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All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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A Study to Evaluate Tobevibart+Elebsiran in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide
Recruiting
This is a multicenter, open label, randomized Phase 3 clinical study to evaluate tobevibart + elebsiran in participants with Chronic HDV Infection not virologically suppressed with bulevirtide
This is a multicenter, open label, randomized Phase 3 clinical study to evaluate tobevibart + elebsiran in participants with Chronic HDV Infection not virologically suppressed with bulevirtide Read Less
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/13/2025
Locations: Investigative Site, Bobigny, Not set +11 locations
Investigative Site, Bobigny, Not set
Investigative Site, Clichy, Not set
Investigative Site, Le Chesnay, Not set
Investigative Site, Limoges, Not set
Investigative Site, Toulouse, Not set
Investigative Site, Villejuif, Not set
Investigative Site, Bucuresti, Not set
Investigative Site, Bucuresti, Not set
Investigative Site, Bucuresti, Not set
Investigative Site, Craiova, Not set
Investigative Site, London, Not set
Investigative Site, Nottingham, Not set
Conditions: Viral Hepatitis
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
Recruiting
The goal of this Phase 3 clinical trial is to compare the efficacy of niraparib versus temozolomide (TMZ) in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma multiforme (GBM). The main questions it aims to answer are:
Does niraparib improve progression-free survival (PFS) compared to TMZ?
Does niraparib improve overall survival (OS) compared to TMZ?
Participants will be randomly assigned to one of two treatment arms: niraparib or TMZ.
* study drug (Niraparib) or
* comp... Read More
The goal of this Phase 3 clinical trial is to compare the efficacy of niraparib versus temozolomide (TMZ) in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma multiforme (GBM). The main questions it aims to answer are:
Does niraparib improve progression-free survival (PFS) compared to TMZ?
Does niraparib improve overall survival (OS) compared to TMZ?
Participants will be randomly assigned to one of two treatment arms: niraparib or TMZ.
* study drug (Niraparib) or
* comparator drug (Temozolomide - which is the standard approved treatment for MGMT unmethylated glioblastoma).
The study medication will be taken daily while receiving standard of care radiation therapy (RT) for 6-7 weeks.
Participants may continue to take the niraparib or TMZ adjuvantly as long as the cancer does not get worse or completion of 6 cycles of treatment (TMZ). A total of 450 participants will be enrolled in the study.
Participants' tasks will include:
* Complete study visits as scheduled
* Complete a diary to record study medication Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Ivy Brain Tumor Center, Phoenix, Arizona +50 locations
Ivy Brain Tumor Center, Phoenix, Arizona
Scripps Cancer Center, La Jolla, California
Moores UCSD Cancer Center, La Jolla, California
The NeuroMedical Center, Baton Rouge, Louisiana
MaineHealth Maine Medical Center Care, South Portland, Maine
University of Minnesota Health Clinics and Surgery Center, Minneapolis, Minneapolis, Minnesota
Northwell Health, New Hyde Park, New York
New York University Ambulatory Care Center, New York, New York
Duke Cancer Center Brain Tumor Clinic, Durham, North Carolina
The Cleveland Clinic Foundation, Cleveland, Ohio
The Ohio State University, Columbus, Ohio
Thomas Jefferson University, Philadelphia, Pennsylvania
The University of Vermont Medical Center, Burlington, Vermont
University of Washington Medical Center, Seattle, Washington
University of Wisconsin Cancer Center, Madison, Wisconsin
Peter MacCallum Cancer Centre, Melbourne, Victoria
The Alfred Hospital, Melbourne, Victoria
CHU Nice - Hôpital Pasteur, Nice, Alpes Maritimes
Hôpital de la Timone, Marseille cedex 05, Bouches-du-Rhône
Institut du Cancer de Montpellier, Montpellier Cedex 5, Herault
ICO - Site René Gauducheau, Saint-Herblain, Loire Atlantique
Centre Hospitalier Universitaire de Lyon-Hospices Civils de Lyon-Hopital Pierre Wertheimer, Bron, Rhone
Centre Leon Berard, Lyon, Rhone
CHU Amiens-Picardie - Site Sud, Amiens, Somme
Centre Georges François Leclerc, Dijon Cedex, Not set
Groupe Hospitalier Pitie-Salpetriere, Paris, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Baden Wuerttemberg
Universitaetsmedizin Mannheim, Mannheim, Baden Wuerttemberg
Universitaetsklinikum Tuebingen, Tübingen, Baden Wuerttemberg
Universitaetsklinikum Bonn AoeR, Bonn, Nordrhein Westfalen
Klinikum Chemnitz gGmbH, Chemnitz, Sachsen
Universitaetsklinikum Leipzig, Leipzig, Sachsen
Istituto Clinico Humanitas, Rozzano, Milano
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Not set
Azienda Ospedaliera Universitaria Careggi, Firenze, Not set
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Not set
Maastricht UMC, Maastricht, Not set
UMC Utrecht, Utrecht, Not set
Oslo Universitetssykehus HF, Radiumhospitalet, Oslo, Not set
Clinica Universidad de Navarra, Pamplona, Navarra
Hospital del Mar, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital Universitario Reina Sofia, Córdoba, Not set
ICO Girona - Hospital Universitari de Girona Dr Josep Trueta, Girona, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario HM Madrid Sanchinarro, Madrid, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
The Christie Hospital, Manchester, Greater Manchester
The Clatterbridge Cancer Centre, Wirral, Merseyside
Conditions: Glioblastoma, GBM, Brain Neoplasms, Adult, Malignant, Brain Tumor
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Recruiting
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxaliplatin (mFOLFOX6) or 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus cetuximab and mFOLFOX6 or FOLFIRI in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS)/ Neuroblastoma R... Read More
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxaliplatin (mFOLFOX6) or 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus cetuximab and mFOLFOX6 or FOLFIRI in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS)/ Neuroblastoma RAS viral oncogene homolog (NRAS) and v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) wild type (WT) unresectable or metastatic left-sided colorectal cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +221 locations
Banner MD Anderson Cancer Center, Gilbert, Arizona
St. Bernard's Medical Center, Jonesboro, Arkansas
CBCC Global Research, Bakersfield, California
Los Angeles Cancer Network, Glendale, California
Cancer and Blood Specialty Clinic, Los Alamitos, California
USC Norris Comprehensive Cancer Center, Los Angeles, California
UCLA, Santa Monica, California
Providence Medical Foundation, Santa Rosa, California
Torrance Memorial Physicians Network, Torrance, California
Rocky Mountain Cancer Centers, Denver, Colorado
Yale University School Of Medicine, New Haven, Connecticut
Georgetown Univ Medical Center Lombardi Cancer Center, Washington, District of Columbia
Florida Cancer Specialists South, Fort Myers, Florida
AdventHealth Medical Group Oncology and Hematology at Orlando, Orlando, Florida
Florida Cancer Specialists North Region, Saint Petersburg, Florida
Florida Cancer Specialists East, West Palm Beach, Florida
Grady Memorial Hospital, Atlanta, Georgia
Winship Cancer Institute Emory University, Atlanta, Georgia
Fort Wayne Medical Oncology & Hematology, Fort Wayne, Indiana
Ochsner Clinic Foundation, New Orleans, Louisiana
MedStar Franklin Square Medical Center, Baltimore, Maryland
VA Ann Arbor Healthcare System, Ann Arbor, Michigan
University of Michigan, Ann Arbor, Michigan
Henry Ford Hospital, Detroit, Michigan
Hattiesburg Clinic, Hattiesburg, Mississippi
Washington University School Of Medicine, Saint Louis, Missouri
Nebraska Cancer Specialists Midwest Cancer Center, Omaha, Nebraska
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Astera Cancer Care, East Brunswick, New Jersey
Rutgers Cancer Institute, New Brunswick, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Montefiore Einstein Comprehensive Cancer Center, Bronx, New York
Perlmutter Cancer Center at NYU Long Island, Mineola, New York
Mount Sinai, New York, New York
Mount Sinai West, New York, New York
NYU Langone Medical Center NYU Hematology Associates, New York, New York
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York, New York
New York Cancer and Blood Specialists, Shirley, New York
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center Fairview Hospital Moll Pavilion, Cleveland, Ohio
Taussig Cancer Insititute Cleveland Clinic, Cleveland, Ohio
Cleveland Clinic Cancer Center Independence Family Health Center, Independence, Ohio
Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio
Cleveland Clinic Cancer Center Hillcrest Hospital, Mayfield Heights, Ohio
Cleveland Clinic Cancer Centers Sandusky, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
Cleveland Clinic Cancer Center South Pointe Hospital, Warrensville Heights, Ohio
Wooster Milltown Specialty and Surgery Center, Wooster, Ohio
Thomas Jefferson University, Philadelphia, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
SCRI Oncology Partners, Nashville, Tennessee
Texas Oncology West Texas, Abilene, Texas
Texas Oncology DFW, Dallas, Texas
MD Anderson Cancer Center, Houston, Texas
Texas Oncology - San Antonio, San Antonio, Texas
Baylor Scott and White Health, Temple, Texas
Virginia Cancer Specialists, Arlington, Virginia
Inova Schar Cancer Institute Dept of Fairfax Hospital, Fairfax, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Swedish Cancer Institute, Edmonds, Washington
Swedish Cancer Institute, Issaquah, Washington
Swedish Cancer Institute, Seattle, Washington
William S. Middleton Memorial VA, Madison, Wisconsin
Institut Jules Bordet, Anderlecht, Not set
Universitair Ziekenhuis Antwerpen, Edegem, Not set
AZ Maria Middelares, Gent, Not set
Hopital de Jolimont, Haine Saint Paul La Louviere, Not set
Az Groeninge, Kortrijk, Not set
Universitair Ziekenhuis Leuven, Leuven, Not set
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman, Liege, Not set
Fundacao Pio XII, Barretos, Not set
Fundacao Universidade de Caxias do Sul, Caxias do Sul, Not set
Fundacao Doutor Amaral Carvalho, Jau, Not set
Hospital Nossa Senhora da Conceicao S A, Porto Alegre, Not set
Hospital Santa Izabel Santa Casa de Misericordia da Bahia, Salvador, Not set
Clinica de Hematologia e Oncologia Viver Ltda, Santa Maria, Not set
Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base, Sao Jose do Rio Preto, Not set
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Not set
Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, Not set
Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia, Vitoria, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Ottawa Hospital, Ottawa, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Centre de Recherche du CHUM, Montreal, Quebec
Peking University First Hospital, Beijing, Not set
Beijing Friendship Hospital Capital Medical University, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
Peking University Third Hospital, Beijing, Not set
The First Bethune Hospital of Jilin University, Changchun, Not set
Hunan Cancer hospital, Changsha, Not set
Sun Yat Sen University Cancer Center, Guangzhou, Not set
