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All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
Recruiting
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer).
This study is seeking participants who:
* Are 18 years of age or older and have MM.
* Have received treatments before for MM.
* Have MM that has returned or not responded to their most recent treatment.
Half of the participants will receive elranatamab. The other half of participants will receive a combination t... Read More
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer).
This study is seeking participants who:
* Are 18 years of age or older and have MM.
* Have received treatments before for MM.
* Have MM that has returned or not responded to their most recent treatment.
Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM.
Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study.
The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as:
* a shot under the skin at the study clinic
* through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects.
Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits).
The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Infirmary Cancer Care, Mobile, Alabama +229 locations
Infirmary Cancer Care, Mobile, Alabama
Western Regional Medical Center, Inc. dba. City of Hope Phoenix, Goodyear, Arizona
Beverly Hills Cancer Center, Beverly Hills, California
Community Cancer Institute, Clovis, California
Clinical Research Advisors (Encino Satellite Location), Encino, California
Hoag Health Center Irvine, Irvine, California
Hoag Hospital Irvine, Irvine, California
Clinical Research Advisors (Korea Town Satellite Location), Los Angeles, California
Clinical Research Advisors (West Hollywood Satellite Location), Los Angeles, California
Valkyrie Clinical Trials, Los Angeles, California
Hoag Memorial Hospital Presbyterian, Newport Beach, California
Mission Community Hospital (Satellite Site), Panorama City, California
University of California Davis (UC Davis) Comprehensive Cancer Center, Sacramento, California
University of California, Sacramento, California
UCHealth Poudre Valley Hospital, Fort Collins, Colorado
PET Imaging of Northern Colorado, Fort Collins, Colorado
UCHealth Harmony, Fort Collins, Colorado
UCHealth Greeley Hospital, Greeley, Colorado
UCHealth Longs Peak Hospital, Longmont, Colorado
UCHealth Longs Peak Medical Center, Longmont, Colorado
UCHealth - Medical Center of the Rockies, Loveland, Colorado
Baptist Hospital of Miami, Miami, Florida
BRCR Global, Plantation, Florida
BRCR Global - Tamarac, Tamarac, Florida
Midwestern Regional Medical Center, Inc. dba City of Hope Chicago, Zion, Illinois
Community Health Network, Inc., Indianapolis, Indiana
Community Health Network, Inc., Indianapolis, Indiana
Community Health Network, Inc., Indianapolis, Indiana
Beth Israel Deaconess Medical Center, Boston, Massachusetts
BIDMC Research Pharmacy, Boston, Massachusetts
Bryan Medical Center, Lincoln, Nebraska
NHO Revive Research Institute, LLC, Lincoln, Nebraska
Atlantic Health System Morristown Medical Center, Morristown, New Jersey
WMCHealth Advanced Physician Services, Hawthorne, New York
Cayuga Cancer Center at Cayuga Park, Ithaca, New York
Cayuga Medical Center, Ithaca, New York
Westchester Medical Center, Valhalla, New York
Brody school of Medicine at East Carolina University, Greenville, North Carolina
ECU Health Medical Center, Greenville, North Carolina
Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio
TriHealth Cancer Institute-Good Samaritan Hospital, Cincinnati, Ohio
Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio
The Jewish Hospital, Cincinnati, Ohio
Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio
Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio
Cleveland Clinic, Cleveland, Ohio
AHN West Penn Hospital, Pittsburgh, Pennsylvania
Brown University Health Cancer Institute, Providence, Rhode Island
The Miriam Hospital, Providence, Rhode Island
St Francis Cancer Center, Greenville, South Carolina
Baylor University Medical Center, Investigational Drug Services, Department of Pharmacy, Dallas, Texas
Baylor University Medical Center, Dallas, Texas
Houston Methodist Hospital, Houston, Texas
Houston Methodist Willowbrook Hospital, Houston, Texas
US Oncology Investigational Products Center (IPC), Irving, Texas
Houston Methodist Sugar Land Hospital, Sugar Land, Texas
Baylor Scott & White Medical Center - Temple, Temple, Texas
WVU Cancer Institute, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center-University Hospital, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires
Hospital Universitario Austral, Pilar, Buenos Aires
Hospital Italiano de Buenos Aires, Ciudad de Buenos Aires, Ciudad Autónoma DE Buenos Aires
Hospital Italiano de La Plata, La Plata, Not set
Blacktown Hospital, Blacktown, New South Wales
Concord Repatriation General Hospital, Concord, New South Wales
Sunshine Coast University Hospital, Birtinya, Queensland
Royal Brisbane and Women's Hospital, Brisbane, Queensland
St Vincent's Hospital (Melbourne), Fitzroy, Victoria
Barwon Health, Geelong, Victoria
Clinique Saint Pierre, Ottignies, Brabant Wallon
UZ Brussel, Brussels, Bruxelles-capitale, Région DE
Grand Hôpital de Charleroi, Gilly, Hainaut
Centre Hospitalier Epicura, Hornu, Hainaut
CHR Verviers - La Tourelle, Verviers, Liège
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi, Yvoir, Namur
UZ Gent, Gent, Oost-vlaanderen
AZ Delta vzw, Roeselare, West-vlaanderen
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador, Salvador, Bahia
Instituto Oncomed de Educação e Pesquisa, Niterói, RIO DE Janeiro
Hospital Moinhos de Vento, Porto Alegre, RIO Grande DO SUL
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre, RIO Grande DO SUL
Centro de Pesquisa Clínica - Área Administrativa, Porto Alegre, RIO Grande DO SUL
Hospital Mae de Deus, Porto Alegre, RIO Grande DO SUL
Hospital Amaral Carvalho, Jau, SÃO Paulo
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP), Ribeirão Preto, SÃO Paulo
Instituto D'Or de Pesquisa e Ensino (IDOR), Sao Paulo, SÃO Paulo
Clínica Médica São Germano LTDA, SP, SÃO Paulo
Instituto de Educação, Pesquisa e Gestão em Saúde, Rio de Janeiro, Not set
Americas Centro de Oncologia Integrado, Rio de Janeiro, Not set
Instituto de Educação, Pesquisa e Gestão em Saúde, Rio de Janeiro, Not set
ESHO Empresa de Serviços Hospitalares S.A/ Hospital Samaritano de Higienópolis, São Paulo, Not set
Instituto D'Or de Pesquisa e Ensino (IDOR), São Paulo, Not set
Hospital do Coracao, São Paulo, Not set
HU UNIFESP / SPDM - Hospital São Paulo, São Paulo, Not set
Universidade Federal de Sao Paulo, São Paulo, Not set
Clínica Médica São Germano S/S Ltda, São Paulo, Not set
Cross Cancer Institute, Edmonton, Alberta
The Moncton Hospital, Moncton, New Brunswick
Jewish General Hospital, Montreal, Quebec
Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎ, Montreal, Quebec
Klinicki bolnicki centar Rijeka, Rijeka, Not set
University Hospital Center Zagreb, Zagreb, Not set
Klinicka bolnica Dubrava, Zagreb, Not set
Klinicka bolnica Merkur, Zagreb, Not set
Fakultní nemocnice Brno Bohunice, Brno, Brno-město
Fakultni nemocnice Olomouc, Olomouc, Olomoucký KRAJ
Fakultni nemocnice Kralovske Vinohrady, Prague, Praha 10
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Rigshospitalet, Copenhagen, Hovedstaden
Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland
Aalborg Universitetshospital, Syd, Aalborg, Nordjylland
Tampereen yliopistollinen sairaala, Tampere, Pirkanmaa
Oulun yliopistollinen sairaala, Oulu, Pohjois-pohjanmaa
Kuopion Yliopistollinen Sairaala, Kuopio, Pohjois-savo
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki, Uusimaa
Turku University Hospital, Turku, Varsinais-suomi
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice, Alpes-maritimes
CHU Bordeaux Haut-Leveque, Pessac, Aquitaine
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse, Haute-garonne
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Lorraine
Centre Hospitalier de Dunkerque, Dunkirk, Nord-pas-de-calais
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu, Nantes, Pays-de-la-loire
Hôpital NOVO, Cergy Pontoise, Val-d'oise
Hôpital NOVO, Pontoise, Val-d'oise
Henri Mondor Hospital, Créteil, Val-de-marne
CHD Vendee, La Roche-sur-Yon, Vendée
Centre Hospitalier de la Côte Basque, Bayonne, Not set
Centre Hospitalier du Mans, Le Mans, Not set
Hôpital Universitaire Necker Enfants Malades, Paris, Not set
Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris, Not set
Centre Hospitalier de Cornouaille, Quimper, Not set
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours, Not set
Centre Hospitalier Bretagne Atlantique, Vannes, Not set
Centre Hospitalier Bretagne Atlantique, Vannes, Not set
Universitaetsklinikum Freiburg, Freiburg, Baden-württemberg
Robert Bosch Krankenhaus GmbH, Stuttgart, Baden-württemberg
Universitaetsklinikum Ulm, Ulm, Baden-württemberg
Klinikum Nürnberg Nord, Nürnberg, Bayern
Universitätsklinikum Bonn, Bonn, Nordrhein-westfalen
Universitätsklinikum Jena, Jena, Thüringen
Vivantes Klinikum Am Urban, Berlin, Not set
Vivantes Klinikum Am Urban, Berlin, Not set
Medizinische Universität Lausitz - Carl Thiem, Cottbus, Not set
Asklepios Altona, Hamburg, Not set
St. Barbara-Klinik Hamm-Heessen, Hamm, Not set
Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Not set
University Hospital of Alexandroupolis, Alexandroupolis, Anatolikí Makedonía KAI Thráki
Evangelismos General Hospital of Athens, Athens, Attikí
Alexandra General Hospital of Athens, Athens, Attikí
"Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Kentrikí Makedonía
G. Papanikolaou General Hospital, Thessaloniki, Thessaloníki
University Hospital of Ioannina, Ioannina, Ípeiros
Soroka Medical Center, Be'er Sheva, Hadarom
Rabin Medical Center, Petah-Tikva, Hamerkaz
Sheba Medical Center, Ramat Gan, Hamerkaz
Sourasky Medical Center, Tel Aviv, Tell Abīb
Hadassah Medical Center, Jerusalem, Yerushalayim
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-romagna
P.O. San Carlo Borromeo- ASST SANTI PAOLO E CARLO, Milano, Lombardia
Azienda Ospedaliero Universitaria delle Marche, Ancona, Marche
Azienda Socio Sanitaria Ovest milanese, Legnano, Milano
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Piemonte
A.O.U. Policlinico Paolo Giaccone, Palermo, Sicilia
Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana
Azienda Ospedaliero Universitaria Pisana, Pisa, Toscana
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Istituto Europeo di Oncologia IRCCS, Milano, Not set
Ospedale Civile dello Spirito Santo, Pescara, Not set
Nagoya City University Hospital, Nagoya, Aichi
Toyohashi Municipal Hospital, Toyohashi, Aichi
Ehime Prefectural Central Hospital, Matsuyama, Ehime
Ogaki Municipal Hospital, Ogaki, Gifu
Gunma University Hospital, Maebashi, Gunma
National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma
Kobe City Medical Center General Hospital, Kobe, Hyogo
Iwate Medical University Hospital, Shiwa-gun Yahaba-cho, Iwate
Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka
Nippon Medical School Hospital, Bunkyo-ku, Tokyo
Japanese Foundation for Cancer Research, Koto, Tokyo
Yamanashi Prefectural Central Hospital, Kofu-shi, Yamanashi
Kagoshima University Hospital, Kagoshima, Not set
University Hospital,Kyoto Prefectural University of Medicine, Kyoto, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Okayama Rosai Hospital, Okayama, Not set
Yamagata University Hospital, Yamagata, Not set
Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [seoul]
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [seoul]
Samsung Medical Center, Seoul, Seoul-teukbyeolsi [seoul]
Maastricht UMC+, Maastricht, Limburg
Albert Schweitzer Ziekenhuis, locatie Dordwijk, Dordrecht, Zuid-holland
Akershus Universitetssykehus, Lørenskog, Akershus
St. Olavs Hospital, Trondheim, Sør-trøndelag
Sykehuset i Vestfold, Tønsberg, Vestfold
Oslo Universitetssykehus Ullevål, Oslo, Not set
2Ca Braga, Braga, Not set
Univerzitna nemocnica Martin, Martin, Zilinsky
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banska Bystrica, Not set
Institut Català d'Oncologia (ICO) - Badalona, Badalona, Barcelona [barcelona]
Hospital Universitari Mutua Terrassa, Terrassa, Barcelona [barcelona]
Hospital General Universitario Morales Meseguer, Murcia, Galicia [galicia]
Institut Català d'Oncologia (ICO) - Girona, Girona, Girona [gerona]
Hospital Universitario Infanta Leonor, Madrid, Madrid, Comunidad DE
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo, PAÍS Vasco
ASCIRES ECG Médica S.L, València, Valenciana, Comunitat
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario HM Sanchinarro, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Centro de Diagnóstico y Resonancia Magnética, Salamanca, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Universitari i Politecnic La Fe, València, Not set
Falu Lasarett, Falun, Not set
Universitetssjukhuset Örebro, Örebro, Örebro LÄN [se-18]
China Medical University Hospital, Taichung, Not set
Milton Keynes Hospital, Milton Keynes, Buckinghamshire
Glan Clwyd Hospital, Bodelwyddan, Denbighshire [SIR Ddinbych Gb-ddb]
Royal Bournemouth Hospital, Bournemouth, Dorset
Poole Hospital, Poole, Dorset
Eastbourne District General Hospital, Eastbourne, EAST Sussex
Queen Elizabeth Hospital Birmingham, Birmingham, England
Maidstone Hospital, Maidstone, Kent
St Bartholomew's Hospital, London, London, CITY OF
Guy's & St Thomas' NHS Foundation Trust, London, London, CITY OF
King's College Hospital, London, London, CITY OF
Hammersmith Hospital, London, London, CITY OF
Churchill Hospital, Oxford, Oxfordshire
Royal Stoke University Hospital, Stoke-on-Trent, Staffordshire
Royal Marsden Hospital (Sutton), London, Sutton
Kent and Canterbury Hospital, Canterbury, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Multiple Myeloma
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
Recruiting
The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine.
