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All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Recruiting
Participants in this study have a genetic mutation, specifically in the coagulation (blood clotting) Factor 9 gene that causes severe or moderately severe hemophilia B. This study is researching an experimental gene insertion therapy (the adding of a gene into your DNA) called REGV131-LNP1265, also called the "study drug". Gene insertion therapy aims to teach the body how to produce clotting factor long-term, without the need for factor replacement therapy.
The main aim of this study is to find... Read More
Participants in this study have a genetic mutation, specifically in the coagulation (blood clotting) Factor 9 gene that causes severe or moderately severe hemophilia B. This study is researching an experimental gene insertion therapy (the adding of a gene into your DNA) called REGV131-LNP1265, also called the "study drug". Gene insertion therapy aims to teach the body how to produce clotting factor long-term, without the need for factor replacement therapy.
The main aim of this study is to find a safe and well-tolerated dose of the study drug by checking the side effects that may happen from taking it.
The study is looking at several other research questions including:
* How much study drug is in the blood at different times
* Whether the body makes antibodies against parts of the study drug, which could make the drug less effective or could lead to side effects. Antibodies are proteins produced by the body's immune system in response to a foreign substance
* Whether the body makes antibodies against the clotting factor replacement therapy
* How quality of life is affected by hemophilia B and if it changes after taking study drug
* How joint health is affected by hemophilia B and if it changes after taking study drug
* How often visits are required for the emergency room, urgent care center, physician's office, hospital, telephone or online are required as a result of bleeding events, and if the frequency changes after taking study drug
* How often factor replacement therapy is needed, both on a regular basis for prevention of bleeding, and as needed to treat bleeding events (and it if changes after taking study drug)
* Whether there is a difference in 2 different methods for measuring Factor 9 activity in the blood Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Orthopaedic Hemophilia Treatment Center, Los Angeles, California +21 locations
Orthopaedic Hemophilia Treatment Center, Los Angeles, California
David Geffen School of Medicine at UCLA, Los Angeles, California
Children's Hospital Los Angeles, Los Angeles, California
University of California Davis, Sacramento, California
University California San Francisco, San Francisco, California
Yale HTC, New Haven, Connecticut
Tulane University School of Medicine, Louisiana Center for Bleeding and Clotting Disorders, New Orleans, Louisiana
University of Michigan, Ann Arbor, Michigan
Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania
McMaster University Medical Centre - Hamilton Health Sciences, Hamilton, Ontario
Hopital Necker, Paris, Ile-de-France
Hospices Civils de Lyon, Bron, Lyon
University Hospital Frankfurt, Frankfurt, Hesse
Hospital Universitario Central de Asturias, Oviedo, Asturias
Complejo Hospitalario Universitario de A Coruna, A Coruna, Galicia
Hospital Clinico Universitario Virgen De La Arrixaca, El Palmar, Murcia
Hospital Universitario Miguel Servet, Zaragoza, Not set
Glasgow Royal Infirmary - Clinical Research Facility, Glasgow, Scotland
Addenbrooke's Hospital, Cambridge University Hospitals NHS FT, Cambridge, Not set
Royal Free London NHS Foundation Trust, London, Not set
St. Thomas' Hospital, London, Not set
Hammersmith Hospital Comprehensive Care Centre, London, Not set
Conditions: Hemophilia B
A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib
Recruiting
This is a Phase 3, 2-arm, randomized, open-label, global, multicenter study comparing the efficacy of ripretinib to sunitinib in participants with GIST who progressed on first-line treatment with imatinib, harbor co-occurring KIT exons 11+17/18 mutations, and are without KIT exon 9, 13, or 14 mutations. Upon disease progression as determined by an independent radiologic review, participants randomized to sunitinib will be given the option to either crossover to receive ripretinib 150 mg QD or di... Read More
This is a Phase 3, 2-arm, randomized, open-label, global, multicenter study comparing the efficacy of ripretinib to sunitinib in participants with GIST who progressed on first-line treatment with imatinib, harbor co-occurring KIT exons 11+17/18 mutations, and are without KIT exon 9, 13, or 14 mutations. Upon disease progression as determined by an independent radiologic review, participants randomized to sunitinib will be given the option to either crossover to receive ripretinib 150 mg QD or discontinue sunitinib. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: UC San Diego Moores Cancer Center, La Jolla, California +64 locations
UC San Diego Moores Cancer Center, La Jolla, California
Yale University, New Haven, Connecticut
Mayo Clinic Florida, Jacksonville, Florida
Sylvester Comprehensive Cancer Center, Miami, Florida
Moffitt Cancer Center, Tampa, Florida
Johns Hopkins Hospital, Baltimore, Maryland
Boston Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
M Health Fairview University of Minnesota Medical Center, Minneapolis, Minnesota
Mayo Clinic, Rochester, Minnesota
Memorial Sloan Kettering Cancer Center, New York, New York
Northwell Health Cancer Institute/ R.J. Zuckerberg Cancer Center, New York, New York
Cleveland Clinic, Cleveland, Ohio
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio
OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma
Oregon Health & Science University, Portland, Oregon
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
The University of Texas MD Anderson Cancer Center, Houston, Texas
Fred Hutchinson Cancer Center, Seattle, Washington
Prince of Wales Hospital, Randwick, New South Wales
Alfred Health, Melbourne, Victoria
CEPEN - Centro de Pesquisa e Ensino em Saude de Santa Catarina, Florianópolis, Santa Catarina
Hospital de Cancer de Barretos - Fundacao Pio XII, Barretos, Sao Paulo
Hospital Sirio-Libanes, São Paulo, Sao Paulo
Hospital 9 de Julho, São Paulo, SP
INCA - Instituto Nacional de Cancer, Rio De Janeiro, Not set
AC Camargo Câncer Center, São Paulo, Not set
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
Juravinski Cancer Centre, Hamilton, Ontario
University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario
McGill University Health Centre, Montréal, Quebec
Clínica San Carlos De Apoquindo Red Salud UC Christus, Las Condes, RM
Centro de Oncología de Precisión, Santiago, RM
CHU Dijon, Dijon Cedex, Bourgogone
Centre Eugène Marquis, Rennes, Ille et Vilaine
Institut Bergonié, Bordeaux, Not set
Centre Léon Bérard, Lyon, Not set
Institut Gustave Roussy, Villejuif, Not set
Helios Klinikum Berlin-Buch, Berlin, Not set
University Hospital Essen (Universitätsklinikum Essen), Essen, Not set
Universitares Krebszentrum Leipzig, Leipzig, Not set
Istituto Nazionale Tumori IRCCS Fondazione "G Pascale", Naples, Napoli
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi, Bologna, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Not set
Istituto Oncologico Veneto-IOV IRCCS, Padova, Not set
U.O.C. Oncologia Medica, Palermo, Not set
Università Campus Bio-Medico di Roma, Roma, Not set
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
UMC Groningen, Groningen, Not set
LUMC, Leiden, Not set
Oslo University Hospital, Oslo, Not set
Narodowy Instytut Onkologii Im . Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw, Warszawa
Complejo Hospitalario Universitario de Vigo - Hospital Alvaro Cunqueiro, Vigo, Pontevedra
Hospital Universitario Vall d'Hebron, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Instituto Valenciano de Oncologia - IVO, Valencia, Not set
China Medical University Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
The Royal Marsden Hospital NHS Foundation Trust, London, Greater London
St. James University Hospital, Leeds, West Yorkshire
Conditions: GIST
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
Recruiting
The purpose of this randomized, double-blind, placebo-controlled, parallel group study is to determine the efficacy of frexalimab in delaying the disability progression and the safety up to 36 months double-blind administration of study intervention compared to placebo in male and female participants with nrSPMS (aged 18 to 60 years at the time of enrollment). People diagnosed with nrSPMS are eligible for enrollment as long as they meet all the inclusion criteria and none of the exclusion criter... Read More
The purpose of this randomized, double-blind, placebo-controlled, parallel group study is to determine the efficacy of frexalimab in delaying the disability progression and the safety up to 36 months double-blind administration of study intervention compared to placebo in male and female participants with nrSPMS (aged 18 to 60 years at the time of enrollment). People diagnosed with nrSPMS are eligible for enrollment as long as they meet all the inclusion criteria and none of the exclusion criteria. Study details include:
* This event-driven study will end when the target number of 6-month cCDP events is achieved, and the study is expected to last 43 months from randomization of the first participant to the common study end.
