto Prefectual University of Medicine, Kyoto, Not set
Matsusaka Municipal Hospital, Mie, Not set
Sendai Kousei Hospital, Miyagi, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Osaka International Cancer Institute, Osaka, Not set
Osaka Toneyama Medical Center, Osaka, Not set
Kansai Medical University Hospital, Osaka, Not set
NHO Kinki-Chuo Chest Medical Center, Osaka, Not set
Dokkyo Medical University Hospital, Tochigi, Not set
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Not set
Juntendo University Hospital, Tokyo, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Toho University Omori Medical Center, Tokyo, Not set
Iwakuni Clinical Center, Yamaguchi, Not set
Yamaguchi-Ube Medical Center, Yamaguchi, Not set
Yamanashi Prefectural Central Hospital, Yamanashi, Not set
Chungbuk National University Hospital, Cheongjusi, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Samsung Medical Center, Gangnam-Gu, Not set
National Cancer Center, Goyang-si, Not set
Gyeongsang National University Hospital, Jinju-si Gyeongsangnam-do, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Asan Medical Center, Seoul, Not set
Yonsei University Health System - Severance Hospital, Seoul, Not set
The Catholic Univ. of Korea, Seoul St. Marys Hospital, Seoul, Not set
Cryptex Investigacion Clinica Sa de Cv, Cuauhtemoc, Not set
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Not set
Instituto Nacional de Cancerologia, Mexico City, Not set
Centro de Investigacion Clinica de Oaxaca CICLO, Oaxaca, Not set
Amphia Ziekenhuis, Breda, Not set
Leiden University Medical Center, Leiden, Not set
Jeroen Bosch Ziekenhuis Jbz, s-Hertogenbosch, Not set
II Klinika Chorob Pluc i Gruzlicy, Bialystok, Not set
Centrum Terapii Wspolczesnej, Lodz, Not set
Instytut Centrum Zdrowia Matki Polki (Iczmp), Lodz, Not set
SPSK4, Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin, Not set
Med Polonia Sp. Z O.O., Poznan, Not set
Maria Sklodowska-Curie National Research Institute of Oncology, Warszawa, Not set
Fundacao Champalimaud, Lisbon, Not set
IPO Porto Francisco Gentil, E.P.E., Porto, Not set
Institute of Oncology Prof. Dr. Ion Chiricuta, Cluj- Napoca, Not set
Onco Clinic Consult Sa, Craiova, Not set
Centrul de Oncologie Sfantu Nectarie, Craiova, Not set
SC Oncomed SRL, Jud Timis, Not set
Oncocenter Oncologie Clinica S.R.L, Timisoara, Not set
Vall Hebron University Hospital, Barcelona, Not set
Hospital Clinic I Provincial de Barcelona, Barcelona, Not set
Hospital Universitario Arnau de Vilanova, Lleida, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Clinico San Carlos, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Regional Universitario Malaga, Malaga, Not set
CHUO, Ourense, Not set
Hosp Univ Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen de Valme, Sevilla, Not set
Hospital Universitario y Politecnico de La Fe, Valenica, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Kantonsspital Baselland, Liestal, Not set
Kantonsspital St. Gallen, St. Gallen, Not set
Spital Sts Ag, Thun, Not set
Changhua Christian Hospital, Changhua, Not set
China Medical University Hospital, Hsia, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Tri-Service General Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital, Taoyuan, Not set
Faculty of Medicine Chulalongkorn University, Bangkok, Not set
Ramathibodi Hospital, Bangkok, Not set
Siriraj Hospital, Bangkok, Not set
Chiang Mai University CMU - Maharaj Nakhon Chiang Mai Hospital Nakorn Chiang Mai Hospital, Chiang Mai, Not set
Prince of Songkla University PSU - Faculty of Medicine, Hat Yai, Not set
Khon Kaen University - Faculty of Medicine-Srinagarind Hospital, Mueang Nonthaburi, Not set
Baskent University, Adana, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Akdeniz University Hospital, Antalya, Not set
Medipol Mega University Hospital, Bağcılar, Not set
Memorial Ankara Hospital, Cankaya/Ankara, Not set
Istanbul Medeniyet University Medical Faculty, Istanbul, Not set
Adana Acibadem Hospital, Seyhan, Not set
Barts Health NHS Trust, London, Not set
Conditions: Metastatic Non Small Cell Lung Cancer
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)
Recruiting
This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma.
