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Cisplatin Treatment Options in United Kingdom
A collection of 298 research studies where Cisplatin is the interventional treatment. These studies are located in the United Kingdom . Cisplatin is used for conditions such as Head and Neck Cancer, Lung Cancer and Non-Small Cell Lung Cancer.
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Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
Active Not Recruiting
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy + Standard of care (SoC) chemotherapy or durvalumab monotherapy + SoC chemotherapy versus SoC chemotherapy alone as first line treatment in patients with metastatic non small-cell lung cancer (NSCLC) with tumors that lack activating epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) fusions.
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy + Standard of care (SoC) chemotherapy or durvalumab monotherapy + SoC chemotherapy versus SoC chemotherapy alone as first line treatment in patients with metastatic non small-cell lung cancer (NSCLC) with tumors that lack activating epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) fusions. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
06/11/2025
Locations: Research Site, Phoenix, Arizona +174 locations
Research Site, Phoenix, Arizona
Research Site, Bakersfield, California
Research Site, Santa Monica, California
Research Site, Fort Myers, Florida
Research Site, Jacksonville, Florida
Research Site, Saint Petersburg, Florida
Research Site, West Palm Beach, Florida
Research Site, Louisville, Kentucky
Research Site, Kansas City, Missouri
Research Site, Canton, Ohio
Research Site, Pittsburgh, Pennsylvania
Research Site, Chattanooga, Tennessee
Research Site, Nashville, Tennessee
Research Site, Fort Worth, Texas
Research Site, Houston, Texas
Research Site, Richmond, Virginia
Research Site, Barretos, Not set
Research Site, Belo Horizonte, Not set
Research Site, Curitiba, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Ribeirao Preto, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Santo Andre, Not set
Research Site, Santo André, Not set
Research Site, Sao Paulo, Not set
Research Site, São José do Rio Preto, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Plovdiv, Not set
Research Site, Plovdiv, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Varna, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Fuzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Hefei, Not set
Research Site, Kunming, Not set
Research Site, Linyi, Not set
Research Site, Liuzhou, Not set
Research Site, Nanjing, Not set
Research Site, Qingdao, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shantou, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Xining, Not set
Research Site, Yangzhou, Not set
Research Site, Zhanjiang, Not set
Research Site, Zhengzhou, Not set
Research Site, Zhengzhou, Not set
Research Site, Berlin, Not set
Research Site, Essen, Not set
Research Site, Freiburg, Not set
Research Site, Gauting, Not set
Research Site, Hamburg, Not set
Research Site, Hamburg, Not set
Research Site, Heidelberg, Not set
Research Site, Immenhausen, Not set
Research Site, Mainz, Not set
Research Site, Oldenburg, Not set
Research Site, Würzburg, Not set
Research Site, Shatin, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Kecskemét, Not set
Research Site, Miskolc, Not set
Research Site, Törökbálint, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Chuo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Iwakuni-shi, Not set
Research Site, Kanazawa, Not set
Research Site, Kashiwa, Not set
Research Site, Koto-ku, Not set
Research Site, Kurume-shi, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osakasayama, Not set
Research Site, Sapporo-shi, Not set
Research Site, Sunto-gun, Not set
Research Site, Toyoake-shi, Not set
Research Site, Ube-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Busan, Not set
Research Site, Chungcheongbuk-do, Not set
Research Site, Daegu, Not set
Research Site, Incheon, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Ulsan, Not set
Research Site, Aguascalientes, Not set
Research Site, Cuautitlan Izcalli, Not set
Research Site, Guadalajara, Not set
Research Site, Mexico City, Not set
Research Site, Mexico, Not set
Research Site, Monterrey, Not set
Research Site, Monterrey, Not set
Research Site, México, Not set
Research Site, Tuxtla, Not set
Research Site, Arequipa, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, San Isidro, Not set
Research Site, Olsztyn, Not set
Research Site, Tomaszów Mazowiecki, Not set
Research Site, Warszawa, Not set
Research Site, Wodzisław Śląski, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Omsk, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint-Petersburg, Not set
Research Site, Sankt-Peterburg, Not set
Research Site, St. Petersburg, Not set
Research Site, Cape Town, Not set
Research Site, Durban, Not set
Research Site, Johannesburg, Not set
Research Site, Parktown, Not set
Research Site, Pretoria, Not set
Research Site, Rondebosch, Not set
Research Site, Vereeniging, Not set
Research Site, Changhua City, Not set
Research Site, Kaohsiung City, Not set
Research Site, Kaohsiung, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Tainan, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Tao-Yuan, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Muang, Not set
Research Site, Songkhla, Not set
Research Site, Dnipro, Not set
Research Site, Ivano-Frankivsk, Not set
Research Site, Kirovohrad, Not set
Research Site, Kyiv, Not set
Research Site, Kyiv, Not set
Research Site, Lviv, Not set
Research Site, Odesa, Not set
Research Site, Sumy, Not set
Research Site, Vinnytsia, Not set
Research Site, Zaporizhzhia, Not set
Research Site, Leicester, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Hanoi, Not set
Research Site, Ho Chi Minh, Not set
Conditions: Non Small Cell Lung Cancer NSCLC
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
Active Not Recruiting
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy versus platinum-based SoC chemotherapy in the first-line treatment of patients with epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type advanced or metastatic NSCLC.
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy versus platinum-based SoC chemotherapy in the first-line treatment of patients with epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type advanced or metastatic NSCLC. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
06/06/2025
Locations: Research Site, Anaheim, California +210 locations
Research Site, Anaheim, California
Research Site, San Diego, California
Research Site, Santa Rosa, California
Research Site, Louisville, Kentucky
Research Site, Florham Park, New Jersey
Research Site, Albuquerque, New Mexico
Research Site, East Setauket, New York
Research Site, Fresh Meadows, New York
Research Site, Poughkeepsie, New York
Research Site, Stony Brook, New York
Research Site, Canton, Ohio
Research Site, Columbus, Ohio
Research Site, Zanesville, Ohio
Research Site, Pittsburgh, Pennsylvania
Research Site, Houston, Texas
Research Site, Berazategui, Not set
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, Córdoba, Not set
Research Site, La Rioja, Not set
Research Site, Rosario, Not set
Research Site, San Salvador de Jujuy, Not set
Research Site, Santa Rosa, Not set
Research Site, Barretos, Not set
Research Site, Belo Horizonte, Not set
Research Site, Belo Horizonte, Not set
Research Site, Fortaleza, Not set
Research Site, Ijui, Not set
Research Site, Itajai, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, São José do Rio Preto, Not set
Research Site, São Paulo, Not set
Research Site, Plovdiv, Not set
Research Site, Shumen, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Sofia, Not set
Research Site, Varna, Not set
Research Site, Vratza, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Temuco, Not set
Research Site, Viña del Mar, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Urumqi, Not set
Research Site, Wuhan, Not set
Research Site, Wuhan, Not set
Research Site, Odense C, Not set
Research Site, Oulu, Not set
Research Site, Tampere, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Heraklion, Not set
Research Site, Holargos, Athens, Not set
Research Site, Ioannina, Not set
Research Site, Hong Kong, Not set
Research Site, King's Park, Not set
Research Site, Shatin, Not set
Research Site, Ahmedabad, Not set
Research Site, Bangalore, Not set
Research Site, Bangalore, Not set
Research Site, Chennai, Not set
Research Site, Gurgaon, Not set
Research Site, Karamsad, Not set
Research Site, New Delhi, Not set
Research Site, Beer Sheva, Not set
Research Site, Jerusalem, Not set
Research Site, Kfar Saba, Not set
Research Site, Nahariya, Not set
Research Site, Petah Tikva, Not set
Research Site, Ramat Gan, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Fukushima-shi, Not set
Research Site, Habikino-shi, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Iizuka-shi, Not set
Research Site, Iwakuni-shi, Not set
Research Site, Kanazawa, Not set
Research Site, Kishiwada-shi, Not set
Research Site, Kobe-shi, Not set
Research Site, Kurume-shi, Not set
Research Site, Kyoto-shi, Not set
Research Site, Mitaka-shi, Not set
Research Site, Nagaoka-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Niigata-shi, Not set
Research Site, Okayama-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Saga-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sakai-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Tokushima-shi, Not set
Research Site, Ube-shi, Not set
Research Site, Wakayama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Daegu, Not set
Research Site, Hwasun-gun, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Kuantan, Not set
Research Site, Kuching, Not set
Research Site, Acapulco, Not set
Research Site, Aguascalientes, Not set
Research Site, Mexico, Not set
Research Site, Monterrey, Not set
Research Site, Mérida, Not set
Research Site, México, Not set
Research Site, Arequipa, Not set
Research Site, Bellavista, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Baguio City, Not set
Research Site, Cebu, Not set
Research Site, Las Pinas City, Not set
Research Site, Manila, Not set
Research Site, Manila, Not set
Research Site, Quezon City, Not set
Research Site, Bydgoszcz, Not set
Research Site, Kielce, Not set
Research Site, Kraków, Not set
Research Site, Mrozy, Not set
Research Site, Olsztyn, Not set
Research Site, Poznan, Not set
Research Site, Poznań, Not set
Research Site, Warszawa, Not set
Research Site, Warszawa, Not set
Research Site, Wodzisław Śląski, Not set
Research Site, Łódź, Not set
Research Site, Amadora, Not set
Research Site, Lisboa, Not set
Research Site, Porto, Not set
Research Site, Porto, Not set
Research Site, Porto, Not set
Research Site, Doha, Not set
Research Site, Suceava, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Omsk, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint-Petersburg, Not set
Research Site, Saint-Petersburg, Not set
Research Site, St. Petersburg, Not set
Research Site, Dammam, Not set
Research Site, Riyadh, Not set
Research Site, Riyadh, Not set
Research Site, Singapore, Not set
Research Site, Singapore, Not set
Research Site, Singapore, Not set
Research Site, Singapore, Not set
Research Site, Eskilstuna, Not set
Research Site, Linköping, Not set
Research Site, Stockholm, Not set
Research Site, Uppsala, Not set
Research Site, Adana, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Izmir, Not set
Research Site, Chernivtsі, Not set
Research Site, Dnipro, Not set
Research Site, Ivano-Frankivsk, Not set
Research Site, Kapitanivka Village, Not set
Research Site, Kharkiv Region, Not set
Research Site, Kirovohrad, Not set
Research Site, Kyiv, Not set
Research Site, Kyiv, Not set
Research Site, Lviv, Not set
Research Site, Lyutizh, Not set
Research Site, Odesa, Not set
Research Site, Sumy, Not set
Research Site, Uzhhorod, Not set
Research Site, Vinnytsia, Not set
Research Site, Guildford, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Nottingham, Not set
Research Site, Taunton, Not set
Research Site, Wirral, Not set
Research Site, Wolverhampton, Not set
Conditions: Non Small Cell Lung Carcinoma NSCLC
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
