Investigating the Metabolic and Lipidomic Profiles That Are Associated With Varying Grades of Diabetic Maculopathy and Retinopathy in South Wales
NCT06914778
Recruiting
Diabetes mellitus is a disorder of sugar and fat metabolism which results in damage to the small blood vessels in various organs, this includes the retina - the part of the eye that processes light into a nerve impulse. This leads to damage and blindness via various different mechanisms that are not fully understood. In this study the objective is to recruit people with diabetes and various stages of diabetic eye disease and measure a large number of different chemicals within the blood that mi... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/08/2025
Locations: Prince Philip Hospital, Llanelli, Wales
Conditions: Diabetic Retinopathy (DR), Diabetic Retinopathy Associated With Type 2 Diabetes Mellitus, Diabetic Macular Edema (DME)
Register for Updates
Chemotherapy Induced Cognitive Impairment
NCT05740787
Recruiting
Chemotherapy is toxic and challenges everyone differently. Most chemotherapy side-effects are known and well documented. However, the phenomenon of "chemo fog" also known as "chemobrain" has not been fully investigated and is often based on comments of breast cancer patients attending outpatient clinics during and after their chemotherapy. Changes in thinking ability like lack of concentration, loss of memory and the inability to hold a thought or even a conversation has a significant impact on... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: NHS Grampian, Aberdeen, Not set
Conditions: Breast Cancer
Register for Updates
Attitudes to Gynae Oncology Care Location - GRACEFUL
NCT06920342
Recruiting
Gynaecological oncology (cancer) place of care is often based on evolution of services, along historical professional boundaries, rather than user needs or preferences. The investigators aim to gather views of patients in the United Kingdom (UK) on their preferred place of care for investigation, treatment and follow-up of gynaecological cancer. An initial scoping review found no previous work in this area. Pilot work, performed to inform local re-organisation of services, found that 53% of part... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/07/2025
Locations: Somerset NHS Foundation Trust, Taunton, Somerset
Conditions: Gynecologic Cancers
Register for Updates
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NCT04124120
Recruiting
The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grfating (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grfating (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocar... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California +140 locations
Conditions: Heart Diseases, Coronary Artery Disease, Coronary Artery Bypass Grafting
Register for Updates
Study of WAL0921 in Patients With Glomerular Kidney Diseases
NCT06466135
Recruiting
This is an adaptive prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of WAL0921 in subjects with glomerular kidney disease and proteinuria, including diabetic nephropathy and rare glomerular kidney diseases (primary focal segmental glomerulosclerosis \[FSGS\], treatment-resistant minimal change disease \[TR MCD\], primary immunoglobulin A nephropathy \[IgAN\], and primary membranous nephropathy... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/04/2025
Locations: Colorado Kidney and Vascular Care, Denver, Colorado +8 locations
Conditions: Diabetic Nephropathies, Primary Focal Segmental Glomerulosclerosis, Minimal Change Disease, Primary Immunoglobulin A Nephropathy, Primary Membranous Nephropathy
Register for Updates
Enteral Feeding of Fibre to Improve Microbiota
NCT06288464
Recruiting
Following surgical removal of diseased bowel, patients often require a temporary redirection of bowel contents to a stoma, to allow healing prior to re-joining of the remaining bowel at a later date. Some patients may experience complications, either during or after reversal surgery, and this may be due to changes in the 'friendly' bacteria that live in our bowels. Previous research shows that the distal section of bowel that is non-functioning undergoes tissue-wasting and the 'friendly' bacteri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2025
Locations: Lancashire Teaching Hospitals NHS, Preston, Lancashire
Conditions: Bowel Dysfunction, Colon Disease, Ileum--Diseases
Register for Updates
Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery
NCT06800430
Recruiting
Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the heart. Unfortunately, these grafts can sometimes fail, and patients can also experience complications like heart attacks and strokes, after surgery. It is known that vein grafts are more likely to narrow over time. Additionally, treating vein graft failure is very challen... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Royal Infirmary of Edinburgh, Edinburgh, Midlothian
Conditions: Coronary Artery Bypass, Graft Failure, Coronary Artery Bypass Graft, Coronary Artery Bypass Graft Surgery (CABG)
Register for Updates
The Biomechanical Outcomes of Autologous Chondrocyte Implantation
NCT06921889
Recruiting
Injury to the knee can damage the lining of the knee's bones, called cartilage. Cartilage injuries cause pain and limit movement, making activities like walking, playing sports, and working difficult. Cartilage cannot repair itself well, so surgery is often needed to repair it. People who have cartilage repair surgery want to return to normal activities after their operation. Doctors and scientists know the operation can reduce pain, but do not fully understand how it affects movement. This re... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Royal Orthopaedic Hospital, Birmingham, Not set +6 locations
Conditions: Chondral Defect
Register for Updates
Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML
NCT06652438
Recruiting
Treatment of patients with newly diagnosed AML who are not eligible for intensive chemotherapy has remained an area of high unmet medical need. The combination therapy with two medicines, azacitidine and venetoclax, is the usual plan of action. This has brought significant progress in the treatment, but it nevertheless is not curative and the disease does relapse over time. Revumenib blocks a specific molecule called menin in the cell nucleus. Some types of AML are reliant on menin working prop... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: DE-Berlin-CAMPUSBENFRANKLIN, Berlin, Not set +66 locations
Conditions: Acute Myeloid Leukemia, Adult
Register for Updates
Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation
NCT04788888
Recruiting
Evaluation of TAVR using the NAVITOR valve in a Global Investigation.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/03/2025
Locations: St. Andrew's Hospital, Adelaide, Not set +38 locations
Conditions: Symptomatic Severe Aortic Stenosis
Register for Updates
GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)
NCT05818150
Recruiting
This multicenter, prospective, interventional trial is designed to assess the outcome of subjects with symptomatic knee osteoarthritis (OA) that are randomized to treatment with either genicular artery embolization (GAE) using Embosphere Microspheres or steroid injection over a period of 24 months.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/03/2025
Locations: Georgetown University Medical Center, Washington, D.C., District of Columbia +22 locations
Conditions: Knee Osteoarthritis
Register for Updates
Triple Assay of Rectal Mucus in the Diagnosis of Colorectal Cancer
NCT06649123
Recruiting
Development of a multiomics assay for use on OriColTM sampled rectal mucus for detection of cancer and significant polyps in symptomatic patients on the Colorectal Urgent Suspected Cancer pathway.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/02/2025
Locations: Shrewsbury & Telford NHS Foundation Trust, Telford, Shropshire
Conditions: Colorectal Cancer, Adenoma Colon Polyp
Register for Updates