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Dexamethasone Treatment Options in United Kingdom
A collection of 187 research studies where Dexamethasone is the interventional treatment. These studies are located in the United Kingdom . Dexamethasone is used for conditions such as Multiple Myeloma, Postoperative Pain and Lymphoma.
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Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
Active Not Recruiting
Primary Objectives:
* Safety run-in Part: To confirm the recommended dose of isatuximab when combined with lenalidomide and dexamethasone in participants with high-risk smoldering multiple myeloma (SMM)
* Randomized Phase 3 Part: To demonstrate the clinical benefit of isatuximab in combination with lenalidomide and dexamethasone in the prolongation of progression-free survival when compared to lenalidomide and dexamethasone in subjects with high-risk SMM
Secondary Objectives:
Safety run-in Pa... Read More
Primary Objectives:
* Safety run-in Part: To confirm the recommended dose of isatuximab when combined with lenalidomide and dexamethasone in participants with high-risk smoldering multiple myeloma (SMM)
* Randomized Phase 3 Part: To demonstrate the clinical benefit of isatuximab in combination with lenalidomide and dexamethasone in the prolongation of progression-free survival when compared to lenalidomide and dexamethasone in subjects with high-risk SMM
Secondary Objectives:
Safety run-in Part:
* To assess overall response rate (ORR)
* To assess duration of response (DOR)
* To assess minimal residual disease (MRD) negativity in participants achieving very good partial response (VGPR) or complete response (CR)
* To assess time to diagnostic (SLiM CRAB) progression or death
* To assess time to first-line treatment for multiple myeloma (MM)
* To assess the potential immunogenicity of isatuximab
* Impact of abnormal chromosomal subtype on participant outcome
Randomized Phase 3 Part:
Key Secondary Objectives:
To compare between the arms
* MRD negativity
* Sustained MRD negativity
* Second progression-free survival (PFS2)
* Overall survival
Other Secondary Objectives:
To evaluate in both arms
* CR rate
* ORR
* DOR
* Time to diagnostic (SLiM CRAB) progression
* Time to biochemical progression
* Time to first-line treatment for MM
* Impact of abnormal chromosomal subtype on participant outcome
* Safety and tolerability
* Pharmacokinetics (PK)
* Potential of isatuximab immunogenicity
* Clinical outcome assessments (COAs) Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: UCLA Site Number : 8400010, Los Angeles, California +104 locations
UCLA Site Number : 8400010, Los Angeles, California
Colorado Blood Cancer Institute Site Number : 8400007, Denver, Colorado
Cancer Specialist of North Florida Site Number : 8400011, Jacksonville, Florida
University of Miami Site Number : 8400012, Miami, Florida
Dana Farber Cancer Institute Site Number : 8400001, Boston, Massachusetts
Presbyterian Hospital Site Number : 8400015, Charlotte, North Carolina
Novant Health Forsyth Medical Center Site Number : 8401015, Winston-Salem, North Carolina
Tennessee Oncology Site Number : 8400006, Nashville, Tennessee
~University of Texas - MD Anderson Cancer Center Site Number : 8400002, Houston, Texas
Investigational Site Number :0360008, Liverpool, New South Wales
Investigational Site Number :0360005, Waratah, New South Wales
Investigational Site Number :0360001, Wollongong, New South Wales
Investigational Site Number :0360002, Fitzroy, Victoria
Investigational Site Number :0360007, Heidelberg West, Victoria
Investigational Site Number :0360004, Richmond, Victoria
Investigational Site Number :0360006, Nedlands, Western Australia
Investigational Site Number :0760002, Sao Paulo, São Paulo
Investigational Site Number :1240004, Edmonton, Alberta
Investigational Site Number :1240005, Moncton, New Brunswick
Investigational Site Number :1240001, Montreal, Quebec
Investigational Site Number :1560002, Hangzhou, Not set
Investigational Site Number :1560003, Hangzhou, Not set
Investigational Site Number :1560006, Nanchang, Not set
Investigational Site Number :1560004, Shanghai, Not set
Investigational Site Number :1560005, Shenyang, Not set
Investigational Site Number :1560001, Tianjin, Not set
Investigational Site Number : 2030004, Brno, Not set
Investigational Site Number : 2030005, Hradec Kralove, Not set
Investigational Site Number : 2030002, Olomouc, Not set
Investigational Site Number : 2030003, Ostrava - Poruba, Not set
Investigational Site Number : 2030001, Praha 2, Not set
Investigational Site Number :2080001, Aalborg, Not set
Investigational Site Number :2080003, Aarhus N, Not set
Investigational Site Number :2080005, Copenhagen, Not set
Investigational Site Number :2080002, Roskilde, Not set
Investigational Site Number :2500009, Ars-Laquenexy, Not set
Investigational Site Number :2500010, Bayonne, Not set
Investigational Site Number :2500007, GRENOBLE Cedex 9, Not set
Investigational Site Number :2500006, La Roche sur Yon, Not set
Investigational Site Number :2500003, Lille, Not set
Investigational Site Number :2500005, Paris, Not set
Investigational Site Number :2500011, Paris, Not set
Investigational Site Number :2500002, Poitiers Cedex, Not set
Investigational Site Number :2500001, RENNES Cedex 09, Not set
Investigational Site Number :2760001, Hamburg, Not set
Investigational Site Number :2760002, Heidelberg, Not set
Investigational Site Number :3000002, Athens, Not set
Investigational Site Number :3000001, Athens, Not set
Investigational Site Number :3000003, Thessaloniki, Not set
Investigational Site Number :3480003, Budapest, Not set
Investigational Site Number :3480001, Budapest, Not set
Investigational Site Number :3480002, Debrecen, Not set
Investigational Site Number :3480004, Kaposvár, Not set
Investigational Site Number :3720003, Dublin 7, Dublin
Investigational Site Number :3720002, Dublin 8, Dublin
Investigational Site Number :3720001, Dublin 9, Dublin
Investigational Site Number :3760004, Ashdod, Not set
Investigational Site Number :3760001, Jerusalem, Not set
Investigational Site Number :3760002, Jerusalem, Not set
Investigational Site Number :3760005, Petah-Tikva, Not set
Investigational Site Number :3760006, Ramat Gan, Not set
Investigational Site Number :3760003, Tel Aviv, Not set
Investigational Site Number :3800006, Meldola, Forlì-Cesena
Investigational Site Number :3800001, Rozzano, Milano
Investigational Site Number :3800005, Ancona, Not set
Investigational Site Number :3800003, Bologna, Not set
Investigational Site Number :3800002, Terni, Not set
Investigational Site Number :3920002, Nagoya-shi, Aichi
Investigational Site Number :3920006, Kamogawa-shi, Chiba
Investigational Site Number :3920008, Maebashi-shi, Gunma
Investigational Site Number :3920005, Higashiibaraki-gun, Ibaraki
Investigational Site Number :3920003, Okayama-shi, Okayama
Investigational Site Number :3920009, Sunto-gun, Shizuoka
Investigational Site Number :3920001, Shibuya-ku, Tokyo
Investigational Site Number :4100004, Gangnam-gu, Seoul-teukbyeolsi
Investigational Site Number :4100003, Seoul, Seoul-teukbyeolsi
Investigational Site Number :4100001, Seoul, Seoul-teukbyeolsi
Investigational Site Number :4100002, Seoul, Not set
Investigational Site Number :4400001, Vilnius, Not set
Investigational Site Number :5540004, Christchurch, Canterbury
Investigational Site Number :5540001, Hamilton, Waikato
Investigational Site Number :5780002, Bergen, Not set
Investigational Site Number :5780001, Oslo, Not set
Investigational Site Number :6160006, Bydgoszcz, Kujawsko-pomorskie
Investigational Site Number :6160002, Lodz, Lódzkie
Investigational Site Number :6160008, Gdansk, Pomorskie
Investigational Site Number :6160005, Chorzow, Slaskie
Investigational Site Number :7240004, Barcelona, Barcelona [Barcelona]
Investigational Site Number :7240001, Barcelona, Barcelona [Barcelona]
Investigational Site Number :7240006, Pamplona, Navarra
Investigational Site Number :7240002, Valencia, Valenciana, Comunidad
Investigational Site Number :7240005, Madrid, Not set
Investigational Site Number :7240007, Salamanca, Not set
Investigational Site Number :7240003, Zaragoza, Not set
Investigational Site Number :7520001, Göteborg, Not set
Investigational Site Number :7520003, Helsingborg, Not set
Investigational Site Number : 7920005, Ankara, Not set
Investigational Site Number : 7920001, Ankara, Not set
Investigational Site Number : 7920004, Istanbul, Not set
Investigational Site Number : 7920002, Istanbul, Not set
Investigational Site Number : 7920003, Izmir, Not set
Investigational Site Number :8260002, Bournemouth, Hampshire
Investigational Site Number :8260003, London, London, City Of
Investigational Site Number :8260001, Leicester, Not set
Investigational Site Number :8260004, Southampton, Not set
Conditions: Plasma Cell Myeloma
Phase 1/2 Dose Escalation and Efficacy Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies
Completed
Primary Objective:
Phase 1:
To determine the maximum tolerated dose (MTD)/maximum administered dose (MAD) of SAR650984 (Isatuximab).
Phase 2 (stage 1):
To evaluate the activity of single-agent Isatuximab at different doses/schedules and to select dose and regimen to further evaluate the overall response rate (ORR) of Isatuximab as single agent or in combination with dexamethasone.
Phase 2 (stage 2):
To evaluate the activity in terms of overall response rate (ORR) of Isatuximab at the selec... Read More
Primary Objective:
Phase 1:
To determine the maximum tolerated dose (MTD)/maximum administered dose (MAD) of SAR650984 (Isatuximab).
Phase 2 (stage 1):
To evaluate the activity of single-agent Isatuximab at different doses/schedules and to select dose and regimen to further evaluate the overall response rate (ORR) of Isatuximab as single agent or in combination with dexamethasone.
Phase 2 (stage 2):
To evaluate the activity in terms of overall response rate (ORR) of Isatuximab at the selected dose/schedule from stage1, as single agent (ISA arm) and in combination with dexamethasone (ISAdex arm).
Secondary Objectives:
Phase 1:
* To characterize the global safety profile including cumulative toxicities.
* To evaluate the pharmacokinetic (PK) profile of Isatuximab in the proposed dosing schedule(s).
* To assess the pharmacodynamics (PD), immune response, and preliminary disease response.
Phase 2 (stage 1): to evaluate the following objectives for Isatuximab as single agent:
* Safety
* Efficacy as measured by duration of response, clinical benefit rate, progression free survival, overall survival.
Phase 2 (stage 2): to evaluate the following objectives in each arm (ISA and ISAdex):
* Safety
* Efficacy as measured by duration of response, clinical benefit rate, progression free survival, overall survival.
* Participant-reported changes in health-related quality of life, symptoms of multiple myeloma and generic health status.
* Pharmacokinetic profile of Isatuximab.
* Immunogenicity of Isatuximab.
