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All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1489 - 1500 of 3097
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Clinical Trial Phase
European TauroPace Registry - University of Schleswig-Holstein Prospective Observational Clinical Study
Recruiting
University of Schleswig-Holstein Campus Kiel is sponsoring the European TauroPace Registry. This investigator-initiated local, prospective, non-interventional, multi-center study includes patients undergoing cardiac implantable electronic placement including and not limited to placement, revision with the aim to upgrade or downgrade, generator substitution, additional lead placement, revision or extraction (procedure) with adjunct TauroPace. It is planned to include a total of at least 2300 proc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Landeskrankenhaus Wiener Neustadt, Wiener Neustadt, Not set +7 locations
Conditions: CIED Related Infection
Assessment of GORE® SYNECOR Biomaterial in Focused Patient Populations and Long-Term Application
Recruiting
The SYN 20-01 Study is a non-interventional, prospective, multicenter, multicohort, international, post-market clinical investigation looking into the assessment of GORE® SYNECOR Biomaterial in focused patient populations and in long-term application.
Patients with ventral / incisional hernia amenable to hernia mesh repair will be enrolled into two cohorts (US and EU cohort) and followed-up over the period of 60 months.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/02/2025
Locations: Emory Saint Joseph's Hospital, Atlanta, Georgia +14 locations
Conditions: Hernia, Ventral, Hernia Incisional, Hernia Incisional Ventral
Assessing Cancer Treatment Response to Therapy Using 18F-FSPG PET
Recruiting
Prospective single centre non-randomised exploratory observational study to measure changes in tumour cellular redox status with 18F-FSPG PET in stage 3 non-small cell lung cancer (NSCLC) and stage 3 and 4 head and neck squamous cell cancer (HNSCC) at baseline and during standard of care treatment, and to compare this with 18F-FDG PET/CT and RECIST 1.1 response at 12 weeks.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
04/02/2025
Locations: Guy's and St Thomas' NHS Foundation Trust, London, Not set
Conditions: Cancer, Diagnosis, Resistant Cancer, Response, Acute Phase
Triple Assay of Rectal Mucus in the Diagnosis of Colorectal Cancer
Recruiting
Development of a multiomics assay for use on OriColTM sampled rectal mucus for detection of cancer and significant polyps in symptomatic patients on the Colorectal Urgent Suspected Cancer pathway.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/02/2025
Locations: Shrewsbury & Telford NHS Foundation Trust, Telford, Shropshire
Conditions: Colorectal Cancer, Adenoma Colon Polyp
Renal Perfusion and the Development of AKI Following Traumatic Injury
Recruiting
Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: King's College Hospital, London, Not set
Conditions: Traumatic Haemorrhagic Shock, AKI (Acute Kidney Injury) Due to Trauma, AKI - Acute Kidney Injury
Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage
Recruiting
Older people falling from a standing height is the most common cause of hospital admission for head injury. Up to 1 in 3 patients admitted are taking a tablet medication which thins the blood, known as an oral anticoagulant. This type of medication can increase the likelihood of bleeding in the brain. Many patients are taking oral anticoagulation due to having an irregular heartbeat (called atrial fibrillation) or because of having a previous stroke or blood clots. When a scan shows blood in the... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/01/2025
Locations: University Hospitals Plymouth NHS Trust, Plymouth, Devon +1 locations
Conditions: Traumatic Intracranial Haemorrhage
A Multicenter Multinational Observational Study of Children With Hypochondroplasia
Recruiting
This study will assess growth over time and the clinical course of HCH in children by collecting growth measurements and other variables of interest.
Gender:
ALL
Ages:
15 years and below
Trial Updated:
04/01/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +42 locations
Conditions: Hypochondroplasia
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
Recruiting
Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal macrovascular organ blood flow. This intra-renal perfusion abnormality may be amenable to pharmacological manipulation, which may offer mechanistic insight into the pathophysiology of septic AKI. The aim of the current study is to investigate the effects of vasopressin and angio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: King's College Hospital, London, Not set
Conditions: Septic Shock, Acute Kidney Injury
WATER IV Prostate Cancer
Recruiting
This is a multicenter, prospective, randomized clinical trial that aims to assess the safety and efficacy of Aquablation Therapy in men with low-risk to intermediate to high-risk localized prostate cancer who are candidates for, or have opted for, prostatectomy. Participants will be randomized to either Aquablation Therapy or radical prostatectomy and followed up to 10 years.
Gender:
MALE
Ages:
45 years and above
Trial Updated:
04/01/2025
Locations: Arizona State Urological Institute, Chandler, Arizona +38 locations
Conditions: Localized Prostate Cancer
The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.
Recruiting
The purpose of this study is to evaluate the potential benefits of 145 mg of daily fenofibrate in adults with type 1 diabetes mellitus and pre-existing non-proliferative diabetic retinopathy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Canberra Hospital, Garran, Australian Capital Territory +23 locations
Conditions: Type 1 Diabetes Mellitus, Diabetic Retinopathy, Diabetic Nephropathies
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
Recruiting
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Royal Adelaide Hospital, Adelaide, Not set +263 locations
Conditions: End-Stage Kidney Disease
SCIB1 and iSCIB1+ in Melanoma Patients Receiving Nivolumab With Ipilimumab or SCIB1 With Pembrolizumab (The SCOPE Study)
Recruiting
The purpose of this study is to find out if two new treatment cancer vaccines called SCIB1 and iSCIB1+ can be used safely when added to nivolumab (Opdivo) with ipilimumab (Yervoy), or SCIB1 with pembrolizumab (Keytruda). Pembrolizumab or nivolumab with ipilimumab are standard treatments approved for patients with advanced melanoma (skin cancer).
The study will also look to see if SCIB1 or iSCIB1+ can increase the likelihood that melanoma patients will respond to the standard treatments, and als... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Cambridge University Hospitals NHS Foundation Trust, Cambridge, Not set +14 locations
Conditions: Malignant Melanoma, Melanoma (Skin), Melanoma Stage III, Melanoma Stage IV
1489 - 1500 of 3097