Dexamethasone Treatment Options in United Kingdom

A collection of 187 research studies where Dexamethasone is the interventional treatment. These studies are located in the United Kingdom . Dexamethasone is used for conditions such as Multiple Myeloma, Postoperative Pain and Lymphoma.

Home

United Kingdom

All Treatments

Dexamethasone

Show Filters

Match to Clinical Trials

Access to cutting-edge treatments

Latest clinical trials

Find trials in your area

Start Matching

Filter by Age

Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)

NCT02861573

Recruiting

The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, Cohort C will receive pembrolizumab + enzalutamide, Cohort D will receive pembrolizumab + abiraterone + prednisone Cohort E will receive pembrolizumab+lenvatinib... Read More

Gender:

MALE

Ages:

18 years and above

Trial Updated:

07/31/2025

Locations: Call for Information (Investigational Site 0005), Los Angeles, California +26 locations

Call for Information (Investigational Site 0005), Los Angeles, California

Call for Information (Investigational Site 2041), Aurora, Colorado

Call for Information (Investigational Site 2083), Baltimore, Maryland

Call for Information (Investigational Site 2091), Cleveland, Ohio

Call for Information (Investigational Site 2027), Portland, Oregon

Call for Information (Investigational Site 2094), Portland, Oregon

Call for Information (Investigational Site 0008), Pittsburgh, Pennsylvania

Call for Information (Investigational Site 2065), Charleston, South Carolina

Call for Information (Investigational Site 0019), Myrtle Beach, South Carolina

Call for Information (Investigational Site 0016), Seattle, Washington

MSD Australia, North Ryde, Not set

Merck Canada, Kirkland, Quebec

MSD Denmark, Glostrup, Not set

MSD Finland Oy, Espoo, Not set

MSD France, Paris, Not set

MSD Sharp & Dohme GmbH, München, Not set

MSD Ireland (Human Health) Ltd., Dublin, Not set

MSD Italia S.r.l., Rome, Not set

MSD Comercializadora, S. de R.L. de C.V., Mexico City, Not set

Merck Sharp & Dohme BV, Haarlem, Not set

Merck Sharp & Dohme (New Zealand) Ltd.,, Auckland, Not set

MSD Polska Sp. Z o.o., Warsaw, Not set

Merck Sharp and Dohme de Espana S.A., Madrid, Not set

MSD Sweden, Stockholm, Not set

Merck Sharp & Dohme (I.A.) Corp., Taipei, Not set

Merck Sharp & Dohme Ilaclari Ltd. Sti, Istanbul, Not set

Merck Sharp & Dohme Ltd., London, Not set

Conditions: Metastatic Castration-Resistant Prostate Cancer

Learn More ›

Isatuximab and Iberdomide as Immunotherapy for High Risk in Smouldering Myeloma

NCT06762769

Recruiting

The study will test a new combination of 3 drugs: Isatuximab (Isa), Iberdomide (Iber) and Dexamethasone (Dex), in patients who have intermediate or high risk smouldering myeloma. Smouldering myeloma is an early form of myeloma which may progress to active multiple myeloma, but at a slow rate. Patients with smouldering myeloma do not usually receive any treatment but will have regular check-ups and observation. Some patients have a diagnosis of smouldering myeloma which has a higher risk of progr... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/29/2025

Locations: Barts Health Trust, London, Not set +1 locations

Conditions: Smouldering Myeloma

Learn More ›

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.

NCT06382948

Recruiting

This trial will study a type of advanced breast cancer (ABC) defined as endocrine receptor (ER)-positive/human epidermal growth factor receptor 2(HER2)-negative and estrogen receptor 1 (ESR1)-mutated. Patients will be treated with elacestrant, a compound that acts as a selective estrogen receptor degrader, and everolimus (or placebo), a kinase inhibitor indicated for the treatment of postmenopausal women with advanced hormone receptor-positive, HER2-negative breast cancer. The main purpose of t... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/28/2025

Locations: Medizinische Universität Innsbruck, Innsbruck, Not set +67 locations

Medizinische Universität Innsbruck, Innsbruck, Not set

Ordensklinikum Linz Barmherzige Schwestern, Linz, Not set

Ordination Priv.-Doz. Dr. Michael Hubalek, Schwaz, Not set

Masaryk Memorial Cancer Institute, Brno, Not set

Multiscan Nemocnice Horovice, Hořovice, Not set

Polyclinique Bordeaux Nord Aquitaine, Bordeau, Not set

Centre Georges François Leclerc, Dijon, Not set

CHU Lyon Sud, Lyon, Not set

Hospital prive des Cotes d'Amor, Plérin, Not set

CHU Saint Etienne, Saint-Priest-en-Jarez, Not set

IUCT Oncopole, Toulouse, Not set

Institute de Cancerologie de Lorraine - Nancy, Vandœuvre-lès-Nancy, Not set

MVZ II der Niels Stensen Kliniken, Georgsmarienhütte, Not set

Klinikum Worms - Frauenklinik, Worms, Not set

University General Hospital Alexandroupoli, Alexandroupolis, Not set

251 Air Force General Hospital, Athens, Not set

Aretaeio Hospital, Athens, Not set

Attikon University Hospital, Athens, Not set

Metropolitan General Hospital 4th department, Athens, Not set

University General Hospital of Heraklion, Iraklio, Not set

University General Hospital of Larissa, Larissa, Not set

Metropolitan Hospital Greece 1st department, Piraeus, Not set

EU Interbalkan Medical Center, Thessaloníki, Not set

Ospedali Riuniti Livorno, Livorno, Not set

Instituto Europeo di Oncologia, Milan, Not set

Azienda Ospedaliero- Universitaria Maggiore Della Carita, Novara, Not set

Hospital General Universitario Dr. Balmis (Alicante), Alicante, Not set

Hospital Universitario San Juan de Alicante, Alicante, Not set

Institut Català d' Oncologia Badalona (ICO), Badalona, Not set

Hospital Clínic i Provincial de Barcelona, Barcelona, Not set

Hospital del Mar, Barcelona, Not set

Hospital Universitari Dexeus, Barcelona, Not set

Hospital Universitari Vall D'Hebron, Barcelona, Not set

Hospital Universitario de Basurto, Bilbao, Not set

Hospital Universitario de Burgos, Burgos, Not set

Hospital Provincial de Castellón, Castello de la Plana, Not set

Centro Oncológico de Galicia, Coruña, Not set

Complejo Hospitalario Universitario de Santiago (CHUS), Coruña, Not set

Hospital San Pedro de Alcántara, Cáceres, Not set

Hospital Universitario Clínico San Cecilio de Granada, Granada, Not set

Complejo Hospitalario de Jaén, Jaén, Not set

Hospital Universitario Insular de Gran Canaria, Las Palmas De Gran Canaria, Not set

Hospital Universitario de León, León, Not set

Hospital Universitario Arnau de Vilanova de Lleida, Lleida, Not set

Hospital Beata María Ana, Madrid, Not set

Hospital Universitario Doce de Octubre, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Not set

Hospital Universitario Ramón y Cajal, Madrid, Not set

Hospital Universitario Sanchinarro-START-CIOCC, Madrid, Not set

MD Anderson Cancer Center Madrid, Madrid, Not set

Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Not set

Hospital Universitari Son Espases, Palma De Mallorca, Not set

Hospitalario Universitario de Navarra, Pamplona, Not set

Hospital Quirónsalud Sagrado Corazón, Sevilla, Not set

Hospital Universitario Virgen del Rocío, Sevilla, Not set

Hospital Universitario Virgen Macarena, Sevilla, Not set

Hospital Universitari Sant Joan de Reus, Tarragona, Not set

Hospital Universitario de Canarias, Tenerife, Not set

Hospital Universitario Marqués de Valdecilla, Valdecilla, Not set

Hospital Clínico Universitario de Valencia, Valence, Not set

Hospital Universitario La Ribera - Alzira, Valence, Not set

Consorci Hospital General Universitari de València, Valencia, Not set

Hospital Arnau de Vilanova de Valencia, Valencia, Not set

Hospital Clínico Universitario Lozano Blesa, Zaragoza, Not set

Barts Health NHS Trust, London, Not set

Royal Cornwall Hospital NHS Trust, Truro, Not set

Genesis Cancer Care UK, Waterlooville, Not set

Conditions: Advanced Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, ESR1 Gene Mutation

Learn More ›

Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

NCT06353386

Recruiting

Substudy 01A is part of a larger research study that is testing experimental treatments for metastatic castration-resistant prostate cancer (mCRPC). The larger study is the umbrella study (U01). The goal of substudy 01A is to evaluate the safety and efficacy of opevesostat-based treatment combinations, or as a single agent, in participants with mCRPC. This substudy will have two phases: a safety lead-in phase and an efficacy phase. The safety lead-in phase will be used to evaluate the safety a... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/25/2025

Locations: UCSD Moores Cancer Center ( Site 0039), La Jolla, California +76 locations

UCSD Moores Cancer Center ( Site 0039), La Jolla, California

UCLA Hematology/Oncology - Santa Monica ( Site 0044), Los Angeles, California

University of Miami Hospital and Clinics, Sylvester Cancer Center-Cancer Research Services ( Site 0051), Miami, Florida

University of Maryland-Greenebaum Comprehensive Cancer Center ( Site 0049), Baltimore, Maryland

Rutgers Cancer Institute of New Jersey ( Site 0033), New Brunswick, New Jersey

University Hospitals Cleveland Medical Center ( Site 0043), Cleveland, Ohio

MEDICAL COLLEGE OF WISCONSIN-Cancer Center Clinical Trials Office ( Site 0020), Milwaukee, Wisconsin

Macquarie University-MQ Health Clinical Trials Unit ( Site 0108), Macquarie University, New South Wales