* Investigate the relationship between CD38 receptor density and CD38 receptor occupancy (Stage 1 only) on multiple myeloma cells and parameters of clinical response. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2024
Locations: Mayo Clinic Site Number : 840003, Scottsdale, Arizona +58 locations
Mayo Clinic Site Number : 840003, Scottsdale, Arizona
UCSF MS Center Site Number : 840005, San Francisco, California
Emory University Site Number : 840009, Atlanta, Georgia
University of Chicago Site Number : 840010, Chicago, Illinois
The University Of Michigan Site Number : 840022, Ann Arbor, Michigan
Karmanos Cancer Center Site Number : 840027, Detroit, Michigan
Mayo Clinic of Rochester Site Number : 840018, Rochester, Minnesota
Washington University School of Medicine Site Number : 840013, Saint Louis, Missouri
The Cancer Center At Hackensack University Medical Site Number : 840011, Hackensack, New Jersey
Memorial Sloan-Kettering Cancer Center Site Number : 840014, New York, New York
Duke University Medical College Site Number : 840016, Durham, North Carolina
University of Cincinnati Site Number : 840004, Cincinnati, Ohio
Vanderbilt University Site Number : 840001, Nashville, Tennessee
Huntsman Cancer Institute at the University of Utah Site Number : 840002, Salt Lake City, Utah
Fred Hutchinson Cancer Research Center Site Number : 840012, Seattle, Washington
Medical College of Wisconsin Site Number : 840017, Milwaukee, Wisconsin
Investigational Site Number : 032003, Capital Federal, Buenos Aires
Investigational Site Number : 032002, Ciudad Autonoma de Buenos Aires, Buenos Aires
Investigational Site Number : 032001, Ciudad de Buenos Aires, Buenos Aires
Investigational Site Number : 056001, Antwerpen, Not set
Hospital Mae de Deus Site Number : 076003, Porto Alegre, Rio Grande Do Sul
Hospital de Amor - Hospital do Cancer de Barretos - Fundacao Pio XII Site Number : 076001, Barretos, São Paulo
Clínica São Germano Site Number : 076002, Sao Paulo, São Paulo
Instituto COI de Educacao e Pesquisa Site Number : 076004, Rio De Janeiro, Not set
Investigational Site Number : 152001, Temuco, La Araucanía
Investigational Site Number : 246001, Helsinki, Not set
Investigational Site Number : 246002, Turku, Not set
Investigational Site Number : 250003, Nantes Cedex 01, Not set
Investigational Site Number : 250004, Pierre Benite, Not set
Investigational Site Number : 250001, TOULOUSE Cedex 9, Not set
Investigational Site Number : 300001, Athens, Not set
Investigational Site Number : 376004, Jerusalem, Not set
Investigational Site Number : 376002, Tel HaShomer, Not set
Investigational Site Number : 380001, Bologna, Not set
Investigational Site Number : 380002, Torino, Not set
Investigational Site Number : 484003, San Luis Potosi, San Luis Potosí
Investigational Site Number : 484001, Monterrey, Not set
Investigational Site Number : 604001, Arequipa, Not set
Investigational Site Number : 604002, Lima, Not set
Investigational Site Number : 643002, Moscow, Not set
Investigational Site Number : 643003, Novosibirsk, Not set
Investigational Site Number : 643001, Petrozavodsk, Not set
Investigational Site Number : 643004, Saint-Petersburg, Not set
Investigational Site Number : 724005, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 724007, Badalona, Catalunya [Cataluña]
Investigational Site Number : 724002, Pamplona, Navarra
Investigational Site Number : 724006, Valencia, Valenciana, Comunidad
Investigational Site Number : 724004, Madrid, Not set
Investigational Site Number : 724001, Salamanca, Not set
Investigational Site Number : 724008, Sevilla, Not set
Investigational Site Number : 792002, Ankara, Not set
Investigational Site Number : 792005, Ankara, Not set
Investigational Site Number : 792001, İstanbul, Not set
Investigational Site Number : 792004, Samsun, Not set
Investigational Site Number : 804001, Kyiv, Not set
Investigational Site Number : 804004, Vinnytsia, Not set
Investigational Site Number : 804002, Zaporizhzhya, Not set
Investigational Site Number : 826002, Southampton, Hampshire
Investigational Site Number : 826001, Nottingham, Nottinghamshire
Conditions: Hematological Malignancy
Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma
Active Not Recruiting
This is a Phase 3, randomized, open-label study designed to evaluate safety and efficacy of belantamab mafodotin in combination with bortezomib/dexamethasone (Arm A) versus daratumumab in combination with bortezomib/dexamethasone (Arm B) in the participants with relapsed recurrent multiple myeloma.
This is a Phase 3, randomized, open-label study designed to evaluate safety and efficacy of belantamab mafodotin in combination with bortezomib/dexamethasone (Arm A) versus daratumumab in combination with bortezomib/dexamethasone (Arm B) in the participants with relapsed recurrent multiple myeloma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2024
Locations: GSK Investigational Site, Yuma, Arizona +143 locations
GSK Investigational Site, Yuma, Arizona
GSK Investigational Site, Denver, Colorado
GSK Investigational Site, Fairfield, Connecticut
GSK Investigational Site, Kansas City, Kansas
GSK Investigational Site, Tyler, Texas
GSK Investigational Site, Roanoke, Virginia
GSK Investigational Site, Camperdown, New South Wales
GSK Investigational Site, Liverpool, New South Wales
GSK Investigational Site, St Leonards, New South Wales
GSK Investigational Site, Waratah, New South Wales
GSK Investigational Site, Wollongong, New South Wales
GSK Investigational Site, Benowa, Queensland
GSK Investigational Site, Herston, Queensland
GSK Investigational Site, Ashford, South Australia
GSK Investigational Site, Box Hill, Victoria
GSK Investigational Site, Heidelberg, Victoria
GSK Investigational Site, Melbourne, Victoria
GSK Investigational Site, Murdoch, Western Australia
GSK Investigational Site, Nedlands, Western Australia
GSK Investigational Site, Brussel, Not set
GSK Investigational Site, Bruxelles, Not set
GSK Investigational Site, Gent, Not set
GSK Investigational Site, Roeselare, Not set
GSK Investigational Site, Florianopolis, Not set
GSK Investigational Site, Joinville, Not set
GSK Investigational Site, Natal, Not set
GSK Investigational Site, Porto Alegre, Not set
GSK Investigational Site, Rio de Janeiro, Not set
GSK Investigational Site, SAo Paulo, Not set
GSK Investigational Site, SAo Paulo, Not set
GSK Investigational Site, Edmonton, Alberta
GSK Investigational Site, London, Ontario
GSK Investigational Site, Toronto, Ontario
GSK Investigational Site, Montreal, Quebec
GSK Investigational Site, Quebec City, Quebec
GSK Investigational Site, Beijing, Not set
GSK Investigational Site, Beijing, Not set
GSK Investigational Site, Changchun, Not set
GSK Investigational Site, Guangzhou, Not set
GSK Investigational Site, GuangZhou, Not set
GSK Investigational Site, Hangzhou, Not set
GSK Investigational Site, Jinan, Not set
GSK Investigational Site, Nanjing, Not set
GSK Investigational Site, Shenyang, Not set
GSK Investigational Site, Suzhou, Not set
GSK Investigational Site, Tianjin, Not set
GSK Investigational Site, Zhengzhou, Not set
GSK Investigational Site, Brno, Not set
GSK Investigational Site, Hradec Kralove, Not set
GSK Investigational Site, Ostrava, Not set
GSK Investigational Site, Praha 2, Not set
GSK Investigational Site, Amiens cedex 1, Not set
GSK Investigational Site, Caen cedex 9, Not set
GSK Investigational Site, Nice cedex 3, Not set
GSK Investigational Site, Paris, Not set
GSK Investigational Site, Rennes, Not set
GSK Investigational Site, Duesseldorf, Not set
GSK Investigational Site, Jena, Not set
GSK Investigational Site, Koeln, Not set
GSK Investigational Site, Muenchen, Not set
GSK Investigational Site, Ulm, Not set
GSK Investigational Site, Wuerzburg, Not set
GSK Investigational Site, Alexandroupolis, Not set
GSK Investigational Site, Athens, Not set
GSK Investigational Site, Thessaloniki, Not set
GSK Investigational Site, Jerusalem, Not set
GSK Investigational Site, Kfar Saba, Not set
GSK Investigational Site, Tel Aviv, Not set
GSK Investigational Site, Tel Hashomer, Not set
GSK Investigational Site, Bergamo, Not set
GSK Investigational Site, Bologna, Not set
GSK Investigational Site, Brescia, Not set
GSK Investigational Site, Catania, Not set
GSK Investigational Site, Meldola FC, Not set
GSK Investigational Site, Milano, Not set
GSK Investigational Site, Ravenna, Not set
GSK Investigational Site, Roma, Not set
GSK Investigational Site, Siena, Not set
GSK Investigational Site, Torino, Not set
GSK Investigational Site, Aichi, Not set
GSK Investigational Site, Aichi, Not set
GSK Investigational Site, Aomori, Not set
GSK Investigational Site, Ehime, Not set
GSK Investigational Site, Fukuoka, Not set
GSK Investigational Site, Fukuoka, Not set
GSK Investigational Site, Fukuoka, Not set
GSK Investigational Site, Fukuoka, Not set
GSK Investigational Site, Gifu, Not set
GSK Investigational Site, Gunma, Not set
GSK Investigational Site, Hyogo, Not set
GSK Investigational Site, Kanagawa, Not set
GSK Investigational Site, Kanagawa, Not set
GSK Investigational Site, Kochi, Not set
GSK Investigational Site, Nagano, Not set
GSK Investigational Site, Okayama, Not set
GSK Investigational Site, Osaka, Not set
GSK Investigational Site, Osaka, Not set
GSK Investigational Site, Shizuoka, Not set
GSK Investigational Site, Pusan, Not set
GSK Investigational Site, Seongnam-si Gyeonggi-do, Not set
GSK Investigational Site, Seoul, Not set
GSK Investigational Site, Seoul, Not set
GSK Investigational Site, Ulsan, Not set
GSK Investigational Site, Dordrecht, Not set
GSK Investigational Site, Groningen, Not set
GSK Investigational Site, Christchurch, Not set
GSK Investigational Site, Dunedin, Not set
GSK Investigational Site, Takapuna Auckland, Not set
GSK Investigational Site, Wellington, Not set
GSK Investigational Site, Chorzow, Not set
GSK Investigational Site, Krakow, Not set
GSK Investigational Site, Lodz, Not set
GSK Investigational Site, Lublin, Not set
GSK Investigational Site, Lublin, Not set
GSK Investigational Site, Nowy Sacz, Not set
GSK Investigational Site, Poznan, Not set
GSK Investigational Site, Warszawa, Not set
GSK Investigational Site, Moscow, Not set
GSK Investigational Site, N Novgorod, Not set
GSK Investigational Site, Novosibirsk, Not set
GSK Investigational Site, Saint-Petersburg, Not set
GSK Investigational Site, Samara, Not set
GSK Investigational Site, Saratov, Not set
GSK Investigational Site, St Petersburg, Not set
GSK Investigational Site, Ufa, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Caceres, Not set
GSK Investigational Site, Gijon, Not set
GSK Investigational Site, L'Hospitalet De Llobrega, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, MOstoles Madrid, Not set
GSK Investigational Site, Murcia, Not set
GSK Investigational Site, PamplonaNavarra, Not set
GSK Investigational Site, Pozuelo De AlarcOn Madr, Not set
GSK Investigational Site, Salamanca, Not set
GSK Investigational Site, Bournemouth, Not set
GSK Investigational Site, Cardiff, Not set
GSK Investigational Site, Dundee, Not set
GSK Investigational Site, Leicester, Not set
GSK Investigational Site, London, Not set
GSK Investigational Site, Stoke on Trent, Not set
GSK Investigational Site, Sutton, Not set
Conditions: Multiple Myeloma
Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma
Completed
This Phase 3, 2-arm, randomized, active comparator-controlled, open-label, multicenter study will compare the efficacy and health-related quality of life (HR-QoL) and assess the safety of selinexor plus bortezomib (Velcade) plus low-dose dexamethasone (SVd) versus bortezomib plus low-dose dexamethasone (Vd) in adult patients with RRMM who have received 1 to 3 prior anti-multiple myeloma (MM) regimens. Crossover from the Vd Arm to a treatment that includes selinexor (i.e., SVdX or SdX) will be al... Read More