* The number of scheduled visits will be up to 25 (including 3 follow-up visits) with a visit frequency of every month for the first 6 months and then every 3 months. Read Less
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/21/2025
Locations: Alabama Neurology Associates- Site Number : 8400115, Homewood, Alabama +320 locations
Alabama Neurology Associates- Site Number : 8400115, Homewood, Alabama
St. Joseph's Hospital and Medical Center- Site Number : 8400139, Phoenix, Arizona
HonorHealth Neurology-Site Number : 8400074, Scottsdale, Arizona
Perseverance Research Center- Site Number : 8400138, Scottsdale, Arizona
Imaging Endpoints- Site Number : 8400050, Scottsdale, Arizona
Sutter East Bay Medical Foundation - Berkeley- Site Number : 8400134, Berkeley, California
The Neurology Center of Southern California - Carlsbad- Site Number : 8400023, Carlsbad, California
UC Irvine Healthcare - Gottschalk Medical Plaza- Site Number : 8400143, Irvine, California
University of California San Diego Site Number : 8400095, La Jolla, California
Southern California Permanente Medical Group- Site Number : 8400184, Los Angeles, California
Keck School of Medicine of University of Southern California- Site Number : 8400118, Los Angeles, California
Hoag Memorial Hospital Presbyterian- Site Number : 8400031, Newport Beach, California
Stanford Neuroscience Health Center- Site Number : 8400120, Palo Alto, California
Private Practice - Dr. Regina Berkovich- Site Number : 8400005, West Hollywood, California
University of Colorado- Site Number : 8400001, Denver, Colorado
Advanced Neurology of Colorado- Site Number : 8400148, Fort Collins, Colorado
Yale New Haven Hospital- Site Number : 8400081, New Haven, Connecticut
Hartford Healthcare Medical Group- Site Number : 8400069, Norwich, Connecticut
New England Institute for Clinical Research- Site Number : 8400114, Stamford, Connecticut
MedStar Georgetown University Hospital- Site Number : 8400044, Washington, District of Columbia
Neurology of Central Florida- Site Number : 8400147, Altamonte Springs, Florida
First Choice Neurology - Espinosa Neuroscience Institute- Site Number : 8400169, Boca Raton, Florida
Beth Israel Deaconess Medical Center- Site Number : 8400041, Fort Myers, Florida
University of Florida College of Medicine- Site Number : 8400054, Gainesville, Florida
Mayo Clinic Hospital Jacksonville- Site Number : 8400093, Jacksonville, Florida
Neurology Associates - Maitland- Site Number : 8400010, Maitland, Florida
MS & Neuromuscular Center of Excellence- Site Number : 8400015, Oldsmar, Florida
Orlando Health Neuroscience Institute- Site Number : 8400060, Orlando, Florida
Axiom Clinical Research of Florida- Site Number : 8400049, Tampa, Florida
University of South Florida- Site Number : 8400013, Tampa, Florida
Palm Beach Medical Group- Site Number : 8400105, West Palm Beach, Florida
Velocity Clinical Research - Savannah Neurology- Site Number : 8400061, Savannah, Georgia
Rush University Medical Center- Site Number : 8400102, Chicago, Illinois
University of Chicago Biological Science/Neurology (The) University of Chicago Medical Center)- Site Number : 8400055, Chicago, Illinois
Consultants in Neurology- Site Number : 8400020, Northbrook, Illinois
OSF Center for Health- Site Number : 8400030, Peoria, Illinois
Springfield Clinic 1st - 800 Building- Site Number : 8400043, Springfield, Illinois
Neuroscience Institute Center- Site Number : 8400053, Merrillville, Indiana
University of Iowa- Site Number : 8400029, Iowa City, Iowa
University of Kansas Medical Center- Site Number : 8400084, Kansas City, Kansas
College Park Family Care Center - Overland Park- Site Number : 8400032, Overland Park, Kansas
Baptist Health Lexington- Site Number : 8400149, Lexington, Kentucky
NeuroMedical Clinic of Central Louisiana- Site Number : 8400159, Alexandria, Louisiana
The NeuroMedical Center- Site Number : 8400182, Baton Rouge, Louisiana
Ochsner Medical Center - Jefferson Highway- Site Number : 8400027, New Orleans, Louisiana
University of Maryland, Baltimore- Site Number : 8400185, Baltimore, Maryland
Johns Hopkins Hospital- Site Number : 8400080, Baltimore, Maryland
International Neurorehabilitation Institute- Site Number : 8400089, Lutherville, Maryland
Tufts Medical Center- Site Number : 8400003, Boston, Massachusetts
Boston Clinical Trials- Site Number : 8400178, Boston, Massachusetts
Neurology Center of New England- Site Number : 8400164, Foxboro, Massachusetts
The Elliot Lewis Center- Site Number : 8400033, Wellesley, Massachusetts
UMass Memorial Medical Center- Site Number : 8400028, Worcester, Massachusetts
Henry Ford Hospital- Site Number : 8400091, Detroit, Michigan
Michigan Institute for Neurological Disorders- Site Number : 8400004, Farmington Hills, Michigan
Trinity Health Grand Rapids- Site Number : 8400150, Grand Rapids, Michigan
Memorial Healthcare Institute for Neuroscience- Site Number : 8400123, Owosso, Michigan
Rochester Medical Group- Site Number : 8400172, Rochester Hills, Michigan
Minneapolis Clinic of Neurology - Golden Valley- Site Number : 8400077, Golden Valley, Minnesota
University of Minnesota - Department of Neurology- Site Number : 8400056, Minneapolis, Minnesota
Minnesota Center for Multiple Sclerosis- Site Number : 8400073, Plymouth, Minnesota
Sharlin Health & Neurology- Site Number : 8400016, Ozark, Missouri
Washington University School of Medicine- Site Number : 8400076, Saint Louis, Missouri
Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas- Site Number : 8400045, Las Vegas, Nevada
Renown Regional Medical Center- Site Number : 8400066, Reno, Nevada
Dartmouth-Hitchcock Medical Center - Lebanon - 1 Medical Center Drive- Site Number : 8400098, Lebanon, New Hampshire
Rutgers University- Site Number : 8400067, New Brunswick, New Jersey
Holy Name Medical Center- Site Number : 8400101, Teaneck, New Jersey
University of New Mexico Comprehensive Cancer Center- Site Number : 8400090, Albuquerque, New Mexico
Dent Neurologic Institute - Amherst- Site Number : 8400129, Amherst, New York
Columbia University Medical Center - New York- Site Number : 8400088, New York, New York
Icahn School of Medicine at Mount Sinai- Site Number : 8400011, New York, New York
Stony Brook University- Site Number : 8400094, Stony Brook, New York
