Exogenous Ketosis in a Fed and a Fasted State
NCT06320522
Recruiting
The kinetics of circulating βHB following ingestion of the ketone monoester are dependent on several variables that determine the balance between appearance into, and disappearance from, the bloodstream. These dynamics have been well characterised in fasted humans but in the real world the ketone monoester is likely to be ingested in a fed state, pertinently within athletic spheres consumption would proceed a substantial high-carbohydrate meal. Within this, it is unclear how metabolism under exo... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/12/2024
Locations: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Oxford, Oxfordshire
Conditions: Ketosis, Exogenous Ketosis
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Cardiac Rehabilitation Participation and South Asian Service Users
NCT06239558
Recruiting
The goal of this qualitative study is to learn about the barriers and enablers to cardiac rehabilitation, experience by South Asian service users based in the UK who have experienced an acute cardiac event and been referred for CR. This may allow NHS programmes to make adaptations to their services to enhance uptake, adherence and completion for this ethnic population. The main questions it aims to answer are: * What are the barriers and enablers to uptake, adherence or completion of CR experie... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: Glenfield General Hospital, Leicester, Leicestershire
Conditions: Cardiac Rehabilitation, South Asian Service Users
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Physical Activity, Knee Joint Loading and Joint Health
NCT05306054
Recruiting
The purpose of this study is to investigate the association between time spent in moderate to vigorous physical activity and markers of cartilage metabolism in the years following anterior cruciate ligament reconstruction.
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
03/12/2024
Locations: University of Bath, Bath, Not set
Conditions: Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Post-traumatic Osteoarthritis, Anterior Cruciate Ligament Reconstruction
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Determinants of Progression From Phase III to IV Cardiac Rehabilitation
NCT05784272
Recruiting
This study will determine the limiting factors in progression from phase III to IV cardiac rehabilitation in underepresented populations (as defined by the National Audit of Cardiac Rehab, NACR). This will be done by recruiting participants from phase III cardiac rehab programmes and issuing questionnaires (either a non-initiator questionnire, or an initiator questionnaire based on if the participant is intiating into phase IV cardiac rehab. The questionnaires will assess reasons for/against pro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Aneurin Bevan University Hospital, Caerleon, Gwent +2 locations
Conditions: Cardiovascular Diseases
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Umbilical Cord Abnormalities in the Prediction of Adverse Pregnancy Outcomes
NCT05901688
Recruiting
The objective of our study is to investigate the association of umbilical cord abnormalities with adverse pregnancy outcomes. The umbilical cord parameters that will be investigated as part of this study include the umbilical cord coiling index (UCI), umbilical cord (UC) diameter, umbilical vein (UV) diameter, UV flow velocity and the presence of nuchal cord. The UCI, UC, UV diameter \& flow and presence of nuchal cord will be measured in routine unselected populations at 20-22 weeks and 35-37 w... Read More
Gender:
FEMALE
Ages:
16 years and above
Trial Updated:
03/11/2024
Locations: Medway NHS Foundation Trust, Gillingham, Kent
Conditions: Small for Gestational Age at Delivery, Hypoxic-Ischemic Encephalopathy, Stillbirth, Admission to Neonatal Unit
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LOWER: Lomitapide Observational Worldwide Evaluation Registry
NCT02135705
Recruiting
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: Brookwood Baptist Medical Center, Birmingham, Alabama +74 locations
Conditions: Homozygous Familial Hypercholesterolemia
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The Effectiveness of Electronic Reminders in Improving Elastic Compliance in Orthodontic Patients
NCT03144323
Recruiting
Fixed orthodontic appliances in combination with intraoral elastics are a common and effective method use in the orthodontic correction of malocclusions. However, their success is largely dependent on the patient's compliance. Failure to wear the elastics as instructed will reduce efficacy of treatment, ultimately increasing treatment time and potentially producing imperfect alignment of teeth. The hypothesis tested is that daily electronic reminders via a mobile application can significantly i... Read More
Gender:
ALL
Ages:
Between 10 years and 20 years
Trial Updated:
03/08/2024
Locations: Guy's Hospital, London, Not set +1 locations
Conditions: Malocclusion, Compliance, Patient
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Effect of a Community Exercise Programme on Stroke Patients
NCT05320549
Recruiting
Physical activity is known to be beneficial for supporting health and wellbeing. A number of schemes and strategies have been developed to improve uptake of physical activity in the United Kingdom (UK) population, including the 'Everybody active, every day' framework. This framework includes recommendations for referral from a healthcare professional for people to become more active. For those with an existing health condition or other risk factors that could lead to health problems, such referr... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
03/08/2024
Locations: University of Winchester, Winchester, Not set
Conditions: Stroke
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CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia)
NCT04678869
Recruiting
CiproPAL is a randomised trial comparing daily ciprofloxacin with local standard care during the induction phase of paediatric ALL treatment, and aims: 1. To assess the efficacy of ciprofloxacin prophylaxis in the reduction of infection during the induction phase of treatment for paediatric Acute Lymphoblastic Leukaemia within the ALLTogether-1 Trial. 2. To evaluate the impact of ciprofloxacin prophylaxis on antimicrobial resistance, both of invasive infections and colonising organisms.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
03/07/2024
Locations: Royal Aberdeen Children's Hospital, Aberdeen, Not set +13 locations
Conditions: Acute Lymphoblastic Leukaemia - Category
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Personalised Cancer Care and Support: Identifying What Good Looks Like
NCT05702684
Recruiting
The overarching aim is to study the coproduction of personalised care in a digital age by seeking to improve the experience of care and personalised care and support planning for people who live with and beyond colorectal cancer. This study will assess digital health contributions to personalised care and explore how to improve the quality of collaborative digital care planning in cancer services. The electronic holistic needs assessment (eHNA) developed by Macmillan Cancer Support (macmillan.or... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Guy's & St Thomas' NHS Foundation Trust, London, Not set
Conditions: Colorectal Cancer
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Low-dose Tolvaptan for Inpatient Hyponatraemia.
NCT06171100
Recruiting
This is a retrospective cohort study to assess the safety and efficacy of low first dose of Tolvaptan and low or standard second dose of Tolvaptan in patients with moderate to severe hyponatraemia associated with SIADH not responding to conservative means of hyponatraemia management. Patients are treated as part of standard clinical care. There is growing evidence that treating patients with SAIDH induced hyponatraemia using a low dose of Tolvaptan with 7.5mg (below licensed lowest 15mg daily d... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/07/2024
Locations: King's College Hospital NHS Foundation Trust, London, Not set
Conditions: Hyponatremia, SIADH
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Mechanisms of Multi-organ Failure in COVID-19
NCT04399603
Recruiting
In the United Kingdom, there are currently 138,000 confirmed patients with coronavirus, causing 18,738 deaths. Whilst the disease may be mild in the majority of patients, a significant proportion of patients require intensive care therapy and a ventilator due to lung injury. In addition to lung injury/failure (acute respiratory distress syndrome (ARDS)), around 50% of patients admitted to intensive care develop acute kidney injury (AKI) (requiring advanced support via haemofiltration) and multi-... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/06/2024
Locations: Chelsea and Westminster Hospital NHS Foundation Trust, London, Not set +1 locations
Conditions: COVID
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