Gallipoli Medical Research Ltd-GMRF CTU ( Site 0107), Greenslopes, Queensland

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0110), Melbourne, Victoria

Jewish General Hospital ( Site 0206), Montreal, Quebec

Centre Hospitalier de l'Université de Montréal ( Site 0200), Montréal, Quebec

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0207), Quebec, Not set

CIDO SpA-Oncology ( Site 0302), Temuco, Biobio

Clinica Universidad Catolica del Maule-Oncology ( Site 0304), Talca, Maule

FALP ( Site 0301), Santiago, Region M. De Santiago

Pontificia Universidad Catolica de Chile ( Site 0303), Santiago, Region M. De Santiago

Bradfordhill ( Site 0300), Santiago, Region M. De Santiago

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0400), Valledupar, Cesar

IMAT S.A.S ( Site 0404), Monteria, Cordoba

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0406), Bogota, Distrito Capital De Bogota

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0402), Bogota, Distrito Capital De Bogota

Fundación Valle del Lili-Oncology CIC ( Site 0403), Cali, Valle Del Cauca

Herlev and Gentofte Hospital ( Site 0501), Copenhagen, Hovedstaden

Aalborg Universitetshospital, Syd ( Site 0503), Aalborg, Nordjylland

Vaasan Keskussairaala ( Site 0603), Vaasa, Pohjanmaa

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 0604), Helsinki, Uusimaa

Docrates Syöpäsairaala ( Site 0602), Helsinki, Uusimaa

Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0700), Strasbourg, Alsace

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 0703), Bordeaux, Aquitaine

Gustave Roussy ( Site 0701), Villejuif, Ile-de-France

Hôpital Européen Georges Pompidou-Service d'Oncologie Médicale ( Site 0702), Paris, Not set

Universitaetsklinikum Heidelberg ( Site 0805), Heidelberg, Baden-Wurttemberg

Universitaetsklinikum Tuebingen-Urologie ( Site 0801), Tübingen, Baden-Wurttemberg

klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0802), Munich, Bayern

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0800), Berlin, Not set

Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0804), Hamburg, Not set

St. Vincent's University Hospital ( Site 0901), Dublin 4, Dublin

Cork University Hospital ( Site 0902), Cork, Not set

Tallaght University Hospital ( Site 0900), Dublin, Not set

Rambam Health Care Campus-Oncology Division ( Site 1002), Haifa, Not set

Rabin Medical Center ( Site 1001), Petah Tikva, Not set

Sheba Medical Center ( Site 1000), Ramat Gan, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1102), Roma, Lazio

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1103), Milan, Lombardia

Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1101), Rozzano, Milano

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma-Oncology Unit ( Site 1100), Verona, Veneto

Toho University Sakura Medical Center ( Site 1201), Sakura, Chiba

Yokohama City University Medical Center ( Site 1203), Yokohama, Kanagawa

The Jikei University Hospital ( Site 1202), Mitato, Tokyo

Kyushu University Hospital ( Site 1204), Fukuoka, Not set

Asan Medical Center-Oncology ( Site 1500), Songpagu, Seoul

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1502), Seoul, Not set

Samsung Medical Center-Division of Hematology/Oncology ( Site 1501), Seoul, Not set

Auckland City Hospital ( Site 1333), Auckland, Not set

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1402), Bydgoszcz, Kujawsko-pomorskie

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Oddzial Badan Wczesnych Faz ( Site 1400), Warszawa, Mazowieckie

Uniwersyteckie Centrum Kliniczne ( Site 1405), Gdansk, Pomorskie

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 1603), L Hospitalet, Barcelona

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1600), Madrid, Madrid, Comunidad De

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1602), Barcelona, Not set

Hospital General Universitario Gregorio Marañón ( Site 1601), Madrid, Not set

Hospital Clinico San Carlos-Oncology Department ( Site 1604), Madrid, Not set

Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 1704), Kaohsiung Niao Sung Dist, Kaohsiung

China Medical University Hospital ( Site 1703), Taichung, Not set

Taipei Veterans General Hospital ( Site 1701), Taipei, Not set

Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1702), Taoyuan, Not set

Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1802), Adana, Not set

Hacettepe Universite Hastaneleri-oncology hospital ( Site 1800), Ankara, Not set

Ankara Bilkent Şehir Hastanesi ( Site 1801), Ankara, Not set

Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1804), Istanbul, Not set

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1803), Istanbul, Not set

Addenbrooke's Hospital ( Site 1902), Cambridge, Cambridgeshire

The Beatson West of Scotland Cancer Centre ( Site 1904), Glasgow, Glasgow City

Royal Preston Hospital-Lancashire Clinical Research Facility ( Site 1900), Preston, Lancashire

University College London Hospital ( Site 1905), London, London, City Of

Queen Elizabeth Hospital Birmingham ( Site 1903), Birmingham, Warwickshire

Conditions: Prostatic Neoplasms, Castration-Resistant

Learn More ›

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT05730036

Recruiting

This study is researching an experimental drug called linvoseltamab, also called REGN5458. Linvoseltamab has previously been studied by itself (without other cancer drugs) in participants who had advanced multiple myeloma that returned and needed to be treated again after many other therapies had failed. These participants were no longer benefiting from standard medications and had no good treatment options. In that study, some participants who were treated with linvoseltamab had improvement of... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/24/2025

Locations: University of California Los Angeles (UCLA), Los Angeles, California +156 locations

University of California Los Angeles (UCLA), Los Angeles, California

University of Florida Division of Sponsored Programs, Gainesville, Florida

University of Kentucky, Markey Cancer Center Clinical Research Organization, Lexington, Kentucky

Norton Cancer Institute, Louisville, Kentucky

Stony Brook University, Stony Brook, New York

Levine Cancer Center, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

Kaiser Permanente Northwest, Portland, Oregon

MD Anderson Cancer Center, Houston, Texas

University of Washington, Seattle, Washington

Royal Prince Alfred Hospital, Camperdown, New South Wales

Royal North Shore Hospital, St Leonards, New South Wales

Icon Cancer Centre - Wesley, Auchenflower, Queensland

Royal Brisbane and Women's Hospital, Herston, Queensland

Royal Adelaide Hospital, Adelaide, South Australia

Royal Hobart Hospital, Hobart, Tasmania

Launceston General Hospital, Launceston, Tasmania

St Vincent's Hospital, Fitzroy, Victoria

University Hospital Geelong, Geelong, Victoria

Austin Hospital, Heidelberg, Victoria

One Clinical Research at Hollywood Private Hospital, Nedlands, Western Australia

AZ Delta Algemeen Ziekenhuis Delta, Roeselare, West-Vlaanderen

Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerp, Not set

Cliniques Universitaires Saint-Luc, Bruxelles, Not set

Clinique Universitaire de Mont Godinne, Yvoir, Not set

IDOR - Sao Rafael Salvador Bahia, Salvador, Bahia

Hospital Erasto Gaertner, Curitiba, Parana

Associacao Dr Bartholomeu Tacchini, Bento Goncalves, Rio Grande Do Sul

Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Centro Gaucho Integrado, Porto Alegre, Rio Grande Do Sul

Animi Unidade de Tratamento Oncologico, Centro, Not set

Instituto Americas de Ensino e Pesquisa, Rio de Janeiro, Not set

Hospital A Beneficencia Portuguesa de Sao Paulo, Sao Paulo, Not set

Instituto DOr de Pesquisa e Ensino, Sao Paulo, Not set

AC Camargo Cancer Center, Sao Paulo, Not set

Clinica Medica Sao Germano, Sao Paulo, Not set

The Ottawa Hospital Cancer Centre, Ottawa, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

University Health Network-Princess Margaret Cancer Center, Toronto, Ontario

Hospital Clinico Universidad de Los Andes, Santiago, Las Condes

Clinica Alemana de Santiago, Santiago, Region Metropolitana

Fundacion Arturo Lopez Perez, Santiago, Region Metropolitana

Clinica UC San Carlos de Apoquindo, Santiago, Region Metropolitana

Centro Oncologia de Precision Universidad Mayor, Santiago, Region Metropolitana

Centro de Investigaciones Clinicas Vina del Mar, Vina del Mar, Valparaiso

Centre Leon Berard (CLB) - Centre de Recherche en Cancerologie Lyon-Est (CRCL), Lyon, Auvergne-Rhone

Centre Francois Magendie, Pessac, Gironde

Centre Hospitalier Universitaire de Lille, Lille, Hauts De France

Gustave Roussy, Villejuif, Ile De France

Hopital Necker, Paris, Ile-de-France

Hopital Saint Louis, APHP, Paris, Not set

Hopital Saint Antoine, Paris, Not set

Institut Curie, Saint-Cloud, Not set

Medical Clinic II, Tuebingen, Baden-Wuerttemberg

Universitat zu Lubeck Neuromuskulares Zentrum, Luebeck, Ratzeburger

University Hospital Hamburg Eppendorf, Hamburg, Not set

University Hospital Leipzig - Hematology and Cellular Therapy, Leipzig, Not set

Rambam Health Care Campus, Haifa, North

Lady Davis Carmel Medical Center, Haifa, Not set

Shaare Zedek Medical Center, Jerusalem, Not set

Hadassah Medical Center, Jerusalem, Not set

Sheba Medical Center, Ramat Gan, Not set

The Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia

Istituto Romagnolo per lo Studio Dei Tumori Dino Amadori, Meldola, Forli Cesena

A.O.U. Citta della Salute e della Scienza di Torino, Torino, Piemonte

IRCCS Fondazione Piemontese Oncologica Candiolo, Candiolo, Torino

Azienda Ospedaliera Nazionale SS - Antonio e Biagio e Cesare Arrigo, Alessandria, Not set