Piedmont HealthCare - Lake Norman Neurology- Site Number : 8400002, Charlotte, North Carolina
Raleigh Neurology Associates- Site Number : 8400014, Raleigh, North Carolina
Wake Forest Baptist Health- Site Number : 8400040, Winston-Salem, North Carolina
Sanford Neuroscience Clinic- Site Number : 8400085, Fargo, North Dakota
Riverhills Neuroscience- Site Number : 8400007, Cincinnati, Ohio
University of Cincinnati - Internal Medicine- Site Number : 8400117, Cincinnati, Ohio
The Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute- Site Number : 8400009, Columbus, Ohio
The Boster Center for Multiple Sclerosis- Site Number : 8400006, Columbus, Ohio
UC Health - Elizabeth Place- Site Number : 8400008, Dayton, Ohio
Oklahoma Medical Research Foundation- Site Number : 8400039, Oklahoma City, Oklahoma
Providence St. Vincent's Medical Center- Site Number : 8400052, Portland, Oregon
Penn State Health Milton South Hershey Medical Center- Site Number : 8400176, Hershey, Pennsylvania
Thomas Jefferson University Hospital- Site Number : 8400035, Philadelphia, Pennsylvania
Premier Neurology- Site Number : 8400047, Greer, South Carolina
Hope Neurology- Site Number : 8400019, Knoxville, Tennessee
Vanderbilt Multiple Sclerosis Center- Site Number : 8400130, Nashville, Tennessee
Neurology Consultants of Dallas - Lyndon B Johnson Freeway- Site Number : 8400152, Dallas, Texas
North Texas Institute of Neurology & Headache - Plano- Site Number : 8400083, Plano, Texas
Neurology Center of San Antonio- Site Number : 8400099, San Antonio, Texas
Texas Institute for Neurological Disorders - Sherman- Site Number : 8400018, Sherman, Texas
University of Vermont Medical Center- Site Number : 8400042, Burlington, Vermont
Inova Schar Cancer Institute - Fairfax - Innovation Park Drive- Site Number : 8400109, Fairfax, Virginia
Riverside Neurology Specialists - Newport News- Site Number : 8400132, Newport News, Virginia
Multiple Sclerosis Center of Greater Washington (MSCGW)- Site Number : 8400128, Vienna, Virginia
Swedish Medical Center- Site Number : 8400078, Seattle, Washington
West Virginia University School of Medicine- Site Number : 8400131, Morgantown, West Virginia
Wheaton Franciscan Healthcare - St Francis- Site Number : 8400034, Milwaukee, Wisconsin
Medical College of Wisconsin - Milwaukee Campus- Site Number : 8400038, Milwaukee, Wisconsin
Investigational Site Number : 0320003, Rosario, Santa Fe
Investigational Site Number : 0320002, Buenos Aires, Not set
Investigational Site Number : 0321010, Buenos Aires, Not set
Investigational Site Number : 0320007, Buenos Aires, Not set
Investigational Site Number : 0320001, Buenos Aires, Not set
Investigational Site Number : 0360005, Saint Leonards, New South Wales
Investigational Site Number : 0360001, Woolloongabba, Queensland
Investigational Site Number : 0360002, Melbourne, Victoria
Investigational Site Number : 0560008, Brussels, Not set
Investigational Site Number : 0560006, Gent, Not set
Investigational Site Number : 0560007, Kortrijk, Not set
Investigational Site Number : 0560003, Melsbroek, Not set
Investigational Site Number : 0560005, Overpelt, Not set
Centro de Pesquisas da Clínica IBIS- Site Number : 0760030, Salvador, Bahia
L2IP - Instituto de Pesquisas Clínicas- Site Number : 0760003, Brasília, Distrito Federal
Universidade Federal de Goias- Site Number : 0760024, Goiânia, Goiás
Freire Pesquisa Clínica - Belo Horizonte - Rua Piauí- Site Number : 0760025, Belo Horizonte, Minas Gerais
Instituto de Neurologia de Curitiba - Ecoville- Site Number : 0760001, Curitiba, Paraná
Hospital Moinhos de Vento- Site Number : 0760005, Porto Alegre, Rio Grande Do Sul
Clínica Neurológica- Site Number : 0760007, Joinville, Santa Catarina
Prognosis Pesquisa Clinica- Site Number : 0760032, Santo Andre, São Paulo
CPQuali Pesquisa Clinica - São Paulo- Site Number : 0760002, São Paulo, Not set
PSEG Centro de Pesquisa Clínica- Site Number : 0760021, São Paulo, Not set
Jordy Sinapse- Site Number : 0760004, São Paulo, Not set
Investigational Site Number : 1000009, Blagoevgrad, Not set
Investigational Site Number : 1000008, Panagyurishte, Not set
Investigational Site Number : 1000007, Pazardzhik, Not set
Investigational Site Number : 1000002, Pleven, Not set
Investigational Site Number : 1000010, Pleven, Not set
Investigational Site Number : 1000004, Sofia, Not set
Investigational Site Number : 1000001, Sofia, Not set
Investigational Site Number : 1000006, Sofia, Not set
Investigational Site Number : 1000005, Sofia, Not set
Investigational Site Number : 1240011, Calgary, Alberta
Investigational Site Number : 1240005, Burnaby, British Columbia
Investigational Site Number : 1240010, Vancouver, British Columbia
Investigational Site Number : 1240015, North York, Ontario
Investigational Site Number : 1240002, Ottawa, Ontario
Investigational Site Number : 1240012, Toronto, Ontario
Investigational Site Number : 1240001, Gatineau, Quebec
Investigational Site Number : 1240008, Lévis, Quebec
Investigational Site Number : 1240009, Montreal, Quebec
Investigational Site Number : 1240016, Pointe-claire, Quebec
Investigational Site Number : 1240003, Quebec City, Quebec
Investigational Site Number : 1240006, Sherbrooke, Quebec
Investigational Site Number : 1520003, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520002, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1520001, Santiago, Reg Metropolitana De Santiago
Investigational Site Number : 1560007, Beijing, Not set
Investigational Site Number : 1560005, Beijing, Not set
Investigational Site Number : 1560008, Beijing, Not set
Investigational Site Number : 1560003, Changchun, Not set
Investigational Site Number : 1560011, Changsha, Not set
Investigational Site Number : 1560004, Chengdu, Not set
Investigational Site Number : 1560045, Fuzhou, Not set
Investigational Site Number : 1560002, Guangzhou, Not set
Investigational Site Number : 1561027, Harbin, Not set
Investigational Site Number : 1560010, Jiazhuang, Not set
Investigational Site Number : 1560001, Shanghai, Not set
Investigational Site Number : 1560006, Taiyuan, Not set
Investigational Site Number : 1560012, Tianjin, Not set
Investigational Site Number : 1560009, Wuhan, Not set
Investigational Site Number : 1560013, Xi An, Not set
