Mechanisms of Multi-organ Failure in COVID-19
NCT04399603
Recruiting
In the United Kingdom, there are currently 138,000 confirmed patients with coronavirus, causing 18,738 deaths. Whilst the disease may be mild in the majority of patients, a significant proportion of patients require intensive care therapy and a ventilator due to lung injury. In addition to lung injury/failure (acute respiratory distress syndrome (ARDS)), around 50% of patients admitted to intensive care develop acute kidney injury (AKI) (requiring advanced support via haemofiltration) and multi-... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/06/2024
Locations: Chelsea and Westminster Hospital NHS Foundation Trust, London, Not set +1 locations
Conditions: COVID
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Trans & Non-binary Reference Intervals While on Hormone Therapy Study
NCT04478760
Recruiting
This study will find out what the reference intervals are for common blood tests in transgender people taking hormone therapy. Reference intervals help doctors interpret blood test results. They are expressed as two numbers, and most normal results fall between them. If a results fall outside of them, it may be because of a disease. Some blood tests are also affected by normal difference between people, such as age, sex or ethnicity. For these tests, different reference intervals are given for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2024
Locations: Caldecot Centre, King's College Hospital, 15-22 Caldecot Road, London, Not set
Conditions: Transgender Persons, Hormone Replacement Therapy, Reference Values
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vHDU Phase 5: Impact of an Ambulatory Monitoring System on Deterioration Detection and Clinical Outcomes
NCT05118477
Recruiting
Sometimes in hospital, it is not noticed that patients are becoming unwell quickly enough. This may mean that they are less likely to survive than if the worsening of their illness had been picked up sooner. One reason for this may be that hospital staff are unable to check patients' vital signs (such as breathing rate, heart rate and level of oxygen in their blood) frequently enough to help them decide if a patient is becoming more unwell. Currently, for nurses to watch these vital signs closel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2024
Locations: Oxford University Hospitals Trust, Oxford, Oxfordshire
Conditions: Surgery, Deterioration, Clinical
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A Randomised Open-label Phase III Trial of REduced Frequency Pembrolizumab immuNothErapy for First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
NCT05085028
Recruiting
REFINE-lung will test whether reduced pembrolizumab dose frequency after 6 months of standard treatment is safe and effective. Patients treated with 1st line pembrolizumab who are progression free and otherwise planning to continue therapy at 6 months will be initially randomised to control 6 weekly versus interventional 12 weekly therapy. If an interim analysis shows that the 12 weekly treatment is no less effective, subsequent patients will also be randomised to 9, 15 and 18 weekly treatment f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2024
Locations: Royal Bournemouth Hospital, Bournemouth, Not set +36 locations
Conditions: Lung Cancer, Nonsmall Cell
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Cardiac Rehabilitation for Young People
NCT05968521
Recruiting
Heart problems are amongst the most common physical illnesses in children and young people (CYP). They can be present from birth or develop as CYP get older and are linked to increased physical and psychological difficulties overprotection from caregivers and healthcare providers and reduced quality of life. While adults are offered exercise classes and lifestyle advice after a heart problem, CYP with heart problems are not. Improving health behaviours in people with heart problems is vital, im... Read More
Gender:
ALL
Ages:
Between 11 years and 16 years
Trial Updated:
03/06/2024
Locations: Manchester University NHS Foundation Trust, Manchester, Not set
Conditions: Congenital Heart Disease, Cardiomyopathies, Cardiac Arrythmias, Heart Failure, Cerebrovascular Event, Heart Valve Diseases
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A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD
NCT06236880
Recruiting
The aim of this Phase 2a study in patients with MDD is to assess safety and tolerability and preliminary antidepressant efficacy.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/06/2024
Locations: MAC Clinical Research, Manchester, Not set
Conditions: Major Depressive Disorder
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A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567
Recruiting
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/05/2024
Locations: Phoenix Childrens Hospital -1919 E Thompson Rd, Phoenix, Arizona +67 locations
Conditions: Ulcerative Colitis, Crohn's Disease
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Imaging of Endolymphatic Hydrops at 7T MRI
NCT04370366
Recruiting
Imaging endolymphatic hydrops with 7T Sodium Imaging and 1.5 T gadolinium enhanced imaging: a comparison of diagnostic outcomes with 3T MRI Duration of study 24 months Study design Prospective cohort study Number of patients 16 patients 1. To evaluate whether imaging both 1.5T and 3T have an equivalent performance in terms of diagnosing MD ears with delayed post gadolinium enhanced MRI (applying quantitative and semi-quantitative analysis) 2. To compare the diagnostic performance of Sodium I... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: King's College London, London, Not set
Conditions: Meniere Disease
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The Heart Hive - Cardiomyopathy Study
NCT04612296
Recruiting
This is an online registry and database of patients with cardiomyopathy and myocarditis, coupled with an observational study of DCM and HCM.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: Imperial College London, London, Not set
Conditions: Cardiomyopathies, Myocarditis
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The SMARTER Cardiomyopathy Study
NCT05750147
Recruiting
Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses. Finding new ways to diagnose and treat cardiomyopathies could improve the health and well-being of patients with these conditions. This study will collect data from individuals with cardiomyopathy or related heart muscle disease, or with a possible genetic predispositio... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/05/2024
Locations: Guys & St Thomas' NHS Foundation Trust, London, Not set +1 locations
Conditions: Cardiomyopathies, Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy
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Trial Of Neurostimulation Treatment and Investigation for Causes of Functional Motor Symptoms: a Pilot Study
NCT05829005
Recruiting
A pilot randomised controlled trial (RCT) of single-pulse transcranial magnetic stimulation (TMS) over the motor cortex to investigate efficacy in improving motor FND symptoms and to make a preliminary investigation of predictors of response to TMS and potential mechanisms of action.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2024
Locations: Institute of Psychiatry, Psychology & Neuroscience, London, Not set
Conditions: Functional Neurological Symptom Disorder
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Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
NCT06014138
Recruiting
This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU). There are different approaches to sedation which may have advantages and disadvantages. During the study patients will receive both intravenous and inhaled volatile sedation (similar to anaesthetic 'gases' used for general anaesthesia) and the drive to breath, breathing efforts and function of the lung will be assessed.
Gender:
ALL
Ages:
17 years and above
Trial Updated:
03/05/2024
Locations: Guy's & St Thomas' NHS Foundation Trust, London, Not set
Conditions: Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Sedation Complication
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