Active Not Recruiting
The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary hypotheses are that pembrolizumab + adjuvant chemotherapy is superior to placebo + adjuvant chemotherapy, with or without radiotherapy, wi... Read More
The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary hypotheses are that pembrolizumab + adjuvant chemotherapy is superior to placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to DFS as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to OS. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/05/2025
Locations: University of Alabama - Birmingham ( Site 3061), Birmingham, Alabama +230 locations
University of Alabama - Birmingham ( Site 3061), Birmingham, Alabama
University of South Alabama, Mitchell Cancer Institute ( Site 3058), Mobile, Alabama
HonorHealth Research Institute - Biltmore ( Site 3043), Phoenix, Arizona
Arizona Oncology Associates PC- HOPE ( Site 3049), Tucson, Arizona
UCSD Moores Cancer Center ( Site 3053), La Jolla, California
University Of Colorado ( Site 3051), Aurora, Colorado
Smilow Cancer Hospital at Yale New Haven ( Site 3070), New Haven, Connecticut
Mount Sinai Cancer Center ( Site 3081), Miami Beach, Florida
Northside Hospital ( Site 3036), Atlanta, Georgia
Northwestern Memorial Hospital ( Site 3044), Chicago, Illinois
Parkview Cancer Institute ( Site 3067), Fort Wayne, Indiana
Indiana University Melvin and Bren Simon Cancer Center ( Site 3071), Indianapolis, Indiana
University of Iowa Hospital and Clinics ( Site 3046), Iowa City, Iowa
Norton Cancer Institute - St. Matthews ( Site 3056), Louisville, Kentucky
WK Physicians Network/Gynecologic Oncology Associates ( Site 3047), Shreveport, Louisiana
University of Massachusetts Medical School ( Site 3037), Worcester, Massachusetts
Montefiore Medical Center ( Site 3065), Bronx, New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 3076), Mineola, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 3042), New York, New York
Duke Cancer Center ( Site 3072), Durham, North Carolina
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 3080), Fargo, North Dakota
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C, Columbus, Ohio
Legacy Good Samaritan Medical Center ( Site 3033), Portland, Oregon
Sidney Kimmel Cancer Center - Jefferson Health ( Site 3078), Philadelphia, Pennsylvania
AHN West Penn Hospital ( Site 3060), Pittsburgh, Pennsylvania
Abington Hospital - Asplundh Cancer Center ( Site 3073), Willow Grove, Pennsylvania
Sanford Gynecology Oncology ( Site 3045), Sioux Falls, South Dakota
UT Southwestern Medical Center ( Site 3063), Dallas, Texas
VCU Massey Cancer Center ( Site 3068), Richmond, Virginia
Centro de Oncología e Investigación de Buenos Aires ( Site 1005), Berazategui, Buenos Aires
IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 1006), Caba, Buenos Aires
Instituto de Investigaciones Clinicas Mar del Plata ( Site 1003), Mar del Plata, Buenos Aires
Hospital Britanico de Buenos Aires ( Site 1002), Buenos Aires, Caba
Instituto de Oncologia de Rosario ( Site 1004), Rosario, Santa Fe
IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas ( Site 1010), Buenos Aires, Not set
Hospital Aleman ( Site 1001), Buenos Aires, Not set
CEMIC ( Site 1009), Buenos Aires, Not set
Centro Oncologico Riojano Integral ( Site 1007), La Rioja, Not set
Medizinische Universitat Graz ( Site 2004), Graz, Steiermark
Medizinische Universitaet Innsbruck ( Site 2001), Innsbruck, Tirol
Saint-Luc UCL ( Site 2042), Bruxelles, Bruxelles-Capitale, Region De
C.I.U. Hopital Ambroise Pare ( Site 2039), Mons, Hainaut
CHR Verviers ( Site 2035), Verviers, Liege
OLV Ziekenhuis ( Site 2038), Aalst, Oost-Vlaanderen
AZ Maria Middelares Gent ( Site 2032), Gent, Oost-Vlaanderen
Universitair Ziekenhuis Gent ( Site 2037), Gent, Oost-Vlaanderen
AZ Nikolaas ( Site 2031), Sint-Niklaas, Oost-Vlaanderen
UZ Leuven ( Site 2040), Leuven, Vlaams-Brabant
AZ Groeninge ( Site 2036), Kortrijk, West-Vlaanderen
CHC - Groupe Sante ( Site 2041), Liege, Not set
CHU Liege Sart-Tilman ( Site 2044), Liege, Not set
Tom Baker Cancer Centre ( Site 3007), Calgary, Alberta
Kingston Health Sciences Centre ( Site 3003), Kingston, Ontario
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 3006), Montreal, Quebec
McGill University Health Centre ( Site 3005), Montreal, Quebec
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 3, Quebec City, Quebec
Centro Investigación del Cáncer James Lind ( Site 1061), Temuco, Araucania
Fundacion Arturo Lopez Perez FALP ( Site 1062), Santiago, Region M. De Santiago
Centro de Cancer Nuestra Senora de la Esperanza ( Site 1063), Santiago, Region M. De Santiago
Bradfordhill-Clinical Area ( Site 1070), Santiago, Region M. De Santiago
Oncocentro ( Site 1065), Vina del Mar, Valparaiso
Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 4034), Hefei, Anhui
Beijing Cancer Hospital ( Site 4048), Beijing, Beijing
Peking Union Medical College Hospital ( Site 4036), Beijing, Beijing
Chongqing Cancer Hospital ( Site 4040), Chongqing, Chongqing
The First Affiliated Hospital of Xiamen University ( Site 4060), Xiamen, Fujian
The First Affiliated Hospital ( Site 4043), Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital ( Site 4049), Nanning, Guangxi
Harbin Medical University Cancer Hospital ( Site 4033), Harbin, Heilongjiang
Hubei Cancer Hospital ( Site 4059), Wuhan, Hubei
Xiangya Hospital Central-South University ( Site 4035), Changsha, Hunan
Hunan Cancer Hospital ( Site 4050), Changsha, Hunan
Nanjing Drum Tower Hospital ( Site 4037), Nanjing, Jiangsu
Jiangxi Maternal and Child Health Hospital ( Site 4051), Nanchang, Jiangxi
The First Bethune Hospital of Jilin University ( Site 4057), Changchun, Jilin
The First Affiliated Hospital of Xi an Jiaotong University ( Site 4045), XI An, Shaanxi
Obstetrics and Gynecology Hosp. Fudan University ( Site 4041), Shanghai, Shanghai
Shanghai Renji Hospital Affiliated to Jiao Tong University ( Site 4053), Shanghai, Shanghai
Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 4001), Shanghai, Shanghai
Sichuan Cancer Hospital ( Site 4039), Chengdu, Sichuan
Tianjin Medical University Cancer Institute & Hospital ( Site 4054), Tianjin, Tianjin
Yunnan Province Cancer Hospital-Gynecology Department ( Site 4055), Kunming, Yunnan
The First Affiliated Hospital, Zhejiang University-Gynecology ( Site 4002), Hangzhou, Zhejiang
Women s Hospital School of Medicine Zhejiang University ( Site 4032), Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University ( Site 4056), Wenzhou, Zhejiang
Clínica Vida Fundación - Sede Poblado ( Site 1096), Medellin, Antioquia
Instituto Nacional de Cancerología E.S.E ( Site 1094), Bogota, Distrito Capital De Bogota
Instituto Cancerologico de Narino Ltda ( Site 1092), San Juan De Pasto, Narino
Fundacion Valle del Lili ( Site 1093), Cali, Valle Del Cauca
Fakultní nemocnice Brno Bohunice-Gynekologicko-porodnicka klinika ( Site 2394), Brno, Brno-mesto
Fakultni nemocnice Kralovske Vinohrady ( Site 2393), Praha, Praha 10
Vseobecna fakultni nemocnice v Praze ( Site 2391), Praha, Praha 2
Fakultni nemocnice Olomouc ( Site 2392), Olomouc, Not set
Rigshospitalet University Hospital ( Site 2515), Copehagen, Hovedstaden
Herlev Hospital ( Site 2514), Herlev, Hovedstaden
Aalborg Universitetshospital ( Site 2511), Aalborg, Nordjylland
Roskilde Sygehus ( Site 2513), Roskilde, Sjaelland
Odense Universitetshospital ( Site 2512), Odense, Syddanmark
Tampere University Hospital ( Site 2541), Tampere, Pirkanmaa
Kuopio University Hospital ( Site 2543), Kuopio, Pohjois-Savo
Turku University Hospital ( Site 2542), Turku, Varsinais-Suomi
Institut De Cancerologie De Lorraine ( Site 2072), Vandoeuvre les Nancy, Ain
Centre Antoine Lacassagne ( Site 2073), Nice, Alpes-Maritimes
Centre Francois Baclesse ( Site 2062), Caen, Calvados
Hôpital Privé Des Côtes d'Armor ( Site 2063), Plérin, Cotes-d Armor
CHU Besancon - Hopital Jean Minjoz ( Site 2068), Besancon, Doubs
Institut Bergonie ( Site 2067), Bordeaux, Gironde
Institut Universitaire du Cancer Toulouse - Oncopole ( Site 2065), Toulouse, Haute-Garonne
Institut Regional du Cancer de Montpellier - ICM ( Site 2069), Montpellier, Herault
Hopital Cochin ( Site 2070), Paris, Ile-de-France
Gustave Roussy ( Site 2071), Villejuif, Ile-de-France
Hopital prive du Confluent ( Site 2061), Nantes, Loire-Atlantique
Centre Hospitalier Lyon Sud ( Site 2064), Pierre Benite, Rhone
SLK-Kliniken Heilbronn GmbH ( Site 2116), Heilbronn, Baden-Wurttemberg
Klinikum Ludwigsburg ( Site 2111), Ludwigsburg, Baden-Wurttemberg
Universitaetsklinikum Tuebingen ( Site 2113), Tübingen, Baden-Wurttemberg
Medizinische Hochschule Hannover-Department of Obstetrics and Gynecology ( Site 2109), Hannover, Niedersachsen
Universitätsklinikum Bonn-Gynaecological oncology ( Site 2103), Bonn, Nordrhein-Westfalen
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 2105), Essen, Nordrhein-Westfalen
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur, Dresden, Sachsen
Universitätsklinikum Schleswig-Holstein ( Site 2101), Lübeck, Schleswig-Holstein
General Hospital of Patras. St Andrews ( Site 2421), Patras, Achaia
Geniko Panepistimako Nosokomeio ARETEIO ( Site 2423), Athens, Attiki
Perifereiako Geniko Nosokomeio ALEXANDRA ( Site 2425), Athens, Attiki
Athens University Hospital ATTIKON ( Site 2424), Chaidari, Attiki
Hospital Hygeia ( Site 2426), Marousi, Attiki
Euromedica General Clinic of Thessaloniki ( Site 2422), Thessaloniki, Not set
Rambam Medical Center ( Site 2307), Haifa, Not set
Edith Wolfson Medical Center ( Site 2306), Holon, Not set
Hadassah Medical Center. Ein Kerem ( Site 2303), Jerusalem, Not set
Rabin Medical Center ( Site 2305), Petah Tikva, Not set
Chaim Sheba Medical Center ( Site 2301), Ramat Gan, Not set
Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 2121), Roma, Abruzzo
Fondazione Policlinico Universitario Agostino Gemelli ( Site 2124), Roma, Lazio
Istituto di Candiolo - IRCCS ( Site 2125), Candiolo, Piemonte
Azienda Ospedaliera Spedali Civili di Brescia ( Site 2135), Brescia, Not set
IRCCS Ospedale San Raffaele ( Site 2130), Milano, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2122), Milano, Not set
Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 2132), Milano, Not set
Azienda Ospedaliera Universitaria Federico II ( Site 2123), Napoli, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2127), Napoli, Not set
Istituto Oncologico Veneto IRCCS-Oncologia 2 ( Site 2134), Padova, Not set
Aichi Cancer Center Hospital ( Site 4190), Nagoya, Aichi
National Cancer Center Hospital East ( Site 4197), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 4181), Matsuyama, Ehime
Ehime University Hospital ( Site 4187), Toon, Ehime
Kurume University Hospital ( Site 4186), Kurume, Fukuoka
Gunma Prefectural Cancer Center ( Site 4183), Ota, Gunma
Hokkaido University Hospital ( Site 4194), Sapporo, Hokkaido
Hyogo Cancer Center ( Site 4195), Akashi, Hyogo
Iwate Medical University Hospital ( Site 4189), Shiwa-gun, Iwate
University of the Ryukyus Hospital ( Site 4184), Nakagami-gun, Okinawa
Saitama Medical University International Medical Center ( Site 4182), Hidaka, Saitama
Shizuoka Cancer Center Hospital and Research Institute ( Site 4192), Sunto-gun, Shizuoka
National Hospital Organization Kyushu Cancer Center ( Site 4193), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 4185), Niigata, Not set
Osaka International Cancer Institute ( Site 4188), Osaka, Not set
The Cancer Institute Hospital of JFCR ( Site 4196), Tokyo, Not set
Keio University Hospital ( Site 4191), Tokyo, Not set
National Cancer Center ( Site 4065), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 4063), Seongnam-si, Kyonggi-do
Severance Hospital Yonsei University Health System ( Site 4062), Seoul, Not set
Asan Medical Center ( Site 4061), Seoul, Not set
Samsung Medical Center ( Site 4064), Seoul, Not set
Investigacion Onco Farmaceutica S de RL de CV ( Site 1127), La Paz, Baja California Sur
Hospital San Lucas Cardiologica del Sureste ( Site 1122), Tuxtla Gutierrez, Chiapas
Instituto Nacional de Cancerologia ( Site 1124), Cdmx, Distrito Federal
Christus Muguerza Clinica Vidriera ( Site 1125), Monterrey, Nuevo Leon
I Can Oncology Center SA de CV ( Site 1126), Monterrey, Nuevo Leon
Hospital Angeles Roma ( Site 1123), Ciudad de Mexico, Not set
Centro Oncologico Internacional. SEDNA ( Site 1121), Mexico City, Not set