The Sixth Affiliated Hospital Sun Yat sen University, Guangzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The First Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Not set
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin medical university cancer hospital, Harbin, Not set
Huizhou Central People's Hospital, Huizhou, Not set
The First Affiliated Hospital of NanChang University, Nanchang, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Liaoning Cancer Hospital and Institute, Shenyang, Not set
Peking University Shenzhen Hospital, Shenzhen, Not set
West China Hospital of Sichuan University, Sichuan, Not set
First Hospital of Shanxi Medical University, Taiyuan, Not set
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Not set
Hubei Cancer Hospital, Wuhan, Not set
Institut Sainte Catherine, Avignon Cedex 9, Not set
Hopital Claude Huriez, Lille, Not set
Hopital Prive Jean Mermoz, Lyon, Not set
Institut du Cancer de Montpellier, Montpellier, Not set
CHU Nantes, Nantes Cedex 1, Not set
Hopital Saint Antoine, Paris, Not set
Hopital Haut Leveque, Pessac, Not set
CHU De Poitiers, Poitiers Cedex, Not set
Gustave Roussy, Villejuif, Not set
Charite Universitatsmedizin Berlin Campus Virchow Klinikum, Berlin, Not set
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden, Not set
Essen University Hospital, Essen, Not set
Krankenhaus NorthWest, Frankfurt am Main, Not set
Praxis fur interdisziplinare Onkologie & Hamatologie GbR, Freiburg, Not set
Asklepios Klinik Altona, Hamburg, Not set
National Center for Tumor Diseases NCT, Heidelberg, Not set
Universitatsmedizin der Johannes Gutenberg Universitat Mainz, Mainz, Not set
Klinikum der Universitaet Muenchen, Munich, Not set
Universitatsklinikum Ulm, Ulm, Not set
Semmelweis Egyetem, Budapest, Not set
Markhot Ferenc Oktatokorhaz es Rendelointezet, Eger, Not set
Pecsi Tudomanyegyetem, Pecs, Not set
Szegedi Tudomanyegyetem, Szeged, Not set
Rajiv Gandhi Cancer Institute and Research Centre, Delhi, Not set
B P Poddar Hospital and Medical research Limited, Kolkata, Not set
Tata Memorial Hospital, Mumbai, Not set
Deenanath Mangeshkar Hospital and Research Centre, Pune, Not set
Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, Not set
Yitzhak Shamir Medical Center, Beer Yaakov, Not set
Rambam Medical Center, Haifa, Not set
Hadassah University Hospita Ein Kerem, Jerusalem, Not set
Rabin Medical Center, Petah Tikva, Not set
Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv Yafo, Not set
Assuta MC, Tel Aviv Yafo, Not set
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Not set
Istituto Dei Tumori Di Milano, Milano, Not set
Istituto Oncologico Veneto - IRCCS, Padova, Not set
Azienda Ospedaliero Universitaria Pisana, Pisa, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Chiba Cancer Center, Chiba, Not set
National Cancer Center Hospital, Chuo Ku, Not set
National Cancer Center Hospital East, Kashiwa, Not set
Aichi Cancer Center, Nagoya Shi, Not set
Osaka International Cancer Institute, Osaka City, Not set
National Hospital Organization Osaka National Hospital, Osaka-Shi, Not set
Shizuoka Cancer Center, Shizuoka, Not set
The University of Osaka Hospital, Suita City, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Marys Hospital, Seoul, Not set
Hospital Canselor Tuanku Muhriz UKM, Cheras, Not set
Hospital Pulau Pinang, Georgetown, Not set
Hospital Raja Permaisuri Bainun, Ipoh, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Hospital Umum Sarawak, Kuching, Not set
National Cancer Institute, Putrajaya, Not set
Meander Medisch Centrum, Amersfoort, Not set
Antoni van Leeuwenhoek, Amsterdam, Not set
Radboud University Medical Center, Nijmegen, Not set
Erasmus MC, Rotterdam, Not set
Elisabeth-TweeSteden Ziekenhuis, Tilburg, Not set
UMC Utrecht, Utrecht, Not set
Wojewodzki Szpital Specjalistyczny, Biala Podlaska, Not set
Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku, Bialystok, Not set
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozow, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach, Gliwice, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie, Olsztyn, Not set
SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego, Opole, Not set
Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie, Warszawa, Not set
Pan American Center for Oncology Trials LLC, Barrio Monacillos, Not set
Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set
Hosp. Univ. Ramon Y Cajal, Madrid, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Clinica Univ. de Navarra, Pamplona, Not set
Hosp. Virgen Del Rocio, Sevilla, Not set
Hosp. Clinico Univ. de Valencia, Valencia, Not set
Sahlgrenska University Hospital, Goteborg, Not set
Skanes universitetssjukhus, Lund, Not set
Sodersjukhuset, Stockholm, Not set
Karolinska Universitetssjukhuset, Stockholm, Not set
Uppsala University, Uppsala, Not set
Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital, Taoyuan, Not set
Adana City Hospital, Adana, Not set
Gulhane Egitim ve Arastirma Hastanesi, Ankara, Not set
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Not set
Gazi University Hospital, Ankara, Not set
Ankara Bilkent Sehir Hastanesi, Ankara, Not set
Bakirkoy Training and Research Hospital, Istanbul, Not set
Marmara University Pendik Training Hospital, İstanbul, Not set
Necmettin Erbakan University Meram Medical Faculty, Konya, Not set
Sakarya University Training and Research Hospital, Sakarya, Not set
Birmingham Heartlands Hospital, Birmingham, Not set
Addenbrooke's Hospital, Cambridge, Not set
Western General Hospital, Edinburgh, Not set
Castle Hill Hospital, Hull, Not set
St James University Hospital, Leeds, Not set
St Bartholomew's Hospital, London, Not set
University College Hospital, London, Not set
Mount Vernon Cancer Centre, Northwood, Not set
Royal Marsden Hospital (Sutton), Sutton, Not set
Conditions: Colorectal Neoplasms
Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
Recruiting
This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of AZD5305 when given in combination with new hormonal agents (NHAs) in patients with Metastatic Prostate Cancer.
This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of AZD5305 when given in combination with new hormonal agents (NHAs) in patients with Metastatic Prostate Cancer. Read Less
Gender:
MALE
Ages:
Between 18 years and 130 years
Trial Updated:
08/13/2025
Locations: Research Site, San Diego, California +26 locations
Research Site, San Diego, California
Research Site, Indianapolis, Indiana
Research Site, Detroit, Michigan
Research Site, Detroit, Michigan
Research Site, Syracuse, New York
Research Site, Philadelphia, Pennsylvania
Research Site, Myrtle Beach, South Carolina
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, Camperdown, Not set
Research Site, Darlinghurst, Not set
Research Site, East Melbourne, Not set
Research Site, Heidelberg, Not set
Research Site, Melbourne, Not set
Research Site, St Leonards, Not set
Research Site, Candiolo, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Orbassano, Not set
Research Site, Padova, Not set
Research Site, Pavia, Not set
Research Site, Cambridge, Not set
Research Site, Glasgow, Not set
Research Site, Hampshire, Not set
Research Site, Manchester, Not set
Research Site, Newcastle Upon Tyne, Not set
Research Site, Plymouth, Not set
Conditions: Metastatic Prostate Cancer
A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.
Recruiting
ADOPT-LUNG is an international, multicentre, open-label randomised phase III trial. Protocol treatment consists of 3-4 cycles of neoadjuvant durvalumab in combination with platinum-based doublet chemotherapy, followed by surgery. Patients with R0 and R1 only resection will be randomised to receive either adjuvant durvalumab for 12 cycles (experimental arm) or observation (control arm). The primary objective of the study is to determine whether additional adjuvant immunotherapy with durvalumab af... Read More
ADOPT-LUNG is an international, multicentre, open-label randomised phase III trial. Protocol treatment consists of 3-4 cycles of neoadjuvant durvalumab in combination with platinum-based doublet chemotherapy, followed by surgery. Patients with R0 and R1 only resection will be randomised to receive either adjuvant durvalumab for 12 cycles (experimental arm) or observation (control arm). The primary objective of the study is to determine whether additional adjuvant immunotherapy with durvalumab after neoadjuvant chemo-immunotherapy has an effect on disease-free survival (DFS) in patients who do not achieve complete pathological response (pCR) as per local assessment according to the IASLC recommendations. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Chris O'Brien Lifehouse, Camperdown, New South Wales +41 locations
Chris O'Brien Lifehouse, Camperdown, New South Wales
Nepean Hospital, Penrith, New South Wales
Royal North Shore Hospital, St Leonards, New South Wales
Princess Alexandra Hospital, Woolloongabba, Queensland
Flinders Medical Centre, Bedford Park, South Australia
Royal Hobart Hospital, Hobart, Tasmania
Eastern Health, Box Hill, Victoria
Alfred Hospital, Melbourne, Victoria
Peter MacCallum Cancer Centre, Parkville, Victoria
Sir Charles Gairdner Hospital, Nedlands, Western Australia
Wien AKH, Vienna, Not set
Institut Jules Bordet - HUB, Anderlecht, Not set
Antwerp University Hospital, Antwerp, Not set
North Estonia Medical Centre Foundation, Talinn, Not set
CHU Angers, Angers, Not set
Institut Bergonié, Bordeaux, Not set
Le Mans - CHG, Le Mans, Not set
Lyon - Centre Léon Bérard, Lyon, Not set
Beaumont Hospital, Dublin, Not set
St James's Hospital, Dublin, Not set
SS Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Not set
Istituto Oncologico Veneto, Padova, Not set
Perugia Hospital, Perugia, Not set
Istituto Nazionale Tumori "Regina Elena", Rome, Not set
AOUS Policlinico Le Scotte, Siena, Not set
Universita di Verona - Department of Medicine, Verona, Not set
NKI, Amsterdam, Not set
Erasmus MC, Rotterdam, Not set
UMCU, Utrecht, Not set
Kantonsspital Baden, Baden, Not set
Universitätsspital Basel, Basel, Not set
Eoc - Iosi, Bellinzona, Not set
Inselspital Bern, Bern, Not set
HFR Hôpital Fribourgeois, Fribourg, Not set
Kantonsspital St.Gallen, St.Gallen, Not set
Kantonsspital Winterthur, Winterthur, Not set
University Hospital Zurich, Zurich, Not set
Barts Health NHS Trust, London, Not set
Royal Marsden Hospital (Chelsea), London, Not set
Royal Marsden Hospital (Sutton), London, Not set
Maidstone and Tunbridge Wells NHS Trust, Maidstone, Not set
Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, Not set
Conditions: Non Small Cell Lung Cancer
A Study of AMG 193 in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
Recruiting
The primary objective of Parts 1 and 2 of this study is to evaluate the safety, tolerability, and to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of AMG 193 alone and in combination with docetaxel in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-null solid tumors.
The primary objective of Part 3 of this study is to evaluate the efficacy of AMG 193 in adult participants with metastatic or locally advanced MTAP-nul... Read More
The primary objective of Parts 1 and 2 of this study is to evaluate the safety, tolerability, and to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of AMG 193 alone and in combination with docetaxel in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-null solid tumors.