The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine. Read Less
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
08/13/2025
Locations: Ki Health Partners LLC DBA New England Institute for Clinical Research, Stamford, Connecticut +57 locations
Ki Health Partners LLC DBA New England Institute for Clinical Research, Stamford, Connecticut
NW FL Clinical Research Group, LLC, Gulf Breeze, Florida
A G A Clinical Trials, Hialeah, Florida
Axcess Medical Research, Loxahatchee Groves, Florida
University of South Florida, Tampa, Florida
University of Kentucky, Lexington, Kentucky
University of Maryland School of Medicine, Baltimore, Maryland
Michigan Head Pain and Neurological Institute, Ann Arbor, Michigan
Michigan State University - Department of Neurology, East Lansing, Michigan
Helen Devos Childrens' Hospital, Grand Rapids, Michigan
Dent Neurosciences Research Center Incorporated, Amherst, New York
True North Neurology, Commack, New York
OnSite Clinical Solutions, LLC - Randolph Rd - Charlotte - ClinEdge - PPDS, Charlotte, North Carolina
Childrens Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center - PIN, Cincinnati, Ohio
Road Runner Research Ltd, San Antonio, Texas
Marshall University Medical Center, Huntington, West Virginia
Children's Wisconsin - Milwaukee Campus, Milwaukee, Wisconsin
Hospital Privado de La Comunidad, Mar Del Plata, Buenos Aires
Expertia S.A- Mautalén Salud e Investigación, Ciudad Autónoma de Buenos Aires, Ciudad Autónoma De BuenosAires
Hospital de Niños de La Santisima Trinidad, Córdoba-Barrio Crisol, Córdoba
Instituto Médico Río Cuarto, Río Cuarto, Córdoba
INECO Neurociencias Oroño, Rosario, Santa Fe
Centro de Investigaciones Médicas Tucumán - PPDS, San Miguel de Tucuman, Tucumán
Vancouver Island Health Authority, Victoria, British Columbia
The Kids Clinic, Ajax, Ontario
London Health Sciences Centre -800 Commissioners Rd E, London, Ontario
IRCCS Ospedale Pediatrico Bambino Gesù - INCIPIT - PIN, Roma, Lazio
IRCCS Istituto Giannina Gaslini, Genova, Liguria
Ospedale San Raffaele S.r.l. - INCIPIT - PIN, Milano, Lombardia
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Lombardia
AO Brotzu - Clinica di Neuropsichiatria dell'Infanzia e dell'Adolescenza - INCIPIT - PIN, Cagliari, Sardegna
Azienda Ospedaliero Universitaria A Meyer - INCIPIT - PIN, Firenze, Toscana
Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara, Pisa, Toscana
Fondazione Istituto Neurologico Nazionale Casimiro Mondino IRCCS, Pavia, Not set
Centro de Investigacion Medico Biologica y de Terapia Avanzada S.C., Guadalajara, Jalisco
Clinical Research Institute SC-Mexico, Ampl San Lucas Tepetlacalco, México
ICARO Investigaciones en Medicina, S.A de C.V, Chihuahua, Not set
Instituto de Investigationes Clinicas para la Salud A.C., Durango, Not set
ULS de Almada-Seixal, EPE - Hospital Garcia de Orta, Almada, Setúbal
ULS de Santo António, EPE - Centro Materno Infantil Norte, Porto Covo, Setúbal
Centro Clínico Académico, Braga - Hospital de Braga, Braga, Not set
ULS de Coimbra, EPE - Hospital Pediátrico de Coimbra, Coimbra, Not set
ULS de São João, EPE - Hospital de São João, Porto, Not set
Childrens University Hospital, Belgrade, Not set
University Clinical Center Kragujevac, Kragujevac, Not set
University Clinical Center Nis, Nis, Not set
Children and Youth Health Care Institute of Vojvodina, Novi Sad, Not set
CHUVI - H.U. Alvaro Cunqueiro, Vigo, Pontevedra
Hospital Universitario Vall d'Hebron - PPDS, Barcelona, Not set
Hospital Clinico San Carlos, Madrid, Not set
Hospital Universitario Virgen del Rocio - PPDS, Sevilla, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Eskisehir Osmangazi Universitesi Tip Fakultesi Hastanesi, Eskisehir, Not set
Mersin University Medical Faculty, Mersin, Not set
Great Ormond Street Hospital - PPDS, London, London, City Of
James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk
Queen Elizabeth University Hospital - PPDS, Glasgow, Not set
Conditions: Migraine
Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
Recruiting
This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of AZD5305 when given in combination with new hormonal agents (NHAs) in patients with Metastatic Prostate Cancer.
This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of AZD5305 when given in combination with new hormonal agents (NHAs) in patients with Metastatic Prostate Cancer. Read Less
Gender:
MALE
Ages:
Between 18 years and 130 years
Trial Updated:
08/13/2025
Locations: Research Site, San Diego, California +26 locations
Research Site, San Diego, California
Research Site, Indianapolis, Indiana
Research Site, Detroit, Michigan
Research Site, Detroit, Michigan
Research Site, Syracuse, New York
Research Site, Philadelphia, Pennsylvania
Research Site, Myrtle Beach, South Carolina
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Camperdown, Not set
Research Site, Darlinghurst, Not set
Research Site, East Melbourne, Not set
Research Site, Heidelberg, Not set
Research Site, Melbourne, Not set
Research Site, St Leonards, Not set
Research Site, Candiolo, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Orbassano, Not set
Research Site, Padova, Not set
Research Site, Pavia, Not set
Research Site, Cambridge, Not set
Research Site, Glasgow, Not set
Research Site, Hampshire, Not set
Research Site, Manchester, Not set
Research Site, Newcastle Upon Tyne, Not set
Research Site, Plymouth, Not set
Conditions: Metastatic Prostate Cancer
Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy
Recruiting
The standard treatment for patients with acute myeloid leukemia (AML) with an abnormality in the IDH1 gene, who are not eligible for intensive chemotherapy, is a combination of ivosidenib and azacitidine. In this study it is investigated whether adding venetoclax to the standard treatment can improve the outcome of the treatment of this specific form of AML. The safety is investigated and how well it works. In order to properly assess the value of venetoclax, the effect of venetoclax is compared... Read More
The standard treatment for patients with acute myeloid leukemia (AML) with an abnormality in the IDH1 gene, who are not eligible for intensive chemotherapy, is a combination of ivosidenib and azacitidine. In this study it is investigated whether adding venetoclax to the standard treatment can improve the outcome of the treatment of this specific form of AML. The safety is investigated and how well it works. In order to properly assess the value of venetoclax, the effect of venetoclax is compared with the effect of a placebo. A placebo is a product without an active ingredient, a 'fake medicinal product'. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: AT-Feldkirch-IKHF, Feldkirch, Not set +118 locations
AT-Feldkirch-IKHF, Feldkirch, Not set
AT-Salzburg-SALK, Salzburg, Not set
AT-Vienna-HANUSCH, Vienna, Not set
BE-Antwerpen-ZAS, Antwerpen, Not set
BE-Brussel-BORDET, Brussel, Not set
BE-Brussel-UZBRUSSEL, Brussel, Not set
BE-Bruxelles-STLUC, Bruxelles, Not set
BE-Gent-UZGENT, Gent, Not set
BE-Leuven-UZLEUVEN, Leuven, Not set
BE-Liege-CHULIEGE, Liege, Not set
BE-Yvoir-MONTGODINNE, Yvoir, Not set
DK-Aalborg-AALBORGUH, Aalborg, Not set
DK-Aarhus N-AUH, Aarhus N, Not set
DK-Copenhagen-RIGSHOSPITALET, Copenhagen, Not set
DK-Odense-OUH, Odense, Not set
DK-Roskilde-ROSKILDE, Roskilde, Not set
EE-Tallinn-REGIONAALHAIGLA, Tallinn, Not set
EE-Tartu-TARTU, Tartu, Not set
FI-Helsinki-HUS, Helsinki, Not set
FI-Tampere-TAYS, Tampere, Not set
FR-Angers-CHUANGERS, Angers, Not set
FR-Pessac Cedex-CHUBORDEAUX, Bordeaux, Not set
FR-Caen-CHUCAEN, Caen, Not set
FR-Créteil cedex-CHUMONDOR, Créteil, Not set
FR-Grenoble cedex 9-CHUGRENOBLE, Grenoble, Not set
FR-Lille-CHULILLE, Lille, Not set
FR-Lyon Pierre Benite cedex-LYONSUD, Lyon, Not set
FR-Montpellier-CHUSAINTELOIS, Montpellier, Not set
FR-Nantes-CHUNANTES, Nantes, Not set
FR-Nice-LARCHET, Nice, Not set
FR-Rennes cedex 9-CHURENNES, Rennes, Not set
FR-Rouen cedex-BECQUEREL, Rouen, Not set
FR-Saint-Priest-en-Jarez-STETIENNE, St Etienne, Not set
FR-Le Chesnay cedex-CHVERSAILLES, Versailles, Not set
DE-Berlin-CAMPUSBENFRANKLIN, Berlin, Not set
DE-Berlin-CAMPUSVIRCHOW, Berlin, Not set
DE-Berlin-VIVANTESNEUKOLLN, Berlin, Not set
DE-Bochum-RUB, Bochum, Not set
DE-Bonn-UNIBONN, Bonn, Not set
DE-Braunschweig-KLINIKUMBRAUNSCHWEIG, Braunschweig, Not set
DE-Bremen-KBM, Bremen, Not set
DE-Darmstadt-KLINIKUMDARMSTADT, Darmstadt, Not set
DE-Flensburg-MALTESER, Flensburg, Not set
DE-Freiburg-UNIKLINIKFREIBURG, Freiburg, Not set
DE-Greifswald-UNIGREIFSWALD, Greifswald, Not set
DE-Halle-UMH, Halle, Not set
DE-Hamburg-ASKLEPIOSSTGEORG, Hamburg, Not set
DE-Hamburg-UKE, Hamburg, Not set
DE-Hannover-MHHANNOVER, Hannover, Not set
DE-Hannover-SILOAHKRH, Hannover, Not set
DE-Heilbronn-SLK, Heilbronn, Not set
DE-Karlsruhe-KLINIKUMKARLSRUHE, Karlsruhe, Not set
DE-Mainz-UNIMEDIZINMAINZ, Mainz, Not set
DE-Minden-MUEHLENKREISKLINKEN, Minden, Not set
DE-München-IRZTUM, München, Not set
DE-Oldenburg-KLINIKUMOLDENBURG, Oldenburg, Not set
DE-Regensburg-UKR, Regensburg, Not set
DE-Stuttgart-KLINIKUMSTUTTGART, Stuttgart, Not set
DE-Tübingen-MEDUNITUEBINGEN, Tübingen, Not set
DE-Ulm-UNIKLINKULM, Ulm, Not set
IE-Cork-CUH, Cork, Not set
IE-Dublin 7-MATER, Dublin 7, Not set
IE-Dublin 8-ST JAMES, Dublin 8, Not set
IE-Galway-UHGALWAY, Galway, Not set
IT-Bologna-MALPHIGI, Bologna, Not set
IT-Milano-NIGUARDA, Milano, Not set
IT-Roma-SAPIENZA, Roma, Not set
IT-Roma-TORVERGATA, Roma, Not set
IT-Torino-CITTADELLASALUTE, Torino, Not set
LT-Vilnius-SANTA, Vilnius, Not set
NL-Amsterdam-VUMC, Amsterdam, Not set
NL-Arnhem-RIJNSTATE, Arnhem, Not set
NL-Breda-AMPHIA, Breda, Not set
NL-Den Bosch-JBZ, Den Bosch, Not set
NL-DenHaag-HAGA, Den Haag, Not set
NL-Dordrecht-ASZ, Dordrecht, Not set
NL-Eindhoven-CATHARINA, Eindhoven, Not set
NL-Enschede-MST, Enschede, Not set
NL-Sittard-Geleen-ZUYDERLAND, Geleen, Not set
NL-Groningen-UMCG, Groningen, Not set
NL-Nijmegen-RADBOUDUMC, Nijmegen, Not set
NL-Rotterdam-ERASMUSMC, Rotterdam, Not set
NL-Utrecht-UMCU, Utrecht, Not set
NL-Zwolle-ISALA, Zwolle, Not set
NO-Bergen-HELSEBERGEN, Bergen, Not set
