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All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
Recruiting
The purpose of this study is to evaluate long-term safety and efficacy of povorcitinib in participants with moderate to severe hidradenitis suppurativa who completed the 54 weeks of study treatment within the originating parent Phase 3 studies (INCB 54707-301 \[NCT05620823\] or INCB 54707-302 \[NCT05620836\]).
The purpose of this study is to evaluate long-term safety and efficacy of povorcitinib in participants with moderate to severe hidradenitis suppurativa who completed the 54 weeks of study treatment within the originating parent Phase 3 studies (INCB 54707-301 \[NCT05620823\] or INCB 54707-302 \[NCT05620836\]). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Investigative Site US303, Phoenix, Arizona +171 locations
Investigative Site US303, Phoenix, Arizona
Investigative Site US240, Scottsdale, Arizona
Investigative Site US307, Fort Smith, Arkansas
Investigative Site US214, Rogers, Arkansas
Investigative Site US315, Laguna Niguel, California
Investigative Site US223, Los Angeles, California
Investigative Site US222, Oakland, California
Investigative Site US226, San Diego, California
Investigative Site US233, Washington, District of Columbia
Investigative Site US309, Clearwater, Florida
Investigative Site US317, Hialeah, Florida
Investigative Site US306, Hollywood, Florida
Investigative Site US320, Hollywood, Florida
Investigative Site US316, Maitland, Florida
Investigative Site US227, Margate, Florida
Investigative Site US204, Miami, Florida
Investigative Site US236, Miami, Florida
Investigative Site US321, North Miami Beach, Florida
Investigative Site US200, Ocala, Florida
Investigative Site US228, Tampa, Florida
Investigative Site US201, Tampa, Florida
Investigative Site US311, Marietta, Georgia
Investigative Site US220, West Dundee, Illinois
Investigative Site US206, Indianapolis, Indiana
Investigative Site US337, Indianapolis, Indiana
Investigative Site US341, Bowling Green, Kentucky
Investigative Site US209, Louisville, Kentucky
Investigative Site US305, Baton Rouge, Louisiana
Investigative Site US207, Metairie, Louisiana
Investigative Site US229, New Orleans, Louisiana
Investigative Site US224, Baltimore, Maryland
Investigative Site US325, Marriottsville, Maryland
Investigative Site US225, Boston, Massachusetts
Investigative Site US304, Boston, Massachusetts
Investigative Site US310, Brighton, Massachusetts
Investigative Site US221, Quincy, Massachusetts
Investigative Site US213, Fort Gratiot, Michigan
Investigative Site US217, Waterford, Michigan
Investigative Site US212, Minneapolis, Minnesota
Investigative Site US302, Saint Louis, Missouri
Investigative Site US239, Omaha, Nebraska
Investigative Site US318, Portsmouth, New Hampshire
Investigative Site US230, East Windsor, New Jersey
Investigative Site US324, Kew Gardens, New York
Investigative Site US202, New York, New York
Investigative Site US210, Rochester, New York
Investigative Site US205, Chapel Hill, North Carolina
Investigative Site US215, Bexley, Ohio
Investigative Site US339, Bexley, Ohio
Investigative Site US330, Boardman, Ohio
Investigative Site US314, Cincinnati, Ohio
Investigative Site US312, Cleveland, Ohio
Investigative Site US203, Gahanna, Ohio
Investigative Site US301, Portland, Oregon
Investigative Site US232, Murfreesboro, Tennessee
Investigative Site US235, Arlington, Texas
Investigative Site US218, Bellaire, Texas
Investigative Site US340, Bellaire, Texas
Investigative Site US238, Pflugerville, Texas
Investigative Site US300, Plano, Texas
Investigative Site US234, San Antonio, Texas
Investigative Site US313, Norfolk, Virginia
Investigative Site US308, Spokane, Washington
Investigative Site AU203, Charlestown, New South Wales
Investigative Site AU205, Kogarah, New South Wales
Investigative Site AU200, Liverpool, New South Wales
Investigative Site AU206, Woolloongabba, Queensland
Investigative Site AU207, Woolloongabba, Queensland
Investigative Site AU201, Carlton, Victoria
Investigative Site AU204, Melbourne, Victoria
Investigative Site AT306, Inssbruck, Not set
Investigative Site AT303, Vienna, Not set
Investigative Site AT305, Vienna, Not set
Investigative Site BE300, Bruxelles, Not set
Investigative Site BE306, Gent, Not set
Investigative Site BE301, Ghent, Not set
Investigative Site BE302, Liege, Not set
Investigative Site BG203, Sofia, Not set
Investigative Site BG202, Sofia, Not set
Investigative Site BG200, Sofia, Not set
Investigative Site BG204, Sofia, Not set
Investigative Site BG201, Stara Zagora, Not set
Investigative Site CA202, Calgary, Alberta
Investigative Site CA204, Edmonton, Alberta
Investigative Site CA200, Surrey, British Columbia
Investigative Site CA301, Winnipeg, Manitoba
Investigative Site CA205, Fredericton, New Brunswick
Investigative Site CA304, Barrie, Ontario
Investigative Site CA308, Hamilton, Ontario
Investigative Site CA303, London, Ontario
Investigative Site CA207, Mississauga, Ontario
Investigative Site CA302, Peterborough, Ontario
Investigative Site CA208, Richmond Hill, Ontario
Investigative Site CA307, Montreal, Quebec
Investigative Site CA206, St-jérôme, Quebec
Investigative Site CA203, St. John's, Not set
Investigative Site CZ301, Ostrava - Poruba, Not set
Investigative Site CZ300, Praha 5, Not set
Investigative Site DK200, Aarhus, Not set
Investigative Site DK201, Roskilde, Not set
Investigative Site FR305, Bordeaux, Not set
Investigative Site FR303, Brest Cedex 2, Not set
Investigative Site FR205, Dijon, Not set
Investigative Site FR307, Le Mans Cedex 9, Not set
Investigative Site FR204, Lyon Cedex 03, Not set
Investigative Site FR304, Marseille Cedex 5, Not set
Investigative Site FR302, Nantes, Not set
Investigative Site FR203, Nice Cedex 3, Not set
Investigative Site FR300, Paris, Not set
Investigative Site FR206, Reims, Not set
Investigative Site FR202, Rouen Cedex, Not set
Investigative Site FR301, Saint Priest En Jarez, Not set
Investigative Site FR306, Toulouse Cedex 9, Not set
Investigative Site DE202, Berlin, Not set
Investigative Site DE203, Bochum, Not set
Investigative Site DE305, Darmstadt, Not set
Investigative Site DE201, Dessau-rosslau, Not set
Investigative Site DE302, Dresden, Not set
Investigative Site DE306, Duesseldorf, Not set
Investigative Site DE207, Erlangen, Not set
Investigative Site DE301, Frankfurt, Not set
Investigative Site DE208, Goettingen, Not set
Investigative Site DE303, Hamburg, Not set
Investigative Site DE300, Hannover, Not set
Investigative Site DE205, Heidelberg, Not set
Investigative Site DE200, Kiel, Not set
Investigative Site DE307, Memmingen, Not set
Investigative Site DE206, Merzig, Not set
Investigative Site GR300, Athens, Not set
Investigative Site GR303, Athens, Not set
Investigative Site GR302, Thessaloniki, Not set
Investigative Site IT200, Ancona, Not set
Investigative Site IT207, Catania, Not set
Investigative Site IT202, Milano, Not set
Investigative Site IT206, Pisa, Not set
Investigative Site IT205, Roma, Not set
Investigative Site IT201, Rozzano, Not set
Investigative Site JP301, Ginowan-shi, Not set
Investigative Site JP304, Itabashi-ku, Not set
Investigative Site JP305, Kurume-shi, Not set
Investigative Site JP300, Kyoto-shi, Not set
Investigative Site JP303, Niigata-shi, Not set
Investigative Site JP308, Sapporo-shi, Not set
Investigative Site JP302, Sendai-shi, Not set
Investigative Site JP309, Shinjuku-ku, Not set
Investigative Site NL302, Breda, Not set
Investigative Site NL303, Groningen, Not set
Investigative Site NL301, Rotterdam, Not set
Investigative Site PL203, Lublin, Not set
Investigative Site PL304, Ostrowiec Swietokrzyski, Not set
Investigative Site PL200, Rzeszow, Not set
Investigative Site PL201, Warszawa, Not set
Investigative Site PL202, Warszawa, Not set
Investigative Site PL301, Wroclaw, Not set
Investigative Site PL302, Wroclaw, Not set
Investigative Site ES203, Alicante, Not set
Investigative Site ES302, Badalona, Not set
Investigative Site ES303, Barcelona, Not set
Investigative Site ES301, Granada, Not set
Investigative Site ES202, Las Palmas de Gran Canaria, Not set
Investigative Site ES204, Madrid, Not set
Investigative Site ES201, Madrid, Not set
Investigative Site ES205, Madrid, Not set
Investigative Site ES305, Madrid, Not set
Investigative Site ES200, Manises, Not set
Investigative Site ES300, Pontevedra, Not set
Investigative Site ES304, Santiago de Compostela, Not set
Investigative Site GB202, Birmingham, Not set
Investigative Site GB200, Dudley, Not set
Investigative Site GB201, Leeds, Not set
Investigative Site GB204, London, Not set
Investigative Site GB203, Salford, Not set
Conditions: Hidradenitis Suppurativa (HS)
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
Recruiting
The reason for this study is to assess the safety and efficacy of donanemab in participants with early Alzheimer's disease. The study duration including screening and follow-up is up to 93 weeks.
The reason for this study is to assess the safety and efficacy of donanemab in participants with early Alzheimer's disease. The study duration including screening and follow-up is up to 93 weeks. Read Less
Gender:
ALL
Ages:
Between 60 years and 85 years
Trial Updated:
08/22/2025
Locations: Hospital Italiano de Buenos Aires, ABB, Not set +140 locations
Hospital Italiano de Buenos Aires, ABB, Not set
Clinica Privada Banfield, Banfield, Not set
Fundación para el Estudio y Tratamiento de Enfermedades Mentales (FETEM), Buenos Aires, Not set
Stat Research S.A., Buenos Aires, Not set
CIPREC, Buenos Aires, Not set
Mautalen Salud e Investigación, Buenos Aires, Not set
Instituto Geriatrico Nuestra Señora de Las Nieves, Buenos Aires, Not set
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Not set
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC), Buenos Aires, Not set
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada, Ciudad Autonoma de Buenos Aires, Not set
Centro de Investigaciones Metabólicas (CINME), Ciudad Autónoma de Buenos Aires, Not set
Centro Médico Arsema, Ciudad Autónoma de Buenos Aires, Not set
IDIM - Instituto de Investigaciones Metabólicas, Ciudad de Buenos Aires, Not set
INSA Instituto de Neurociencia San Agustin, La Plata, Not set
Instituto De Investigaciones Clinicas Quilmes, Quilmes, Not set
INECO Neurociencias Oroño, Rosario, Not set
Emeritus Research, Botany, Not set
Box Hill Hospital, Box Hill, Not set
The Prince Charles Hospital, Brisbane, Not set
NeuroCentrix, Carlton, Not set
Central Coast Neurosciences Research, Erina, Not set
Austin Health, Ivanhoe, Not set
Southern Neurology, Kogarah, Not set
HammondCare, Malvern, Not set
The Alfred Hospital, Melbourne, Not set
Australian Alzheimer's Research Foundation Inc., Nedlands, Not set
The Royal Melbourne Hospital, Parkville, Not set
St Vincent's Hospital, Sydney, Not set
KARA Institute for Neurological Diseases, Sydney, Not set
Central Coast Neurosciences Research (Tumbi Umbi), Tumbi Umbi, Not set
Neurodegenerative Disorders Research, West Perth, Not set
The Queen Elizabeth Hospital, Woodville, Not set
Beijing Hospital, Beijing, Not set
Beijing ChaoYang Hospital, Beijing, Not set
Beijing Friendship Hospital Affiliate of Capital University, Beijing, Not set
Xuanwu Hospital Capital Medical University, Beijing, Not set
Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, Not set
Beijing Anding Hospital - Affiliated Capital University of Medical Science, Beijing, Not set
Beijing Peking Union Medical College Hospital, Beijing, Not set
Chinese PLA General Hospital, Beijing, Not set
The First Hospital of Jilin University, Changchun, Not set
Xiangya Hospital Central South University, Changsha, Not set
The Second Xiangya Hospital of Central South University, Changsha, Not set
West China Hospital, Sichuan University, Cheng Du, Not set
Sichuan Provincial People's Hospital, Chengdu, Not set
The First Afffiliated Hospital of Chongqing Medical University, Chongqing, Not set
Fujian Medical University Union Hospital-1 Bingfanglou, Fuzhou Fujian, Not set
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Not set
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Not set
Guangzhou First People's Hospital, Guangzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
Peking University Sixth Hospital, Haidian District, Not set
The First Affiliated Hospital, Zhejiang University, Hangzhou, Not set
Zhejiang Provincial People's Hospital, Hangzhou, Not set
Sir Run Run Shaw Hospital, Hangzhou, Not set
The Second Affiliated hospital of Zhejiang University school of medicine, Hangzhou, Not set
The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Not set
Jinan Central Hospital, Jinan, Not set
The Second Affiliated Hospital of Nanchang University, Nanchang, Not set
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing, Not set
The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Not set
Nanjing Brain Hospital, Nanjing, Not set
Shanghai Mental Health Center, Shanghai, Not set
Shanghai Sixth People's Hospital, Shanghai, Not set
Huashan Hospital Affiliated Fudan University, Shanghai, Not set
Shanghai Tongji Hospital, Shanghai, Not set
Shanghai General Hospital, Shanghai, Not set
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, Not set
Shanghai East Hospital, Shanghai, Not set
The First Hospital of Hebei Medical University, Shijiazhuang, Not set
The Second Affiliated Hospital of Soochow University, Suzhou, Not set
The First Affiliated Hospital of Soochow University, Suzhou, Not set
Tianjin Huanhu Hospital, Tianjin, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Not set
Renmin Hospital of Wuhan University, Wuhan, Not set
Wuxi People's Hospital, Wuxi, Not set
Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army, Xi'an, Not set
Xianyang Hospital of Yan'an University, Xianyang, Not set
The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Not set
Xuzhou Central Hospital, Xuzhou, Not set
Affiliated Hospital of Jiangsu University, Zhenjiang, Not set
Pusan National University Hospital, Busan, Not set
Hanyang University Guri Hospital, Guri-si, Not set
Chonnam National University Hospital, Gwangju-si, Not set
Inha University Hospital, Incheon, Not set
Chungnam national university hospital, Jung-gu, Not set
Gachon University Gil Medical Center, Namdong-gu, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
Korea University Anam Hospital, Seoul, Not set
The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Not set
Hanyang University Seoul Hospital, Seoul, Not set
Konkuk University Medical Center, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Ewha Womans University Seoul Hospital, Seoul, Not set
Ajou University Hospital, Suwon-si, Not set
Podlaskie Centrum Psychogeriatrii, Białystok, Not set
Centrum Medyczne NEUROMED, Bydgoszcz, Not set
Centrum Badan Klinicznych PI-House sp. z o.o., Gdansk, Not set
Klinika Neuro-Care, Katowice, Not set
Diamond Clinic, Krakow, Not set
Nzoz Neuro-Kard Ilkowski i Partnerzy SPL, Poznan, Not set
Centrum Medyczne Euromedis, Szczecin, Not set
Centrum Medyczne NeuroProtect, Warszawa, Not set
Wroclawskie Centrum Alzheimerowskie, Wroclaw, Not set
Barcelonabeta Brain Research Center, Barcelona, Not set
Fundació ACE, Barcelona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Universitari de Santa Maria, Lleida, Not set
Hospital Universitari General de Catalunya, Sant Cugat del Vallès, Not set
Hospital Universitario Doctor Peset, Valencia, Not set
Hospital Universitari i Politecnic La Fe, València, Not set
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region, Douliu City, Not set