AOU Ospedali Riuniti di Ancona, Ancona, Not set

Policlinico S. Orsola- Malpighi, Bologna, Not set

Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco", Catania, Not set

Ospedale Policlinico San Martino IRCCS, Genova, Not set

Universita degli Studi di Pavia - Fondazione IRCCS Policlini, Pavia, Not set

Ospedale Santa Maria delle Croci, Ravenna, Not set

AUSL IRCCS OF Reggio Emilia - Clinical Study Location -, Reggio Emilia, Not set

Ospedale di Circolo e Fondazione Macchi Varese, Varese, Not set

Kameda General Hospital, Kamogawa, Chiba

Kurume University Hospital, Kurume, Fukuoka

Ogaki Municipal Hospital, Ogaki, Gifu

Gunma University Hospital, Maebashi, Gunma

NHO Shibukawa Medical Center, Shibukawa, Gunma

Sapporo Hokuyu Hospital, Sapporo, Hokkaido

Iwate Medical University Hospital, Morioka, Iwate

National Hospital Organization Okayama Medical Center, Kita-ku, Okayama

Osaka University Hospital, Suita-shi, Osaka

Saitama Medical University Hospital, Iruma-gun, Saitama

Chiba Cancer Center, Chiba-shi, Tiba

Tokushima Prefectural Central Hospital, Tokushima-shi, Tokushima

Japanese Red Cross Medical Center, Shibuya-ku, Tokyo

Yamanashi Prefectural Central Hospital, Kofu, Yamanashi

Fukushima Medical University, Fukushima, Not set

National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set

National Hospital Organization Sendai Medical Center, Sendai, Not set

Gachon University Gil Hospital, Incheon, Gyeonggi

Jeonbuk National University Hospital, Jeonju, Jeollabuk-do

Chonnam National University Hwasun Hospital, Hwasun, South Jeolla

Inje University Busan Paik Hospital, Busan, Not set

Pusan National University Hospital, Busan, Not set

Asan Medical Center, Seoul, Not set

Seoul St Marys Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Seoul National University Hospital, Seoul, Not set

Severance Hospital, Seoul, Not set

Radboudumc, Nijmegen, Gelderland

Albert Schweitzer Hospital, Dordrecht, Zuid-Holland

Wielospecjalistyczne Centrum Onkologii i Traumatologii, Lodz, Lodzkie

University Clinical Center / Medical University of Gdansk, Gdansk, Pomorskie

Szpital Uniwersytecki Nr2 Bydgoszcz, Bydgoszcz, Not set

Pratia Onkologia Katowice, Katowice, Not set

Centrum Innowacyjnych Terapii Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin, Not set

National University Hospital, Singapore, Not set

Singapore General Hospital, Singapore, Not set

Hospital Clinico Universitario Santiago de Compostela, Santiago de Compostela, A Coruna

Hospital Universitario Araba, Vitoria Gasteiz, Alava

University Hospital of Cabuenes, Gijon, Asturias

Hospital Universitario Central de Asturias, Oviedo, Asturias

Hospital Universitari Son Llatzer, Palma Mallorca, Baleares

Hospital Universitari Son Espases, Palma, Balearic Islands

Institut Catala d'Oncologia, Badalona, Barcelona

Hospital Universitari Mutua Terrassa, Terrassa, Barcelona

Hospital Universitario Marques de Valdecilla, Santander, Cantabria

Complejo Asistencial Universitario de Leon, Leon, Castilla Y Leon

Hospital General Universitario Doctor Balmis Alicante, Alicante, Comunidad Valenciana

Hospital Universitario Puerta de Hierro, Majadahonda, Madrid

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Madrid

Clinica Universidad de Navarra, Pamplona, Navarra

Hospital Universitario de Navarra, Pamplona, Navarra

Universitary Hospital La Princesa, Madrid, Salamanca

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital Sant Pau, Barcelona, Not set

Catalan Institute of Oncology (ICO) Hospitalet, Barcelona, Not set

Instituto Catalan Oncologia, Girona, Not set

Clinica Universidad de Navarra - Madrid, Madrid, Not set

Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Virgen de la Victoria, Malaga, Not set

Hospital Universitario Virgen de Valme, Sevilla, Not set

Hospital Universitari i Politecnic La Fe, Valencia, Not set

Hospital Clinico Lozano Blesa, Zaragoza, Not set

Chang Gung Memorial Hospital - Linkou Branch, Taoyuan, Hunan Province

Changhua Christian Hospital, Changhua City, Not set

Hualien Tzu Chi Hospital, Hualien City, Not set

Kaohsiung Medical University Hospital, Kaohsiung, Not set

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set

Taichung Veterans General Hospital, Taichung, Not set

National Cheng Kung University Hospital, Tainan City, Not set

Wanfang Hospital, Taipei, Not set

National Taiwan University Hospital, Taipei, Not set

Tri-Service General Hospital, Taipei, Not set

Addenbrooke's Hospital, Cambridge, Cambrigeshire

Western General Hospital, Edinburgh, Scotland

Queen Elizabeth Hospital Birmingham, Birmingham, West Midlands

Barts Health NHS Trust, London, Not set

Guy's & St Thomas' NHS Foundation Trust, London, Not set

Royal Marsden Hospital, London, Not set

Hammersmith Hospital, London, Not set

The Christie NHS Foundation Trust, Manchester, Not set

Conditions: Relapsed Refractory Multiple Myeloma (RRMM)

Learn More ›

Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

NCT07096778

Not Yet Recruiting

The purpose of this study is to learn more about the anti-cancer activity of inobrodib, when given in combination with pomalidomide and dexamethasone, in patients with multiple myeloma that has come back following treatment and which no longer responds to available therapies. The study treatment will not be compared to any other treatment and patients will know what treatment they are receiving. This study will also further explore the side effects of inobrodib in combination with these other me... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/24/2025

Locations: Royal Marsden NHS Foundation Trust, Sutton, London

Conditions: Multiple Myeloma Refractory, Multiple Myeloma in Relapse

Learn More ›

A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05083169

Active Not Recruiting

The purpose of this study is to compare the efficacy of teclistamab daratumumab (Tec-Dara) with daratumumab subcutaneously (SC) in combination with pomalidomide and dexamethasone (DPd) or daratumumab SC in combination with bortezomib and dexamethasone (DVd).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/17/2025

Locations: University of Alabama Birmingham, Birmingham, Alabama +173 locations

University of Alabama Birmingham, Birmingham, Alabama

City of Hope, Duarte, California

Stanford University Medical Center, Stanford, California

Yale University, New Haven, Connecticut

Emory University Winship Cancer Institute, Atlanta, Georgia

Tufts Medical Center, Boston, Massachusetts

Henry Ford Hospital, Detroit, Michigan

Ascension Providence Hospital, Southfield, Michigan

Cleveland Clinic, Cleveland, Ohio

West Penn Hospital, Pittsburgh, Pennsylvania

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

Baptist Cancer Center, Memphis, Tennessee

Vanderbilt Ingram Cancer Center, Nashville, Tennessee

University of Texas Southwestern Medical Center, Dallas, Texas

Huntsman Cancer Institute, Salt Lake City, Utah

Fred Hutchinson Cancer Center, Seattle, Washington

University of Wisconsin Carbone Cancer Center, Madison, Wisconsin

Hospital Aleman, Buenos Aires, Not set

Hospital Italiano de Buenos Aires, Buenos Aires, Not set

Hospital Privado Centro Medico de Cordoba, Cordoba, Not set

ZNA Cadix, Antwerpen, Not set

AZ St.-Jan Brugge-Oostende AV, Brugge, Not set

UZ Gent, Gent, Not set

Hopital de Jolimont, Haine Saint Paul La Louviere, Not set

Az Groeninge, Kortrijk, Not set

UZ Leuven, Leuven, Not set

Algemeen Ziekenhuis Delta, Roeselare, Not set

Hospitais Integradaos da Gavea S/A - DF Star, Brasilia, Not set

Liga Paranaense de Combate ao Cancer, Curitiba, Not set

Centro de Pesquisa e Ensino em Oncologia de Santa Catarina CEPEN, Florianopolis, Not set