University Hospital of North Norway ( Site 2153), Tromso, Troms
Soerlandet sykehus HF Kristiansand ( Site 2152), Kristiansand, Vest-Agder
Oslo Universitetssykehus Radiumhospitalet ( Site 2151), Oslo, Not set
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2487), Siedlce, Mazowieckie
Szpital Kliniczny im Ks Anny Mazowieckiej ( Site 2481), Warszawa, Mazowieckie
Bialostockie Centrum Onkologii ( Site 2483), Bialystok, Podlaskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2482), Gliwice, Slaskie
Swietokrzyskie Centrum Onkologii SPZOZ ( Site 2485), Kielce, Swietokrzyskie
SPZOZ MSWIA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie ( Site 2486), Olsztyn, Warminsko-mazurskie
Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 2484), Poznan, Wielkopolskie
Arkhangelsk Clinical Oncological Dispensary ( Site 2637), Arkhangelsk, Arkhangel Skaya Oblast
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 2645), Ufa, Baskortostan, Respublika
Chelyabinsk Regional Clinical Center Oncology and Nuclear Medicine ( Site 2644), Chelyabinsk, Chelyabinskaya Oblast
Krasnoyarsk Regional Clinical oncology dispensary ( Site 2643), Krasnoyarsk, Krasnoyarskiy Kray
National Research Ogarev Mordovia State University ( Site 2648), Saransk, Mordoviya, Respublika
FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 2634), Moscow, Moskva
Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2631), Moscow, Moskva
Nizhegorodsky Regional Oncology Dispensary-chemotherapy department (Branch№1) ( Site 2639), Nizhniy Novgorod, Nizhegorodskaya Oblast
Samara Regional Clinical Oncology Center-Chemotherapy Dapartment ( Site 2649), Samara, Samarskaya Oblast
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2636), Saint-Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2646), Kazan, Tatarstan, Respublika
Tomsk Scientific Research Institute of Oncology-Chemotherapy ( Site 2638), Tomsk, Tomskaya Oblast
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 2641), Yaroslavl, Yaroslavskaya Oblast
Hospital Josep Trueta ( Site 2184), Girona, Gerona
Clinica Universitaria de Navarra ( Site 2181), Madrid, Madrid, Comunidad De
Hospital Vall D Hebron ( Site 2182), Barcelona, Not set
Hospital Clinic i Provincial ( Site 2185), Barcelona, Not set
Hospital Universitario Reina Sofia ( Site 2183), Cordoba, Not set
Hospital Clinico San Carlos ( Site 2187), Madrid, Not set
Hospital Universitario La Paz ( Site 2186), Madrid, Not set
Universitetssjukhuset i Linkoping. ( Site 2222), Linkoping, Ostergotlands Lan
Karolinska Universitetssjukhuset Solna ( Site 2220), Solna, Stockholms Lan
Blod-och Tumorsjukdomar ( Site 2221), Uppsala, Uppsala Lan
Changhua Christian Hospital ( Site 4095), Changhua, Not set
Taichung Veterans General Hospital ( Site 4094), Taichung, Not set
MacKay Memorial Hospital ( Site 4092), Taipei, Not set
Taipei Veterans General Hospital ( Site 4093), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 4091), Taoyuan, Not set
Baskent Adana Dr Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 2355), Adana, Not set
Cukurova Uni. Tip Fakultesi ( Site 2353), Adana, Not set
Baskent Universitesi Ankara Hastanesi ( Site 2354), Ankara, Not set
Ankara Universitesi Tıp Fakultesi Hastanesi ( Site 2350), Ankara, Not set
Medipol Universite Hastanesi ( Site 2352), Istanbul, Not set
Ege University Medical Faculty ( Site 2351), Izmir, Not set
I.E.U. Medical Point Hastanesi ( Site 2356), Izmir, Not set
Chernihiv Medical Center of Modern Oncology ( Site 2368), Chernihiv, Chernihivska Oblast
Municipal Enterprise "Bukovinian сlinical oncology сenter" ( Site 2366), Chernivtsi, Chernivetska Oblast
SO Grigoriev Institute for Medical Radiology and Oncology of NAMS of Ukraine ( Site 2363), Kharkiv, Kharkivska Oblast
MNE "Khmelnytskyi regional antitumor center" ( Site 2365), Khmelnitskyi, Khmelnytska Oblast
LISOD - Israeli Oncological Hospital MedX-ray International Group, LLC ( Site 2364), Kiev, Kyivska Oblast
Lviv State Regional Oncological Center ( Site 2361), Lviv, Lvivska Oblast
The Municipal Enterprise Volyn Regional Medical Oncology Centre ( Site 2362), Lutsk, Volynska Oblast
Bristol Haematology and Oncology Centre ( Site 2244), Bristol, Bristol, City Of
Castle Hill Hospital-Academic Oncology ( Site 2252), Cottingham, East Riding Of Yorkshire
Beatson West of Scotland Cancer Centre ( Site 2247), Glasgow, Glasgow City
UCLH NHS Foundation Trust ( Site 2242), London, London, City Of
Royal Marsden NHS Foundation Trust ( Site 2248), London, London, City Of
Royal Marsden Hospital Sutton-Surrey ( Site 2241), Sutton, London, City Of
Leicester Royal Infirmary. Univ. Hosp. of Leicester NHS Trust ( Site 2249), Leicester, Not set
The Christie Hospital NHS Foundation Trust ( Site 2243), Manchester, Not set
Conditions: Endometrial Neoplasms
A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer
Active Not Recruiting
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC).
Eligible participants will be randomized in a 1:1 ratio to receive one of t... Read More
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC).
Eligible participants will be randomized in a 1:1 ratio to receive one of the following treatment regimens during the induction phase:
* Arm A: Tiragolumab plus atezolizumab plus pemetrexed and carboplatin or cisplatin
* Arm B: Placebo plus pembrolizumab plus pemetrexed and carboplatin or cisplatin
Following the induction phase, participants will continue maintenance therapy with either tiragolumab in combination with atezolizumab and pemetrexed (Arm A) or placebo in combination with pembrolizumab and pemetrexed (Arm B). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: UCLA, Los Angeles, California +121 locations
UCLA, Los Angeles, California
Torrance Memorial Physician Network/Cancer Care, Torrance, California
PIH Health Whittier Hospital, Whittier, California
SCRI Florida Cancer Specialists South, Fort Myers, Florida
SCRI Florida Cancer Specialists North, Saint Petersburg, Florida
Advent Health Orlando, Winter Park, Florida
Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia
Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne, Indiana
Baptist Health Lexington, Lexington, Kentucky
Tennessee Oncology Chattanooga, Chattanooga, Tennessee
Sarah Cannon Research Institute / Tennessee Oncology, Nashville, Tennessee
Inova Schar Cancer Institute, Fairfax, Virginia
AZORG Campus Aalst-Moorselbaan, Aalst, Not set
Cliniques Universitaires St-Luc, Bruxelles, Not set
CHU UCL Mont-Godinne, Mont-godinne, Not set
Vitaz, Sint Niklaas, Not set
Crio - Centro Regional Integrado de Oncologia, Fortaleza, Ceará
Oncocentro Belo Horizonte, Belo Horizonte, Minas Gerais
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, Rio Grande Do Sul
Hospital das Clinicas - UFRGS, Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceicao, Porto Alegre, Rio Grande Do Sul
Hospital de Cancer de Barretos, Barretos, São Paulo
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, São Paulo
Cross Cancer Institute, Edmonton, Alberta
Royal Victoria Regional Health Centre, Barrie, Ontario
Lakeridge Health Oshawa, Oshawa, Ontario
Sault Area Hospital, Sault Ste. Marie, Ontario
Beijing Cancer Hospital, Beijing, Not set
Jilin Cancer Hospital, Changchun, Not set
Xiangya Hospital Central South University, Changsha City, Not set
Changzhou First People's Hospital, Changzhou, Not set
Affiliated Hospital of Chengde Medical University, Chengde City, Not set
Sichuan Cancer Hospital, Chengdu City, Not set
West China Hospital - Sichuan University, Chengdu City, Not set
Anhui Provincial Hospital, Hefei, Not set
Jinan Central Hospital, Jinan City, Not set
Pingxiang People Hospital, Pingxiang City, Not set
Qingdao Central Hospital, Qingdao City, Not set
Weifang People's Hospital, Weifang City, Not set
Hubei Cancer Hospital, Wuhan, Not set
The First Affiliated Hospital of Xian Jiao Tong University, Xi'an City, Not set
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang City, Not set
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Not set
Rigshospitalet, København Ø, Not set
Odense Universitetshospital, Onkologisk Afdeling R, Odense C, Not set
Sjællands Universitetshospital, Roskilde, Roskilde, Not set
Institut Bergonie, Bordeaux, Not set
Hopital Nord, Marseille cedex 20, Not set
Hopital de Pontchaillou, Rennes, Not set
CHU Strasbourg - Nouvel Hopital Civil, Strasbourg, Not set
CHU de Toulouse - Hôpital Larrey, Toulouse cedex 9, Not set
Helios Klinikum Emil von Behring GmbH, Berlin, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
St. Vincentius Kliniken Karlsruhe, Karlsruhe, Not set
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Medizinische Klinik, Pneumologie, Mainz, Not set
Klinikum der Philipps-Universität Marburg, Marburg, Not set
Hong Kong United Oncology Centre, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Tuen Mun Hospital, Hong Kong, Not set
Prince of Wales Hospital, Shatin, Not set
Centro Di Riferimento Oncologico, Aviano, Friuli-Venezia Giulia
A.O. Villa Scassi, Genova, Liguria
Azienda Ospedaliero-Universitaria Careggi, Firenze, Toscana
Kurume University Hospital, Fukuoka, Not set
Hiroshima University Hospital, Hiroshima, Not set
Takarazuka City Hospital, Hyogo, Not set
University Hospital Kyoto Prefectural University of Medicine, Kyoto, Not set
Sendai Kousei Hospital, Miyagi, Not set
Osaka International Cancer Institute, Osaka, Not set
Kansai Medical University Hospital, Osaka, Not set
Kindai University Hospital, Osaka, Not set
NHO Kinki Chuo Chest Medical Center, Osaka, Not set
Saitama Cancer Center, Saitama, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Kosin University Gospel Hospital, Busan, Not set
Chungnam National University Hospital, Daejeon, Not set
St. Vincent's Hospital, Gyeonggi-do, Not set
Samsung Changwon Hospital, Gyeongsangnam-do, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Seoul St Mary's Hospital, Seoul, Not set
Health Pharma Professional Research, Cdmx, Mexico CITY (federal District)
Cuidados oncologicos, Querétaro, Queretaro
ARKE Estudios Clínicos S.A. de C.V., Ciudad de México, Not set
Auckland City Hospital, Cancer and Blood Research, Auckland, Not set
Waikato Hospital - Cancer and Blood Research Trials Unit, Hamilton, Not set
Palmerston North Hospital, Palmerston North, Not set
Tauranga Hospital, Clinical Trials Unit, Tauranga, Not set
Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna, Lodz, Not set
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn, Not set
ICO L'Hospitalet, L Hospitalet De Llobregat, Barcelona
Hospital Son Llatzer, Palma de Mallorca, Islas Baleares
Complejo Hospitalario Universitario Insular?Materno Infantil, Las Palmas de Gran Canaria, LAS Palmas
Hospital del Mar, Barcelona, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruna, Not set
Hospital Lucus Augusti, Lugo, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Univ. Nuestra Señora de Valme, Sevilla, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Kantonsspital Aarau, Aarau, Not set
Kantonsspital Graubünden Medizin Onkologie, Chur, Not set
UniversitätsSpital Zürich, Zürich, Not set
Changhua Christian Hospital, Chang Hua, Not set
China Medical University Hospital, Taichung, Not set
Taipei Veterans General Hospital, Taipei City, Not set
Chulalongkorn Hospital, Bangkok, Not set
Faculty of Med. Siriraj Hosp., Bangkok, Not set
Maharaj Nakorn Chiang Mai Hospital, ChiangMai, Not set
Songklanagarind Hospital, Songkhla, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Dicle University Faculty of Medicine, Diyarbakir, Not set
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set
Medeniyet University Goztepe Training and Research Hospital., Kadiköy, Not set
Castle Hill Hospital, Hull, Not set
Barts & London School of Med, London, Not set
Guy'S Hospital, London, Not set
Christie Hospital Nhs Trust, Manchester, Not set
Nottingham City Hospital, Nottingham, Not set
Conditions: Non-small Cell Lung Cancer (NSCLC)
Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer
Active Not Recruiting
This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together to treat patients with urothelial cancer. The study will compare these drugs to other drugs that are usually used to treat this cancer (standard of care). The patients in this study will have cancer that has spread from their urinary system to other parts of their body.