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao-Sung Dist, Not set
Cardinal Tien Hospital, New Taipei City, Not set
New Taipei Municipal TuCheng Hospital, New Taipei City, Not set
Taipei Medical University Shuang Ho Hospital, New Taipei, Not set
China Medical University Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
Tri-Service General Hospital, Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch, Taoyuan, Not set
The Rice Centre - Royal United Hospital, Bath, Not set
Re:Cognition Health - Birmingham, Birmingham, Not set
Re:Cognition Health - Bristol, Bristol, Not set
Surrey and Borders Partnership NHS Foundation Trust, Chertsey, Not set
Dementia Research Unit, Crowborough, Not set
Re:Cognition Health - Guildford, Guildford, Not set
St. George's Hospital, London, Not set
University College London Hospital, London, Not set
Re:Cognition Health - London, London, Not set
Charing Cross Hospital, London, Not set
Queen's Medical Centre, Nottingham University Hospitals, Nottinghamshire, Not set
Re:Cognition Health - Plymouth, Plymouth, Not set
Royal Preston Hospital, Preston, Not set
Moorgreen Hospital, Southampton, Not set
Re:Cognition Health - Winchester, Winchester, Not set
Conditions: Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Tauopathies, Neurodegenerative Diseases, Neurocognitive Disorders, Mental Disorders
Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
Recruiting
TAPISTRY is a Phase II, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in rational, specified combinations in participants with unresectable, locally advanced or metastatic solid tumors determined to harbor specific oncogenic genomic alterations or who are tumor mutational burden (TMB)-high as identified by a validated next-generation sequencing (NGS) assay. Participants with solid tumors... Read More
TAPISTRY is a Phase II, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in rational, specified combinations in participants with unresectable, locally advanced or metastatic solid tumors determined to harbor specific oncogenic genomic alterations or who are tumor mutational burden (TMB)-high as identified by a validated next-generation sequencing (NGS) assay. Participants with solid tumors will be treated with a drug or drug regimen tailored to their NGS assay results at screening. Participants will be assigned to the appropriate cohort based on their genetic alteration(s). Treatment will be assigned on the basis of relevant oncogenotype, will have cohort-specific inclusion/exclusion criteria, and, unless otherwise specified, will continue until disease progression, loss of clinical benefit, unacceptable toxicity, participant or physician decision to discontinue, or death, whichever occurs first. Read Less
Gender:
ALL
Ages:
All
Trial Updated:
08/22/2025
Locations: Southern Cancer Center, Daphne, Alabama +162 locations
Southern Cancer Center, Daphne, Alabama
Western Regional Medical Center at Cancer Treatment Centers of America, Goodyear, Arizona
City of Hope National Medical Center, Duarte, California
Kaiser Permanente Los Angeles, Los Angeles, California
USC Norris Cancer Center, Los Angeles, California
Hoag Memorial Hospital, Newport Beach, California
UC Davis Comprehensive Cancer Center, Sacramento, California
University of California at San Francisco, San Francisco, California
Sarcoma Oncology Center, Santa Monica, California
Children's Hospital Colorado, Aurora, Colorado
Christiana Care Health Srvcs, Newark, Delaware
University of Florida, Gainesville, Florida
Miami Cancer Institute of Baptist Health, Inc., Miami, Florida
Ocala Oncology Center, Ocala, Florida
University Cancer & Blood Center, LLC, Athens, Georgia
St. Alphonsus, Boise, Idaho
Midwestern Regional Med Center, Zion, Illinois
Horizon Oncology Research, Inc., Lafayette, Indiana
New England Cancer Specialists, Scarborough, Maine
Maryland Hematology & Oncology. P.A., Silver Spring, Maryland
St. Joseph Mercy Hospital, Ann Arbor, Michigan
Henry Ford Health System, Detroit, Michigan
University of Minnesota, Minneapolis, Minnesota
Metro-Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota
Washington University, Saint Louis, Missouri
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana, Billings, Montana
Nebraska Methodist Hospital, Omaha, Nebraska
Comprehensive Cancer Centers of Nevada - Eastern Avenue, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
University of New Mexico, Albuquerque, New Mexico
Montefiore Einstein Center for Cancer Care, Bronx, New York
Eastchester Center for Cancer Care, Bronx, New York
National Translational Research Group, New York, New York
Icahn School of Medicine at Mount Sinai, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
New York Cancer and Blood Specialists - Setauket Medical Oncology, Port Jefferson Station, New York
Barrett Cancer Center, Cincinnati, Ohio
Oncology Hematology Care Inc, Cincinnati, Ohio
Providence Portland Medical Center, Portland, Oregon
Consultants in Medical Oncology and Hematology, Broomall, Pennsylvania
Alliance Cancer Specialists, Horsham, Pennsylvania
Virginia Cancer Specialists - Leesburg, Leesburg, Pennsylvania
Cancer Treatment Centers of America, Philadelphia, Pennsylvania
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
PRISMA Health - Greenville, Greenville, South Carolina
The West Clinic, Germantown, Tennessee
St. Jude Children'S Research Hospital, Memphis, Tennessee
Texas Oncology - Central South, Austin, Texas
Mary Crowley Medical Research Center, Dallas, Texas
Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas
Cook Childrens Medical Center, Fort Worth, Texas
The University of Texas MD Anderson Cancer Center, Houston, Texas
Texas Oncology- Northeast Texas, Tyler, Texas
Northwest Medical Specialties, PLLC, Tacoma, Washington
Froedtert and The Medical College of Wisconsin, Milwaukee, Wisconsin
Kinghorn Cancer Centre, Darlinghurst, New South Wales
Sydney Children's Hospital, Randwick, New South Wales
Royal Darwin Hospital, Tiwi, Northern Territory
Princess Alexandra Hospital, Woolloongabba, Queensland
Peter MacCallum Cancer Centre, Melbourne, Victoria
Royal Children's Hospital, Parkville, Victoria
Cliniques Universitaires St-Luc, Bruxelles, Not set
GHdC Site Les Viviers, Charleroi, Not set
UZ Antwerpen, Edegem, Not set
UZ Gent, Gent, Not set
UZ Leuven Gasthuisberg, Leuven, Not set
Hospital Moinhos de Vento, Porto Alegre, Rio Grande Do Sul
Hospital Sírio-Libanês, Sao Paulo, São Paulo
Hospital Sírio-Libanês, Sao Paulo, São Paulo
Hospital A. C. Camargo, Sao Paulo, São Paulo
Clínica Onco Star - Rede D'Or, Sao Paulo, São Paulo
BC Cancer ? Vancouver, Vancouver, British Columbia
London Health Sciences Centre · Victoria Hospital, London, Ontario
The Ottawa Hospital - General Campus, Ottawa, Ontario
The Hospital for Sick Children, Toronto, Ontario
Princess Margaret Cancer Center, Toronto, Ontario
McGill University Health Center, Montreal, Quebec
Beijing Cancer Hospital, Beijing, Not set
Beijing Children's Hospital, Capital Medical University, Beijing, Not set
The First Hospital of Jilin University, Changchun City, Not set
Jilin Cancer Hospital, Changchun, Not set
West China Hospital - Sichuan University, Chengdu City, Not set
Shanghai East Hospital, Shanghai City, Not set
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, Not set
Zhongshan Hospital Fudan Unvierstiy, Shanghai, Not set
Tianjin Cancer Hospital, Tianjin, Not set
First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Not set
Aarhus Universitetshospital, Aarhus N, Not set
Rigshospitalet, København Ø, Not set
Institut Bergonie, Bordeaux, Not set
Centre Oscar Lambret, Lille, Not set
Centre Leon Berard, Lyon, Not set
Hopital de la Timone, Marseille, Not set
Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, Not set
Institut de Cancerologie Gustave-Roussy (IGR), Villejuif, Not set
Uniklinik Essen, Essen, Not set
Georg-August-Uniklinik, Göttingen, Not set
Universitätsklinikum Hamburg-Eppendorf Onkologisches Zentrum Medizinische Klinik II, Hamburg, Not set
Medizinische Hochschule Zentrum Innere Medizin Abt.Gastroenterologie, Endokrinologie und Hepatologie, Hannover, Not set
SLK-Kliniken Heilbronn GmbH;Klinik für Innere Medizin III, Heilbronn, Not set
Praxis für Hämatologie, Onkologie und Palliativmedizin, Mönchengladbach, Not set
Klinikum der Universität München, Campus Großhadern, München, Not set
Universtitätsklinikum Ulm, Ulm, Not set
Uniklinikum, Comprehensive Cancer Center Mainfranken, Würzburg, Not set
Hong Kong Children's Hospital, Hong Kong, Not set
Prince of Wales Hospital, Shatin, Not set
Rambam Health Care Campus, Haifa, Not set
Hadassah University Hospital - Ein Kerem, Jerusalem, Not set
Rabin MC, Petach Tikva, Not set
Sheba Medical Center, Ramat Gan, Not set
Sourasky / Ichilov Hospital, Tel Aviv, Not set
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Campania
Ospedale Pediatrico Bambino Gesù - IRCCS, Roma, Lazio
Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio
Asst Degli Spedali Civili Di Brescia, Brescia, Lombardia
Irccs Istituto Nazionale Dei Tumori (Int), Milano, Lombardia
Istituto Nazionale Tumori di Milano, Milano, Lombardia
Dipartimento di Scienze Pediatriche Adolescenza, Torino, Piemonte
Azienda Ospedaliera Meyer, Firenze, Toscana
Azienda Ospedaliera Universitaria Senese, U.O.C. Immunoterapia Oncologica, Siena, Toscana
National Cancer Center Hospital East, Chiba, Not set
Kindai University Hospital, Osaka, Not set
National Cancer Center Hospital, Tokyo, Not set
Seoul National University Bundang Hospital, Gyeonggi-do, Not set
Seoul National University Hospital- Adult Site, Seoul, Not set
Seoul National University Hospital- Pediatric Site, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center- Adult Site, Seoul, Not set
Samsung Medical Center- Pediatric Site, Seoul, Not set
Auckland City Hospital, Cancer and Blood Research, Auckland, Not set
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gda?sk, Not set
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad, Warszawa, Not set
IPO do Porto, Porto, Not set
PanOncology Trials, San Juan, Not set
National University Hospital, Singapore, Not set
National Cancer Centre, Singapore, Not set
Medical Oncology Centre of Rosebank, Johannesburg, Not set
Hospital Sant Joan De Deu, Esplugues De Llobregas, Barcelona
Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set
Hospital Infantil Universitario Nino Jesus, Madrid, Not set
Clinica Universidad de Navarra Madrid, Madrid, Not set
START Madrid-FJD, Hospital Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
START Madrid. Centro Integral Oncologico Clara Campal, Madrid, Not set
Hospital Universitario la Fe, Valencia, Not set
Universitätsspital Basel (USB), Basel, Not set
Ospedale Regionale di Bellinzona Medizin Onkologie, Bellinzona, Not set
Inselspital, Klinik und Poliklinik für Medizinische Onkologie, Bern, Not set
Unversitätsspital Zürich, Zürich, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
Taipei Veterans General Hospital, Taipei City, Not set
Chang Gung Memorial Hospital-Linkou, Taoyuan County, Not set
National Taiwan University Hospital, Zhongzheng Dist., Not set
Beatson West of Scotland Cancer Centre, Glasgow, Not set
University College London Hospital, London, Not set
Guys and St Thomas NHS Foundation Trust, Guys Hospital, London, Not set
Royal Manchester Children?s Hospital, Manchester, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Conditions: Solid Tumors
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
Recruiting
This will be a global Phase IV, open-label, randomised study to evaluate the safety and tolerability of acalabrutinib (monotherapy, 100 mg orally \[po\], twice daily \[bd\]) compared to investigator's choice of treatment, in patients with CLL (TN or R/R) and moderate to severe cardiac impairment. All patients will have cardiac impairment as defined by LVEF of \< 50%.
Randomisation will be stratified by LVEF \> 40% vs ≤ 40% to stratify for moderate and severe cardiac impairment, which for this s... Read More
This will be a global Phase IV, open-label, randomised study to evaluate the safety and tolerability of acalabrutinib (monotherapy, 100 mg orally \[po\], twice daily \[bd\]) compared to investigator's choice of treatment, in patients with CLL (TN or R/R) and moderate to severe cardiac impairment. All patients will have cardiac impairment as defined by LVEF of \< 50%.
Randomisation will be stratified by LVEF \> 40% vs ≤ 40% to stratify for moderate and severe cardiac impairment, which for this study are defined as follows:
Severe cardiac impairment: in those with LVEF ≤ 40% Moderate cardiac impairment: in those with LVEF \> 40% to \< 50%. The study is planned to take place in approximately 20 centres globally. The study will be conducted in centres that have established close collaboration between the Haematology and Cardiology divisions, preferably with a cardio-oncologist on the team.
An IDMC will be responsible for making recommendations for study continuation. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/22/2025
Locations: Research Site, Charlotte, North Carolina +22 locations
Research Site, Charlotte, North Carolina
Research Site, Columbus, Ohio
Research Site, Philadelphia, Pennsylvania
Research Site, Brno, Not set
Research Site, Hradec Králové, Not set
Research Site, Praha 10, Not set
Research Site, Cagliari, Not set
Research Site, Firenze, Not set
Research Site, Milano, Not set
Research Site, Milan, Not set
Research Site, Pavia, Not set
Research Site, Perugia, Not set
Research Site, Krakow, Not set
Research Site, Poznan, Not set
Research Site, Barcelona, Not set
Research Site, Madrid, Not set
Research Site, Sevilla, Not set
Research Site, Bournemouth, Not set
Research Site, Oxford, Not set
Research Site, Plymouth, Not set
Research Site, Romford, Not set
Research Site, Stockton, Not set
Research Site, Sutton Coldfield, Not set
Conditions: Chronic Lymphocytic Leukaemia, Heart Failure
A Study to Test Whether BI 1839100 Improves Cough in People With Idiopathic Pulmonary Fibrosis or Progressive Pulmonary Fibrosis
Recruiting
Adults 40 years of age and older with idiopathic pulmonary fibrosis (IPF) or 18 years and older with progressive pulmonary fibrosis (PPF) can participate in this study. Only people who have a chronic cough can take part. The purpose of this study is to find out how well BI 1839100 helps reduce coughing in people with IPF or PPF.
Participants who have IPF are put into 4 groups by chance. Participants in 3 groups get different doses of BI 1839100. Participants in 1 group get placebo. Placebo look... Read More
Adults 40 years of age and older with idiopathic pulmonary fibrosis (IPF) or 18 years and older with progressive pulmonary fibrosis (PPF) can participate in this study. Only people who have a chronic cough can take part. The purpose of this study is to find out how well BI 1839100 helps reduce coughing in people with IPF or PPF.
Participants who have IPF are put into 4 groups by chance. Participants in 3 groups get different doses of BI 1839100. Participants in 1 group get placebo. Placebo looks like BI 1839100 but does not contain any medicine. Participants take the treatment for 3 months. After 1 month of treatment, participants who take the highest dose will have coughing measured to find out if the medicine works. If it does not work, the study may be stopped. Participants who have IPF are in the study for slightly longer than 4 months. During this time, they visit the study site 7 times. This study will also measure the effects of BI 1839100 on coughing and lung function in a smaller group of people with PPF.