The primary objective of Part 3 of this study is to evaluate the efficacy of AMG 193 in adult participants with metastatic or locally advanced MTAP-null solid tumors. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/13/2025
Locations: City of Hope National Medical Center, Duarte, California +74 locations
City of Hope National Medical Center, Duarte, California
California Research Institute, Glendale, California
Fomat Medical Research, Oxnard, California
University of California at SF, San Francisco, California
D and H Cancer Research Center, Margate, Florida
Boca Raton Clinical Research Medical Center Inc, Tamarac, Florida
Goshen Health Systems, Goshen, Indiana
Indiana University, Indianapolis, Indiana
Community Health Network MD Anderson Cancer Center - North, Indianapolis, Indiana
University of Maryland Medical Center, Baltimore, Maryland
American Oncology Partners, PA, Bethesda, Maryland
Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion), Detroit, Michigan
Washington University, Saint Louis, Missouri
Rutgers Cancer Institute of NJ, New Brunswick, New Jersey
Roswell Park Cancer Institute, Buffalo, New York
Northwell Health Monter Cancer Center, Lake Success, New York
New York University Grossman School of Medicine and New York University Langone Hospitals, New York, New York
Duke University, Durham, North Carolina
University Hospitals Cleveland Medical Center, Cleveland, Ohio
University of Pennsylvania, Philadelphia, Pennsylvania
Thomas Jefferson University, Philadelphia, Pennsylvania
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Sanford Oncology Clinic and Pharmacy, Sioux Falls, South Dakota
Mary Crowley Cancer Research, Dallas, Texas
Center for Oncology and Blood Disorders, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
Lumi Research, Kingwood, Texas
South Texas Accelerated Research Therapeutics, San Antonio, Texas
University of Virginia Cancer Center, Charlottesville, Virginia
Virginia Cancer Specialists PC, Fairfax, Virginia
Chris OBrien Lifehouse, Camperdown, New South Wales
Epworth Healthcare, East Melbourne, Victoria
Peter MacCallum Cancer Centre, Parkville, Victoria
Medizinische Universitaet Graz, Graz, Not set
Landeskrankenhaus Salzburg, Salzburg, Not set
Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Bruxelles, Not set
Universitair Ziekenhuis Antwerpen, Edegem, Not set
Universitair Ziekenhuis Gent, Gent, Not set
Jessa Ziekenhuis - Campus Virga Jesse, Hasselt, Not set
Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Not set
Cross Cancer Institute, Edmonton, Alberta
Princess Margaret Cancer Centre, Toronto, Ontario
Chongqing University Cancer Hospital, Chongqing, Chongqing
Fujian Cancer Hospital, Fuzhou, Fujian
Mengchao Hepatobiliary hospital of Fujian Medical University, Fuzhou, Fujian
Shanghai East Hospital, Shanghai, Shanghai
Shanghai Pulmonary Hospital, Shanghai, Shanghai
Centre Georges Francois Leclerc, Dijon, Not set
Centre Oscar Lambret, Lille, Not set
Hopitaux Universitaires Pitie Salpetriere - Charles Foix, Paris, Not set
Gustave Roussy, Villejuif, Not set
Universitaetsklinikum Halle - Saale, Halle (Saale), Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Universitaetsklinikum Ulm, Ulm, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
Queen Mary Hospital, The University of Hong Kong, Hong Kong, Not set
Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Not set
Aichi Cancer Center, Nagoya-shi, Aichi
National Cancer Center Hospital East, Kashiwa-shi, Chiba
National Cancer Center Hospital, Chuo-ku, Tokyo
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Istituto Oncologico della Svizzera Italiana, Bellinzona, Not set
Inselspital Bern, Bern, Not set
Hopitaux Universitaires de Geneve, Geneve 14, Not set
Kantonsspital Sankt Gallen, Sankt Gallen, Not set
Universitaetsspital Zuerich, Zuerich, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan, Not set
Sarah Cannon Research Institute UK, London, Not set
Royal Marsden Hospital, Sutton, Not set
Conditions: Advanced MTAP-null Solid Tumors
Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
Recruiting
The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.
The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight. Read Less
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
08/13/2025
Locations: Pinnacle Research Group LLC, Anniston, Alabama +242 locations
Pinnacle Research Group LLC, Anniston, Alabama
Alliance For Multispecialty Research - Daphne, Daphne, Alabama
Alliance for Multispecialty Research Mobile, Mobile, Alabama
Avacare Foothills Research Center, Phoenix, Arizona
Ark Clinical Research- Tustin, Fountain Valley, California
Long Beach Clinical Trials Services Inc, Long Beach, California
Ark Clinical Research- Long Beach, Long Beach, California
Catalina Research Institute, Montclair, California
Artemis Institute for Clinical Research, Riverside, California
Artemis Institute for Clinical Research, San Diego, California
Apex Clinical Research, San Diego, California
Southern California Clinical Research, Santa Ana, California
Diablo Clinical Research, Walnut Creek, California
Yale School of Medicine, New Haven, Connecticut
Chase Medical Research LLC, Waterbury, Connecticut
Indago Research and Health Center, Hialeah, Florida
Jacksonville Center for Clinical Research, Jacksonville, Florida
Clinical Neuroscience Solutions - Jacksonville, Jacksonville, Florida
South Florida Wellness and Clinical Research Institute, Margate, Florida
Optimus U Corporation, Miami, Florida
Research Institute of South Florida, Miami, Florida
Renstar Medical Research, Ocala, Florida
Clinical Neuroscience Solutions - Orlando, Orlando, Florida
Combined Research Orlando Phase I IV, Orlando, Florida
Florida Institute for Clinical Research, Orlando, Florida
Encore Medical Research of Weston LLC, Weston, Florida
Center for Advanced Research and Education, Gainesville, Georgia
Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group, Union City, Georgia
East-West Medical Research, Honolulu, Hawaii
Solaris Clinical Research, Meridian, Idaho
Flourish Research - Great Lakes Clinical Trials, Chicago, Illinois
Endeavor Health Medical Group - Endocrinology and Diabetes- Skokie, Skokie, Illinois
Evanston Premier Healthcare Research LLC, Skokie, Illinois
Alliance for Multispecialty Research Newton, Newton, Kansas
Louisville Metabolic and Atherosclerosis Research Center, Louisville, Kentucky
Velocity Clinical Research - Baton Rouge, Baton Rouge, Louisiana
Tandem Clinical Research - Marrero, Marrero, Louisiana
Headlands Research - Detroit, Southfield, Michigan
Prime Health and Wellness Sky Clinical Research Network Group, Fayette, Mississippi
Alliance for Multispecialty Research - Kansas City, Kansas City, Missouri
Palm Research Center Inc, Las Vegas, Nevada
Vector Clinical Trials, Las Vegas, Nevada
Rochester Clinical Research, Rochester, New York
Velocity Clinical Research- Binghamton, Vestal, New York
Accellacare of Hickory, Hickory, North Carolina
Carolina Research Center Inc, Shelby, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Clinical Trial Investigator Clinical Research Center, Cincinnati, Ohio
Velocity Clinical Research - Cincinnati, Cincinnati, Ohio
Alliance for Multispecialty Research - Norman, Norman, Oklahoma
Capital Area Research LLC, Newport, Pennsylvania
Velocity Clinical Research - Providence, East Greenwich, Rhode Island
Tribe Clinical Research LLC Dba Mountain View Clinical Research, Greenville, South Carolina
New Phase Research and Development, Knoxville, Tennessee
Accellacare US Inc., d/b/a Accellacare of Knoxville, Knoxville, Tennessee
Elligo Clinical Research Center, Austin, Texas
Cedar Health Research, LLC, Dallas, Texas
Epic Medical Research - Texas, DeSoto, Texas
Great Lakes Research Institute El Paso Research, El Paso, Texas
Cedar Health Research, LLC, Euless, Texas
Juno Research LLC, Houston, Texas
Biopharma Informatic, LLC, Houston, Texas
Juno Research LLC, Houston, Texas
Southern Endocrinology Associates PA, Mesquite, Texas
Great Lakes Research Institute - McAllen Research, Pharr, Texas
Clinical Trials of Texas, San Antonio, Texas
Sugar Lakes Family Practice, Sugar Land, Texas
Pantheon Clinical Research, Bountiful, Utah
Alliance for Multispecialty Research Layton Research Center, Layton, Utah
Chrysalis Clinical Research, LLC, Saint George, Utah
Washington Center for Weight Management and Research, Inc, Arlington, Virginia
Health Research of Hampton Roads, Newport News, Virginia
Selma Medical Associates, Winchester, Virginia
Allegiance Research Specialists, Milwaukee, Wisconsin
Cedic - Centro de Investigacion Clinica, Caba, Buenos Aires
Centro Medico Viamonte, Caba, Buenos Aires
Cemedic Centro de Especialidades Medicas, Caba, Buenos Aires
Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada, Caba, Buenos Aires
Consultorios Medicos Dr Besada, Caba, Buenos Aires
Fundacion Respirar, Caba, Buenos Aires
Cinme - Centro de Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires, Buenos Aires
Ciprec - Centro de Investigacion y Prevencion Cardiovascular, Ciudad Autonoma de Buenos Aires, Buenos Aires
Emeritus Research Sydney, Botany, New South Wales
Novatrials, Charlestown, New South Wales
Canopy Clinical Sutherland, Miranda, New South Wales
Royal North Shore Hospital, St Leonards, New South Wales
Canopy Clinical Wollongong, Wollongong, New South Wales
Logan Hospital, Meadowbrook, Queensland
Fusion Clinical Research, Norwood, South Australia
Southern Adelaide Diabetes and Endocrine Services, Oaklands Park, South Australia
Canopy Clinical Altona North, Altona North, Victoria
Emeritus Research Camberwell, Camberwell, Victoria
Austin Health, Heidelberg Repatriation Hospital, Heidelberg West, Victoria
Hopital de Warquignies, Boussu, Not set
Universitair Ziekenhuis Antwerpen, Edegem, Not set
Universitair Ziekenhuis Gent, Gent, Not set
Algemeen Ziekenhuis Groeninge - Campus Kennedylaan, Kortrijk, Not set
Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Not set
Centre Hospitalier Universitaire de Liege - Sart Tilman, Liège, Not set
Algemeen Ziekenhuis Sint-Maarten, Mechelen, Not set
tlc Diabetes and Endocrinology, Surrey, British Columbia
Wharton Medical Clinic, Hamilton, Ontario
North York Diagnostic and Cardiac Centre, North York, Ontario
Centricity Research Oshawa Multispecialty, Oshawa, Ontario
Heart Health Institute Research Incorporated, Scarborough, Ontario
Curans Heart Center, Thunder Bay, Ontario
Centricity Research Toronto, Toronto, Ontario
Diabetes Heart Research Centre, Toronto, Ontario
Ecogene-21, Chicoutimi, Quebec
CardioVasc HR Incorporated, St Jean sur Richelieu, Quebec
Centre de Medecine Metabolique de Lanaudiere, Terrebonne, Quebec
Institut Universitaire de cardiologie et de pneumologie de Quebec, Quebec, Not set
Medicus Services sro, Brandys nad Labem, Not set
Fakultni nemocnice Brno, Brno, Not set
Endohope Havirov sro, Havirov, Not set
PreventaMed sro, Olomouc, Not set
CCR Ostrava sro, Ostrava, Not set
Fakultni nemocnice Kralovske Vinohrady, Praha 10, Not set
Ob klinika as, Praha 3, Not set
Institut klinicke a experimentalni mediciny, Praha 4, Not set
Endokrinologie Cerny Most sro, Praha 9, Not set
Vseobecna fakultni nemocnice v Praze, Praha, Not set
Endohope klinika sro, Praha, Not set
Sanos Gandrup, Gandrup, Not set
Gentofte Hospital, Hellerup, Not set
Sanos Clinic, Herlev, Not set
Steno Diabetes Center Copenhagen, Herlev, Not set
Regionshospitalet Godstrup, Herning, Not set
Hvidovre Hospital, Hvidovre, Not set
Obesity Research Unit, Helsinki, Not set
Health Step Finland, Kuopio, Not set