Liga Norte Riograndense Contra O Cancer, Natal, Not set

Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro, Not set

Hospital Sao Rafael, Salvador, Not set

Real e Benemerita Associacao Portuguesa de Beneficencia, Sao Paulo, Not set

Hospital Paulistano, Sao Paulo, Not set

Clinica Medica Sao Germano S/S LTDA, Sao Paulo, Not set

Instituto D Or de Pesquisa e Ensino IDOR, São Paulo, Not set

Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta

Cross Cancer Institute, Edmonton, Alberta

BC Cancer Agency - Vancouver BC, Vancouver, British Columbia

QEII Health Sciences, Halifax, Nova Scotia

Princess Margaret Cancer Centre University Health Network, Toronto, Ontario

Peking University First Hospital, Beijing, Not set

Peking University People s Hospital, Beijing, Not set

Peking University Third Hospital, Beijing, Not set

The First Hospital of Jilin University, Changchun, Not set

The Third Xiangya Hospital of Central Sourth University, Changshashi, Not set

Beijing Chaoyang Hospital, Chaoyang District, Not set

West China Hospital Sichuan University, Chengdu, Not set

Fujian Meidical University Union Hospital, Fuzhou, Not set

Sun Yat Sen University Cancer Center, Guangzhou, Not set

First affiliated Hospital of Zhejiang University, Hangzhou, Not set

Zhongda Hospital Southeast University, Nanjing, Not set

First Affiliated Hospital of Guangxi Medical University, Nanning, Not set

Shanghai Zhongshan Hospital, Shanghai, Not set

Shengjing Hospital Of China Medical University, Shenyang, Not set

Peking University Shenzhen Hospital, Shenzhen, Not set

Tianjin Medical University General Hospital, Tianjin, Not set

Tianjin Medical University Cancer Institute and Hospital, Tianjin, Not set

The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Not set

The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Not set

Henan Cancer Hospital, Zhengzhou, Not set

Aalborg University Hospital, Aalborg, Not set

Aarhus University Hospital, Aarhus N, Not set

Rigshospitalet, Copenhagen, Not set

Odense Universitets Hospital, Odense, Not set

Vejle Hospital, Vejle, Not set

CHU Henri Mondor, Creteil, Not set

CHRU de Lille Hopital Claude Huriez, LILLE Cedex, Not set

CHU de Limoges Hopital Dupuytren, Limoges, Not set

C.H.U. Hotel Dieu - France, Nantes, Not set

Centre hospitalier Lyon-Sud, Pierre Benite cedex, Not set

CHU De Poitiers, Poitiers, Not set

Institut de Cancerologie Strasbourg Europe ICANS, Strasbourg, Not set

Pôle IUC Oncopole CHU, Toulouse cedex 9, Not set

CHRU Hôpital Bretonneau, Tours, Not set

Universitätsklinikum Carl-Gustav-Carus Dresden, Dresden, Not set

Heinrich-Heine -Universitaet Duesseldorf, Düsseldorf, Not set

Evang. Krankenhaus Essen-Mitte gGmbH, Essen, Not set

Universitatsklinikum Freiburg, Freiburg, Not set

Universitaetsklinikum Hamburg Eppendorf, Hamburg, Not set

St. Barbara-Klinik Hamm GmbH, Hamm, Not set

Universitaetsklinikum Heidelberg, Heidelberg, Not set

Universitaetsklinikum Schleswig Holstein Campus Kiel, Kiel, Not set

Universitaetsklinikum Leipzig, Leipzig, Not set

Universitaetsklinikum Tuebingen, Tubingen, Not set

Alexandra General Hospital of Athens, Athens Attica, Not set

Anticancer Hospital of Thessaloniki Theageneio, Thessaloniki, Not set

G.Papanikolaou, Thessaloniki, Not set

U.O. Ematologia con Trapianto- AOU Policlinico di Bari, Bari, Not set

ASST Papa Giovanni XXIII Bergamo, Bergamo, Not set

Policlinico Sant'Orsola Malpighi, Bologna, Not set

Azienda Ospedaliera Universitaria Careggi, Firenze, Not set

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Not set

IRCCS Policlinico San Matteo, Università degli studi di Pavi, Pavia, Not set

Università di Roma 'La Sapienza' - Ospedale Umberto 1°, Roma, Not set

A.O.U. Citta della Salute e della Scienza di Torino - Presidio Molinette, Turin, Not set

Fukuoka University Hospital, Fukuoka, Not set

Ogaki Municipal Hospital, Gifu, Not set

National Hospital Organization Mito Medical Center, Higashiibaraki-gun, Not set

Tokai University Hospital, Isehara, Not set

Shonan Kamakura General Hospital, Kamakura-shi, Not set

National Cancer Center Hospital East, Kashiwa, Not set

Dokkyo Medical University Saitama Medical Center, Koshigaya, Not set

Kumamoto University Hospital, Kumamoto, Not set

Kurume University Hospital, Kurume, Not set

National Hospital Organization Matsumoto Medical Center, Matsumoto, Not set

Nagoya City University Hospital, Nagoya, Not set

Hyogo Medical University Hospital, Nishinomiya shi, Not set

National Hospital Organization Okayama Medical Center, Okayama, Not set

National Hospital Organization Hiroshima-Nishi Medical Center, Otake, Not set

Hokkaido University Hospital, Sapporo-shi, Not set

National Hospital Organization Sendai Medical Center, Sendai-City, Not set

Tohoku University Hospital, Sendai, Not set

Japanese Red Cross Medical Center, Shibuya-ku, Not set

Iwate Medical University Hospital, Shiwa-gun, Not set

Kyungpook National University Hospital, Daegu, Not set

Gachon University Gil Medical Center, Incheon, Not set

Chonnam National University Hwasun Hospital, Jeollanam-do, Not set

Seoul National University Hospital, Seoul, Not set

Severance Hospital Yonsei University Health System, Seoul, Not set

Samsung Medical Center, Seoul, Not set

The Catholic University of Korea Seoul St Marys Hospital, Seoul, Not set

VU Medisch Centrum, Amsterdam, Not set

Universitair Medisch Centrum Groningen, Groningen, Not set

Sint Antonius Ziekenhuis - Afd.Interne - INT, Nieuwegein, Not set

Radboudumc, Nijmegen, Not set

Isala Kliniek, Zwolle, Not set

Klinika Hematologii i Transplantologii, UCK, Gdansk, Not set

Pratia Onkologia Katowice, Katowice, Not set

Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce, Not set

Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli, Lublin, Not set

Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu, Walbrzych, Not set

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warszawa, Not set

Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu, Wroclaw, Not set

S.P. Botkin Moscow City Clinical Hospital, Moscow, Not set

Clinical Research Institute of Hematology and Transfusiology, St-Petersburg, Not set

Inst. Cat. Doncologia-H Duran I Reynals, Barcelona, Not set

Hosp Univ Vall D Hebron, Barcelona, Not set

Hosp. de Cabuenes, Gijón, Not set

Hosp. Univ. de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Not set

Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set

Hosp. Univ. Ramon Y Cajal, Madrid, Not set

Hosp. Univ. 12 de Octubre, Madrid, Not set

Hosp. Univ. Son Espases, Palma, Not set

Clinica Univ. de Navarra, Pamplona, Not set

Hosp. Quiron Madrid Pozuelo, Pozuelo de Alarcon, Not set

Hosp Clinico Univ de Salamanca, Salamanca, Not set

Hosp. Univ. Marques de Valdecilla, Santander, Not set

Hosp. Clinico Univ. de Santiago, Santiago de Compostela, Not set

Hosp. Virgen Del Rocio, Sevilla, Not set

Hosp. Univ. I Politecni La Fe, Valencia, Not set

Falu Lasarett, Falun, Not set

Sahlgrenska University Hospital, Göteborg, Not set

Helsingborgs lasarett, Helsingborg, Not set

Sunderby Sjukhus, Luleå, Not set

Skanes universitetssjukhus, Lund, Not set

Norrlands Universitetssjukhus, Umea, Not set

Akademiska Sjukhuset, Uppsala, Not set

China Medical University Hospital, Taichung, Not set

National Cheng Kung University Hospital, Tainan, Not set

Chang Gung Memorial Hospital, Taoyuan, Not set

Ankara University Medical Faculty, Ankara, Not set

Ondokuz Mayis University, Atakum, Not set

Medipol University Hospital, Istanbul, Not set

Dokuz Eylul University Medical Faculty, Izmir, Not set

Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, Not set

Ninewells Hospital & Medical School, Dundee, Not set

Kings College Hospital, London, Not set

Oxford University Hospitals NHS Foundation Trust, Oxford, Not set

University Hospitals Plymouth NHS Trust, Plymouth, Not set

Royal Marsden Hospital, Sutton, Not set

Conditions: Multiple Myeloma

Learn More ›

A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy

NCT04923893

Active Not Recruiting

The purpose of this study is to compare the efficacy of Bortezomib, Lenalidomide and Dexamethasone (VRd) induction followed by a single administration of ciltacabtagene autoleucel (cilta-cel) versus VRd induction followed by Lenalidomide and Dexamethasone (Rd) maintenance in newly diagnosed multiple myeloma participants for whom ASCT is not planned as initial therapy in terms of Progression Free Survival (PFS).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/17/2025

Locations: UCSF, San Francisco, California +135 locations

UCSF, San Francisco, California

Yale Cancer Center, New Haven, Connecticut

University of Miami Health System, Miami, Florida

AdventHealth Cancer Institute, Orlando, Florida

University of Iowa Hospitals and Clinics, Iowa City, Iowa

University of Kentucky, Lexington, Kentucky

Norton Cancer Institute, Louisville, Kentucky

University Of Maryland Medical Center, Baltimore, Maryland

Beth Israel Deaconess Medical Center, Boston, Massachusetts

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

Henry Ford Cancer Institute, Detroit, Michigan

Columbia University Medical Center, New York, New York

Memorial Sloan-Kettering Cancer Center, New York, New York

New York Presbyterian-Weill Cornell Medical College, New York, New York

Levine Cancer Institute, Charlotte, North Carolina

Thomas Jefferson University, Philadelphia, Pennsylvania

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

University of Virginia, Charlottesville, Virginia

Medical College Of Wisconsin, Milwaukee, Wisconsin

Hospital Aleman, Buenos Aires, Not set

Hospital Italiano de Buenos Aires, Buenos Aires, Not set

Hospital Privado Universitario De Cordoba, Cordoba, Not set

Royal Prince Alfred Hospital, Camperdown, Not set

St Vincents Hospital Melbourne, Fitzroy, Not set

Austin Health, Heidelberg, Not set

Royal Brisbane and Womens Hospital, Herston, Not set

Alfred Health, Melbourne, Not set

Peter MacCallum Cancer Centre, Melbourne, Not set

Fiona Stanley Hospital, Murdoch, Not set

Calvary Mater Newcastle Hospital, Waratah, Not set

Western Sydney Local Health District, Westmead, Not set

Medizinische Universität Graz, LKH-Univ.Klinikum Graz, Klinische Abteilung für Hämatologie, Graz, Not set

Krankenhaus der Elisabethinen Linz, Linz, Not set

LKH - Universitätsklinikum der PMU Salzburg, Salzburg, Not set

Medical University of Vienna Universitatsklinik fur Innere Medizin I, Vienna, Not set