Investigational Site Number : 1560034, Zhengzhou, Not set
Investigational Site Number : 2030011, Brno, Not set
Investigational Site Number : 2030005, Brno, Not set
Investigational Site Number : 2030002, Hradec Králové, Not set
Investigational Site Number : 2030006, Jihlava, Not set
Investigational Site Number : 2030007, Ostrava, Not set
Investigational Site Number : 2030003, Prague, Not set
Investigational Site Number : 2030004, Prague, Not set
Investigational Site Number : 2030008, Prague, Not set
Investigational Site Number : 2030009, Teplice, Not set
Investigational Site Number : 2030001, Zlín, Not set
Investigational Site Number : 2500011, Bron, Not set
Investigational Site Number : 2500005, Créteil, Not set
Investigational Site Number : 2500006, La Tronche, Not set
Investigational Site Number : 2500009, Lille, Not set
Investigational Site Number : 2500015, Montpellier, Not set
Investigational Site Number : 2500002, Nice, Not set
Investigational Site Number : 2500007, Paris, Not set
Investigational Site Number : 2500014, Paris, Not set
Investigational Site Number : 2500003, Rennes, Not set
Investigational Site Number : 2500010, Saint-herblain, Not set
Investigational Site Number : 2500001, Strasbourg, Not set
Investigational Site Number : 2760009, Bielefeld, Not set
Investigational Site Number : 2760010, Bochum, Not set
Investigational Site Number : 2760002, Düsseldorf, Not set
Investigational Site Number : 2760007, Jena, Not set
Investigational Site Number : 2760003, Leipzig, Not set
Investigational Site Number : 2760006, Münster, Not set
Investigational Site Number : 2760001, ULM, Not set
Investigational Site Number : 3000003, Athens, Not set
Investigational Site Number : 3000005, Athens, Not set
Investigational Site Number : 3000004, Ioannina, Not set
Investigational Site Number : 3000001, Larissa, Not set
Investigational Site Number : 3000002, Thessaloniki, Not set
Investigational Site Number : 3480003, Budapest, Not set
Investigational Site Number : 3480004, Budapest, Not set
Investigational Site Number : 3480006, Budapest, Not set
Investigational Site Number : 3480002, Gyor, Not set
Investigational Site Number : 3560017, Delhi, Not set
Investigational Site Number : 3560008, Hyderabad, Not set
Investigational Site Number : 3560005, Nashik, Not set
Investigational Site Number : 3560006, Shimla, Not set
Investigational Site Number : 3560004, Thiruvananthapuram, Not set
Investigational Site Number : 3800004, Florence, Firenze
Investigational Site Number : 3800011, Genoa, Genova
Investigational Site Number : 3800008, Pozzilli, Isernia
Investigational Site Number : 3800002, Milan, Milano
Investigational Site Number : 3800016, Milan, Milano
Investigational Site Number : 3800010, Naples, Napoli
Investigational Site Number : 3800006, Cefalù, Palermo
Investigational Site Number : 3800015, Rome, Roma
Investigational Site Number : 3800001, Rome, Roma
Investigational Site Number : 3800013, Rome, Roma
Investigational Site Number : 3800021, Rome, Roma
Investigational Site Number : 3800009, Bologna, Not set
Investigational Site Number : 3800014, Chieti, Not set
Investigational Site Number : 3800025, Ferrara, Not set
Investigational Site Number : 3800019, Foggia, Not set
Investigational Site Number : 3800026, Novara, Not set
Investigational Site Number : 3800017, Palermo, Not set
Investigational Site Number : 3800029, Parma, Not set
Investigational Site Number : 3800005, Pavia, Not set
Investigational Site Number : 3800030, Ravenna, Not set
Investigational Site Number : 3920003, Koriyama, Fukushima
Investigational Site Number : 3920014, Asahikawa, Hokkaido
Investigational Site Number : 3920007, Himeji, Hyogo
Investigational Site Number : 3920010, Sagamihara, Kanagawa
Investigational Site Number : 3920015, Higashimatsuyama, Saitama
Investigational Site Number : 3920016, Kodaira, Tokyo
Investigational Site Number : 3920002, Chiba, Not set
Investigational Site Number : 3920013, Fukuoka, Not set
Investigational Site Number : 3920001, Kyoto, Not set
Investigational Site Number : 3920011, Tokyo, Not set
Investigational Site Number : 3920012, Tokyo, Not set
Investigational Site Number : 4100001, Goyang-si, Gyeonggi-do
Investigational Site Number : 4100007, Seongnam-si, Gyeonggi-do
Investigational Site Number : 4100002, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100004, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 4100003, Seoul, Seoul-teukbyeolsi
Investigational Site Number : 5280002, Rotterdam, Not set
Investigational Site Number : 5280001, Sittard-geleen, Not set
Investigational Site Number : 6160005, Krakow, Malopolskie
Investigational Site Number : 6160006, Rzeszow, Podkarpackie
Investigational Site Number : 6160007, Bialystok, Podlaskie
Investigational Site Number : 6160010, Katowice, Slaskie
Investigational Site Number : 6160011, Katowice, Slaskie
Investigational Site Number : 6160002, Plewiska, Wielkopolskie
Investigational Site Number : 6160012, Poznan, Wielkopolskie
Investigational Site Number : 6200001, Braga, Not set
Investigational Site Number : 6200011, Lisbon, Not set
Investigational Site Number : 6200007, Lisbon, Not set
Investigational Site Number : 6200006, Lisbon, Not set
Investigational Site Number : 6200002, Matosinhos, Not set
San Juan MS Center- Site Number : 8400106, Guaynabo, Not set
Investigational Site Number : 7240018, Murcia, Almería
Investigational Site Number : 7240016, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240010, Barcelona, Barcelona [Barcelona]
Investigational Site Number : 7240011, L'hospitalet de Llobregat, Catalunya [Cataluña]
Investigational Site Number : 7240012, Donostia-san Sebastian, Gipuzkoa
Investigational Site Number : 7240024, Girona, Girona [Gerona]
Investigational Site Number : 7240013, Las Palmas de Gran Canaria, Las Palmas
Investigational Site Number : 7240015, Lleida, Lleida [Lérida]
Investigational Site Number : 7240017, Majadahonda, Madrid
Investigational Site Number : 7240001, Pozuelo de Alarcón, Madrid
Investigational Site Number : 7240009, Barakaldo, Pais Vasco
Investigational Site Number : 7240014, Pontevedra, Pontevedra [Pontevedra]
Investigational Site Number : 7240007, Seville, Sevilla
Investigational Site Number : 7240004, Córdoba, Not set
