Non-invasive Continuous Cardiac Output Monitoring in Preterm Infants Study
NCT04064177
Recruiting
This is an observational study in newborn term and preterm infants. The study will validate if non-invasive continuous cardiac output monitoring is feasible in newborn infants, if normative values can be constructed and what is the effect of fluid boluses and inotropes on cardiac output and peripheral vascular resistance.
Gender:
ALL
Ages:
Between 1 hour and 40 weeks
Trial Updated:
07/26/2024
Locations: Imperial College Healthcare NHS Trust, London, Not set
Conditions: Cardiac Output, Low, Cardiac Output, High, Blood Pressure
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Bioimpedence and Arterial Function Monitoring at Birth and in Infants
NCT04720690
Recruiting
Babies may be born appropriately grown for gestational age (AGA, \>10th centile) or small for gestational age (SGA, \<10th centile). Babies who are SGA and have evidence in utero of vascular compromise using antenatal doppler indices are classified as having fetal growth restriction (FGR). Babies with FGR are at increased risk of cardiovascular disease in adult life. Increased arterial stiffness and intima-media thickness are thought to mediate this risk in adults. It is not known how early in l... Read More
Gender:
ALL
Ages:
6 months and below
Trial Updated:
07/26/2024
Locations: Queen Charlotte's and Chelsea Hospital, London, Not set +1 locations
Conditions: Arterial Stiffness, Fetal Growth Retardation, Small for Gestational Age at Delivery, Pre-Eclampsia
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Structured Tailored Rehabilitation After Hip Fragility Fracture
NCT06014554
Recruiting
Why the investigators are doing this study? The best approach to rehabilitation after a broken hip is not known. A new approach could improve outcomes by tailoring rehabilitation to patient needs. This approach identifies subgroups of patients within a population who have different risks of poor outcomes. These subgroups are then matched to treatments better tailored to their needs. Survivors of a broken hip describe a tailored approach as key to recovery. Further, the NHS recommends this approa... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/26/2024
Locations: St Thomas Hospital, London, Not set
Conditions: Hip Fractures
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The ReVo Study: Low-volume vs High-volume Rectal Irrigation
NCT06100055
Recruiting
Rectal irrigation, which is the introduction of warm tap water through the anal canal into the rectum to initiate defaecation, is recommended to be considered in patients with chronic constipation, which is refractory to conservative measures such as lifestyle modification, laxatives, nurse-led bowel retraining programmes which focuses on bio-feedback as well as psychosocial support. Two systems of rectal irrigation are available based on volume delivered, low and high volume. It is unknown if... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/26/2024
Locations: St Thomas' Hospital, London, Not set
Conditions: Constipation - Functional, Constipation, Constipation by Outlet Obstruction, Defecation Disorder
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Cerebral Oxygen Saturation Monitoring During Optimum Cord Management in Preterm Infants
NCT06526091
Recruiting
This study will assess the feasibilty measuring cerebral oxygen saturations using a Near Infrared Spectroscopy (NIRS) monitor immediately after delivery of preterm infants. The investigators aim to evaluate the effects of optimum cord management on cerebral oxygenation in this cohort
Gender:
ALL
Ages:
Between 1 minute and 24 hours
Trial Updated:
07/26/2024
Locations: Imperial College Healthcare NHS Trust, London, Not set
Conditions: Pre-Term
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ZNN Bactiguard Antegrade Femoral Nails PMCF Study
NCT05339360
Recruiting
This is a multicenter, prospective, Post-market Clinical Follow-up (PMCF) Study on the ZNN Bactiguard Antegrade Femoral Nails. The objective of this study is to collect data confirming the safety, performance, and clinical benefit of the study device and instrumentation when used for the temporary internal fixation and stabilization of femoral fractures and osteotomies. This is a CE-marked device already available on the market and the aim of the study is to comply with the post-market surveill... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2024
Locations: Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Not set +1 locations
Conditions: Femur Fracture, Osteotomy
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Advanced Sensor Based Functional ASsessmenTs in Axial Spondyloarthritis
NCT04489342
Recruiting
This is an observational study using Inertial Measurement Unit (IMU) sensors to measure the effects of biological therapy on spinal mobility and function in axial spondyloarthritis. Participants will undergo MRI scans before and after therapy in parallel to the sensor tests to establish correlation between changes in inflammatory signs and changes in spinal mobility.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/24/2024
Locations: Department of Rheumatology, Altnagelvin Hospital, Londonderry, N.Ireland
Conditions: Axial Spondyloarthritis
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A Game-based Neurodevelopmental Assessment for Young Children
NCT05780853
Recruiting
The aim of this study is to evaluate a novel tablet game-based neurodevelopmental assessment tool for young children aged 3 to 8 years old. The study's main aims are: (1) to determine whether the novel tablet-game based assessment tool can accurately differentiate children's neurodevelopmental status based on their performance on the game and (2) assess the validity of the game-based neurodevelopment assessment tool. The study aims to recruit 590 children who are 'typically' developing and/or... Read More
Gender:
ALL
Ages:
Between 3 years and 8 years
Trial Updated:
07/24/2024
Locations: Brightlobe Limited, London, Not set
Conditions: Neurodevelopmental Disorders, Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Dyslexia, Specific Learning Disorder, Child Development
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Laser Speckle Imaging During Breast Reconstruction
NCT06523452
Recruiting
Around 3500 women a year have surgery to reconstruct a breast/s after cancer. Breast reconstruction can have a positive impact on their lives, but unfortunately 3 or 4 in 10 women have problems with healing after their operation. This is distressing and often leads to more medical care or surgery. These problems are often caused by poor blood flow to the skin and deeper tissues used to reconstruct the breast. The investigators have developed a new device that does not touch the skin and provides... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/23/2024
Locations: Royal Devon University Healthcare NHS Foundation Trust, Exeter, Devon
Conditions: Breast Cancer
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Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
NCT02227251
Recruiting
A multicenter, open-label Phase 2b study of selinexor (KPT-330) in participants with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who have no therapeutic options of demonstrated clinical benefit.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2024
Locations: UACC Arizona, Tucson, Arizona +175 locations
Conditions: Diffuse Large B-cell Lymphoma
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Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma
NCT03222635
Recruiting
Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or HR T1aN0M0 EAC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2024
Locations: Westmead hospital, Sydney, Not set +19 locations
Conditions: Submucosal Esophageal Adenocarcinoma, Barrett Esophagus, High-risk Mucosal Esophageal Adenocarcinoma
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UK SMA Patient Registry
NCT04292574
Recruiting
Spinal muscular atrophy (SMA) is a form of motor neuron disease, most commonly caused by a mutation in the survival motor neuron 1 gene (SMN1) which results in a wide disease spectrum affecting children and adults. It is an autosomal recessive disorder and is therefore caused by inheritance of a mutated gene from each parent. All forms of SMA have an estimated combined incidence of 1 in 6,000 to 1 in 10,000 live births, with a carrier frequency of 1/40 to 1/60. The patient registry aims to faci... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/22/2024
Locations: John Walton Muscular Dystrophy Research Centre, Newcastle upon Tyne, Not set
Conditions: Spinal Muscular Atrophy, SMA
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