This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together to treat patients with urothelial cancer. The study will compare these drugs to other drugs that are usually used to treat this cancer (standard of care). The patients in this study will have cancer that has spread from their urinary system to other parts of their body. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2025
Locations: Ironwood Cancer & Research Centers - Chandler, Chandler, Arizona +259 locations
Ironwood Cancer & Research Centers - Chandler, Chandler, Arizona
Arizona Oncology Associates PD - HOPE, Tucson, Arizona
Providence St Joseph Medical Center, Burbank, California
City of Hope National Medical Center, Duarte, California
University of California Los Angeles Medical Center, Los Angeles, California
University of California Irvine - Newport, Orange, California
Rocky Mountain Cancer Centers - Aurora, Aurora, Colorado
University of Colorado Hospital / University of Colorado, Aurora, Colorado
Cancer Centers of Colorado - Denver, Denver, Colorado
Yale Cancer Center, New Haven, Connecticut
Eastern CT Hematology and Oncology Associates, Norwich, Connecticut
Lombardi Cancer Center / Georgetown University Medical Center, Washington, District of Columbia
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Winship Cancer Institute / Emory University School of Medicine, Atlanta, Georgia
Georgia Cancer Specialists / Northside Hospital Cancer Institute, Marietta, Georgia
Louisiana State University/ East Jefferson General Hospital, Metairie, Louisiana
Maine Health Cancer Care, Biddeford, Maine
Johns Hopkins Medical Center, Baltimore, Maryland
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
New Mexico Cancer Center, Albuquerque, New Mexico
New York University (NYU) Cancer Institute, New York, New York
Mount Sinai Medical Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Vidant Medical Center, Greenville, North Carolina
The Cleveland Clinic, Cleveland, Ohio
Toledo Clinic Cancer Center, Toledo, Ohio
Hillman Cancer Center / University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Saint Francis Hospital / Bon Secours - South Carolina, Greenville, South Carolina
West Cancer Center & Research Institute, Germantown, Tennessee
University of Texas Southwestern Medical Center, Dallas, Texas
UT Health East Texas Hope Cancer Center, Tyler, Texas
Huntsman Cancer Institute, Salt Lake City, Utah
University of Virginia, Charlottesville, Virginia
Seattle Cancer Care Alliance / University of Washington, Seattle, Washington
Site AR54008, Buenos Aire, Not set
Site AR54011, Caba, Not set
Site AR54005, Cordoba, Not set
Site AR54006, La Rioja, Not set
Site AR54004, Mendoza, Not set
Site AR54001, Rosario, Not set
Site AR54002, San Miguel, Not set
Site AR54012, Tucuman, Not set
Site AR54003, Viedma, Not set
Site AU61003, Box Hill, Not set
Site AUS61001, Douglas, Not set
Site AUS61004, Heidelberg, Not set
Site AUS61002, Macquarie Park, Not set
Site AUS61006, South Australia, Not set
Site AU61005, South Brisbane, Not set
Site BE32003, Brussels, Not set
Site BE32002, Ghent, Not set
Site BE32001, Liege, Not set
Site BE32007, Lueven, Not set
Site BE32006, Roeselare, Not set
Site CA11004, Calgary, Alberta
Site CA11003, Edmonton, Alberta
Site CA11006, Vancouver, British Columbia
Site CA11002, Hamilton, Ontario
Site CA11009, London, Ontario
Site CA11011, Oshawa, Ontario
Site CA11012, Toronto, Ontario
Site CA11005, Toronto, Ontario
Site CA11010, Montreal, Quebec
Site CA11001, Montreal, Quebec
Site CA11008, Quebec, Not set
Site CN86009, Beijing City, Not set
Site CN86001, Beijing, Not set
Site CN86004, Beijing, Not set
Site CN86005, Beijing, Not set
Site CN86015, Bengbu, Not set
Site CN86003, Changchun, Not set
Site CN86006, Changsha, Not set
Site CN86016, Changsha, Not set
Site CN86010, Chengdu, Not set
Site CN86024, Chongqing, Not set
Site CN86007, Chongqing, Not set
Site CN86028, Fuzhou, Not set
Site CN86002, Guangzhou, Not set
Site CN86020, Gunagzhou, Not set
Site CN86018, Hangzhou, Not set
Site CN86013, Hangzhou, Not set
Site CN86022, Hangzhou, Not set
Site CN86025, Hefei, Not set
Site CN86027, Jinan, Not set
Site CN86017, Nanjing, Not set
Site CN86012, Nanjing, Not set
Site CN86021, Ningbo, Not set
Site CN86014, Shanghai, Not set
Site CN86011, Shenyang City, Not set
Site CN86023, Tianjin, Not set
Site CN86019, Tianjin, Not set
Site CN86029, Wenzhou, Not set
Site CN86008, Wuhan City, Not set
Site CN86030, Xicheng District, Not set
Site CN86026, Xuzhou, Not set
Site CZ42006, Brno, Not set
Site CZ42001, Hradec Kralove, Not set
Site CZ42004, Olomouc, Not set
Site CZ42005, Praha 4-Krc, Not set
Site DK45001, Aalborg, Not set
Site DK45003, Aarhus N, Not set
Site FR33014, Bordeaux, Not set
Site FR33016, Lyon, Not set
Site FR33003, Nice Cedex 2, Not set
Site FR33020, Pierre-Bénite, Not set
Site FR33013, Strasbourg, Not set
Site FR33017, TOURS Cedex 09, Not set
Site FR33011, Villejuif-Cedex-France, Not set
Site DE49003, Berlin, Not set
Site DE49013, Bielefeld, Not set
Site DE49016, Düsseldorf, Not set
Site DE49014, Erlangen, Not set
Site DE49011, Essen, Not set
Site DE49007, Frankfurt am Main, Not set
Site DE49015, Gottingen, Not set
Site DE49005, Heidelberg, Not set
Site DE49009, Herne, Not set
Site DE49006, Jena, Not set
Site DE49001, Lubeck, Not set
Site DE49008, Magdeburg, Not set
Site DE49012, Mannheim, Not set
Site DE49002, Munchen, Not set
Site DE49004, Tübingen, Not set
Site DE49010, Ulm, Not set
Site HU36003, Budapest, Not set
Site HU36002, Budapest, Not set
Site HU36006, Debrecen, Not set
Site HU36001, Nyiregyhaza, Not set
Site HU36005, Szolnok, Not set
Site IL97203, Beer Sheva, Not set
Site IL97201, Haifa, Not set
Site IL97209, Holon, Not set
Site IL97206, Jerusalem, Not set
Site IL97202, Kfar Saba, Not set
Site IL97208, Petach Tikva, Not set
Site IL97211, Rehovot, Not set
Site IL97210, Tel Aviv, Not set
Site IL97204, Tel Hashomer, Not set
Site IL97205, Zerifin, Not set
Site IT39005, Areezo, Not set
Site IT39008, Candiolo, Not set
Site IT39009, Cremona, Not set
Site IT39006, Genova, Not set
Site IT39003, Meldola, Not set
Site IT39014, Milano, Not set
Site IT39007, Milano, Not set
Site IT39004, Pisa, Not set
Site IT39002, Terni, Not set
Site IT39011, Torrette, Not set
Site IT39001, Verona, Not set
Site JP81002, Bunkyo City, Not set
Site JP81009, Chiba, Not set
Site JP81018, Chiba, Not set
Site JP81013, Fukuoka, Not set
Site JP81020, Fukuoka, Not set
Site JP81011, Hirosaki, Not set
Site JP81006, Kawasaki-shi, Not set
Site JP81001, Koto-ku, Not set
Site JP81017, Kyoto, Not set
Site JP81015, Niigata, Not set
Site JP81005, Okayama, Not set
Site JP81016, Osakasayama-Shi, Not set
Site JP81008, Osaka, Not set
Site JP81007, Sapporo, Not set
Site JP81012, Sendai-city, Not set
Site JP81014, Tokushima, Not set
Site JP81019, Tokyo, Not set
Site JP81003, Toyama, Not set
Site JP81004, Tsukuba, Not set
Site JP81010, Ube, Not set
Site KR82001, Daejeon, Not set
Site KR82002, Goyang-si, Not set
Site KR82008, Hwasun, Not set
Site KR82004, Seongnam-si, Not set
Site KR82003, Seoul, Not set
Site KR82005, Seoul, Not set
Site KR82007, Seoul, Not set
Site KR82006, Seoul, Not set
Site NL31005, Amsterdam, Noord-Holland, Not set
Site NL31002, Amsterdam, Not set
Site NL31001, Amsterdam, Not set
Site NL31007, Leeuwarden, Not set
Site NL31004, Nieuwegein, Not set
Site NL31003, Rotterdam, Not set
Site NL31006, Utrecht, Not set
Site PL48002, Warszawa, Not set
Site RU70016, Arkhangelsk, Not set
Site RU70013, Barnaul, Not set
Site RU70020, Ivanovo, Not set
Site RU70014, Krasnoyarsk, Not set
Site RU70006, Leningradskaya Oblast', Not set
Site RU70004, Moscow, Not set
Site RU70011, Moscow, Not set
Site RU70003, Moscow, Not set
Site RU70017, Nizhniy Novgorod, Not set
Site RU70002, Omsk, Not set
Site RU70019, Pyatigorsk, Not set
Site RU70010, Saint Petersburg, Not set
Site RU70007, Saint Petersburg, Not set
Site RU70012, Saint-Petersburg, Not set
Site RU70009, Saransk, Not set
Site RU70008, St. Petersburg, Not set
Site RU70015, Tyumen, Not set
Site RU70005, Ufa, Not set
Site SG65001, Singapore, Not set
Site SG65002, Singapore, Not set
Site SG65003, Singapore, Not set
Site ES34017, Barcelona, Not set
Site ES34010, Barcelona, Not set
Site ES34006, Barcelona, Not set
Site ES34001, Barcelona, Not set
Site ES34008, Barcelona, Not set
Site ES34013, Cordoba, Not set
Site ES34021, Lugo, Not set
Site ES34018, Madrid, Not set
Site ES34002, Madrid, Not set
Site ES34003, Madrid, Not set
Site ES34015, Madrid, Not set
Site ES34004, Manresa, Not set
Site ES34020, Pamplona, Not set
Site ES34016, Sabadell, Not set
Site ES34012, Santander, Not set
Site ES34007, Sevilla, Not set
Site ES34019, Valencia, Not set
Site ES34009, Valencia, Not set
Site CH41004, Basel, Not set
Site CH41002, Bern, Not set
Site CH41001, Chur, Not set
Site CH41003, Winterthur, Not set
Site TW88603, Kaohsiung, Not set
Site TW88602, Kweishan, Not set
Site TW88607, Taichung, Not set
Site TW88606, Taichung, Not set
Site TW88604, Tainan, Not set
Site TW88605, Taipei, Not set
Site TW88601, Taipei, Not set
Site TH66004, Bangkok, Not set
Site TH66003, Bangkok, Not set
Site TH66005, Chiang Mai, Not set
Site TH66002, HatYai, Not set
Site TH66006, Krung Thep Maha Nakhon, Not set
Site TH66007, Muang, Not set
Site TH66001, Ratchathewi, Not set
Site TR90007, Ankara, Not set
Site TR90009, Ankara, Not set
Site TR90005, Antalya, Not set
Site TR90004, Edirne, Not set
Site TR90008, Istanbul, Not set
Site TR90003, Istanbul, Not set
Site TR90002, Istanbul, Not set
Site TR90001, Konya, Not set
Site TR90006, Malatya, Not set
Site UK44005, Glasgow, Not set
Site UK44001, London, Not set
Site UK44009, London, Not set
Site UK44006, Oxford, Not set
Site UK44010, Plymouth, Not set
Site UK44002, Preston, Not set
Site UK44003, Sheffield, Not set
Site UK44008, Southampton, Not set
Conditions: Urothelial Cancer
First-line Treatment of Participants With Stage IV Squamous Non-Small Cell Lung Cancer With Necitumumab and Gemcitabine-Cisplatin
Completed
The research study is testing the investigational drug necitumumab (IMC-11F8) in the treatment of advanced non-small cell lung cancer. The aim of this study is to determine if necitumumab, given together with a standard chemotherapy combination consisting of cisplatin and gemcitabine will be more effective in improving participant disease than the standard chemotherapy combination alone.