NO-Oslo-OSLOUH, Oslo, Not set
NO-Tromsø-NORTHNOORWEGEN, Tromso, Not set
NO-Trondheim-STOLAV, Trondheim, Not set
ES-Barcelona-CLINICUB, Barcelona, Not set
ES-Barcelona-GERMANTRIALS, Barcelona, Not set
ES-Barcelona-SANTPAU, Barcelona, Not set
ES-Girona-ICSTRUETA, Girona, Not set
ES-Valencia-MALVARROSA, Valencia, Not set
SE-Goteborg-SAHLGRENSKA, Goteborg, Not set
SE-Lund-SUH, Lund, Not set
SE-Stockholm-KAROLINSKAHUDDINGE, Stockholm, Not set
SE-Uppsala-UPPSALAUH, Uppsala, Not set
CH-Basel-USB, Basel, Not set
CH-Bellinzona-IOSI, Bellinzona, Not set
CH-Bern-INSEL, Bern, Not set
CH-Zurich-USZ, Zurich, Not set
UK-Birmingham-QE, Birmingham, Not set
UK-Blackpool-BLACKPOOLVICTORIA, Blackpool, Not set
UK-Bristol-BRISTOLCENTRE, Bristol, Not set
UK-Cardiff-UHW, Cardiff, Not set
UK-Glasgow-BEATSON, Glasgow, Not set
UK-Leeds-STJAMESUH, Leeds, Not set
UK-Leicester-LEICESTERRI, Leicester, Not set
UK-London-KCH, London, Not set
UK-London-ROYALMARSDEN, London, Not set
UK-London-UNICOLLEGEHOSP, London, Not set
UK-Manchester-CHRISTIE, Manchester, Not set
UK-Manchester-ROYALINFIRMARY, Manchester, Not set
UK-Newcastle on Tyne-FREEMAN, Newcastle upon Tyne, Not set
UK-Nottingham-NOTTINGHAMCH, Nottingham, Not set
UK-Oxford-CHURCHILL, Oxford, Not set
UK-Portsmouth-QUEENALEXANDRA, Portsmouth, Not set
UK-Southampton-SOUTHAMPTONGH, Southampton, Not set
UK-Wolverhampton-NEWCROSSH, Wolverhampton, Not set
Conditions: Acute Myeloid Leukemia
A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)
Recruiting
The primary objective of this study is to describe the long-term safety and tolerability of rocatinlimab in participants with moderate-to-severe AD.
The primary objective of this study is to describe the long-term safety and tolerability of rocatinlimab in participants with moderate-to-severe AD. Read Less
Gender:
ALL
Ages:
Between 12 years and 100 years
Trial Updated:
08/13/2025
Locations: Cahaba Dermatology and Skin Health Center, Birmingham, Alabama +543 locations
Cahaba Dermatology and Skin Health Center, Birmingham, Alabama
Medical Dermatology Specialists, Phoenix, Arizona
Alliance Dermatology and Mohs Center, Phoenix, Arizona
Affiliated Dermatology, Scottsdale, Arizona
Scottsdale Clinical Trials, Scottsdale, Arizona
Dermatology Trial Associates, Bryant, Arkansas
Burke Pharmaceutical Research, Hot Springs, Arkansas
Arkansas Research Trials, LLC, North Little Rock, Arkansas
Kern Research Inc, Bakersfield, California
Hope Clinical Research LLC, Canoga Park, California
West Coast Research LLC, Dublin, California
California Dermatology and Clinical Research Institute, Encinitas, California
First OC Dermatology, Fountain Valley, California
Antelope Valley Clinical Trials, Lancaster, California
Chemidox Clinical Trials Incorporated, Lancaster, California
Long Beach Research Institute, Long Beach, California
University of California Los Angeles, Los Angeles, California
Dermatology Research Associates, Los Angeles, California
Wallace Medical Group Inc, Los Angeles, California
Northridge Clinical Trials, Northridge, California
University of California Irvine, Orange, California
Havana Research Institute Inc, Pasadena, California
Integrative Skin Science and Research, Sacramento, California
University of California at Davis Medical Center, Sacramento, California
Kaiser Permanente South Sacramento Medical Center, Sacramento, California
Acclaim Clinical Research, San Diego, California
Kaiser Permanente Medical Center - Oakland, San Francisco, California
Kaiser Permanente Medical Center - San Francisco, San Francisco, California
Wolverine Clinical Trials, Santa Ana, California
Clinical Science Institute, Santa Monica, California
IMMUNOe Research Centers, Centennial, Colorado
Skin Care Research Incorporated, Boca Raton, Florida
Renaissance Research and Medical Group, Cape Coral, Florida
Driven Research LLC, Coral Gables, Florida
Corazon United States of America, LLC doing business as Life Clinical Trials, Coral Springs, Florida
D and H Doral Research Centers, Doral, Florida
Saint Jude Clinical Research, Doral, Florida
Direct Helpers Research Center, Hialeah, Florida
Global Research Solutions, Homestead, Florida
Nexus Clinical Research, Homestead, Florida
Glick Skin Institute, Margate, Florida
Meridian International Research, Miami Gardens, Florida
Savin Medical Group LLC, Miami Lakes, Florida
Gold Coast Health Research Center, Miami, Florida
Miami Clinical Research, Miami, Florida
Healthy Life Research, Miami, Florida
Anchor Medical Research, Miami, Florida
ara Professionals Limited Liability Corporation, Miami, Florida
Clinical Associates of Orlando Limited Liability Company, Orlando, Florida
Innovation Medical Research Center Inc, Palmetto Bay, Florida
University of South Florida, Tampa, Florida
Olympian Clinical Research - Tampa, Tampa, Florida
Atlanta Dermatology, Vein and Research Center, PC, Alpharetta, Georgia
First Georgia Physicians Group, Fayetteville, Georgia
Advanced Medical Research PC, Sandy Springs, Georgia
Treasure Valley Medical Research, Boise, Idaho
DeNova Research, Chicago, Illinois
Sneeze, Wheeze, and Itch Associates, LLC, Normal, Illinois
Endeavor Health Clinical Trials Center, Skokie, Illinois
Dundee Dermatology, West Dundee, Illinois
DS Research, Clarksville, Indiana
Dawes Fretzin Clinical Research Group, LLC, Indianapolis, Indiana
Southern Indiana Clinical Trials, New Albany, Indiana
The Indiana Clinical Trials Center PC, Plainfield, Indiana
Options Research Group LLC, West Lafayette, Indiana
Dermatology and Skin Cancer Center Leawood, Leawood, Kansas
DS Research, Louisville, Kentucky
Kentucky Advanced Medical Research LLC, Murray, Kentucky
Foxhall Research Center, Chevy Chase, Maryland
Institute for Asthma and Allergy, Chevy Chase, Maryland
Continental Clinical Solutions, LLC, Towson, Maryland
MetroBoston Clinical Partners, Brighton, Massachusetts
University of Michigan, Ann Arbor, Michigan
Henry Ford Medical Center - New Center One, Detroit, Michigan
Onyx Clinical Research, Flint, Michigan
Revival Research Institute LLC, Troy, Michigan
Somerset Skin Centre, Troy, Michigan
Dermatology and Skin Cancer Center of Lees Summit, Lee's Summit, Missouri
Saint Louis University, Saint Louis, Missouri
Somnos Clinical Research, Lincoln, Nebraska
Skin Specialists PC, Omaha, Nebraska
Jubilee Clinical Research Inc, Las Vegas, Nevada
Excel Clinical Research, Las Vegas, Nevada
Las Vegas Clinical Trials, North Las Vegas, Nevada
Skin Cancer and Dermatology Institute, Reno, Nevada
Albuquerque Clinical Trials Incorporated, Albuquerque, New Mexico
Chear Center LLC, Bronx, New York
Ace Clinical Trials, Brooklyn, New York
Forest Hills Dermatology Group, Kew Gardens, New York
Icahn School of Medicine at Mount Sinai, New York, New York
Sadick Research Group, New York, New York
OptiSkin Medical, New York, New York
DJL Clinical Research PLLC, Charlotte, North Carolina
Wilmington Dermatology Center, Wilmington, North Carolina
Accellacare of Wilmington, Wilmington, North Carolina
The Skin Surgery Center for Clinical Research, Winston-Salem, North Carolina
Bexley Dermatology Research, Bexley, Ohio
Bernstein Clinical Research Center LLC, Cincinnati, Ohio
The Ohio State University, Gahanna, Ohio
Apex Clinical Research Center LLC, Mayfield Heights, Ohio
Dermatologist of Central States Clinical Research - Springfield, Springfield, Ohio
Unity Clinical Research, Oklahoma City, Oklahoma
Dermatology Research Center of Oklahoma, PLLC, Tulsa, Oklahoma
Essential Medical Research LLC, Tulsa, Oklahoma
Velocity Clinical Research Medford, Medford, Oregon
Oregon Medical Research Center, Portland, Oregon
Oregon Dermatology and Research Center, Portland, Oregon
Best Skin Research, Camp Hill, Pennsylvania
Paddington Testing Company Inc, Philadelphia, Pennsylvania
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Health Concepts, Rapid City, South Dakota
Cumberland Skin Center, Hermitage, Tennessee
US Dermatology Partners Jollyville, Austin, Texas
Bellaire Dermatology Associates, Bellaire, Texas
US Dermatology Partners Cedar Park, Cedar Park, Texas
Driscoll Childrens Hospital, Corpus Christi, Texas
Alina Clinical Trials, LLC, Dallas, Texas
Dermatology Treatment and Research Center PA, Dallas, Texas
Zenos Clinical Research, Dallas, Texas
Texas Dermatology Research Center, Dallas, Texas
Newco 3A Research LLC, El Paso, Texas
Center For Clinical Studies PLLC, Houston, Texas
University of Texas Health Science Center at Houston, Houston, Texas
Sante Clinical Research, Kerrville, Texas
Long and Harris Dermatology, Lubbock, Texas
Sms Clinical Research Limited Liability Company, Mesquite, Texas
Stride Clinical Research LLC, Missouri City, Texas
Texas Dermatology and Laser Specialists, San Antonio, Texas
Dermatology Clinical Research Center of San Antonio, San Antonio, Texas
Stryde Research Epiphany Dermatology, Southlake, Texas
The Woodlands Dermatology Associates, The Woodlands, Texas
Tanner Clinic, Murray, Utah
University of Utah MidValley Dermatology, Murray, Utah
Education and Research Foundation Inc, Forest, Virginia
Virginia Dermatology and Skin Cancer Center, Norfolk, Virginia
Eastern Virginia Medical School, Norfolk, Virginia
MultiCare Institute for Research and Innovation, Spokane, Washington
Conexa Investigacion Clinica SA, Caba, Buenos Aires
Cinme - Centro de Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires, Buenos Aires
Fundacion Respirar, Ciudad Autonoma de Buenos Aires, Buenos Aires
Hospital Universitario Austral, Derqui, Pilar, Buenos Aires
Framingham Centro Medico, La Plata, Buenos Aires
InAER - Investigaciones en Alergia y Enfermedades Respiratorias, Caba, Distrito Federal
Buenos Aires Skin SA, Ciudad Autonoma de Buenos Aires, Distrito Federal
Fundacion Cidea, Ciudad Autonoma de Buenos Aires, Distrito Federal
Care- Centro de Alergia y Enfermedades Respiratorias, Ciudad Autonoma de Buenos Aires, Distrito Federal
Instituto de Neumonologia y Dermatologia, Ciudad Autonoma de Buenos Aires, Distrito Federal
Psoriahue Medicina Interdisciplinaria SRL, Ciudad Autonoma de Buenos Aires, Distrito Federal
Centro de Investigaciones Clinicas Instituto Especialidades De La Salud De Rosario, Rosario, Santa Fe
