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All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1993 - 2004 of 3097
A Comparison of Two Brief Interventions for People with Chronic Low Back Pain
Recruiting
The goal is to undertake a Decentralized Randomized Pilot Feasibility study to inform the methods for a definitive Randomized Controlled Trial (RCT) (including recruitment success, participant experience, intervention delivery, safety, outcome measurement and sample size estimation). The main question is if the methods used are feasible for an adequately powered future RCT. Participants will be randomly allocated to receive either: Intervention - OldPain2Go® treatment or Placebo Control - Jacobs... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Norton Physiotherapy Centre, Norton, Stockton-on-Tees
Conditions: Low Back Pain
Observation of Clinical Routine Care for Heart Failure Patients Implanted With BIOTRONIK CRT Devices
Recruiting
The registry is primarily designed to assess outcome, efficacy and residual safety aspects of CRT based on long-term data from an unselected, real-life clinical set-up. Moreover, the observation of the patient status should help to find possible predictors for HF events and to identify areas of improvement for CRT and for CRT device settings.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Canberra Heart Rhythm Foundation, Canberra, Not set +120 locations
Conditions: Heart Failure
Prospective Study of White Blood Cells
Recruiting
The purpose of this study is to investigate white blood cells from volunteering donors to support the development of engineered regulatory T cell therapies.
Gender:
ALL
Ages:
All
Trial Updated:
11/22/2024
Locations: Quell Investigator Site 01, London, Not set
Conditions: Autoimmune Diseases, Inflammation, Rejection; Transplant, Liver
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
Recruiting
Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry and recruit patients across academic and community practices from Australia, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, Spain, South Africa, Sweden, Switzerland, the United Kingd... Read More
Gender:
MALE
Ages:
21 years and above
Trial Updated:
11/21/2024
Locations: University of Alabama-Birmingham, Birmingham, Alabama +120 locations
Conditions: Prostate Cancer
Effects of Online Metacognitive Training Group on Distressing Beliefs
Recruiting
Psychosis is characterized by distorted perceptions of reality, often involving persecutory delusions. Research links these symptoms to cognitive biases like "jumping to conclusions." Despite mixed reviews of Cognitive Behavioral Therapy (CBTp) for psychosis, a study will explore metacognitive training (MCT) delivered online. This training will be tested over 10 weeks with participants from a psychosis service in Kent, assessing its effect through interviews and questionnaires before and after t... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/21/2024
Locations: Kent and Medway NHS and Social Care Partnership Trust, Maidstone, Kent
Conditions: Psychosis
SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis
Recruiting
The study seeks to investigate safety and efficacy of ixazomib (NINLARO), a proteasome inhibitor, in multiple sclerosis (MS). Participants will receive either ixazomib capsules or placebo capsules for up to 24 months.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/20/2024
Locations: Royal London Hospital, Barts Health NHS Foundation Trust, London, Greater London
Conditions: Relapsing Remitting Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
Recruiting
This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2. The main goals of this study are to:
* Find the recommended dose(s) of BT5528 that can be given safely to participants alone and in combination with nivolumab
* Learn more about the side effects of BT5528
* Learn about how effective BT5528 is for the treatment of ovarian cancer, urothelial/bladder cancer, lung cance... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: California Cancer Associates for Research and Excellence, Inc., Encinitas, California +31 locations
Conditions: Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer, Head and Neck Cancer, Triple Negative Breast Cancer, Gastric/Upper Gastrointestinal Cancer
London Valvular Heart Disease and Reduced Ejection Fraction Detection in a Multi-ethnic Community Using Cardiac Ultrasound
Recruiting
Heart Valve Disease and Heart failure contribute to 25% of hospital emergency admissions while heart failure alone has become one of the most common causes for hospitalisation in people over the age of 65. The burden of disease is likely to be high in a multi-ethnic community but there is a paucity of data. Management of heart valve disease requires appropriate surveillance and timely surgery. Similarly heart failure management requires treatment with medications aimed at slowing prevention of s... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
11/20/2024
Locations: St Bartholomews Hospital, London, Not set
Conditions: Heart Valve Diseases, Left Ventricular Dysfunction
Investigate and Predict Aortic & Thoracic Surgery Persistenet Postsurgical Pain
Recruiting
This is an observational clinical study aiming to further the wider understanding of patients who develop persistent pain after Thoracoabdominal Aorta surgery, a surgical cohort who are disproportionately affected. This will be undertaken through a prospective biopsychosocial characterisation of the phenotype of patients undergoing this operation.
Increasing numbers of patients are undergoing surgery on the chest for treatment of heart or lung cancer disease. Over the last twenty years, the med... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: St Bartholomew's Hospital, London, Not set
Conditions: Persistent Postsurgical Pain
Air Pollution and Pregnancy
Recruiting
We are an inter-disciplinary team of UK scientists with expertise in obstetrics, women's and child health, epidemiology, climate science, inflammation, computational modelling, machine learning and artificial intelligence. Together we have a long history with existing strengths underlying preterm birth research that crosses multiple disciplines and an excellent track record of publications and awards leading research in preterm birth.
We aim to develop and validate a deep learning model to pred... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Tina Chowdhury, London, Not set +1 locations
Conditions: Premature Birth
MEMRI and Kidney Disease
Recruiting
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD). Cardiovascular disease is an important complication of AKI.2 Similar to AKI, CKD and kidney transplantation and kidney donation associations with cardiovascular disease.1 The risk of cardiovascular disease complications is also increased in patients with inflammatory diseases that affect the kidneys, such... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: NHS Lothian, Edinburgh, Not set
Conditions: Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
Mucopolysaccharidosis I (MPS I) Registry
Recruiting
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities.
The objectives of the Registry are:
* To evaluate the lon... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Phoenix Children's Hospital- Site Number : 840003, Phoenix, Arizona +179 locations
Conditions: Mucopolysaccharidosis I (MPS I)
1993 - 2004 of 3097