The research study is testing the investigational drug necitumumab (IMC-11F8) in the treatment of advanced non-small cell lung cancer. The aim of this study is to determine if necitumumab, given together with a standard chemotherapy combination consisting of cisplatin and gemcitabine will be more effective in improving participant disease than the standard chemotherapy combination alone. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2025
Locations: ImClone Investigational Site, Chandler, Arizona +181 locations
ImClone Investigational Site, Chandler, Arizona
ImClone Investigational Site, Fayetteville, Arkansas
ImClone Investigational Site, Sacramento, California
ImClone Investigational Site, Galesburg, Illinois
ImClone Investigational Site, Goshen, Indiana
ImClone Investigational Site, Wichita, Kansas
ImClone Investigational Site, Hazard, Kentucky
ImClone Investigational Site, Baltimore, Maryland
ImClone Investigational Site, Jefferson City, Missouri
ImClone Investigational Site, Lincoln, Nebraska
ImClone Investigational Site, New York, New York
ImClone Investigational Site, Akron, Ohio
ImClone Investigational Site, Camp Hill, Pennsylvania
ImClone Investigational Site, Memphis, Tennessee
ImClone Investigational Site, Fairfax, Virginia
ImClone Investigational Site, Garran, New South Wales
ImClone Investigational Site, Westmead, New South Wales
ImClone Investigational Site, Wollongong, New South Wales
ImClone Investigational Site, East Bentleigh, Victoria
ImClone Investigational Site, Geelong, Victoria
ImClone Investigational Site, Linz, Not set
ImClone Investigational Site, Wien, Not set
ImClone Investigational Site, Wien, Not set
ImClone Investigational Site, Duffel, Not set
ImClone Investigational Site, Liege, Not set
ImClone Investigational Site, Namur, Not set
ImClone Investigational Site, Barretos, Not set
ImClone Investigational Site, Brasilia, Distrito Federal, Not set
ImClone Investigational Site, Goiania, Not set
ImClone Investigational Site, Ijui, Not set
ImClone Investigational Site, Itajai, Not set
ImClone Investigational Site, Lajeado, Not set
ImClone Investigational Site, Porto Alegre/RS, Not set
ImClone Investigational Site, Salvador, Not set
ImClone Investigational Site, Santo Andre, Not set
ImClone Investigational Site, Sao Paulo, Not set
ImClone Investigational Site, São Paulo - SP, Not set
ImClone Investigational Site, Saint John, New Brunswick
ImClone Investigational Site, Brampton, Ontario
ImClone Investigational Site, Saskatoon, Saskatchewan
ImClone Investigational Site, Dubrovnik, Not set
ImClone Investigational Site, Pula, Not set
ImClone Investigational site, Zagreb, Not set
ImClone Investigational Site, Brest Cedex, Not set
ImClone Investigational Site, Caen, Not set
ImClone Investigational Site, Draguignan, Not set
ImClone Investigational Site, Grenoble, Not set
ImClone Investigational Site, Le Mans Cedex, Not set
ImClone Investigational Site, Le Mans, Not set
ImClone Investigational Site, Lille, Not set
ImClone Investigational Site, Lyon, Not set
ImClone Investigational Site, Marseille, Not set
ImClone Investigational Site, Paris, Not set
ImClone Investigational Site, Paris, Not set
ImClone Investigational Site, Paris, Not set
ImClone Investigational Site, Paris, Not set
ImClone Investigational Site, Rennes, Not set
ImClone Investigational Site, Saint-Jean, Not set
ImClone Investigational Site, Toulon Armées, Not set
ImClone Investigational Site, Berlin, Not set
ImClone Investigational Site, Essen, Not set
ImClone Investigational Site, Essen, Not set
ImClone Investigational Site, Frankfurt, Not set
ImClone Investigational Site, Gauting, Not set
ImClone Investigational Site, Großhansdorf, Not set
ImClone Investigational Site, Halle, Not set
ImClone Investigational Site, Hamburg, Not set
ImClone Investigational Site, Hamburg, Not set
ImClone Investigational Site, Heidelberg, Not set
ImClone Investigational Site, Hemer, Not set
ImClone Investigational Site, Hofheim, Not set
ImClone Investigational Site, Karlsruhe, Not set
ImClone Investigational Site, Lostau, Not set
ImClone Investigational Site, Löwenstein, Not set
ImClone Investigational Site, München, Not set
ImClone Investigational Site, Münster, Not set
ImClone Investigational Site, Regensburg, Not set
ImClone Investigational Site, Regensburg, Not set
ImClone Investigational Site, Ulm, Not set
ImClone Investigational Site, Athens, Not set
ImClone Investigational Site, Heraklion, Crete, Not set
ImClone Investigational Site, Patras, Not set
ImClone Investigational Site, Thessaloniki, Not set
ImClone Investigational Site, Budapest, Not set
ImClone Investigational Site, Budapest, Not set
ImClone Investigational Site, Deszk, Not set
ImClone Investigational Site, Farkasgyepü, Not set
ImClone Investigational Site, Mosonmagyaróvár, Not set
ImClone Investigational Site, Szombathely, Not set
ImClone Investigational Site, Székesfehérvár, Not set
ImClone Investigational Site, Törökbálint, Not set
ImClone Investigational Site, Lido di Camaiore, Lucca
ImClone Investigational Site, Aviano, Pordenone
ImClone Investigational Site, Frosinone, Not set
ImClone Investigational Site, Genova, Not set
ImClone Investigational Site, Milano, Not set
ImClone Investigational Site, Milano, Not set
ImClone Investigational Site, Monza, Not set
ImClone Investigational Site, Parma, Not set
ImClone Investigational Site, Perugia, Not set
ImClone Investigational Site, Incheon, Not set
ImClone Investigational Site, Jeonju-si, Not set
ImClone Investigational Site, Seongnam, Not set
ImClone Investigational Site, Seoul, Not set
ImClone Investigational Site, Seoul, Not set
ImClone Investigational Site, Seoul, Not set
ImClone Investigational Site, Suwon, Not set
ImClone Investigational Site, Cebu City, Not set
ImClone Investigational Site, Cebu, Not set
ImClone Investigational Site, Davao City, Not set
ImClone Investigational Site, Makati City, Not set
ImClone Investigational Site, Manila, Not set
ImClone Investigational Site, Quezon City, Not set
ImClone Investigational Site, Quezon City, Not set
ImClone Investigational Site, Olsztyn, Not set
ImClone Investigational Site, Otwock, Not set
ImClone Investigational Site, Poznan, Not set
ImClone Investigational Site, Radom, Not set
ImClone Investigational Site, Rzeszow, Not set
ImClone Investigational Site, Szczecin, Not set
ImClone Investigational Site, Torun, Not set
ImClone Investigational Site, Wroclaw, Not set
ImClone Investigational Site, Coimbra, Not set
ImClone Investigational Site, Lisboa, Not set
ImClone Investigational Site, Lisboa, Not set
ImClone Investigational Site, Porto, Not set
ImClone Investigational Site, Brasov, Not set
ImClone Investigational Site, Bucharest, Not set
ImClone Investigational Site, Bucharest, Not set
ImClone Investigational Site, Cluj-Napoca, Not set
ImClone Investigational Site, Craiova, Dolj, Not set
ImClone Investigational Site, Iasi, Not set
ImClone Investigational Site, Piatra Neamt, Not set
ImClone Investigational Site, Sibiu, Not set
ImClone Investigational Site, Ivanovo, Not set
ImClone Investigational Site, Kirov, Not set
ImClone Investigational Site, Krasnodar, Not set
ImClone Investigational Site, Moscow, Not set
ImClone Investigational Site, Omsk, Not set
ImClone Investigational Site, Smolensk, Not set
ImClone Investigational Site, St. Petersburg, Not set
ImClone Investigational Site, St. Petersburg, Not set
ImClone Investigational Site, St. Petersburg, Not set
ImClone Investigational Site, St. Petersburg, Not set
ImClone Investigational Site, Ufa, Not set
ImClone Investigational Site, Yaroslavl, Not set
ImClone Investigational Site, Belgrade, Not set
ImClone Investigational Site, Kragujevac, Not set
ImClone Investigational Site, Nis, Not set
ImClone Investigational Site, Sremska Kamenica, Not set
ImClone Investigational Site, Singapore, Not set
ImClone Investigational Site, Bratislava, Not set
ImClone Investigational Site, Nitra, Not set
ImClone Investigational Site, Poprad, Not set
ImClone Investigational Site, Bloemfontein, Free State
ImClone Investigational Site, Pretoria, Gauteng
ImClone Investigational Site, Durban, Kwazulu-Natal
ImClone Investigational Site, Sevilla, Andalucía
ImClone Investigational Site, Avila, Castilla Y Leon
ImClone Investigational Site, Barcelona, Cataluña
ImClone Investigational Site, Barcelona, Cataluña
ImClone Investigational Site, Terrassa, Cataluña
ImClone Investigational Site, Madrid, Communidad De Madrid
ImClone Investigational Site, Madrid, Communidad De Madrid
ImClone Investigational Site, Majadahonda, Communidad De Madrid
ImClone Investigational Site, Barcelona, Not set
ImClone Investigational Site, L'Hospitalet de Llobregat, Not set
ImClone Investigational Site, Madrid, Not set
ImClone Investigational Site, Taichung, Not set
ImClone Investigational Site, Taichung, Not set
ImClone Investigational Site, Chiang Mai, Not set
ImClone Investigational Site, Songkhla, Not set
ImClone Investigational Site, Aberdeen, Not set
ImClone Investigational Site, Bournemouth, Not set
ImClone Investigational Site, Dundee, Not set
ImClone Investigational Site, Edinburgh, Not set
ImClone Investigational Site, Guildford, Not set
ImClone Investigational Site, Liverpool, Not set
ImClone Investigational Site, London, Not set
ImClone Investigational Site, Manchester, Not set
ImClone Investigational Site, Manchester, Not set
ImClone Investigational Site, Preston, Not set
Conditions: Non Small Cell Lung Cancer
A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer
Active Not Recruiting
The purpose of this study is to compare nivolumab plus neoadjuvant gemcitabine/cisplatin (GC) chemotherapy, followed by post-surgery continuation of immuno-oncology (IO) therapy, with neoadjuvant GC chemotherapy alone in adult participants with previously untreated muscle-invasive bladder cancer (MIBC).