During the study, coughing is measured over 24 hours about once per month using a portable device given to participants to use during the study. Participants fill in questionnaires about their coughing. Doctors also perform breathing tests that measure how well the lungs are working at the site visits. Researchers compare the results between participants who take BI 1839100 and placebo. The doctors also regularly check participants' health and take note of any unwanted effects. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +178 locations
University of Alabama at Birmingham, Birmingham, Alabama
Critical Care, Pulmonary and Sleep Associates, Lakewood, Colorado
Clinical Research Specialists LLC, Kissimmee, Florida
Northwestern University, Chicago, Illinois
The Iowa Clinic, PC, West Des Moines, Iowa
Advanced Pulmonary Research, Warren, Michigan
Memorial Hospital Gulfport, Gulfport, Mississippi
Renown Regional Medical Center, Reno, Nevada
Northern Westchester Hospital, Mount Kisco, New York
Icahn School of Medicine at Mount Sinai, New York, New York
Columbia University Medical Center-New York Presbyterian Hospital, New York, New York
Duke University Medical Center, Durham, North Carolina
Coastal Carolina Health Care, P.A. Pulmonary and Sleep Medicine, New Bern, North Carolina
Southeastern Research Center-Winston Salem-69289, Winston-Salem, North Carolina
University of Oklahoma-Oklahoma City-59108, Oklahoma City, Oklahoma
Clinical Research Associates of Central PA, DuBois, Pennsylvania
Temple University Hospital, Philadelphia, Pennsylvania
Lowcountry Lung and Critical Care, Charleston, South Carolina
Spartanburg Medical Research, Spartanburg, South Carolina
A & A Research Consultants, LLC, Edinburg, Texas
University of Utah Health Sciences Center, Salt Lake City, Utah
Pulmonary Associates of Richmond, Inc., Richmond, Virginia
Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553, C.a.b.a, Not set
Hospital Britanico de Buenos Aires, Caba, Not set
Centro de Investigación Clinica Belgrano, Caba, Not set
CEDIC - Centro de Investigacion Clinica, Caba, Not set
Consultorios Médicos del Buen Ayre, Capital Federal, Not set
Canberra Hospital, Canberra, Australian Capital Territory
Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales
Macquarie University, Macquarie Park, New South Wales
Launceston Respiratory & Sleep Centre, Launceston, Tasmania
Lung Research Victoria, Footscray, Victoria
Austin Hospital, Heidelberg, Victoria
The Alfred Hospital, Melbourne, Victoria
Institute for Respiratory Health, Nedlands, Western Australia
Medical University of Graz State Hospital - University Hospital Graz, Graz, Not set
Krems University Hospital, Krems, Not set
Kepler Univ. Klinikum Linz, Linz, Not set
Hospital Elisabethinen Linz, Linz, Not set
Clinic Floridsdorf, Vienna, Not set
Klinikum Wels - Grieskirchen GmbH, Wels, Not set
UNIV UZ Gent, Gent, Not set
Centre Hospitalier Universitaire de Liège, Liège, Not set
Liège - HOSP CHR de la Citadelle, Liège, Not set
Serviços Medicos Respirar Sul Fluminense, Barra Mansa, Not set
Faculdade de Medicina de Botucatu - UNESP, Botucatu, Not set
CLARE - Clinica de Pneumologia, Goiania, Not set
Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Not set
Netspiro Clinica Medica Ltda - Respsono, Sao Bernardo do Campo, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
Hospital das Clinicas da FMUSP, São Paulo, Not set
Gordon & Leslie Diamond Health Care Centre (UBC), Vancouver, British Columbia
St. Paul's Hospital (Vancouver), Vancouver, British Columbia
St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec
CIC Mauricie Inc., Trois-Rivieres, Quebec
Beijing Chao-Yang Hospital, Beijing, Not set
The Second Xiangya Hospital Of Central South University, Changsha, Not set
West China Hospital of Sichuan University, Chengdu, Not set
People's Hospital of Sichuan Province, Chengdu, Not set
First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Hangzhou First People's Hospital, Hangzhou, Not set
Zhejiang Hospital, Hangzhou, Not set
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Not set
Anhui Provincial Hospital, Hefei, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Shanghai Chest Hospital, Shanghai, Not set
Shanghai Pulmonary Hospital, Shanghai, Not set
China Shenyang Chest Hospital, Shenyang, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
Affiliated Hospital, Xuzhou Medical college, Xuzhou, Not set
Thomayer University Hospital, Prague, Not set
Odense University Hospital, Odense, Not set
HYKS Keuhkosairauksien tutkimusyksikkö, Helsinki, Not set
Oulun yliopistollinen keskussairaala, Oulu, Not set
TYKS, Turku, Not set
HOP d'Angers, Angers, Not set
HOP Avicenne, Bobigny, Not set
HOP CHU Caen, Caen, Not set
HOP Michallon, La Tronche, Not set
INS Coeur Poumon, Lille, Not set
HOP Nord, Marseille, Not set
HOP Nord Laennec, Nantes, Not set
HOP Bichat, Paris, Not set
HOP Haut-Lévêque, Pessac, Not set
HOP Charles Nicolle, Rouen, Not set
HOP Bretonneau, Tours, Not set
Universitätsklinikum Aachen, AöR, Aachen, Not set
CIMS Studienzentrum Bamberg GmbH, Bamberg, Not set
Vivantes Netzwerk für Gesundheit GmbH, Berlin, Not set
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH, Essen, Not set
Universitätsklinikum Freiburg, Freiburg, Not set
Universitätsklinikum Hamburg, Eppendorf, Hamburg, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg, Heidelberg, Not set
Krankenhaus Bethanien gGmbH, Solingen, Not set
Helios Hanseklinikum Stralsund, Stralsund, Not set
Robert Bosch Gesellschaft für medizinische Forschung mbH, Stuttgart, Not set
Klinikum Würzburg Mitte gGmbH, Würzburg, Not set
Univ. Gen. Hosp. of Ioannina, Ioannina, Not set
Univ. Gen. Hosp. of Patras, Patras, Not set
Hospital of Heraklion (PAGNI), Voutes, Not set
Koranyi National Institute For Pulmonolgy, Budapest, Not set
A. O. Universitaria Careggi, Firenze, Not set
Ospedale Colonnello D Avanzo, Foggia, Not set
Ospedale G.B. Morgagni, Forli', Not set
Azienda Ospedaliera San Martino, Genova, Not set
Ospedale Classificato San Giuseppe, Milano, Not set
Azienda Ospedaliera Universitaria di Padova, Padova, Not set
Pol. Universitario Tor Vergata, Roma, Not set
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Not set
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza, Roma, Not set
Tosei General Hospital, Aichi, Seto, Not set
Chiba University Hospital, Chiba, Chiba, Not set
University of Fukui Hospital, Fukui, Yoshida-gun, Not set
National Hospital Organization Kyushu Medical Center, Fukuoka, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Fukuoka, Not set
Sapporo Medical University Hospital, Hokkaido, Sapporo, Not set
National Hospital Organization Himeji Medical Center, Hyogo, Himeji, Not set
Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Yokohama, Not set
Nagasaki University Hospital, Nagasaki, Nagasaki, Not set
National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Sakai, Not set
Hamamatsu University Hospital, Shizuoka, Hamamatsu, Not set
Tokushima University Hospital, Tokushima, Tokushima, Not set
Kyorin University Hospital, Tokyo, Mitaka, Not set
Toho University Omori Medical Center, Tokyo, Ota-ku, Not set
National Center for Global Health and Medicine, Tokyo, Shinjuku-ku, Not set
The Catholic University of Korea, Bucheon St.Mary's Hospital, Bucheon, Not set
Inje University Haeundae Paik Hospital, Busan, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
Inje University Sanggye Paik Hospital, Seoul, Not set
Kyung Hee University Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
Soonchunhyang University Hospital Seoul, Seoul, Not set
Asan Medical Center, Seoul, Not set
Hospital Sultan Idris Shah Serdang, Kajang, Not set
Institut Perubatan Respiratori, Kuala Lumpur, Not set
Sarawak General Hospital, Kuching, Sarawak, Not set
Amphia Ziekenhuis, Breda, Not set
Erasmus Medisch Centrum-ROTTERDAM-50697, Rotterdam, Not set
Christchurch Hospital, Christchurch, Not set
Waikato Hospital, Hamilton, Not set
Greenlane Clinical Centre, One Tree Hill, Auckland, Not set
Haukeland Universitetssykehus, Bergen, Not set
Akershus Universitetssykehus HF, Lørenskog, Not set
Oslo Universitetssykehus HF, Rikshospitalet, Oslo, Not set
University Clinical Hospital in Bialystok I, Bialystok, Not set
Alergopneuma Medical Center, Swidnik, Not set
Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa, Warsaw, Not set
Singapore General Hospital, Singapore, Not set
Tan Tock Seng Hospital, Singapore, Not set
Hospital General Universitario de Alicante, Alicante, Not set
Hospital Vall d'Hebron, Barcelona, Not set
Hospital de Galdakao, Galdakao, Not set
Hospital de Bellvitge, L'Hospitalet de Llobregat, Not set
Hospital Universitario Infanta Leonor, Madrid, Not set
Hospital Virgen de la Victoria, Malaga, Not set
Hospital Central de Asturias, Oviedo, Not set
Hospital Quirónsalud Madrid, Pozuelo de Alarcón, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Clínico de Santiago, Santiago de Compostela, Not set
Hospital Virgen del Rocío, Sevilla, Not set
Skånes universitetssjukhus, Lund, Lund, Not set
CTC Clinical Trial Consultants AB, Uppsala, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Chang Gung Memorial Hospital(Linkou), TaoYuan, Not set
Chulalongkorn Hospital, Bangkok, Not set
Srinagarind Hospital, Khon Kaen, Not set
Ramathibodi Hospital, Ratchatewi, Not set
Songklanagarind Hospital, Songkhla, Not set
Castle Hill Hospital, Cottingham, Not set
Royal Devon and Exeter Hospital, Wonford, Exeter, Not set
Royal Lancaster Infirmary, Lancaster, Not set
Royal Brompton Hospital, London, Not set
Wythenshawe Hospital, Manchester, Not set
Southampton General Hospital, Southampton, Not set
Conditions: Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Recruiting
The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.
The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +346 locations
University of Alabama at Birmingham, Birmingham, Alabama
Clearview Cancer Institute, Huntsville, Alabama
The University of Arizona Cancer Center - North Campus, Tucson, Arizona
Highlands Oncology Group, Springdale, Arkansas
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California
Profound Research LLC, Oceanside, California
University of California, Irvine (UCI) Health - UC Irvine Medical Center, Orange, California
Stanford Cancer Center, Palo Alto, California
Kaiser Permanente San Diego Mission Road, San Diego, California
BASS Cancer Center, Walnut Creek, California
Hartford Hospital (HH), Hartford, Connecticut
Sibley Memorial Hospital, Washington, District of Columbia
Boca Raton Regional Hospital, Boca Raton, Florida
Florida Cancer Specialists - South, Fort Myers, Florida
University of Florida - Jacksonville, Jacksonville, Florida
Miami Cancer Institute at Baptist Health, Inc., Miami, Florida
Florida Cancer Specialists North, Saint Petersburg, Florida
Comprehensive Hematology Oncology, Saint Petersburg, Florida
Moffitt Cancer Center, Tampa, Florida
Florida Cancer Specialists East, West Palm Beach, Florida
University of Illinois at Chicago, Chicago, Illinois
University of Chicago Medical Center, Chicago, Illinois
Captain James A. Lovell Federal Health Care Center, North Chicago, Illinois
Springfield Clinic Main Campus, Springfield, Illinois
Parkview Research Center at Parkview Regional Medical Center, Fort Wayne, Indiana
Franciscan Health, Indianapolis, Indiana
Baptist Health Lexington, Lexington, Kentucky
Baptist Health Hamburg, Lexington, Kentucky
CHI Saint Joseph Cancer Center - East, Lexington, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Ochsner Health Ochsner Cancer Center - Baton Rouge, Baton Rouge, Louisiana
Ochsner Clinic Foundation, New Orleans, Louisiana
New England Cancer Specialists, Westbrook, Maine
University of Maryland, Baltimore, Maryland
Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Reliant Medical Group, Worcester, Massachusetts
Karmanos Cancer Institute, Detroit, Michigan
Missouri Baptist Medical Center, Saint Louis, Missouri
Jefferson Health - Cherry Hill, Cherry Hill, New Jersey
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey
Sidney Kimmel Cancer Center - Washington Township, Sewell, New Jersey
Columbia University Irving Medical Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Northport VA Medical Center, Northport, New York
Cleveland Clinic, Cleveland, Ohio
Providence Portland Medical Center, Portland, Oregon
Providence St. Vincent Medical Center, Portland, Oregon
Kaiser Permanente Interstate Medical Office Central, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office, Philadelphia, Pennsylvania
Jefferson Hospital Northeast, Philadelphia, Pennsylvania
AHN Allegheny General Hospital, Pittsburgh, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Lexington Medical Center, West Columbia, South Carolina
Tennessee Oncology Chattanooga, Chattanooga, Tennessee
University of Tennessee Medical Center, Knoxville, Tennessee
Sarah Cannon Research Institute, Nashville, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Tennessee Oncology, Nashville, Tennessee
The Center for Cancer and Blood Disorders, Fort Worth, Texas
Houston Methodist Hospital, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
USO - Texas Oncology - San Antonio, San Antonio, Texas
USO - Texas Oncology Gulf Coast, Sugar Land, Texas
USO - US Oncology Research Network, The Woodlands, Texas
The University of Vermont Medical Center Inc., Burlington, Vermont
University of Virginia Health System, Charlottesville, Virginia
VCU Health Adult Outpatient Pavillion, Richmond, Virginia
Swedish Cancer Institute - Edmonds, Edmonds, Washington
Swedish Medical Center, Seattle, Washington
Cancer Care Northwest - Vercler, Spokane Valley, Washington
Northwest Cancer Specialists PC, Vancouver, Washington
University Hospital and UW Health Clinics, Madison, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Icon Cancer Centre Wesley, Auchenflower, Not set
Sunshine Coast University Hospital, Birtinya, Not set
Austin Health, Heidelberg, Not set
ICON Cancer Centre - Kurralta Park, Kurralta Park, Not set
Tamworth Hospital, North Tamworth, Not set
Sir Charles Gairdner Hospital, Perth, Not set
Goulburn Valley Health, Shepparton, Not set
Latrobe Regional Health, Traralgon, Not set
Medizinische Universität Graz, Graz, Not set
Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
Klinik Floridsdorf, Wien, Not set
CHIREC - site delta, Auderghem, Not set
Antwerp University Hospital, Edegem, Not set
UZ Leuven, Leuven, Not set
AZ Delta vzw, Roeselare, Not set
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, Not set
CTO - Centro de Tratamento Oncológico, Belem, Not set
Oncocentro de Minas Gerais, Belo Horizonte, Not set
Hospital Tacchini, Bento Gonçalves, Not set
Centro de Pesquisa Sao Lucas, Campinas, Not set
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará, Fortaleza, Not set
Hospital de Cancer de Londrina, Londrina, Not set
Liga Norte Riograndense Contra o Câncer, Natal, Not set
Hospital São Lucas da PUCRS, Porto Alegre, Not set
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro, Not set
Instituto D'Or Pesquisa e Ensino, Rio de Janeiro, Not set
Instituto D'Or de Pesquisa e Ensino (IDOR), Sao Paulo, Not set
Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo, Not set
Hospital Santa Catarina - Paulista, São Paulo, Not set
Centro Paulista de Oncologia Clínica, São Paulo, Not set
K2 Oncology, Providencia, Not set
FALP, Santiago, Not set
Centro de Oncología de Precisión, Santiago, Not set
Bradfordhill, Santiago, Not set
Anyang Cancer Hospital, Anyang, Not set
Cancer Hospital Chinese Academy of Medical Science, Beijing, Not set
China-Japan Friendship Hospital, Beijing, Not set
Peking University People's Hospital, Beijing, Not set
Beijing Cancer hospital, Beijing, Not set
Jilin Cancer Hospital, Changchun, Not set
Xiangya Hospital Central South University, Changsha, Not set
Xiangya Hospital Central South University, Changsha, Not set
Hunan Cancer Hospital, Changsha, Not set
Hunan Cancer Hospital, Changsha, Not set
West China Hospital, Sichuan University, Cheng Du, Not set
The Third People's Hospital of Chengdu (CDTPH), Chengdu, Not set
Sichuan Cancer hospital, Chengdu, Not set
The Second Affiliated Hospital Chongqing Medical University, Chongqing, Not set
The First People's Hospital of Foshan, Foshan, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Zhejiang Provincial People's Hospital, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
The Second Affiliated hospital of Zhejiang University school of medicine, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Jinan Central Hospital, Jinan, Not set
Shandong Cancer Hospital, Jinan, Not set
Taizhou Hospital of Zhejiang Province, Linhai, Not set
Liuzhou People's Hospital, Liuzhou, Not set
The First Affiliated Hospital of Henan University of Science &Technology, Luoyang, Not set
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Not set
The Second People's Hospital of Neijiang, Neijiang, Not set
Shanghai Chest Hospital, Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Cancer Hospital of Shantou University Medical College, Shantou, Not set
ShenZhen People's Hospital, Shenzhen, Not set
Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center, Shenzhen, Not set
The First Affiliated Hospital of Soochow University, Suzhou, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Not set
Hubei Cancer Hospital, Wuhan, Not set
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Not set
Zhongshan Peoples Hospital, Zhongshan, Not set
ZhuZhou Central Hospital, Zhuzhou, Not set
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Not set
Fakultni nemocnice Bulovka, Prague, Not set
Hospices Civils de Lyon - Hopital Louis Pradel, Bron, Not set
Chu Grenoble Alpes, La Tronche, Not set
Centre Leon Berard, Lyon Cedex08, Not set
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Centre Antoine-Lacassagne, Nice, Not set
Groupe hospitalier Paris saint Joseph, Paris, Not set
Hôpital Européen Georges Pompidou, Paris, Not set
Institut Curie, Paris, Not set
CHU Bordeaux Haut-Leveque, Pessac, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
Institut Jean Godinot, Reims, Not set
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes, Not set
Institut de Cancérologie de l'Ouest, Saint Herblain, Not set
CHU de Toulouse - Hopital Larrey, Toulouse, Not set
Hôpital Robert Schuman, Vantoux, Not set
Gustave Roussy, Villejuif, Not set
Vivantes Klinikum im Friedrichshain - Landsberger Allee, Berlin, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
DRK Kliniken Berlin Mitte, Berlin, Not set
Klinikum Chemnitz, Chemnitz, Not set
MV-Zentrum für Onkologie und Hämatologie, Cologne, Not set
Onkologiezentrum Donauwörth, Donauwörth, Not set
Florence-Nightingale-Krankenhaus, Düsseldorf, Not set
HELIOS Klinikum Erfurt, Erfurt, Not set
Asklepios Fachkliniken München-Gauting, Gauting, Not set
Franziskus-Hospital Harderberg, Georgsmarienhütte, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Krankenhaus Martha-Maria Halle-Dölau, Halle, Not set
Asklepios Klinik Harburg, Hamburg, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Evangelisches Krankenhaus Herne - Eickel, Herne, Not set
Klinikum Köln-Merheim, Köln, Not set
St. Elisabeth-Krankenhaus Leipzig, Leipzig, Not set
Klinikum Nürnberg Nord, Nürnberg, Not set
Robert Bosch Krankenhaus GmbH, Stuttgart, Not set
Universitaetsklinikum Tuebingen, Tübingen, Not set
Agios Savvas Regional Cancer Hospital, Athens, Not set
Errikos Dunant Hospital Center, Athens, Not set
Thoracic General Hospital of Athens "I Sotiria", Athens, Not set
University General Hospital of Heraklion, Heraklion, Not set
University General Hospital of Larissa, Larissa, Not set
University Hospital of Patras, Patras, Not set
Agios Loukas Clinic, Thessaloniki, Not set
European Interbalkan Medical Center, Thessaloniki, Not set
Országos Onkológiai Intézet, Budapest, Not set
Budapesti Uzsoki Utcai Kórház, Budapest, Not set
Farkasgyepui Tudogyogyintezet, Farkasgyepu, Not set
Hemato Oncology Clinic, Ahmedabad, Not set
Galaxy Superspeciality Hospital, Aurangabad, Not set
Rajiv Gandhi Government General Hospital, Chennai, Not set
Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Not set
Thangam Cancer Center - Namakkal, Namakkal, Not set
Savera Cancer & Multi Speciality Hospital, Patna, Not set
Deenanath Mangeshkar Hospital & Research Centre, Pune, Not set
Medipoint Hospitals Pvt. Ltd., Pune, Not set
Malabar Cancer Centre - Thalassery, Thalassery, Not set
Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram, Not set
Pacific Medical College & Hospital, Udaipur, Not set
Tata Memorial Centre - Homi Bhabha Cancer Hospital, Varanasi, Not set
Rambam Health Care Campus, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Sheba Medical Center, Ramat Gan, Not set
Instituto Tumori Giovanni Paolo II, Bari, Not set
Policlinico "G. Rodolico", Catania, Not set
Ospedale San Martino, Genova, Not set
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Not set
ASST Grande Ospedale Metropolitano Niguarda, Milan, Not set
Ospedale San Gerardo-ASST Monza, Monza, Not set
Azienda Ospedaliera Dei Colli, Naples, Not set
Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano, Not set
Istituto Nazionale Tumori Regina Elena, Rome, Not set
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona, Not set
Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
Kyushu University Hospital, Fukuoka, Not set
Saitama Medical University International Medical Center, Hidaka, Not set
Himeji Medical Center, Himeji, Not set
Kansai Medical University Hospital, Hirakata, Not set
Kanazawa University Hospital, Kanazawa, Not set
National Cancer Center Hospital East, Kashiwa, Not set
The Cancer Institute Hospital of JFCR, Koto, Not set
University Hospital,Kyoto Prefectural University of Medicine, Kyoto, Not set
Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Not set
Aichi Cancer Center Hospital, Nagoya, Not set
Miyagi Cancer Center, Natori, Not set
Niigata Cancer Center Hospital, Niigata-shi, Not set
NHO Kinki Chuo Chest Medical Center, Sakai, Not set
Hokkaido University Hospital, Sapporo, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Kanagawa Cardiovascular and Respiratory Center, Yokohama, Not set
Kanagawa cancer center, Yokohama, Not set
Tottori University Hospital, Yonago, Not set
The Catholic University of Korea, Incheon St. Mary's Hospital, Bupyeong-gu, Not set
Pusan National University Hospital, Busan, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Keimyung University Dongsan Hospital, Daegu, Not set
Kyungpook National University Chilgok Hospital, Deagu, Not set
Gangnam Severance Hospital, Yonsei University Health System, Gangnam-gu, Not set
National Cancer Center, Goyang-si, Not set
Chonnam National University Hwasun Hospital, Hwasun-gun, Not set
Yeungnam Univeristy Medical Center, Nam-gu, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Konkuk University Medical Center, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Not set
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
The Catholic University Of Korea St. Vincent's Hospital, Suwon-si, Not set
Pusan National University Yangsan Hospital, Yangsan, Not set
Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL), Amsterdam, Not set
Amsterdam UMC, locatie VUmc, Amsterdam, Not set
Amphia Ziekenhuis, locatie Breda Molengracht, Breda, Not set
Ziekenhuis St. Jansdal, Harderwijk, Not set
ETZ Elisabeth, Tilburg, Not set
St. Antonius Ziekenhuis, locatie Utrecht, Utrecht, Not set
Isala, locatie Zwolle, Zwolle, Not set
Sorlandet Sykehus Arendal, Arendal, Not set
Haukeland Universitetssjukehus, Bergen, Not set
Drammen Sykehus, Vestre Viken HF, Drammen, Not set
Sykehuset Innlandet HF Gjøvik, Gjøvik, Not set
Oslo universitetssykehus, Radiumhospitalet, Oslo, Not set
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Kielce, Not set
Wielkopolskie Centrum Pulmonologii i Torakochirurgii, Poznan, Not set
One Day Med, Szczecin, Not set
Centro Hospitalar E Universitário De Coimbra, Coimbra, Not set
Hospital da Luz Lisboa, Lisboa, Not set
Hospital CUF Porto, Porto, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Lotus-Med, Bucharest, Not set
SC Memorial Healthcare International SRL, Bucharest, Not set
Institutul Oncologic, Cluj, Not set
Ovidius Clinical Hospital OCH, Ovidiu, Not set
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banska Bystrica, Not set
Univerzitná nemocnica Bratislava - Nemocnica Ružinov, Bratislava, Not set
Vychodoslovensky Onkologicky ustav a.s., Kosice, Not set
Hospital Infanta Cristina, Badajoz, Not set
Parc de Salut Mar - Hospital del Mar, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet, Not set
Hospital Jerez de la Frontera, Jerez de la Frontera, Not set
Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitari Son Espases, Palma, Not set
Complejo Hospitalario de Navarra, Pamplona, Not set
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Not set
CHUS - Hospital Clinico Universitario, Santiago de Compostela, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Clinico de Valencia, Valencia, Not set
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Not set
Sahlgrenska Universitetssjukhuset Östra, Göteborg, Not set
Kantonsspital Baden, Baden, Not set
HFR Fribourg - Hôpital Cantonal, Fribourg, Not set
Changhua Christian Hospital, Changhua County, Not set
Buddhist Dalin Tzu Chi General Hospital, Chiayi, Not set
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region, Douliu City, Not set
Hualien Tzu Chi Medical Center, Hualien City, Not set
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
E-Da hospital, Kaohsiung, Not set
Far Eastern Memorial Hospital, New Taipei City, Not set
New Taipei Municipal TuCheng Hospital, New Taipei City, Not set
Chung Shan Medical University Hospital, Taichung City, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi Mei Medical Center, Tainan City, Not set
Chi Mei Hospital - Liouying Branch, Tainan City, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Cancer Center (NTUCC), Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch, Taoyuan, Not set
Baskent University Dr. Turgut Noyan Research and Training Center, Adana, Not set
Adana City Hospital, Adana, Not set
Sakarya University School of Medicine, Adapazari, Not set
Antalya Egitim ve Arastırma Hastanesi, Antalya, Not set
Trakya University, Edirne, Not set
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi, Gaziantep, Not set
İ.A.Ü VM Medical Park Florya Hastanesi, Istanbul, Not set
Izmir Atatürk Training and Research Hospital, Izmir, Not set
Marmara Universitesi Pendik Egitim Arastirma Hastanesi, Pendik, Not set
Samsun Medical Park Hastanesi, Samsun, Not set
Heartlands Hospital, Birmingham, Not set
University Hospitals Sussex NHS Foundation Trust, East Sussex, Not set
Huddersfield Royal Infirmary, Huddersfield, Not set
Royal Marsden Hospital (Sutton), London, Not set
Royal Marsden Hospital (Chelsea), London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Torbay Hospital, Torquay, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer
Recruiting
The efficacy and safety of zanidatamab in combination with physician's choice of chemotherapy compared with trastuzumab in combination with physician's choice of chemotherapy will be evaluated for the treatment of participants with metastatic HER2-positive breast cancer who have progressed on, or are intolerant to, previous T-DXd treatment.