Fundacion Estudios Clinicos, Rosario, Santa Fe
Instituto de Diagnostico abc, Rosario, Santa Fe
Premier Specialists, Kogarah, New South Wales
St George Dermatology and Skin Cancer Centre, Kogarah, New South Wales
Liverpool Hospital, Liverpool, New South Wales
Royal North Shore Hospital, St Leonards, New South Wales
The Skin Centre, Benowa, Queensland
Princess Alexandra Hospital, South Brisbane, Queensland
Veracity Clinical Research, Woolloongabba, Queensland
Box Hill Hospital, Box Hill, Victoria
Emeritus Research Camberwell, Camberwell, Victoria
Skin Health Institute, Carlton, Victoria
Monash Childrens Hospital, Clayton, Victoria
The Alfred Hospital, Melbourne, Victoria
Institute for Skin Health and Immunity, Mitcham, Victoria
The Royal Melbourne Hospital, Parkville, Victoria
Medizinische Universitaet Graz, Graz, Not set
Landeskrankenhaus Salzburg, Salzburg, Not set
Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Bruxelles, Not set
Grand Hopital de Charleroi - Site des Viviers, Charleroi, Not set
Universitair Ziekenhuis Gent, Gent, Not set
Clinique Andre Renard, Herstal, Not set
Dermatologie Handelskaai, Kortrijk, Not set
Centre Hospitalier Universitaire de Liege - Sart Tilman, Liege, Not set
Dermatologie Maldegem, Maldegem, Not set
Clinica Instituto Bahiano de Imunoterapia - Medicina, Reumatologia e Dermatologia ltda, Salvador, Bahia
Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo, Vitoria, Espírito Santo
Ceti Centro Est Terap Inovadoras, Curitiba, Paraná
Universidade Federal do Parana, Curitiba, Paraná
Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande Do Sul
Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul
Hospital Ernesto Dornelles, Porto Alegre, Rio Grande Do Sul
Alergoalfa Nucleo Diagnostico Tratamento e Pesquisa Clinica em Alergia, Barueri, São Paulo
Cecip Centro Est Clin Int Paulista, Jau, São Paulo
Fundacao Abc - Centro Univ Fmabc, Santo Andre, São Paulo
Cemec Centro Multidisciplinar Estudos Clinicos, Sao Bernardo do Campo, São Paulo
Sociedade Beneficente de Senhoras Hospital Sirio Libanes, Sao Paulo, São Paulo
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, São Paulo
Consultoria Medica e Pesquisa Clinica Cmpc, Sorocaba, São Paulo
Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto, São Paulo
Ispem - Instituto Sao Jose dos Campos em Pesquisas Medicas, São José dos Campos, São Paulo
IBPClin Instituto Brasil de Pesquisa Clinica, Rio de Janeiro, Not set
Medical Center Asklepii OOD, Dupnitsa, Not set
Medical Center Medconsult Pleven OOD, Pleven, Not set
Medical Center Excelsior OOD, Sofia, Not set
Diagnostic-Consultative Center Alexandrovska EOOD, Sofia, Not set
Diagnostic-Consultative Center - Fokus-5 - Medical Institution for Outpatient Care OOD, Sofia, Not set
Dermatology Research Institute Incorporated, Calgary, Alberta
Beacon Dermatology, Calgary, Alberta
Laser Rejuvenation Clinics Edmonton D T Incorporated, Edmonton, Alberta
Stratica Dermatology, Edmonton, Alberta
Alberta Derma Surgery Centre, Edmonton, Alberta
Vida Clinical Research, Edmonton, Alberta
Skin Physicians Dermatology, Edmonton, Alberta
Interior Dermatology Centre, Kelowna, British Columbia
Doctor Chih-Ho Hong Medical Incorporated, Surrey, British Columbia
Enverus Medical Research, Surrey, British Columbia
Winnipeg Clinic Dermatology Research, Winnipeg, Manitoba
Wiseman Dermatology Research Incorporated, Winnipeg, Manitoba
Karma Clinical Trials, Saint John's, Newfoundland and Labrador
CCA Medical Research Corp, Ajax, Ontario
SimcoDerm Medical and Surgical Dermatology Centre, Barrie, Ontario
Halton Pediatric Allergy, Burlington, Ontario
SKiN Health, Coburg, Ontario
Kingsway Clinical Research, Etobicoke, Ontario
Guelph Dermatology Research, Guelph, Ontario
LEADER Research, Hamilton, Ontario
Triple A Lab, Hamilton, Ontario
Centricity Research London Victoria, London, Ontario
Lynderm Research Inc, Markham, Ontario
DermEdge Research Incorporated, Mississauga, Ontario
Ryan Clinical Research Incorporated, Newmarket, Ontario
Allergy Research Canada Incorporated, Niagara Falls, Ontario
North Bay Dermatology Centre, North Bay, Ontario
Canadian Dermatology Centre, North York, Ontario
The Centre for Clinical Trials Inc, Oakville, Ontario
JRB Research Incorporated, Ottawa, Ontario
Dermatology Ottawa Research Centre, Ottawa, Ontario
SKiN Centre for Dermatology, Peterborough, Ontario
The Centre for Dermatology, Richmond Hill, Ontario
York Dermatology Clinic and Research Centre, Richmond Hill, Ontario
Oak Ridges Aesthetics Centre, Richmond Hill, Ontario
North York Research Incorporated, Toronto, Ontario
Toronto Research Centre Inc, Toronto, Ontario
FACET Dermatology, Toronto, Ontario
Research Toronto, Toronto, Ontario
Evidence Based Medical Educator Inc, Toronto, Ontario
Alliance Clinical Trials, Waterloo, Ontario
XLR8 Medical Research, Incorporated, Windsor, Ontario
Clinique de Dermatologie Rosemont, Montreal, Quebec
Innovaderm Research Inc, Montreal, Quebec
Clinique Medicale Saint Louis, Quebec City, Quebec
Skinsense Medical Research, Saskatoon, Saskatchewan
Saskatoon Dermatology Centre, Saskatoon, Saskatchewan
Recherche Clinique Sigma Incorporated, Quebec, Not set
Centre de Recherche Dermatologique du Quebec Metropolitain, Quebec, Not set
Centro Dermatologico Dermisur, Osorno, Not set
Centro Medico Skinmed Spa, Santiago, Not set
Clinica Dermacross SA, Santiago, Not set
Centro Internacional de Estudios Clinicos, Santiago, Not set
Peking University Peoples Hospital, Beijing, Beijing
Beijing Childrens Hospital, Capital Medical University, Beijing, Beijing
Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing
Peking University Third Hospital, Beijing, Beijing
Childrens Hospital of Chongqing Medical University, Chongqing, Chongqing
The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian
The First Affiliated Hospital Sun-Yat Sen University, Guangzhou, Guangdong
Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong
Sun Yat-sen Memorial Hospital Sun Yat-sen University, Guangzhou, Guangdong
The Fist Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong
Shenzhen Childrens Hospital, Shenzhen, Guangdong
The First Hospital Of Hebei Medical University, Shijiazhuang, Hebei
Nanyang First Peoples Hospital, Nanyang, Henan
Sanmenxia Central Hospital, Sanmenxia, Henan
The Central Hospital of Wuhan, Wuhan, Hubei
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei
Hunan Childrens Hospital, Changsha, Hunan
The Second Xiangya Hospital of Central South University, Changsha, Hunan
Wuxi Second Peoples Hospital, Wuxi, Jiangsu
Wuxi Peoples Hospital, Wuxi, Jiangsu
Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi
The First Bethune Hospital of Jilin University, Changchun, Jilin
The First Hospital of China Medical University, Shenyang, Liaoning
General Hospital of Ningxia Medical University, Yinchuan, Ningxia
Shanghai Skin Disease Hospital, Shanghai, Shanghai
Chengdu Second Peoples Hospital, Chengdu, Sichuan
Suining Central Hospital, Suining, Sichuan
Kunming Childrens Hospital, Kunming, Yunnan
Zhejiang Provincial Peoples Hospital, Hangzhou, Zhejiang
Affiliated Hangzhou First Peoples Hospital School of Medicine Westlake University, Hangzhou, Zhejiang
Ningbo NO 2 Hospital, Ningbo, Zhejiang
The First Affiliation Hospital Of Ningbo University, Ningbo, Zhejiang
Taizhou Central Hospital, Taizhou, Zhejiang
Special Hospital for Medical Rehabilitation Naftalan, Ivanic-Grad, Not set
Children s Hospital Zagreb, Zagreb, Not set
University Hospital Centre Zagreb, Zagreb, Not set
Kozni ambulance Kutna Hora sro, Kutna Hora, Not set
Dermamedica, sro, Nachod, Not set
Nemocnice Novy Jicin as, Novy Jicin, Not set
CCR Ostrava sro, Ostrava, Not set
Pratia Pardubice as, Pardubice, Not set
Fakultni nemocnice Plzen, Plzen, Not set
Clintrial sro, Praha 10, Not set
Pratia Prague sro, Praha 3, Not set
Praglandia sro, Praha 5 - Smichov, Not set
Kozni ambulance Fialova sro, Praha 6, Not set
Fakultni nemocnice Bulovka, Praha 8, Not set
Dermamedest sro, Praha, Not set
Dermatologicka ambulance MUDr Petr Trestik, Svitavy, Not set
Krajska zdravotni as - Masarykova nemocnice Usti nad Labem oz, Usti nad Labem, Not set
Gentofte Hospital, Hellerup, Not set
North Estonia Medical Centre, Tallinn, Not set
Clinical Research Centre, Tartu, Not set
Clinical Research Services Helsinki, Helsinki, Not set
Oulun Yliopistollinen sairaala, Oulu, Not set
Terveystalo Tampere, Tampere, Not set
Hopital Prive d Antony, Antony, Not set
Polyclinique de Courlancy, Bezannes, Not set
Centre Hospitalier Regional Universitaire de Brest - Hopital Morvan, Brest, Not set
Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez, Lille, Not set
Centre Hospitalier de Bretagne Sud - Hopital du Scorff, Lorient Cedex, Not set
Cabinet du Docteur Ruer-Mulard Mireille, Martigues, Not set
Centre Hospitalier Universitaire Archet 2, Nice, Not set
Hopital Saint Louis, Paris Cedex 10, Not set
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes Cedex 9, Not set
Centre Hospitalier Universitaire de Rouen - Hopital Charles Nicolle, Rouen, Not set
Fachklinik Bad Bentheim, Bad Bentheim, Not set
Charite - Universitaetsmedizin Berlin, Campus Mitte, Berlin, Not set
Clinical Research Services Berlin GmbH, Berlin, Not set
Hautarztpraxis Dr Niesmann und Dr Othlinghaus, Bochum, Not set
Rosenpark Research GmbH, Darmstadt, Not set
Universitaetsklinikum Dresden, Dresden, Not set
Universitaetsklinikum Frankfurt, Frankfurt am Main, Not set
Universitaetsmedizin Goettingen - Georg-August-Universitaet, Goettingen, Not set
Institute for Health Services Research in Dermatology and Nursing, Hamburg, Not set
Hautaerzte Zentrum Hannover, Hannover, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Universitaetsklinikum Schleswig-Holstein, Kiel, Not set
Velocity Clinical Research, Leipzig, Not set
Dermatologische Gemeinschaftspraxis-Mahlow, Mahlow, Not set
Universitaetsmedizin Mainz, Mainz, Not set
Beldio Research GmbH, Memmingen, Not set
Hautmedizin Saar, Merzing, Not set
Klinikum rechts der Isar der TUM, Muenchen, Not set
Universitaetsklinikum Muenster, Muenster, Not set
KliFOs Klinische Forschung Osnabrueck, Osnabrueck, Not set