The purpose of this study is to compare nivolumab plus neoadjuvant gemcitabine/cisplatin (GC) chemotherapy, followed by post-surgery continuation of immuno-oncology (IO) therapy, with neoadjuvant GC chemotherapy alone in adult participants with previously untreated muscle-invasive bladder cancer (MIBC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Local Institution - 0022, Tucson, Arizona +171 locations
Local Institution - 0022, Tucson, Arizona
UC Davis Comprehensive Cancer Center, Sacramento, California
Local Institution - 0021, Littleton, Colorado
Local Institution - 0036, Pensacola, Florida
Local Institution - 0004, Tampa, Florida
Local Institution - 0144, Atlanta, Georgia
Local Institution - 0005, Chicago, Illinois
Local Institution - 0006, Peoria, Illinois
Local Institution - 0181, Columbia, Maryland
Local Institution - 0009, Boston, Massachusetts
Local Institution - 0166, Boston, Massachusetts
Local Institution - 0209, Boston, Massachusetts
Local Institution - 0025, Minneapolis, Minnesota
Local Institution - 0129, Minneapolis, Minnesota
Local Institution - 0183, Omaha, Nebraska
Local Institution - 0001, Omaha, Nebraska
Local Institution - 0024, Las Vegas, Nevada
Local Institution - 0029, Albany, New York
Local Institution - 0069, Lake Success, New York
Local Institution - 0047, New York, New York
Local Institution - 0191, Cleveland, Ohio
Local Institution - 0028, Tigard, Oregon
Local Institution - 0189, Charleston, South Carolina
Local Institution - 0007, Nashville, Tennessee
Local Institution - 0030, Austin, Texas
Local Institution - 0023, Norfolk, Virginia
Local Institution - 0051, Capital Federal, Buenos Aires
Local Institution - 0049, Ciudad Autónoma de Buenos Aires, Buenos Aires
Local Institution - 0151, Ciudad Autonoma Buenos Aires, Distrito Federal
Local Institution - 0131, Garran, Australian Capital Territory
Local Institution - 0130, Kingswood, New South Wales
Local Institution - 0157, Macquarie University, New South Wales
Local Institution - 0043, St Leonards, New South Wales
Local Institution - 0143, North Adelaide, South Australia
Local Institution - 0037, Heidelberg, Victoria
Local Institution - 0038, Murdoch, Western Australia
Local Institution - 0090, Klagenfurt Am Woerthersee, Not set
Local Institution - 0091, Krems, Not set
Local Institution - 0011, Linz, Not set
Local Institution - 0012, Wien, Not set
Local Institution - 0060, Bruxelles, Not set
Local Institution - 0063, Gent, Not set
Local Institution - 0062, Wilrijk, Not set
Local Institution - 0094, Fortaleza, Ceara
Local Institution - 0099, Ipatinga, Minas Gerais
Local Institution - 0092, Ijui, RIO Grande DO SUL
Local Institution - 0212, Porto Alegre, RIO Grande DO SUL
Local Institution - 0097, Porto Alegre, RIO Grande DO SUL
Local Institution - 0098, Barretos, Sao Paulo
Local Institution - 0095, Jau, Sao Paulo
Local Institution - 0093, Sao Jose Do Rio Preto, Sao Paulo
Local Institution - 0164, Rio De Janeiro, Not set
Local Institution - 0214, Sao Paulo, Not set
Local Institution - 0159, Kelowna, British Columbia
Local Institution - 0182, North York, Ontario
Local Institution - 0192, Chicoutimi, Quebec
Local Institution - 0190, Montreal, Quebec
Local Institution - 0053, Santiago, Metropolitana
Local Institution - 0052, Santiago, Metropolitana
Local Institution - 0210, Santiago, Metropolitana
Local Institution - 0054, Santiago, Metropolitana
Local Institution - 0201, Colombia, Bogota
Local Institution - 0104, Bucaramanga, Not set
Local Institution - 0103, Monteria, Not set
Local Institution - 0148, Helsinki, Not set
Local Institution - 0145, Tampere, Not set
Local Institution - 0146, Turku, Not set
Local Institution - 0202, Brest, Finistère
Local Institution - 0204, Créteil, Val-de-Marne
Local Institution - 0205, Amiens, Not set
Local Institution - 0198, Angers, Not set
Local Institution - 0101, Besancon, Not set
Local Institution - 0217, Bordeaux, Not set
Local Institution - 0199, Clermont-ferrand, Not set
Local Institution - 0206, La Tronche, Not set
Local Institution - 0075, Marseille, Not set
Local Institution - 0200, Montpellier Cedex 5, Not set
Local Institution - 0074, Nice, Not set
Local Institution - 0163, Paris, Not set
Local Institution - 0020, Pierre Benite Cedax, Not set
Local Institution - 0188, Saint Herblain Cedex, Not set
Local Institution - 0002, Strasbourg Cedex, Not set
Local Institution - 0003, TOULOUSE Cedex 9, Not set
Local Institution - 0100, Mainz, Rheinland-Pfalz
Local Institution - 0078, Aachen, Not set
Local Institution - 0015, Erfurt, Not set
Local Institution - 0081, Essen, Not set
Local Institution - 0086, Frankfurt Main, Not set
Local Institution - 0080, Goettingen, Not set
Local Institution - 0013, Herne, Not set
Local Institution - 0010, Jena, Not set
Local Institution - 0084, Luebeck, Not set
Local Institution - 0079, Magdeburg, Not set
Local Institution - 0082, Muenchen, Not set
Local Institution - 0016, Nuernberg, Not set
Local Institution - 0085, Trier, Not set
Local Institution - 0195, Athens, Attikí
Local Institution - 0031, Larissa, Thessalía
Local Institution - 0194, Chaidari, Not set
Local Institution - 0196, Tel Aviv, Tel-Aviv
Local Institution - 0068, Beer Sheva, Not set
Local Institution - 0066, Haifa, Not set
Local Institution - 0067, Ramat Gan, Not set
Local Institution - 0064, Bari, Not set
Local Institution - 0193, Meldola (fc), Not set
Local Institution - 0032, Milano, Not set
Local Institution - 0065, Modena, Not set
Local Institution - 0033, Padova, Not set
Local Institution - 0034, Pisa, Not set
Local Institution - 0035, Roma, Not set
Local Institution - 0186, Komaki, Aichi
Local Institution - 0184, Sapporo, Hokkaido
Local Institution - 0177, Sapporo, Hokkaido
Local Institution - 0185, Sapporo, Hokkaido
Local Institution - 0179, Tsukuba-shi, Ibaraki
Local Institution - 0171, Kita-gun, Kagawa
Local Institution - 0169, Yokohama, Kanagawa
Local Institution - 0168, Niigata-shi, Niigata
Local Institution - 0173, Osakasayama, Osaka
Local Institution - 0175, Takatsuki City, Osaka
Local Institution - 0176, Hidaka-shi, Saitama
Local Institution - 0170, Hamamatasu, Shizuoka
Local Institution - 0178, Minato-ku, Tokyo
Local Institution - 0172, Shinjuku-ku, Tokyo
Local Institution - 0174, Fukuoka, Not set
Local Institution - 0180, Kyoto, Not set
Local Institution - 0137, Goyang-si, Gyeonggi-do
Local Institution - 0203, Seongnam-si, Kyǒnggi-do
Local Institution - 0220, Busan, Not set
Local Institution - 0218, Daegu, Not set
Local Institution - 0208, Gyeongsangnam-do, Not set
Local Institution - 0215, Seongnam-si,, Not set
Local Institution - 0140, Seoul, Not set
Local Institution - 0136, Seoul, Not set
Local Institution - 0211, Seoul, Not set
Local Institution - 0138, Seoul, Not set
Local Institution - 0160, La Paz, BAJA Californa SUR
Local Institution - 0102, Zapopan, Jalisco
Local Institution - 0056, Monterrey, Nuevo LEON
Local Institution - 0105, Colima, Not set
Local Institution - 0070, Amsterdam, Not set
Local Institution - 0072, Groningen, Not set
Local Institution - 0073, Sittard-Geleen, Not set
Local Institution - 0087, Auckland, Not set
Local Institution - 0089, Christchurch, Not set
Local Institution - 0158, Gralum, Not set
Local Institution - 0132, Lorenskog, Not set
Local Institution - 0133, Oslo, Not set
Local Institution - 0153, Lisboa, Not set
Local Institution - 0152, Porto, Not set
Local Institution - 0219, Cluj-Napoca, Not set
Local Institution - 0076, Craiova, Not set
Local Institution - 0058, Sector 2, Not set
Local Institution, Saint-Petersburg, Not set
Local Institution, St Petersburg, Not set
Local Institution - 0154, Singapore, Not set
Local Institution - 0113, Lugo, Not set
Local Institution - 0111, Madrid, Not set
Local Institution - 0112, Madrid, Not set
Local Institution - 0114, Madrid, Not set
Local Institution - 0156, Malaga, Not set
Local Institution - 0109, Sevilla, Not set
Local Institution - 0135, Kaohsiung, Not set
Local Institution - 0165, Taichung, Not set
Local Institution - 0141, Taipei City, Not set
Local Institution - 0139, Taipei, Not set
Local Institution - 0128, Chelmsford, Essex
Local Institution - 0127, York, Yorkshire
Local Institution - 0122, Glasgow, Not set
Local Institution - 0117, Lancaster, Not set
Local Institution - 0121, London, Not set
Local Institution - 0124, Oxford, Not set
Conditions: Muscle-Invasive Bladder Cancer, Urinary Bladder Neoplasms
A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
Active Not Recruiting
This is a Phase III, randomised, controlled, 3-arm, multi-centre study of neoadjuvant osimertinib as monotherapy or in combination with chemotherapy, versus SoC chemotherapy alone, for the treatment of patients with resectable EGFRm Non-Small Cell Lung Cancer
This is a Phase III, randomised, controlled, 3-arm, multi-centre study of neoadjuvant osimertinib as monotherapy or in combination with chemotherapy, versus SoC chemotherapy alone, for the treatment of patients with resectable EGFRm Non-Small Cell Lung Cancer Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/22/2025
Locations: Research Site, Duarte, California +158 locations
Research Site, Duarte, California
Research Site, Irvine, California
Research Site, San Francisco, California
Research Site, Santa Monica, California
Research Site, Santa Rosa, California
Research Site, Boston, Massachusetts
Research Site, Lebanon, New Hampshire
Research Site, Commack, New York
Research Site, New York, New York
Research Site, Houston, Texas
Research Site, Fairfax, Virginia
Research Site, Seattle, Washington
Research Site, Graz, Not set
Research Site, Wien, Not set
Research Site, Barretos, Not set
Research Site, Fortaleza, Not set
Research Site, Jau, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Recife, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Santa Maria, Not set
Research Site, Sao Paulo, Not set
Research Site, São José do Rio Preto, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Panagyurishte, Not set
Research Site, Pleven, Not set
Research Site, Sofia, Not set
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Las Condes, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changsha, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Kunming, Not set
Research Site, Nanchang, Not set
Research Site, Nantong, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Suzhou, Not set
Research Site, Urumqi, Not set
Research Site, Wanzhou, Not set
Research Site, Wenzhou, Not set
Research Site, Xiamen, Not set
Research Site, Yangzhou, Not set
Research Site, Avignon Cedex, Not set
Research Site, Bordeaux, Not set
Research Site, Berlin, Not set
Research Site, Bielefeld, Not set
Research Site, Esslingen a.N., Not set
Research Site, Freiburg, Not set
Research Site, Gauting, Not set
Research Site, Georgsmarienhuette, Not set
Research Site, Halle, Not set
Research Site, Köln, Not set
Research Site, Oldenburg, Not set
Research Site, Würzburg, Not set
Research Site, Mumbai, Not set
Research Site, Namakkal, Not set
Research Site, New Delhi, Not set
Research Site, Varanasi, Not set
Research Site, Haifa, Not set
Research Site, Jerusalem, Not set
Research Site, Kfar Saba, Not set
Research Site, Petah Tikva, Not set
Research Site, Ramat Gan, Not set
Research Site, Tel Aviv, Not set
Research Site, Bari, Not set
Research Site, Firenze, Not set
Research Site, Monza, Not set
Research Site, Orbassano, Not set
Research Site, Padova, Not set
Research Site, Rozzano, Not set
Research Site, Varese, Not set
Research Site, Akashi-shi, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Chiba-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Kashiwa, Not set
Research Site, Koto-ku, Not set
Research Site, Kyoto-shi, Not set
Research Site, Niigata-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Sakai-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Shinjuku-ku, Not set