Oulu University Hospital, Oulu, Not set
Universitaetsklinikum Aachen, Aachen, Not set
Kardiologische Praxis Dr med Wolfgang Jungmair, Bad Homburg, Not set
Universitaets-Herzzentrum Freiburg - Bad Krozingen, Bad Krozingen, Not set
Diabetespraxis Bad Mergentheim, Bad Mergentheim, Not set
Universitaetsklinikum der Ruhr-Universitaet Bochum, Bad Oeynhausen, Not set
Charite - Universitaetsmedizin Berlin, Campus Mitte, Berlin, Not set
Velocity Clinical Research GmbH, Berlin, Not set
Diabetespraxis Dr. Hermann Braun, Berlin, Not set
Mvz am Bahnhof Spandau, Berlin, Not set
Universitaetsklinikum Dresden, Dresden, Not set
Zentrum fuer Klinische Studien Suedbrandenburg GmbH, Elsterwerda, Not set
InnoDiab Forschung, Essen, Not set
Praxis am Markt Dr. Bernd Becker, Essen, Not set
Schwerpunktpraxis fuer Diabetes, Gefaess- & Ernaehrungsmedizin, Falkensee, Not set
ClinPhenomics CVC GmbH, Frankfurt am Main, Not set
Diabeteszentrum Hamburg West, Hamburg, Not set
Endokrinologikum Hamburg, Hamburg, Not set
Diabetologische Schwerpunktpraxis Hohenmoelsen, Hohenmoelsen, Not set
Braun Ambulantes Herzzentrum Kassel, Kassel, Not set
Universitaetsklinikum Leipzig, Leipzig, Not set
AmBeNet GmbH, Leipzig, Not set
Universitaetsklinikum Schleswig-Holstein - Luebeck, Luebeck, Not set
Marienhaus Klinikum Mainz, Mainz, Not set
Kardiologische Praxis Doktor Jens Taggeselle, Markkleeberg, Not set
Centrum für Diagnostik und Gesundheit, Muenchen, Not set
Zentrum fuer Diabtes und Gefaesskrankheiten im Franziskus Carré Muenster, Muenster, Not set
Praxis Segner - Dr. Braun - Kirsch, Oberwuerzbach, Not set
Red-Institut GmbH, Oldenburg, Not set
Gemeinschaftspraxis Prof Jacob/ Dr Jacob, Villingen-Schwenningen, Not set
Zentrum fuer klinische Forschung Allgaeu Oberschwaben, Wangen IM Allgaeu, Not set
IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola, Bologna, Not set
Universita degli Studi Gabriele D Annunzio di Chieti e Pescara, Chieti, Not set
Azienda Ospedaliero Universitaria Careggi, Firenze, Not set
IRCCS Centro Cardiologico Monzino, Milano, Not set
Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco, Milano, Not set
Ospedale Civico, Di Cristina e Benfratelli, Palermo, Not set
Azienda Ospedaliero Universitaria Pisana, Pisa, Not set
Fondazione Policlinico Tor Vergata, Roma, Not set
Medical Corporation Hitomikai Motomachi Takatsuka Naika Clinic, Yokohama-shi, Kanagawa
Doujin Memorial Foundation, Meiwa Hospital, Chiyoda-ku, Tokyo
Tokyo Asbo Clinic, Chuo-ku, Tokyo
Medical Corp Seikoukai New Medical Research System Clinic, Hachioji-shi, Tokyo
Medical Corporation AOT Shinagawa Strings Clinic, Minato-ku, Tokyo
Clinical Research Hospital Tokyo, Shinjuku-ku, Tokyo
Medical Corporation Hanabusakai Shinei Medical Healthcare Clinic, Suginami-ku, Tokyo
Korea University Ansan Hospital, Ansan-si, Gyeonggi-do, Not set
Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Not set
The Catholic University of Korea Bucheon St Marys Hospital, Bucheon, Gyeonggi-do, Not set
Dong-A University Hospital, Busan, Not set
Kyungpook National University Hospital, Daegu, Not set
Yeungnam University Medical Center, Daegu, Not set
Daejeon Eulji Medical Center, Eulji University, DaeJeon, Not set
Konyang University Hospital, Daejeon, Not set
Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Not set
Seoul National University Hospital, Seoul, Not set
Kangbuk Samsung Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
KyungHee University Gangdong Hospital, Seoul, Not set
Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Not set
The Catholic University of Korea Yeouido St Marys Hospital, Seoul, Not set
Ajou University Hospital, Suwon-si Gyeonggi-do, Not set
Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnam-do, Not set
Gabinet Leczenia Otylosci i Chorob Dietozaleznych dr hab n med Lucyna Ostrowska, Bialystok, Not set
Kresmed Spolka z Ograniczona Odpowiedzialnoscia, Bialystok, Not set
Etg Lublin Spzoo, Debica, Not set
Futuremeds Spolka z ograniczona odpowiedzialnoscia, Gdynia, Not set
Uniwersyteckie Centrum Kliniczne im Prof K Gibinskiego Slaskiego UM w Katowicach, Katowice, Not set
Salvia-Lekston i Madej Spolka Jawna, Katowice, Not set
Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna, Lodz, Not set
Ekamed Spolka z Ograniczona Odpowiedzialnoscia, Lublin, Not set
Centrum Zdrowia Metabolicznego Pawel Bogdanski, Poznan, Not set
Clinical Research Center Spzoo Medic-R Spolka Komandytowa, Poznan, Not set
Futuremeds Spolka z ograniczona odpowiedzialnoscia, Warszawa, Not set
Clinical Best Solutions Sp zoo Spolka komandytowa, Warszawa, Not set
Ponce Medical School Foundation Inc, Ponce, Not set
Puerto Rico Medical Research Inc., Ponce, Not set
Latin Clinical Trial Center, San Juan, Not set
Wellness Clinical Research Vega Baja, Vega Baja, Not set
Centro Periferico de Especialidades Bola Azul, Almeria, Andalucía
Hospital Vithas Sevilla, Castilleja de la Cuesta, Andalucía
Hospital Infanta Elena, Huelva, Andalucía
Hospital Virgen del Camino, Sanlucar de Barrameda, Andalucía
Nuevas Tecnologias en Diabetes y Endocrinologia, Sevilla, Andalucía
Hospital Quironsalud Infanta Luisa, Sevilla, Andalucía
Hospital Medico Quirurgico San Rafael, A Coruña, Galicia
Clinica Ruber SA, Pozuelo de Alarcon, Madrid
Clinica Universidad de Navarra, Pamplona, Navarra
Clinica Juaneda, Palma, Not set
Hospital Universitario Doctor Peset, Valencia, Not set
Universitaetsspital Basel, Basel, Not set
Hopitaux Universitaires de Geneve, Geneve 14, Not set
Kantonsspital Sankt Gallen, Sankt Gallen, Not set
Stoffwechselzentrum Sankt Gallen, Sankt Gallen, Not set
Universitaetsspital Zuerich, Zuerich, Not set
Ormeau Clinical Trials Ltd, Belfast, Not set
FutureMeds Birmingham, Birmingham, Not set
Layton Medical Centre, Blackpool, Not set
Waterloo Medical Centre, Blackpool, Not set
Southmead Hospital, Bristol, Not set
The Rame Group Practice, Cornwall, Not set
Staploe Medical Centre, Ely, Not set
FutureMeds Glasgow, Glasgow, Not set
Hull Royal Infirmary, Hull, Not set
NIHR Leicestershire & Northamptonshire Commercial Research Delivery Centre, Leicester, Not set
Aintree University Hospital, Liverpool, Not set
FutureMeds Newcastle, Newcastle Upon Tyne, Not set
Atlantic Medical Group, Penzance, Not set
Clifton Medical Centre, Rotherham, Not set
Ashfields Primary Care Centre, Sandbach, Not set
Conditions: Obesity
Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
Recruiting
The primary objective of this study to evaluate efficacy of ravulizumab compared with placebo on proteinuria reduction and change in eGFR in adult participants with IgAN who are at risk of disease progression.
The primary objective of this study to evaluate efficacy of ravulizumab compared with placebo on proteinuria reduction and change in eGFR in adult participants with IgAN who are at risk of disease progression. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Research Site, Alabaster, Alabama +322 locations
Research Site, Alabaster, Alabama
Research Site, Phoenix, Arizona
Research Site, Los Angeles, California
Research Site, Los Angeles, California
Research Site, Los Angeles, California
Research Site, Orange, California
Research Site, San Bernardino, California
Research Site, San Diego, California
Research Site, San Francisco, California
Research Site, Stanford, California
Research Site, Torrance, California
Research Site, Valencia, California
Research Site, Aurora, Colorado
Research Site, Bay Pines, Florida
Research Site, Miami, Florida
Research Site, Orlando, Florida
Research Site, Acworth, Georgia
Research Site, Atlanta, Georgia
Research Site, Lawrenceville, Georgia
Research Site, Meridian, Idaho
Research Site, Iowa City, Iowa
Research Site, New Orleans, Louisiana
Research Site, Shreveport, Louisiana
Research Site, Augusta, Maine
Research Site, Boston, Massachusetts
Research Site, Boston, Massachusetts
Research Site, Boston, Massachusetts
Research Site, Worcester, Massachusetts
Research Site, Pontiac, Michigan
Research Site, Minneapolis, Minnesota
Research Site, Minneapolis, Minnesota
Research Site, Kansas City, Missouri
Research Site, Saint Peters, Missouri
Research Site, North Las Vegas, Nevada
Research Site, Albany, New York
Research Site, Bronx, New York
Research Site, East Setauket, New York
Research Site, New York, New York
Research Site, Columbus, Ohio
Research Site, Charleston, South Carolina
Research Site, Knoxville, Tennessee
Research Site, Arlington, Texas
Research Site, Houston, Texas
Research Site, Houston, Texas
Research Site, San Antonio, Texas
Research Site, Shenandoah, Texas
Research Site, Temple, Texas
Research Site, Charlottesville, Virginia
Research Site, Milwaukee, Wisconsin
Research Site, Buenos Aires, Not set
Research Site, Ciudad de Buenos Aires, Not set
Research Site, Córdoba, Not set
Research Site, Florencio Varela, Not set
Research Site, La Plata, Not set
Research Site, Rosario, Not set
Research Site, San Luis, Not set
Research Site, Camperdown, Not set
Research Site, Canberra, Not set
Research Site, Clayton, Not set
Research Site, Concord, Not set
Research Site, Herston, Not set
Research Site, Liverpool, Not set
Research Site, Parkville, Not set
Research Site, Perth, Not set
Research Site, Southport, Not set
Research Site, St Albans, Not set
Research Site, Graz, Not set
Research Site, Innsbruck, Not set
Research Site, Linz, Not set
Research Site, Brussel, Not set
Research Site, Edegem, Not set
Research Site, Leuven, Not set
Research Site, Liège, Not set
Research Site, Roeselare, Not set
Research Site, Belo Horizonte, Not set
Research Site, Belo Horizonte, Not set
Research Site, Belo Horizonte, Not set
Research Site, Botucatu, Not set
Research Site, Curitiba, Not set
Research Site, Fortaleza, Not set
Research Site, Recife, Not set
Research Site, Ribeirão Preto, Not set
Research Site, Salvador, Not set
Research Site, São José do Rio Preto, Not set
Research Site, São Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Winnipeg, Manitoba
Research Site, London, Ontario
Research Site, Ottawa, Ontario
Research Site, Toronto, Ontario
Research Site, Araucania, Not set
Research Site, Providencia, Not set
Research Site, Santiago, Not set
Research Site, Santiago, Not set
Research Site, Valdivia, Not set
Research Site, Baotou, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changsha, Not set
Research Site, Changzhou, Not set
Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Jinan, Not set
Research Site, Jinan, Not set
Research Site, Jinhua, Not set
Research Site, Lanzhou, Not set
Research Site, Luoyang, Not set
Research Site, Nanchang, Not set
Research Site, Nanchang, Not set
Research Site, Nanjing, Not set
Research Site, Nanjing, Not set
Research Site, Nanjing, Not set
Research Site, Ningbo, Not set
Research Site, Qingdao, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Shenzhen, Not set
Research Site, Shenzhen, Not set
Research Site, Urumqi, Not set
Research Site, Wuhan, Not set
Research Site, Wuxi, Not set
Research Site, Xian, Not set
Research Site, Yantai, Not set
Research Site, Yibin, Not set
Research Site, Yinchuan, Not set
Research Site, Zhanjiang, Not set
Research Site, Zhengzhou, Not set
Research Site, Zhongshan, Not set
Research Site, Barranquilla, Not set
Research Site, Bogota, Not set
Research Site, Cali, Not set
Research Site, Manizales, Not set
Research Site, Medellín, Not set
Research Site, Rionegro, Not set
Research Site, Nový Jičín, Not set
Research Site, Praha, Not set
Research Site, Praha, Not set
Research Site, Amiens, Not set
Research Site, Bayonne, Not set
Research Site, Brest Cedex, Not set