Hautarztpraxis Mortazawi, Remscheid, Not set
Hautarztpraxis Dres Leitz und Kollegen, Stuttgart, Not set
Universitaetsklinikum Tuebingen, Tuebingen, Not set
Helios Klinikum Wuppertal, Wuppertal, Not set
CentroDerm GmbH, Wuppertal, Not set
University General Hospital Attikon, Athens, Not set
Andreas Syngros Hospital Of Venereal And Dermatological Diseases, Athens, Not set
University General Hospital of Ioannina, Ioannina, Not set
General University Hospital of Larissa, Larissa, Not set
General Hospital Of Nea Ionia Konstantopouleio Patision, Nea Ionia, Not set
Geniko Nosokomeio Peiraia Tzaneio, Piraeus, Not set
Papageorgiou General Hospital, Thessaloniki, Not set
Queen Mary Hospital, The University of Hong Kong, Hong Kong, Not set
Trial Pharma Kft, Bekescsaba, Not set
Csalogany Orvosi Kozpont, Budapest, Not set
Clinexpert Kft, Budapest, Not set
Obudai Egeszsegugyi Centrum Kft, Budapest, Not set
Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set
Gyongyosi Bugat Pal Korhaz, Gyongyos, Not set
Somogy Varmegyei Kaposi Mor Oktato Korhaz, Kaposvar, Not set
DermaMed Research Kft, Oroshaza, Not set
Allergo-Derm Bakos Kft, Szolnok, Not set
Medmare Bt, Veszprem, Not set
Obudai Egeszsegugyi Centrum Kft, Zalaegerszeg, Not set
Sheba Medical Center, Ramat Gan, Not set
Universita degli Studi Gabriele D Annunzio di Chieti e Pescara, Chieti, Not set
Ospedale San Salvatore, LAquila, Not set
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Not set
Azienda Ospedaliera Universitaria Luigi Vanvitelli, Napoli, Not set
Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia, Perugia, Not set
Azienda Ospedaliera Policlinico Umberto I, Roma, Not set
IRCCS Istituto Clinico Humanitas, Rozzano MI, Not set
Azienda Ospedaliera Citta della Salute e della Scienza di Torino, Torino, Not set
Aichi Medical University Hospital, Nagakute-shi, Aichi
Fukui Dermatology Clinic, Nagoya-shi, Aichi
Japan Community Healthcare Organization Chukyo Hospital, Nagoya-shi, Aichi
Central Clinic, Nagoya-shi, Aichi
Nagoya City University Hospital, Nagoya-shi, Aichi
Miyata Dermatology Clinic, Matsudo-shi, Chiba
International University of Health and Welfare Narita Hospital, Narita-shi, Chiba
Ekihigashi Dermatology Allergy Clinic, Fukuoka-shi, Fukuoka
Fukuoka University Hospital, Fukuoka-shi, Fukuoka
Matsuo Clinic, Fukuoka-shi, Fukuoka
Fukushima Medical University Hospital, Fukushima-shi, Fukushima
Asahikawa City Hospital, Asahikawa-shi, Hokkaido
Takagi Dermatological Clinic, Obihiro-shi, Hokkaido
Medical Corporation Kojinkai Sapporo Skin Clinic, Sapporo-shi, Hokkaido
Yoshimura Child Clinic, Akashi-shi, Hyogo
Kobe University Hospital, Kobe-shi, Hyogo
Tokyo Medical University Ibaraki Medical Center, Inashiki-gun, Ibaraki
Kaji Dermatology Clinic, Nonoichi-shi, Ishikawa
Iwate Medical University Uchimaru Medical Center, Morioka-shi, Iwate
Takeoka Dermatology Clinic, Marugame-shi, Kagawa
Katahira Dermatology Urology Clinic, Kagoshima-shi, Kagoshima
Kosugi Dermatology Clinic, Kawasaki-shi, Kanagawa
Nippon Medical School Musashikosugi Hospital, Kawasaki-shi, Kanagawa
St Marianna University Hospital, Kawasaki-shi, Kanagawa
National Hospital Organization Sagamihara National Hospital, Sagamihara-shi, Kanagawa
Nomura Dermatology Clinic, Yokohama-shi, Kanagawa
Showa Medical University Northern Yokohama Hospital, Yokohama-shi, Kanagawa
Yokohama City Minato Red Cross Hospital, Yokohama-shi, Kanagawa
Jouzan Hihuka Hinyoukika Clinic, Kumamoto-shi, Kumamoto
Suizenji Dermatology Clinic, Kumamoto-shi, Kumamoto
University Hospital Kyoto Prefectural University of Medicine, Kyoto-shi, Kyoto
Rakuwakai Otowa Hospital, Kyoto-shi, Kyoto
Nagasaki University Hospital, Nagasaki-shi, Nagasaki
Osaka Habikino Medical Center, Habikino-shi, Osaka
Mochida Dermatology Clinic, Izumiotsu-shi, Osaka
Yoshioka Dermatology Clinic, Neyagawa-shi, Osaka
Dermatology and Ophthalmology Kume Clinic, Sakai-shi, Osaka
JA Shizuoka Kohseiren Enshu Hospital, Hamamatsu-shi, Shizuoka
Hamamatsu University Hospital, Hamamatsu-shi, Shizuoka
Dokkyo Medical University Hospital, Shimotsuga-gun, Tochigi
Mildix Skin Clinic, Adachi-ku, Tokyo
Teikyo University Hospital, Itabashi-ku, Tokyo
Nihon University Itabashi Hospital, Itabashi-ku, Tokyo
Mita Dermatology Clinic, Minato-ku, Tokyo
Naoko Dermatology Clinic, Setagaya-ku, Tokyo
NTT Medical Center Tokyo, Shinagawa-ku, Tokyo
Showa Medical University Hospital, Shinagawa-ku, Tokyo
Seibo International Catholic Hospital, Shinjuku-ku, Tokyo
Yamate Dermatology Clinic, Shinjuku-ku, Tokyo
Sugamo Kobayashi Derma Clinic, Toshima-ku, Tokyo
Shirasaki Dermatology Clinic, Takaoka-shi, Toyama
Korea University Ansan Hospital, Ansansi, Gyeonggido, Not set
SoonChunHyang University Hospital Bucheon, Bucheon-si, Gyeonggi-do, Not set
Chosun University Hospital, Gwangju, Not set
The Catholic University of Korea Incheon St Marys Hospital, Incheon, Not set
Inha University Hospital, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
National Medical Center, Seoul, Not set
Konkuk University Medical Center, Seoul, Not set
Kyung Hee University Hospital at Gangdong, Seoul, Not set
Asan Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Marys Hospital, Seoul, Not set
Chung-Ang University Hospital, Seoul, Not set
Hallym University Kangnam Sacred Heart Hospital, Seoul, Not set
Ewha Womans University Seoul Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Ajou University Hospital, Suwon-si, Gyeonggi-do, Not set
Outpatient clinic Veselibas Centrs 4, Riga, Not set
Outpatient clinic Veselibascentrs 4, Riga, Not set
Smite Aija practice in dermatology and venerology, Talsi, Not set
Hospital Sultan Ismail, Johor Bahru, Johor
Hospital Raja Permaisuri Bainun, Ipoh, Perak
Hospital Pulau Pinang, Georgetown, Pinang
University Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan
Clínica de Enfermedades Crónicas y de Procedimientos Especiales, Morelia, Michoacán
Phylasis Clinical Research, Cuautitlán Izcalli, Not set
Bravis Ziekenhuis, Bergen op Zoom, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Universitair Medisch Centrum Utrecht, Utrecht, Not set
ClinicMed Daniluk Nowak Spolka komandytowa, Bialystok, Not set
Dermapolis Medical Dermatology Center dr n med Edyta Gebska, Chorzow, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
AKK Medical Spolka z ograniczona odpowiedzialnoscia Centrum Medyczne Tu sie leczy, Gdansk, Not set
GynCentrum Spzoo NZOZ Holsamed - Oddzial Libero, Katowice, Not set
Centrum Medyczne Angelius Provita, Katowice, Not set
Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski Pawel Brzewski SpCywilna, Krakow, Not set
Diamond Clinic Spolka z Ograniczona Odpowiedzialnoscia Diamond Medical Center, Krakow, Not set
Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna, Lodz, Not set
AppleTreeClinics Network Spzoo, Lodz, Not set
Ip Clinic Sp zoo, Lodz, Not set
Amicare Spolka z ograniczona odpowiedzialnoscia Spolka Komandytowa Amicare Centrum Medyczne, Lodz, Not set
Clinical Best Solutions Sp zoo Spolka Komandytowa, Lublin, Not set
Centrum Zdrowia i Urody Maxxmed, Lublin, Not set
Centrum Badawcze Panaceum Agnieszka Brzezicka Magdalena Lenkiewicz Spzoo, Malbork, Not set
Twoja przychodnia Ncm, Nowa Sol, Not set
Twoja przychodnia Pcm, Poznan, Not set
Centrum Zdrowia Dziecka i Rodziny Im Jana Pawla II w Sosnowcu Osrodek Badan Klinicznych, Sosnowiec, Not set
Twoja Przychodnia Scm, Szczecin, Not set
Alergo-Med Osrodek Badan Klinicznych sp zoo, Tarnow, Not set
Klinika Osipowicz and Turkowski Sp zoo, Warszawa, Not set
High Med Przychodnia Specjalistyczna, Warszawa, Not set
Evimed sp zoo centrum medyczne evimed, Warszawa, Not set
Klinika Ambroziak Dermatologia, Warszawa, Not set
Royalderm Agnieszka Nawrocka, Warszawa, Not set
Dermaceum Spolka z Ograniczona Odpowiedzialnoscia Dermaceum Centrum Medyczne, Wroclaw, Not set
DermMedica Spzoo Centrum Columbus, Wroclaw, Not set
Unidade de Saude Local de Almada-Seixal, EPE - Hospital Garcia de Orta, Almada, Not set
Unidade Local de Saude de Coimbra, EPE, Coimbra, Not set
Hospital Cuf Descobertas, Lisboa, Not set
Unidade Local de Saude de Santo Antonio, EPE - Hospital de Santo Antonio, Porto, Not set
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao, Porto, Not set
Derma Cluj, Cluj-Napoca, Not set
National University Hospital, Singapore, Not set
Singapore General Hospital, Singapore, Not set
National Skin Centre, Singapore, Not set
Fakultna Nemocnica s poliklinikou F D Roosevelta Banska Bystrica, Banska Bystrica, Not set
Maxderm, sro, Bardejov, Not set
Univerzitna nemocnica Bratislava - Nemocnica Stare Mesto, Bratislava, Not set
Derma therapy, spol s ro, Bratislava, Not set
Sanare spol sro, Svidnik, Not set
Kaderma Majtan, sro, Topolcany, Not set
Univerzitetni klinicni center Ljubljana, Ljubljana, Not set
Univerzitetni Klinicni Center Maribor, Maribor, Not set
Hiway Medical Centre, Westville, Durban, KwaZulu-Natal
Hospital Universitario Reina Sofia, Cordoba, Andalucía
Hospital Universitario Virgen Macarena, Sevilla, Andalucía
Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Canarias
Hospital Universitari Germans Trias i Pujol, Badalona, Cataluña
Hospital de la Santa Creu i Sant Pau, Barcelona, Cataluña
Hospital Universitari de Bellvitge, Hospitalet de LLobregat, Cataluña
Hospital General Universitario de Alicante, Alicante, Comunidad Valenciana
Hospital de Manises, Manises, Comunidad Valenciana
Hospital Arnau de Vilanova de Valencia, Valencia, Comunidad Valenciana
Hospital Clinico Universitario de Santiago, Santiago de Compostela, Galicia
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Madrid
Clinica Universidad de Navarra, Pamplona, Navarra
Hospital Universitario Basurto, Bilbao, País Vasco
Hospital Universitario de La Princesa, Madrid, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Hospital Universitario Infanta Leonor, Madrid, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Inselspital Bern, Bern, Not set
Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
Universitaetsspital Zuerich, Zuerich, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Mackay Memorial Hospital Taipei Branch, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital, Taoyuan, Not set