Research Site, Sunto-gun, Not set
Research Site, Yokohama-shi, Not set
Research Site, Daegu, Not set
Research Site, Hwasun-gun, Not set
Research Site, Incheon, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Yangsan-si, Not set
Research Site, Aguascalientes, Not set
Research Site, D.F, Not set
Research Site, Mexico City, Not set
Research Site, La Libertad, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Olsztyn, Not set
Research Site, Kazan, Not set
Research Site, Krasnoyarsk, Not set
Research Site, Moscow, Not set
Research Site, Nizhniy Novgorod, Not set
Research Site, Obninsk, Not set
Research Site, Perm, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint-Petersburg, Not set
Research Site, Barcelona, Not set
Research Site, Madrid, Not set
Research Site, Majadahonda, Not set
Research Site, Málaga, Not set
Research Site, Winterthur, Not set
Research Site, Zürich, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Tainan City, Not set
Research Site, Taipei City, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Chiang Mai, Not set
Research Site, Khon Kaen, Not set
Research Site, Pathumthani, Not set
Research Site, Phisanulok, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Istanbul, Not set
Research Site, Istanbul, Not set
Research Site, Malatya, Not set
Research Site, Birmingham, Not set
Research Site, Liverpool, Not set
Research Site, Hanoi, Not set
Research Site, Ho Chi Minh, Not set
Research Site, Ho Chi Minh, Not set
Conditions: Non-Small Cell Lung Cancer
Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer
Active Not Recruiting
A Phase III, Randomized, Open-Label, Controlled, Multi-Center, Global Study of First-Line MEDI4736 (Durvalumab) Monotherapy and MEDI4736 (Durvalumab) in Combination with Tremelimumab Versus Standard of Care Chemotherapy in Patients with Stage IV Urothelial Cancer
A Phase III, Randomized, Open-Label, Controlled, Multi-Center, Global Study of First-Line MEDI4736 (Durvalumab) Monotherapy and MEDI4736 (Durvalumab) in Combination with Tremelimumab Versus Standard of Care Chemotherapy in Patients with Stage IV Urothelial Cancer Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
05/21/2025
Locations: Research Site, Los Angeles, California +221 locations
Research Site, Los Angeles, California
Research Site, Stanford, California
Research Site, Aurora, Colorado
Research Site, New Haven, Connecticut
Research Site, Tampa, Florida
Research Site, Atlanta, Georgia
Research Site, Louisville, Kentucky
Research Site, Boston, Massachusetts
Research Site, Ann Arbor, Michigan
Research Site, Detroit, Michigan
Research Site, Omaha, Nebraska
Research Site, New York, New York
Research Site, New York, New York
Research Site, Memphis, Tennessee
Research Site, Nashville, Tennessee
Research Site, Seattle, Washington
Research Site, Box Hill, Not set
Research Site, Elizabeth Vale, Not set
Research Site, Macquarie University, Not set
Research Site, St Leonards, Not set
Research Site, Waratah, Not set
Research Site, Linz, Not set
Research Site, Wien, Not set
Research Site, Wien, Not set
Research Site, Brussels, Not set
Research Site, Bruxelles, Not set
Research Site, Leuven, Not set
Research Site, Liège, Not set
Research Site, Barretos, Not set
Research Site, Belo Horizonte, Not set
Research Site, Ijui, Not set
Research Site, Itajai, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Porto Alegre, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Rio de Janeiro, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, Sao Paulo, Not set
Research Site, São José do Rio Preto, Not set
Research Site, Calgary, Alberta
Research Site, Edmonton, Alberta
Research Site, Kelowna, British Columbia
Research Site, Vancouver, British Columbia
Research Site, Halifax, Nova Scotia
Research Site, Hamilton, Ontario
Research Site, Newmarket, Ontario
Research Site, Oshawa, Ontario
Research Site, Ottawa, Ontario
Research Site, Toronto, Ontario
Research Site, Toronto, Ontario
Research Site, Sherbrooke, Quebec
Research Site, Quebec, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chongqing, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Nanjing, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Tianjin, Not set
Research Site, Xi'an, Not set
Research Site, Xiamen, Not set
Research Site, Herlev, Not set
Research Site, København Ø, Not set
Research Site, Odense C, Not set
Research Site, Århus C, Not set
Research Site, Bordeaux, Not set
Research Site, Bordeaux, Not set
Research Site, Caen Cedex, Not set
Research Site, Lyon Cedex 08, Not set
Research Site, Marseille cedex 09, Not set
Research Site, Paris Cedex 10, Not set
Research Site, Poitiers Cedex, Not set
Research Site, Suresnes Cedex, Not set
Research Site, Toulouse, Not set
Research Site, Villejuif, Not set
Research Site, Düsseldorf, Not set
Research Site, Erlangen, Not set
Research Site, Hannover, Not set
Research Site, Heidelberg, Not set
Research Site, Jena, Not set
Research Site, München, Not set
Research Site, Münster, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Heraklion, Not set
Research Site, Holargos, Athens, Not set
Research Site, Maroussi, Athens, Not set
Research Site, Patras, Not set
Research Site, Thessaloniki, Not set
Research Site, Haifa, Not set
Research Site, Jerusalem, Not set
Research Site, Petach-Tikva, Not set
Research Site, Ramat Gan, Not set
Research Site, Zerifin, Not set
Research Site, Arezzo, Not set
Research Site, Meldola, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Napoli, Not set
Research Site, Orbassano, Not set
Research Site, Pavia, Not set
Research Site, Roma, Not set
Research Site, San Giovanni Rotondo, Not set
Research Site, Akita-shi, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Hakata-shi, Not set
Research Site, Hirosaki-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Izumo-shi, Not set
Research Site, Kagoshima-shi, Not set
Research Site, Kanazawa-shi, Not set
Research Site, Kita-gun, Not set
Research Site, Kobe-shi, Not set
Research Site, Koshigaya-shi, Not set
Research Site, Koto-ku, Not set
Research Site, Kumamoto-shi, Not set
Research Site, Kyoto-shi, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Morioka-shi, Not set
Research Site, Nagasaki-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Nagoya-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama-shi, Not set
Research Site, Saga-shi, Not set
Research Site, Sagamihara-shi, Not set
Research Site, Sakura-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Suita-shi, Not set
Research Site, Takatsuki-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Incheon, Not set
Research Site, Seongnam-si, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Guadalajara, Not set
Research Site, León, Not set
Research Site, Mexico, D.F, Not set
Research Site, Mexico, Not set
Research Site, Monterrey, Not set
Research Site, México, Not set
Research Site, Amsterdam, Not set
Research Site, Amsterdam, Not set
Research Site, Breda, Not set
Research Site, Enschede, Not set
Research Site, Groningen, Not set
Research Site, Leiden, Not set
Research Site, Maastricht, Not set
Research Site, Nijmegen, Not set
Research Site, Gdańsk, Not set
Research Site, Gdańsk, Not set
Research Site, Gdynia, Not set
Research Site, Gliwice, Not set
Research Site, Olsztyn, Not set
Research Site, Otwock, Not set
Research Site, Szczecin, Not set
Research Site, Warszawa, Not set
Research Site, Lisboa, Not set
Research Site, Loures, Not set
Research Site, Porto, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Murmansk, Not set
Research Site, Nizhnyi Novgorod, Not set
Research Site, Obninsk, Not set
Research Site, Omsk, Not set
Research Site, Saint Petersburg, Not set
Research Site, Saint-Petersburg, Not set
Research Site, St. Petersburg, Not set
Research Site, St. Petersburg, Not set
Research Site, St.Petersburg, Not set
Research Site, Ufa, Not set
Research Site, Yaroslavl, Not set
Research Site, Badajoz, Not set
Research Site, Badalona, Not set
Research Site, Barcelona, Not set
Research Site, Barcelona, Not set
Research Site, Elche(Alicante), Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Pozuelo de Alarcon, Not set
Research Site, Santiago de Compostela, Not set
Research Site, Sevilla, Not set
Research Site, Kaohsiung, Not set
Research Site, Taichung, Not set
Research Site, Tainan, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Taoyuan City, Not set
Research Site, Ankara, Not set
Research Site, Edirne, Not set
Research Site, Izmir, Not set
Research Site, Cambridge, Not set
Research Site, Cardiff., Not set
Research Site, Glasgow, Not set
Research Site, Leeds, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Sheffield, Not set
Research Site, Southampton, Not set
Research Site, Wirral, Not set
Conditions: Urothelial Cancer
SIRT Followed by CIS-GEM Chemotherapy Versus CIS-GEM Chemotherapy Alone as 1st Line Treatment of Patients With Unresectable Intrahepatic Cholangiocarcinoma
Terminated
The study planned to evaluate the benefit of applying Selective Internal Radiation Therapy (SIRT) using SIR-Spheres Y-90 resin microspheres prior to receiving systemic chemotherapy treatment (cisplatin-gemcitabine, or CIS-GEM) in patients with unresectable intrahepatic cholangiocarcinoma. Half of the patients were randomized to CIS-GEM chemotherapy plus SIRT, and half of the patients were randomized to CIS-GEM alone.
The study planned to evaluate the benefit of applying Selective Internal Radiation Therapy (SIRT) using SIR-Spheres Y-90 resin microspheres prior to receiving systemic chemotherapy treatment (cisplatin-gemcitabine, or CIS-GEM) in patients with unresectable intrahepatic cholangiocarcinoma. Half of the patients were randomized to CIS-GEM chemotherapy plus SIRT, and half of the patients were randomized to CIS-GEM alone. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Providence Health Care, Spokane, Washington +22 locations
Providence Health Care, Spokane, Washington
Macquarie University Hospital, North Ryde, New South Wales
Peter MacCallum Cancer Centre, Melbourne, Victoria
Cliniques Universitaires Saint-Luc, Brussels, Not set
Hopital Beaujon, Clichy, Not set
CHU Dijon, Dijon, Not set
CHU de Grenoble, Grenoble, Not set
CHU Lyon - Hospital de la Croix-Rousse, Lyon, Not set
Institut Paoli Calmettes, Marseille, Not set
CHU Montpellier, Montpellier, Not set
CHU Nice - Hopital l'Archet 2, Nice, Not set
Hopital Haut-Leveque, Pessac Cedex, Not set
CHU de Poitiers, Poitiers, Not set
Centre Eugene Marquis Hospital de Jour, Rennes, Not set
Hopital Paul Brousse, Villejuif, Not set
U.O. Oncologia Medica 2 Universitaria, Pisa, Not set
AMC Academic Medical Center, Amsterdam, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Clinica Universitaria de Navarra, Pamplona, Not set
Hammersmith Hospital Imperial College Healthcare NHS Trust, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Southampton General Hospital, Southampton, Not set
The Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, Not set
Conditions: Intrahepatic Cholangiocarcinoma
Personalized Medicine for Advanced Biliary Cancer Patients
Recruiting
The object of this trial is to evaluate whether the introduction of a targeted therapy after 4 cycles of the current standard-of-care treatment for advanced biliary cancer is superior to continuing with the standard treatment.
The trial is composed of two phases: (i) An initial screening phase to identify a suitable patient population, during which a molecular profile of the patient's tumour will be obtained, and (ii) a randomised comparative trial in which patients with disease control after 4... Read More
The object of this trial is to evaluate whether the introduction of a targeted therapy after 4 cycles of the current standard-of-care treatment for advanced biliary cancer is superior to continuing with the standard treatment.