Investigational Site Number : 7240006, Madrid, Not set
Investigational Site Number : 7240023, Madrid, Not set
Investigational Site Number : 7240002, Madrid, Not set
Investigational Site Number : 7240003, Madrid, Not set
Investigational Site Number : 7240022, Madrid, Not set
Investigational Site Number : 7240005, Málaga, Not set
Investigational Site Number : 7240008, Valencia, Not set
Investigational Site Number : 7520001, Gothenburg, Not set
Investigational Site Number : 7520005, Huddinge, Not set
Investigational Site Number : 7520003, Malmö, Not set
Investigational Site Number : 7520002, Stockholm, Not set
Investigational Site Number : 7920018, Ankara, Not set
Investigational Site Number : 7920011, Ankara, Not set
Investigational Site Number : 7920020, Bursa, Not set
Investigational Site Number : 7920013, Bursa, Not set
Investigational Site Number : 7920005, Eskişehir, Not set
Investigational Site Number : 7920012, Istanbul, Not set
Investigational Site Number : 7920002, Istanbul, Not set
Investigational Site Number : 7920016, Istanbul, Not set
Investigational Site Number : 7920009, Istanbul, Not set
Investigational Site Number : 7920007, Istanbul, Not set
Investigational Site Number : 7920019, Izmir, Not set
Investigational Site Number : 7920008, Izmir, Not set
Investigational Site Number : 7920001, Izmit, Not set
Investigational Site Number : 7920014, Kayseri, Not set
Investigational Site Number : 7920015, Konya, Not set
Investigational Site Number : 7920006, Mersin, Not set
Investigational Site Number : 7920004, Samsun, Not set
Investigational Site Number : 7920003, Sultangazi, Not set
Investigational Site Number : 7920017, VAN, Not set
Investigational Site Number : 8040001, Chernivtsi, Not set
Investigational Site Number : 8040009, Ivano-frankivsk, Not set
Investigational Site Number : 8040003, Krykhivtsi, Not set
Investigational Site Number : 8040006, Kyiv, Not set
Investigational Site Number : 8040008, Lutsk, Not set
Investigational Site Number : 8040004, Lviv, Not set
Investigational Site Number : 8040002, Lviv, Not set
Investigational Site Number : 8040005, Vinnytsia, Not set
Investigational Site Number : 8260011, Gwent, Blaenau Gwent
Investigational Site Number : 8260007, Cardiff, Cardiff [Caerdydd Gb-crd]
Investigational Site Number : 8260001, Exeter, Devon
Investigational Site Number : 8260013, London, England
Investigational Site Number : 8260006, Newcastle Upon Tyne, England
Investigational Site Number : 8260003, Canterbury, Kent
Investigational Site Number : 8260008, Salford, Manchester
Investigational Site Number : 8260004, Oxford, Oxfordshire
Investigational Site Number : 8260005, Swansea, Swansea [Abertawe Gb-ata]
Investigational Site Number : 8260010, Inverness, Not set
Investigational Site Number : 8260009, Liverpool, Not set
Conditions: Multiple Sclerosis
A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Recruiting
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Southern Cancer Center, PC, Daphne, Alabama +190 locations
Southern Cancer Center, PC, Daphne, Alabama
Local Institution - 0283, Hot Springs, Arkansas
Florida Cancer Specialists - South, Fort Myers, Florida
Mid Florida Hematology and Oncology Center, Orange City, Florida
Florida Cancer Specialists - North, Saint Petersburg, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Marietta, Georgia
Illinois Cancer Care, Peoria, Illinois
Local Institution - 0037, Minneapolis, Minnesota
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Duke Cancer Institute, Durham, North Carolina
Oncology Hematology Care, Cincinnati, Ohio
Local Institution - 0239, Cleveland, Ohio
Sanford Cancer Center, Sioux Falls, South Dakota
Local Institution - 0307, Knoxville, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Texas Oncology - Central/South Texas, Austin, Texas
Texas Oncology - Northeast Texas, Tyler, Texas
Oncology & Hematology Associates of Southwest Virginia, Inc., Roanoke, Virginia
Swedish Cancer Institute - Edmonds, Edmonds, Washington
Swedish Medical Center, Seattle, Washington
Local Institution - 0007, Tacoma, Washington
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0100, Buenos Aires, Ciudad Autónoma De Buenos Aires
Clinica Adventista Belgrano, Caba, Ciudad Autónoma De Buenos Aires
Instituto Médico Río Cuarto, Río Cuarto, Córdoba
GenesisCare - Campbelltown, Campbelltown, New South Wales
Nepean Hospital, Penrith, New South Wales
Gallipoli Medical Research Ltd, Brisbane, Queensland
Grampians Health, Ballarat Central, Victoria
St. John of God Murdoch Hospital, Murdoch, Western Australia
Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Kepler Universitätsklinikum, Linz, Not set
Landeskrankenhaus Rankweil, Rankweil, Not set
Local Institution - 0250, Wien, Not set
Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De
UZ Gent, Gent, Oost-Vlaanderen
VITAZ, Sint-Niklaas, Oost-Vlaanderen
Local Institution - 0180, Leuven, Vlaams-Brabant
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set
Local Institution - 0166, Fortaleza, Ceará
Local Institution - 0165, Porto Alegre, Rio Grande Do Sul
Local Institution - 0169, Porto Alegre, Rio Grande Do Sul
Local Institution - 0170, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0163, Itajaí, Santa Catarina
Local Institution - 0178, Barretos, São Paulo
Local Institution - 0111, Sao Paulo, São Paulo
Local Institution - 0289, Edmonton, Alberta
CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec
Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski, Rimouski, Quebec
IUCPQ, Quebec, Not set
Orlandi Oncologia, Santiago, Región Metropolitana De Santiago
Fundacion Arturo Lopez Perez (FALP), Santiago, Región Metropolitana De Santiago
Pontificia Universidad Catolica de Chile, Santiago, Región Metropolitana De Santiago
Bradfordhill, Santiago, Región Metropolitana De Santiago
Oncocentro Apys, Viña del Mar, Valparaíso
Beijing Cancer hospital, Beijing, Beijing
Beijing Chest Hospital,Capital Medical University, Beijing, Beijing
Chongqing University Cancer Hospital, Chongqing, Chongqing
Fujian Cancer Hospital, Fuzhou, Fujian
Local Institution - 0212, Xiamen, Fujian
Cancer Hospital of Shantou University Medical College, Shantou, Guangdong
Local Institution - 0227, Harbin, Heilongjiang
Local Institution - 0208, Wuhan, Hubei