King Chulalongkorn Memorial Hospital, Bangkok, Not set
Siriraj Hospital, Bangkok, Not set
Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Not set
Thammasat University Hospital, Pathum Thani, Not set
Ankara Bilkent Sehir Hastanesi, Ankara, Not set
Gaziantep Universitesi Tip Fakultesi Hastanesi, Gaziantep, Not set
Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi, Istanbul, Not set
Acibadem Altunizade Hastanesi, Istanbul, Not set
Marmara Universitesi Tip Fakultesi Hastanesi, Istanbul, Not set
Bakircay Universitesi Cigli Egitim ve Arastirma Hastanesi, Izmir, Not set
Erciyes Universitesi Tip Fakultesi Hastanesi, Kayseri, Not set
Kocaeli Universitesi Tip Fakultesi Hastanesi, Kocaeli, Not set
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi, Samsun, Not set
Alder Hey Childrens Hospital, Liverpool, Not set
Whipps Cross University Hospital, London, Not set
The Royal Free Hospital, London, Not set
Guys Hospital, London, Not set
Salford Care Organisation, Salford, Not set
Accellacare Yorkshire, Shipley, Not set
Conditions: Atopic Dermatitis
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Recruiting
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxaliplatin (mFOLFOX6) or 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus cetuximab and mFOLFOX6 or FOLFIRI in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS)/ Neuroblastoma R... Read More
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxaliplatin (mFOLFOX6) or 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus cetuximab and mFOLFOX6 or FOLFIRI in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS)/ Neuroblastoma RAS viral oncogene homolog (NRAS) and v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) wild type (WT) unresectable or metastatic left-sided colorectal cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +221 locations
Banner MD Anderson Cancer Center, Gilbert, Arizona
St. Bernard's Medical Center, Jonesboro, Arkansas
CBCC Global Research, Bakersfield, California
Los Angeles Cancer Network, Glendale, California
Cancer and Blood Specialty Clinic, Los Alamitos, California
USC Norris Comprehensive Cancer Center, Los Angeles, California
UCLA, Santa Monica, California
Providence Medical Foundation, Santa Rosa, California
Torrance Memorial Physicians Network, Torrance, California
Rocky Mountain Cancer Centers, Denver, Colorado
Yale University School Of Medicine, New Haven, Connecticut
Georgetown Univ Medical Center Lombardi Cancer Center, Washington, District of Columbia
Florida Cancer Specialists South, Fort Myers, Florida
AdventHealth Medical Group Oncology and Hematology at Orlando, Orlando, Florida
Florida Cancer Specialists North Region, Saint Petersburg, Florida
Florida Cancer Specialists East, West Palm Beach, Florida
Grady Memorial Hospital, Atlanta, Georgia
Winship Cancer Institute Emory University, Atlanta, Georgia
Fort Wayne Medical Oncology & Hematology, Fort Wayne, Indiana
Ochsner Clinic Foundation, New Orleans, Louisiana
MedStar Franklin Square Medical Center, Baltimore, Maryland
VA Ann Arbor Healthcare System, Ann Arbor, Michigan
University of Michigan, Ann Arbor, Michigan
Henry Ford Hospital, Detroit, Michigan
Hattiesburg Clinic, Hattiesburg, Mississippi
Washington University School Of Medicine, Saint Louis, Missouri
Nebraska Cancer Specialists Midwest Cancer Center, Omaha, Nebraska
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Astera Cancer Care, East Brunswick, New Jersey
Rutgers Cancer Institute, New Brunswick, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Montefiore Einstein Comprehensive Cancer Center, Bronx, New York
Perlmutter Cancer Center at NYU Long Island, Mineola, New York
Mount Sinai, New York, New York
Mount Sinai West, New York, New York
NYU Langone Medical Center NYU Hematology Associates, New York, New York
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York, New York
New York Cancer and Blood Specialists, Shirley, New York
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center Fairview Hospital Moll Pavilion, Cleveland, Ohio
Taussig Cancer Insititute Cleveland Clinic, Cleveland, Ohio
Cleveland Clinic Cancer Center Independence Family Health Center, Independence, Ohio
Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio
Cleveland Clinic Cancer Center Hillcrest Hospital, Mayfield Heights, Ohio
Cleveland Clinic Cancer Centers Sandusky, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
Cleveland Clinic Cancer Center South Pointe Hospital, Warrensville Heights, Ohio
Wooster Milltown Specialty and Surgery Center, Wooster, Ohio
Thomas Jefferson University, Philadelphia, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
SCRI Oncology Partners, Nashville, Tennessee
Texas Oncology West Texas, Abilene, Texas
Texas Oncology DFW, Dallas, Texas
MD Anderson Cancer Center, Houston, Texas
Texas Oncology - San Antonio, San Antonio, Texas
Baylor Scott and White Health, Temple, Texas
Virginia Cancer Specialists, Arlington, Virginia
Inova Schar Cancer Institute Dept of Fairfax Hospital, Fairfax, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Swedish Cancer Institute, Edmonds, Washington
Swedish Cancer Institute, Issaquah, Washington
Swedish Cancer Institute, Seattle, Washington
William S. Middleton Memorial VA, Madison, Wisconsin
Institut Jules Bordet, Anderlecht, Not set
Universitair Ziekenhuis Antwerpen, Edegem, Not set
AZ Maria Middelares, Gent, Not set
Hopital de Jolimont, Haine Saint Paul La Louviere, Not set
Az Groeninge, Kortrijk, Not set
Universitair Ziekenhuis Leuven, Leuven, Not set
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman, Liege, Not set
Fundacao Pio XII, Barretos, Not set
Fundacao Universidade de Caxias do Sul, Caxias do Sul, Not set
Fundacao Doutor Amaral Carvalho, Jau, Not set
Hospital Nossa Senhora da Conceicao S A, Porto Alegre, Not set
Hospital Santa Izabel Santa Casa de Misericordia da Bahia, Salvador, Not set
Clinica de Hematologia e Oncologia Viver Ltda, Santa Maria, Not set
Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base, Sao Jose do Rio Preto, Not set
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Not set
Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, Not set
Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia, Vitoria, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Ottawa Hospital, Ottawa, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Centre de Recherche du CHUM, Montreal, Quebec
Peking University First Hospital, Beijing, Not set
Beijing Friendship Hospital Capital Medical University, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
Peking University Third Hospital, Beijing, Not set
The First Bethune Hospital of Jilin University, Changchun, Not set
Hunan Cancer hospital, Changsha, Not set
Sun Yat Sen University Cancer Center, Guangzhou, Not set
The Sixth Affiliated Hospital Sun Yat sen University, Guangzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The First Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Not set
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin medical university cancer hospital, Harbin, Not set
Huizhou Central People's Hospital, Huizhou, Not set
The First Affiliated Hospital of NanChang University, Nanchang, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Liaoning Cancer Hospital and Institute, Shenyang, Not set
Peking University Shenzhen Hospital, Shenzhen, Not set
West China Hospital of Sichuan University, Sichuan, Not set
First Hospital of Shanxi Medical University, Taiyuan, Not set
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Not set
Hubei Cancer Hospital, Wuhan, Not set
Institut Sainte Catherine, Avignon Cedex 9, Not set
Hopital Claude Huriez, Lille, Not set
Hopital Prive Jean Mermoz, Lyon, Not set
Institut du Cancer de Montpellier, Montpellier, Not set
CHU Nantes, Nantes Cedex 1, Not set
Hopital Saint Antoine, Paris, Not set
Hopital Haut Leveque, Pessac, Not set
CHU De Poitiers, Poitiers Cedex, Not set
Gustave Roussy, Villejuif, Not set
Charite Universitatsmedizin Berlin Campus Virchow Klinikum, Berlin, Not set
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden, Not set
Essen University Hospital, Essen, Not set
Krankenhaus NorthWest, Frankfurt am Main, Not set
Praxis fur interdisziplinare Onkologie & Hamatologie GbR, Freiburg, Not set
Asklepios Klinik Altona, Hamburg, Not set
National Center for Tumor Diseases NCT, Heidelberg, Not set
Universitatsmedizin der Johannes Gutenberg Universitat Mainz, Mainz, Not set
Klinikum der Universitaet Muenchen, Munich, Not set
Universitatsklinikum Ulm, Ulm, Not set
Semmelweis Egyetem, Budapest, Not set
Markhot Ferenc Oktatokorhaz es Rendelointezet, Eger, Not set
Pecsi Tudomanyegyetem, Pecs, Not set
Szegedi Tudomanyegyetem, Szeged, Not set
Rajiv Gandhi Cancer Institute and Research Centre, Delhi, Not set
B P Poddar Hospital and Medical research Limited, Kolkata, Not set
Tata Memorial Hospital, Mumbai, Not set
Deenanath Mangeshkar Hospital and Research Centre, Pune, Not set
Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, Not set
Yitzhak Shamir Medical Center, Beer Yaakov, Not set
Rambam Medical Center, Haifa, Not set
Hadassah University Hospita Ein Kerem, Jerusalem, Not set
Rabin Medical Center, Petah Tikva, Not set
Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv Yafo, Not set
Assuta MC, Tel Aviv Yafo, Not set
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Not set
Istituto Dei Tumori Di Milano, Milano, Not set
Istituto Oncologico Veneto - IRCCS, Padova, Not set
Azienda Ospedaliero Universitaria Pisana, Pisa, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Chiba Cancer Center, Chiba, Not set
National Cancer Center Hospital, Chuo Ku, Not set
National Cancer Center Hospital East, Kashiwa, Not set
Aichi Cancer Center, Nagoya Shi, Not set
Osaka International Cancer Institute, Osaka City, Not set
National Hospital Organization Osaka National Hospital, Osaka-Shi, Not set
Shizuoka Cancer Center, Shizuoka, Not set
The University of Osaka Hospital, Suita City, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Marys Hospital, Seoul, Not set
Hospital Canselor Tuanku Muhriz UKM, Cheras, Not set