This Phase 3, 2-arm, randomized, active comparator-controlled, open-label, multicenter study will compare the efficacy and health-related quality of life (HR-QoL) and assess the safety of selinexor plus bortezomib (Velcade) plus low-dose dexamethasone (SVd) versus bortezomib plus low-dose dexamethasone (Vd) in adult patients with RRMM who have received 1 to 3 prior anti-multiple myeloma (MM) regimens. Crossover from the Vd Arm to a treatment that includes selinexor (i.e., SVdX or SdX) will be allowed at the point of IRC-confirmed objective disease progression per the IMWG criteria for patients in the Vd Arm. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: Boca Raton Clinical Research (BRCR) Medical Center, Plantation, Florida +156 locations
Boca Raton Clinical Research (BRCR) Medical Center, Plantation, Florida
Emory University, Atlanta, Georgia
Kaiser Permanente Hawaii, Honolulu, Hawaii
McFarland Clinic, Ames, Iowa
Stormont Vail Health Care (Cotton O'Neil Cancer Center ), Topeka, Kansas
Commonwealth Hematology, Danville, Kentucky
Norton Cancer Institute, Louisville, Kentucky
University of Maryland, Baltimore, Maryland
Central Care Cancer Center, Bolivar, Missouri
The Valley Hospital Luckow Pavilion, Paramus, New Jersey
Mount Sinai, New York, New York
The Cancer Institute at St. Francis Hospital, Roslyn, New York
Novant-Forsyth Memorial Hospital, Winston-Salem, North Carolina
University of Cincinnati Health, Cincinnati, Ohio
Southwest Cancer Center of Oklahoma, Lawton, Oklahoma
Kaiser Permanente Northwest OR, Portland, Oregon
SCOR AnMed Health Cancer Center, Anderson, South Carolina
Prairie Lakes Healthcare, Watertown, South Dakota
Baylor Sammons Cancer Center, Dallas, Texas
University of Texas Southwestern, Dallas, Texas
Calvary Mater Newcastle, Waratah, New South Wales
Royal Brisbane and Women's Hospital, Herston, Queensland
Mater Misericordiae Limited and Mater Medical Research, South Brisbane, Queensland
Gold Coast University Hospital, Southport, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Flinders Medical Centre, Bedford Park, South Australia
St. Vincent's Hospital Melbourne, Fitzroy, Victoria
The Alfred Hospital, Melbourne, Victoria
Medical University Innsbruck, Department of Internal Medicine V (Hematology and Oncology), Innsbruck, Not set
University Hospital Krems, Department of Internal Medicine II, Krems, Not set
Medical University of Vienna, Vienna, Not set
General Hospital Hietzing, Vienna, Not set
Wilhelminen Hospital, Department of Internal Medicine I, Center for Oncology & Hematology, Vienna, Not set
Jules Bordet Institute, Brussels, Not set
UCL Saint-Luc, Brussels, Not set
University Hospital Ghent, Ghent, Not set
General Hospital Delta, Roeselare, Not set
St. Augustinus Hospital, Wilrijk, Not set
University Multiprofile Hospital for Active Treatment, Sveti Georgi Clinic of Clinical Hematology, Plovdiv, Not set
University Multiprofile Hospital for Active Treatment, Sveti Ivan Rilski Clinic of Hematology, Sofia, Not set
Specialized Hospital for Active Treatment of Hematological Diseases, Clinic of Hematology, Dept. of Clinical Hematology, Sofia, Not set
Tom Baker Cancer Center/ Alberta Health Services, Calgary, Alberta
Cross Cancer Institute / University of Alberta, Edmonton, Alberta
Vancouver General Hospital, Vancouver, British Columbia
Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia
North East Cancer Centre Sudbury, Sudbury, Ontario
Princess Margaret Cancer Research, Toronto, Ontario
Maisonneuve-Rosemont Hospital, Montreal, Quebec
Royal Victoria Hospital / McGill University, Montreal, Quebec
L'Hôtel-Dieu de Québec, Quebec City, Quebec
Saskatchewan Cancer Agency-Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Center, Saskatoon, Saskatchewan
General University Hospital in Prague, Praha 2, Prague
University Hopsital Brno, Brno, Not set
University Hospital Hradec Kralove, Hradec Kralove, Not set
University Hospital Olomouc, Olomouc, Not set
University Hospital Ostrava, Dept. of Hematooncology, Ostrava, Not set
University Hospital Kralovske Vinohrady, Clinic of Internal Hematology, Prague, Not set
Necker Children's Hospital, Department of Adult Hematology, Paris, Ile De France
Hospital Center Departmental La Roche-Sur-Yon, La Roche-sur-Yon, Not set
Claude Huriez Hospital, Lille, Not set
South Lyon Hospital Center, Lyon, Not set
Brabois Adults Hospital, University Hospital Center of Nancy, Nancy, Not set
Nantes University Hospital Center, Nantes, Not set
Saint-Louis Hospital, Paris, Not set
Miletrie Hospital, University Hospital Center of Poitiers, Poitiers, Not set
University Hospital Freiburg, Department of Internal Medicine I, Freiburg, Baden-Wuerttemberg
Klinikum Leverkusen gGmbH Medizinisxhe Klinik 3, Leverkusen, North Rhine Westfalia
Group Practice for Hematology and Oncology, Dresden, Saxony
Alexandra General Hospital, Therapeutic Clinic, Athens, Not set
General Hospital of Athens "Evangelismos", Department of Hematology and Lymphoma, Athens, Not set
University General Hospital of Patra, Pátra, Not set
Theageneion Cancer Hospital, Hematology Department, Thessaloníki, Not set
Semmelweis University, 1st Department of Internal Medicine, Budapest, Not set
Integrated Szent Istvan and Szent laszlo Hospital, Department of Hematology and Stem Cell Transplantation, Budapest, Not set
Semmelweis University, 3rd Department of Internal Medicine, Budapest, Not set
Kaposi Mor Teaching Hospital, 2nd Department of Internal Medicine, Kaposvar, Not set
Medical Center of the University of Pecs, Department of Hematology, Pecs, Not set
Regional Cancer Centre, Patna, Bihar
Regional Cancer Centre, Thiruvananthapuram, Kerala
Prince Aly Khan Hospital, Mumbai, Maharashta
Jaslok Hospital and Research Centre, Mumbai, Maharashta
Bhaktivedanta Hospital, Thane, Maharashtra
IMS & SUM Hospital, Bhubaneswar, Odisha
Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, Punjab
Dayanand Medical College & Hospital, Ludhiana, Punjab
Cancer Institute, Chennai, Tamil Nadu
SRM Institute of Medical Sciences, Chennai, Tamil Nadu
Saveetha Medical College Hospital, Chennai, Tamil Nadu
G. Kuppuswamy Naidu Hospital, Coimbatore, Tamil Nadu
Asviratham Speciality Hospital, Madurai, Tamil Nadu
Meenakshi Mission Hospital, Madurai, Tamil Nadu
Yashoda Hospital, Hyderabad, Telengana
King George's Medical University, Lucknow, Uttar Pradesh
Netaji Subhash Chandra Bose Cancer Research Institute, Kolkata, West Bengal
Nil Ratan Sircar (NRS) Medical College, Kolkata, West Bengal
TATA Memorial Centre, Kolkata, West Bengal
Rajiv Gandhi Cancer Hospital, New Delhi, Not set
Barzilai Medical Center, Ashkelon, Not set
Rambam Health Care Campus, Haifa, Not set
Hadassah Medical Center, Jerusalem, Not set
Rabin Medical Center, Petaẖ Tiqwa, Not set
Hospital Santa Maria of Terni, Terni, Umbria
Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Not set
ASST Papa Giovanni XXIII, Bergamo, Not set
Polyclinic S. Orsola-Malpighi, Department of Hematology, Oncology and Laboratory Medicine, Operative Unit of Hematology - Cavo, Bologna, Not set
University Hospital Careggi, Department of Hematology, Florence, Not set
University Hospital San Martino, IRCCA, Dept. of Integrative Cancer Therapies, Operative Unit of Clinical Hematology, Genoa, Not set
Hospital Niguerda Ca Granda, Department of Hematology and Oncology, Hematology Unit, Milan, Not set
Umberto I Polyclinic of Rome, Department of Cellular Biotechnology and Hematology, Hematology Center, Rome, Not set
University Hospital San Giovanni Battista of Turin, Turin, Not set
Jan Biziel University Hospital #2 in Bydgoszcz, Department of Hematology, Bydgoszcz, Not set
Independent Public Healthcare Facility Municipal Hospital Group in Chorzow, Department of Hematology, Chorzow, Not set
University Hospital in Krakow, Teaching Unit of the Hematology Department, Krakow, Not set
Independent Public Teaching Hospital No.1 in Lublin, Department of Hematology-Oncology and Bone Marrow Transplantation, Lublin, Not set
St. John of Dukla Oncology Center of Lublin, Department of Hematology, Lublin, Not set
Military Institute of Medicine, Department of Internal Medicine and Hematology, Warsaw, Not set
Nicolaus Copernicus Memorial Provincial Specialist Hospital in Lodz, Department of Hematology, Łódź, Not set
Hyperclnical MedLife PDR Vulturului Brasov, Hematology Department, Braşov, Not set
Colentina Clinical Hospital, Department of Hematology, Bucharest, Not set
Bucharest University Emergency Hospital, Department of Hematology, Bucharest, Not set
S.P. Botkin City Clinical Hospital, Moscow, Not set
N.A. Semashko Central Clinical Hospital #2 under OJSC Russian Railways, Moscow, Not set
First I.P. Pavlov State Medical University of St. Petersburg, Saint Petersburg, Not set
V.A. Almazov North-West Federal Medical Research Center, Chemotherapy of Oncohematology Diseases and Bone Marrow Transplantation Department #1, Saint Petersburg, Not set
Clinical Center of Serbia, Clinic of Hematology, Belgrade, Not set
Institute of Oncology and Radiology of Serbia, Clinic of Medical Oncology, Belgrade, Not set
Clinical Center Kragujevac, Clinic of Hematology, Kragujevac, Not set
Clinical Center Nis, Clinic of Hematology and Clinical Immunology, Nis, Not set
Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad, Not set
University Hospital of the Canary Islands, La Laguna, Santa Cruz De Tenerife
Catalan Institute of Oncology (ICO) Badalona, Badalona, Not set
University Hospital of Vall d'Hebron, Barcelona, Not set
University Hospital Infanta Leonor, Department of Hematology, Madrid, Not set
University Clinical Hospital of Salamanca, Department of Hematology, Salamanca, Not set
University Hospital Virgen del Rocio (HUVR), Seville, Not set
Cherkasy Regional Oncology Center, Regional Treatment and Diagnostic Hematology Center, Department of Hematology, Cherkasy, Not set
City Clinical Hospital No.4 of Dnipro City Council, City hematology center, Dnipropetrovsk, Not set
BMT Kiev Center, Kiev, Not set
Kiev Cancer Institute, Kiev, Not set
Institute of Blood Pathology and Transfusion Medicine, Department of Hematology with Laboratory Group, Lviv, Not set
Vinnytsia M.I. Pyrohov Regional Clinical Hospital, Department of Hematology, Vinnytsia, Not set
O.F. Herbachevskyi Regional Clinical Hospital, Hematology Department with Intensive Therapy Wards, Zhytomyr, Not set
Belfast Heatlh & Social Care Trust Belfast City Hospital, Belfast, Northern Ireland
NHS Tayside Ninewells Hospital, Dundee, Scotland
Cardiff & Vale University Health Board University Hospital of Wales, Cardiff, Wales
University Hospitals Birmingham NHS Foundation Trust Queen Elizabeth Hospital, Birmingham, Not set
The Leeds Teaching Hospitals NHS Trust St. James University Hospital, Leeds, Not set
University Hospitals of Leicester NHS Trust Royal Leicester Infirmary, Leicester, Not set
Royal Liverpool & Broadgreen University Hospital NHS Trust Royal Liverpool University Hospital, Liverpool, Not set
London North West Healthcare NHS Trust Northwick Park Hospital, London, Not set
University College London, London, Not set
King's College Hospital NHS Foundation Trust, London, Not set
Imperial College Healthcare NHS Trust Hammersmith Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Freeman Hospital, Newcastle Upon Tyne, Not set
The Royal Wolverhampton NHS Trust New Cross Hospital, Wolverhampton, Not set
Conditions: Multiple Myeloma
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
Recruiting
ALLTogether collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several randomised and interventional trials included in the study-design.