This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma. Read Less
Gender:
ALL
Ages:
21 years and below
Trial Updated:
06/25/2025
Locations: Sydney children Hospital, Sydney, Randwick +141 locations
Sydney children Hospital, Sydney, Randwick
Children's Cancer Centre, Monash Children's Hospital, Clayton, Not set
Oncology/Haematology Department, Perth Children's Hospital, Nedlands, Not set
Children's Cancer & Haematology Services, John Hunter Children's Hospital, New Lambton Heights, Not set
Australian and New Zealand Children's Hematology/oncology Group, Sydney, Not set
sydney children Hospital, Sydney, Not set
Cancer Centre for Children, The Children's Hospital, Westmead, Not set
Medical University Graz, Graz, Not set
Landeskrankenhaus-Universitätsklinikum Innsbruck, Innsbruck, Not set
Kepler Universitatsklinikum Linz, Linz, Not set
Universitastsklinikum Salzburg, Salzburg, Not set
St Anna'S Children Hospital, Vienna, Not set
Hôpital Universitaire des Enfants Reine Fabiola (ULB), Brussels, Not set
Cliniques Universitaires Saint-Luc (UCL), Brussel, Not set
University Hospital Gent, Gent, Not set
University Hospitals Leuven, Leuven, Not set
CHR Citadelle, Liège, Not set
University Hospital Motol, Prague,, Prague
Klinika dětské onkologie FN Brno, Brno, Not set
Aarhus University Hospital, Aarhus, Not set
Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Not set
The Hans Christian Andersen Children's Hospital, University of Southern Denmark, Odense, Not set
New Children's Hospital, Helsinki University Hospital, Helsinki and Uusimaa Hospital District, Helsinki, Not set
Kuopio University Hospital, Kuopio, Not set
Oulu University Hospital, Oulu, Not set
Tampere University Hospital, Tampere, Not set
Turku University Hospital, Turku, Not set
Gustave Roussy, Villejuif, Val De Marne
CHU d'AMIENS, Amiens, Not set
CHU angers, Angers, Not set
CHU-Pôle Médico-Chirurgical de l'Enfant et l'Adolescant, Besançon, Not set
CHU Bordeaux, Bordeaux, Not set
Groupe Hospitalier Pellegrin - Chu - Bordeaux, Bordeaux, Not set
CHU Brest, Brest, Not set
CHU Brest - Hôpital du Morvan, Brest, Not set
Centre François Baclesse, Caen, Not set
CHU de Caen, Caen, Not set
CHU Estaing, Clermont-Ferrand, Not set
Centre Georges-François Leclerc, Dijon, Not set
Hopital d'enfants Marechal de lattre, Dijon, Not set
Hôpital Couple-Enfant CHU de Grenoble, Grenoble, Not set
Chu de La Reunion - St Denis, La Réunion, Not set
centre Oscar lambert, Lille, Not set
Hôpital de la Mère et de l'Enfant - CHU Limoges, Limoges, Not set
Centre Léon Berard, Lyon, Not set
hopital la Timone, Marseille, Not set
CHRU Nancy-Hôpital Brabois Enfant, Nancy, Not set
Institut de cancérologie de Loraine, Nancy, Not set
Centre Antoine Lacassagne, Nice, Not set
CHU Nice-Hôpital d'Archet, Nice, Not set
Hôpital Armand Trousseau, Paris, Not set
institut Curie, Paris, Not set
CHU Poitiers, Poitiers, Not set
Hôpital Américain -CHU Reims, Reims, Not set
Centre Eugène Marquis, Rennes, Not set
CHU Rennes, Rennes, Not set
Hôpital des Enfants - CHU Rouen, Rouen, Not set
Institut de cancérologie de l'Ouest - Sité René Gauducheau, Saint-Herblain, Not set
CHU Saint Etienne, Saint-Étienne, Not set
CHU Haute Pierre, Strasbourg, Not set
Institut de Cancérologie Strasbourg, Strasbourg, Not set
Hopital des enfants-CHU Toulouse, Toulouse, Not set
IUCT Oncopole, Toulouse, Not set
CHU Tours Hôpital Clocheville, Tours, Not set
charite universitatsmedizin Berlin, Berlin, Not set
Uniklinik Köln, Klinik und Poliklinik für Kinder und Jugendmedizin, Köln, Not set
Children's General Hospital "I AGHIA SOFIA", Athens, Not set
Children's General Hospital "P. & A. KYRIAKOU", Athens, Not set
"MITERA" Private, General, Obstetrics - Gynaecology, Paediatric Clinic S.A., Athens, Not set
Children's General Hospital "AGHIA SOFIA", Athens, Not set
University General Hospital of Heraklion (UnGHH), Heraklion, Not set
University General Hospital of Thessaloniki "AHEPA", Thessaloniki, Not set
General Hospital of Thessaloniki "IPPOKRATIO", Thessaloniki, Not set
RAMBAM Medical Center, Haifa, Not set
A.O.U Policlinico di Bari, Bari, Not set
Spedali civili Ospedale Dei Bambini Oncoematologia pediatrica e TMO, Brescia, Not set
policlinico rodolico San marco, Catania, Not set
Azienda ospedaliero universtaria Anna Meyer, Firenze, Not set
instituto Giannina Gaslini genova, Genova, Not set
IRCCS "Istituto Giannina Gaslini", Genova, Not set
Azienda Policlinico di Modena, Modena, Not set
Azienda ospedaliero universitaria di Parma, Parma, Not set
Policlino San matteo di Pavia, Pavia, Not set
U.O Pediatria, SS Oncoematologia pediatrica, Rimini, Not set
IRCCS Burlo Garoflo oncoematologia, Trieste, Not set
U.O.C oncoematologia pediatrica ospedale Donna Bambino, Verona, Not set
Vilnius University Hospital Santaros Klinikos, Vilnius, Not set
National Cancer Institute, Vilnius, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Princess Maxima center, Utrecht, Not set
Haukeland University Hospital, Haukeland, Not set
Oslo University Hospital, Oslo, Not set
University Hospital Northern Norway, Tromsoe, Tromsø, Not set
St Olavs Hospital,, Trondheim, Not set
Children's University Hospital Banská Bystrica, Banská Bystrica, Not set
NÚDCH- National Institute of Children's Diseases,, Bratislava, Not set
Children's University Hospital Košice, Košice, Not set
University medical center Ljubljana, University Children's Hospital Ljubljana, Slovenia, Ljubljana, Not set
Hospital Universitario Son Espases, Balea, Not set
Hospital Universitario Vall D´Hebron, Barcelona, Not set
Hospital Universitario Cruces, Cruces, Not set
Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital Universitario Infantil Niño Jesús, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Málaga, Málaga, Not set
Hospital Universitario Donostia, San Sebastián, Not set
Hospital Clínico Universitario de Santiago, Santiago De Compostela, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
Hospital Universitario Politécnico de La FE, Valence, Not set
Sahlgrenska University Hospital, Gothenburg, Not set
Linköping University Hospital, Linköping, Not set
Skåne University Hospital, Lund, Not set
Karolinska University Hospital, Stockholm, Stockholm, Not set
Norrland University Hospital, Umeå, Not set
Uppsala University Hospital, Uppsala, Not set
Kantonsspital Aarau AG Klinik für Kinder und Jugendliche, Aarau, Not set
Universitäts-Kinderspital beider Basel (UKBB), Basel, Not set
Ospedale San Giovanni Pediatria, Emato-oncologia pediatrica, Bellinzona, Not set
Inselspital, Universitätsklinik für Kinderheilkunde, Bern, Not set
HUG Hôpitaux Universitaires de Genève Unité d'Hémato-Oncologie Pédiatrique, Geneva, Not set
CHUV - Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
Luzerner Kantonsspital, Kinderspital pädiatrische Hämatologie/Onkologie, Lucerne, Not set
Ostschweizer Kinderspital Hämatologie/Onkologie Claudiusstrasse 6, Saint Gallen, Not set
Division of Pediatric Oncology Universitäts-Kinderspital Zürich, Zürich, Not set
Royal Aberdeen Children's Hospital, Aberdeen, Not set
Royal Belfast Hospital for Sick Children, Belfast, Not set
Birmingham children's Hospital, Birmingham, Not set
University Hospitals Birmingham Queen Elisabeth Hospital(UHB), Birmingham, Not set
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, Not set
Addenbrookes Hospital, Cambridge, Cambridge, Not set
Noah's Ark Children's Hospital for Wales - Cardiff, Cardiff, Not set
Royal Hospital for Sick Children - Edinburgh, Edinburgh, Not set
Royal Hospital for Children Glasgow, Glasgow, Not set
Leeds General Infirmary, Leeds, Not set
Alder Hey Children's Hospital - Liverpool, Liverpool, Not set
Great Ormond Street Hospital - London, London, Not set
Royal Manchester Children's Hospital, Manchester, Not set
Royal Victoria Infirmary, Newcastle, Newcastle, Not set
Nottingham Children's Hospital, Nottingham, Not set
Sheffield Children's Hospital, Sheffield, Not set
Southampton General Hospital, Southampton, Not set
Royal Marsden Hospital, Sutton, Not set
Conditions: High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)
Completed
The purpose of this study is to evaluate the efficacy of pembrolizumab (MK-3745) in the neoadjuvant (prior to surgery) or adjuvant (after surgery) treatment of previously untreated adults with gastric and gastroesophageal junction (GEJ) adenocarcinoma.