The efficacy and safety of zanidatamab in combination with physician's choice of chemotherapy compared with trastuzumab in combination with physician's choice of chemotherapy will be evaluated for the treatment of participants with metastatic HER2-positive breast cancer who have progressed on, or are intolerant to, previous T-DXd treatment. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Mayo Clinic Scottsdale - PPDS, Phoenix, Arizona +158 locations
Mayo Clinic Scottsdale - PPDS, Phoenix, Arizona
Arizona Oncology Tucson - Wilmot, Tucson, Arizona
University of Arizona Cancer Center, Tucson, Arizona
The Oncology Institute Of Hope And Innovation, Cerritos, California
Los Angeles Hematology Oncology Medical Group Glendale, Glendale, California
USC-Norris Comprehensive Cancer Center - Investigational Drug Service IDS, Los Angeles, California
UCSF at Mission Bay MB, San Francisco, California
University of Colorado-Cancer Center-PPDS, Aurora, Colorado
Rocky Mountain Cancer Centers, Denver, Colorado
Medstar Georgetown University Hospital, Washington, District of Columbia
Washington Cancer Center, Washington, District of Columbia
Florida Cancer Specialists Research South, Fort Myers, Florida
Mayo Clinic Jacksonville - PPDS, Jacksonville, Florida
Florida Cancer Specialists Research North, Saint Petersburg, Florida
Florida Cancer Specialists Research East, West Palm Beach, Florida
Dana Farber Cancer Institute, Boston, Massachusetts
Minnesota Oncology Hematology, Coon Rapids, Minnesota
Mayo Clinic - PPDS, Rochester, Minnesota
Saint Luke's Cancer Institute, Kansas City, Missouri
Hackensack Meridian Health, Hackensack, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Memorial Sloan Kettering, Long Island City, New York
Perlmutter Cancer Center 160 E 34th St, New York, New York
The Mount Sinai Hospital, New York, New York
Columbia University Medical Center 161 Fort Washington, New York, New York
Messino Cancer Center, Asheville, North Carolina
Oncology Hematology Care (OHC), Cincinnati, Ohio
University Hospitals Cleveland Medical Center 11100 Euclid Ave, Cleveland, Ohio
Abramson Cancer Center of The University of Pennsylvania, Philadelphia, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Sarah Cannon Research Institute, Nashville, Tennessee
Texas Oncology - Fort Worth, Fort Worth, Texas
U.T. MD Anderson Cancer Center, Investigational Pharmacy Services, Houston, Texas
Millennium Research and Clinical Development, Houston, Texas
Maryland Oncology Hematology Healing Way - USOR, Irving, Texas
Medical Oncology Hematology Consultants, Irving, Texas
Nexus Health, Irving, Texas
Sansum Clinic 540 W - USOR, Irving, Texas
Texas Oncology Gulf Coast, Irving, Texas
Texas Oncology West, Irving, Texas
Virginia Cancer Specialists, Fairfax, Virginia
Virginia Oncology Associates, Sentara Health, Norfolk, Virginia
Blue Ridge Cancer Care, Roanoke, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
Froedtert and The Medical College of Wisconsin, Milwaukee, Wisconsin
Sunshine Coast University Private Hospital, Birtinya, Queensland
Box Hill Hospital, Melbourne, Victoria
Peninsula and South Eastern Haematology and Oncology Group, Mount Waverly, Victoria
HPS Pharmacies - Adelaide, Adelaide, Not set
The Kinghorn Cancer Centre, Mt Kuring-gai, Not set
St John of God Hospital Subiaco, Subiaco, Not set
Ordensklinikum Barmherzige Schwestern, Linz, Not set
Klinikum Wels-Grieskirchen GmbH - Abteilung für Innere Medizin IV, Wels, Not set
Medizinische Universitat Wien, Wien, Not set
Institute Jules Bordet, Anderlecht, Not set
UZ Antwerpen, Edegem, Not set
Grand Hôpital de Charleroi, Gilly, Not set
CHU UCL Namur - Site Sainte-Elisabeth, Namur, Not set
AZ Delta- Campus Rumbeke, Roeselare, Not set
Hospital Nossa Senhora Da Conceição, Porto Alegre, Rio Grande Do Sul
IEPE Unimed Sorocaba, Sorocaba, Sao Paulo
DASA Hospital Brasilia, Brasilia, Not set
Centro Regional Integrado de Oncologia, Ceara, Not set
Catarina Pesquisa Clinica, Itajaí, Not set
Irmandade Da Santa Casa de Misericordia de Porto Alegre, Port Alegre, Not set
Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul PUCRS, Porto Alegre, Not set
Real Hospital Portugues de Beneficiencia Em Pernambuco, Recife, Not set
Nucleo de Oncologia Da Bahia, Salvador, Not set
Hospital Beneficiencia Portuguesa, Sao Paulo, Not set
Onco Star Sp Oncologia LTDA, Sao Paulo, Not set
Ceon Pesquisas Ltda, São Caetano do Sul, Not set
Jewish General Hospital, Montreal, Not set
The Ottawa Hospital Cancer Centre, Ottawa, Not set
CHU de Québec Université Laval Hôpital du Saint Sacrement, Quebec, Not set
Sunnybrook Research Institute, Toronto, Not set
BC Cancer-Vancouver Center, Vancouver, Not set
Institut Bergonie, Bordeaux Cedex, Not set
Centre François Baclesse, Caen, Not set
Centre Georges François Leclerc, Dijon, Not set
Pharmacie Centre de Cancerologie de la Sarthe, Le Mans, Not set
Centre Oscar Lambret, Lille Cedex, Not set
AP HM Hopital de La Timone, Marseille, Not set
Institut Paoli Calmettes, Marseille, Not set
Pharmacie ICM Val d'Aurelle, Montpellier, Not set
ICANS - Institut de cancérologie Strasbourg Europe, Strasbourg, Not set
Oncopôle Claudius Regaud Pharmacie, Toulouse, Not set
Gustave Roussy, Villejuif, Not set
Helios Klinikum Berlin Buch GmbH Klinik für Gynäkologie und Geburtshilfe, Berlin, Not set
Marienhospital Bottrop gGmbH, Dortmund, Not set
Universitätsklinikum Carl Gustav Carus an der TU, Dresden, Not set
Aretaieio Hospital, Athens, Not set
Athens Medical Center, Athens, Not set
University General Hospital of Patras, Patra, Not set
European Interbalkan Medical Center, Thessaloniki, Not set
IRCCS Centro di Riferimento Oncologico di Aviano CRO, Aviano, Not set
Asst Papa Giovanni Xxiii, Bergamo, Not set
Azienda Ospedaliero Universitaria Di Bologna Policlinico S Orsola Malpighi Via Massarenti, Bologna, Not set
Ospedale San Raffaele S.r.l PPDS, Milano, Not set
Istituto Europeo di Oncologia, Milano, Not set
Azienda Ospedaliero Universitaria di Modena, Modena, Not set
Fondazione IRCCS San Gerardo dei Tintori, Monza, Not set
Istituto Oncologico Veneto - I.R.C.C.S., Padova, Not set
Fondazione IRCCS Policlinico San Matteo, Pavia, Not set
IRCCS Istituto Clinico Humanitas, Rozzano, Not set
Chiba Cancer Center, Chiba-shi, Not set
National Cancer Center Hospital, Chuo-ku, Not set
Osaka International Cancer Institute, Chuo-Ku, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Not set
Fukushima Medical University Hospital, Fukushima, Not set
Saitama Medical University International Medical Center, Hidaka-shi, Not set
Tokai University Hospital, Isesaki-shi, Not set
Sagara Hospital, Kagoshima-Shi, Not set
Kyoto University Hospital, Kyoto, Not set
Aichi Cancer Center, Nagoya-shi, Not set
Nagoya City University Hospital, Nagoya-shi, Not set
Okayama University Hospital, Okayama, Not set
National Hospital Organization Osaka National Hospital, Osaka-Shi, Not set
National Hospital Organization Hokkaido Cancer Center, Sapporo-shi, Not set
Juntendo University Hospital, Tokyo, Not set
Showa University Hospital, Tokyo, Not set
Kanagawa Cancer Center, Yokohama-shi, Not set
Soon Chun Hyang University Cheonan Hospital, Cheonan-si, Not set
Gachon University Gil Medical Center, Namdong-gu, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Gangnam Severance Hospital, Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Wojewódzki Szpital Specjalistyczny W Białej Podlaskiej, Biala Podlaska, Not set
Białostockie Centrum Onkologii im. Marii Skłodowskiej-Curie w Białymstoku, Bialystok, Not set
Pratia MCM Kraków, Kraków, Not set
Pratia Poznan, Poznan, Not set
Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy w Warszawie, Warszawa, Not set
Hospital Universitario A Coruña, A Coruña, Not set
Hospital Universitario de Badajoz, Badajoz, Not set
Hospital Universitari Vall d Hebron, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
ICO Badalona-H.U. Germans Trias i Pujol, Barcelona, Not set
Hospital General Universitario de Elche, Elche, Not set
Hospital Universitario Clinico San Cecilio, Granada, Not set
Hospital Beata Maria Ana, Madrid, Not set
MD Anderson Cancer Center, Madrid, Not set
Hospital Clinico San Carlos, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario de Canarias, San Cristóbal de La Laguna, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Hospital Clínico Universitario de Valencia, Valencia, Not set
CHUVI - H.U. Alvaro Cunqueiro, Vigo, Not set
Royal United Hospital, Bath, Not set
Beatson West Of Scotland Cancer Centre, Glasgow, Not set
Leicester Royal Infirmary, Leicester, Not set
Guy's Hospital, London, Not set
Charring Cross Hospital, London, Not set
The Christie - PPDS, Manchester, Not set
Churchill Hospital, Oxford, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Metastatic HER2-positive Breast Cancer
FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3
Recruiting
The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435 by itself or when it is combined with other standard medicines that treat cancer. LOXO-435 may be used to treat cancer of the cells that line the urinary system and other solid tumor cancers that have a change in a particular gene (known as the FGFR3 gene). Participation could last up to 30 months (2.5 years) and possibly longer if the disease does not get worse.
The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435 by itself or when it is combined with other standard medicines that treat cancer. LOXO-435 may be used to treat cancer of the cells that line the urinary system and other solid tumor cancers that have a change in a particular gene (known as the FGFR3 gene). Participation could last up to 30 months (2.5 years) and possibly longer if the disease does not get worse. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: University of Arizona - Cancer Center, Tucson, Arizona +83 locations
University of Arizona - Cancer Center, Tucson, Arizona
City of Hope, Duarte, California
University of California, Los Angeles (UCLA) - Division of Hematology-Oncology, Los Angeles, California
University of California - Irvine, Orange, California
University of California (UC) Davis Comprehensive Cancer Center, Sacramento, California
Stanford Cancer Center, Stanford, California
Advent Health, Orlando, Florida
Emory University Hospital, Atlanta, Georgia
The University of Chicago Medical Center (UCMC), Chicago, Illinois
Indiana University (IU) Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Ochsner Clinic Foundation, New Orleans, Louisiana
Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
Washington University in St. Louis, Saint Louis, Missouri
Montefiore Medical Center, Bronx, New York
New York University (NYU), New York, New York
Weill Cornell Medicine, New York, New York
Icahn School of Medicine at Mount Sinai, New York, New York
Columbia University, New York, New York
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester - Wilmot Cancer Institute, Rochester, New York
University of North Carolina (UNC) - Chapel Hill, Chapel Hill, North Carolina
University of Cincinnati Medical Center (UCMC), Cincinnati, Ohio
The Ohio State University (OSU), Columbus, Ohio
University of Oklahoma - Health Sciences Center, Oklahoma City, Oklahoma
Penn Medicine Lancaster General Hospital - Ann B. Barshinger Cancer Institute, Lancaster, Pennsylvania
University of Pennsylvania, Philadelphia, Pennsylvania
Thomas Jefferson University, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Carolina Urologic Research Center, Myrtle Beach, South Carolina
Sarah Cannon and HCA Research Institute, Nashville, Tennessee
Tennessee Oncology, Nashville, Tennessee
Vanderbilt University Medical Center, Nashville, Tennessee
University of Texas Southwestern, Dallas, Texas
Texas Oncology, P.A, Dallas, Texas
MD Anderson Cancer Center, Houston, Texas
University of Utah, Salt Lake City, Utah
University of Vermont Medical Center, Burlington, Vermont
Inova Schar Cancer Institute, Falls Church, Virginia
St Vincent's Hospital, Darlinghurst, Not set
Calvary Mater Newcastle, Hunter Region, NSW, Not set
GenesisCare North Shore, St. Leonards, Not set
Macquarie University, Sydney, Not set
Princess Margaret Hospital, Toronto, Not set
British Columbia Cancer Agency, Vancouver, Not set
Beijing Cancer hospital, Beijing, Not set
Beijing Hospital, Beijing, Not set
Sun Yat-Sen University- Cancer Center, Guangdong, Not set
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Not set
Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
First Affiliated Hospital of Medical College of Xian jiaotong University, Xi'an, Not set
Zhejiang Provincial People's Hospital, Zhejiang, Not set
Institut Bergonie, Bordeaux Cedex, Not set
Centre Leon Berard, Lyon, Not set
Institut Gustave Roussy, Villejuif cedex, Not set
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck, Luebeck, Not set
Klinikum der Technischen Universitaet Muenchen (TUM Klinikum), Munchen, Not set
Universitaetsklinikum Tuebingen, Tuebingen, Not set
Rabin Medical Center, Beilinson Hospital, Petach Tikva, Not set
Sheba Medical Center, Tel Hashomer, Not set
IRCCS Ospedale San Raffaele, Milano, Not set
UOC Fase I - Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore, Roma, Not set
National Cancer Center Hospital East, Chiba, Not set
Aichi Cancer Center Hospital, Nagoya, Not set
National Cancer Center Hospital, Tokyo, Not set
Cancer Institute Hospital of JFCR, Tokyo, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Erasmus MC, GE Rotterdam, Not set
Haukeland University Hospital, Bergen, Not set
Oslo University Hospital, Oslo, Not set
Institut Catala d'Oncologia - L'Hospitalet, Barcelona, Not set
Fundacion MD Anderson International Espana, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
South Texas Accelerated Research Therapeutics (START) Madrid - CIOCC, Madrid, Not set
Hospital Universitario Marques De Valdecilla, Santander, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, Not set
Conditions: Urinary Bladder Neoplasms, Neoplasm Metastasis, Ureteral Neoplasms
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Recruiting
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before the study. The purpose of this study is to find out whether a medicine called vicadrostat, in combination with another medicine called empagliflozin, helps people with chronic heart failure.
