Machine Learning Miscarriage Management Clinical Decision Support Tool Study
NCT06384144
Recruiting
Machine learning used to develop an algorithm to determine chance of success with expectant or medical management for an individual patient. Taking into account the following objective measures: * Demographics: Maternal Age, Parity * History: Previous CS, Previous SMM/MVA, Previous Myomectomy * Gestation by LMP * Presenting symptoms: Bleeding score, Pain score * USS Measurements: CRL, GS, RPOC 3 dimensions, Vascularity * Discrepancy between gestation by CRL and LMP Audit to collate 1000 cases... Read More
Gender:
FEMALE
Ages:
Between 16 years and 55 years
Trial Updated:
04/22/2024
Locations: Imperial College Heatlhcare NHS Trust, London, Not set
Conditions: Miscarriage in First Trimester
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Dose De-escalation in Prostate Radiotherapy Using the MRL
NCT05709496
Recruiting
The goal of this feasibility study is to learn about dose de-escalation in the treatment of men with intermediate risk prostate cancer. The main question it aims to answer is the technical feasibility of treating prostate cancer with toxicity-minimising radiotherapy on an Magnetic Resonance Linear Accelerator (MR-linac). It will also examine gastrointestinal and genitourinary toxicity in the acute and late setting post radiotherapy as well as Prostate-Specific antigen (PSA) control up until 2 y... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: The Royal Marsden Hospital, Sutton, Surrey
Conditions: Prostate Adenocarcinoma
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Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial
NCT02699645
Recruiting
An investigator initiated and conducted, multicentre, international, double-blinded, placebo-controlled, parallel-group, randomised controlled trial to determine the effect of more intensive blood pressure control provided by a fixed low-dose combination blood pressure lowering pill ("Triple Pill") strategy on top of standard of care, on time to first occurrence of recurrent stroke in patients with a history of stroke due to intracerebral haemorrhage.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Liverpool Hospital, Liverpool, New South Wales +64 locations
Conditions: Hypertension, Intracerebral Haemorrhage (ICH)
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Traditional Dietary Advice Versus Reassurance-alone in Postprandial Functional Dyspepsia
NCT05718960
Recruiting
Functional dyspepsia is common, affecting 7.2% of the global population, and associated with substantial health impairment. Almost 80% of patients with functional dyspepsia report meal-related symptoms and are classified as having the postprandial distress syndrome (PDS) variant. However, studies evaluating dietary modifications in PDS are sparse. The investigators will perform a single-centre randomised trial evaluating traditional dietary advice (TDA) in PDS. 50 patients with PDS will be ran... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/18/2024
Locations: Royal Hallamshire Hospital, Sheffield, South Yorkshire
Conditions: Dyspepsia, Functional Gastrointestinal Disorders
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Traditional Dietary Advice Versus Low FODMAP Diet in Postprandial Functional Dyspepsia
NCT05810168
Recruiting
Functional dyspepsia is common, affecting 7.2% of the global population, and associated with substantial health impairment. Almost 80% of patients with functional dyspepsia report meal-related symptoms and are classified as having the postprandial distress syndrome (PDS) variant. However, studies evaluating dietary modifications in PDS are sparse. The investigators will perform a randomised trial evaluating traditional dietary advice (TDA) vs. a diet low in fermentable fermentable oligo-, di-,... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/18/2024
Locations: Royal Hallamshire Hospital, Sheffield, South Yorkshire
Conditions: Dyspepsia, Functional Gastrointestinal Disorders
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Role of Cytosorb in Left Ventricular Assist Device Implantation
NCT04596813
Recruiting
Mechanical circulatory support, specifically implantable continuous flow left ventricular assist device (CF-LVAD) therapy has been established as a viable treatment for rapidly deteriorating patients suffering from end stage heart failure either as bridge or alternative to heart transplantation. However, a large proportion of these patients experience severe complications in the early postoperative period including right ventricular failure or multi organ failure leading to increased mortality.... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/17/2024
Locations: Harefield Hospital, Harefield, Not set
Conditions: Heart Failure
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Multi-organ Responses to CHronic Physical Activity and INactivity
NCT06377254
Recruiting
Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual. Persistent physical inactivity is thought to be a key contributing factor to the risk of poor health and functional decline occurring in middle-aged and older adults. It is therefore concerning that most middle-aged adults spend \>8hrs/da... Read More
Gender:
ALL
Ages:
Between 55 years and 65 years
Trial Updated:
04/17/2024
Locations: David Greenfield Human Physiology Unit, Nottingham, Notts
Conditions: Sedentary Behavior, Metabolic Syndrome, Age-related Cognitive Decline, Age-Related Sarcopenia
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Phase I/II Clinical Trial Stem Cell Gene Therapy in RAG1-Deficient SCID
NCT04797260
Recruiting
This study is a prospective, non-randomized, open-label, two-centre phase I/II intervention study designed to treat children up to 24 months of age with RAG1-deficient SCID with an indication for allogeneic hematopoietic stem cell transplantation but lacking an HLA-matched donor. The study involves infusion of autologous CD34+ cells transduced with the pCCL.MND.coRAG1.wpre lentiviral vector (hereafter called RAG1 LV CD34+ cells) in five patients with RAG1-deficient SCID.