ALLTogether collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several randomised and interventional trials included in the study-design. Read Less
Gender:
ALL
Ages:
Between 0 years and 45 years
Trial Updated:
07/11/2024
Locations: L'hôpital Universitaire des enfants Reine Fabiola (Huderf), Brussels, Not set +130 locations
L'hôpital Universitaire des enfants Reine Fabiola (Huderf), Brussels, Not set
Cliniques Universitaires Saint-Luc (UCL), Brussels, Not set
University Hospital Antwerp, Edegem, Not set
University Hospital Ghent, Ghent, Not set
University Hospital Leuven, Dept of Paediatrics, Leuven, Not set
CHC MontLégia, Boulevard Patience et Beaujonc 2, Liège, Not set
CHR de la Citadelle, Liège, Not set
Aalborg University Hospital, Dept of Paediatrics, Aalborg, Not set
Aarhus University Hospital, Aarhus, Not set
Aarhus University Hospital, Child and Adolescent Health, Aarhus, Not set
Rigshospitalet, Dept of Haematology, Copenhagen, Not set
Rigshospitalet, Dept of Paediatrics, Copenhagen, Not set
Odense University Hospital, Dept of Paediatrics, Odense, Not set
North Estonia Medical Centre, Dept of Haematology, Tallinn, Not set
Tallinn Children´s Hospital, Dept of Paediatrics, Tallinn, Not set
Tartu University Hospital, Tartu, Not set
Helsinki University Hospital, Dept of Haematology, Helsinki, Not set
Helsinki University Hospital, Dept of Paediatrics, Helsinki, Not set
Kuopio University Hospital, Dept of Haematology, Kuopio, Not set
Kuopio University Hospital, Dept of Paediatrics, Kuopio, Not set
Oulu University Hospital, Dept of Haematology, Dept of Medicine, Oulu, Not set
Oulu University Hospital, Dept of Paediatrics, Oulu, Not set
Tampere University Hospital, Dept of Haematology, Tampere, Not set
Tampere University Hospital, Dept of Paediatrics, Tampere, Not set
Turku University Hospital, Clinical Haematology and Stem Cell Transplantation Unit, Turku, Not set
Turku University Hospital, Dept of Paediatrics, Turku, Not set
CHU Amiens Groupe Hospitalier Sud, Amiens Cedex 1, Not set
CHU Angers, Angers Cedex 9, Not set
CHRU Besançon, Besancon Cedex 03, Not set
CHU Bordeaux - Groupe Hospitalier Pellegrin, Bordeaux Cedex, Not set
CHRU Brest - Morvan, Brest Cedex, Not set
Centre Hospitalier Universitaire Caen, Caen Cedex 9, Not set
CHU Clermont-Ferrand, Clermont-ferrand, Not set
CHU Dijon Hôpital François Mitterrand, Dijon, Not set
CHU de Grenoble site Nord - Hôpital Albert Michallon, Grenoble Cedex 9, Not set
CHRU de Lille - Hôpital Jeanne de Flandre, Lille Cedex, Not set
Hôpital de la mère et de l'enfant, Limoges, Not set
CHU de Lyon HCL - GH Est-Institut d'hématologie et d'oncologie pédiatrique IHOP, Lyon Cedex 08, Not set
CHU de Marseille - Hôpital de la Timone, Marseille Cedex 5, Not set
CHU de Montpellier - Hôpital Arnaud de Villeneuve, Montpellier Cedex 5, Not set
CHU Nantes-Hôpital enfant-adolescent, Nantes Cedex 01, Not set
CHU Nice - Hôpital l'Archet 2, Nice, Not set
CHU Paris Saint Louis, Paris, Not set
CHU Paris Armand Trousseau, Paris, Not set
CHU Paris - Hôpital Robert Debré, Paris, Not set
CHU Poitiers, Poitiers Cedex 6, Not set
CHU Reims-American Hospital, Reims, Not set
CHU Rennes - Hôpital sud, Rennes Cedex 2, Not set
CHU Rouen, Rouen Cedex, Not set
CHU De La Réunion - Site Nord (Hôpital Félix GUYON), Saint-Denis, Not set
CHU Saint Etienne Hôpital Nord, Saint-Étienne, Not set
CHU Strasbourg -Hôpital de Hautepierre, Strasbourg Cedex, Not set
CHU Toulouse, TOULOUSE Cedex 9, Not set
CHRU Tours- Hôpital Clocheville, Tours, Not set
CHU de Nancy - Hôpital de Brabois Enfant, Vandoeuvre-les-nancy cedex, Not set
Evangelisches Klinikum Bethel, Bielefeld, Not set
Universitätsklinikum Bonn, Bonn, Not set
Klinikum Bremen Mitte, Bremen, Not set
Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set
HELIOS Klinikum Krefeld, Krefeld, Not set
Universitätsmedizin Mainz, Mainz, Not set
Landspitali University Hospital, Children's Hospital, Reykjavík, Not set
Our Lady's Children's Hospital, Dublin, Not set
Children's Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos, Vilnius, Not set
Vilnius University Hospital Santaros Klinikos, Vilnius, Not set
University Medical Center Utrecht, Dept of Hematology, Utrecht, Not set
Princess Máxima Center for Pediatric Oncology, Utrecht, Not set
University Medical Center Utrecht, Utrecht, Not set
Haukeland University Hospital, Dept of Haematology, Bergen, Not set
Haukeland University Hospital, Dept of Paediatrics, Bergen, Not set
Oslo University Hospital, Dept of Haematology, Oslo, Not set
Oslo University Hospital, Dept of paediatric haemato- and oncology, Oslo, Not set
Stavanger University Hospital, Dept of Haematology, Stavanger, Not set
University Hospital North Norway, Dept of Haematology, Tromsø, Not set
University Hospital of North Norway, Dept of Paediatrics, Tromsø, Not set
St. Olavs University Hospital, Dept of Paediatrics, Trondheim, Not set
St. Olavs University Hospital, Dept of Haematology, Trondheim, Not set
Centro Hospitalar e Universitário de Coimbra, EPE - Hospital Pediátrico de Coimbra, Coimbra, Not set
Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisboa, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Sahlgrenska University Hospital, Section for Haematology and coagulation, Gothenburg, Not set
Sahlgrenska University Hospital, Dept of Paediatric Haematology and Oncology, Gothenburg, Not set
Linköping University Hospital, Dept of Haematology, Linköping, Not set
Linköping University Hospital, Dept of Paediatrics, Linköping, Not set
Skåne University Hospital, Dept of Haematology, Lund, Not set
Skåne University Hospital, Dept of Paediatrics, Lund, Not set
Karolinska University Hospital, Dept of Paediatric Oncology and Haematology, Stockholm, Not set
Karolinska University Hospital, Patient area Haematology, Stockholm, Not set
Norrland University Hospital, Dept of Haematology, Umeå, Not set
Norrland University Hospital, Dept of Paediatrics, Umeå, Not set
Uppsala University Hospital, Dept of Haematology, Uppsala, Not set
Uppsala University Hospital, Dept of Paediatric Haematology and Oncology, Uppsala, Not set
Örebro University Hospital, Section for Haematology, Örebro, Not set
Aberdeen Royal Infirmary, Aberdeen, Aberdeen, Not set
Royal Aberdeen Children's Hospital, Aberdeen, Aberdeen, Not set
Royal Belfast Hospital for Sick Children, Belfast, Belfast, Not set
Belfast City Hospital, Belfast, Belfast, Not set
The Queen Elizabeth Hospital, Birmingham, Birmingham, Not set
Birmingham Children's Hospital, Birmingham, Birmingham, Not set
Bristol Royal Hospital for Children / Bristol Haematology and Oncology Centre, Bristol, Not set
Addenbrooke's Hospital, Cambridge, Cambridge, Not set
Noah's Ark Children's Hospital for Wales, Cardiff, Cardiff, Not set
University Hospital of Wales, Cardiff, Cardiff, Not set
Ninewells Hospital, Dundee, Dundee, Not set
Western General Hospital, Edinburgh, Edinburgh, Not set
Royal Hospital for Children and Young People, Edinburgh, Edinburgh, Not set
Beatson West of Scotland Cancer Centre, Glasgow, Glasgow, Not set
Royal Hospital for Children, Glasgow, Glasgow, Not set
Leeds General Infirmary, Leeds, Leeds, Not set
Leeds St James University Hospital, Leeds, Not set
Leicester Royal Infirmary, Leicester, Leicester, Not set
Alder Hey Children's Hospital, Liverpool, Liverpool, Not set
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, Not set
University College London Hospital, London, London, Not set
Great Ormond Street Hospital for Children, London, London, Not set
King's College Hospital, London, Not set
St. Bartholomews Hospital, London, Not set
Royal Manchester Children's Hospital, Manchester, Manchester, Not set
The Christie NHS Foundation Trust (PTC), Manchester, Not set
Royal Victoria Infirmary, Newcastle, Newcastle upon Tyne, Not set
Freeman Hospital, Newcastle, Newcastle, Not set
Nottingham City Hospital, Nottingham, Nottingham, Not set
Nottingham Queen's Medical Centre, Nottingham, Not set
Churchill Hospital, Oxford, Oxford, Not set
John Radcliffe Hospital, Oxford, Oxford, Not set
Derriford Hospital, Plymouth, Not set
Royal Hallamshire Hospital, Sheffield, Sheffield, Not set
Sheffield Children's Hospital, Sheffield, Sheffield, Not set
Southampton General Hospital, Southampton, Southampton, Not set
Royal Stoke University Hospital, Stoke, Stoke, Not set
Royal Marsden Hospital, Sutton, Sutton, Not set
Conditions: Leukemia, Acute Lymphoblastic
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
Recruiting
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia.
The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia.
In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19.
REMAP-COVID is a sub-platform of REMAP-CAP th... Read More
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia.
The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia.
In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19.
REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: University of Florida, Jacksonville, Florida +407 locations
University of Florida, Jacksonville, Florida
Augusta University, Augusta, Georgia
University of Illinois Health, Chicago, Illinois
Tulane Medical Center, New Orleans, Louisiana
University of Michigan, Ann Arbor, Michigan
Memorial Sloan Kettering Cancer Center, New York, New York
Wake Forest Baptist Health, Winston-Salem, North Carolina
The Ohio State University Wexner Medical Center, Columbus, Ohio
Oregon Health and Science University, Portland, Oregon
University of Pittsburgh Medical Centre, Pittsburgh, Pennsylvania
Brown University - Rhode Island Hospital, Providence, Rhode Island
Canberra Hospital, Canberra, Australian Capital Territory
Bankstown-Lidcombe Hospital, Bankstown, New South Wales
Blacktown Hospital, Blacktown, New South Wales
Campbelltown Hospital, Campbelltown, New South Wales
Sutherland Hospital, Caringbah, New South Wales
Concord Hospital, Concord, New South Wales
Dubbo Base Hospital, Dubbo, New South Wales
Northern Beaches Hospital, Frenchs Forest, New South Wales
Nepean Hospital, Kingswood, New South Wales
St. George Hospital, Kogarah, New South Wales
Liverpool Hospital, Liverpool, New South Wales
John Hunter Hospital, Newcastle, New South Wales
Orange Health Service, Orange, New South Wales
St Vincent's Hospital Sydney, Sydney, New South Wales
Prince of Wales Hospital, Sydney, New South Wales
Royal Prince Alfred Hospital, Sydney, New South Wales
Royal North Shore Hospital, Sydney, New South Wales
Wollongong Hospital, Sydney, New South Wales
Wagga Wagga Base Hospital, Wagga Wagga, New South Wales
Westmead Hospital, Westmead, New South Wales
Royal Darwin Hospital,, Darwin, Northern Territory
Sunshine Coast University Hospital, Birtinya, Queensland
The Prince Charles Hospital, Brisbane, Queensland
Mater Hospital Brisbane, Brisbane, Queensland
Princess Alexandra Hospital, Brisbane, Queensland
Caboolture Hospital, Caboolture, Queensland
Queen Elizabeth II Jubilee Hospital, Coopers Plains, Queensland
Logan Hospital, Logan, Queensland
Redcliffe Hospital, Redcliffe, Queensland
Rockhampton Hospital, Rockhampton, Queensland
Gold Coast University Hospital, Southport, Queensland
Toowoomba Hospital, Toowoomba, Queensland
Townsville Hospital, Townsville, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
The Queen Elizabeth Hospital, Adelaide, South Australia
Lyell McEwin Hospital, Adelaide, South Australia
Flinders Medical Centre, Bedford Park, South Australia
Launceston Hospital, Launceston, Tasmania
Ballarat Base Hospital, Ballarat, Victoria
Bendigo Hospital, Bendigo, Victoria
Casey Hospital, Berwick, Victoria
Box Hill Hospital, Box Hill, Victoria
Monash Medical Centre, Clayton, Victoria
Dandenong Hospital, Dandenong, Victoria
Angliss Hospital, Ferntree Gully, Victoria
Footscray Hospital, Footscray, Victoria
University Hosptial Geelong, Geelong, Victoria
The Alfred Hospital, Melbourne, Victoria
Royal Melbourne Hospital, Melbourne, Victoria
St Vincent's Hospital Melbourne, Melbourne, Victoria
Maroondah Hospital, Ringwood East, Victoria
Sunshine Hospital, Sunshine, Victoria
Werribee Mercy Hospital, Werribee, Victoria
St John of God Hospital Midland, Midland, Western Australia
St John of God Hospital Murdoch, Murdoch, Western Australia
Royal Perth Hospital, Perth, Western Australia
Sir Charles Gairdner Hospital, Perth, Western Australia
Fiona Stanley Hospital, Perth, Western Australia
St John of God Subiaco, Subiaco, Western Australia
CHU de Charleroi - Hôpital Civil Marie Curie, Charleroi, Not set
Universitair Ziekenhuis Gent, Gent, Not set
CHU Namur site Godinne, Namur, Not set
Foothills Medical Centre, Calgary, Alberta
Peter Lougheed Centre, Calgary, Alberta
Rockyview General Hospital, Calgary, Alberta
South Health Campus, Calgary, Alberta
Royal Alexandra Hospital, Alberta, Edmonton, Alberta
University of Alberta Hospital, Edmonton, Alberta
Surrey Memorial Hospital, Surrey, British Columbia
St Boniface General Hospital, Winnipeg, Manitoba
Health Sciences Centre Winnipeg, Winnipeg, Manitoba
Grace Hospital, Winnipeg, Manitoba
Dr. Everett Chalmers Regional Hospital, Fredericton, New Brunswick
The Moncton Hospital, Fredericton, New Brunswick
The Saint John General Hospital, Fredericton, New Brunswick
William Osler Health System, Brampton, Ontario
Brantford General Hospital, Brantford, Ontario
Hamilton general Hospital, Hamilton, Ontario
Juravinski Hospital, Hamilton, Ontario
St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Grand River Hospital, Kitchener, Ontario
St Mary's General Hospital, Kitchener, Ontario
The Ottawa Hospital, Ottawa, Ontario
Niagara Health, Saint Catharines, Ontario
Thunder Bay General Hospital, Thunder Bay, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
St. Michael's Hospital Unity Health Toronto, Toronto, Ontario
Mount Sinai Hospital, Toronto, Ontario
Toronto General Hospital, Toronto, Ontario
Toronto Western Hospital, Toronto, Ontario
St Joseph's Health Centre, Toronto, Ontario
CIUSS Chaudieres-Appalaches (Levis), Lévis, Quebec
Hospital Maisonneuve-Rosemont, Montréal, Quebec
Hôpital Fleury, Montréal, Quebec
Centre Hospitalier de l'Universite de Montreal, Montréal, Quebec
McGill University Health Centre, Montréal, Quebec
Hopital du Sacre-Coeur de Montreal, Montréal, Quebec
CHU de Québec - Université Laval, Québec, Quebec
IUCPQ-UL, Québec, Quebec
Centre Hospitalier de l'Université de Sherbrooke, Sherbrooke, Quebec
Regina General Hospital, Saskatoon, Saskatchewan
Universidad de La Sabana, Chía, Cundinamarca
General County Hospital Požega, Požega, Not set
University Hospital Centre Zagreb, Zagreb, Not set
University Hospital for Infectious Diseases, Zagreb, Not set
Fakultní nemocnice Královské Vinohrady, Prague, Not set
Teplice Hospital, Teplice, Not set
Tartu University Hospital, Tartu, Not set
Helsinki University Hospital, Helsinki, Not set
Tampere University Hospital, Tampere, Not set
CH Argenteuil, Argenteuil, Not set
Centre Hospitalier Henri Mondor d'Aurillac, Aurillac, Not set
Beauvais General Hospital, Beauvais, Not set
Hopital Nord Franche-Comte, Belfort, Not set
Ambroise Pare Hospital, Boulogne-Billancourt, Not set
Centre hospitalier Bethune Beuvry, Béthune, Not set
CH de Dax, Dax, Not set
Centre Hospitalier de Dieppe, Dieppe, Not set
CHU Dijon Bourgogne, Dijon, Not set
Hopital Simone Veil Eaubonne, Eaubonne, Not set
Hospital Raymond Poincare, Garches, Not set
CHD Vendee, La Roche-sur-Yon, Not set
Centre Hospitalier Le Mans, Le Mans, Not set
CHU Dupuytren, Limoges, Not set
Centre Hospitalier de Melun, Melun, Not set
Centre Hospitalier Layne - Mont-de-Marsan, Mont-de-Marsan, Not set
Centre Hospitalier des Pays de Morlaix, Morlaix, Not set
CHR d'Orleans, Orléans, Not set
Lariboisiere Hospital, Paris, Not set
Hopital Tenon, Paris, Not set
Nouvel Hopital Civil Strasbourg, Strasbourg, Not set
Hopital de Hautepierre Strasbourg, Strasbourg, Not set
CHRU Tours Hopital Bretonneau, Tours, Not set
Sud Essonne Hospital Etampes, Étampes, Not set
Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie, Berlin, Not set
Vivantes Klinikum Neukölln, Berlin, Not set
Charite Universitätsmedizin Berlin, Berlin, Not set
Vivantes Humboldt-Klinikum, Berlin, Not set
Carl-Thiem-Klinikum Cottbus, Cottbus, Not set
Klinikum Dortmund, Dortmund, Not set
Elisabeth Hospital Essen, Essen, Not set
Universitätsklinikum Frankfurt, Frankfurt, Not set
University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Not set
Universitätsklinikum Jena, Jena, Not set
University Hospital of Cologne, Köln, Not set
University Hospital Leipzig, Leipzig, Not set
Universitätsklinikum Leipzig, Leipzig, Not set
Klinikum rechts der Isar der TU München, München, Not set
Universitätsklinikum Münster, Münster, Not set
Universitäts Klinikum Tübingen, Tübingen, Not set
Universitätsklinikum Würzburg, Würzburg, Not set
Jósa András County Hospital, Nyíregyháza, Not set
Almási Balogh Pál Kórház, Ózd, Not set
Apollo Main Hospital, Chennai, Tamil Nadu
Apollo First Med Hospital, Chennai, Tamil Nadu
Apollo Vanagaram Hospital, Chennai, Tamil Nadu
Apollo Speciality Hospital - OMR, Chennai, Tamil Nadu
Cork University Hospital, Cork, Not set
Beaumont Hospital, Dublin, Not set
St. Vincent's University Hospital, Dublin, Not set
University Hospital Galway, Galway, Not set
University Hospital Waterford, Waterford, Not set
Rambam Medical Center, Haifa, Not set
Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Not set
The Baruch Padeh Medical Center, Poriyya, Not set
AO Spedali Civili di Brescia, Brescia, Not set
Humanitas Research Hospital, Milan, Not set
Ca' Granda Ospedale Maggiore Policlinico, Milan, Not set
IRCCS Ospedale San Raffaele, Milan, Not set
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo, Not set
Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione, Palermo, Not set
Arcispedale S. Maria Nuova, Reggio Emilia, Not set
Ospedale Infermi di Rimini, Rimini, Not set
St Marianna University School of Medicine, Kawasaki, Kanagawa
Yokohama City University Hospital, Yokohama, Kanagawa
St. Marianna University Yokohama City Seibu Hospital, Yokohama, Kanagawa
Saiseikai Kumamoto Hospital, Minami, Kumamoto
Osaka City General Hospital, Osaka, Not set
Nerima Hikarigaoka Hospital, Tokyo, Not set
Tokyo Metropolitan Bokutoh Hospital, Tokyo, Not set
Itabashi Chuo Medical Center, Tokyo, Not set
Tokyo bay Urayasu-Ichikawa Medical Center, Tokyo, Not set
Wakayama Medical University, Wakayama, Not set
Chitwan Medical College, Bharatpur, Not set
Grande International Hospital, Kathmandu, Not set
Hospital for Advanced Medicine and Surgery (HAMS), Kathmandu, Not set
Nepal Mediciti, Kathmandu, Not set
ZGT Almelo, Almelo, Not set
Meander Medisch Centrum, Amersfoort, Not set
OLVG, Amsterdam, Not set
Rijnstate Hospital, Arnhem, Not set
Jeroen Bosch Ziekenhuis, Den Bosch, Not set
Hagaziekenhuis, Den Haag, Not set
Deventer Hospital, Deventer, Not set
Ziekenhuis Gelderse Vallei, Ede, Not set
Maxima Medisch Centrum Eindhoven, Eindhoven, Not set
Martini Hospital Groningen, Groningen, Not set
University Medical Center Groningen, Groningen, Not set
Medisch Centrum Leeuwarden, Leeuwarden, Not set
Leiden University Medical Center, Leiden, Not set
Canisius Wilhelmina Ziekenhuis, Nijmegen, Not set
Radboud University Medical Center, Nijmegen, Not set
Laurentius Hospital, Roermond, Not set
Maasstad Ziekenhuis, Rotterdam, Not set
Bernhoven Hospital, Uden, Not set
University Medical Center Utrecht, Utrecht, Not set
North Shore Hospital, Auckland, Not set
CVICU, Auckland City Hospital, Auckland, Not set
DCCM, Auckland City Hospital, Auckland, Not set
Middlemore Hospital, Auckland, Not set
Christchurch Hospital, Christchurch, Not set
Waikato Hospital, Hamilton, Not set
Taranaki Base Hospital, New Plymouth, Not set
Rotorua Hospital, Rotorua, Not set
Tauranga Hospital, Tauranga, Not set
Wellington Regional Hospital, Wellington, Not set
Whangarei Hospital, Whangarei, Not set
Ziauddin University Hospital Clifton Campus, Karachi, Sindh
Abbasi Shaheed Hospital, Karachi, Sindh
National Institute of Cardiovascular Diseases, Karachi, Karachi, Sindh
South City Hospital, Karachi, Karachi, Sindh
Ziauddin University North Nazimabad Campus, Karachi, Sindh
Centro Hospitalar do Medio Tejo, Abrantes, Not set
Hospital Ocidental, Lisboa, Not set
Hospital Lusíadas Lisbon, Lisboa, Not set
Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes", Bucharest, Not set
King Abdulaziz Medical City, Riyadh, Not set
University Hospital Center Dr Dragiša Mišović, Belgrade, Not set
University Clinical Centre of Serbia, Belgrad, Not set
Clinical Centre of Niš, Niš, Not set