The primary study hypotheses are that:
* Neoadjuvant and adjuvant pembrolizumab plus chemotherapy, followed by adjuvant pembrolizumab is superior to neoadjuvant and adjuvant placebo plus chemotherapy, followed by adjuvant placebo in terms of Eve... Read More
The purpose of this study is to evaluate the efficacy of pembrolizumab (MK-3745) in the neoadjuvant (prior to surgery) or adjuvant (after surgery) treatment of previously untreated adults with gastric and gastroesophageal junction (GEJ) adenocarcinoma.
The primary study hypotheses are that:
* Neoadjuvant and adjuvant pembrolizumab plus chemotherapy, followed by adjuvant pembrolizumab is superior to neoadjuvant and adjuvant placebo plus chemotherapy, followed by adjuvant placebo in terms of Event-free Survival (EFS) based on Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1), and
* Neoadjuvant pembrolizumab plus chemotherapy is superior to neoadjuvant placebo plus chemotherapy in terms of rate of Pathological Complete Response (pathCR) at the time of surgery.
With Amendment 10, upon study completion, participants will be discontinued and may be enrolled in an extension study. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2025
Locations: City of Hope ( Site 0005), Duarte, California +170 locations
City of Hope ( Site 0005), Duarte, California
Yale Cancer Center ( Site 0016), New Haven, Connecticut
Georgetown University ( Site 0015), Washington, District of Columbia
Northwestern University - Robert H. Lurie Comprehensive Cancer Center ( Site 0018), Chicago, Illinois
The University of Chicago Medical Center ( Site 0004), Chicago, Illinois
Roswell Park Cancer Institute ( Site 0001), Buffalo, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0019), New York, New York
Memorial Sloan Kettering ( Site 0024), New York, New York
Weill Cornell Medical Center ( Site 0023), New York, New York
University of Rochester ( Site 0011), Rochester, New York
Fox Chase Cancer Center ( Site 0006), Philadelphia, Pennsylvania
Temple University Hospital ( Site 0026), Philadelphia, Pennsylvania
University of Utah, Huntsman Cancer Institute ( Site 0012), Salt Lake City, Utah
Virginia Cancer Specialists, PC ( Site 0010), Fairfax, Virginia
Institut Jules Bordet ( Site 0480), Brussels, Bruxelles-Capitale, Region De
Hopital Erasme ULB ( Site 0484), Brussels, Bruxelles-Capitale, Region De
UCL Saint Luc ( Site 0479), Bruxelles, Bruxelles-Capitale, Region De
Grand Hopital de Charleroi ( Site 0478), Charleroi, Hainaut
CHU de Liege ( Site 0482), Liège, Liege
CHU UCL Namur Site de Godinne ( Site 0485), Yvoir, Namur
UZ Gent ( Site 0486), Gent, Oost-Vlaanderen
UZ Leuven ( Site 0483), Leuven, Vlaams-Brabant
AZ Groeninge ( Site 0481), Kortrijk, West-Vlaanderen
Instituto do Cancer do Ceara ( Site 0311), Fortaleza, Ceara
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0308), Porto Alegre, Rio Grande Do Sul
CEPON - Centro de Pesquisas Oncologicas ( Site 0302), Florianopolis, Santa Catarina
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0301), Barretos, Sao Paulo
Hospital de Base de Sao Jose de Rio Preto ( Site 0304), Sao Jose Rio Preto, Sao Paulo
Instituto Nacional Do Cancer Jose Alencar Gomes Da Silva ( Site 0307), Rio de Janeiro, Not set
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0305), Sao Paulo, Not set
Hospital Israelita Albert Einstein ( Site 0309), Sao Paulo, Not set
Cross Cancer Institute ( Site 0033), Edmonton, Alberta
Moncton Hospital - Horizon Health Network ( Site 0038), Moncton, New Brunswick
Sunnybrook Research Institute ( Site 0032), Toronto, Ontario
CISSS de la Monteregie-Centre ( Site 0039), Greenfield Park, Quebec
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0040), Montreal, Quebec
Jewish General Hospital ( Site 0034), Montreal, Quebec
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0035), Sherbrooke, Quebec
CHU de Quebec - Hotel-Dieu de Quebec ( Site 0042), Quebec, Not set
Instituto Clinico del Sur. ICOS ( Site 0290), Temuco, Araucania
Hospital Regional Rancagua Libertador Bernardo O Higgins ( Site 0299), Rancagua, Lbtdr Gen Bernardo O Higgins
Fundacion Arturo Lopez Perez FALP ( Site 0286), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile ( Site 0285), Santiago, Region M. De Santiago
Hospital Clinico Universidad de Chile ( Site 0287), Santiago, Region M. De Santiago
Beijing Cancer Hospital ( Site 0221), Beijing, Beijing
Zhejiang Cancer Hospital ( Site 0231), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital ( Site 0233), Hangzhou, Zhejiang
SA Pohja-Eesti Regionaalhaigla ( Site 0526), Tallinn, Harjumaa
Hopital Prive Jean Mermoz ( Site 0462), Lyon, Auvergne
Institut Paoli Calmettes ( Site 0472), Marseille, Bouches-du-Rhone
CHU Reims - Hopital Robert Debre ( Site 0465), Reims, Champagne-Ardenne
CHU Brest - Institut de Cancerologie et d Hematologie ( Site 0474), Brest, Finistere
CHU Toulouse - Hopital Rangueil ( Site 0470), Toulouse, Haute-Garonne
Institut du Cancer de Montpellier ( Site 0473), Montpellier, Herault
Centre Eugene Marquis ( Site 0466), Rennes, Ille-et-Vilaine
Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0469), Saint Herblain, Loire-Atlantique
CHRU Lille - Hopital Claude Huriez ( Site 0461), Lille, Nord
CHU Poitiers - Pole Regional de Cancerologie ( Site 0467), Poitiers, Vienne
CHU Hopital Saint Antoine ( Site 0471), Paris, Not set
Institut Mutualiste Montsouris ( Site 0463), Paris, Not set
Klinikum Esslingen GmbH ( Site 0453), Esslingen, Baden-Wurttemberg