Research Site, Chambéry, Not set
Research Site, Clermont-Ferrand, Not set
Research Site, Le Kremlin-Bicêtre, Not set
Research Site, Marseille, Not set
Research Site, Nantes, Not set
Research Site, Nice, Not set
Research Site, Paris, Not set
Research Site, Paris, Not set
Research Site, Paris, Not set
Research Site, Saint-Priest-en-Jarez, Not set
Research Site, Strasbourg, Not set
Research Site, Toulouse, Not set
Research Site, Aachen, Not set
Research Site, Berlin, Not set
Research Site, Erlangen, Not set
Research Site, Essen, Not set
Research Site, Greifswald, Not set
Research Site, Hannover, Not set
Research Site, Konstanz, Not set
Research Site, Köln, Not set
Research Site, Mainz, Not set
Research Site, München, Not set
Research Site, München, Not set
Research Site, Villingen-Schwenningen, Not set
Research Site, Athens, Not set
Research Site, Athens, Not set
Research Site, Heraclion, Not set
Research Site, Patras, Not set
Research Site, Thessaloniki, Not set
Research Site, HKG, Not set
Research Site, Hong Kong, Not set
Research Site, Hong Kong, Not set
Research Site, Lai Chi Kok, Not set
Research Site, Budapest, Not set
Research Site, Miskolc, Not set
Research Site, Haifa, Not set
Research Site, Jerusalem, Not set
Research Site, Nazareth, Not set
Research Site, Petah Tikva, Not set
Research Site, Tel Aviv, Not set
Research Site, Agrigento, Not set
Research Site, Bari, Not set
Research Site, Bologna, Not set
Research Site, Brescia, Not set
Research Site, Cagliari, Not set
Research Site, Firenze, Not set
Research Site, Milano, Not set
Research Site, Milano, Not set
Research Site, Padova, Not set
Research Site, Parma, Not set
Research Site, Piacenza, Not set
Research Site, Torino, Not set
Research Site, Torrette, Not set
Research Site, Verona, Not set
Research Site, Ashikaga, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Chiba-shi, Not set
Research Site, Chiba-shi, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Kamakura, Not set
Research Site, Kasugai-shi, Not set
Research Site, Kitakyushu-shi, Not set
Research Site, Kobe-shi, Not set
Research Site, Matsumoto-shi, Not set
Research Site, Matsuyama-shi, Not set
Research Site, Nagoya, Not set
Research Site, Osaka-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Sapporo-shi, Not set
Research Site, Toyota-Shi, Not set
Research Site, Urayasu-shi, Not set
Research Site, Anyang-si, Not set
Research Site, Busan, Not set
Research Site, Deagu, Not set
Research Site, Gwangju, Not set
Research Site, Gyeonggi-do, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon-si, Not set
Research Site, Ipoh, Not set
Research Site, Johor Bahru, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Seremban, Not set
Research Site, Taiping, Not set
Research Site, Chihuahua, Not set
Research Site, Culiacan, Not set
Research Site, Guadalajara, Not set
Research Site, Juriquilla, Not set
Research Site, Mexico, Not set
Research Site, Zapopan, Not set
Research Site, Amsterdam, Not set
Research Site, Groningen, Not set
Research Site, Nijmegen, Not set
Research Site, Rotterdam, Not set
Research Site, Białystok, Not set
Research Site, Białystok, Not set
Research Site, Kraków, Not set
Research Site, Lublin, Not set
Research Site, Olsztyn, Not set
Research Site, Poznań, Not set
Research Site, Szczecin, Not set
Research Site, Warszawa, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, Braga, Not set
Research Site, Funchal, Not set
Research Site, Lisbon, Not set
Research Site, Porto, Not set
Research Site, Torres Novas, Not set
Research Site, Bucureşti, Not set
Research Site, Cluj Napoca, Not set
Research Site, Timisoara, Not set
Research Site, Dammam, Not set
Research Site, Jeddah, Not set
Research Site, Riyadh, Not set
Research Site, Riyadh, Not set
Research Site, Riyadh, Not set
Research Site, Riyadh, Not set
Research Site, Banská Bystrica, Not set
Research Site, Bratislava, Not set
Research Site, Košice, Not set
Research Site, Martin, Not set
Research Site, A Coruña, Not set
Research Site, Alcalá de Henares, Not set
Research Site, Lérida, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Murcia, Not set
Research Site, Málaga, Not set
Research Site, Oviedo, Not set
Research Site, Sant Joan Despí, Not set
Research Site, Sevilla, Not set
Research Site, Tarragona, Not set
Research Site, Valencia, Not set
Research Site, Zaragoza, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, New Taipei City, Not set
Research Site, New Taipei, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Tainan City, Not set
Research Site, Taipei, Not set
Research Site, Taoyuan, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Bangkok, Not set
Research Site, Chaingmai, Not set
Research Site, Khlong Luang, Not set
Research Site, Khon Kaen, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Bursa, Not set
Research Site, İstanbul, Not set
Research Site, İstanbul, Not set
Research Site, Kahramanmaras, Not set
Research Site, Kayseri, Not set
Research Site, Kocaeli, Not set
Research Site, Konya, Not set
Research Site, Pamukkale, Not set
Research Site, Cambridge, Not set
Research Site, Doncaster, Not set
Research Site, Dundee, Not set
Research Site, Leicester, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Reading, Not set
Research Site, Salford, Not set
Research Site, Stevenage, Not set
Conditions: Immunoglobulin A Nephropathy, IgAN
A Phase 3, Placebo-controlled, Double-blind Study Assessing Rocatinlimab in Prurigo Nodularis
Recruiting
The main objective of the study will be to evaluate the efficacy of rocatinlimab compared with placebo at week 24 on the patient-reported outcome (PRO) measure of pruritus and overall clinical assessment score (US only).
The main objective of the study will be to evaluate the efficacy of rocatinlimab compared with placebo at week 24 on the patient-reported outcome (PRO) measure of pruritus and overall clinical assessment score (US only). Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/13/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +191 locations
University of Alabama at Birmingham, Birmingham, Alabama
First OC Dermatology, Fountain Valley, California
Los Angeles Universal Research Center, Los Angeles, California
Paradigm Clinical Research Center Inc, San Diego, California
Wolverine Clinical Trials, Santa Ana, California
Direct Helpers Research Center, Hialeah, Florida
Wellness Clinical Research, Miami Lakes, Florida
Southern Clinical Research, Miami, Florida
University of Miami Hospital, Miami, Florida
Miami Dermatology and Laser Institute, Miami, Florida
Clinical Research Trials of Florida Inc, Tampa, Florida
Olympian Clinical Research - Tampa, Tampa, Florida
Emory University, Atlanta, Georgia
Endeavor Health Clinical Trials Center, Skokie, Illinois
The Indiana Clinical Trials Center PC, Plainfield, Indiana
Revival Research Institute, LLC, Troy, Michigan
Icahn School of Medicine at Mount Sinai, New York, New York
Optima Research, Boardman, Ohio
University Hospitals Cleveland Medical Center, Cleveland, Ohio
Wright State Physicians, Fairborn, Ohio
Hightower Clinical, Oklahoma City, Oklahoma
Center For Clinical Studies PLLC, Houston, Texas
Clarity Dermatology, Lancaster, Texas
Springville Dermatology, Springville, Utah
Hospital Universitario Austral, Derqui, Pilar, Buenos Aires
Instituto de Investigaciones Clinicas de Cordoba, Cordoba, Córdoba
Instituto de Neumonologia y Dermatologia, Ciudad Autonoma de Buenos Aires, Distrito Federal
Derma Internacional, Ciudad Autonoma de Buenos Aires, Distrito Federal
Centro de investigacion clinica y epidemiologica, San Miguel D Tucuman, Tucuman
Parra Dermatologia, Mendoza, Not set
St George Dermatology and Skin Cancer Centre, Kogarah, New South Wales
Veracity Clinical Research, Woolloongabba, Queensland
Box Hill Hospital, Box Hill, Victoria
The Alfred Hospital, Melbourne, Victoria
The Royal Melbourne Hospital, Parkville, Victoria
Medizinische Universitaet Graz, Graz, Not set
Ordensklinikum Linz Elisabethinen, Linz, Not set
Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Bruxelles, Not set
Universitaire Ziekenhuizen Leuven Gasthuisberg, Leuven, Not set
Centre Hospitalier Universitaire de Liege - Sart Tilman, Liege, Not set
Clinica Instituto Bahiano de Imunoterapia - Medicina, Reumatologia e Dermatologia ltda, Salvador, Bahia
Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande Do Sul
Universidade Estadual Paulista Julio de Mesquita Filho, Botucatu, São Paulo
Fundacao Abc - Centro Univ Fmabc, Santo Andre, São Paulo
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, São Paulo
IBPClin Instituto Brasil de Pesquisa Clinica, Rio de Janeiro, Not set
Doctor Chih-Ho Hong Medical Incorporated, Surrey, British Columbia
Skincare Studio, St. John's, Newfoundland and Labrador
CCA Medical Research Corp, Ajax, Ontario
Centricity Research London Victoria, London, Ontario
Lovegrove Dermatology, London, Ontario
Lynderm Research Inc, Markham, Ontario
SKiN Centre for Dermatology, Peterborough, Ontario
York Dermatology Clinic and Research Centre, Richmond Hill, Ontario
Toronto Research Centre Inc, Toronto, Ontario
AvantDerm, Toronto, Ontario
Alliance Clinical Trials, Waterloo, Ontario
Centre de Recherche Dermatologique du Quebec Metropolitain, Quebec, Not set
Enroll SpA, Providencia, Santiago
Centro Medico Skinmed Spa, Santiago, Not set
Fundacion Innovacion Cardiovascular Clinica Ensenada, Santiago, Not set
Centro Internacional de Estudios Clinicos, Santiago, Not set
Clinical Research Chile SpA, Valdivia, Not set
Peking University First Hospital, Beijing, Beijing
Peking University Third Hospital, Beijing, Beijing
The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian
The First Affiliated Hospital Sun-Yat Sen University, Guangzhou, Guangdong
Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong
Nanfang Hospital Southern Medical University, Guangzhou, Guangdong
The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi
Sanmenxia Central Hospital, Sanmenxia, Henan
The Second Xiangya Hospital of Central South University, Changsha, Hunan
Wuxi Peoples Hospital, Wuxi, Jiangsu
Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi
The First Bethune Hospital of Jilin University, Changchun, Jilin
The Second Affiliated Hospital Of Xi An Jiaotong University, XI An, Shaanxi
Huashan Hospital Affiliated to Fudan University, Shanghai, Shanghai
Shanghai Skin Disease Hospital, Shanghai, Shanghai
Chengdu Second Peoples Hospital, Chengdu, Sichuan
West China Hospital of Sichuan University, Chengdu, Sichuan
Tianjin Medical University General Hospital, Tianjin, Tianjin
The Second Affliated Hospital of Kunming Medical University, Kunming, Yunnan
Affiliated Hangzhou First Peoples Hospital School of Medicine Westlake University, Hangzhou, Zhejiang
Clinical Research Services Helsinki, Helsinki, Not set
Oulun Yliopistollinen sairaala, Oulu, Not set
Terveystalo Tampere, Tampere, Not set
Centre Hospitalier Regional Universitaire de Brest - Hopital Morvan, Brest, Not set
Centre Hospitalier Le Mans, Le Mans Cedex 9, Not set
Cabinet du Docteur Ruer-Mulard Mireille, Martigues, Not set
Centre Hospitalier Universitaire Archet 2, Nice, Not set
Centre Hospitalier Universitaire de Rouen - Hopital Charles Nicolle, Rouen Cedex, Not set
Universitaetsklinikum Augsburg, Augsburg, Not set
Fachklinik Bad Bentheim, Bad Bentheim, Not set
Charite - Universitaetsmedizin Berlin, Campus Virchow, Berlin, Not set
Rosenpark Research GmbH, Darmstadt, Not set
Universitaetsklinikum Dresden, Dresden, Not set
Universitaetsklinikum Schleswig-Holstein - Kiel, Kiel, Not set
Universitaetsmedizin Mainz, Mainz, Not set