Universitair Ziekenhuis - Antwerpen, Antwerp, Not set

AZ St.-Jan Brugge-Oostende AV, Brugge, Not set

UZ Gent, Gent, Not set

UZ Leuven, Leuven, Not set

Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman, Liege, Not set

Hospital Sao Rafael, Salvador, Not set

Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, Not set

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, Sao Paulo, Not set

Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta

Vancouver General Hospital, Vancouver, British Columbia

Juravinski Cancer Centre, Hamilton, Ontario

Princess Margaret Cancer Centre University Health Network, Toronto, Ontario

Hopital Maisonneuve Rosemont, Montreal, Quebec

Fakultni nemocnice Brno, Brno, Not set

Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set

Fakultni Nemocnice Ostrava, Ostrava - Poruba, Not set

Vseobecna fakultni nemocnice v Praze, Praha 2, Not set

Aarhus University Hospital, Aarhus C, Not set

Rigshospitalet, Copenhagen, Not set

Odense Universitetshospital, Odense C, Not set

Helsinki University Hospital, Helsinki, Not set

Oulu University Hospital, Oulu, Not set

Turku University Hospital, Turku, Not set

Centre Hospitalier Régional Universitaire de Lille, Hôpital Claude Huriez, Lille Cedex, Not set

C.H.U. Hotel Dieu - France, Nantes, Not set

Hopital Saint Louis, Paris cedex 10, Not set

CHU Poitiers - Hopital la Miletrie, Poitiers, Not set

Institut Universitaire du cancer de Toulouse-Oncopole, Toulouse cedex 9, Not set

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Not set

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden, Not set

Universitatsklinikum Freiburg, Freiburg, Not set

Universitaetsklinikum Hamburg Eppendorf, Hamburg, Not set

Universitaetsklinikum Heidelberg, Heidelberg, Not set

Universitaetsklinikum Leipzig, Leipzig, Not set

Universitatsmedizin der Johannes Gutenberg Universitat Mainz, Mainz, Not set

Klinikum Großhadern der Ludwig-Maximilians-Universität, München, Not set

Universitaetsklinikum Regensburg, Regensburg, Not set

Klinikum der Eberhard Karls Universitaet Abt fur innere Med II Haematologie Onkologie Germany, Tubingen, Not set

Universitatsklinikum Wurzburg, Wuerzburg, Not set

Alexandra General Hospital of Athens, Athens, Not set

Attikon University General Hospital of Attica, Athens, Not set

G.Papanikolaou, Thessaloniki, Not set

Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely, Budapest, Not set

Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set

St James Hospital, Dublin, Not set

Hadassah University Hospita Ein Kerem, Jerusalem, Not set

Sheba Medical Center Tel Hashomer, Ramat Gan, Not set

Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

Juntendo University Hospital, Bunkyo Ku, Not set

Kyushu University Hospital, Fukuoka, Not set

Hyogo Medical University Hospital, Hyôgo, Not set

Kanazawa University Hospital, Kanazawa, Not set

University Hospital Kyoto Prefectural University of Medicine, Kyoto, Not set

Nagoya City University Hospital, Nagoya, Not set

Okayama University Hospital, Okayama, Not set

Hokkaido University Hospital, Sapporo, Not set

Tohoku University Hospital, Sendai, Not set

Japanese Red Cross Medical Center, Shibuya, Not set

Chonnam National University Hwasun Hospital, Jeollanam-do, Not set

Seoul National University Hospital, Seoul, Not set

Severance Hospital Yonsei University Health System, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

The Catholic University of Korea Seoul St Marys Hospital, Seoul, Not set

VU Medisch Centrum, Amsterdam, Not set

University Medical Center Groningen, Groningen, Not set

UMC Radboud, Nijmegen, Not set

Erasmus MC, Rotterdam, Not set

Oslo universitetssykehus HF, Rikshospitalet, Oslo, Not set

Uniwersyteckie Centrum Kliniczne, Gdansk, Not set

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach, Gliwice, Not set

Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli, Lublin, Not set

Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan, Not set

Instytut Hematologii i Transfuzjologii, Warszawa, Not set

Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu, Wroclaw, Not set

Instituto Portugues de Oncologia, Lisboa, Not set

Instituto Portugues de Oncologia, Porto, Not set

Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set

Hosp Univ Vall D Hebron, Barcelona, Not set

Instituto Catalan Deoncologia Hospital Duran I Reynals, L'Hospitalet de Llobregat, Not set

Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set

Hosp. Univ. 12 de Octubre, Madrid, Not set

Hosp. Univ. Virgen de La Arrixaca, Murcia, Not set

Clinica Univ. de Navarra, Pamplona, Not set

Hosp Clinico Univ de Salamanca, Salamanca, Not set

Hosp. Univ. Marques de Valdecilla, Santander, Not set

Hosp. Virgen Del Rocio, Sevilla, Not set

Hosp. Univ. I Politecni La Fe, Valencia, Not set

Sahlgrenska University Hospital, Goteborg, Not set

Universitetssjukhuset, Linköping, Not set

Skane University Hospital, Lund, Not set

Universitatsspital Basel, Basel, Not set

Inselspital Universitatsspital Bern, Bern, Not set

Kantonsspital St Gallen, St. Gallen, Not set

University Hospitals Birmingham NHS Trust,, Birmingham, Not set

Bristol Royal Infirmary, Bristol, Not set

Leeds Teaching Hospitals NHS Trust, Leeds, Not set

University College Hospital, London, Not set

Kings College Hospital, London, Not set

Manchester Royal Infirmary, Manchester, Not set

The Royal Marsden NHS Trust Sutton, Surrey, Not set

Conditions: Multiple Myeloma

Learn More ›

A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT04910568

Active Not Recruiting

This Phase Ib, multicenter, open-label study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cevostamab monotherapy, cevostamab plus pomalidomide and dexamethasone (Pd) or cevostamab plus daratumumab and dexamethasone (Dd) which will be administered to participants with relapsed or refractory multiple myeloma (R/R MM) via intravenous (IV) infusion.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/08/2025

Locations: City of Hope, Duarte, California +27 locations

City of Hope, Duarte, California

City of Hope - Lennar Foundation Cancer Center, Irvine, California

Colorado Blood Cancer Institute (CBCI) at Presbyterian/ St. Luke's Medical Center, Denver, Colorado

Karmanos Cancer Institute., Detroit, Michigan

Washington University School of Medicine, Saint Louis, Missouri

Peter MacCallum Cancer Centre, Melbourne, Victoria

The Alfred Hospital, Melbourne, Victoria

Cross Cancer Institute, Edmonton, Alberta

Hamilton Health Sciences, Hamilton, Ontario

University Health Network, Toronto, Ontario

Fakultni Nemocnice Ostrava, Ostrava, Not set

Rigshospitalet, København Ø, Not set

Hôpital Saint-Louis, Paris, Not set

CHU de Poitiers - La Miletrie, Poitiers, Not set

Rambam Medical Center, Haifa, Not set

Sourasky Medical Centre, Tel-Aviv, Not set

Asst Papa Giovanni Xxiii, Bergamo, Lombardia

A.O. Spedali Civili Di Brescia-P.O. Spedali Civili, Brescia, Lombardia

Yamagata University Hospital, Yamagata, Not set

Seoul National University Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Uniwersyteckie Centrum Kliniczne, Gda?sk, Not set

Pratia Onkologia Katowice, Katowice, Not set

Uniwersytecki Szpital Kliniczny w Poznaniu, Pozna?, Not set

Hospital Universitari Vall d'Hebron, Barcelona, Not set

Hospital General Universitario Gregorio Marañon, Madrid, Not set

University College London Hospitals NHS Foundation Trust, London, Not set

Royal Marsden Hospital, Sutton, Not set

Conditions: Multiple Myeloma

Learn More ›

Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-921/KEYNOTE-921)

NCT03834506

Completed

The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and docetaxel in the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received chemotherapy for mCRPC but have progressed on or are intolerant to Next Generation Hormonal Agent (NHA). There are two primary study hypotheses. Hypothesis 1: The combination of pembrolizumab plus docetaxel plus prednisone is superior to placebo plus docetaxel plus pr... Read More

Gender:

MALE

Ages:

18 years and above

Trial Updated:

07/08/2025

Locations: University of South Alabama, Mitchell Cancer Institute ( Site 0065), Mobile, Alabama +214 locations

University of South Alabama, Mitchell Cancer Institute ( Site 0065), Mobile, Alabama

St. Joseph Heritage Healthcare ( Site 0069), Fullerton, California

University of Southern California Norris Comprehensive Cancer Center ( Site 0061), Los Angeles, California

USC Norris Oncology Hematology Newport Beach ( Site 0093), Newport Beach, California

University of California San Francisco ( Site 0023), San Francisco, California

University of Colorado Cancer Center ( Site 0022), Aurora, Colorado

Yale Cancer Center ( Site 0038), New Haven, Connecticut

Moffitt Cancer Center ( Site 0080), Tampa, Florida

Georgia Cancer Center at Augusta University ( Site 0026), Augusta, Georgia

Mount Sinai Hospital Medical Center ( Site 0042), Chicago, Illinois

Methodist Hospital- Merriillville ( Site 0008), Merrillville, Indiana

Karmanos Cancer Institute ( Site 0077), Detroit, Michigan

Henry Ford Health System ( Site 0039), Detroit, Michigan

Cancer & Hematology Centers of Western Michigan ( Site 0013), Grand Rapids, Michigan

Washington University School of Medicine ( Site 0057), Saint Louis, Missouri

St. Vincent Frontier Cancer Center ( Site 0016), Billings, Montana

Nebraska Cancer Specialists ( Site 0034), Omaha, Nebraska

Comprehensive Cancer Centers of Nevada ( Site 0092), Las Vegas, Nevada

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0004), Hackensack, New Jersey

Associated Medical Professionals of NY ( Site 0060), Syracuse, New York

Duke Cancer Center ( Site 0010), Durham, North Carolina

W. G. Bill Hefner VA Medical Center ( Site 0029), Salisbury, North Carolina

University Hospitals Cleveland Medical Center ( Site 0036), Cleveland, Ohio

Oregon Health Sciences University ( Site 0031), Portland, Oregon

Carolina Urologic Research Center ( Site 0070), Myrtle Beach, South Carolina

Inova Schar Cancer Institute ( Site 0006), Fairfax, Virginia

Virginia Cancer Institute ( Site 0052), Richmond, Virginia

Blue Ridge Cancer Care ( Site 0086), Roanoke, Virginia

Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 1013), Berazategui, Buenos Aires