Universitaetsklinikum Freiburg ( Site 0450), Freiburg, Baden-Wurttemberg
Klinikum der Universitaet in Muenchen ( Site 0446), Muenchen, Bayern
Medizinische Hochschule Hannover ( Site 0449), Hannover, Niedersachsen
Kliniken Essen Mitte Gmbh Evang. Huyssens Stiftung ( Site 0445), Essen, Nordrhein-Westfalen
Medizinische klinilk und Poliklinik Johannes Gutenberg Univ ( Site 0455), Mainz, Rheinland-Pfalz
Universitaetsklinikum Carl Gustav Carus der TU Dresden ( Site 0448), Dresden, Sachsen
Haematologisch-Onkologische Praxis Eppendorf Facharztzentrum Eppendorf - Hope ( Site 0454), Hamburg, Not set
Integra Cancer Institute ( Site 0262), Guatemala, Not set
Grupo Medico Angeles ( Site 0261), Guatemala, Not set
Centro Medico Integral De Cancerología (CEMIC) ( Site 0260), Quetzaltenango, Not set
Soroka University M.C ( Site 0385), Beer Sheva, HaDarom
Meir medical center ( Site 0386), Kfar Saba, HaMerkaz
Sourasky Medical Center. ( Site 0382), Tel-Aviv, Tell Abib
Rambam Health Care Campus ( Site 0381), Haifa, Not set
Hadassah Medical Center. Ein Kerem ( Site 0383), Jerusalem, Not set
Rabin-Medical Center ( Site 0384), Petah Tikva, Not set
Sheba Medical center ( Site 0387), Ramat Gan, Not set
IRCCS Istituto Oncologico Veneto ( Site 0431), Padova, Abruzzo
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0430), Milano, Lombardia
Istituto Clinico Humanitas Research Hospital ( Site 0432), Rozzano, Milano
IRCCS Policlinico San Donato ( Site 0433), San Donato Milanese, Milano
Azienda Ospedaliero Universitaria di Modena Policlinico ( Site 0429), Modena, Not set
Seconda Universita Napoli ( Site 0436), Napoli, Not set
A.O.U. Santa Maria della Misericordia di Udine ( Site 0434), Udine, Not set
Aichi Cancer Center Hospital ( Site 0165), Nagoya, Aichi
National Cancer Center Hospital East ( Site 0178), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 0186), Matsuyama, Ehime
Hokkaido University Hospital ( Site 0160), Sapporo, Hokkaido
Hyogo Cancer Center ( Site 0182), Akashi, Hyogo
Kobe University Hospital ( Site 0188), Kobe, Hyogo
Kobe City Medical Center General Hospital ( Site 0181), Kobe, Hyogo
Ibaraki Prefectural Central Hospital ( Site 0177), Kasama, Ibaraki
Iwate Medical University Hospital ( Site 0184), Shiwa-gun, Iwate
St. Marianna University School of Medicine Hospital ( Site 0187), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 0167), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 0190), Hirakata, Osaka
Osaka University Hospital ( Site 0162), Suita, Osaka
Osaka Medical College Hospital ( Site 0168), Takatsuki, Osaka
Saitama Cancer Center ( Site 0170), Kitaadachi-gun, Saitama
Shizuoka Cancer Center Hospital and Research Institute ( Site 0176), Sunto-gun, Shizuoka
Chiba Cancer Center ( Site 0180), Chiba, Not set
National Hospital Organization Kyushu Cancer Center ( Site 0172), Fukuoka, Not set
Kyushu University Hospital ( Site 0173), Fukuoka, Not set
Gifu University Hospital ( Site 0166), Gifu, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 0171), Hiroshima, Not set
Kochi Health Sciences Center ( Site 0189), Kochi, Not set
Kumamoto University Hospital ( Site 0164), Kumamoto, Not set
Niigata Cancer Center Hospital ( Site 0169), Niigata, Not set
Osaka International Cancer Institute ( Site 0161), Osaka, Not set
Osaka General Medical Center ( Site 0159), Osaka, Not set
National Cancer Center Hospital ( Site 0179), Tokyo, Not set
Tokyo Metropolitan Komagome Hospital ( Site 0183), Tokyo, Not set
The Cancer Institute Hospital of JFCR ( Site 0185), Tokyo, Not set
Toyama Prefectural Central Hospital ( Site 0163), Toyama, Not set
Chonnam National University Hwasun Hospital ( Site 0083), Hwasun Gun, Jeonranamdo
Seoul National University Bundang Hospital ( Site 0085), Seongnam-si, Kyonggi-do
Kyungpook National University Chilgok Hospital ( Site 0089), Daegu, Taegu-Kwangyokshi
Gachon University Gil Medical Center ( Site 0087), Incheon, Not set
Korea University Anam Hospital ( Site 0084), Seoul, Not set
Seoul National University Hospital -SNUH- ( Site 0080), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 0081), Seoul, Not set
Asan Medical Center ( Site 0082), Seoul, Not set
Gangnam Severance Hospital ( Site 0088), Seoul, Not set
SMG-SNU BORAMAE Medical Center ( Site 0086), Seoul, Not set
Riga East Clinical University Hospital ( Site 0550), Riga, Not set
LSMUL Kauno Klinikos ( Site 0570), Kaunas, Not set
Nacionalinis Vezio Institutas ( Site 0569), Vilnius, Not set
Vilniaus Universiteto Ligonine Santaros Klinikos ( Site 0568), Vilnius, Not set
Hospital Kuala Lumpur ( Site 0146), Kuala Lumpur, Not set
University Malaya Medical Centre ( Site 0143), Kuala Lumpur, Not set
St. Luke s Medical Center ( Site 0622), Quezon City, National Capital Region
Wojewodzki Szpital Specjalistyczny we Wroclawiu ( Site 0358), Wroclaw, Dolnoslaskie
Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie ( Site 0351), Lublin, Lubelskie
Szpital Uniwersytecki w Krakowie ( Site 0352), Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0349), Warszawa, Mazowieckie
Mazowiecki Szpital Onkologiczny ( Site 0363), Wieliszew, Mazowieckie
Szpital Specjalistyczny w Koscierzynie Sp. z o.o. ( Site 0353), Koscierzyna, Pomorskie
Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 0354), Bielsko-Biala, Slaskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0361), Gliwice, Slaskie
SPZOZ WSS nr 3 w Rybniku ( Site 0357), Rybnik, Slaskie
Kaluga Regional Clinical Oncology Center ( Site 0345), Kaluga, Kaluzskaja Oblast