Universitaetsklinikum Muenster, Muenster, Not set
Hautarztpraxis Mortazawi, Remscheid, Not set
Universitaetsklinikum Tuebingen, Tuebingen, Not set
Helios Klinikum Wuppertal, Wuppertal, Not set
University General Hospital Attikon, Athens, Not set
Andreas Syngros Hospital Of Venereal And Dermatological Diseases, Athens, Not set
General Hospital Of Nea Ionia Konstantopouleio Patision, Nea Ionia, Not set
Ippokratio General Hospital of Thessaloniki, Thessaloniki, Not set
Papageorgiou General Hospital, Thessaloniki, Not set
Queen Mary Hospital, The University of Hong Kong, Hong Kong, Not set
Obudai Egeszsegugyi Centrum Kft, Budapest, Not set
Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set
Derm-Surg Kft, Kaposvar, Not set
DermaMed Research Kft, Oroshaza, Not set
Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar, Szeged, Not set
Ospedale San Salvatore, LAquila, Not set
Azienda Ospedaliera Luigi Sacco, Milano, Not set
Azienda Ospedaliero Universitaria di Modena, Modena, Not set
Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia, Perugia, Not set
Fondazione Policlinico Tor Vergata, Roma, Not set
Fujita Health University Hospital, Toyoake-shi, Aichi
Ogaki Municipal Hospital, Ogaki-shi, Gifu
Medical Corporation Kojinkai Sapporo Skin Clinic, Sapporo-shi, Hokkaido
Mito Kyodo General Hospital, Mito-shi, Ibaraki
Kochi Medical School Hospital, Nankoku-shi, Kochi
Noguchi Dermatology Clinic, Kamimashiki-gun, Kumamoto
Nagasaki University Hospital, Nagasaki-shi, Nagasaki
Kawasaki Medical School Hospital, Kurashiki-shi, Okayama
Hayami Dermatology Clinic, Osaka-shi, Osaka
Dokkyo Medical University Saitama Medical Center, Koshigaya-shi, Saitama
National Defense Medical College hospital, Tokorozawa-shi, Saitama
Institute of Science Tokyo Hospital, Bunkyo-ku, Tokyo
Tokyo Teishin Hospital, Chiyoda-ku, Tokyo
Shirasaki Dermatology Clinic, Takaoka-shi, Toyama
Tokyo Medical University Hospital, Shinjyuku-ku, Not set
Korea University Ansan Hospital, Ansansi, Gyeonggido, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Hanyang University Seoul Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Hallym University Kangnam Sacred Heart Hospital, Seoul, Not set
J Kisis, Riga, Not set
Outpatient clinic Veselibas Centrs 4, Riga, Not set
Outpatient clinic Veselibascentrs 4, Riga, Not set
Clínica de Enfermedades Crónicas y de Procedimientos Especiales, Morelia, Michoacán
Instituto de Investigaciones Aplicadas a la Neurociencia A C, Durango, Not set
Universitair Medisch Centrum Utrecht, Utrecht, Not set
Niepubliczny Zaklad Opieki Zdrowotnej, Bialystok, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
AKK Medical Spolka z ograniczona odpowiedzialnoscia Centrum Medyczne Tu sie leczy, Gdansk, Not set
GynCentrum Spzoo NZOZ Holsamed - Oddzial Libero, Katowice, Not set
Amicare Spolka z ograniczona odpowiedzialnoscia Spolka Komandytowa Amicare Centrum Medyczne, Lodz, Not set
Dermedic Jacek Zdybski, Ostrowiec Swietokrzyski, Not set
Uniwersytecki Szpital Kliniczny imienia Fryderyka Chopina w Rzeszowie, Rzeszow, Not set
Velocity Skierniewice Spolka z Ograniczona Odpowiedzialnoscia, Skierniewice, Not set
Centrum Zdrowia Dziecka i Rodziny Im Jana Pawla II w Sosnowcu Osrodek Badan Klinicznych, Sosnowiec, Not set
Royalderm Agnieszka Nawrocka, Warszawa, Not set
Cityclinic Przychodnia Lekarsko Psychologiczna Matusiak Spolka Partnerska, Wroclaw, Not set
DermMedica Spzoo Centrum Columbus, Wroclaw, Not set
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria, Lisboa, Not set
Hospital Cuf Descobertas, Lisboa, Not set
Unidade Local de Saude de Santo Antonio, EPE - Hospital de Santo Antonio, Porto, Not set
Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Cluj-Napoca, Not set
Spitalul Clinic Judetean Mures, Targu Mures, Not set
Hospital Universitario Reina Sofia, Cordoba, Andalucía
Hospital Universitario Miguel Servet, Zaragoza, Aragón
Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Canarias
Hospital Universitari Germans Trias i Pujol, Badalona, Cataluña
Hospital de la Santa Creu i Sant Pau, Barcelona, Cataluña
Hospital General Universitario de Alicante, Alicante, Comunidad Valenciana
Hospital Universitario de La Princesa, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Diagnostiskt Centrum Hud i Sickla, Nacka, Not set
Akademiska sjukhuset, Uppsala, Not set
Inselspital Bern, Bern, Not set
Universitaetsspital Zuerich, Zuerich Flughafen, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
National Taiwan University Hospital, Taipei, Not set
Mackay Memorial Hospital Taipei Branch, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital, Taoyuan, Not set
Ankara Bilkent Sehir Hastanesi, Ankara, Not set
Adnan Menderes Universitesi Medical Faculty, Aydin, Not set
Pamukkale Universitesi Tip Fakultesi Hastanesi, Denizli, Not set
Gaziantep Universitesi Tip Fakultesi Hastanesi, Gaziantep, Not set
Izmir Demokrasi Universitesi Buca Seyfi Demirsoy Egitim ve Arastirma Hastanesi, Izmir, Not set
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi, Samsun, Not set
Queen Elizabeth University Hospital, Glasgow, Not set
Chapel Allerton Hospital, Leeds, Not set
Royal London Hospital, London, Not set
Guys Hospital, London, Not set
Ameli-Biogroup Limited, Waltham Abbey, Not set
Conditions: Prurigo Nodularis
Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)
Recruiting
The primary objective of the study is to compare sacituzumab tirumotecan combined with pembrolizumab to pembrolizumab alone with respect to overall survival (OS). The primary hypothesis is that the combination of sacituzumab tirumotecan and pembrolizumab is superior to pembrolizumab alone with respect to OS.
All participants who have completed the first course of pembrolizumab may be eligible for up to an additional 9 cycles of pembrolizumab monotherapy if there is blinded independent central r... Read More
The primary objective of the study is to compare sacituzumab tirumotecan combined with pembrolizumab to pembrolizumab alone with respect to overall survival (OS). The primary hypothesis is that the combination of sacituzumab tirumotecan and pembrolizumab is superior to pembrolizumab alone with respect to OS.
All participants who have completed the first course of pembrolizumab may be eligible for up to an additional 9 cycles of pembrolizumab monotherapy if there is blinded independent central review (BICR)-verified progressive disease by Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1) after initial treatment. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0130), Burbank, California +206 locations
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0130), Burbank, California
Cancer Centers of Colorado St. Mary's Regional Hospital ( Site 0132), Grand Junction, Colorado
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0106), Marietta, Georgia
The University of Louisville, James Graham Brown Cancer Center ( Site 0121), Louisville, Kentucky
New England Cancer Specialists ( Site 0143), Westbrook, Maine
University of Massachusetts Chan Medical School-Division of Hematology/Oncology ( Site 0144), Worcester, Massachusetts
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0115), Minneapolis, Minnesota
Hattiesburg Clinic Hematology/Oncology ( Site 0104), Hattiesburg, Mississippi
Renown Regional Medical Center-Renown Health Medical Oncology ( Site 0134), Reno, Nevada
University Hospitals Cleveland Medical Center ( Site 0119), Cleveland, Ohio
Good Samaritan Regional Medical Center-Samaritan Pastega Regional Cancer Center ( Site 0117), Corvallis, Oregon
Oncology Consultants P.A. ( Site 0129), Houston, Texas
Instituto Alexander Fleming ( Site 0306), Ciudad Autónoma de Buenos Aires, Buenos Aires
Hospital Británico de Buenos Aires-Oncology ( Site 0304), Ciudad autónoma de Buenos Aires, Caba
Centro Privado de RMI Río Cuarto S.A. II ( Site 0310), Río Cuarto, Cordoba
Instituto de Oncología de Rosario ( Site 0301), Rosario, Santa Fe
Hospital Aleman-Oncology ( Site 0300), Buenos Aires, Not set
Port Macquarie - Mid North Coast Cancer Institute-Medical Oncology ( Site 3002), Port Macquarie, New South Wales
Westmead Hospital ( Site 3000), Westmead, New South Wales
Grampians Health-Medical Oncology ( Site 3001), Ballarat Central, Victoria
Northern Hospital ( Site 3003), Epping, Victoria
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0409), Porto Alegre, Rio Grande Do Sul
Clinica Viver ( Site 0400), Santa Maria, Rio Grande Do Sul
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0402), Barretos, Sao Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0406), São José do Rio Preto, Sao Paulo
Instituto Nacional de Câncer - INCA ( Site 0405), Rio de Janeiro, Not set
Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 0401), Sao Paulo, Not set
William Osler Health System ( Site 0203), Brampton, Ontario
Trillium Health Partners - Credit Valley Hospital ( Site 0202), Mississauga, Ontario
McGill University Health Centre ( Site 0200), Montréal, Quebec
Clinica Universidad Catolica del Maule-Oncology ( Site 0501), Talca, Maule
Bradfordhill-Clinical Area ( Site 0507), Santiago., Region M. De Santiago
Orlandi Oncologia-Oncology ( Site 0504), Santiago, Region M. De Santiago
FALP-UIDO ( Site 0509), Santiago, Region M. De Santiago
Bradford Hill Norte ( Site 0516), Antofagasta, Not set
Second Affiliated hospital of Anhui Medical University ( Site 3133), Hefei, Anhui
Beijing Cancer hospital-intrathoratic deparmtment II ( Site 3101), Beijing, Beijing
Beijing Peking Union Medical College Hospital-pneumology department ( Site 3100), Beijing, Beijing
Fujian Provincial Cancer Hospital ( Site 3131), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University-Breast Surgery ( Site 3107), Xiamen, Fujian
The First Affiliated Hospital of Guangzhou Medical University ( Site 3134), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 3108), Guangzhou, Guangdong
Affiliated Hospital of Guangdong Medical University ( Site 3123), Zhanjiang, Guangdong
The Second Hospital of Hebei Medical University ( Site 3135), Shijiazhuang, Hebei
Harbin Medical University Cancer Hospital-oncology of department ( Site 3132), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 3116), Zhengzhou, Henan
Tongji Hospital Tongji Medical,Science & Technology ( Site 3117), Wuhan, Hubei
Wuhan Union Hospital ( Site 3130), Wuhan, Hubei
Hubei Cancer Hospital ( Site 3106), Wuhan, Hubei
Xiangyang Central Hospital-oncology department ( Site 3136), Xiangyang, Hubei
The Second Xiangya Hospital of Central South University ( Site 3138), Changsha, Hunan
Affiliated Hospital of Jiangnan University(Wuxi Fourth People's Hospital ) ( Site 3113), Wuxi, Jiangsu
The Affiliated Hospital of Xuzhou Medical College ( Site 3112), Xuzhou, Jiangsu
The First Affiliated Hospital of Nanchang University-Respiratory Medicine Department ( Site 3127), Nanchang, Jiangxi
The Second Affiliated Hospital of Nanchang University-Oncology Department ( Site 3121), Nanchang, Jiangxi
Jiangxi Provincial Cancer Hospital ( Site 3143), Nanchang, Jiangxi
Jilin Province Tumor Hospital-oncology department ( Site 3126), Changchun, Jilin
Jinan Central Hospital-oncology department ( Site 3122), Jinan, Shandong
Shandong Cancer Hospital ( Site 3119), Jinan, Shandong
Shanghai Changhai Hospital ( Site 3125), Shanghai, Shanghai
West China Hospital, Sichuan University ( Site 3124), Cheng Du, Sichuan
Sichuan Cancer hospital. ( Site 3105), Chengdu, Sichuan
The Second People's Hospital of Neijiang ( Site 3140), Neijiang, Sichuan
Yunnan Province Cancer Hospital ( Site 3139), Kunming, Yunnan
