Biobank Cycle Collection
NCT05642637
Recruiting
This study will provide daily urine samples from volunteers who are trying to conceive in order to maintain the SPD biobank. Study volunteers, seeking to conceive will be provided with a CE marked Clearblue Ovulation product to help them pinpoint their most fertile time and aid conception. All volunteers will provide daily early morning urine samples throughout the study period and keep a study diary of menses and pregnancy test results for up to 3 menstrual cycles. Urine samples will be recei... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: SPD Development Company Ltd, Bedford, Bedfordshire
Conditions: Pregnancy
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A Study on Safety and Effectiveness of Long-term Treatment With Vamorolone in Boys With Duchenne Muscular Dystrophy
NCT06713135
Recruiting
This study aims to assess safety and effectivness of long-term treatment with vamorolone in boys with Duchenne Muscular Dystrophy (DMD) who have completed prior studies with vamorolone.
Gender:
MALE
Ages:
All
Trial Updated:
11/26/2024
Locations: UZ Gent (Universitair Ziekenhuis Gent), Gent, Not set +11 locations
Conditions: Duchenne Muscular Dystrophy
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Observational SIR-Spheres Study for the Treatment of Unresectable Liver Tumors (SIRtain Registry)
NCT05967143
Recruiting
This registry seeks to prospectively gather a large repository of comprehensive observational data reflecting routine use of SIR-Spheres in patients diagnosed with unresectable HCC or unresectable liver metastases from mCRC refractory to or intolerant to chemotherapy, in order to assess clinical response in a real-world setting and further validate the safe and appropriate use of SIR-Spheres
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Hôpital Beaujon, Clichy, Cedex +8 locations
Conditions: Unresectable Hepatocellular Carcinoma (HCC), Liver Metastases From Colorectal Cancer (mCRC)
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E-Detection Tool for Emerging Mental Disorders
NCT05127278
Recruiting
Psychosis is a severe mental disorder that involves abnormal experiences and altered behaviour. Although the onset of psychosis occurs in young people, most cases will only be identified later in the course of illness. The delayed detection is the main cause of significant negative long-term outcomes. The current proposal will develop an innovative E-mental health detection tool to effectively improve the identification of young people with emerging psychosis. This tool will be implemented on d... Read More
Gender:
ALL
Ages:
Between 12 years and 35 years
Trial Updated:
11/26/2024
Locations: Glasgow University, Glasgow, Not set +1 locations
Conditions: Psychosis
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Refining Adjuvant Treatment in Endometrial Cancer Based on Molecular Features
NCT05255653
Recruiting
The RAINBO umbrella program consists of four clinical trials investigating new adjuvant therapies in endometrial cancer patients. Eligible patients will be assigned to one of the four RAINBO trials based on the molecular profile of their cancer: * p53 abnormal endometrial cancer patients to the p53abn-RED trial * mismatch repair deficient endometrial cancer patients to the MMRd-GREEN trial * no specific molecular profile endometrial cancer patients to NSMP-ORANGE trial * POLE mutant endometrial... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: The POLEmut-BLUE trial: Princess Margaret Cancer Centre, University of Toronto, Toronto, Not set +13 locations
Conditions: Endometrial Cancer
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Hybrid AbLaTion of Atrial Fibrillation
NCT05411614
Recruiting
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: St Georges University of London, London, Not set
Conditions: Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent, Atrial Arrhythmia, Atrial Fibrillation
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Thromboprophylaxis in Lower Limb Immobilisation
NCT06370273
Recruiting
The goal of this clinical trial is to find out the clinical and cost effectiveness of Thromboprophylaxis in participants who have been placed in a plaster cast or splint after injury. The main questions it aims to answer are: * whether giving tablets to people at high risks of clots after a leg injury is as good as injections (standard care) * whether giving any medication after a leg injury is better than standard care (advice only) for people at low risk of clots. Participants will be asses... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
11/26/2024
Locations: Epsom and St Helier University Hospitals NHS Trust, Carshalton, Surrey +2 locations
Conditions: Thrombosis, Injury Leg
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ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficiency
NCT06462547
Recruiting
The purpose of this study (Study INZ701-304 \[ADAPT\]) is to assess the long-term safety of INZ-701 in patients with ENPP1 Deficiency or ABCC6 Deficiency who have received INZ-701 in an existing clinical study and choose to continue dosing for the potential treatment of their condition.
Gender:
ALL
Ages:
1 year and above
Trial Updated:
11/26/2024
Locations: Mayo Clinic, Rochester, Minnesota +4 locations
Conditions: Gene Mutations, Pseudoxanthoma Elasticum, Arterial Calcification, Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Autosomal Recessive Hypophosphatemic Rickets Type 2
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Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
NCT03860883
Recruiting
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: University of South Alabama Mitchell Cancer Institute, Mobile, Alabama +191 locations
Conditions: Cutaneous Melanoma, Stage II
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Sweet Thresholds in Healthy Volunteers Study
NCT06697847
Recruiting
The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Westbury Lodge, Westbury Park, Bristol, City Of Bristol
Conditions: Taste Thresholds in Healthy Volunteers
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A Comparison of Two Brief Interventions for People with Chronic Low Back Pain
NCT06218459
Recruiting
The goal is to undertake a Decentralized Randomized Pilot Feasibility study to inform the methods for a definitive Randomized Controlled Trial (RCT) (including recruitment success, participant experience, intervention delivery, safety, outcome measurement and sample size estimation). The main question is if the methods used are feasible for an adequately powered future RCT. Participants will be randomly allocated to receive either: Intervention - OldPain2Go® treatment or Placebo Control - Jacobs... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Norton Physiotherapy Centre, Norton, Stockton-on-Tees
Conditions: Low Back Pain
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Post Splenectomy Infections After Surgery for Peritoneal Malignancies (OPSI)
NCT05718726
Recruiting
The spleen is involved in maintaining immunity and plays an important role in the elimination of encapsulated bacteria and parasites. Patients who undergo splenectomy in conjunction with complete CRS for peritoneal malignancy are at risk of overwhelming post-splenectomy infections post-operatively. These patients are therefore administered vaccinations to lower the risk of infections but as they do not completely eliminate the risk, patients are also prescribed prophylactic antibiotics without c... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
11/25/2024
Locations: The Peritoneal Malignancy Institute, Hampshire Hospitals NHS Foundation Trust, Basingstoke, Hampshire
Conditions: Peritoneal Cancer, Infection;Post Surg Procedure
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