In this study, participants are put into 2 groups randomly. Participants... Read More
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before the study. The purpose of this study is to find out whether a medicine called vicadrostat, in combination with another medicine called empagliflozin, helps people with chronic heart failure.
In this study, participants are put into 2 groups randomly. Participants have an equal chance of being in either group. One group takes vicadrostat and empagliflozin tablets, and the other group takes placebo and empagliflozin tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine. Participants take the study medicines as tablets once a day for between 1 and about 3.5 years. During this time, they can continue their regular treatment for heart failure.
Participants can stay in the study as long as they benefit from treatment and can tolerate it, for a maximum of about 3.5 years. During this time, they visit the study site regularly. The exact number of visits is different for each participant, depending on how long they stay in the study. The study staff may also contact the participants by phone. Participants also regularly answer questions about their well-being. The doctors document when participants experience worsening of their heart failure symptoms, must go to hospital due to heart failure, or die during the study. The time until these events are observed is compared between the treatment groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Alliance for Multispecialty Research, LLC, Mobile, Alabama +597 locations
Alliance for Multispecialty Research, LLC, Mobile, Alabama
Drug Research and Analysis Corporation, Montgomery, Alabama
Valley Clinical Trials, Inc., Covina, California
North Coast Cardiology, Encinitas, California
Orange County Research Center, Lake Forest, California
Merced Vein and Vascular Center, Merced, California
Radin Cardiovascular Medical Group, Newport Beach, California
Amicis Research Center, Northridge, California
Paradigm Clinical Research - San Diego, San Diego, California
Care Access Research, Thousand Oaks, California
Bridgeport Hospital, Bridgeport, Connecticut
Bay Area Cardiology, Brandon, Florida
Cardiology Associates Research Co., Daytona Beach, Florida
Malcom Randall VA Medical Center, Gainesville, Florida
Velocity Clinical Research-Hallandale Beach-67888, Hallandale Beach, Florida
University of Florida, Jacksonville, Florida
East Coast Institute For Research, LLC, Jacksonville, Florida
First Coast Cardiovascular Institute, Jacksonville, Florida
Jacksonville Center for Clinical Research, Jacksonville, Florida
University of Miami - Miller School of Medicine, Miami, Florida
Innovation Medical Research Center, Palmetto Bay, Florida
Suncoast Research Associates, LLC, Pembroke Pines, Florida
Peace River Cardiovascular Center, Port Charlotte, Florida
St. Johns Center for Clinical Research, Saint Augustine, Florida
Cardiology Partners Clinical Research Institute, Wellington, Florida
Cozy Research LLC, Wesley Chapel, Florida
Clinical Site Partners, LLC, Winter Park, Florida
Columbus Regional Research Institute, Columbus, Georgia
NSC Research Inc, Johns Creek, Georgia
Northwest Heart Clinical Research, LLC, Arlington Heights, Illinois
Illinois Masonic Hospital, Chicago, Illinois
Chicago Medical Research, Hazel Crest, Illinois
Clinical Investigation Specialists, Inc., Libertyville, Illinois
AMR Park Ridge, Park Ridge, Illinois
Springfield Clinic, Springfield, Illinois
Midwest Cardiovascular Research and Education Foundation, Elkhart, Indiana
St. Francis Medical Group-Indiana Heart Physicians, Inc, Indianapolis, Indiana
Indiana Medical Research Institute, Merrillville, Indiana
Cardiovascular Research of Northwest Indiana, LLC, Munster, Indiana
Reid Hospital, Richmond, Indiana
The Iowa Clinic, PC, West Des Moines, Iowa
University of Kansas Medical Center, Kansas City, Kansas
Robert J Dole Veterans Affairs Medical Center, Wichita, Kansas
Kansas Heart Hospital, Wichita, Kansas
West Houston Area Clinical Trial Consultants, LLC, Wichita, Kansas
West Houston Area Clinical Trial Consultants, LLC, Wichita, Kansas
Norton Healtcare - Norton Heart and Vascular Institute, Louisville, Kentucky
Heart Clinic of Hammond, Hammond, Louisiana
Grace Research, LLC-Shreveport-64616, Shreveport, Louisiana
Ascension Saint Agnes Heart Care, Baltimore, Maryland
Metropolitan Cardiovascular Consultants, Beltsville, Maryland
Capitol Cardiology Associates, Lanham, Maryland
McLaren Bay Region Medical Center, Bay City, Michigan
Cardiology and Vascular Associates - CAVA, Bloomfield Hills, Michigan
Michigan Healthcare Professionals Pulse Cardiology, Farmington Hills, Michigan
St. John Providence Hospital, Novi, Michigan
Michigan Heart, PC, Ypsilanti, Michigan
Mayo Clinic, Rochester, Rochester, Minnesota
Regions Hospital, Saint Paul, Minnesota
Jackson Heart Clinic, P.A., Jackson, Mississippi
North Kansas City Hospital, Kansas City, Missouri
Kansas City VA Medical Center, Kansas City, Missouri
St. Louis Heart and Vascular, P.C., Saint Louis, Missouri
Be Well Clinical Studies, Omaha, Nebraska
Advanced Heart Care, LLC, Bridgewater, New Jersey
Garden State Heart Care, PC, Manalapan, New Jersey
Mount Sinai Hospital-New York-52529, New York, New York
Icahn School of Medicine at Mount Sinai, New York, New York
IMA Clinical Research Lenoir, Lenoir, North Carolina
Pinehurst Medical Clinic, Inc. - East, Pinehurst, North Carolina
WakeMed, Raleigh, North Carolina
Piedmont Healthcare, Statesville, North Carolina
Wilmington Health, Wilmington, North Carolina
VA Northeast Ohio Healthcare System, Cleveland, Ohio
K and R Research LLC, Marion, Ohio
Cardiology Consultants of Philadelphia, Philadelphia, Pennsylvania
Bon Secours Medical Group Greenville Specialty Care, LLC, Greenville, South Carolina
Monument Health, Rapid City, South Dakota
Pharmatex Research, Amarillo, Texas
Amarillo Heart Clinical Research Institute, Incorporated, Amarillo, Texas
NextStage Clinical Research, Beaumont, Texas
Texas Health Research and Education Institute, Dallas, Texas
Southwest Family Medicine Associates, Dallas, Texas
Helios CR Inc - Fort Worth, Fort Worth, Texas
Heart & Peripheral Vascular Consultants, LLC, Harlingen, Texas
The Methodist Hospital Research Institute, Houston, Texas
DM Clinical Research Dallas, Irving, Texas
DCOL Center for Clinical Research, Longview, Texas
North Texas Research Associates, McKinney, Texas
Texas Institute Of Cardiology, McKinney, Texas
Stryde Research, Plano, Texas
Accurate Clinical Research, Inc., Richmond, Texas
Revival Research Institute, LLC., Sherman, Texas
Baylor Scott and White Health, Temple, Texas
Northwest Heart Center, Tomball, Texas
NextStage Clinical Research, Waco, Texas
Virginia Heart - Falls Church, Falls Church, Virginia
Carient Heart and Vascular, Manassas, Virginia
Sentara Norfolk General Hospital, Norfolk, Virginia
Inst de Inv Clinicas-Bahia Blanca, Bahia Blanca, Not set
Hospital Regional de Bahia Blanca, Bahia Blanca, Not set
Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553, C.a.b.a, Not set
Hospital Italiano de Buenos Aires, Ciudad Autonoma Buenos Aires, Not set
Fundacion Favaloro, Ciudad Autonoma Buenos Aires, Not set
Mautalen- Salud e Investigacion, Ciudad Autonoma Buenos Aires, Not set
Centro Medico Dra Laura Maffei, Ciudad Autonoma Buenos Aires, Not set
Glenny Corp. S.A. Bioclinica Argentina, Ciudad Autonoma Buenos Aires, Not set
CIPREC, Ciudad Autonoma de Buenos Aires, Not set
Sanatorio Allende, Cordoba, Not set
Clinica Privada Colombo- Fundacion Clinica Colombo, Cordoba, Not set
Instituto Médico DAMIC S.R.L., Cordoba, Not set
Centro Medico Luquez, Cordoba, Not set
Clinica Coronel Suárez, Coronel Suarez, Not set
Well Medica, Córdoba, Not set
Hospital Italiano de La Plata, La Plata, Not set
Centro de Investigaciones Medicas Mar del Plata, Mar del Plata, Not set
Hospital Universitario Austral, Pilar, Not set
Instituto Medico CER, Quilmes, Not set
Instituto de Investigaciones Clínicas de Quilmes, Quilmes, Not set
DIM Clinica Privada, Ramos Mejía, Not set
INECO Neurociencias Oroño, Rosario, Not set
Instituto de Investigaciones Clinicas de Rosario, Rosario, Not set
Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica, Rosario, Not set
Sanatorio Parque, Rosario, Not set
Instituto CAICI, Rosario, Not set
Investigaciones Clinicas Salta (ICSAL), Salta, Not set
Centro Cardiovascular Salta, Salta, Not set
Corporacion Medica de Gral. San Martin S.A., San Martin, Not set
Investigaciones en Patologias Respiratorias, San Miguel de Tucuman, Not set
Investigaciones Clinicas Tucuman, San Miguel de Tucuman, Not set
Centro Integral de Arritmias Tucuman, San Miguel de Tucuman, Not set
Centro Modelo de Cardiologia, San Miguel de Tucuman, Not set
Clinica Mayo, San Miguel de Tucuman, Not set
Instituto de Investigaciones Clinicas San Nicolas, San Nicolas, Not set
Centro de Investigaciones Clinicas Baigorria, Santa Fe, Not set
Hospital "Dr. José Maria Cullen", Santa Fe, Not set
Centro de Investigaciones Clínicas del Litoral, Santa Fe, Not set
CEMEDIC - Centro de Especialidades Medicas, Villa Luro, Not set
AZ Sint-Blasius, Dendermonde, Not set
Ziekenhuis Oost-Limburg - Campus Sint-Jan, Genk, Not set
AZ Sint-Lucas, Gent, Not set
Grand Hôpital de Charleroi, Gilly, Not set
Kortrijk - HOSP AZ Groeninge Kennedylaan, Kortrijk, Not set
La Louvière - UNIV CHU Tivoli, La Louvière, Not set
Liège - HOSP CHR de la Citadelle, Liège, Not set
Hospital Sirio Libanes, Bela Vista, Not set
Hospital Felicio Rocho, Belo Horizonte, Not set
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda, Belo Horizonte, Not set
L2IP -Instituto de Pesquisas Clínicas Ltda., Brasília, Not set
Hospital DF Star, Brasília, Not set
CECAP - Centro de Cardiologia Clínica, Brasília, Not set
Hospital Angelina Caron, Campina Grande do Sul, Not set
IPECC - Instituto de Pesquisa Clínica de Campinas, Campinas, Not set
Hospital PUC-Campinas, Campinas, Not set
I9 Pesquisas Clinicas - Loema Instituto de Pesquisa Clínica e Consultores SS Ltda, Campinas, Not set
Hospital do Rocio, Campo Largo, Not set
Fundacao Universidade de Caxias do Sul, Caxias do Sul, Not set
PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR, Curitiba, Not set
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás, Goiania, Not set
Via Medica, Goiânia, Not set
ICM - Instituto do Coracao de Marilia, Marília, Not set
Hospital Vera Cruz, Minas Gerais, Not set
Instituto Atena de Pesquisa Clinica, Natal, Not set
Instituto Mederi de Pesquisa e Saude, Passo Fundo, Not set
Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set
Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Not set
Universidade Federal do Rio Grande do Sul, Porto Alegre, Not set
Hospital Mae de Deus, Porto Alegre, Not set
Hospital Esperança Recife, Recife, Not set
Clinicor Clínica Cardiológica LTDA/ Cardio Prime - CAPED, Ribeirão Preto, Not set
Instituto Brasil de Pesquisa Clinica (IBPClin), Rio de Janeiro, Not set
Ruschel Medicina e Pesquisa Clínica, Rio de Janeiro, Not set
Instituto D'Or Pesquisa e Ensino - Rio de Janeiro, Rio de Janeiro, Not set
Hospital Cardio Pulmonar, Salvador, Not set
Pesquisare, Santo Andre, Not set
Praxis Pesquisa Medica, Santo Andre, Not set
Cpquali Pesquisa Clinica Ltda, Sao Paulo, Not set
Centro de Pesquisa Clinica - CPCLIN, Sao Paulo, Not set
CEPIC - Centro Paulista de Investigacao Clinica, Sao Paulo, Not set
Instituto Domingo Braile, São José do Rio Preto, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
CIPES - Centro Internacional de Pesquisa Clínica, São José dos Campos, Not set
Eurolatino Pesquisas Médicas Ltda., Uberlandia, Not set
CEDOES - Diagnóstico e Pesquisa,Vitória, Vitória, Not set
Medical Center Doktor Staykov Ltd., Burgas, Not set
Diamedical Medical Center 2013, Dimitrovgrad, Not set
Medical Center New Polyclinic Gabrovo Ltd., Gabrovo, Not set
Medical Center Rodopimed EOOD, Kardzhali, Not set
MEDICAL CENTER HERA - Kyustendil EOOD, Kyustendil, Not set
Ambulatory Individual Practice for Cardiology Specialized Medical Care, Pernik, Not set
Medical Center Medconsult Pleven LTD, Pleven, Not set
MHAT Heart and brain, Pleven, Not set
UMHAT Sv.Georgi, Plovdiv, Not set
Medical Center For Specialized Medical Help In Cardiovascular Diseases OOD, Sofia, Not set
National Multiprofile Transport Hospital, Sofia, Sofia, Not set
Diagnostic Consultative Center Alexandrovska, Sofia, Not set
University Multidisciplinary Hospital for Active Treatment Sveta Ekaterina EAD, Sofia, Not set
University Multiprofile Hospital for Active Treatement "Alexandrovska" EAD, Sofia, Not set
Medical Center Hera EOOD, Sofia, Not set
MHAT "Tsaritsa Yoanna-ISUL" Clinic of Cardiology, Sofia, Sofia, Not set
ASOMHIDC - Individual practice "Cardio Tonus" EOOD, Sofia, Not set
Diagnostic Consultation Center XX-Sofia EOOD, Sofia, Not set
MHAT "St. Sofia", Sofia, Not set
Kalimat Medical Center Ltd., Sofia, Not set
Medical Center Intermedica Ltd., Sofia, Not set
Medical Center Medicabilis Ltd., Sofia, Not set
Medical Centre Nevromedics EOOD, Veliko Tarnovo, Not set
Multiprofile Hospital For Active Treatment St. Panteleimon Yambol AD, Yambol, Not set
Cambridge Cardiac Care Centre, Cambridge, Ontario
Saul Vizel Medicine Professional Corporation, Cambridge, Ontario
Premier Clinical Trial Network, Hamilton, Ontario
Elevate Clinical Research - KMH Hamilton, Kitchener, Ontario
KMH Cardiology Centres (Mississauga), Mississauga, Ontario
Oakville Trafalgar Memorial Hospital, Oakville, Ontario
James Cha, MD, Oshawa, Ontario
Kawartha Cardiology Clinical Trials, Peterborough, Ontario
CardioQuest Research Centre, Sarnia, Ontario
Niagara Health System - St. Catharines Site, St. Catharines, Ontario
Health Sciences North, Sudbury, Ontario
ViaCar Recherches Cliniques Inc. (Brossard), Brossard, Quebec
Diex Recherche (Trois-Rivieres), Trois-Rivieres, Quebec
CardioVasc HR Inc., St. Jean sur Richelieu, Not set
Enroll Spa, Santiago, Not set
CeCim - Centro de Estudios Clinicos e Investigacion Medica, Santiago, Not set
Hospital Las Higueras, Talcahuano, Not set
Centro de Investigación del Maule, Talca, Not set
CECMI Ltda, Temuco, Not set
CINVEC - Centro de Investigacion Clinica V Reg.,Vina del Mar, Viña del Mar, Not set
Beijing AnZhen Hospital, Beijing, Not set
Cardiovascular Institute and Fu Wai Hospital, Beijing, Not set
Jilin Province People's Hospital, Changchun, Not set
The First Hospital of Jilin University, Changchun, Not set
China-Japan Union Hospital of Jilin University, Changchun, Not set
Changde Second People's Hospital, Changde City, Not set
Hunan Province People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Not set
The Second Xiangya Hospital Of Central South University, Changsha, Not set
The Third Hospital of Changsha, Changsha, Not set
People's Hospital of Sichuan Province, Chengdu, Not set
Chenzhou No.1 people's Hospital, Chenzhou, Not set
Second Affiliated Hospital Chongqing Medical University, Chongqing, Not set
Chongqing Three Gorges Central Hospital, Chongqing, Not set
Affiliated Zhongshan Hospital of Dalian University, Dalian, Not set
Daqingshi People's Hospital, Daqing, Not set
People's Hospital of Deyang City, Deyang, Not set
The First People's Hospital of Foshan, Foshan, Not set
The First Affiliated Hospital of Fujian Medical University, Fuzhou, Not set
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Not set
Guangdong Provincial People's Hospital, Guangzhou, Not set
Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, Not set
Guizhou People's Hospital, Guiyang, Not set
Hainan General Hospital, Haikou, Not set
The First Affiliated Hospital of Harbin Medical University, Harbin, Not set
Jiangmen Central Hospital, Jiangmen, Not set
Center Hospital of Jinan, Jinan, Not set
Lanzhou University Second Hospital, Lanzhou, Not set
Linfen Central Hospital, Linfen, Not set
Luoyang Third People's Hospital, Luoyang, Not set
The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Not set
Jiangxi Province Integrated Tractional Chinese Medicine& Western Medicine Hospital, Nanchang, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Zhongda Hospital Southeast University, Nanjing, Not set
Nanjing Jiangning Hospital, Nanjing, Not set
The First Affiliated Hospital of Guangxi Medical University, Nanning, Not set
Nanyang First People's Hospital, Nanyang, Not set
Nanyang Second General Hospital, Nanyang, Not set
Ningbo Second Hospital, Ningbo, Not set
The First Affiliated Hospital of Ningbo University, Ningbo, Not set
Panjin Liao Oil Gem Flower Hospital, Panjin, Not set
Pingxiang People's Hospital, Pingxiang, Not set
Zhongshan Hospital Affiliated to Fudan University, Shanghai, Not set
Tongren hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Not set
Shanghai General Hospital, Shanghai, Not set
Shengjing Hospital of China Medical University, Shenyang, Not set
People's Hospital of Liaoning Province, Shenyang, Not set
Shenzhen People's Hospital, Shenzhen, Not set
The Second Hospital of Hebei Medical University, Shijiazhuang, Not set
Taian City Central Hospital, Tai'an, Not set
Shanxi Cardiovascular Hospital, Taiyuan, Not set
Shanxi Bethune Hospital, Taiyuan, Not set
Tianjin Union Medical Center Nankai University Affiliated Hospital, Tianjin, Not set
The 2nd Hospital of Tianjin Medical University, Tianjin, Not set
Hubei Province Zhongshan Hospital, Wuhan, Not set
Renmin Hospital of Wuhan University, Wuhan, Not set
Shaanxi Provincial People's Hospital, XI An, Not set
Xinxiang Central Hospital, Xinxiang, Not set
The People's Hospital Of Xuancheng City, Xuancheng, Not set