The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3115), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 3111), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province-Respiratory ( Site 3114), Taizhou, Zhejiang
IMAT S.A.S ( Site 0602), Monteria, Cordoba
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0600), Bogota, Distrito Capital De Bogota
Oncologos del Occidente ( Site 0603), Pereira., Risaralda
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 1103), Ostrava, Ostrava Mesto
Multiscan-Onkologicke a radiologicke centrum Multiscan Pardubice ( Site 1105), Pardubice, Pardubicky Kraj
Vseobecna fakultni nemocnice v Praze-Onkologicka klinika ( Site 1106), Praha, Praha 2
Fakultni nemocnice Olomouc-Klinika plicnich nemoci a tuberkulozy ( Site 1102), Olomouc, Not set
Regionshospitalet Gødstrup-Kræftklinikken ( Site 1204), Herning, Midtjylland
Aalborg Universitetshospital, Syd-Department of Oncology ( Site 1201), Aalborg, Nordjylland
Odense Universitetshospital ( Site 1200), Odense C, Syddanmark
Hôpital Saint Joseph-ONCOLOGY ( Site 1308), Marseille, Bouches-du-Rhone
Institut Régional du Cancer Montpellier-Medical Oncology ( Site 1309), Montpellier, Herault
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuyt-Unité d'oncologie thoracique et cutané ( Site 1303), Limoges, Limousin
Centre d'Oncologie de Gentilly ( Site 1301), Nancy, Meurthe-et-Moselle
Centre Hospitalier de la Côte Basque ( Site 1300), Bayonne, Pyrenees-Atlantiques
L HOPITAL NORD OUEST ( Site 1310), Gleize, Rhone
Clinique de l'Europe-Service de pneumologie ( Site 1304), Amiens, Somme
Centre Hospitalier Universitaire de Poitiers-Pôle régional de cancérologie ( Site 1305), Poitiers, Vienne
Klinikum der Ludwig-Maximilians-Universitaet Muenchen-Medizinische Klinik V ( Site 1409), München, Bayern
Klinikum Bogenhausen-Klinik für Pneumologie und Onkologische Pneumologie ( Site 1406), München, Bayern
Klinikum Nürnberg Nord-5. Med. Klinik ( Site 1407), Nuremberg, Bayern
Universitätsklinikum Marburg-Comprehensive Cancer Center ( Site 1412), Marburg, Hessen
Medizinische Hochschule Hannover-Department of Pneumology ( Site 1411), Hannover, Niedersachsen
Bethanien Krankenhaus Moers ( Site 1400), Moers, Nordrhein-Westfalen
Universitätsklinikum Münster - Albert Schweitzer Campus-Medizinische Klinik A ( Site 1410), Münster, Nordrhein-Westfalen
Universitätsmedizin Johannes Gutenberg Universität Mainz-3. Medizinische Klinik und Poliklinik ( Site 1404), Mainz, Rheinland-Pfalz
LungenClinic Grosshansdorf-Onkologie ( Site 1401), Grosshansdorf, Schleswig-Holstein
SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1403), Gera, Thuringen
Charité Campus Virchow-Klinikum-Department of Infectious Diseases and Pulmonary Medicine ( Site 1402), Berlin, Not set
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 1807), Meldola, Emilia-Romagna
P.O. "S. Maria della Misericordia" Azienda Sanitaria Univers-Oncology Department ( Site 1803), Udine, Friuli-Venezia Giulia
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1800), Milan, Lombardia
Instituto Tumori Giovanni Paolo II-SSD Oncologia Medica per la Patologia Toracica ( Site 1804), Bari, Puglia
AOU Renato Dulbecco ( Site 1801), Catanzaro, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1806), Roma, Not set
Fujita Health University Hospital ( Site 3411), Toyoake, Aichi
Hirosaki University Hospital ( Site 3429), Hirosaki, Aomori
National Cancer Center Hospital East ( Site 3403), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 3415), Matsuyama, Ehime
National Hospital Organization Kyushu Cancer Center ( Site 3417), Fukuoka,, Fukuoka
Kurume University Hospital ( Site 3418), Kurume, Fukuoka
Gunma Prefectural Cancer Center ( Site 3402), Ota, Gunma
National Hospital Organization Himeji Medical Center ( Site 3426), Himeji, Hyogo
Iwate Medical University Hospital ( Site 3428), Shiwa-gun, Iwate
St. Marianna University Hospital ( Site 3421), Kawasaki, Kanagawa
Yokohama Municipal Citizen's Hospital ( Site 3425), Yokohama, Kanagawa
Kanagawa Cancer Center ( Site 3408), Yokohama, Kanagawa
Matsusaka Municipal Hospital ( Site 3422), Matsusaka, Mie
Tohoku University Hospital ( Site 3424), Sendai, Miyagi
Sendai Kousei Hospital ( Site 3400), Sendai, Miyagi
Kansai Medical University Hospital ( Site 3412), Hirakata, Osaka
Osaka Medical and Pharmaceutical University Hospital ( Site 3413), Takatsuki, Osaka
National Hospital Organization Ureshino Medical Center ( Site 3427), Ureshino, Saga
Niigata Cancer Center Hospital ( Site 3409), Niigata, Saitama
Shizuoka Cancer Center ( Site 3410), Suntogun, Shizuoka
Dokkyo Medical University Hospital ( Site 3401), Shimotsugagun, Tochigi
Tokyo Metropolitan Komagome Hospital ( Site 3405), Bunkyo, Tokyo
Cancer Institute Hospital of JFCR ( Site 3404), Koto, Tokyo
Toho University Omori Medical Center ( Site 3420), Ota, Tokyo
Tokyo Medical University Hospital ( Site 3407), Shinjuku, Tokyo
National Center for Global Health and Medicine ( Site 3406), Shinjuku, Tokyo
National Hospital Organization Yamaguchi Ube Medical Center ( Site 3423), Ube, Yamaguchi
National Hospital Organization Kyushu Medical Center ( Site 3416), Fukuoka, Not set
Saiseikai Kumamoto Hospital ( Site 3419), Kumamoto, Not set
Osaka International Cancer Institute ( Site 3414), Osaka, Not set
Chungbuk National University Hospital-Internal medicine ( Site 3804), Cheongju-si, Chungbuk
Wonju Severance Christian Hospital ( Site 3808), Wonju, Kang-won-do
National Cancer Center ( Site 3801), Goyang-si, Kyonggi-do
The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 3800), Suwon-si, Kyonggi-do
Ajou University Hospital-Hematology-Oncology ( Site 3806), Suwon-si, Kyonggi-do
Keimyung University Dongsan Hospital CRC room 1 ( Site 3807), Daegu, Taegu-Kwangyokshi
Asan Medical Center-Lung Cancer Center ( Site 3805), Seoul, Not set
Samsung Medical Center-Division of Hematology/Oncology ( Site 3802), Seoul, Not set
Higiea Oncologia ( Site 0721), Mexico City, Distrito Federal
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0715), Guadalajara, Jalisco
Axis Heilsa S. de R.L. de C.V. ( Site 0719), Monterrey, Nuevo Leon
Centro de Atención e Investigación Cardiovascular del Potosí ( Site 0713), San Luis Potosí, San Luis Potosi
Oaxaca Site Management Organization S.C. ( Site 0718), Oaxaca, Not set
Clinica Integral Internacional de Oncología ( Site 0714), Puebla, Not set
Amphia Ziekenhuis, locatie Breda Molengracht-long oncologie ( Site 1901), Breda, Noord-Brabant
ETZ Elisabeth-Department of Pulmonary Diseases ( Site 1902), Tilburg, Noord-Brabant
Isala, locatie Zwolle-Poli Longziekten ( Site 1903), Zwolle, Overijssel
Clinica Vallesur - AUNA ( Site 0854), Arequipa, Ariqipa
Detecta Clínica ( Site 0853), Surquillo, Muni Metro De Lima
IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 0851), Lima, Not set
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 0850), Lima, Not set
Hospital Cayetano Heredia-Oncology ( Site 0855), Lima, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2003), Bydgoszcz, Kujawsko-pomorskie
Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 2013), Grudziadz, Kujawsko-pomorskie
Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu ( Site 2016), Torun, Kujawsko-pomorskie
SPZOZ Uniwersytecki Szpital Kliniczny Im. Wojskowej Akademii Medycznej UM W Łodzi Centralny Szpital ( Site 2012), Łódź, Lodzkie
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 2015), Kraków, Malopolskie
Instytut Gruźlicy i Chorób Płuc w Warszawie-3rd Dep of Lung Diseases and Oncology ( Site 2011), Warszawa, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2000), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2001), Przemysl, Podkarpackie
Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 2104), Lisbon, Lisboa
Unidade Local de Saude de Santa Maria - Hospital Pulido Valente ( Site 2101), Lisbon, Lisboa
Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 2103), Vila Nova de Gaia, Porto
Hospital Dr. Nélio Mendonça ( Site 2105), Funchal, Regiao Autonoma Da Madeira
Hospital CUF - Tejo ( Site 2100), Lisboa, Not set
Hospital Jerez de la Frontera-UGC Oncología ( Site 2333), Jerez de la Frontera, Cadiz
CHUAC-Hospital Teresa Herrera-MEDICAL ONCOLOGY ( Site 2335), A Coruña, La Coruna
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2331), Pozuelo de Alarcon, Madrid
H.R.U Malaga - Hospital General ( Site 2332), Málaga, Malaga
Fundación Instituto Valenciano de Oncología-Oncologico ( Site 2336), Valencia, Valenciana, Comunitat
Hospital Universitari Vall d'Hebron-Oncology ( Site 2330), Barcelona, Not set
HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 2337), Sevilla, Not set
Chi Mei Hospital - Liouying Branch ( Site 3908), Tainan City, Tainan
National Taiwan University Cancer Center (NTUCC) ( Site 3907), Taipei City, Taipei
National Taiwan University Hospital - Hsinchu branch ( Site 3901), Hsinchu, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 3904), Kaohsiung, Not set
Chang Gung Memorial Hospital at Kaohsiung ( Site 3902), Kaohsiung, Not set
Taichung Veterans General Hospital-Chest ( Site 3905), Taichung, Not set
National Cheng Kung University Hospital-Clinical Trial Center ( Site 3903), Tainan, Not set
National Taiwan University Hospital-Oncology ( Site 3906), Taipei, Not set
Chulalongkorn University-Medicine ( Site 4003), Bangkok, Krung Thep Maha Nakhon
Faculty of Medicine Siriraj Hospital ( Site 4000), Bangkok, Krung Thep Maha Nakhon
Maharaj Nakorn Chiang Mai Hospital-Chiang Mai Clinical Trial Unit (CM-CTU) ( Site 4001), Chiang Mai, Not set
Medipol Mega Universite Hastanesi-oncology ( Site 2508), Stanbul, Istanbul
Ege Universitesi Hastanesi-Chest Diseases Department ( Site 2503), Bornova, Izmir
Erciyes University ( Site 2511), Talas, Kayseri
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2507), Adana, Not set
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi-oncology ( Site 2506), Ankara, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 2501), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 2505), Ankara, Not set
Ankara Bilkent Şehir Hastanesi ( Site 2500), Ankara, Not set
Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre-Oncolgyy-Hematology ( Site 2510), Denizli, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2502), Istanbul, Not set
Ondokuz Mayıs Universitesi ( Site 2509), Samsun, Not set
Royal Free Hospital ( Site 2601), London, England
Queen Alexandra Hospital-Oncology Department ( Site 2603), Portsmouth, Hampshire
Kent and Canterbury Hospital-Oncology Research ( Site 2606), Canterbury, Kent
Guy's & St Thomas' NHS Foundation Trust-Oncology & Haematology Clinical Trials ( Site 2605), London, London, City Of
James Cook University Hospital ( Site 2604), Central Middlesbrough, Middlesbrough
K Hospital - National Cancer Hospital ( Site 4174), Hanoi, Ha Noi
National Lung Hospital-Oncology Department ( Site 4175), Hanoi, Ha Noi
Tam Anh General Hospital ( Site 4179), Hanoi, Ha Noi
Thong Nhat Hospital ( Site 4170), HCM, Ho Chi Minh
Cho Ray Hospital ( Site 4171), Ho Chi Minh, Not set
Ho Chi Minh City Oncology Hospital - Tan Phu Ward ( Site 4173), Ho Chi Minh, Not set
Conditions: Non-small Cell Lung Cancer (NSCLC)
Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)
Recruiting
The primary objective of this phase III study is to evaluate whether the combination of lurbinectedin plus doxorubicin given as first line treatment for metastatic leiomyosarcoma (LMS) prolongs the progression-free survival (PFS) by Independent Review Committee (IRC) when compared to doxorubicin administered as a single agent.