SBHI Leningrad Regional Clinical Hospital ( Site 0496), Saint Petersburg, Leningradskaya Oblast
National Medical and Surgical Center n.a. N.I.Pirogov ( Site 0338), Moscow, Moskva
Blokhin National Medical Oncology ( Site 0494), Moscow, Moskva
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0344), Saint Petersburg, Sankt-Peterburg
Leningrad Regional Oncology Center ( Site 0335), Saint-Petersburg, Sankt-Peterburg
City clinical oncological dispensary ( Site 0336), Sankt-Petersburg, Sankt-Peterburg
Tomsk Scientific Research Institute of Oncology ( Site 0337), Tomsk, Tomskaya Oblast
National University Hospital ( Site 0095), Singapore, Central Singapore
National Cancer Centre Singapore ( Site 0097), Singapore, Central Singapore
Oncocare Cancer Centre ( Site 0096), Singapore, Central Singapore
Taipei Medical University Shuang Ho Hospital ( Site 0068), New Taipei, Not set
National Cheng Kung University Hospital ( Site 0067), Tainan, Not set
National Taiwan University Hospital ( Site 0063), Taipei, Not set
Mackay Memorial Hospital ( Site 0065), Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center ( Site 0066), Taipei, Not set
Chang Gung Medical Foundation. Linkou ( Site 0064), Taoyuan, Not set
City Clinical Hosp.4 of DCC ( Site 0325), Dnipro, Dnipropetrovska Oblast
MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council ( Site 0589), Kryviy Rih, Dnipropetrovska Oblast
Ivano-Frankivsk Regional Oncology Clinical Dispensary ( Site 0321), Ivano-Frankivsk, Ivano-Frankivska Oblast
Communal non profit enterprise Regional Clinical Oncology Center ( Site 0591), Kharkiv, Kharkivska Oblast
National Cancer Institute of the MoH of Ukraine ( Site 0319), Kyiv, Kyivska Oblast
Kyiv City Clinical Oncology Center ( Site 0590), Kyiv, Kyivska Oblast
University Hospitals Bristol NHS Foundation Trust ( Site 0407), Bristol, Bristol, City Of
Ninewells Hospital and Medical School ( Site 0406), Dundee, Dundee City
Royal Free London NHS Foundation Trust ( Site 0403), London, London, City Of
The Royal Marsden Foundation Trust ( Site 0405), London, London, City Of
Imperial College Healthcare NHS Trust ( Site 0402), London, London, City Of
Royal Marsden NHS Foundation Trust ( Site 0400), Sutton, Surrey
The Christie NHS Foundation Trust ( Site 0397), Manchester, Not set
Conditions: Gastric Cancer, Gastroesophageal Junction Cancer
Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)
Recruiting
This is a global, multicenter, randomized, open-label study, with an adaptive design. The main objective of the study is to measure the efficacy and safety of BT8009 (zelenectide pevedotin) as monotherapy and in combination with pembrolizumab in participants with locally advanced or metastatic urothelial cancer (UC). The study includes a dose selection phase followed by an adaptive design continuation. The study is comprised of 2 cohorts. Cohort 1 will include participants who have not received... Read More
This is a global, multicenter, randomized, open-label study, with an adaptive design. The main objective of the study is to measure the efficacy and safety of BT8009 (zelenectide pevedotin) as monotherapy and in combination with pembrolizumab in participants with locally advanced or metastatic urothelial cancer (UC). The study includes a dose selection phase followed by an adaptive design continuation. The study is comprised of 2 cohorts. Cohort 1 will include participants who have not received any prior systemic therapy for locally advanced or metastatic UC and are eligible to receive platinum-based chemotherapy, whereas Cohort 2 will include participants who have received ≥ 1 prior systemic therapy for locally advanced or metastatic UC. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +169 locations
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Virginia K. Crosson Cancer Center at St. Jude Medical Center, Fullerton, California
University of California - Irvine Medical Center, Orange, California
Adventist Health St. Helena, Saint Helena, California
University of California, San Francisco (UCSF), San Francisco, California
Rocky Mountain Cancer Center, Denver, Colorado
Yale University School of Medicine - Yale Cancer Center, New Haven, Connecticut
Medical Oncology Hematology Consultants, Newark, Delaware
Cancer Specialists of North Florida, Jacksonville, Florida
Mount Sinai Medical Center of Florida, Inc., Miami Beach, Florida
University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida
AP Medical Research, Miami, Florida
Moffitt, Tampa, Florida
Southern Illinois University (SIU) - Simmons Cancer Institute, Springfield, Illinois
Mission Cancer + Blood, Des Moines, Iowa
University of Kansas Cancer Center, Westwood, Kansas
UofL Health Brown Cancer Center, Louisville, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Princess Margaret Hospital, Grand Rapids, Michigan
Nebraska Cancer Specialists, Omaha, Nebraska
XCancer Omaha/Urology Cancer Center, Omaha, Nebraska
Astera Cancer Care, East Brunswick, New Jersey
Summit Health (New Jersey Urology), Voorhees, New Jersey
Montefiore Medical Center, Bronx, New York
Columbia University Irving Medical Center, New York, New York
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Medical University of South Carolina (MUSC) - Hollings Cancer Center, Charleston, South Carolina
Carolina Urologic Research Center, Myrtle Beach, South Carolina
SCRI Oncology Partners, Nashville, Tennessee
The Center for Cancer and Blood Disorders, Fort Worth, Texas