University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Not set
University Medical Centre Maribor, Maribor, Not set
Hospital del Mar, Barcelona, Not set
Hospital Universitario de Jerez, Cadiz, Not set
Reina Sofia University Hospital, Córdoba, Not set
Ramon y Cajal University Hospital, Madrid, Not set
Hospital Regional de Málaga, Málaga, Not set
Hospital Universitario de Ourense, Ourense, Not set
Hospital Marqués de Valdecilla, Santander, Not set
Hospital Verge de la Cinta, Tortosa, Not set
Doctor Peset University Hospital, Valencia, Not set
Hospital La Fe, Valencia, Not set
University Hospital Zürich, Zürich, Not set
Basildon Hospital, Basildon, England
Basingstoke and North Hampshire Hospital, Basingstoke, England
Royal United Hospital, Bath, Bath, England
Queen Elizabeth Hospital Birmingham, Birmingham, England
Birmingham City Hospital, Birmingham, England
Royal Blackburn Teaching Hospital, Blackburn, England
Pilgrim Hospital ULHT, Boston, England
Royal Bournemouth Hospital, Bournemouth, England
Royal Sussex County Hospital, Brighton, England
Southmead Hospital, Bristol, England
Bristol Royal Infirmary, Bristol, England
Queen's Hospital, Burton, Burton on Trent, England
Royal Papworth Hospital, Cambridge, England
Addenbrookes Hospital, Cambridge, England
North Cumberland Infirmary, Carlisle, England
St Peter's Hospital, Chertsey, England
Chesterfield Royal Hospital, Chesterfield, England
Countess of Chester Hospital, Chester, England
Colchester Hospital, Colchester, England
University Hospital Coventry, Coventry, England
Darlington Memorial Hospital, Darlington, England
Darent Valley Hospital, Dartford, England
Russells Hall Hospital, Dudley, England
Royal Devon and Exeter Hospital, Exeter, England
Frimley Park Hospital, Frimley, England
Queen Elizabeth Hospital Gateshead, Gateshead, England
Medway Maritime Hospital, Gillingham, England
James Paget University Hospital, Great Yarmouth, England
Royal Surrey County Hospital, Guildford, England
Northwick Park Hospital, Harrow, England
Hereford County Hospital, Hereford, England
Barnet Hospital, High Barnet, England
Huddersfield Royal Infirmary, Huddersfield, England
King George Hospital, Ilford, England
Ipswich Hospital, Ipswich, England
Kettering Hospital, Kettering, England
Leeds General Infirmary, Leeds, England
Leicester Royal Infirmary, Leicester, England
Glenfield Hospital, Leicester, England
Lincoln County Hospital, Lincoln, England
Liverpool Heart and Chest Hospital, Liverpool, England
Alder Hey Hospital, Liverpool, England
Royal Liverpool University Hospital, Liverpool, England
University Hospital Aintree, Liverpool, England
Croydon University Hospital, London, England
Royal London Hospital, London, England
Whipps Cross Hospital, London, England
Newham University Hospital, London, England
St Bartholomew's Hospital, London, England
North Middlesex University Hospital, London, England
Royal Free Hospital, London, England
St Thomas Hospital, London, England
Guy's Hospital, London, England
Queen Elizabeth Hospital, Woolwich, London, England
King's College Hospital, London, England
St George's University Hospital, London, England
Royal Marsden Hospital, London, England
Royal Brompton Hospital, London, England
Hammersmith Hospital, London, England
St Mary's Hospital, London, England
Charing Cross Hospital, London, England
Luton and Dunstable University Hospital, Luton, England
Maidstone Hospital, Maidstone, England
Manchester Royal Infirmary, Manchester, England
The Christie Hospital, Manchester, England
Wythenshawe Hospital, Manchester, England
North Manchester General Hospital, Manchester, England
The James Cook University Hospital, Middlesbrough, England
Milton Keynes University Hospital, Milton Keynes, England
Royal Victoria Infirmary, Newcastle, Newcastle, England
Newcastle Freeman Hospital, Newcastle, England
Northampton General Hospital, Northampton, England
Norfolk and Norwich University Hospital, Norwich, England
City Hospital Nottingham, Nottingham, England
Queen's Medical Centre - Nottingham University Hospitals NHS Trust, Nottingham, England
George Eliot Hospital, Nuneaton, England
Royal Oldham Hospital, Oldham, England
Princess Royal University Hospital, Orpington, England
John Radcliffe Hospital, Oxford, England
Derriford Hospital, Plymouth, England
Poole Hospital NHS Foundation Trust, Poole, England
Queen Alexandra Hospital, Portsmouth, England
Whiston Hospital, Prescot, England
Royal Preston Hospital, Preston, England
Royal Berkshire Hospital, Reading, England
Alexandra Hospital, Redditch, Redditch, England
Queen's Hospital Romford, Romford, England
Rotherham Hospital, Rotherham, England
Salford Royal Hospital, Salford, England
Salisbury District Hospital, Salisbury, England
Royal Hallamshire Hospital, Sheffield, England
Northern General Hospital, Sheffield, England
Wexham Park Hospital, Slough, England
South Tyneside District Hospital, South Shields, England
Southampton General Hospital, Southampton, England
Stepping Hill Hospital, Stockport, England
University Hospital of North Tees, Stockton-on-Tees, England
Royal Stoke University Hospital, Stoke-on-Trent, England
Sunderland Royal Hospital, Sunderland, England
King's Mill Hospital, Sutton In Ashfield, England
Great Western Hospital, Swindon, England
Western General Hospital, Swindon, England
Musgrove Park Hospital, Taunton, England
Torbay Hospital, Torquay, England
Royal Cornwall Hospital, Truro, England
Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust, Tunbridge Wells, England
Harefield Hospital, Uxbridge, England
Watford General Hospital, Watford, England
Southend Hospital, Westcliff-on-Sea, England
West Cumberland Hospital, Whitehaven, England
Royal Albert Edward Infirmary, Wigan, England
Royal Hampshire County Hospital, Winchester, England
Arrowe Park Hospital, Wirral, England
New Cross Hospital Wolverhampton, Wolverhampton, England
Worcestershire Royal Hospital, Worcester, England
York Teaching Hospital, York, England
Antrim Area Hospital, Antrim, Northern Ireland
Royal Victoria Hospital Belfast, Belfast, Northern Ireland
Mater Hospital, Belfast, Northern Ireland
Belfast City Hospital, Belfast, Northern Ireland
Altnagelvin Hospital, Derry, Northern Ireland
Aberdeen Royal Infirmary, Aberdeen, Scotland
Ninewells Hospital, Dundee, Scotland
Royal Infirmary of Edinburgh, Edinburgh, Scotland
Glasgow Royal Infirmary, Glasgow, Scotland
Queen Elizabeth University Hospital, Glasgow, Glasgow, Scotland
Royal Alexandra Hospital, Paisley, Scotland
Neville Hall Hospital, Abergavenny, Wales
Glan Clwyd Hospital, Bodelwyddan, Wales
Princess of Wales Hospital, Bridgend, Wales
Cardiff and Vale University Hospital Wales, Cardiff, Wales
Glangwilli Hospital, Carmarthen, Wales
Grange University Hospital, Cwmbran, Wales
Royal Gwent Hospital, Newport, Wales
Royal Glamorgan Hospital, Pontyclun, Wales
Morriston Hospital, Swansea, Wales
Wrexham Maelor Hospital, Wrexham, Wales
Ulster Hospital, Belfast, Not set
Bristol Royal Childrens Hospital, Bristol, Not set
Fairfield General Hospital, Bury, Not set
Leighton Hospital, Crewe, Not set
Dorset County Hospital, Dorchester, Not set
Gloucester Royal Hospital, Gloucester, Not set
The Princess Royal Hospital Haywards Heath, Haywards Heath, Not set
St. James University Hospital, Leeds, Not set
Homerton Hospital, London, Not set
University College London Hospital, London, Not set
Chelsea and Westminster Hospital, London, Not set
Queen Elizabeth and Queen Mother Hospital, Margate, Not set
Newcastle Royal Victoria Infirmary (Paediatrics), Newcastle Upon Tyne, Not set
North Tyneside General Hospital, North Shields, Not set
Warwick Hospital, Warwick, Not set
Sandwell General Hospital, West Bromwich, Not set
Conditions: Community-acquired Pneumonia, Influenza, COVID-19
A Study to Determine Dose, Safety, Tolerability, Drug Levels, and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Participants With Multiple Myeloma
Active Not Recruiting
This is a multicenter, multi-country, open-label, Phase 1b/2a dose-escalation study consisting of two parts: dose escalation (Part 1) for CC-220 monotherapy, CC-220 in combination with DEX, CC-220 in combination with DEX and DARA, CC-220 in combination with DEX and BTZ and CC-220 in combination with DEX and CFZ; and the expansion of the RP2D (Part 2) for CC-220 monotherapy and CC-220 in combination with DEX for Relapsed Refractory Multiple Myeloma (RRMM), CC-220 in combination with DEX and BTZ,... Read More
This is a multicenter, multi-country, open-label, Phase 1b/2a dose-escalation study consisting of two parts: dose escalation (Part 1) for CC-220 monotherapy, CC-220 in combination with DEX, CC-220 in combination with DEX and DARA, CC-220 in combination with DEX and BTZ and CC-220 in combination with DEX and CFZ; and the expansion of the RP2D (Part 2) for CC-220 monotherapy and CC-220 in combination with DEX for Relapsed Refractory Multiple Myeloma (RRMM), CC-220 in combination with DEX and BTZ, and CC-220 in combination with DEX and DARA for Newly Diagnosed Multiple Myeloma (NDMM). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: Local Institution - 102, Scottsdale, Arizona +88 locations
Local Institution - 102, Scottsdale, Arizona
Local Institution - 107, Little Rock, Arkansas
Local Institution - 101, Atlanta, Georgia
Local Institution - 120, Chicago, Illinois
Local Institution - 113, Fairway, Kansas
Local Institution - 106, Baltimore, Maryland
Local Institution - 114, Boston, Massachusetts
Local Institution - 115, Boston, Massachusetts
Local Institution - 110, Boston, Massachusetts
Local Institution - 104, Ann Arbor, Michigan
Local Institution - 103, Detroit, Michigan
Local Institution - 140, Grand Island, Nebraska
Local Institution - 141, Grand Island, Nebraska
Local Institution - 137, Omaha, Nebraska
Local Institution - 138, Omaha, Nebraska
Local Institution - 131, Omaha, Nebraska
Local Institution - 139, Papillion, Nebraska
Local Institution - 756, Cherry Hill, New Jersey
Local Institution - 108, Hackensack, New Jersey
Local Institution - 122, Mineola, New York
Local Institution - 121, New York, New York
Local Institution - 109, New York, New York
Local Institution - 111, New York, New York
Local Institution - 125, Rochester, New York
Local Institution - 112, Charlotte, North Carolina
Local Institution - 117, Cleveland, Ohio
Local Institution - 124, Columbus, Ohio
Local Institution - 116, Philadelphia, Pennsylvania
Local Institution - 123, Greenville, South Carolina
Local Institution - 134, Memphis, Tennessee
Local Institution - 118, Dallas, Texas
Local Institution - 119, Salt Lake City, Utah
Local Institution - 126, Seattle, Washington
Local Institution - 132, Tacoma, Washington
Local Institution - 854, Adelaide, South Australia
Local Institution - 852, Box Hill, Victoria
Local Institution - 904, Calgary, Alberta
Local Institution - 901, Vancouver, British Columbia
Local Institution - 902, Halifax, Nova Scotia
Local Institution - 903, Montreal, Quebec
Local Institution - 704, Lile Cedax, Not set
Local Institution - 701, Pessac, Not set
Local Institution - 703, Pierre Benite cedex, Not set
Local Institution - 702, Poitiers Cedex, Not set
Local Institution - 605, Dresden, Not set
Local Institution - 603, Dusseldorf, Not set
Local Institution - 604, Hamburg, Not set
Local Institution - 602, Heidelberg, Not set
Local Institution - 601, Tuebingen, Not set
Local Institution - 606, Wuerzburg, Not set
Local Institution - 751, Jerusalem, Yerushalayim
Local Institution - 754, Tel Hashomer, Not set
Local Institution - 755, Tel-Aviv, Not set
Local Institution - 307, Meldola, Not set
Local Institution - 305, Pavia, Not set
Local Institution - 302, Reggio Emilia, Not set
