Pilot Study of a Sedentary Behaviour Intervention for Individuals With a Spinal Cord Injury
NCT06957483
Recruiting
Individuals with spinal cord injury have a greater risk of heart disease and stroke than non-disabled individuals. This might be partly because wheelchair users engage in high amounts of sedentary behaviour. A review found a lack of programmes aimed at reducing sedentary behaviour in individuals with paraplegia. This means we do not know how good these programmes are for reducing heart disease risk markers. A programme to support reductions in sedentary behaviour has been co-designed with indiv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: Brunel University of London, Uxbridge, London
Conditions: Spinal Cord Injury
Register for Updates
EEG Monitoring for Refractory Status Epilepticus
NCT04170491
Recruiting
This is a prospective randomized study to investigate the yield of continuous electroencephalogram (cEEG), as a diagnostic tool in intensive care unit (ICU), for patients with refractory status epilepticus (RSE) and the contribution of this test to the patient final outcome, compared with standard medical care. Specifically, the hypothesis is that the use of cEEG for patients with RSE will significantly reduce the length of in-hospital stay, mortality, and subsequent complications (such as infec... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
05/02/2025
Locations: Royal London Hospital, London, Not set
Conditions: Status Epilepticus
Register for Updates
UK Heart Failure With Preserved Ejection Fraction
NCT05441839
Recruiting
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the seve... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/01/2025
Locations: Cwm Taf Morgannwg University Health Board, Abercynon, Not set +25 locations
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF)
Register for Updates
Study of Subretinally Injected AAVB-081 in Patients With Usher Syndrome Type IB (USH1B) Retinitis Pigmentosa
NCT06591793
Recruiting
The purpose of the 081-101 study is to evaluate the safety and tolerability of a single subretinal injection of AAVB-081 in USH1B patients with retinitis pigmentosa due to a mutation in the MYO7A gene. The study will also assess the initial efficacy following AAVB-081 administration.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
05/01/2025
Locations: University of Campania Luigi Vanvitelli, Naples, Not set +2 locations
Conditions: Usher Syndrome, Type 1B
Register for Updates
Lutathera and ASTX727 in Neuroendocrine Tumours
NCT05178693
Recruiting
Patients entered into the study will receive ASTX727 orally for 5 days, prior to receiving Lutathera treatment on Day 8, to determine whether pre-treatment with ASTX727 results in re-expression of somatostatin receptor-2 in patients with metastatic neuroendocrine tumours. The study will use \[68Ga\]-DOTA-TATE PET to image epigenetic modification of the receptor locus.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/01/2025
Locations: Hammersmith Hospital, London, London, City of
Conditions: Neuroendocrine Tumors
Register for Updates
Trial of THEO-260 in Ovarian Cancer Patients
NCT06618235
Recruiting
The goal of this clinical trial is to establish if THEO-260 is safe to administer to adult females with ovarian cancer. It will also aim to establish if THEO-260 is able to treat ovarian cancer. The main questions it aims to answer are: * What medical problems do participants have when taking THEO-260? * At what dose is THEO-260 both safe but also shows signs of being able to treat ovarian cancer? * At the selected dose, test THEO-260 is a wider group of participants to confirm the safety and a... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/01/2025
Locations: The Beatson West of Scotland Cancer Centre, Glasgow, Scotland +1 locations
Conditions: Ovarian Cancer
Register for Updates
Increasing the Use of an Anti-snoring Mouth Guard (Mandibular Advancement Appliance) to Prevent Upper Airway Collapse During Sleep in Patients With Obstructive Sleep Apnoea.
NCT04092660
Recruiting
Obstructive Sleep Apnoea (OSA) is a sleep-related breathing disorder that is characterized by the repeated collapse of the upper airway during sleep, resulting in sleep deprivation. Mandibular Advancement Appliances (MAA) or Oral Appliances (OA) is prescribed for the patients with OSA and they have been shown to be effective. However, they rely entirely on the patient's acceptance and use. The aim of this study is to assess whether interventions- additional support approaches, will help patients... Read More
Gender:
ALL
Ages:
Between 40 years and 90 years
Trial Updated:
05/01/2025
Locations: Royal London Dental Hospital, London, Not set
Conditions: Obstructive Sleep Apnea
Register for Updates
PRIMER: Development of Daily Online Magnetic Resonance Imaging for Magnetic Resonance Image Guided Radiotherapy
NCT02973828
Recruiting
In radiotherapy high-tech scans with x-rays (CT scans) are taken before and during treatment to locate the tumour and ensure the radiation is hitting the target. These x-rays expose patients to additional radiation and the quality of these scans is often poor which makes it difficult to distinguish tumour from normal tissue and there may be uncertainty in the tumour position due to movement or shrinkage. To allow for these uncertainties a large margin around the tumour is also treated, but this... Read More
Gender:
ALL
Ages:
3 years and above
Trial Updated:
05/01/2025
Locations: The Royal Marsden NHS Foundation Trust, Sutton, Surrey
Conditions: Adenocarcinoma
Register for Updates
naVIGation Invitations Liver surveillANce upTake
NCT06635694
Recruiting
This study aims to evaluate the efficacy of Patient Navigators and mailed surveillance invitations on attendance of Hepatocellular Carcinoma (HCC) ultrasound surveillance appointments. The investigators hypothesise that mailed invitations and Patient Navigators will improve attendance at HCC surveillance appointments and increase the proportion of patients diagnosed at an early stage, compared with a control group receiving usual care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/01/2025
Locations: Imperial College Healthcare NHS Trust, London, Not set
Conditions: Hepatocellular Carcinoma, Liver Cirrhosis, Chronic Hep B
Register for Updates
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
NCT06233461
Recruiting
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately to severely active Crohn's disease (CD). The main aim of this study is to learn if the 3 different doses of TAK-279 reduce bowel inflammation and ulcers in the bowel compared to the placebo after 12 weeks of treatment. Another aim is to compare any medical problems that... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/30/2025
Locations: GastroIntestinal BioSciences, Los Angeles, California +196 locations
Conditions: Crohn's Disease
Register for Updates
KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer
NCT03946202
Recruiting
This is a study aimed at testing a commonly available and inexpensive chemical (hydrogen peroxide) for efficacy in sensitising large cancerous lumps in the breast to a standard course of radiotherapy in patients with locally advanced or recurrent breast cancer. Laboratory research and initial clinical trials in Japan suggest that 4 to 6 injections of a radiation sensitiser ('KORTUC') based on very dilute (0.5%) hydrogen peroxide injected into cancers under local anaesthetic twice a week during r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Regional Cancer Centre (RCC), Trivandrum, Kerala +8 locations
Conditions: Breast Cancer
Register for Updates
PASS to Assess Cardiovascular and Cerebrovascular Events in COPD Patients Initiating Fixed Triple Therapy (DPI or pMDI)
NCT05652439
Recruiting
The aim of this Post Authorisation Safety Study (PASS) is to assess the incidence of adverse cardiovascular and cerebrovascular events in COPD patients who are new to inhaled fixed triple therapy (dual bronchodilator plus corticosteroid) administered via Dry Powder Inhaler (DPI) compared to new users of pressurized Metered Dose Inhaler (pMDI). Data from clinical practice from different European data sources will be collected. The baseline hypothesis is that the DPI is not associated with differ... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
04/30/2025
Locations: Clinical Practice Research Datalink (CPRD), London, Not set
Conditions: Chronic Obstructive Pulmonary Disease
Register for Updates