MD Anderson Cancer Center, Houston, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Centro de Diagnostico Urologico S.R.L., Buenos Aires, Not set
Hospital Britanico de Buenos Aires, Buenos Aires, Not set
Hospital Sirio Libanes de Buenos Aires, Buenos Aires, Not set
Instituto Alexander Fleming, Buenos Aires, Not set
Fundacion Medica Rio Negro y Neuquen, Cipolletti, Not set
Centro Medico Privado (CEMAIC), Córdoba, Not set
Fundación CORI para la investigación y Prevención del Cancer, La Rioja, Not set
Centro De Investigacion Pergamino S.A., Pergamino, Not set
Instituto de Oncologia de Rosario, Santa Fe, Not set
Clinica Viedma S.A., Viedma, Not set
Cancer Research SA, Adelaide, Not set
Mater Misericordiae Ltd, South Brisbane, Brisbane, Not set
Townsville Hospital and Health Service, Douglas, Not set
Barwon Health, Geelong, Not set
Calvary Mater Newcastle, Hunter, Not set
Sir Charles Gairdner Hospital, Nedlands, Not set
Blacktown Hospital, New South Wales, Not set
Prince of Wales Hospital, Randwick, Not set
Icon Cancer Centre, South Brisbane, Not set
Gold Coast University Hospital, Southport, Not set
Princess Alexandra Hospital, Woolloongabba, Not set
Urologie und Andrologie Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
Krankenhaus der Barmherzigen Brüder Wien, Wien, Not set
Medizinische Universitaet Wien, Wien, Not set
ASBL Grand Hôpital de Charleroi (GHdC), Site Notre Dame, Charleroi, Not set
General Hospital Maria Middelares, Gent, Not set
University Hospital Gent, Gent, Not set
Universitaire Ziekenhuizen Leuven, Leuven, Not set
Fundacao PIO XII - Hospital de Amor, Barretos, Not set
CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina, Florianópolis, Not set
Oncosite - Centro de Pesquisa Clinica Em Oncologia, Ijuí, Not set
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa, Porto Alegre, Not set
Hospital Sao Lucas - Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, Not set
Hospital Alemao Oswaldo Cruz, São Paulo, Not set
Hospital A.C. Camargo Cancer Center, São Paulo, Not set
British Columbia Cancer Agency- Centre for the Southern Interior, Kelowna, Not set
McGill University Health Center, Québec, Not set
Princess Margaret Hospital, Toronto, Not set
Cancer Care Manitoba, Winnipeg, Not set
Fundación Arturo López Pérez (FALP), Santiago, Not set
Centro de Investigacion Clinica Bradford Hill, Santiago, Not set
Oncocentro APYS, Viña Del Mar, Not set
Aalborg University Hospital, Aalborg, Not set
Service d'Oncologie Medicale - CHRU Besancon, Besançon, Not set
Institut Bergonie, Bordeaux Cedex, Not set
CHU Bordeaux - Hopital Saint-Andre, Bordeaux, Not set
Groupement de Cooperation Sanitaire (GCS) ELSAN - Clinique Victor Hugo, Le Mans, Not set
CHU de Limoges - Hopital Dupuytren 1, Limoges, Not set
Centre Leon Berard, Lyon, Not set
Institut Paoli-Calmettes, Marseille, Not set
ICM - Institut Regional du Cancer de Montpellier, Montpellier Cedex 5, Not set
Centre d'Oncologie de Gentilly, Nancy, Not set
Centre Antoine-Lacassagne, Nice, Not set
Institut Mutualiste Montsouris, Paris, Not set
AP-HP Hopital Europeen Georges Pompidou, Paris, Not set
HCL Centre Hospitalier Lyon Sud, Pierre-Benite Cedex, Not set
CHU Poitiers - Pole Regional de Cancerologie de Poitiers (PRC), Poitiers, Not set
Institut Gustave Roussy, Villejuif, Not set
LTD High Technology Hospital Medcenter, Batumi, Not set
The First University Clinic of Tbilisi State Medical University, Tbilisi, Not set
New Vision University Hospital, Tbilisi, Not set
Multiprofile Clinic Consilium Medulla LTD, Tbilisi, Not set
Universitaetsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Universitaetsklinikum Essen, Essen, Not set
Krankenhaus Nordwest GmbH, Frankfurt, Not set
Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe Universitaet, Frankfurt, Not set
Universitaetsklinikum Freiburg, Freiburg, Not set
Georg-August-Universitaet Goettingen Stiftung oeffentlichen Rechts Universitaetsmedizin Goettingen, Göttingen, Not set
Marien Hospital Herne - Universitaetsklinikum der Ruhr-Universitaet Bochum, Herne, Not set
Universitaetsmedizin Mannheim, Mannheim, Not set
Universitaetsklinikum Muenster, Münster, Not set
Studienpraxis Urologie, Nürtingen, Not set
Universitaetsklinikum Tuebingen, Tübingen, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Budapesti Uzsoki Utcai Korhaz, Budapest, Not set
Somogy Varmegyei Kaposi Mor Oktato Korhaz, Kaposvár, Not set
Bacs-Kiskun Varmegyei Oktatokorhaz, Kecskemét, Not set
Shamir Medical Center, Be'er Ya'aqov, Not set
Rambam Health Care Campus, Haifa, Not set
Hadassah Hebrew University Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Rabin Medical Center - Beilinson Hospital, Petach Tikva, Not set
Sourasky Medical Center, Tel Aviv, Not set
Centro Riferimento Oncologico - Aviano, Aviano, Not set
Ospedale Policlinico San Martino IRCCS, Genova, Not set
Istituto Europeo di Oncologia, Milano, Not set
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Napoli, Not set
Azienda Ospedaliera Santa Maria di Terni, Terni, Not set
Chungnam National University Hospital, Daejeon, Not set
National Cancer Center, Goyang, Not set
Chonnam National University Hwasun Hospital, Gwangju, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Copernicus PL Sp. z o.o., Wojewodzkie Centrum Onkologii, Gdańsk, Not set
Spitale Pomorskie Sp.z.o.o ODDZIAL ONKOLOGII KLINICZNEJ, Gdynia, Not set
SCM Sp. z o.o., Kraków, Not set
Mazowiecki Szpital Onkologiczny, Wieliszew, Not set