Local Institution - 303, Rome, Not set
Local Institution - 301, Torino, Not set
Local Institution - 808, Matsuyama, Ehime
Local Institution - 805, Aomori, Not set
Local Institution - 813, Hiroshima City, Not set
Local Institution - 812, Isehara City, Kanagawa, Not set
Local Institution - 809, Kamogawa, Not set
Local Institution - 802, Kyoto-city, Not set
Local Institution - 811, Nagasaki-shi, Not set
Local Institution - 810, Nagoya, Not set
Local Institution - 801, Nagoya, Not set
Local Institution - 815, Ogaki, Not set
Local Institution - 804, Osaka, Not set
Local Institution - 803, Sendai, Not set
Local Institution - 806, Shinagawa-ku, Tokyo, Not set
Local Institution - 814, Sunto-gun, Not set
Local Institution - 807, Toyohashi, Not set
Local Institution - 503, Amsterdam, NH
Local Institution - 504, Maastrich, Not set
Local Institution - 501, Rotterdam, Not set
Local Institution - 502, Utrecht, Not set
Local Institution - 404, Badalona (Barcelona), Not set
Local Institution - 401, Barcelona, Not set
Local Institution - 405, Barcelona, Not set
Local Institution - 408, Madrid, Not set
Local Institution - 407, Madrid, Not set
Local Institution - 402, Pamplona, Not set
Local Institution - 406, Valencia, Not set
Local Institution - 205, Birmingham, Not set
Local Institution - 202, Leeds, Not set
Local Institution - 204, Oxford, Not set
Local Institution - 201, Sutton, Not set
Local Institution - 203, Sutton, Not set
Conditions: Multiple Myeloma
Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE)
Completed
When the brain detects a drop in oxygen levels in the blood (hypoxia) there is a compensatory increase in blood flow. Acute mountain sickness (AMS) is a cluster of symptoms which commonly occur in those ascending to high altitude and experiencing hypoxia due to increased blood flow and then swelling in the brain. Symptoms include headache, nausea, insomnia and fatigue. The exact mechanisms by which AMS develops remains poorly understood. Dexamethasone has been shown to reduce the risk of develop... Read More
When the brain detects a drop in oxygen levels in the blood (hypoxia) there is a compensatory increase in blood flow. Acute mountain sickness (AMS) is a cluster of symptoms which commonly occur in those ascending to high altitude and experiencing hypoxia due to increased blood flow and then swelling in the brain. Symptoms include headache, nausea, insomnia and fatigue. The exact mechanisms by which AMS develops remains poorly understood. Dexamethasone has been shown to reduce the risk of developing significant brain swelling in other settings. Therefore we hypothesise that administering low dose Dexamethasone could protect against hypoxia induced cerebral and spinal oedema. Read Less
Gender:
ALL
Ages:
Between 20 years and 50 years
Trial Updated:
06/17/2024
Locations: University Hospitals Coventry and Warwickshire NHS Trust, Coventry, West Midlands
University Hospitals Coventry and Warwickshire NHS Trust, Coventry, West Midlands
Conditions: High Altitude Cerebral Edema
A Study to Evaluate Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Withdrawn
The purpose of this study is to evaluate the efficacy and safety of alnuctamab compared to standard of care regimens in participants with relapsed or refractory multiple myeloma (RRMM).
The purpose of this study is to evaluate the efficacy and safety of alnuctamab compared to standard of care regimens in participants with relapsed or refractory multiple myeloma (RRMM). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2024
Locations: Local Institution - 0151, Birmingham, Alabama +169 locations
Local Institution - 0151, Birmingham, Alabama
Local Institution - 0088, Los Angeles, California
Local Institution - 0358, Stanford, California
Local Institution - 0355, New Haven, Connecticut
Local Institution - 0434, Washington, District of Columbia
Local Institution - 0433, Wichita, Kansas
Local Institution - 0439, Saint Matthews, Kentucky
Local Institution - 0323, New Orleans, Louisiana
Local Institution - 0324, Baltimore, Maryland
Local Institution - 0441, Bethesda, Maryland
Local Institution - 0435, Billings, Montana
Local Institution - 0157, Hackensack, New Jersey
Local Institution - 0359, Summit, New Jersey
Local Institution - 0430, Lake Success, New York
Local Institution - 0396, New York, New York
Local Institution - 0306, Cincinnati, Ohio
Local Institution - 0199, Cleveland, Ohio
Local Institution - 0437, Pittsburgh, Pennsylvania
Local Institution - 0352, Providence, Rhode Island
Local Institution - 0420, Watertown, South Dakota
Local Institution - 0168, Dallas, Texas
Local Institution - 0405, Seattle, Washington
Local Institution - 0222, Florencio Varela, Buenos Aires
Local Institution - 0001, La Plata, Buenos Aires
Local Institution - 0262, Pilar, Buenos Aires
Local Institution - 0002, Buenos Aires, Ciudad Autónoma De Buenos Aires
Local Institution - 0260, Liverpool, New South Wales
Local Institution - 0246, Macquarie University, New South Wales
Local Institution - 0022, Waratah, New South Wales
Local Institution - 0397, Brisbane, Queensland
Local Institution - 0021, Box Hill, Victoria
Local Institution - 0019, Clayton, Victoria
Local Institution - 0018, Melbourne, Victoria
Local Institution - 0003, Melbourne, Victoria
Local Institution - 0333, St. Polten, Niederösterreich
Local Institution - 0337, Innsbruck, Tirol
Local Institution - 0334, Salzburg, Not set
Local Institution - 0332, Wien, Not set
Local Institution - 0284, Brasschaat, Antwerpen
Local Institution - 0280, Verviers, Liège
Local Institution - 0279, Yvoir, Namur
Local Institution - 0286, Leuven, Vlaams-Brabant
Local Institution - 0274, Belo Horizonte, Minas Gerais
Local Institution - 0351, Natal, Rio Grande Do Norte
Local Institution - 0369, Sao Paulo, São Paulo
Local Institution - 0291, Rio de Janeiro, Not set
Local Institution - 0211, São Paulo, Not set
Local Institution - 0417, Calgary, Alberta
Local Institution - 0423, Edmonton, Alberta
Local Institution - 0402, London, Ontario
Local Institution - 0395, Toronto, Ontario
Local Institution - 0031, Montreal, Quebec
Local Institution - 0098, Montréal, Quebec
Local Institution - 0027, Santiago, Metropolitana DE Santiago
Local Institution - 0030, Santiago, Región Metropolitana De Santiago
Local Institution - 0026, Santiago, Región Metropolitana De Santiago
Local Institution - 0029, Santiago, Región Metropolitana De Santiago
Local Institution - 0413, Beijing, Beijing
Local Institution - 0230, Beijing, Beijing
Local Institution - 0040, Beijing, Beijing
Local Institution - 0366, Changping, Beijing
Local Institution - 0057, Chongqing, Chongqing
Local Institution - 0066, Guangzhou, Guangdong
Local Institution - 0080, Guangzhou, Guangdong
Local Institution - 0226, Guangzhou, Guangdong
Local Institution - 0368, Shenzhen, Guangdong
Local Institution - 0365, Baoding, Hebei
Local Institution - 0082, Shijiazhuang, Hebei
Local Institution - 0041, Zhengzhou, Henan
Local Institution - 0075, Wuhan, Hubei
Local Institution - 0062, Changsha, Hunan
Local Institution - 0053, Changsha, Hunan
Local Institution - 0055, Nanjing, Jiangsu
Local Institution - 0067, Suzhou, Jiangsu
Local Institution - 0377, Xuzhou, Jiangsu
Local Institution - 0044, Shenyang, Liaoning
Local Institution - 0072, Xi'An, Shaanxi
Local Institution - 0077, Jinan, Shandong
Local Institution - 0083, Jinan, Shandong
Local Institution - 0273, Shanghai, Shanghai
Local Institution - 0421, Shanghai, Shanghai
Local Institution - 0245, Taiyuan, Shanxi
Local Institution - 0056, Tianjin, Tianjin
Local Institution - 0422, Tianjin, Tianjin
Local Institution - 0070, Hangzhou, Zhejiang
Local Institution - 0203, Hangzhou, Zhejiang
Local Institution - 0367, Qingdao, Not set
Local Institution - 0013, Brno, Brno-město
Local Institution - 0247, Olomouc, Olomoucký Kraj
Local Institution - 0012, Praha 2, Not set
Local Institution - 0118, Toulouse, Haute-Garonne
Local Institution - 0225, Montpellier, Languedoc-Roussillon
Local Institution - 0224, Vandoeuvre lès Nancy, Lorraine
Local Institution - 0084, Lille, Nord
Local Institution - 0085, Nantes, Pays-de-la-Loire
Local Institution - 0192, Pierre-Bénite, Rhône
Local Institution - 0331, Heidelberg, Baden-Württemberg
Local Institution - 0330, Tübingen, Baden-Württemberg
Local Institution - 0335, Dresden, Sachsen
Local Institution - 0329, Leipzig, Sachsen
Local Institution - 0339, Hamburg, Not set
Local Institution - 0004, Athens, Attikí
Local Institution - 0136, Chaidari, Attikí
Local Institution - 0103, Nyiregyhaza, Szabolcs-Szatmár-Bereg
Local Institution - 0108, Szombathely, Vas
Local Institution - 0104, Budapest, Not set
Local Institution - 0105, Budapest, Not set
Local Institution - 0370, Visakhapatnam, Andhra Pradesh
Local Institution - 0362, Gurugram, Haryana
Local Institution - 0403, Bangalore, Karnataka
Local Institution - 0399, Lucknow, Uttar Pradesh
Local Institution - 0398, Kolkata, West Bengal
Local Institution - 0281, Cork, Not set
Local Institution - 0371, Dublin, Not set
Local Institution - 0285, Dublin, Not set
Local Institution - 0269, Limerick, Not set
Local Institution - 0096, Meldola, Emilia-Romagna
Local Institution - 0294, Legnano, Milano
Local Institution - 0265, Milan, Milano
Local Institution - 0410, Palermo, Sicilia
Local Institution - 0409, Anjo, Aichi
Local Institution - 0387, Nagoya, Aichi
Local Institution - 0407, Kamogawa, Chiba
Local Institution - 0385, Kashiwa, Chiba
Local Institution - 0386, Isehara, Kanagawa
Local Institution - 0390, Osaka-sayama, Osaka
Local Institution - 0381, Shimotsuga, Tochigi
Local Institution - 0382, Koto, Tokyo
Local Institution - 0419, Aomori, Not set
Local Institution - 0383, Chiba, Not set
Local Institution - 0391, Kumamoto, Not set
Local Institution - 0389, Kyoto, Not set
Local Institution - 0388, Okayama, Not set
Local Institution - 0384, Tokyo, Not set
Local Institution - 0240, Seongnam, Kyǒnggi-do
Local Institution - 0221, Busan, Pusan-Kwangyǒkshi
Local Institution - 0036, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0239, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0034, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0035, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0137, Løenskog, Akershus
Local Institution - 0115, Bergen, Hordaland
Local Institution - 0193, Oslo, Not set
Local Institution - 0242, Lisbon, Lisboa
Local Institution - 0415, Lisbon, Lisboa
Local Institution - 0255, Lisboa, Not set
Local Institution - 0169, Bucuresti, București
Local Institution - 0171, Brasov, Not set
Local Institution - 0414, București, Not set
Local Institution - 0011, Badalona, Barcelona [Barcelona]
Local Institution - 0234, El Palmar, Murcia, Murcia, Región De
Local Institution - 0008, Pamplona, Navarra
Local Institution - 0202, Jerez de la Frontera, Not set
Local Institution - 0006, Salamanca, Not set
Local Institution - 0007, Santiago de Compostela, Not set
Local Institution - 0009, València, Not set
Local Institution - 0114, Borås, Västra Götalands Län [se-14]
Local Institution - 0111, Gothenburg, Västra Götalands Län [se-14]
Local Institution - 0336, Bern, Berne
Local Institution - 0411, st.Gallen, Sankt Gallen
Local Institution - 0338, Zürich, Not set
Local Institution - 0325, Stanbul, İstanbul
Local Institution - 0375, Ankara, Not set
Local Institution - 0188, İzmir, Not set
Local Institution - 0187, Kayseri, Not set
Local Institution - 0349, Southampton, Hampshire
Local Institution - 0342, London, London, City Of
Local Institution - 0350, Cardiff, Not set
Local Institution - 0344, Derby, Not set
Local Institution - 0343, Manchester, Not set
Conditions: Multiple Myeloma
A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.