Gender:
ALL
Ages:
Between 8 weeks and 24 months
Trial Updated:
04/17/2024
Locations: The Royal Childrens Hospital, Melbourne, Not set +6 locations
Conditions: Severe Combined Immunodeficiency Due to RAG1 Deficiency
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Ocular Microtremor in Parkinson's Disease.
NCT06051877
Recruiting
This is an exploratory, observational study that will use a novel handheld device - The iTremor ONE, which has been developed to rapidly, non-invasively assess and evaluate OMT frequency. This device uses incident laser technology directed at the sclera. PwPD who meet the inclusion criteria will participate in a home-based assessment involving cognitive, motor (using the UPDRS-III) and OMT measures. With OMT as the primary outcome, assessment with the iTremor is incredibly quick, taking just thr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Gateshead Health NHS Foundation Trust, Gateshead, Tyne And Wear +1 locations
Conditions: Parkinson's Disease, Parkinson Disease
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Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis
NCT05201638
Recruiting
Multi-Center, Randomized, Double-Blinded Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 versus Placebo in Adults with Relapsing Multiple Sclerosis (ENSURE-2)
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/17/2024
Locations: HonorHealth Research Institute - Bob Bove Neuroscience Institute, Scottsdale, Arizona +90 locations
Conditions: Multiple Sclerosis, Relapsing-Remitting
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Changes in Muscle Strength, Inflammatory Markers, and Body Composition in Response to Alternate Day Fasting Combined With Krill Oil Supplementation in Adults With Overweight and Obesity
NCT06001632
Recruiting
The goal of this double-blind, randomised, controlled trial is to determine the effects of LC n-3 PUFAs supplementation on changes in body composition and muscle strength during body weight loss and body weight maintenance among healthy adults living with overweight and obesity. The main research questions: * Is supplementation with LC n-3 PUFAs during dietary weight loss intervention (alternative-day fasting) attenuate the reduction in fat-free mass and muscle strength? * Is supplementation wi... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
04/17/2024
Locations: University of Glasgow, New Lister Building, Glasgow, Scotland
Conditions: Obesity Associated Disorder
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Impact of Macronutrient Composition of Energy-restricted Diet and Exercise on Body Composition and Appetite Hormones.
NCT06022315
Recruiting
The main aim of this study is to investigate the effect of energy-restricted low and high-carbohydrate diet combined with exercise training on appetite regulatory hormones, subjective appetite and energy intake in overweight and obese women. In addition, since the macronutrient composition of meals and exercise impacts biomarkers of cardiovascular disease, the impact of these interactions on metabolic risk factors of cardiovascular diseases will also be investigated .
Gender:
FEMALE
Ages:
Between 25 years and 45 years
Trial Updated:
04/17/2024
Locations: Human Nutrition, College of Medicine, Veterinary and Life Science, Glasgow, Not set
Conditions: Gastrointestinal Hormones
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