Hubei Cancer Hospital, Wuhan, Hubei
Local Institution - 0216, Changsha, Hunan
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
Jilin Province Tumor Hospital, Changchun, Jilin
Local Institution - 0235, Shenyang, Liaoning
Xi'an International Medical Center Hospital, Xi'an, Shaanxi
Shandong Cancer Hospital, Jinan, Shandong
Local Institution - 0206, Shanghai, Shanghai
Zhongshan Hospital,Fudan University, Shanghai, Shanghai
Sichuan Cancer hospital, Chengdu, Sichuan
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang
Shanghai East Hospital, Shanghai, Not set
Masarykuv onkologicky ustav, Brno, Brno-město
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Ostrava Město
Fakultni Thomayerova nemocnice, Prague, Praha 4
Fakultni nemocnice Olomouc, Olomouc, Not set
Hôpital Arnaud de Villeneuve - CHU Montpellier, Montpellier, Hérault
Chu Grenoble Alpes, La Tronche, Isère
CHU Lille - Institut Coeur Poumon, Lille Cedex, Nord
L Hopital Nord Ouest, Gleize, Rhône
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Centre Hospitalier Intercommunal de Créteil, Créteil, Val-de-Marne
Gustave Roussy, Villejuif, Val-de-Marne
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Institut Curie, Paris, Not set
Centre Hospitalier de Cornouaille Quimper - Concarneau, Quimper, Not set
Krankenhaus Nordwest GmbH, Frankfurt, Hessen
Pius Hospital Oldenburg, Oldenburg, Niedersachsen
Klinikum Köln-Merheim, Köln, Nordrhein-Westfalen
Krankenhaus Martha-Maria Halle-Dölau, Halle, Sachsen-Anhalt
Zentralklinik Bad Berka, Bad Berka, Thüringen
Local Institution - 0263, Berlin, Not set
Asklepios Klinik Gauting GmbH, Gauting, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Robert Bosch Krankenhaus GmbH, Stuttgart, Not set
Errikos Dunant Hospital Center, Athens, Attikí
Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí
"Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Kentrikí Makedonía
European Interbalkan Medical Center, Thessaloniki, Thessaloníki
University General Hospital of Larissa, Larissa, Thessalía
Local Institution - 0278, New Delhi, Delhi
Local Institution - 0274, Bengaluru, Karnataka
Local Institution - 0271, Madurai, Tamil Nadu
Local Institution - 0277, Varanasi, Uttar Pradesh
Local Institution - 0273, Kolkata, West Bengal
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia
Istituto Nazionale Tumori Regina Elena, Rome, Roma
AO Santa Maria della Misericordia, Perugia, Umbria
Casa di Cura Dott. Pederzoli, Peschiera del Garda, Verona
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Istituto Europeo di Oncologia IRCCS, Milano, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime
Kurume University Hospital, Kurume, Fukuoka
Hokkaido University Hospital, Sapporo, Hokkaido
Kobe City Medical Center General Hospital, Kobe-shi, Hyogo
Kanazawa University Hospital, Kanazawa, Ishikawa
Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa
Sendai Kousei Hospital, Sendai, Miyagi
Nara Medical University Hospital, Kashihara city, Nara
Kurashiki Central Hospital, Kurashiki, Okayama
Kansai Medical University Hospital, Hirakata, Osaka
Kindai University Hospital- Osakasayama Campus, Osaka Sayama, Osaka
Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka
Saitama Medical University International Medical Center, Hidaka, Saitama
Saitama Prefectural Cancer Center, Ina-machi, Saitama
Hamamatsu University Hospital, Hamamatsu, Shizuoka
Nippon Medical School Hospital, Bunkyo-ku, Tokyo
The Cancer Institute Hospital of JFCR, Koto, Tokyo
Fukushima Medical University, Fukushima, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do
Ajou University Hospital, Suwon-si, Kyǒnggi-do
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]
Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
Keimyung University Dongsan Hospital, Daegu, Taegu-Kwangyǒkshi
Local Institution - 0311, Kuching, Sarawak
Local Institution - 0310, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0312, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0148, Pachuca, Hidalgo
Local Institution - 0146, Guadalajara, Jalisco
Local Institution - 0147, Monterrey, Nuevo León
Local Institution - 0145, Puebla, Not set
Amsterdam UMC, locatie VUmc, Amsterdam, Noord-Holland
Ziekenhuis Rijnstate, Arnhem, Not set
University Medical Center Groningen, Groningen, Not set
Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Pomorskie
Przychodnia Lekarska KOMED, Konin, Wielkopolskie
Pratia Poznań, Poznań, Wielkopolskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set
Instytut Centrum Zdrowia Matki Polki, Łódź, Łódzkie
SC Memorial Healthcare International SRL, Bucharest, București
Institutul Oncologic Bucuresti, Bucharest, București
SC Radiotherapy Center Cluj SRL, Florești, Cluj
Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj
Institutul Oncologic Cluj, Cluj, Not set
S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set
Institutul Regional de Oncologie, Iași, Not set
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña]
Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña]
Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya [Cataluña]
Hospital Universitario de Jaen, Jaen, Jaén
Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Hospital General Universitario de Valencia, Valencia, Valenciana, Comunitat
Local Institution - 0299, Sevilla, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Kantonsspital Graubünden, Chur, Not set
Kantonsspital Winterthur, Winterthur, Not set
UniversitätsSpital Zürich, Zürich, Not set
Local Institution - 0158, Cigli, İzmir
Local Institution - 0154, Adana, Not set
Local Institution - 0157, Ankara, Not set
Local Institution - 0177, Ankara, Not set
Local Institution - 0153, Istanbul, Not set
Local Institution - 0197, London, London, City Of
James Cook University Hospital, Central Middlesbrough, Middlesbrough
Aberdeen Royal Infirmary, Aberdeen, Not set
Local Institution - 0108, Leicester, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Clatterbridge Cancer Centre, Wirral, Not set
Conditions: Extensive-Stage Small Cell Lung Cancer
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
Recruiting
The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks and may include up to 44 visits. Additional treatment may be available to participants via a Continued Access Period.