Instituto de Investigaciones Clinicas ( Site 1000), Mar del Plata, Buenos Aires

Centro de Diagnostico Urologico ( Site 1008), Buenos Aires, Caba

Hospital Britanico de Buenos Aires ( Site 1006), Buenos Aires, Caba

Sanatorio Parque ( Site 1002), Rosario, Santa Fe

Instituto de Investigaciones Metabolicas [Buenos Aires, Argentina] ( Site 1011), Buenos Aires, Not set

Hospital Aleman ( Site 1004), Buenos Aires, Not set

Instituto Medico Alexander Fleming ( Site 1010), Buenos Aires, Not set

CEMAIC ( Site 1014), Cordoba, Not set

St George Hospital ( Site 0157), Kogarah, New South Wales

Macquarie University ( Site 0151), Macquarie University, New South Wales

Port Macquarie Base Hospital ( Site 0153), Port Macquarie, New South Wales

Calvary Mater Newcastle ( Site 0148), Waratah, New South Wales

Redcliffe Hospital ( Site 0161), Redcliffe, Queensland

John Flynn Hospital & Medical Centre ( Site 0164), Tugun, Queensland

Hollywood Private Hospital ( Site 0163), Nedlands, Western Australia

Ordensklinikum Linz GmbH Elisabethinen ( Site 0373), Linz, Oberosterreich

Medizinische Universitat Graz ( Site 0374), Graz, Steiermark

SCRI-CCCIT GesmbH ( Site 0371), Salzburg, Not set

Medizinische Universitaet Wien ( Site 0375), Wien, Not set

Hospital de Caridade de Ijui ( Site 1038), Ijui, Rio Grande Do Sul

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1021), Porto Alegre, Rio Grande Do Sul

Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 1035), Itajai, Santa Catarina

Hospital de Base de Sao Jose de Rio Preto ( Site 1022), Sao Jose do Rio Preto, Sao Paulo

A.C. Camargo Cancer Center ( Site 1026), Sao Paulo, Not set

Nova Scotia Health Authority QEII-HSC ( Site 0114), Halifax, Nova Scotia

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0116), Hamilton, Ontario

Grand River Hospital ( Site 0120), Kitchener, Ontario

Lakeridge Health ( Site 0117), Oshawa, Ontario

Sunnybrook Research Institute ( Site 0108), Toronto, Ontario

Princess Margaret Cancer Centre ( Site 0107), Toronto, Ontario

CIUSSS du Bas Saint Laurent - Hopital Regional de Rimouski ( Site 0102), Rimouski, Quebec

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0105), Sherbrooke, Quebec

CHU de Quebec-Universite Laval-Hotel Dieu de Quebec ( Site 0103), Quebec, Not set

Centro Investigación del Cáncer James Lind ( Site 1041), Temuco, Araucania

Rey y Oreilly Limitada ( Site 1048), Temuco, Araucania

Fundacion Arturo Lopez Perez ( Site 1049), Santiago, Region M. De Santiago

Pontificia Universidad Catolica de Chile ( Site 1047), Santiago, Region M. De Santiago

Bradford Hill Centro de Investigaciones Clinicas ( Site 1044), Santiago, Region M. De Santiago

Centro de Investigaciones Clinicas Vina del Mar ( Site 1042), Vina del Mar, Valparaiso

Peking University First Hospital ( Site 1303), Beijing, Beijing

The Fifth Medical Center of PLA General Hospital ( Site 1307), Beijing, Beijing

Beijing Cancer Hospital ( Site 1305), Beijing, Beijing

The First Affiliated Hospital of Xiamen University ( Site 1319), Xiamen, Fujian

Sun Yat Sen Memorial Hospital ( Site 1323), Guangzhou, Guangdong

The First Affiliated Hospital of Guangzhou Medical University ( Site 1330), Guangzhou, Guangdong

Harbin Medical University Cancer Hospital ( Site 1326), Harbin, Heilongjiang

Henan Cancer Hospital ( Site 1321), Zhengzhou, Henan

Hubei Cancer Hospital ( Site 1329), Wuhan, Hubei

Hunan Cancer Hospital ( Site 1320), Changsha, Hunan

Nanjing Drum Tower Hospital ( Site 1312), Nanjing, Jiangsu

Fudan University Shanghai Cancer Center ( Site 1300), Shanghai, Shanghai

Zhongshan Hospital Fudan University ( Site 1301), Shanghai, Shanghai

The Second Affiliated Hospital of Zhejiang University School of Medicine ( Site 1309), Hangzhou, Zhejiang

Zhejiang Provincial People's Hospital ( Site 1310), Hangzhou, Zhejiang

Hospital Pablo Tobon Uribe ( Site 1066), Medellin, Antioquia

Biomelab S A S ( Site 1067), Barranquilla, Atlantico

Clinica de la Costa Ltda. ( Site 1073), Barranquilla, Atlantico

Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 1068), Valledupar, Cesar

Oncomedica S.A. ( Site 1057), Monteria, Cordoba

Instituto Nacional de Cancerologia E.S.E ( Site 1061), Bogota, Distrito Capital De Bogota

Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 1062), Bogota, Distrito Capital De Bogota

Oncologos del Occidente S.A. ( Site 1072), Pereira, Risaralda

Centro Medico Imbanaco de Cali S.A ( Site 1064), Cali, Valle Del Cauca

Hemato Oncologos S.A. ( Site 1065), Cali, Valle Del Cauca

C.H. de Saint Quentin ( Site 0481), Saint Quentin, Aisne

Clinique Sainte Anne ( Site 0431), Strasbourg, Alsace

Centre Jean Perrin ( Site 0434), Clermont-Ferrand, Auvergne

Centre Leon Berard ( Site 0422), Lyon, Auvergne

Institut Paoli Calmettes. ( Site 0419), Marseille, Bouches-du-Rhone

CHU Jean Minjoz ( Site 0423), Besancon, Doubs

CHU de Brest -Site Hopital Morvan ( Site 0441), Brest, Finistere

Institut Bergonie ( Site 0421), Bordeaux, Gironde

Institut Claudius Regaud IUCT Oncopole ( Site 0418), Toulouse, Haute-Garonne

Hopital Foch ( Site 0428), Suresnes, Hauts-de-Seine

Institut De Cancerologie De L Ouest ( Site 0448), Saint Herblain, Loire-Atlantique

Centre Hospitalier Regional du Orleans ( Site 0430), Orleans, Loiret

Centre D Oncologie de Gentilly ( Site 0432), Nancy, Meurthe-et-Moselle

C.H.U. Lyon Sud ( Site 0436), Pierre Benite, Rhone

CHU Amiens Picardie Site Sud Amiens ( Site 0438), Amiens, Somme

Institut Gustave Roussy ( Site 0416), Villejuif, Val-de-Marne

Institut Sainte Catherine ( Site 0447), Avignon, Vaucluse

Institut Mutualiste Montsouris ( Site 0446), Paris, Not set

Universitaetsklinikum Freiburg - Medizinische Klinik ( Site 0304), Freiburg, Baden-Wurttemberg

Universitaetsklinikum in Mannheim ( Site 0314), Mannheim, Baden-Wurttemberg

Studienpraxis Urologie ( Site 0309), Nuertingen, Baden-Wurttemberg

Universitaetsklinik fuer Urologie ( Site 0307), Tuebingen, Baden-Wurttemberg

Klinikum Rechts der Isar ( Site 0300), Muenchen, Bayern

Universitaetsklinik der Paracelsus Medizinischen Privatuniversitaet ( Site 0318), Nuernberg, Bayern

Universitaetsklinikum Wuerzburg ( Site 0302), Wuerzburg, Bayern

Universitaetsklinikum Goettingen ( Site 0345), Goettingen, Niedersachsen

Uniklinik RWTH Aachen ( Site 0308), Aachen, Nordrhein-Westfalen

Universitaetsklinikum des Saarlandes ( Site 0348), Homburg, Saarland

Universitaetsklinikum Jena ( Site 0305), Jena, Thuringen

Charite Universitaetsmedizin Berlin ( Site 0301), Berlin, Not set

Cork University Hospital ( Site 0727), Cork, Not set

Tallaght University Hospital ( Site 0730), Dublin, Not set

Mid Western Cancer Centre ( Site 0728), Limerick, Not set

Soroka Medical Center ( Site 0548), Beer Sheva, Not set

Assaf Harofeh MC ( Site 0547), Beer Yaakov-Zerifin, Not set

Rambam Medical Center ( Site 0543), Haifa, Not set

Hadassah Ein Kerem Medical Center ( Site 0546), Jerusalem, Not set

Meir Medical Center ( Site 0544), Kfar Saba, Not set

Rabin Medical Center ( Site 0545), Petach-Tikwa, Not set

Chaim Sheba Medical Center ( Site 0541), Ramat Gan, Not set

Sourasky Medical Center ( Site 0542), Tel Aviv, Not set

Istituto Clinico Humanitas Research Hospital ( Site 0452), Rozzano, Milano

Azienda Ospedaliera Cannizzaro ( Site 0458), Catania, Not set

A.O. Universitaria di Modena ( Site 0454), Modena, Not set

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0457), Napoli, Not set

Azienda Ospedaliera San Camillo Forlanini ( Site 0455), Roma, Not set

Azienda Ospedaliera Santa Maria Terni ( Site 0456), Terni, Not set

Presidio Ospedaliero Santa Chiara ( Site 0451), Trento, Not set

National Cancer Center Hospital East ( Site 0702), Kashiwa, Chiba

Toho University Sakura Medical Center ( Site 0703), Sakura, Chiba

National Hospital Organization Shikoku Cancer Center ( Site 0716), Matsuyama, Ehime