Hospital Pulau Pinang, Georgetown, Not set
Hospital Raja Permaisuri Bainun, Ipoh, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Hospital Umum Sarawak, Kuching, Not set
National Cancer Institute, Putrajaya, Not set
Meander Medisch Centrum, Amersfoort, Not set
Antoni van Leeuwenhoek, Amsterdam, Not set
Radboud University Medical Center, Nijmegen, Not set
Erasmus MC, Rotterdam, Not set
Elisabeth-TweeSteden Ziekenhuis, Tilburg, Not set
UMC Utrecht, Utrecht, Not set
Wojewodzki Szpital Specjalistyczny, Biala Podlaska, Not set
Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku, Bialystok, Not set
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozow, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach, Gliwice, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie, Olsztyn, Not set
SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego, Opole, Not set
Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie, Warszawa, Not set
Pan American Center for Oncology Trials LLC, Barrio Monacillos, Not set
Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set
Hosp. Univ. Ramon Y Cajal, Madrid, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Clinica Univ. de Navarra, Pamplona, Not set
Hosp. Virgen Del Rocio, Sevilla, Not set
Hosp. Clinico Univ. de Valencia, Valencia, Not set
Sahlgrenska University Hospital, Goteborg, Not set
Skanes universitetssjukhus, Lund, Not set
Sodersjukhuset, Stockholm, Not set
Karolinska Universitetssjukhuset, Stockholm, Not set
Uppsala University, Uppsala, Not set
Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital, Taoyuan, Not set
Adana City Hospital, Adana, Not set
Gulhane Egitim ve Arastirma Hastanesi, Ankara, Not set
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Not set
Gazi University Hospital, Ankara, Not set
Ankara Bilkent Sehir Hastanesi, Ankara, Not set
Bakirkoy Training and Research Hospital, Istanbul, Not set
Marmara University Pendik Training Hospital, İstanbul, Not set
Necmettin Erbakan University Meram Medical Faculty, Konya, Not set
Sakarya University Training and Research Hospital, Sakarya, Not set
Birmingham Heartlands Hospital, Birmingham, Not set
Addenbrooke's Hospital, Cambridge, Not set
Western General Hospital, Edinburgh, Not set
Castle Hill Hospital, Hull, Not set
St James University Hospital, Leeds, Not set
St Bartholomew's Hospital, London, Not set
University College Hospital, London, Not set
Mount Vernon Cancer Centre, Northwood, Not set
Royal Marsden Hospital (Sutton), Sutton, Not set
Conditions: Colorectal Neoplasms
A Clinical Study of PGN-EDODM1 in People With Myotonic Dystrophy Type 1
Recruiting
The purpose of this study is to learn about the effects of an investigational medicine, PGN-EDODM1, to see how safe and tolerable multiple administrations of PGN-EDODM1 are for people with myotonic dystrophy type 1 (DM1) compared to placebo.
The purpose of this study is to learn about the effects of an investigational medicine, PGN-EDODM1, to see how safe and tolerable multiple administrations of PGN-EDODM1 are for people with myotonic dystrophy type 1 (DM1) compared to placebo. Read Less
Gender:
ALL
Ages:
Between 16 years and 60 years
Trial Updated:
08/13/2025
Locations: University of Calgary, Calgary, Alberta +5 locations
University of Calgary, Calgary, Alberta
Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario
CIUSSS du Saguenay-Lac-Saint-Jean, Chicoutimi, Quebec
Montreal Neurological Institute, Montréal, Quebec
University College London Hospitals NHS Foundation Trust, London, UK
Newcastle Upon Tyne Hospitals, Newcastle Upon Tyne, Not set
Conditions: Myotonic Dystrophy 1
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Recruiting
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of divarasib combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC).
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of divarasib combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: City of Hope National Medical Center, Duarte, California +65 locations
City of Hope National Medical Center, Duarte, California
City of Hope - Seacliff, Huntington Beach, California
City of Hope at Irvine Lennar, Irvine, California
UCSD Moores Cancer Center, La Jolla, California
Yale Cancer Center, New Haven, Connecticut
NYU Langone Hospital - Long Island, Mineola, New York
NYU Cancer Center, New York, New York
Mount SInai Medical Center, New York, New York
MD Anderson Cancer Center, Houston, Texas
Oncology & Hematology Associates of Southwest Virginia, Inc, Blacksburg, Virginia
Virginia Oncology Associates, Norfolk, Virginia
Hospital Britanico, Buenos Aires, Not set
Clinica Adventista Belgrano, Ciudad Autonoma Buenos Aires, Not set
Centro Oncologico Riojano Integral (CORI), La Rioja, Not set
Concord Repatriation General Hospital, Concord, New South Wales
Peter MacCallum Cancer Centre, Melbourne, Victoria
Alfred Health, Melbourne, Victoria
Cliniques Universitaires St-Luc, Bruxelles, Not set
Jessa Zkh (Campus Virga Jesse), Hasselt, Not set
Clinique Ste-Elisabeth, Namur, Not set
AZ Delta (Campus Rumbeke), Roeselare, Not set
Hospital de Cancer de Barretos, Barretos, São Paulo
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, São Paulo
Ottawa Hospital Regional Cancer Centre, Ottawa, Ontario
Princess Margaret Cancer Center, Toronto, Ontario
Jewish General Hospital, Montreal, Quebec
Hunan Cancer Hospital, Changsha CITY, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Shanghai Pulmonary Hospital, Shanghai, Not set
Rambam Medical Center, Haifa, Not set
Rabin MC, Petach Tikva, Not set
Tel Aviv Sourasky Medical Ctr, Tel Aviv, Not set
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Campania
Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio
Irccs Istituto Nazionale Dei Tumori (Int), Milano, Lombardia
A.O. Universitaria S. Luigi Gonzaga, Orbassano, Piemonte
National Cancer Center Hospital East, Chiba, Not set
Kindai University Hospital, Osaka, Not set
National Cancer Center Hospital, Tokyo, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Pusan National University Hospital, Busan, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
NKI The Netherlands Cancer Institute, Amsterdam, Not set
UMC St Radboud, Nijmegen, Not set
Uniwersyteckie Centrum Kliniczne, Gda?sk, Not set
Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II, Kraków, Not set
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie, Olsztyn, Not set
ICO Badalona-H.U. Germans Trias i Pujol, Badalona, Barcelona
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Sahlgrenska University Hospital, Göteborg, Not set
Universitätsspital Basel, Basel, Not set
Inselspital Bern, Bern, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan Uni Hospital, Taipei, Not set
Chang Gung Medical Foundation - Linkou, Taoyuan, Not set
Beatson West of Scotland Cancer Centre, Glasgow, Not set
Barts & London School of Med, London, Not set
Conditions: Non-Small Cell Lung Cancer
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-positive Cancers.
Recruiting
This clinical trial is looking at a drug called entrectinib. Entrectinib is approved as standard of care treatment for adult patients with non-small cell lung cancer (NSCLC) which have a particular molecular alteration called ROS1-positive, and patients 12 years old or above with solid tumours which have another type of change in the cancer cells. This means it has gone through clinical trials and been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK.
Investi... Read More
This clinical trial is looking at a drug called entrectinib. Entrectinib is approved as standard of care treatment for adult patients with non-small cell lung cancer (NSCLC) which have a particular molecular alteration called ROS1-positive, and patients 12 years old or above with solid tumours which have another type of change in the cancer cells. This means it has gone through clinical trials and been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK.
Investigators now wish to find out if it will be useful in treating patients with other cancer types which have the same molecular alteration (ROS1-positive). If the results are positive, the study team will work with the NHS and the Cancer Drugs Fund to see if these drugs can be routinely accessed for patients in the future.
This trial is part of a trial programme called DETERMINE. The programme will also look at other anti-cancer drugs in the same way, through matching the drug to rare cancer types or ones with specific mutations. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
08/13/2025
Locations: Belfast City Hospital, Belfast, Not set +26 locations
Belfast City Hospital, Belfast, Not set
University Hospital Birmingham, Birmingham, Not set
Birmingham Children's Hospital, Birmingham, Not set
Bristol Royal Hospital for Children, Bristol, Not set
Bristol Haematology and Oncology Centre, Bristol, Not set
Addenbrooke's Hospital, Cambridge, Not set
Velindre Cancer Centre, Cardiff, Not set
Cardiff Children's Hospital, Cardiff, Not set
Western General Hospital, Edinburgh, Not set
The Beatson Hospital, Glasgow, Not set
Royal Hospital for Children Glasgow, Glasgow, Not set
Leicester Royal Infirmary, Leicester, Not set
Alder Hey Hospital, Liverpool, Not set
The Royal Marsden Hospital, London Borough of Sutton, Not set
University College London Hospital, London, Not set
Guy's Hospital, London, Not set
Great Ormond Street Hospital, London, Not set
Royal Manchester Children's Hospital, Manchester, Not set
The Christie Hospital, Manchester, Not set
Great North Children's Hospital, Newcastle, Not set
Freeman Hospital, Newcastle, Not set
Churchill Hospital, Oxford, Not set
John Radcliffe Hospital, Oxford, Not set
Weston Park Hospital, Sheffield, Not set
Sheffield's Children's Hospital, Sheffield, Not set
Southampton General Hospital, Southampton, Not set
Clatterbridge Cancer Centre, Wirral, Not set
Conditions: Haematological Malignancy, Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type, Neoplasms by Site, Cancer, Brain Neoplasms, Melanoma, Glioma, Solid Tumour
A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.