The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks and may include up to 44 visits. Additional treatment may be available to participants via a Continued Access Period. Read Less
Gender:
ALL
Ages:
Between 2 years and 19 years
Trial Updated:
08/21/2025
Locations: UCSF Medical Center at Mission Bay, San Francisco, California +59 locations
UCSF Medical Center at Mission Bay, San Francisco, California
Connecticut Children's Medical Center, Hartford, Connecticut
Emory University School of Medicine, Atlanta, Georgia
Children's Center for Digestive Health Care, LLC, Atlanta, Georgia
Boston Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital, Waltham, Massachusetts
Icahn School of Medicine at Mount Sinai, New York, New York
Cook Children's Medical Center, Fort Worth, Texas
Pediatric Specialists of Virginia, Fairfax, Virginia
Medizinische Universität Wien, Vienna, Not set
UZ Brussel, Brussels, Not set
Cliniques universitaires Saint-Luc, Brussels, Not set
Antwerp University Hospital, Edegem, Not set
UZ Gent, Gent, Not set
UZ Leuven, Leuven, Not set
Centro de Pesquisa Sao Lucas, Campinas, Not set
Hospital Pequeno Príncipe / Associação Hospitalar de Proteção à Infância, Curitiba, Not set
Universidade Federal de Goias, Goiania, Not set
Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Not set
Hospital Universitario Cassiano Antonio de Moraes, Vitoria, Not set
Integral Pesquisa e Ensino, Votuporanga, Not set
The Hospital for Sick Children, Toronto, Not set
CHU d'Amiens-Picardie - Hôpital Sud, Amiens, Not set
Hôpital Jeanne de Flandre, Lille, Not set
Hôpital Armand Trousseau, Paris, Not set
Hôpital Universitaire Necker Enfants Malades, Paris, Not set
Universitätsmedizin Johannes Gutenberg Universität Mainz, Mainz, Not set
Dr. von Haunersches Kinderspital, Munich, Not set
Rambam Health Care Campus, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Hadassah Medical Center, Jerusalem, Not set
Schneider Children's Medical Center, Petah-Tikva, Not set
Yitzhak Shamir Medical Center, Zerifin, Not set
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Not set
Ospedale Maggiore Azienda USL di Bologna, Bologna, Not set
Azienda Ospedaliera Universitaria Meyer IRCCS, Firenze, Not set
Ospedale dei Bambini Vittore Buzzi, Milan, Not set
AOU Policlinico Umberto I, Roma, Not set
Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
Institute of Science Tokyo Hospital, Bunkyō, Not set
Tsujinaka Hospital - Kashiwanoha, Kashiwa, Not set
Kyungpook National University Chilgok Hospital, Deagu, Not set
Seoul National University Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Amsterdam UMC, locatie AMC, Amsterdam, Not set
Erasmus Medisch Centrum, Rotterdam, Not set
Korczowski Bartosz, Gabinet Lekarski, Rzeszów, Not set
Twoja Przychodnia SCM, Szczecin, Not set
Centrum Zdrowia Dziecka w Warszawie, Warsaw, Not set
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś, Warszawa, Not set
Centrum Medyczne Oporów, Wroclaw, Not set
Centro Hospitalar de Sao Joao - Hospital de Sao Joao, Porto, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Sant Joan de Déu, Esplugues de Llobregat, Not set
Hospital Universitari Parc Tauli, Sabadell, Not set
Hospital Universitari i Politecnic La Fe, València, Not set
Royal London Hospital, London, Not set
The John Radcliffe Hospital, Oxford, Not set
Sheffield Children's Hospital, Sheffield, Not set
Conditions: Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
Recruiting
This study will be conducted to compare the efficacy of axatilimab versus placebo in combination with corticosteroids as initial treatment for moderate or severe chronic graft-versus-host disease (cGVHD).
This study will be conducted to compare the efficacy of axatilimab versus placebo in combination with corticosteroids as initial treatment for moderate or severe chronic graft-versus-host disease (cGVHD). Read Less
Gender:
ALL
Ages:
12 years and above
Trial Updated:
08/21/2025
Locations: University of California San Diego Medical Center, Moores Cancer Center, La Jolla, California +87 locations
University of California San Diego Medical Center, Moores Cancer Center, La Jolla, California
Colorado Blood Cancer Institute, Denver, Colorado
Childrens National Hospital, Washington, District of Columbia
Orlando Health Cancer Institute Downtown Orlando, Orlando, Florida
Memorial Cancer Institute, Pembroke Pines, Florida
University of Illinois, Chicago, Illinois
Massachusetts General Hospital, Boston, Massachusetts
Henry Ford Hospital, Detroit, Michigan
Corewell Health Hematology Oncology, Grand Rapids, Michigan
Hackensack University Medical Center, Hackensack, New Jersey
Rutgers Cancer Institute of Nj, New Brunswick, New Jersey
Stony Brook University Medical Center, Stony Brook, New York
Jefferson University Hospitals, Philadelphia, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Upstate, Greenville, South Carolina
Texas Transplant Institute, San Antonio, Texas
Intermountain Blood and Marrow Transplant, Salt Lake City, Utah
West Virginia University Cancer Institute, Morgantown, West Virginia
Royal Prince Alfred Hospital, Sydney, New South Wales
Royal Adelaide Hospital, Adelaide, South Australia
Austin Health Medical Oncology and Clinical Haematology, Heidelberg, Victoria
Innsbruck University Hospital, Innsbruck, Not set
Ordensklinikum Linz Gmbh Elisabethinen, Linz Cet, Not set
St. Anna Childrens Hospital, Vienna, Not set
Alberta'S Children Hospital, Calgary, Alberta
Juravinski Cancer Centre, Hamilton, Ontario
Princess Margaret Cancer Center, Toronto, Ontario
Vancouver General Hospital, Vancouver, Not set
Rigshospitalet, Copenhagen, Not set
Chu Amiens Picardie - Hopital Sud, Amiens Cedex 1, Not set
Hopitaux de Brabois, Nancy, Not set
Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu, Nantes, Not set
Chu de Nice - Hospital L Archet, Nice Cedex 3, Not set
Hospital Saint Louis, Paris, Not set
Hospices Civils de Lyon Centre Hospitalier Lyon Sud, Pierre Benite, Not set
Universitaire Du Cancer de Toulouse Institut Claudius Regaud Iuct-Oncopole, Toulouse, Not set
University Medical Center Rwth Aachen, Aachen, Not set
Charite Universitatsmedizin Berlin, Berlin, Not set
Universitaetsklinikum Bonn, University Hospital Bonn, Bonn, Not set
University Clinic Carl Gustav Carus Technical University Dresden, Dresden, Not set
Universitaetsklinikum Erlangen, Erlangen, Not set
Universitatsklinikum Halle (Saale), Halle, Not set
University Hospital Schleswig-Holstein Campus Kiel, Kiel, Not set
Universitatsklinikum Leipzig, Leipzig, Not set
Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii, Mainz, Not set