The first People's Hosptal of Yinchuan, Yinchuan, Not set
Yueyang Central Hospital, Yueyang, Not set
Yuncheng Central Hospital, Yuncheng, Not set
The First Affiliated Hospital of Hebei North University, Zhangjiakoou, Not set
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Not set
Affiliated Hospital of Jiangsu University, Zhenjiang, Not set
Cardiomet CEQUIN S.A.S, Armenia, Not set
Centro de Investigacion Medico Asistencial S.A.S, Barranquilla, Not set
Corazon IPS S.A.S., Barranquilla, Not set
Fundacion Santa Fe de Bogota, Bogota, Not set
Administradora Country S.A.S., Bogota, Not set
Fundacion Hospital Infantil Universitario de San José, Bogota, Not set
IPS Centro Medico Julián Coronel S.A., Cali, Not set
Centro de Diagnostico Cardiologico para la Investigacion Bio, Cartagena, Not set
IPS médicos internistas de Caldas S.A.S., Manizales, Not set
T Y C Inversiones S.A.S Grupsalud, Santa Marta, Not set
MUDr. Hana Burianova, Bilovec, Not set
Medicus Services Ltd., Brandys nad Labem, Not set
Interni Ordinace s.r.o., Brandýs nad Labem, Not set
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno, Brno, Not set
Fakultni nemocnice u sv. Anny v Brne, Brno, Not set
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance, Chrudim, Not set
EDUMED s.r.o., Jaromer, Not set
MUDr Petra Maskova PhD, Litovel, Not set
KardioBusak s.r.o., Louny, Not set
InterKardioML s.r.o., Marianske Lazne, Not set
MUDr. Zdenek Vomacka kardiologie a interna s.r.o., Olomouc, Not set
MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna, Praha 10, Not set
Kardiologie Vinohrady s r o, Praha 1, Not set
Institute For Clinical And Experimental Medicine, Praha 4, Not set
Motol University Hospital, Praha 5, Not set
Fakultni Thomayerova nemocnice, Praha, Not set
Hospital Slany, Internal Department, Slany, Not set
Kardiologicka ambulance MUDr. Ferkl s.r.o., Trutnov, Not set
Clinical Trials Services s.r.o, Uherske Hradiste, Not set
Sygehus SonderJylland/ Sonderborg, Aabenraa, Not set
Bispebjerg og Frederiksberg Hospital, Copenhagen NV, Not set
Amager-Hvidovre Hospital, Copenhagen S, Not set
Rigshospitalet, Copenhagen, Not set
Herlev and Gentofte Hospital, Herlev, Not set
Holbæk Sygehus, Holbæk, Not set
Hvidovre Hospital, Hvidovre, Not set
Sjællands Universitetshospital, Roskilde, Not set
Slagelse Sygehus, Slagelse, Not set
Klinikum am Plattenwald, Bad Friedrichshall, Not set
Dres. Haas/Kirschner/Wagner, Bamberg, Not set
Vivantes Netzwerk für Gesundheit GmbH, Berlin, Not set
Charite Universitätsmedizin Berlin KöR, Berlin, Not set
GFO Kliniken Bonn, Bonn, Not set
Universitätsklinikum Bonn AöR, Bonn, Not set
SANA Kliniken Oberfranken Coburg GmbH, Coburg, Not set
Facharztzentrum Dresden-Neustadt Betriebsgesellschaft mbH, Dresden, Not set
Helios Klinikum Erfurt, Erfurt, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Universitätsklinikum Jena, Jena, Not set
Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Not set
Asklepios Klinik Langen-Seligenstadt GmbH, Langen, Not set
Klinikum der Stadt Ludwigshafen am Rhein GmbH, Ludwigshafen, Not set
Praxis Oedeme, Lüneburg, Not set
ze:roPRAXEN Fachinternistisches MVZ GmbH, Mannheim, Not set
Marienhaus Klinikum St. Elisabeth, Neuwied, Neuwied, Not set
Kardiologische Praxis Papenburg, Papenburg, Not set
Universitätsklinikum Regensburg, Regensburg, Not set
Gemeinschaftspraxis Dr. Josef Grosskopf und Dr. Wilma Grosskopf, Wallerfing, Not set
Kardiologische Praxis, Wermsdorf, Wermsdorf, Not set
Belgyogyaszati es Kardiologiai Maganrendelo, Bekescsaba, Not set
Buda Hospital of the Hospitaller Order of Saint John of God, Budapest, Not set
Obudai Egeszegugyi Centrum, Budapest, Not set
Belvaros-Lipotvaros Egeszsegugyi Szolgalat, Budapest, Not set
Gottsegen National Cardiovascular Center, Budapest, Not set
Semmelweis University, Budapest, Not set
Privat Doktor Egeszseguegyi Szolgaltato Zrt., Budapest, Not set
Zugloi Egeszsegugyi Szolgalat, Budapest, Not set
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz, Miskolc, Not set
IPR Hungary Kft., Miskolc, Not set
TaNa Med Kft., Mosonmagyarovar, Not set
Coromed-Smo Kft., Pecs, Not set
Tolna Varmegyei Balassa Janos Korhaz, Szekszard, Not set
Belvarosi Egeszseghaz Kft., Zalaegerszeg, Not set
Kamal Nayan Bajaj Hospital, Aurangabad, Not set
Narayana Institute of Cardiac Sciences, Bangalore, Not set
S.P. Medical College & Associated Group of Hospitals, Bikaner, Not set
Tamil Nadu Government Multi Super Speciality Hospital TNGMSSH, Chennai, Not set
Apollo Hospitals, Chennai, Not set
Medanta-The Medicity, Gurgaon, Not set
Lisie Hospital, Kochi, Not set
IPGMER and SSKM Hospital, Kolkata, Not set
Supe Heart & Diabetes Hospital & Research Centre, Nashik, Not set
Chopda Medicare and Research Centre Pvt Ltd, Nashik, Not set
Max Super Speciality Hospital, Delhi, New Delhi, Not set
Indira Gandhi Institute of Medical Sciences, Patna, Not set
Nirmal Hospital, Surat, Not set
Unicare Heart Institute, Surat, Not set
King George Hospital, Vishakhapatnam, Not set
Humanitas Gavazzeni, Bergamo, Not set
ASST Papa Giovanni XXIII, Bergamo, Not set
Az.Osp. Universitaria "Ospedali Riuniti", Foggia, Not set
Azienda Ospedaliera Universitaria "Federico II", Napoli, Not set
Fondazione IRCCS Policlinico S. Matteo, Pavia, Not set
Azienda Ospedaliera Universitaria Pisana, Pisa, Not set
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Hyogo Prefectural Amagasaki General Medical Center, Amagasaki-shi, Not set
Asahi General Hospital, Asahi-shi, Not set
Fukuokaken Saiseikai Futsukaichi Hospital, Fukuoka, Chikushino, Not set
Kyushu University Hospital, Fukuoka-shi, Not set
Gunma University Hospital, Gunma, Maebashi, Not set
Minamino Cardiovascular Hospital, Hachioji-shi, Not set
National Hospital Organization Hamada Medical Center, Hamada-shi, Not set
JA-Shizuoka Enshu Hospital, Hamamatsu-shi, Not set
Hyogo Prefectural Harima-Himeji General Medical Center, Himeji-shi, Not set
Hiratsuka Kyosai Hospital, Hiratsuka-shi, Not set
Hitachi Ltd. Hitachinaka General Hospital, Hitachinaka-shi, Not set
National Hospital Organization Kanazawa Medical Center, Ishikawa, Kanazawa, Not set
National Hospital Organization Iwakuni Clinical Center, Iwakuni-shi, Not set
Tokushukai Shonan Kamakura General Hospital, Kamakura-shi, Not set
Shonan Fujisawa Tokushukai Hospital, Kanagawa, Fujisawa, Not set
Tokushukai Hayama Heart Center, Kanagawa, Miura-gun, Not set
Mitoyo General Hospital, Kanonji-shi, Not set
Ibaraki Prefectural Central Hospital, Kasama-shi, Not set
Kasugai Municipal Hospital, Kasugai-shi, Not set
Saiseikai Kawaguchi Hospital, Kawaguchi-shi, Not set
St. Marianna University Hospital, Kawasaki-shi, Not set
Tokushukai Kishiwada Tokushukai Hospital, Kishiwada-shi, Not set
National Hospital Organization Kobe Medical Center, Kobe-shi, Not set
Kumamoto University Hospital, Kumamoto-shi, Not set
Japanese Red Cross Kumamoto Hospital, Kumamoto-shi, Not set
National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Not set
Chibanishi General Hospital, Matsudo-shi, Not set
Shinshu University Hospital, Matsumoto-shi, Not set
Ehime Prefectural Central Hospital, Matsuyama-shi, Not set
Matsuyama Shimin Hospital, Matsuyama-shi, Not set
National Hospital Organization Tokyo Medical Center, Meguro-ku, Not set
Mito Saiseikai General Hospital, Mito-shi, Not set
Tohoku University Hospital, Miyagi, Sendai, Not set
Sendai Cardiovascular Center, Miyagi, Sendai, Not set
Nagasaki Harbor Medical Center, Nagasaki, Nagasaki, Not set
Nagoya Kyoritsu Hospital, Nagoya-shi, Not set
Nagoya City University Hospital, Nagoya-shi, Not set
Hokushin General Hospital, Nakano-shi, Not set
Nara Medical University Hospital, Nara, Kashihara, Not set
Juzenkai The Sakakibara Heart Institute of Okayama, Okayama, Okayama, Not set
Ome Municipal General Hospital, Ome-shi, Not set
Nagasaki Medical Center, Omura-shi, Not set
Osaka Metropolitan University Hospital, Osaka-shi, Not set
Osaka General Medical Center, Osaka-shi, Not set
Kosekai Iwatsuki-minami Hospital, Saitama, Saitama, Not set
Osaka Rosai Hospital, Sakai-shi, Not set
Teine Keijinkai Hospital, Sapporo-shi, Not set
NHO Sendai Medical Center, Sendai-shi, Not set
NHO Kanmon Medical Center, Shimonoseki-shi, Not set
National Cerebral and Cardiovascular Center, Suita-shi, Not set
The University of Osaka Hospital, Suita-shi, Not set
Tachikawa Hospital, Tachikawa-shi, Not set
National Hospital Organization Takasaki General Medical Center, Takasaki-shi, Not set
NHO Minami Wakayama Medical Center, Tanabe-shi, Not set
Tokushima Prefectural Central Hospital, Tokushima-shi, Not set
Tomakomai City Hospital, Tomakomai-shi, Not set
Toyota Memorial Hospital, Toyota-shi, Not set
NHO Shinshu Ueda Medical Center, Ueda-shi, Not set
Yokohama Sakae Kyosai Hospital, Yokohama-shi, Not set
Inje University Busan Paik Hospital, Busan, Not set
Dong-A University Hospital, Busan, Not set
Pusan National University Yangsan Hospital, Busan, Not set
Chonnam National University Hospital, Gwangju, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam, Not set
Severance Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Korea University Anam Hospital, Seoul, Not set
Yonsei University Wonju Severance Christian Hospital, Wonju, Not set
Hospital Cardiologica Aguascalientes, Aguascalientes, Not set
Centro Especializado de Investigación Medical Group Culiacan, Culiacan, Not set
Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C., Culiacan, Not set
Cardiologia Clinica e Intervencionista, Guadalajara, Not set
Proactive CR Mexico S.A. de C.V., Irapuato, Not set
Centro de Estudios de Alta Especialidad de Sinaloa CEAES, Mazatlan, Not set
Cardiolink Clin Trials S.C., Monterrey, Not set
Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Not set
Clinstile S.A. de C.V., México, Not set
Centro de Estudios Clinicos de Queretaro S.C, Queretaro, Not set
Centro de Investigacion Cardiovascular y Metabolica, Tijuana, Not set
CIMAB S.A. de C.V., Torreon, Not set
Jeroen Bosch Ziekenhuis-Hertogenbosch, 's-HERTOGENBOSCH, Not set
Amsterdam University Medical Center, Amsterdam, Not set
Catharina Ziekenhuis, Eindhoven, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Maastricht University, Maastricht, Not set
St. Antonius ziekenhuis, locatie Nieuwegein, Nieuwegein, Not set
Isala Zwolle, Zwolle, Not set
American Heart Of Poland Sp. Z O.O., Bielsko-Biala, Not set
INTERCORE Medical Center, Bydgoszcz, Not set
Pratia Bydgoszcz Clinical Research Site, Bydgoszcz, Not set
NZOZ Medical Center KERmed, Bydgoszcz, Not set
Poradnia Kardiologiczna Jaroslaw Jurowiecki, Gdansk, Not set
Medical Centre Pratia Gdynia, Gdynia, Not set
Specjalistyczna Praktyka Lekarska Ewa Mirek-Bryniarska, Krakow, Not set
Linden Sp. z o.o. sp.k., Kraków, Not set
Pratia MCM Krakow, Kraków, Not set
Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j., Legnica, Not set
Santa Sp. z o.o. Santa Familia PTG Lodz, Lodz, Not set
Velocity Lublin, Lublin, Not set
Zanamed Medical Clinic Sp. z o.o., Lublin, Not set
NZOZ HEUREKA, Piaseczno, Piaseczno, Not set
CBK Med Clinic SP Z O O, Plock, Not set
MEDYK Medical Center, Rzeszow, Not set
Lukmed Lukasz Wozniak, Siedlce, Not set
Velocity Skierniewice Sp. z o.o, Skierniewice, Not set
Centrum Medyczne Pratia Poznan, Skórzewo, Not set
Velocity Staszow, Staszow, Not set
ETG Warszawa, Warsaw, Not set
Balsammedica Sp. z o. o., Warszawa, Not set
MTZ Clinical Research Powered by Pratia, Warszawa, Not set
4. Military Clinical Hospital with Polyclinic SP ZOZ, Wroclaw, Not set
Sedimed Sp. z o.o., Wroclaw, Not set
NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin, Zarow, Not set
Spitalul Judetean De Urgenta Dr. Constantin Opris Baia Mare, Baia Mare, Not set
Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu, Balotesti, Not set
Spitalul Judetean de Urgenta Braila, Braila, Not set
S.C.Centrul Medical Unirea S.R.L., Brasov, Not set
Spitalul Clinic Judetean de Urgenta Brasov, Brasov, Not set
Emergency University Hospital, Bucharest, Bucharest, Not set
Clinica Medicala Data Plus SRL, Bucuresti, Not set
Cluj Napoca Clinical County Hospital, Cluj-Napoca, Not set
Spitalul Angiocare SRL, Cluj-Napoca, Not set
Emergency County Hospital Craiova, Craiova, Not set
Spitalul Clinic Judetean de Urgenta Bihor, Oradea, Not set
Sal Med Srl, Pitesti, Not set
U 2 Serv Com Srl, Suceava, Not set
Cmi Dr. Podoleanu Cristian, Targu Mures, Not set
Spitalul Clinic Judetean de Urgenta Targu Mures, Targu Mures, Not set
Country Clinical Emergency Hospital, Targu-Mures, Targu-Mures, Not set
S.C Medicali's S.R.L, Timisoara, Not set
Timisoara Municipal Emergency Clinical Hospital, Timisoara, Not set
King AbdulAziz University Hospital, Al Ahsa, Not set
King Fahad Specialist Hospital - Research Center, Dammam, Not set
Imam Abdulrahman bin Faisal University, Dammam, Not set
King Faisal Specialist Hospital and Research Center, Riyadh, Not set
King Fahad Medical City, Riyadh, Not set
Clinical Center " Dr Dragisa Misovic Dedinje", Belgrade, Not set
University Clinical Center of Serbia, Belgrade, Not set
University Clinical Center of Kragujevac, Kragujevac, Not set
Institute for Treatment and Rehabilitation, Niska Banja, Niska Banja, Not set
University Clinical Center Nis, Nis, Not set
General Hospital Pancevo, Pancevo, Not set
General Hospital Sveti Luka, Smederevo, Not set
Institute of Cardiovascular Diseases of Vojvodine, Sremska Kamenica, Not set
Health Centre Zajecar, Zajecar, Not set
Kardiointerna s r o, Banska Bystrica, Not set
Stredoslovensky Ustav Srdcovych A Cievnych Chorob A S, Banska Bystrica, Not set
Alian s.r.o., Bardejov, Not set
Cliniq s.r.o., Bratislava, Not set
Nemocnica AGEL Zvolen a s, Bratislava, Not set
Premedix Clinic, Bratislava, Not set
Nemocnica s poliklinikou Brezno n.o., Brezno, Not set
Medical Group Kosice s.r.o, Kosice, Not set
KARDIO R s r o, Kosice, Not set
CARDIO D&R spol.s.r.o. Kosice, Kosice, Not set
KARDIO 1 s.r.o., Lucenec, Not set
Kardiomed s.r.o., Lucenec, Not set
Kvc-Kardiovaskularne Centrum, Martin, Not set
Cardiocenter Nitra, s.r.o, Nitra, Not set
Cardioamb s.r.o, Nove Zamky, Not set
Hospital Vall Hebron, Barcelona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital La Paz, Madrid, Not set
Hospital Virgen de la Victoria, Malaga, Not set
Hospital Virgen del Camino, Sanlucar de Barrameda, Not set
Complexo Hospitalario Universitario De Santiago, Santiago de Compostela, Not set
Pratia ES Hospital Universitario de Torrejon, Torrejón de Ardoz, Not set
Hospital Clínico de Valencia, Valencia, Not set
Hospital General Universitario de Valencia, Valencia, Not set
Hospital Politècnic La Fe, Valencia, Not set
Hospital Virgen de las Montañas, Villamartin, Villamartin, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
E-Da Hospital, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
Taipei Medical University Hospital, Taipei City, Not set
Taipei Veterans General Hospital, Taipei, Not set
Tri-Service General Hospital, Taipei, Not set
Chang-Hua Christian Hospital, Taipei, Not set
Cukurova Universitesi Tip Fakultesi Gog. Hast. Anabilim Dali, Adana, Not set
Etlik City Hospital, Ankara, Not set
Ataturk Universitesi Tip Fakultesi, Erzurum, Not set
Osmangazi Uni Medical Faculty, Eskisehir, Not set
Gaziantep University Medical Faculty Sahinbey Educational Research Hospital, Gaziantep, Not set
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, Istanbul, Not set
Medical Park Pendik Hospital, Istanbul, Not set
Dokuz Eylul University Faculty of Medicine, Izmir, Not set
Kutahya Health Science University, Kutahya, Not set
Inonu Uni. Med. Fac., Battalgazi, Malatya, Not set
Mersin University Medical Faculty, Mersin, Not set
Siyami Ersek Heart Hospital, Uskudar / Istanbul, Not set
Southmead Hospital, Bristol, Not set
Royal Devon and Exeter Hospital, Wonford, Exeter, Not set
Calderdale Royal Hospital, Halifax, Not set
St Bartholomew's Hospital, London, Not set
Hanoi Heart Hospital, Ha Noi, Not set
Bach Mai hospital, Hanoi, Not set
Tam Anh General Hospital, Hanoi, Not set
Nguyen Tri Phuong Hospital, Ho Chi Minh City, Not set
Tam Anh HCMC, Ho Chi Minh city, Not set
Military Hospital 175, Ho Chi Minh, Not set
Thong Nhat Hospital HCMC, Ho Chi Minh, Not set
Cho Ray Hospital, Ho Chi Minh, Not set
University Medical Center HCMC, Ho Chi Minh, Not set
Trung Vuong Hospital, Ho Chi Minh, Not set
Conditions: Heart Failure
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
Recruiting
The purpose of this randomized, double-blind, placebo-controlled, parallel group study is to determine the efficacy of frexalimab in delaying the disability progression and the safety up to 36 months double-blind administration of study intervention compared to placebo in male and female participants with nrSPMS (aged 18 to 60 years at the time of enrollment). People diagnosed with nrSPMS are eligible for enrollment as long as they meet all the inclusion criteria and none of the exclusion criter... Read More
The purpose of this randomized, double-blind, placebo-controlled, parallel group study is to determine the efficacy of frexalimab in delaying the disability progression and the safety up to 36 months double-blind administration of study intervention compared to placebo in male and female participants with nrSPMS (aged 18 to 60 years at the time of enrollment). People diagnosed with nrSPMS are eligible for enrollment as long as they meet all the inclusion criteria and none of the exclusion criteria. Study details include:
* This event-driven study will end when the target number of 6-month cCDP events is achieved, and the study is expected to last 43 months from randomization of the first participant to the common study end.