The primary objective of this phase III study is to evaluate whether the combination of lurbinectedin plus doxorubicin given as first line treatment for metastatic leiomyosarcoma (LMS) prolongs the progression-free survival (PFS) by Independent Review Committee (IRC) when compared to doxorubicin administered as a single agent. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Mayo Clinic Hospital - Phoenix, Phoenix, Arizona +84 locations
Mayo Clinic Hospital - Phoenix, Phoenix, Arizona
Precision NextGen Oncology, Beverly Hills, California
Cedars-Sinai Medical Center, Los Angeles, California
Norris Comprehensive Cancer Center, Los Angeles, California
Sarcoma Oncology Center, Los Angeles, California
Mayo Clinic - Jacksonville, Jacksonville, Florida
Augusta University Georgia Cancer Center, Augusta, Georgia
Massachusetts General Hospital, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
University of Michigan, Ann Arbor, Michigan
Mayo Clinic - Rochester, Rochester, Minnesota
Washington University School of Medicine in St. Louis, Saint Louis, Missouri
Cleveland Clinic Main Campus, Cleveland, Ohio
Oregon Health and Science University, Portland, Oregon
University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania
Vanderbilt - Ingram Cancer Center, Nashville, Tennessee
University of Texas MD Anderson Cancer Center, Houston, Texas
Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location, Seattle, Washington
Universitaetsklinikum Graz - Universitätsklinik für Innere Medizin, Graz, Not set
Medizinische Universität Innsbruck, Innsbruck, Not set
Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz, Not set
Medizinische Universität Wien, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
Cliniques Universitaires Saint-Luc, Brussels, Not set
Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Not set
Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz, Besançon Cedex, Doubs
Institut de Cancérologie de l'Ouest - Angers, Angers cedex 02, Pays De La Loire
Centre Antoine Lacassagne, Nice Cedex 2, Provence Alpes Cote D-Azur
Centre Léon Bérard, Lyon, Rhone-Alpes
Institut Bergonié, Bordeaux, Not set
Centre de Lutte contre le Cancer - Centre Oscar Lambret, Lille, Not set
Centre Hospitalier Universitaire Dupuytren 1, Limoges, Not set
Hôspital de la Timone, Marseille Cedex 5, Not set
Institut Curie, Paris, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
Centre Eugène Marquis, Rennes Cedex, Not set
Institut de Cancérologie de l'Ouest - Saint-Herblain - Site René Gauducheau, Saint-Herblain, Not set
Gustave Roussy, Villejuif, Not set
LMU Klinikum - Campus Großhadern, München, Bayern
Helios Klinikum Bad Saarow, Bad Saarow, Not set
Universitatsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Universitätsklinikum Heidelberg, Heidelberg, Not set
Universitätsmedizin Mannheim, Manheim, Not set
Universitätsklinikum Münster, Münster, Not set
Universitätsklinikum Tübingen, Tübingen, Not set
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas, Rozzano, Milan
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Naples
Centro di Riferimento Oncologico, Aviano, Not set
Istituto Ortopedico Rizzoli, Bologna, Not set
Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi, Bologna, Not set
Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia, Candiolo, Not set
Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano, Not set
Istituto Oncologico Veneto - IRCCS, Padova, Not set
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo, Not set
Università Campus Bio-Medico di Roma, Roma, Not set
Istituto Nazionale Tumori Regina Elena, Roma, Not set
Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino, Not set
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw, Mazowieckie
Szpitale Pomorskie Spółka Z Ograniczoną Odpowiedzialnością, Gdynia, Pomorskie
Unidade Local de Saúde de Coimbra, Coimbra, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Not set
Complejo Hospitalario Universitario A Coruña, A Coruña, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Universitari Vall d'Hebrón, Barcelona, Not set
Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), Barcelona, Not set
Hospital Universitario de Canarias, La Laguna, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Clínico San Carlos, Madrid, Not set
Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
START Madrid - CIOCC - HM Sanchinarro, Madrid, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
Hospital Clínico Universitario de Valencia, Valencia, Not set
Hospital Universitari i Politècnic La Fe, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Universitätsspital Basel, Basel, Not set
Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Not set
University Hospital Birmingham NHS Foundation Trust, Birmingham, Not set
Cambridge University Hospitals NHS Foundation Trust, Cambridge, Not set
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, Not set
University College London Hospitals NHS Foundation Trust, London, Not set
The Royal Marsden NHS Foundation Trust, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Oxford University Hospitals NHS Foundation Trust, Oxford, Not set
Conditions: Leiomyosarcoma
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
Recruiting
The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine.
The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine. Read Less
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
08/13/2025
Locations: Ki Health Partners LLC DBA New England Institute for Clinical Research, Stamford, Connecticut +57 locations
Ki Health Partners LLC DBA New England Institute for Clinical Research, Stamford, Connecticut
NW FL Clinical Research Group, LLC, Gulf Breeze, Florida
A G A Clinical Trials, Hialeah, Florida
Axcess Medical Research, Loxahatchee Groves, Florida
University of South Florida, Tampa, Florida
University of Kentucky, Lexington, Kentucky
University of Maryland School of Medicine, Baltimore, Maryland
Michigan Head Pain and Neurological Institute, Ann Arbor, Michigan
Michigan State University - Department of Neurology, East Lansing, Michigan
Helen Devos Childrens' Hospital, Grand Rapids, Michigan
Dent Neurosciences Research Center Incorporated, Amherst, New York
True North Neurology, Commack, New York
OnSite Clinical Solutions, LLC - Randolph Rd - Charlotte - ClinEdge - PPDS, Charlotte, North Carolina
Childrens Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center - PIN, Cincinnati, Ohio
Road Runner Research Ltd, San Antonio, Texas
Marshall University Medical Center, Huntington, West Virginia
Children's Wisconsin - Milwaukee Campus, Milwaukee, Wisconsin
Hospital Privado de La Comunidad, Mar Del Plata, Buenos Aires
Expertia S.A- Mautalén Salud e Investigación, Ciudad Autónoma de Buenos Aires, Ciudad Autónoma De BuenosAires
Hospital de Niños de La Santisima Trinidad, Córdoba-Barrio Crisol, Córdoba
Instituto Médico Río Cuarto, Río Cuarto, Córdoba
INECO Neurociencias Oroño, Rosario, Santa Fe
Centro de Investigaciones Médicas Tucumán - PPDS, San Miguel de Tucuman, Tucumán
Vancouver Island Health Authority, Victoria, British Columbia
The Kids Clinic, Ajax, Ontario
London Health Sciences Centre -800 Commissioners Rd E, London, Ontario
IRCCS Ospedale Pediatrico Bambino Gesù - INCIPIT - PIN, Roma, Lazio
IRCCS Istituto Giannina Gaslini, Genova, Liguria
Ospedale San Raffaele S.r.l. - INCIPIT - PIN, Milano, Lombardia
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Lombardia
AO Brotzu - Clinica di Neuropsichiatria dell'Infanzia e dell'Adolescenza - INCIPIT - PIN, Cagliari, Sardegna
Azienda Ospedaliero Universitaria A Meyer - INCIPIT - PIN, Firenze, Toscana
Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara, Pisa, Toscana
Fondazione Istituto Neurologico Nazionale Casimiro Mondino IRCCS, Pavia, Not set
Centro de Investigacion Medico Biologica y de Terapia Avanzada S.C., Guadalajara, Jalisco
Clinical Research Institute SC-Mexico, Ampl San Lucas Tepetlacalco, México
ICARO Investigaciones en Medicina, S.A de C.V, Chihuahua, Not set
Instituto de Investigationes Clinicas para la Salud A.C., Durango, Not set
ULS de Almada-Seixal, EPE - Hospital Garcia de Orta, Almada, Setúbal
ULS de Santo António, EPE - Centro Materno Infantil Norte, Porto Covo, Setúbal
Centro Clínico Académico, Braga - Hospital de Braga, Braga, Not set
ULS de Coimbra, EPE - Hospital Pediátrico de Coimbra, Coimbra, Not set
ULS de São João, EPE - Hospital de São João, Porto, Not set
Childrens University Hospital, Belgrade, Not set
University Clinical Center Kragujevac, Kragujevac, Not set
University Clinical Center Nis, Nis, Not set
Children and Youth Health Care Institute of Vojvodina, Novi Sad, Not set
CHUVI - H.U. Alvaro Cunqueiro, Vigo, Pontevedra
Hospital Universitario Vall d'Hebron - PPDS, Barcelona, Not set
Hospital Clinico San Carlos, Madrid, Not set
Hospital Universitario Virgen del Rocio - PPDS, Sevilla, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Eskisehir Osmangazi Universitesi Tip Fakultesi Hastanesi, Eskisehir, Not set
Mersin University Medical Faculty, Mersin, Not set
Great Ormond Street Hospital - PPDS, London, London, City Of
James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk
Queen Elizabeth University Hospital - PPDS, Glasgow, Not set
Conditions: Migraine
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