University Clinical Center of Serbia, Clinic of Urology, Belgrade, Not set
National University Hospital, Singapore, Not set
National Cancer Centre Singapore, Singapore, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Institut Catala d'Oncologia - L'Hospitalet, Barcelona, Not set
Hospital Universitario Insular de Gran Canaria, Las Palmas De Gran Canaria, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Clinica Universidad de Navarra - Madrid, Madrid, Not set
Hospital Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Clinica Universidad de Navarra - Pamplona, Pamplona, Not set
Hospital Universitario Donostia, San Sebastián, Not set
Hospital Universitario Marques de Valdecilla, Santander, Not set
Hospital Clinico Universitario de Santiago, Santiago De Compostela, Not set
Instituto Valenciano de Oncologia, Valencia, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
Chi Mei Medical Center, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital (CGMHLK), Taoyuan city, Not set
Liv Hospital Ankara, Ankara, Not set
Trakya University Medical Faculty, Edirne, Not set
Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Not set
Istinye Universitesi VM Medical Park Pendik Hastanesi, Istanbul, Not set
Medical Point Izmir Hospital, İzmir, Not set
Kocaeli University Faculty of Medicine, Kocaeli, Not set
Bristol Haematology and Oncology Centre, Bristol, Not set
Addenbrooke's Hospital, Cambridge, Not set
St. Bartholomew's Hospital, London, Not set
University College London Hospital, London, Not set
Royal Free London NHS Foundation Trust, London, Not set
Charing Cross Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Derriford Hospital, Plymouth, Not set
The Royal Marsden Hospital, Sutton, Not set
Conditions: Metastatic Urothelial Cancer
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors
Recruiting
A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL \[LN-144/LN-145 (lifileucel)\] in combination with immune checkpoint inhibitors or TIL \[LN-144/LN-145 (lifileucel) and LN-145-S1\] as a single agent therapy.
A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL \[LN-144/LN-145 (lifileucel)\] in combination with immune checkpoint inhibitors or TIL \[LN-144/LN-145 (lifileucel) and LN-145-S1\] as a single agent therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: University of California, San Diego, La Jolla, California +44 locations
University of California, San Diego, La Jolla, California
University of Southern California, Los Angeles, California
University of California, Los Angeles, Los Angeles, California
University of Colorado, Denver, Colorado
Yale University, New Haven, Connecticut
Georgetown University Medical Center, Washington, District of Columbia
Mount Sinai Medical Center, Miami Beach, Florida
Orlando Health Cancer Institute, Orlando, Florida
Moffitt Cancer Center, Tampa, Florida
University of Louisville, Louisville, Kentucky
University of Maryland, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health System, Detroit, Michigan
MD Anderson at Cooper, Camden, New Jersey
Morristown Medical Center, Morristown, New Jersey
Columbia University, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Cincinnati, Cincinnati, Ohio
Ohio State University, Columbus, Ohio
Avera Cancer Institute, Sioux Falls, South Dakota
Huntsman Cancer Hospital, Salt Lake City, Utah
Fred Hutchinson Cancer Research Center, Seattle, Washington
Medical College of Wisconsin, Milwaukee, Wisconsin
Princess Margaret Cancer Centre, Toronto, Ontario
Centre Léon Berard, Lyon, Not set
Klinikum rechts der Isar der Technischen Universität München, München, Bavaria
Universitätsklinikum Carl Gustav Carus, Dresden, Sachsen
Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck, Schleswig-Holstein
Laiko General Hospital of Athens, Athens, Attiki
Attikon University General Hospital, Athens, Attiki
Hospital Universitario Marques de Valdecilla, Santander, Cantabria
University Hospital Vall d'Hebron, Barcelona, Not set
ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario HM Sanchinarro, Madrid, Not set
Hospital Regional Universitario de Malaga - Hospital General, Málaga, Not set
Universitätsspital Basel, Basel, Not set
Universitaetsspital Bern, Bern, Not set
Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
Guy's Hospital, London, England
The Royal Marsden NHS Foundation Trust, London, England
Bristol Haematology and Oncology Centre, Bristol, Not set
Conditions: Metastatic Melanoma, Squamous Cell Carcinoma of the Head and Neck, Non-small Cell Lung Cancer
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
Active Not Recruiting
A Global Study to Determine the Efficacy and Safety of Durvalumab in Combination with Gemcitabine+Cisplatin for Neoadjuvant Treatment and Durvalumab Alone for Adjuvant Treatment in Patients with Muscle-Invasive Bladder Cancer
A Global Study to Determine the Efficacy and Safety of Durvalumab in Combination with Gemcitabine+Cisplatin for Neoadjuvant Treatment and Durvalumab Alone for Adjuvant Treatment in Patients with Muscle-Invasive Bladder Cancer Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
06/17/2025
Locations: Research Site, Birmingham, Alabama +187 locations
Research Site, Birmingham, Alabama
Research Site, Los Angeles, California
Research Site, Palo Alto, California
Research Site, New Haven, Connecticut
Research Site, Chicago, Illinois
Research Site, Geneva, Illinois
Research Site, Iowa City, Iowa
Research Site, Westwood, Kansas
Research Site, Louisville, Kentucky