* The number of scheduled visits will be up to 25 (including 3 follow-up visits) with a visit frequency of every month for the first 6 months and then every 3 months. Read Less
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/21/2025
Locations: Alabama Neurology Associates- Site Number : 8400115, Homewood, Alabama +320 locations
Alabama Neurology Associates- Site Number : 8400115, Homewood, Alabama
St. Joseph's Hospital and Medical Center- Site Number : 8400139, Phoenix, Arizona
HonorHealth Neurology-Site Number : 8400074, Scottsdale, Arizona
Perseverance Research Center- Site Number : 8400138, Scottsdale, Arizona
Imaging Endpoints- Site Number : 8400050, Scottsdale, Arizona
Sutter East Bay Medical Foundation - Berkeley- Site Number : 8400134, Berkeley, California
The Neurology Center of Southern California - Carlsbad- Site Number : 8400023, Carlsbad, California
UC Irvine Healthcare - Gottschalk Medical Plaza- Site Number : 8400143, Irvine, California
University of California San Diego Site Number : 8400095, La Jolla, California
Southern California Permanente Medical Group- Site Number : 8400184, Los Angeles, California
Keck School of Medicine of University of Southern California- Site Number : 8400118, Los Angeles, California
Hoag Memorial Hospital Presbyterian- Site Number : 8400031, Newport Beach, California
Stanford Neuroscience Health Center- Site Number : 8400120, Palo Alto, California
Private Practice - Dr. Regina Berkovich- Site Number : 8400005, West Hollywood, California
University of Colorado- Site Number : 8400001, Denver, Colorado
Advanced Neurology of Colorado- Site Number : 8400148, Fort Collins, Colorado
Yale New Haven Hospital- Site Number : 8400081, New Haven, Connecticut
Hartford Healthcare Medical Group- Site Number : 8400069, Norwich, Connecticut
New England Institute for Clinical Research- Site Number : 8400114, Stamford, Connecticut
MedStar Georgetown University Hospital- Site Number : 8400044, Washington, District of Columbia
Neurology of Central Florida- Site Number : 8400147, Altamonte Springs, Florida
First Choice Neurology - Espinosa Neuroscience Institute- Site Number : 8400169, Boca Raton, Florida
Beth Israel Deaconess Medical Center- Site Number : 8400041, Fort Myers, Florida
University of Florida College of Medicine- Site Number : 8400054, Gainesville, Florida
Mayo Clinic Hospital Jacksonville- Site Number : 8400093, Jacksonville, Florida
Neurology Associates - Maitland- Site Number : 8400010, Maitland, Florida
MS & Neuromuscular Center of Excellence- Site Number : 8400015, Oldsmar, Florida
Orlando Health Neuroscience Institute- Site Number : 8400060, Orlando, Florida
Axiom Clinical Research of Florida- Site Number : 8400049, Tampa, Florida
University of South Florida- Site Number : 8400013, Tampa, Florida
Palm Beach Medical Group- Site Number : 8400105, West Palm Beach, Florida
Velocity Clinical Research - Savannah Neurology- Site Number : 8400061, Savannah, Georgia
Rush University Medical Center- Site Number : 8400102, Chicago, Illinois
University of Chicago Biological Science/Neurology (The) University of Chicago Medical Center)- Site Number : 8400055, Chicago, Illinois
Consultants in Neurology- Site Number : 8400020, Northbrook, Illinois
OSF Center for Health- Site Number : 8400030, Peoria, Illinois
Springfield Clinic 1st - 800 Building- Site Number : 8400043, Springfield, Illinois
Neuroscience Institute Center- Site Number : 8400053, Merrillville, Indiana
University of Iowa- Site Number : 8400029, Iowa City, Iowa
University of Kansas Medical Center- Site Number : 8400084, Kansas City, Kansas
College Park Family Care Center - Overland Park- Site Number : 8400032, Overland Park, Kansas
Baptist Health Lexington- Site Number : 8400149, Lexington, Kentucky
NeuroMedical Clinic of Central Louisiana- Site Number : 8400159, Alexandria, Louisiana
The NeuroMedical Center- Site Number : 8400182, Baton Rouge, Louisiana
Ochsner Medical Center - Jefferson Highway- Site Number : 8400027, New Orleans, Louisiana
University of Maryland, Baltimore- Site Number : 8400185, Baltimore, Maryland
Johns Hopkins Hospital- Site Number : 8400080, Baltimore, Maryland
International Neurorehabilitation Institute- Site Number : 8400089, Lutherville, Maryland
Tufts Medical Center- Site Number : 8400003, Boston, Massachusetts
Boston Clinical Trials- Site Number : 8400178, Boston, Massachusetts
Neurology Center of New England- Site Number : 8400164, Foxboro, Massachusetts
The Elliot Lewis Center- Site Number : 8400033, Wellesley, Massachusetts
UMass Memorial Medical Center- Site Number : 8400028, Worcester, Massachusetts
Henry Ford Hospital- Site Number : 8400091, Detroit, Michigan
Michigan Institute for Neurological Disorders- Site Number : 8400004, Farmington Hills, Michigan
Trinity Health Grand Rapids- Site Number : 8400150, Grand Rapids, Michigan
Memorial Healthcare Institute for Neuroscience- Site Number : 8400123, Owosso, Michigan
Rochester Medical Group- Site Number : 8400172, Rochester Hills, Michigan
Minneapolis Clinic of Neurology - Golden Valley- Site Number : 8400077, Golden Valley, Minnesota
University of Minnesota - Department of Neurology- Site Number : 8400056, Minneapolis, Minnesota
Minnesota Center for Multiple Sclerosis- Site Number : 8400073, Plymouth, Minnesota
Sharlin Health & Neurology- Site Number : 8400016, Ozark, Missouri
Washington University School of Medicine- Site Number : 8400076, Saint Louis, Missouri
Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas- Site Number : 8400045, Las Vegas, Nevada
Renown Regional Medical Center- Site Number : 8400066, Reno, Nevada
Dartmouth-Hitchcock Medical Center - Lebanon - 1 Medical Center Drive- Site Number : 8400098, Lebanon, New Hampshire
Rutgers University- Site Number : 8400067, New Brunswick, New Jersey
Holy Name Medical Center- Site Number : 8400101, Teaneck, New Jersey
University of New Mexico Comprehensive Cancer Center- Site Number : 8400090, Albuquerque, New Mexico
Dent Neurologic Institute - Amherst- Site Number : 8400129, Amherst, New York
Columbia University Medical Center - New York- Site Number : 8400088, New York, New York
Icahn School of Medicine at Mount Sinai- Site Number : 8400011, New York, New York
Stony Brook University- Site Number : 8400094, Stony Brook, New York
Piedmont HealthCare - Lake Norman Neurology- Site Number : 8400002, Charlotte, North Carolina
Raleigh Neurology Associates- Site Number : 8400014, Raleigh, North Carolina
Wake Forest Baptist Health- Site Number : 8400040, Winston-Salem, North Carolina
Sanford Neuroscience Clinic- Site Number : 8400085, Fargo, North Dakota
Riverhills Neuroscience- Site Number : 8400007, Cincinnati, Ohio
University of Cincinnati - Internal Medicine- Site Number : 8400117, Cincinnati, Ohio
The Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute- Site Number : 8400009, Columbus, Ohio
The Boster Center for Multiple Sclerosis- Site Number : 8400006, Columbus, Ohio
UC Health - Elizabeth Place- Site Number : 8400008, Dayton, Ohio
Oklahoma Medical Research Foundation- Site Number : 8400039, Oklahoma City, Oklahoma
Providence St. Vincent's Medical Center- Site Number : 8400052, Portland, Oregon
Penn State Health Milton South Hershey Medical Center- Site Number : 8400176, Hershey, Pennsylvania
Thomas Jefferson University Hospital- Site Number : 8400035, Philadelphia, Pennsylvania
Premier Neurology- Site Number : 8400047, Greer, South Carolina
Hope Neurology- Site Number : 8400019, Knoxville, Tennessee
Vanderbilt Multiple Sclerosis Center- Site Number : 8400130, Nashville, Tennessee
Neurology Consultants of Dallas - Lyndon B Johnson Freeway- Site Number : 8400152, Dallas, Texas
North Texas Institute of Neurology & Headache - Plano- Site Number : 8400083, Plano, Texas
Neurology Center of San Antonio- Site Number : 8400099, San Antonio, Texas
Texas Institute for Neurological Disorders - Sherman- Site Number : 8400018, Sherman, Texas
University of Vermont Medical Center- Site Number : 8400042, Burlington, Vermont
Inova Schar Cancer Institute - Fairfax - Innovation Park Drive- Site Number : 8400109, Fairfax, Virginia
Riverside Neurology Specialists - Newport News- Site Number : 8400132, Newport News, Virginia
Multiple Sclerosis Center of Greater Washington (MSCGW)- Site Number : 8400128, Vienna, Virginia
Swedish Medical Center- Site Number : 8400078, Seattle, Washington
West Virginia University School of Medicine- Site Number : 8400131, Morgantown, West Virginia
Wheaton Franciscan Healthcare - St Francis- Site Number : 8400034, Milwaukee, Wisconsin
Medical College of Wisconsin - Milwaukee Campus- Site Number : 8400038, Milwaukee, Wisconsin
Investigational Site Number : 0320003, Rosario, Santa Fe
Investigational Site Number : 0320002, Buenos Aires, Not set
Investigational Site Number : 0321010, Buenos Aires, Not set
Investigational Site Number : 0320007, Buenos Aires, Not set
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0360005, Saint Leonards, New South Wales
Investigational Site Number : 0360001, Woolloongabba, Queensland
Investigational Site Number : 0360002, Melbourne, Victoria
Investigational Site Number : 0560008, Brussels, Not set
Investigational Site Number : 0560006, Gent, Not set
Investigational Site Number : 0560007, Kortrijk, Not set
Investigational Site Number : 0560003, Melsbroek, Not set
Investigational Site Number : 0560005, Overpelt, Not set
Centro de Pesquisas da Clínica IBIS- Site Number : 0760030, Salvador, Bahia
L2IP - Instituto de Pesquisas Clínicas- Site Number : 0760003, Brasília, Distrito Federal
Universidade Federal de Goias- Site Number : 0760024, Goiânia, Goiás
Freire Pesquisa Clínica - Belo Horizonte - Rua Piauí- Site Number : 0760025, Belo Horizonte, Minas Gerais
Instituto de Neurologia de Curitiba - Ecoville- Site Number : 0760001, Curitiba, Paraná
Hospital Moinhos de Vento- Site Number : 0760005, Porto Alegre, Rio Grande Do Sul
Clínica Neurológica- Site Number : 0760007, Joinville, Santa Catarina
Prognosis Pesquisa Clinica- Site Number : 0760032, Santo Andre, São Paulo
CPQuali Pesquisa Clinica - São Paulo- Site Number : 0760002, São Paulo, Not set
PSEG Centro de Pesquisa Clínica- Site Number : 0760021, São Paulo, Not set
Jordy Sinapse- Site Number : 0760004, São Paulo, Not set
Investigational Site Number : 1000009, Blagoevgrad, Not set
Investigational Site Number : 1000008, Panagyurishte, Not set
Investigational Site Number : 1000007, Pazardzhik, Not set
Investigational Site Number : 1000002, Pleven, Not set
Investigational Site Number : 1000010, Pleven, Not set
Investigational Site Number : 1000004, Sofia, Not set
Investigational Site Number : 1000001, Sofia, Not set
Investigational Site Number : 1000006, Sofia, Not set
Investigational Site Number : 1000005, Sofia, Not set
Investigational Site Number : 1240011, Calgary, Alberta
Investigational Site Number : 1240005, Burnaby, British Columbia
Investigational Site Number : 1240010, Vancouver, British Columbia
Investigational Site Number : 1240015, North York, Ontario
Investigational Site Number : 1240002, Ottawa, Ontario
Investigational Site Number : 1240012, Toronto, Ontario
Investigational Site Number : 1240001, Gatineau, Quebec
Investigational Site Number : 1240008, Lévis, Quebec
Investigational Site Number : 1240009, Montreal, Quebec
Investigational Site Number : 1240016, Pointe-claire, Quebec
Investigational Site Number : 1240003, Quebec City, Quebec
Investigational Site Number : 1240006, Sherbrooke, Quebec
Investigational Site Number : 1520003, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520002, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520001, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1560007, Beijing, Not set
Investigational Site Number : 1560005, Beijing, Not set
Investigational Site Number : 1560008, Beijing, Not set
Investigational Site Number : 1560003, Changchun, Not set
Investigational Site Number : 1560011, Changsha, Not set
Investigational Site Number : 1560004, Chengdu, Not set
Investigational Site Number : 1560045, Fuzhou, Not set
Investigational Site Number : 1560002, Guangzhou, Not set
Investigational Site Number : 1561027, Harbin, Not set
Investigational Site Number : 1560010, Jiazhuang, Not set
Investigational Site Number : 1560001, Shanghai, Not set
Investigational Site Number : 1560006, Taiyuan, Not set
Investigational Site Number : 1560012, Tianjin, Not set
Investigational Site Number : 1560009, Wuhan, Not set
Investigational Site Number : 1560013, Xi An, Not set
Investigational Site Number : 1560034, Zhengzhou, Not set
Investigational Site Number : 2030011, Brno, Not set
Investigational Site Number : 2030005, Brno, Not set
Investigational Site Number : 2030002, Hradec Králové, Not set
Investigational Site Number : 2030006, Jihlava, Not set
Investigational Site Number : 2030007, Ostrava, Not set
Investigational Site Number : 2030003, Prague, Not set
Investigational Site Number : 2030004, Prague, Not set
Investigational Site Number : 2030008, Prague, Not set
Investigational Site Number : 2030009, Teplice, Not set
Investigational Site Number : 2030001, Zlín, Not set
Investigational Site Number : 2500011, Bron, Not set
Investigational Site Number : 2500005, Créteil, Not set
Investigational Site Number : 2500006, La Tronche, Not set
Investigational Site Number : 2500009, Lille, Not set
Investigational Site Number : 2500015, Montpellier, Not set
Investigational Site Number : 2500002, Nice, Not set
Investigational Site Number : 2500007, Paris, Not set
Investigational Site Number : 2500014, Paris, Not set
Investigational Site Number : 2500003, Rennes, Not set
Investigational Site Number : 2500010, Saint-herblain, Not set
Investigational Site Number : 2500001, Strasbourg, Not set
Investigational Site Number : 2760009, Bielefeld, Not set
Investigational Site Number : 2760010, Bochum, Not set
Investigational Site Number : 2760002, Düsseldorf, Not set
Investigational Site Number : 2760007, Jena, Not set
Investigational Site Number : 2760003, Leipzig, Not set
Investigational Site Number : 2760006, Münster, Not set
Investigational Site Number : 2760001, ULM, Not set
Investigational Site Number : 3000003, Athens, Not set
Investigational Site Number : 3000005, Athens, Not set
Investigational Site Number : 3000004, Ioannina, Not set
Investigational Site Number : 3000001, Larissa, Not set
Investigational Site Number : 3000002, Thessaloniki, Not set
Investigational Site Number : 3480003, Budapest, Not set
Investigational Site Number : 3480004, Budapest, Not set
Investigational Site Number : 3480006, Budapest, Not set
Investigational Site Number : 3480002, Gyor, Not set
Investigational Site Number : 3560017, Delhi, Not set
Investigational Site Number : 3560008, Hyderabad, Not set
Investigational Site Number : 3560005, Nashik, Not set
Investigational Site Number : 3560006, Shimla, Not set
Investigational Site Number : 3560004, Thiruvananthapuram, Not set
Investigational Site Number : 3800004, Florence, Firenze
Investigational Site Number : 3800011, Genoa, Genova
Investigational Site Number : 3800008, Pozzilli, Isernia