Recruiting
ADOPT-LUNG is an international, multicentre, open-label randomised phase III trial. Protocol treatment consists of 3-4 cycles of neoadjuvant durvalumab in combination with platinum-based doublet chemotherapy, followed by surgery. Patients with R0 and R1 only resection will be randomised to receive either adjuvant durvalumab for 12 cycles (experimental arm) or observation (control arm). The primary objective of the study is to determine whether additional adjuvant immunotherapy with durvalumab af... Read More
ADOPT-LUNG is an international, multicentre, open-label randomised phase III trial. Protocol treatment consists of 3-4 cycles of neoadjuvant durvalumab in combination with platinum-based doublet chemotherapy, followed by surgery. Patients with R0 and R1 only resection will be randomised to receive either adjuvant durvalumab for 12 cycles (experimental arm) or observation (control arm). The primary objective of the study is to determine whether additional adjuvant immunotherapy with durvalumab after neoadjuvant chemo-immunotherapy has an effect on disease-free survival (DFS) in patients who do not achieve complete pathological response (pCR) as per local assessment according to the IASLC recommendations. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Chris O'Brien Lifehouse, Camperdown, New South Wales +41 locations
Chris O'Brien Lifehouse, Camperdown, New South Wales
Nepean Hospital, Penrith, New South Wales
Royal North Shore Hospital, St Leonards, New South Wales
Princess Alexandra Hospital, Woolloongabba, Queensland
Flinders Medical Centre, Bedford Park, South Australia
Royal Hobart Hospital, Hobart, Tasmania
Eastern Health, Box Hill, Victoria
Alfred Hospital, Melbourne, Victoria
Peter MacCallum Cancer Centre, Parkville, Victoria
Sir Charles Gairdner Hospital, Nedlands, Western Australia
Wien AKH, Vienna, Not set
Institut Jules Bordet - HUB, Anderlecht, Not set
Antwerp University Hospital, Antwerp, Not set
North Estonia Medical Centre Foundation, Talinn, Not set
CHU Angers, Angers, Not set
Institut Bergonié, Bordeaux, Not set
Le Mans - CHG, Le Mans, Not set
Lyon - Centre Léon Bérard, Lyon, Not set
Beaumont Hospital, Dublin, Not set
St James's Hospital, Dublin, Not set
SS Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Not set
Istituto Oncologico Veneto, Padova, Not set
Perugia Hospital, Perugia, Not set
Istituto Nazionale Tumori "Regina Elena", Rome, Not set
AOUS Policlinico Le Scotte, Siena, Not set
Universita di Verona - Department of Medicine, Verona, Not set
NKI, Amsterdam, Not set
Erasmus MC, Rotterdam, Not set
UMCU, Utrecht, Not set
Kantonsspital Baden, Baden, Not set
Universitätsspital Basel, Basel, Not set
Eoc - Iosi, Bellinzona, Not set
Inselspital Bern, Bern, Not set
HFR Hôpital Fribourgeois, Fribourg, Not set
Kantonsspital St.Gallen, St.Gallen, Not set
Kantonsspital Winterthur, Winterthur, Not set
University Hospital Zurich, Zurich, Not set
Barts Health NHS Trust, London, Not set
Royal Marsden Hospital (Chelsea), London, Not set
Royal Marsden Hospital (Sutton), London, Not set
Maidstone and Tunbridge Wells NHS Trust, Maidstone, Not set
Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, Not set
Conditions: Non Small Cell Lung Cancer
Comparison Between Rituximab Plus Zanubrutinib Versus Rituximab Monotherapy in Untreated SMZL Patients
Recruiting
The goal of this clinical trial is to compare the efficacy and tolerability of the combination of two medicinal products, rituximab, and zanubrutinib, compared to rituximab monotherapy in patients with Splenic Marginal Zone Lymphoma (SMZL), previously untreated and who need systemic treatment.
The main questions it aims to answer are:
* Is the combination rituximab and zanubrutinib a more effective therapy than rituximab monotherapy?
* Is the combination therapy, rituximab and zanubrutinib, we... Read More
The goal of this clinical trial is to compare the efficacy and tolerability of the combination of two medicinal products, rituximab, and zanubrutinib, compared to rituximab monotherapy in patients with Splenic Marginal Zone Lymphoma (SMZL), previously untreated and who need systemic treatment.
The main questions it aims to answer are:
* Is the combination rituximab and zanubrutinib a more effective therapy than rituximab monotherapy?
* Is the combination therapy, rituximab and zanubrutinib, well tolerated?
Study participants will be put into one of the two treatment groups (rituximab and zanubrutinib or rituximab alone) for a maximum of two years and will undergo regular visits until three years from treatment start. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Medical University of Vienna, Vienna, Not set +55 locations
Medical University of Vienna, Vienna, Not set
Aarhus University Hospital, Aarhus, Not set
Institut Bergonié, Bordeaux, Not set
CHU de Grenoble, Grenoble, Not set
Hôpital Saint Louis, Paris, Not set
Hôpital Lyon-Sud, Pierre-Bénite, Not set
CHRU Nancy Brabois, Vandœuvre-lès-Nancy, Not set
IRCCS Istituto Tumori Giovanni Paolo II, Bari, Not set
IRCCS AOU di Bologna, Bologna, Not set
ASST Spedali Civili di Brescia, Brescia, Not set
A.O.U. Policlinico G. Rodolico-S. Marco, Catania, Not set
IRCCS IRST Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori", Meldola, Not set
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Not set
IRCCS Ospedale San Raffaele, Milan, Not set
ASST Grande Ospedale Metropolitano Niguarda, Milan, Not set
Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Not set
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, Not set
IRCCS Policlinico San Matteo, Pavia, Not set
Ospedale Santa Maria delle Croci, Ravenna, Not set
Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, Not set
USL-IRCCS of Reggio Emilia, Arcispedale Santa Maria Nuova, Reggio Emilia, Not set
Policlinico Santa Maria alle Scotte, Siena, Not set
Ospedale di Circolo e Fondazione Macchi - ASST dei Sette Laghi, Varese, Not set
Oslo University Hospital, Oslo, Not set
St Olavs Hospital, Trondheim, Not set
Hospedal Clinic de Barcelona, Barcelona, Not set
Hospital del Mar, Barcelona, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Istitut Català d'Oncologia, Hospital Duran i Reynals, Barcelona, Not set
Hospital Universitario Cruces, Bilbao, Not set
Hospital Virgen Arrixaca, El Palmar, Not set
Clinica Universidad de Navarra, Madrid, Not set
Hospital 12 De Octubre, Madrid, Not set
Hospital Gregorio Marañón, Madrid, Not set
Hospital Ramon y Cajal, Madrid, Not set
Clinica Universidad de Navarra, Pamplona, Not set
Hospital De Salamanca, Salamanca, Not set
Hospital De Donostia, San Sebastián, Not set
Hospital Clinico De Valencia, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Karolinska University Hospital, Stockholm, Not set
Oncology Institute of Southern Switzerland, Bellinzona, Not set
INSELSPITAL, Bern University Hospital, Bern, Not set
Birmingham Hearthland Hospital, Birmingham, Not set
University Hospitals Dorset, Bournemouth, Not set
University Hospital of Wales, Cardiff, Not set
Hospital Beatson West of Scotland Cancer Centre, Glasgow, Not set
Leicester Royal Infirmary, Leicester, Not set
Clatterbridge Cancer Centre, Liverpool, Not set
University College London Hospitals, London, Not set
Guy's Hospital - Guy's and St. Thomas' NHS Foundation Trust, London, Not set
The Christie, Manchester, Not set
Churchill Hospital, Oxford, Not set
Derriford Hospital, Plymouth, Not set
University Hospitals Southampton, Southampton, Not set
The Royal Marsden NHS Foundation Trust, Sutton, Not set
Conditions: Splenic Marginal Zone Lymphoma
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Recruiting
The goal of this Phase 3 clinical trial is to compare the efficacy of niraparib versus temozolomide (TMZ) in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma multiforme (GBM). The main questions it aims to answer are:
Does niraparib improve progression-free survival (PFS) compared to TMZ?
Does niraparib improve overall survival (OS) compared to TMZ?
Participants will be randomly assigned to one of two treatment arms: niraparib or TMZ.
* study drug (Niraparib) or
* comp... Read More
The goal of this Phase 3 clinical trial is to compare the efficacy of niraparib versus temozolomide (TMZ) in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma multiforme (GBM). The main questions it aims to answer are:
Does niraparib improve progression-free survival (PFS) compared to TMZ?
Does niraparib improve overall survival (OS) compared to TMZ?
Participants will be randomly assigned to one of two treatment arms: niraparib or TMZ.
* study drug (Niraparib) or
* comparator drug (Temozolomide - which is the standard approved treatment for MGMT unmethylated glioblastoma).
The study medication will be taken daily while receiving standard of care radiation therapy (RT) for 6-7 weeks.
Participants may continue to take the niraparib or TMZ adjuvantly as long as the cancer does not get worse or completion of 6 cycles of treatment (TMZ). A total of 450 participants will be enrolled in the study.
Participants' tasks will include:
* Complete study visits as scheduled
* Complete a diary to record study medication Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Ivy Brain Tumor Center, Phoenix, Arizona +50 locations
Ivy Brain Tumor Center, Phoenix, Arizona
Scripps Cancer Center, La Jolla, California
Moores UCSD Cancer Center, La Jolla, California
The NeuroMedical Center, Baton Rouge, Louisiana
MaineHealth Maine Medical Center Care, South Portland, Maine
University of Minnesota Health Clinics and Surgery Center, Minneapolis, Minneapolis, Minnesota
Northwell Health, New Hyde Park, New York
New York University Ambulatory Care Center, New York, New York
Duke Cancer Center Brain Tumor Clinic, Durham, North Carolina
The Cleveland Clinic Foundation, Cleveland, Ohio
The Ohio State University, Columbus, Ohio
Thomas Jefferson University, Philadelphia, Pennsylvania
The University of Vermont Medical Center, Burlington, Vermont
University of Washington Medical Center, Seattle, Washington
University of Wisconsin Cancer Center, Madison, Wisconsin
Peter MacCallum Cancer Centre, Melbourne, Victoria
The Alfred Hospital, Melbourne, Victoria
CHU Nice - Hôpital Pasteur, Nice, Alpes Maritimes
Hôpital de la Timone, Marseille cedex 05, Bouches-du-Rhône
Institut du Cancer de Montpellier, Montpellier Cedex 5, Herault
ICO - Site René Gauducheau, Saint-Herblain, Loire Atlantique
Centre Hospitalier Universitaire de Lyon-Hospices Civils de Lyon-Hopital Pierre Wertheimer, Bron, Rhone
Centre Leon Berard, Lyon, Rhone
CHU Amiens-Picardie - Site Sud, Amiens, Somme
Centre Georges François Leclerc, Dijon Cedex, Not set
Groupe Hospitalier Pitie-Salpetriere, Paris, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Baden Wuerttemberg
Universitaetsmedizin Mannheim, Mannheim, Baden Wuerttemberg
Universitaetsklinikum Tuebingen, Tübingen, Baden Wuerttemberg
Universitaetsklinikum Bonn AoeR, Bonn, Nordrhein Westfalen
Klinikum Chemnitz gGmbH, Chemnitz, Sachsen
Universitaetsklinikum Leipzig, Leipzig, Sachsen
Istituto Clinico Humanitas, Rozzano, Milano
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Not set
Azienda Ospedaliera Universitaria Careggi, Firenze, Not set
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Not set
Maastricht UMC, Maastricht, Not set
UMC Utrecht, Utrecht, Not set
Oslo Universitetssykehus HF, Radiumhospitalet, Oslo, Not set
Clinica Universidad de Navarra, Pamplona, Navarra
Hospital del Mar, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital Universitario Reina Sofia, Córdoba, Not set
ICO Girona - Hospital Universitari de Girona Dr Josep Trueta, Girona, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario HM Madrid Sanchinarro, Madrid, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
The Christie Hospital, Manchester, Greater Manchester
The Clatterbridge Cancer Centre, Wirral, Merseyside
Conditions: Glioblastoma, GBM, Brain Neoplasms, Adult, Malignant, Brain Tumor
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