Research Site, New Orleans, Louisiana
Research Site, Towson, Maryland
Research Site, Ann Arbor, Michigan
Research Site, Detroit, Michigan
Research Site, New York, New York
Research Site, Rochester, New York
Research Site, Bethlehem, Pennsylvania
Research Site, Burlington, Vermont
Research Site, Milwaukee, Wisconsin
Research Site, Brisbane, Not set
Research Site, Elizabeth Vale, Not set
Research Site, Macquarie University, Not set
Research Site, Melbourne, Not set
Research Site, Murdoch, Not set
Research Site, South Brisbane, Not set
Research Site, Brugge, Not set
Research Site, Charleroi, Not set
Research Site, Kortrijk, Not set
Research Site, Leuven, Not set
Research Site, Liège, Not set
Research Site, Roeselare, Not set
Research Site, Barretos, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Santa Maria, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, São José do Rio Preto, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Edmonton, Alberta
Research Site, Vancouver, British Columbia
Research Site, London, Ontario
Research Site, Ottawa, Ontario
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Sherbrooke, Quebec
Research Site, Antofagasta, Not set
Research Site, Puerto Montt, Not set
Research Site, Santiago, Not set
Research Site, Temuco, Not set
Research Site, Temuco, Not set
Research Site, Viña del Mar, Not set
Research Site, Brno, Not set
Research Site, Brno, Not set
Research Site, Hradec Kralove, Not set
Research Site, Olomouc, Not set
Research Site, Praha 2, Not set
Research Site, Praha 8, Not set
Research Site, Praha, Not set
Research Site, Angers Cedex 01, Not set
Research Site, Dijon, Not set
Research Site, Grenoble Cedex 09, Not set
Research Site, Montpellier, Not set
Research Site, Nimes, Not set
Research Site, Pierre Benite, Not set
Research Site, Poitiers Cedex, Not set
Research Site, Rouen, Not set
Research Site, Bergisch Gladbach, Not set
Research Site, Bonn, Not set
Research Site, Erlangen, Not set
Research Site, Göttingen, Not set
Research Site, Herne, Not set
Research Site, Jena, Not set
Research Site, Köln, Not set
Research Site, Magdeburg, Not set
Research Site, Mannheim, Not set
Research Site, Münster, Not set
Research Site, Nürnberg, Not set
Research Site, Oldenburg, Not set
Research Site, Regensburg, Not set
Research Site, Ulm, Not set
Research Site, Würzburg, Not set
Research Site, Haifa, Not set
Research Site, Jerusalem, Not set
Research Site, Kfar Saba, Not set
Research Site, Petach-Tikva, Not set
Research Site, Ramat Gan, Not set
Research Site, Bari, Not set
Research Site, Bologna, Not set
Research Site, Firenze, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Napoli, Not set
Research Site, Orbassano, Not set
Research Site, Pozzuoli, Not set
Research Site, Verona, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Fukuoka, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Kanazawa-shi, Not set
Research Site, Koto-ku, Not set
Research Site, Kumamoto-shi, Not set
Research Site, Miyazaki-city, Not set
Research Site, Nagasaki-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Niigata-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Toyama-shi, Not set
Research Site, Tsukuba-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Daegu, Not set
Research Site, Goyang-si, Not set
Research Site, Gyeonggi-do, Not set
Research Site, Incheon, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Amsterdam, Not set
Research Site, Amsterdam, Not set
Research Site, Breda, Not set
Research Site, Rotterdam, Not set
Research Site, Baguio City, Not set
Research Site, Cebu, Not set
Research Site, Davao City, Not set
Research Site, Makati, Not set
Research Site, Manila, Not set
Research Site, Quezon City, Not set
Research Site, Quezon City, Not set
Research Site, Bialystok, Not set
Research Site, Gdańsk, Not set
Research Site, Grudziądz, Not set
Research Site, Koszalin, Not set
Research Site, Kraków, Not set
Research Site, Olsztyn, Not set
Research Site, Ostrołęka, Not set
Research Site, Poznan, Not set
Research Site, Warszawa, Not set
Research Site, Wroclaw, Not set
Research Site, Krasnoyarsk, Not set
Research Site, Moscow, Not set
Research Site, Nizhniy Novgorod, Not set
Research Site, Novosibirsk, Not set
Research Site, Samara, Not set
Research Site, St Petersburg, Not set
Research Site, St. Petersburg, Not set
Research Site, St. Petersburg, Not set
Research Site, St. Petersburg, Not set
Research Site, Ufa, Not set
Research Site, Vologda, Not set
Research Site, Badalona, Not set
Research Site, Barcelona, Not set
Research Site, Córdoba, Not set
Research Site, Las Palmas de Gran Canaria, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Santander, Not set
Research Site, Sevilla, Not set
Research Site, Kaohsiung, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Tainan, Not set
Research Site, Tainan, Not set
Research Site, Taipei City, Not set
Research Site, Taipei, Not set
Research Site, Taoyuan City, Not set
Research Site, Ankara, Not set
Research Site, Edirne, Not set
Research Site, Istanbul, Not set
Research Site, İstanbul, Not set
Research Site, Izmir, Not set
Research Site, Karsiyaka, Not set
Research Site, Edinburgh, Not set
Research Site, London, Not set
Research Site, Nottingham, Not set
Research Site, Sheffield, Not set
Research Site, Wirral, Not set
Research Site, Hanoi, Not set
Research Site, Ho Chi Minh, Not set
Research Site, Hochiminh, Not set
Conditions: Muscle Invasive Bladder Cancer
49 - 60 of 298