Investigational Site Number : 3800002, Milan, Milano
Investigational Site Number : 3800016, Milan, Milano
Investigational Site Number : 3800010, Naples, Napoli
Investigational Site Number : 3800006, Cefalù, Palermo
Investigational Site Number : 3800015, Rome, Roma
Investigational Site Number : 3800001, Rome, Roma
Investigational Site Number : 3800013, Rome, Roma
Investigational Site Number : 3800021, Rome, Roma
Investigational Site Number : 3800009, Bologna, Not set
Investigational Site Number : 3800014, Chieti, Not set
Investigational Site Number : 3800025, Ferrara, Not set
Investigational Site Number : 3800019, Foggia, Not set
Investigational Site Number : 3800026, Novara, Not set
Investigational Site Number : 3800017, Palermo, Not set
Investigational Site Number : 3800029, Parma, Not set
Investigational Site Number : 3800005, Pavia, Not set
Investigational Site Number : 3800030, Ravenna, Not set
Investigational Site Number : 3920003, Koriyama, Fukushima
Investigational Site Number : 3920014, Asahikawa, Hokkaido
Investigational Site Number : 3920007, Himeji, Hyogo
Investigational Site Number : 3920010, Sagamihara, Kanagawa
Investigational Site Number : 3920015, Higashimatsuyama, Saitama
Investigational Site Number : 3920016, Kodaira, Tokyo
Investigational Site Number : 3920002, Chiba, Not set
Investigational Site Number : 3920013, Fukuoka, Not set
Investigational Site Number : 3920001, Kyoto, Not set
Investigational Site Number : 3920011, Tokyo, Not set
Investigational Site Number : 3920012, Tokyo, Not set
Investigational Site Number : 4100001, Goyang-si, Gyeonggi-do
Investigational Site Number : 4100007, Seongnam-si, Gyeonggi-do
Investigational Site Number : 4100002, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100004, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100003, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 5280002, Rotterdam, Not set
Investigational Site Number : 5280001, Sittard-geleen, Not set
Investigational Site Number : 6160005, Krakow, Malopolskie
Investigational Site Number : 6160006, Rzeszow, Podkarpackie
Investigational Site Number : 6160007, Bialystok, Podlaskie
Investigational Site Number : 6160010, Katowice, Slaskie
Investigational Site Number : 6160011, Katowice, Slaskie
Investigational Site Number : 6160002, Plewiska, Wielkopolskie
Investigational Site Number : 6160012, Poznan, Wielkopolskie
Investigational Site Number : 6200001, Braga, Not set
Investigational Site Number : 6200011, Lisbon, Not set
Investigational Site Number : 6200007, Lisbon, Not set
Investigational Site Number : 6200006, Lisbon, Not set
Investigational Site Number : 6200002, Matosinhos, Not set
San Juan MS Center- Site Number : 8400106, Guaynabo, Not set
Investigational Site Number : 7240018, Murcia, Almería
Investigational Site Number : 7240016, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240010, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240011, L'hospitalet de Llobregat, Catalunya [Cataluña]
Investigational Site Number : 7240012, Donostia-san Sebastian, Gipuzkoa
Investigational Site Number : 7240024, Girona, Girona [Gerona]
Investigational Site Number : 7240013, Las Palmas de Gran Canaria, Las Palmas
Investigational Site Number : 7240015, Lleida, Lleida [Lérida]
Investigational Site Number : 7240017, Majadahonda, Madrid
Investigational Site Number : 7240001, Pozuelo de Alarcón, Madrid
Investigational Site Number : 7240009, Barakaldo, Pais Vasco
Investigational Site Number : 7240014, Pontevedra, Pontevedra [Pontevedra]
Investigational Site Number : 7240007, Seville, Sevilla
Investigational Site Number : 7240004, Córdoba, Not set
Investigational Site Number : 7240006, Madrid, Not set
Investigational Site Number : 7240023, Madrid, Not set
Investigational Site Number : 7240002, Madrid, Not set
Investigational Site Number : 7240003, Madrid, Not set
Investigational Site Number : 7240022, Madrid, Not set
Investigational Site Number : 7240005, Málaga, Not set
Investigational Site Number : 7240008, Valencia, Not set
Investigational Site Number : 7520001, Gothenburg, Not set
Investigational Site Number : 7520005, Huddinge, Not set
Investigational Site Number : 7520003, Malmö, Not set
Investigational Site Number : 7520002, Stockholm, Not set
Investigational Site Number : 7920018, Ankara, Not set
Investigational Site Number : 7920011, Ankara, Not set
Investigational Site Number : 7920020, Bursa, Not set
Investigational Site Number : 7920013, Bursa, Not set
Investigational Site Number : 7920005, Eskişehir, Not set
Investigational Site Number : 7920012, Istanbul, Not set
Investigational Site Number : 7920002, Istanbul, Not set
Investigational Site Number : 7920016, Istanbul, Not set
Investigational Site Number : 7920009, Istanbul, Not set
Investigational Site Number : 7920007, Istanbul, Not set
Investigational Site Number : 7920019, Izmir, Not set
Investigational Site Number : 7920008, Izmir, Not set
Investigational Site Number : 7920001, Izmit, Not set
Investigational Site Number : 7920014, Kayseri, Not set
Investigational Site Number : 7920015, Konya, Not set
Investigational Site Number : 7920006, Mersin, Not set
Investigational Site Number : 7920004, Samsun, Not set
Investigational Site Number : 7920003, Sultangazi, Not set
Investigational Site Number : 7920017, VAN, Not set
Investigational Site Number : 8040001, Chernivtsi, Not set
Investigational Site Number : 8040009, Ivano-frankivsk, Not set
Investigational Site Number : 8040003, Krykhivtsi, Not set
Investigational Site Number : 8040006, Kyiv, Not set
Investigational Site Number : 8040008, Lutsk, Not set
Investigational Site Number : 8040004, Lviv, Not set
Investigational Site Number : 8040002, Lviv, Not set
Investigational Site Number : 8040005, Vinnytsia, Not set
Investigational Site Number : 8260011, Gwent, Blaenau Gwent
Investigational Site Number : 8260007, Cardiff, Cardiff [Caerdydd Gb-crd]
Investigational Site Number : 8260001, Exeter, Devon
Investigational Site Number : 8260013, London, England
Investigational Site Number : 8260006, Newcastle Upon Tyne, England
Investigational Site Number : 8260003, Canterbury, Kent
Investigational Site Number : 8260008, Salford, Manchester
Investigational Site Number : 8260004, Oxford, Oxfordshire
Investigational Site Number : 8260005, Swansea, Swansea [Abertawe Gb-ata]
Investigational Site Number : 8260010, Inverness, Not set
Investigational Site Number : 8260009, Liverpool, Not set
Conditions: Multiple Sclerosis
A Trial of Lu AF82422 in Participants With Multiple System Atrophy (MSA)
Recruiting
The main goal of this trial is to evaluate the efficacy and safety of Lu AF82422 for the treatment of participants with Multiple System Atrophy (MSA).
The main goal of this trial is to evaluate the efficacy and safety of Lu AF82422 for the treatment of participants with Multiple System Atrophy (MSA). Read Less
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
08/21/2025
Locations: Mayo Clinic, Scottsdale, Arizona +57 locations
Mayo Clinic, Scottsdale, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
University of California, San Francisco Neurosciences Clinical Research Unit, San Francisco, California
CenExel Rocky Mountain Clinical Research, LLC, Englewood, Colorado
Yale New Haven Health, North Haven, Connecticut
Parkinson's Disease And Movement Disorder Center Of Boca Raton, Boca Raton, Florida
University of Florida Norman Fixel Institute for Neurological Diseases, Gainesville, Florida
Indiana Health University, Indianapolis, Indiana
QUEST Research Institute, Farmington Hills, Michigan
Mayo Clinic, Rochester, Minnesota
University Nebraska Medical Center, Omaha, Nebraska
Columbia University Medical Center - The Neurological Institute of New York, New York, New York
Cleveland Clinic - Neurological Institute, Cleveland, Ohio
University of Pennsylvania, Philadelphia, Pennsylvania
University Of Pittsburgh, Pittsburgh, Pennsylvania
Vanderbilt University Medical Center-Cognitive and Movement Disorders Group, Nashville, Tennessee
Baylor College Of Medicine, Houston, Texas
Inland Northwest Research, Spokane, Washington
Liverpool Hospital - South Western Sydney Local Health District, Liverpool, New South Wales
Westmead Hospital, Westmead, New South Wales
Gold Coast Hospital, Southport, Queensland
The Alfred Hospital, Melbourne, Victoria
Centre Hospitalier Universitaire (CHU) de Bordeaux - Groupe Hospitalier Pellegrin, Bordeaux, Not set
Centre Hospitalier Regional Universitaire de Lille - Hopital Roger Salengro, Lille, Not set
Centre Hospitalier Regional Universitaire (CHRU) Montpellier - Hopital Saint-Eloi Guy de Chauliac, Montpellier, Not set
Chu De La Pitie-Salpetriere, Paris, Not set
Centre Hospitalier Universitaire de Toulouse - Hopital Purpan, Toulouse, Not set
Movement Disorders Clinic, Beelitz-Heilstatten, Not set
Universitaetsklinikum Erlangen, Erlangen, Not set
Curiositas-ad-sanum Beratungs-und Studien GmbH, Haag in Oberbayern, Not set
University Hospital Tuebingen, Tuebingen, Not set
IRCCS Institute of Neurological Sciences of Bologna- Universita di Bologna, Bologna, Not set
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Not set
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Not set
A.O.U. Pisana-Ospedale S. Chiara, Pisa, Not set
Universita Di Salerno Aou San Giovanni Di Dio E Ruggi D'Aragona, Salerno, Not set
Gifu University Hospital, Gifu City, Gifu
Hokkaido University Hospital, Sapporo, Hokkaido
National Hospital Organization Sendai Nishitaga Hospital, Sendai, Miyagi
Juntendo University Hospital, Bunkyo-ku, Tokyo
National Center Hospital, National Center of Neurology and Psychiatry, Kodaira-shi, Tokyo
Tottori University Hospital, Yonago-shi, Tottori
Saitama Medical University Hospital, Iruma-gun, Not set
Niigata University Medical And Dental Hospital, Niigata, Not set
Keio University Hospital, Tokyo, Not set
Kyung Hee University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona (Spain), Not set
Hospital Universitario Vall d'Hebron, Barcelona, Not set
Hospital Clinic de Barcelona - Institut Clinic de Neurociencies (ICN), Barcelona, Not set
Hospital Universitario de La Princesa, Madrid, Not set
Hospital Universitario Virgen del Rocio (HUVR) - Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Not set
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bu..., Valencia, Not set
Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, Greater Manchester
Queen Elizabeth University Hospital - NHS Greater Glasgow & Clyde, Glasgow, Scotland
Clinical Ageing Reseach Unit, Newcastle upon Tyne, Tyne And Wear
The National Hospital for Neurology and Neurosurgery, London, Not set
Conditions: Multiple System Atrophy
A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib
Recruiting
This is a Phase 3, 2-arm, randomized, open-label, global, multicenter study comparing the efficacy of ripretinib to sunitinib in participants with GIST who progressed on first-line treatment with imatinib, harbor co-occurring KIT exons 11+17/18 mutations, and are without KIT exon 9, 13, or 14 mutations. Upon disease progression as determined by an independent radiologic review, participants randomized to sunitinib will be given the option to either crossover to receive ripretinib 150 mg QD or di... Read More
This is a Phase 3, 2-arm, randomized, open-label, global, multicenter study comparing the efficacy of ripretinib to sunitinib in participants with GIST who progressed on first-line treatment with imatinib, harbor co-occurring KIT exons 11+17/18 mutations, and are without KIT exon 9, 13, or 14 mutations. Upon disease progression as determined by an independent radiologic review, participants randomized to sunitinib will be given the option to either crossover to receive ripretinib 150 mg QD or discontinue sunitinib. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: UC San Diego Moores Cancer Center, La Jolla, California +64 locations
UC San Diego Moores Cancer Center, La Jolla, California
Yale University, New Haven, Connecticut
Mayo Clinic Florida, Jacksonville, Florida
Sylvester Comprehensive Cancer Center, Miami, Florida
Moffitt Cancer Center, Tampa, Florida
Johns Hopkins Hospital, Baltimore, Maryland
Boston Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
M Health Fairview University of Minnesota Medical Center, Minneapolis, Minnesota
Mayo Clinic, Rochester, Minnesota
Memorial Sloan Kettering Cancer Center, New York, New York
Northwell Health Cancer Institute/ R.J. Zuckerberg Cancer Center, New York, New York
Cleveland Clinic, Cleveland, Ohio
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio
OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma
Oregon Health & Science University, Portland, Oregon
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
The University of Texas MD Anderson Cancer Center, Houston, Texas
Fred Hutchinson Cancer Center, Seattle, Washington
Prince of Wales Hospital, Randwick, New South Wales
Alfred Health, Melbourne, Victoria
CEPEN - Centro de Pesquisa e Ensino em Saude de Santa Catarina, Florianópolis, Santa Catarina
Hospital de Cancer de Barretos - Fundacao Pio XII, Barretos, Sao Paulo
Hospital Sirio-Libanes, São Paulo, Sao Paulo
Hospital 9 de Julho, São Paulo, SP
INCA - Instituto Nacional de Cancer, Rio De Janeiro, Not set
AC Camargo Câncer Center, São Paulo, Not set
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
Juravinski Cancer Centre, Hamilton, Ontario
University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario
McGill University Health Centre, Montréal, Quebec
Clínica San Carlos De Apoquindo Red Salud UC Christus, Las Condes, RM
Centro de Oncología de Precisión, Santiago, RM
CHU Dijon, Dijon Cedex, Bourgogone
Centre Eugène Marquis, Rennes, Ille et Vilaine
Institut Bergonié, Bordeaux, Not set
Centre Léon Bérard, Lyon, Not set
Institut Gustave Roussy, Villejuif, Not set
Helios Klinikum Berlin-Buch, Berlin, Not set
University Hospital Essen (Universitätsklinikum Essen), Essen, Not set
Universitares Krebszentrum Leipzig, Leipzig, Not set
Istituto Nazionale Tumori IRCCS Fondazione "G Pascale", Naples, Napoli
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi, Bologna, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Not set
Istituto Oncologico Veneto-IOV IRCCS, Padova, Not set
U.O.C. Oncologia Medica, Palermo, Not set
Università Campus Bio-Medico di Roma, Roma, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
UMC Groningen, Groningen, Not set
LUMC, Leiden, Not set
Oslo University Hospital, Oslo, Not set
Narodowy Instytut Onkologii Im . Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw, Warszawa
Complejo Hospitalario Universitario de Vigo - Hospital Alvaro Cunqueiro, Vigo, Pontevedra
Hospital Universitario Vall d'Hebron, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Instituto Valenciano de Oncologia - IVO, Valencia, Not set
China Medical University Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
The Royal Marsden Hospital NHS Foundation Trust, London, Greater London
St. James University Hospital, Leeds, West Yorkshire
Conditions: GIST
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