Kanazawa University Hospital ( Site 0701), Kanazawa, Ishikawa

Kitasato University Hospital ( Site 0705), Sagamihara, Kanagawa

Yokohama City University Medical Center ( Site 0706), Yokohama, Kanagawa

Nara Medical University Hospital ( Site 0715), Kashihara, Nara

Kindai University Hospital ( Site 0714), Osakasayama, Osaka

Osaka University Hospital ( Site 0713), Suita, Osaka

Saitama Medical University International Medical Center ( Site 0708), Hidaka, Saitama

Dokkyo Medical University Saitama Medical Center ( Site 0707), Koshigaya, Saitama

Hamamatsu University Hospital ( Site 0720), Hamamatsu, Shizuoka

Yamaguchi University Hospital ( Site 0717), Ube, Yamaguchi

Chiba Cancer Center ( Site 0704), Chiba, Not set

Kyushu University Hospital ( Site 0718), Fukuoka, Not set

University of Miyazaki Hospital ( Site 0721), Miyazaki, Not set

Nagasaki University Hospital ( Site 0719), Nagasaki, Not set

Toranomon Hospital ( Site 0711), Tokyo, Not set

Nippon Medical School Hospital ( Site 0709), Tokyo, Not set

Keio University Hospital ( Site 0710), Tokyo, Not set

National Cancer Center ( Site 0174), Goyang-si, Kyonggi-do

Seoul National University Bundang Hospital ( Site 0175), Seongnam-si, Kyonggi-do

Seoul National University Hospital ( Site 0171), Seoul, Not set

Asan Medical Center ( Site 0176), Seoul, Not set

Samsung Medical Center ( Site 0172), Seoul, Not set

Medisch Centrum Leeuwarden ( Site 0477), Leeuwarden, Fryslan

Ziekenhuis Gelderse Vallei ( Site 0485), Ede, Gelderland

Radboud University Medical Center ( Site 0470), Nijmegen, Gelderland

VieCuri Medisch Centrum ( Site 0487), Venlo, Limburg

Jeroen Bosch Ziekenhuis ( Site 1200), Den Bosch, Noord-Brabant

Catharina Ziekenhuis ( Site 0472), Eindhoven, Noord-Brabant

Antoni van Leeuwenhoek Ziekenhuis ( Site 0480), Amsterdam, Noord-Holland

Ziekenhuis Hilversum ( Site 0466), Hilversum, Noord-Holland

Ziekenhuisgroep Twente ( Site 0469), Hengelo, Overijssel

Reinier de Graaf Groep ( Site 0484), Delft, Zuid-Holland

Hagaziekenhuis ( Site 1201), Den Haag, Zuid-Holland

Chelyabinsk Regional Clinical Oncological Dispensary ( Site 0565), Chelyabinsk, Chelyabinskaya Oblast

Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0585), Krasnoyarsk, Krasnoyarskiy Kray

SBIH City clinical hospital named after D.D. Pletniov ( Site 0575), Moscow, Moskva

Russian Scientific Center of Radiology ( Site 0559), Moscow, Moskva

Central Clinical Hospital with Polyclinic ( Site 0562), Moscow, Moskva

National Medical Research Radiological Center ( Site 0556), Moscow, Moskva

Volga District Medical Center Federal Medical and Biological Agency ( Site 0572), Nizhny Novgorod, Nizhegorodskaya Oblast

Omsk Clinical Oncology Dispensary ( Site 0568), Omsk, Omskaya Oblast

SBHI Samara Regional Clinical Oncology Dispensary ( Site 0576), Samara, Samarskaya Oblast

Clinical Research Center of specialized types medical care-Oncology ( Site 0570), Saint Petersburg, Sankt-Peterburg

Russian Scientific Center of Radiology and Surgical Technologies ( Site 0567), Saint Petersburg, Sankt-Peterburg

SPb SBHI City Clinical Oncological Dispensary ( Site 0571), Saint Petersburg, Sankt-Peterburg

Leningrad Regional Oncology Center ( Site 0588), Saint-Petersburg, Sankt-Peterburg

Tomsk National Research Medical Center of Russian Academy of Sciences ( Site 0579), Tomsk, Tomskaya Oblast

Instituto Catalan de Oncologia - ICO ( Site 0330), L Hospitalet De Llobregat, Barcelona

Hospital Consorci Sanitari Parc Tauli ( Site 0335), Sabadell, Barcelona

Hospital Universitario Marques de Valdecilla ( Site 0336), Santander, Cantabria

Hospital Josep Trueta ( Site 0321), Girona, Gerona

Hospital del Mar ( Site 0333), Barcelona, Not set

Hospital Clinic ( Site 0323), Barcelona, Not set

Hospital Universitario Ramon y Cajal ( Site 0328), Madrid, Not set

Hospital Clinico San Carlos ( Site 0324), Madrid, Not set

Hospital Universitario HM Sanchinarro ( Site 0322), Madrid, Not set

Hospital Universitario Virgen de la Victoria ( Site 0337), Malaga, Not set

Hospital Virgen del Rocio ( Site 0329), Sevilla, Not set

National Cheng Kung University Hospital ( Site 0134), Tainen, Tainan

China Medical University Hospital ( Site 0132), Taichung, Not set

Taichung Veterans General Hospital ( Site 0133), Taichung, Not set

National Taiwan University Hospital ( Site 0131), Taipei, Not set

Taipei Veterans General Hospital ( Site 0135), Taipei, Not set

University Hospitals Bristol NHS Foundation Trust ( Site 0530), Bristol, Bristol, City Of

Cambridge University Hospitals NHS Trust ( Site 0540), Cambridge, Cambridgeshire

Torbay Hospital ( Site 0532), Torquay, Devon

Weston Park Hospital ( Site 0539), Sheffield, England

Royal Marsden Hospital ( Site 0526), Sutton, England

Mount Vernon Cancer Centre ( Site 0536), Northwood, Hertfordshire

Barts Cancer Institute ( Site 0483), London, London, City Of

University of North Midlands NHS Foundation Trust ( Site 0527), Stoke-on-Trent, Staffordshire

Conditions: Prostatic Neoplasms

Learn More ›

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT04975997

Active Not Recruiting

This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapsed or refractory multiple myeloma (RRMM).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: Local Institution - 035, Hot Springs, Arkansas +258 locations