Completed
This open-label, entry-into-human (EIH) study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of RO7283420. Escalating doses of RO7283420 will be administered to participants with Acute Myeloid Leukemia (AML) in order to determine the maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D).
This open-label, entry-into-human (EIH) study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of RO7283420. Escalating doses of RO7283420 will be administered to participants with Acute Myeloid Leukemia (AML) in order to determine the maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2024
Locations: UC Davis Comprehensive Cancer Center, Sacramento, California +22 locations
UC Davis Comprehensive Cancer Center, Sacramento, California
The University of Texas MD Anderson Cancer Center, Houston, Texas
Peter MacCallum Cancer Centre; Medical Oncology, Melbourne, Victoria
The Alfred, Melbourne, Victoria
Princess Margaret Cancer Center, Toronto, Ontario
Rigshospitalet; Hæmatologisk Klinik, Klinisk Afprøvnings Team KAT, København Ø, Not set
Institut Paoli Calmettes; Departement D' Onco-Hematologie, Marseille, Not set
Hopital De Haut Leveque; Hematologie Clinique, Pessac, Not set
Uniklinikum "Carl Gustav Carus"; Med. Klinik 1; Hämatologie, Zelltherapie und Medizinische Onkologie, Dresden, Not set
Klinikum der Universität München, Campus Großhadern; Medizinische Klinik und Poliklinik III, München, Not set
ASST PAPA GIOVANNI XXIII; Ematologia, Bergamo, Lombardia
Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia, Rozzano, Lombardia
Ospedale Santa Chiara; Unita Operativa Di Ematologia, Pisa, Toscana
Institut Catala d?Oncologia Hospital Germans Trias i Pujol, Badalona, Barcelona
Hospital Universitari Vall d'Hebron; Servicio de Hematologia, Barcelona, Not set
Hospital Clínic i Provincial; Servicio de Hematología y Oncología, Barcelona, Not set
Hospital Univ. 12 de Octubre; Servicio de Hematologia, Madrid, Not set
Hospital Universitario la Fe; Servicio de Hematologia, Valencia, Not set
China Medical University Hospital; Oncology and Hematology, Taichung, Not set
National Cheng Kung University Hospital; Oncology, Tainan, Not set
National Taiwan Universtiy Hospital; Division of Hematology, Taipei, Not set
Churchill Hospital, Oxford, Not set
Royal Marsden NHS Foundation Trust, Sutton, Not set
Conditions: Acute Myeloid Leukemia
Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL)
Completed
B-precursor ALL is an aggressive malignant disease. Therapy is usually stratified according to risk characteristics to ensure that appropriate treatment is administered to patients with high-risk of relapse. In general, pediatric treatment regimens are more intense than those employed in adults and include courses of combination chemotherapy. Standard of care chemotherapy is associated with considerable toxicity. There is a lack of novel treatment options for subjects who relapse or are refracto... Read More
B-precursor ALL is an aggressive malignant disease. Therapy is usually stratified according to risk characteristics to ensure that appropriate treatment is administered to patients with high-risk of relapse. In general, pediatric treatment regimens are more intense than those employed in adults and include courses of combination chemotherapy. Standard of care chemotherapy is associated with considerable toxicity. There is a lack of novel treatment options for subjects who relapse or are refractory to treatment. Therefore, innovative therapeutic approaches are urgently needed. Blinatumomab is a bispecific single-chain antibody construct designed to link B cells and T cells resulting in T cell activation and a cytotoxic T cell response against CD19 expressing cells. This study will evaluate the event-free survival (EFS) after treatment with blinatumomab when compared to standard of care (SOC) chemotherapy. The effect of blinatumomab on overall survival and reduction of minimal residual disease compared to SOC chemotherapy will also be investigated. Read Less
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
05/10/2024
Locations: Research Site, Ciudad Autonoma de Buenos Aires, Buenos Aires +102 locations
Research Site, Ciudad Autonoma de Buenos Aires, Buenos Aires
Research Site, Randwick, New South Wales
Research Site, Westmead, New South Wales
Research Site, South Brisbane, Queensland
Research Site, Parkville, Victoria
Research Site, Graz, Not set
Research Site, Innsbruck, Not set
Research Site, Wien, Not set
Research Site, Brussels, Not set
Research Site, Brussels, Not set
Research Site, Gent, Not set
Research Site, Leuven, Not set
Research Site, Liege, Not set
Research Site, Curitba, Paraná
Research Site, Porto Alegre, Rio Grande Do Sul
Research Site, Sao Paulo, São Paulo
Research Site, Sao Paulo, São Paulo
Research Site, Praha 5, Not set
Research Site, Kobenhavn O, Not set
Research Site, Bordeaux Cedex, Not set
Research Site, Lille, Not set
Research Site, Lyon, Not set
Research Site, Marseille cedex 5, Not set
Research Site, Montpellier cedex 05, Not set
Research Site, Nantes cedex 1, Not set
Research Site, Paris, Not set
Research Site, Paris, Not set
Research Site, Strasbourg Cedex, Not set
Research Site, Vandoeuvre les Nancy, Not set
Research Site, Berlin, Not set
Research Site, Duesseldorf, Not set
Research Site, Erlangen, Not set
Research Site, Essen, Not set
Research Site, Frankfurt am Main, Not set
Research Site, Freiburg, Not set
Research Site, Giessen, Not set
Research Site, Hamburg, Not set
Research Site, Hannover, Not set
Research Site, Jena, Not set
Research Site, Kiel, Not set
Research Site, München, Not set
Research Site, Münster, Not set
Research Site, Tübingen, Not set
Research Site, Ulm, Not set
Research Site, Würzburg, Not set
Research Site, Goudi, Not set
Research Site, Haifa, Not set
Research Site, Jerusalem, Not set
Research Site, Petah Tikva, Not set
Research Site, Tel Aviv, Not set
Research Site, Tel Hashomer, Not set
Research Site, Bologna, Not set
Research Site, Genova, Not set
Research Site, Monza (MB), Not set
Research Site, Napoli, Not set
Research Site, Padova, Not set
Research Site, Pavia, Not set
Research Site, Roma, Not set
Research Site, Roma, Not set
Research Site, Torino, Not set
Research Site, Mexico, Distrito Federal
Research Site, Guadalajara, Jalisco
Research Site, Monterrey, Nuevo León
Research Site, Rotterdam, Not set
Research Site, Utrecht, Not set
Research Site, Oslo, Not set
Research Site, Bydgoszcz, Not set
Research Site, Krakow, Not set
Research Site, Lublin, Not set
Research Site, Wroclaw, Not set
Research Site, Zabrze, Not set
Research Site, Lisboa, Not set
Research Site, Porto, Not set
Research Site, Bucharest, Not set
Research Site, Cluj-Napoca, Not set
Research Site, Moscow, Not set
Research Site, Saint Petersburg, Not set
Research Site, Malaga, Andalucía
Research Site, Sevilla, Andalucía
Research Site, Santander, Cantabria
Research Site, Barcelona, Cataluña
Research Site, Barcelona, Cataluña
Research Site, Valencia, Comunidad Valenciana
Research Site, Santiago de Compostela, Galicia
Research Site, Boadilla del Monte, Madrid
Research Site, El Palmar, Murcia
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Stockholm, Not set
Research Site, Basel, Not set
Research Site, Zuerich, Not set
Research Site, Adana, Not set
Research Site, Antalya, Not set
Research Site, Izmir, Not set
Research Site, Kayseri, Not set
Research Site, Birmingham, Not set
Research Site, Bristol, Not set
Research Site, Glasgow, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Newcastle upon Tyne, Not set
Research Site, Sheffield, Not set
Research Site, Sutton, Not set
Conditions: Leukemia, Acute Lymphoblastic
MUK Nine b: OPTIMUM Treatment Protocol
Active Not Recruiting
To determine whether a combination of four novel agents bortezomib(Velcade), lenalidomide (Revlimid), Daratumumab (Darzalex) \& dexamethasone in combination with low-dose cyclophosphamide is sufficiently active in a high risk population of myeloma patients, to take forward into a phase III trial compared to standard treatment.
To determine whether a combination of four novel agents bortezomib(Velcade), lenalidomide (Revlimid), Daratumumab (Darzalex) \& dexamethasone in combination with low-dose cyclophosphamide is sufficiently active in a high risk population of myeloma patients, to take forward into a phase III trial compared to standard treatment. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/10/2024
Locations: Queen Elizabeth Hospital, Birmingham, Not set +20 locations
Queen Elizabeth Hospital, Birmingham, Not set
Birmingham Heartlands Hospital, Birmingham, Not set
Blackpool Victoria Hospital, Blackpool, Not set
Royal Hampshire County Hospital, Bournemouth, Not set
Royal Bournemouth Hospital, Bournemouth, Not set
Bristol Haematology & Oncology Centre, Bristol, Not set
Ninewells Hospital, Dundee, Not set
Beatson Oncology Centre, Glasgow, Not set
Kettering General Hosptial, Kettering, Not set
Leicester Royal Infirmary, Leicester, Not set
Kings College Hosptial, London, Not set
Manchester Royal Infirmary, Manchester, Not set
The Christie Hospital, Manchester, Not set
Norfolk and Norwich University Hospital, Norwich, Not set
Nottingham University Hosptial, Nottingham, Not set
Churchill Hospital, Oxford, Not set
Derriford Hospital, Plymouth, Not set
Southampton General Hospital, Southampton, Not set
Royal Stoke Hospital, Stoke-on-Trent, Not set
Royal Marsden Hospital, Sutton, Not set
Worcester Royal Hospital, Worcester, Not set
Conditions: Multiple Myeloma
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