The trial is composed of two phases: (i) An initial screening phase to identify a suitable patient population, during which a molecular profile of the patient's tumour will be obtained, and (ii) a randomised comparative trial in which patients with disease control after 4 cycles of standard treatment, and whose tumour harbours a targetable molecular alteration, will be randomised (2:1) to receive either a matched targeted therapy or to continue with the standard treatment. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Cliniques universitaires Saint-Luc, Brussels, Not set +68 locations
Cliniques universitaires Saint-Luc, Brussels, Not set
Cliniques universitaires de Bruxelles - Hôpital Erasme ULB, Bruxelles, Not set
Universitair Ziekenhuis Antwerpen (UZA), Edegem, Not set
Universitair Ziekenhuis Leuven, Leuven, Not set
CHU Amiens Picardie, Amiens, Not set
CHU d'Angers, Angers, Not set
Institut de cancerologie de l'Ouest - Angers, Angers, Not set
Institut du Cancer Avignon Provence, Avignon, Not set
CHU de Besançon, Besançon, Not set
CHU de Bordeaux - Hôpital Haut-Leveque, Bordeaux, Not set
Centre François Baclesse, Caen, Not set
Centre Jean Perrin, Clermont-Ferrand, Not set
CHU Estaing de Clermont Ferrand, Clermont-Ferrand, Not set
APHP - Hopital Henri Mondor, Créteil, Not set
CHU de Dijon, Dijon, Not set
CHU Grenoble Alpes, Grenoble, Not set
Groupe hospitalier mutaliste de Grenoble - Institut Daniel Hollard, Grenoble, Not set
Centre Oscar Lambret, Lille, Not set
CHU Lille, Lille, Not set
CHU Dupuytren, Limoges, Not set
Centre Leon Bérard, Lyon, Not set
Clinique Privée Jean Mermoz, Lyon, Not set
Hospices Civils de Lyon - Croix Rousse, Lyon, Not set
APHM - CHU La Timone, Marseille, Not set
Hôpital Européen, Marseille, Not set
Institut Paoli Calmettes, Marseille, Not set
Institut de Cancer de Montpellier, Montpellier, Not set
CHU Nantes - Hôtel Dieu, Nantes, Not set
Centre Antoine Lacassagne, Nice, Not set
APHP - Hôpital Beaujon, Paris, Not set
APHP - Hôpital Cochin, Paris, Not set
APHP - Hôpital Saint Antoine, Paris, Not set
Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris, Not set
Institute Mutualiste Montsouris, Paris, Not set
CH de Pau, Pau, Not set
CHU Poitiers, Poitiers, Not set
CH Cornouaille, Quimper, Not set
CHU de Reims, Reims, Not set
Institut Jean Godinot, Reims, Not set
Centre Eugène Marquis, Rennes, Not set
CHU Charles Nicolle, Rouen, Not set
Institut Curie - Saint Cloud, Saint Cloud, Not set
Institut de Cancerologie de l'Ouest, Saint-Herblain, Not set
Hôpital Foch, Suresnes, Not set
CHU Toulouse, Toulouse, Not set
CH Valence, Valence, Not set
CHRU de Nancy, Vandœuvre-lès-Nancy, Not set
APHP - Hôpital Paul Brousse, Villejuif, Not set
Gustave Roussy, Villejuif, Not set
Queen Elizabeth Hospital, Birmingham, Not set
Bristol Haematology and Oncology Centre, Bristol, Not set
Addenbrooke's Hospital, Cambridge, Not set
Castle Hill Hospital, Cottingham, Not set
St James's Hospital, Leeds, Not set
Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, Not set
Guy's & St Thomas' Hospital, London, Not set
Hammersmith Hospital, London, Not set
Royal Free Hospital, London, Not set
Royal Marsden Hospital, London, Not set
University College London, London, Not set
Maidstone Hospital, Maidstone, Not set
The Christie Hospital, Manchester, Not set
Mount Vernon Cancer Centre, Northwood, Not set
Nottingham University Hospital, Nottingham, Not set
Churchill Hospital, Oxford, Not set
North West Anglia NHS Foundation Trust, Peterborough, Not set
Weston Park Cancer Centre, Sheffield, Not set
Southampton General Hospital, Southampton, Not set
Singleton Hospital, Swansea, Not set
Conditions: Biliary Tract Neoplasms
TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations
Active Not Recruiting
The purpose of this study is to compare effectiveness of TAK-788 as first-line treatment with that of platinum-based chemotherapy in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors has epidermal growth factor receptor (EGFR) exon 20 insertion mutations.
Participants will be randomly assigned to one of the two treatment groups- TAK-788 group or Platinum-based chemotherapy group.
Participants will receive TAK-788 orally and pemetrexed/cisplatin or... Read More
The purpose of this study is to compare effectiveness of TAK-788 as first-line treatment with that of platinum-based chemotherapy in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors has epidermal growth factor receptor (EGFR) exon 20 insertion mutations.
Participants will be randomly assigned to one of the two treatment groups- TAK-788 group or Platinum-based chemotherapy group.
Participants will receive TAK-788 orally and pemetrexed/cisplatin or pemetrexed/carboplatin via vein until the participants experience worsening disease (PD) as assessed by blinded independent review committee (IRC), intolerable harmful effects or another discontinuation criteria. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/21/2025
Locations: City of Hope National Medical Center, Long Beach, California +133 locations
City of Hope National Medical Center, Long Beach, California
University of California Irvine, Orange, California
Stanford University, Palo Alto, California
AdventHealth, Orlando, Florida
Northwestern University, Chicago, Illinois
University of Maryland Greenebaum Cancer Center, Baltimore, Maryland
Beth Israel Deaconess Medical Center - 330 Brookline Ave, Boston, Massachusetts
Dana Farber Cancer Institute, Boston, Massachusetts
Massachusetts General Hospital, Boston, Massachusetts
Sarah Cannon Cancer Center, Nashville, Tennessee
University of Virginia Health System, Charlottesville, Virginia
GenesisCare North Shore, St Leonards, New South Wales
Princess Alexandra Hospital, Woolloongabba, Queensland
Flinders Medical Centre, Bedford Park, South Australia
Klinik Floridsdorf, Wien, Not set
Cliniques Universitaires Saint-Luc, Bruxelles, Brussels
Grand Hopital de Charleroi asbl, Charleroi, Hainaut
AZ Sint-Lucas, Aalst, Oost-Vlaanderen
British Columbia Cancer Agency, Vancouver, British Columbia
William Osler Health System, Brampton, Ontario
Princess Margaret Hospital, Toronto, Ontario
Hopital Du Sacre Coeur de Montreal, Montreal, Quebec
Beijing Cancer Hospital - PPDS, Beijing, Beijing
Henan Cancer Hospital, Zhengzhou, Henan
Jilin Cancer Hospital, Changchun, Jilin
Beijing Cancer Hospital - PPDS, Beijing, Not set
Beijing Chest Hospital, Capital Medical Univerity, Beijing, Not set
Icahn School of Medicine at Mount Sinai, Beijing, Not set
Sichuan Cancer Hospital & Institute, Chengdu, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Not set
Harbin Medical University Tumor Hospital, Harbin, Not set
Shanghai East Hospital, Shanghai, Not set
Hubei Cancer Hospital, Wuhan, Not set
Centre Francois Baclesse, Caen, Calvados
CHU de Nantes - Hoptal Nord Laennec, Nantes, Loire-Atlantique
Hopital Calmette, Lille, Nord
Centre Leon Berard, Lyon, Rhone
Institut Gustave Roussy, Villejuif, Val-de-Marne
CHU de Grenoble, Grenoble, Not set
Hopital Nord AP-HM, Marseille, Not set
CRLC Val d'Aurelle - Paul Lamarque, Montpellier, Not set
Hopital Tenon, Paris, Not set
Nouvel Hopital Civil, Strasbourg, Not set
Hopital Larrey, Toulouse, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Baden-Wurttemberg
LMU Klinikum der Universitat Munchen, Munchen, Bayern
University Clinic Regensburg, Regensburg, Bayern
Universitatsklinikum Frankfurt, Frankfurt am Main, Hessen
Pius Hospital Oldenburg, Oldenburg, Niedersachsen
Helios Klinikum Emil Von Behring, Berlin, Not set
Sotiria Chest Hospital of Athens, Athens, Attiki
Bioclinic Thessaloniki (Galinos clinic), Thessaloniki, Not set
Princess Margaret Hospital, Kowloon, Kowloon City
Pamela Youde Nethersole Eastern Hospital, Hong Kong, Not set
Queen Elizabeth Hospital (QEH), Hong Kong, Not set
Queen Mary Hospital - PPDS, Hong Kong, Not set
Tuen Mun Hospital, Hong Kong, Not set
Prince of Wales Hospital, Sha Tin, Not set
Soroka University Medical Centre, Beer Sheva, Not set
Sheba Medical Center - PPDS, Ramat Gan, Not set
AORN Dei Colli- Ospedale Monaldi Napoli, Napoli, Campania
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l - PPDS, Meldola, Forli-Cesena
Istituto Nazionale Dei Tumori, Milano, Lombardia
Instituto Europeo Di Oncologia, Milano, Lombardia
Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano, Piemonte
Centro Di Riferimento Oncologico, Aviano, Pordenone
Azienda Ospedaliero Universitaria Pisana, Pisa, Toscana
Azienda Ospedaliero Universitaria di Parma, Parma, Not set
Ospedale Santa Maria Delle Croci, Ravenna, Not set
Fujita Health University Hospital, Toyoake-Shi, Aiti
Ehime University Hospital, Matsuyama-Shi, Ehime
National Hospital Organization Hokkaido Cancer Center, Sapporo-Shi, Hokkaido
Kurume University Hospital, Kurume-Shi, Hukuoka
Kanagawa Cancer Center, Yokohama-Shi, Kanagawa
Saiseikai Kumamoto Hospital, Kumamoto-Shi, Kumamoto
Miyagi Cancer Center, Natori-Shi, Miyagi
Okayama University Hospital, Okayama-Shi, Okayama
Osaka International Cancer Institute, Chuo Ku, Osaka
Saitama Cancer Center, Komoro, Saitama
National Cancer Center Hospital East, Kashiwa-Shi, Tiba
The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Koto-Ku, Tokyo
Chungbuk National University Hospital, Cheongju-si, Chungcheongbugdo
Pusan National University Hospital, Busan, Not set
National Cancer Center, Goyang, Not set
Chonnam National University Hwasun Hospital, Jeongnam, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center - PPDS, Seoul, Not set
Samsung Medical Center PPDS, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System - PPDS, Seoul, Not set
VU Medisch Centrum, Amsterdam, Noord-Holland
Centro Hospitalar do Porto Hospital de Santo Antonio, Santa Maria Da Feira, Aveiro
Hospital Cuf Porto, Vila Nova de Gaia, Porto
Centro Hospitalar de Lisboa Norte E.P.E Hospital Pulido Valente, Lisboa, Not set
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Porto, Not set
Centro Hospitalar de Sao Joao, E.P.E., Porto, Not set
GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology), Saint Petersburg, Leningradskaya Oblast
LLC "EuroCityClinic", Saint Petersburg, Sankt-Peterburg
National Cancer Centre, Singapore, Not set
ICO lHospitalet Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona
Hospital Universitario A Coruna, A Coruna, Not set
Hospital General Universitario de Alicante, Alicante, Not set
Hospital Universitario Vall d'Hebron - PPDS, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
C.H. Regional Reina Sofia - PPDS, Cordoba, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz - PPDS, Madrid, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Karolinska Universitetssjukhuset Solna, Stockholm, Sodermanlands Lan
Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Not set
National Taiwan University Hospital - YunLin Branch, Douliu, Not set
Kaohsiung Medical University - Chung-Ho Memorial Hospital, Kaohsiung, Not set
E-DA hospital, Kaohsiung, Not set
Taichung Veterans General Hospital, Taichung City, Not set
Chi Mei Medical Center, Liouying, Tainan City, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Baskent University Medical Faculty Adana Practice and Research Center, Yuregir, Adana
T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Kadikoy, Istanbul
Ege University Medical Faculty, Bornova, Izmir
SAKARYA University Medical Faculty, Karaman, Sakarya
Hacettepe University Medical Faculty, Ankara, Not set
Trakya University Medical Faculty, Edirne, Not set
Municipal Non-profit Enterprise "City Clinical Hospital # 4" of Dnipro City Council - PPDS, Dnipropetrovsk, Dnipropetrovs'ka Oblast
Communal Non-profit Enterprise Regional Center of Oncology, Kharkiv, Kharkivs'ka Oblast
Private Enterprise Private Manufacturing Company Acinus, Kropyvnytskyi, Not set
University College London Hospitals (UCLH), London, London, City Of
Royal Marsden Hospital - Surrey, Sutton, Surrey
Clatterbridge Centre For Oncology, Bebington, Wirral
Leicester General Hospital, Leicester, Not set
The Christie NHS Foundation Trust - PPDS, Manchester, Not set
Conditions: Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
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