Local Institution - 035, Hot Springs, Arkansas

Local Institution - 641, Cerritos, California

Local Institution - 681, Fountain Valley, California

Local Institution - 047, Los Angeles, California

Local Institution - 684, Newport, California

Local Institution - 033, New Haven, Connecticut

Local Institution - 029, Fort Myers, Florida

Local Institution - 693, Ocala, Florida

Local Institution - 028, Saint Petersburg, Florida

Local Institution - 045, Tamarac, Florida

Local Institution - 034, West Palm Beach, Florida

Local Institution - 685, Weston, Florida

Local Institution - 018, Atlanta, Georgia

Local Institution - 640, Elk Grove Village, Illinois

Local Institution - 697, Dyer, Indiana

Local Institution - 040, Louisville, Kentucky

Local Institution - 041, Alexandria, Louisiana

Local Institution - 682, Baton Rouge, Louisiana

Local Institution - 027, Baton Rouge, Louisiana

Local Institution - 698, Baltimore, Maryland

Local Institution - 014, Bethesda, Maryland

Local Institution - 688, Columbia, Maryland

Local Institution - 010, Boston, Massachusetts

Local Institution - 009, Worcester, Massachusetts

Local Institution - 645, Burnsville, Minnesota

Local Institution - 031, Kansas City, Missouri

Local Institution - 046, Billings, Montana

Local Institution - 015, Summit, New Jersey

Local Institution - 691, New York, New York

Local Institution - 039, Durham, North Carolina

Local Institution - 038, Cincinnati, Ohio

Local Institution - 037, Cleveland, Ohio

Local Institution - 008, Cleveland, Ohio

Local Institution - 036, Columbus, Ohio

Local Institution - 680, Tulsa, Oklahoma

Local Institution - 043, Portland, Oregon

Local Institution - 030, Chattanooga, Tennessee

Local Institution - 021, Nashville, Tennessee

Local Institution - 687, Austin, Texas

Local Institution - 695, Houston, Texas

Local Institution - 642, Newport News, Virginia

Local Institution - 643, Roanoke, Virginia

Local Institution - 025, Madison, Wisconsin

Local Institution - 080, Ciudad Autanoma De Buenos Aires, Buenos Aires

Local Institution - 083, Villa Elisa, Buenos Aires

Local Institution - 813, Birtinya, Queensland

Local Institution - 812, Douglas, Queensland

Local Institution - 803, Adelaide, South Australia

Local Institution - 806, Bedford Park, South Australia

Local Institution - 802, Clayton, Victoria

Local Institution - 809, East Melbourne, Victoria

Local Institution - 801, Melbourne, Victoria

Local Institution - 811, Murdoch, Western Australia

Local Institution - 807, West Perth, Western Australia

Local Institution - 804, Camperdown, Not set

Local Institution - 800, Fitzroy, Not set

Local Institution - 808, Garran, Not set

Local Institution - 155, Graz, Not set

Local Institution - 154, Linz, Not set

Local Institution - 153, Salzburg, Not set

Local Institution - 156, St Polten, Not set

Local Institution - 150, Vienna, Not set

Local Institution - 151, Wien, Not set

Local Institution - 172, Brugge, Not set

Local Institution - 174, Bruxelles, Not set

Local Institution - 056, Curitiba, Parana

Local Institution - 058, Porto Alegre, RIO Grande DO SUL

Local Institution - 050, Porto Alegre, RS

Local Institution - 054, Jau, SAO Paulo

Local Institution - 055, Sao Paulo, SP

Local Institution - 051, Barretos, São Paulo

Local Institution - 053, Rio de Janeiro, Not set

Local Institution - 057, Sao Paulo, Not set

Local Institution - 052, Sao Paulo, Not set

Local Institution - 111, Calgary, Alberta

Local Institution - 103, Edmonton, Alberta

Local Institution - 112, Surrey, British Columbia

Local Institution - 104, Saint John, New Brunswick

Local Institution - 110, St John's, Newfoundland and Labrador

Local Institution - 101, Halifax, Nova Scotia

Local Institution - 109, Ottawa, Quebec

Local Institution - 107, Saskatoon, Saskatchewan

Local Institution - 108, Quebec, Not set

Local Institution - 141, Changsha, Hunan

Local Institution - 129, Nanchang, Jiangxi

Local Institution - 143, Xian, Shaanxi

Local Institution - 142, Shanghai, Shanghai

Local Institution - 145, Taiyuan, Shanxi

Local Institution - 144, Wenzhou, Zhejiang

Local Institution - 140, Beijing, Not set

Local Institution - 139, Beijing, Not set

Local Institution - 138, Beijing, Not set

Local Institution - 126, Changchun, Not set

Local Institution - 121, Chaoyang District, Not set

Local Institution - 135, Guangzhou, Not set

Local Institution - 136, Guangzhou, Not set

Local Institution - 128, Hangzhou City, Not set

Local Institution - 120, Hangzhou, Zhejiang, Not set

Local Institution - 127, Harbin, Not set

Local Institution - 134, Nanjing, Not set

Local Institution - 132, Shanghai, Not set

Local Institution - 130, Shanghai, Not set

Local Institution - 131, Shenyang, Not set

Local Institution - 124, Suzhu, Not set

Local Institution - 133, Tianjin, Not set

Local Institution - 137, Wuhan, Not set

Local Institution - 125, Xian, Not set

Local Institution - 123, Zhengzhou, Not set

Local Institution - 601, Brno, Not set

Local Institution - 600, Ostrava-Poruba, Not set

Local Institution - 602, Prague 2, Not set

Local Institution - 371, Aalborg, Not set

Local Institution - 370, Odense, Not set

Local Institution - 372, Roskilde, Not set

Local Institution - 231, Turku, Varsinais-Suomi

Local Institution - 230, Helsinki, Not set

Local Institution - 232, Oulu, Not set

Local Institution - 463, Argenteuil, Not set

Local Institution - 462, La Roche -Sur-Yon - Cedex 9, Not set

Local Institution - 451, Lille Cedex, Not set

Local Institution - 458, Nancy Cedex, Not set

Local Institution - 454, Nantes, Not set

Local Institution - 452, Paris Cedex, Not set

Local Institution - 456, Paris, Not set

Local Institution - 464, Pessac, Not set

Local Institution - 465, Rouen, Not set

Local Institution - 457, Toulouse Cedex 9, Not set

Local Institution - 308, Kiel, Schleswig-Holstein

Local Institution - 301, Frankfurt am Main, Not set

Local Institution - 300, Hamburg, Not set

Local Institution - 302, Hamburg, Not set

Local Institution - 305, Heidelberg, Not set

Local Institution - 304, Lubeck, Not set

Local Institution - 573, Patras, Achaea

Local Institution - 574, Patra, Achaia

Local Institution - 571, Athens, Not set

Local Institution - 572, Thessaloniki, Not set

Local Institution - 570, Thessaloniki, Not set

Local Institution - 932, Hyderabad, Andhra Pradesh

Local Institution - 930, Bangalore, Karnataka

Local Institution - 934, Ernakulam, Kerala

Local Institution - 933, Mumbai, Maharashtra

Local Institution - 935, Kolkata, West Bengal

Local Institution - 931, Pondicherry, Not set

Local Institution - 752, Cork, Not set

Local Institution - 750, Dublin 9, Not set

Local Institution - 751, Galway, Not set

Local Institution - 874, Afula, HaZafon

Local Institution - 872, Haifa, Not set

Local Institution - 871, Jerusalem, Not set

Local Institution - 870, Tel Aviv, Not set

Local Institution - 873, Tel Hashomer, Not set

Local Institution - 415, Roma, Lazio

Local Institution - 400, Bologna, Not set

Local Institution - 408, Catania, Not set

Local Institution - 414, Genova, Not set

Local Institution - 404, Milano, Not set

Local Institution - 410, Novara, Not set

Local Institution - 412, Pavia, Not set

Local Institution - 402, Pisa, Not set

Local Institution - 405, Reggio Calabria, Not set

Local Institution - 401, Roma, Not set

Local Institution - 403, San Giovanni Rotondo FG, Not set

Local Institution - 406, Udine, Not set

Local Institution - 900, Matsuyama, Ehime

Local Institution - 917, Higashi-Ibaraki-gun, Ibaraki

Local Institution - 919, Shimotsuga, Tochigi

Local Institution - 920, Nerima-ku, Tokyo

Local Institution - 918, Shinagawa-ku, Tokyo

Local Institution - 915, Chuo-shi, Yamanashi

Local Institution - 912, Aomori, Not set

Local Institution - 916, Chiba, Not set

Local Institution - 911, Fukuoka, Not set

Local Institution - 903, Kamogawa, Not set

Local Institution - 902, Kyoto-City, Not set

Local Institution - 910, Nagoya, Not set

Local Institution - 901, Nagoya, Not set

Local Institution - 905, Okayama, Not set

Local Institution - 908, Osaka-Sayama, Not set

Local Institution - 907, Osaka, Not set

Local Institution - 913, Sapporo, Not set

Local Institution - 914, Sendai, Not set

Local Institution - 906, Shibuya-ku, Not set

Local Institution - 909, Shinagawa-ku, Tokyo, Not set

Local Institution - 904, Toyohashi, Not set

Local Institution - 974, Daegu, Not set

Local Institution - 973, Gyeonggi-do, Not set

Local Institution - 975, Hwasun-gun, Not set

Local Institution - 971, Seoul, Not set

Local Institution - 976, Seoul, Not set

Local Institution - 972, Seoul, Not set

Local Institution - 970, Seoul, Not set

Local Institution - 977, Seoul, Not set

Local Institution - 183, Guadalajara, Jalisco

Local Institution - 351, Dordrecht, Zuid-Holland

Local Institution - 354, Amsterdam, Not set

Local Institution - 352, Den Haag, Not set

Local Institution - 202, Bergen, Not set

Local Institution - 200, Oslo, Not set

Local Institution - 201, Trondheim, Not set

Local Institution - 631, Bialystok, Podlaskie

Local Institution - 633, Krakow, Not set

Local Institution - 635, Nowy Sacz, Not set

Local Institution - 634, Poznan, Not set

Local Institution - 636, Walbrzych, Not set

Local Institution - 630, Warszawa, Not set

Local Institution - 545, Coimbra, Not set

Local Institution - 543, Lisboa, Not set

Local Institution - 544, Lisboa, Not set

Local Institution - 540, Porto, Not set

Local Institution - 541, Porto, Not set

Local Institution - 514, Pamplona, Navarra

Local Institution - 505, Barcelona, Not set

Local Institution - 502, Barcelona, Not set

Local Institution - 511, Barcelona, Not set

Local Institution - 501, Caceres, Not set

Local Institution - 509, Cordoba, Not set

Local Institution - 510, Madrid, Not set

Local Institution - 516, Madrid, Not set

Local Institution - 504, Madrid, Not set

Local Institution - 513, Madrid, Not set

Local Institution - 503, Malaga, Not set

Local Institution - 508, Murcia, Not set

Local Institution - 506, Oviedo, Not set

Local Institution - 515, Salamanca, Not set

Local Institution - 500, Santiago de Compostela, Not set

Local Institution - 512, Valencia, Not set

Local Institution - 507, Zaragoza, Not set

Local Institution - 272, Boras, Not set

Local Institution - 271, Helsingborg, Not set

Local Institution - 851, Chur, Not set

Local Institution - 850, St. Gallen, Not set

Local Institution - 955, Niao-Sung Hsiang Kaohsiung County, Not set

Local Institution - 952, Taichung City, Not set

Local Institution - 954, Taichung, Not set

Local Institution - 951, Tainan, Taiana, Not set

Local Institution - 956, Taipei, Zhongzheng Dist., Not set

Local Institution - 950, Taipei, Not set

Local Institution - 953, Taoyuan City, Not set

Local Institution - 778, Kavaklıdere, Ankara

Local Institution - 776, Yenimahalle, Ankara

Local Institution - 777, Pendik, Istanbul

Local Institution - 771, Balçova, Izmir

Local Institution - 775, Bornova, Izmir

Local Institution - 773, Samsun, Kurupelit

Local Institution - 770, Ankara, Not set

Local Institution - 772, Gaziantep, Not set

Local Institution - 774, Kayseri, Not set

Local Institution - 702, Nottingham, Nottinghamshire

Local Institution - 705, Belfast Northern Ireland, Not set

Local Institution - 700, Birmingham, Not set

Local Institution - 707, Canterbury Kent, Not set

Local Institution - 704, Lancashire Blackpool, Not set

Local Institution - 701, London, Not set

Local Institution - 709, London, Not set

Local Institution - 706, Oxford, Not set

Local Institution - 711, Portsmouth, Not set

Local Institution - 713, Sutton, Not set

Local Institution - 708, Wolverhampton, Not set

Conditions: Multiple Myeloma

Learn More ›

A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma

NCT06988488

Not Yet Recruiting

The purpose of this study is to evaluate the preliminary safety and determine the RP2D of mezigdomide in combination with elranatamab in participants with relapsed and refractory multiple myeloma (RRMM).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: Local Institution - 0001, Birmingham, Alabama +21 locations

Conditions: Multiple Myeloma

Learn More ›