Klinikum Der Philipps-Universitaet Marburg, Marburg, Not set
St. James Hospital, Dublin 8, Not set
Azienda Ospedaliero-Universitaria Di Alessandria Ss.Antonio E Biagio E Cesare Arrigo, Alessandria, Not set
Azienda Ospedaliero Universitaria Delle Marche, Ancona, Not set
Asst Degli Spedali Civili Di Brescia, Brescia, Not set
Irccs Azienda Ospedaliera Universitaria San Martino, Genova, Not set
Ospedale San Raffaele - Milano, Milano, Not set
Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli, Napoli, Not set
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo, Not set
Irccs Fondazione Policlinico San Matteo, Pavia, Not set
Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Not set
Azienda Policlinico Umberto 1 Universita Sapienza Di Roma, Rome, Not set
Ospedale Pediatrico Bambino Gesu Irccs, Rome, Not set
I.R.C.C.S. Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Not set
Azienda Ospedaliera Card. G. Panico, Tricase, Not set
Centro Ricerche Cliniche Di Verona, Verona, Not set
Anjo Kosei Hospital, Aichi-ken, Not set
Fujita Health University Hospital, Aichi, Not set
Kyushu University Hospital, Fukuoka, Not set
Hiroshima University Hospital, Hiroshima-shi, Not set
Kobe City Medical Center General Hospital, Hyogo, Not set
Tokai University Hospital, Isehara Kanagawa, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto Kumamoto, Not set
Gunma Saiseikai Maebashi Hospital, Maebashi, Not set
Tohoku University Hospital, Miyagi, Not set
Okayama University Hospital, Okayama-ken, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Hokkaido University Hospital, Sapporo Hokkaido, Not set
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Not set
Hospital General Universitario Vall D Hebron, Barcelona, Not set
Hospital de La Santa Creu I Sant Pau, Barcelona, Not set
Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Hospital Puerta de Hierro, Majadahonda, Not set
Hospital Universitario Donostia, San Sebastian, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Universitari I Politecnic La Fe, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Bristol Haematology and Oncology Centre, Bristol, Not set
Royal Marsden Hospital, London, Not set
University College London Hospitals (Uclh), London, Not set
Nottingham University Hospitals, Nottingham, Not set
Plymouth Hospitals Nhs Trust, Plymouth, Not set
Conditions: Chronic Graft-versus-host-disease
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
Recruiting
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. Th... Read More
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart disease.
This study has 2 parts. In the first part, participants get empagliflozin or placebo matching BI 690517 for at least 6 weeks. Participants continue taking ACEi or ARB throughout the study if such treatments are indicated. In the second part, participants are divided into 2 groups by chance. One group takes BI 690517 tablets and the other group takes placebo tablets. Placebo tablets look like BI 690517 tablets but do not contain any medicine. Participants take 1 tablet once a day in addition to empagliflozin for the duration of the study.
The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 4 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants' health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Apogee Clinical Research, Huntsville, Alabama +188 locations
Apogee Clinical Research, Huntsville, Alabama
Southwest Kidney Institute, Surprise, Arizona
Florida Kidney Physicians LLC, Jacksonville Beach, Florida
Total Research Group, LLC, Miami, Florida
East Coast Institute For Research LLC, Macon, Georgia
Kootenai Research Services, Coeur d'Alene, Idaho
Kansas Nephrology Research Institute, LLC, Wichita, Kansas
Lake Michigan Nephrology, Saint Joseph, Michigan
St. Clair Nephrology Research, LLC, Shelby, Michigan
Great Plains Nephrology, North Platte, Nebraska
Seacoast Kidney and Hypertension Specialists, Portsmouth, New Hampshire
Metrolina Nephrology Associates, PA, Charlotte, North Carolina
Brookview Hills Research Associates LLC, Winston-Salem, North Carolina
Northeast Endocrine Metabolic Associates, Philadelphia, Pennsylvania
Clinical Renal Associates, Upland, Pennsylvania
Nephrology Associates, Inc, East Providence, Rhode Island
Dallas Nephrology Associates Medical Clinic, DeSoto, Texas
Texas Institute for Kidney and Endocrine Disorders, Lufkin, Texas
Renal Specialists of Houston, PA, Pasadena, Texas
University of Virginia Health System, Charlottesville, Virginia
Tidewater Physicians Multispecialty Group, Newport News, Virginia
Providence Medical Research Center, Spokane, Washington
Fundação Oswaldo Ramos (Hospital do Rim), São Paulo, Not set
University of Alberta Hospital (University of Alberta), Edmonton, Alberta
Royal Inland Hospital, Kamloops, British Columbia
Kelowna General Hospital, Kelowna, British Columbia
Northern Health, Prince George, British Columbia
Fraser Health, Surrey, British Columbia
St. Paul's Hospital (Vancouver), Vancouver, British Columbia
CIUSSS Nord de l'île de Montreal, Quebec, Montréal
Queen's University, Kingston, Ontario
London Regional Cancer Program - London Health Sciences Ctr., London, Ontario
Lakeridge Health Oshawa, Oshawa, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
St. Michael's Hospital, Toronto, Ontario
Toronto General Hospital, Toronto, Ontario
Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Not set
CHU de Quebec-Universite Laval Research Centre, Quebec, Not set
Herlev and Gentofte Hospital, Herlev, Not set
Kolding Hospital, Kolding, Not set
Rigshospitalet, København, København, Not set
Odense University Hospital, Odense, Not set
Zealand University Hospita; Roskilde, Roskilde, Not set
Universitätsklinikum Aachen, AöR, Aachen, Not set
Nephrologische Gemeinschaftspraxis Bad Nenndorf, Bad Nenndorf, Not set
Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Bad Oeynhausen, Not set
Praxis für Nierenkrankheiten und Dialyse Helle Mitte, Berlin, Not set
Universitätsklinikum Bonn AöR, Bonn, Not set
Städtisches Klinikum Braunschweig gGmbH, Braunschweig, Not set
Klinikum Dortmund gGmbH, Dortmund, Not set
Universitätsklinikum Düsseldorf, Düsseldorf, Not set
Dialysezentrum Elsenfeld, Elsenfeld, Not set
Agaplesion Markus Krankenhaus, Frankfurt am Main, Not set
Universitätsklinikum Frankfurt, Frankfurt am Main, Not set
ClinPhenomics CVC GmbH, Frankfurt, Not set
Nierenzentrum Freiburg, Freiburg, Not set
Universitätsklinikum Gießen und Marburg GmbH, Gießen, Not set
Universitätsklinikum Hamburg, Eppendorf, Hamburg, Not set
Medizinische Hochschule Hannover, Hannover, Not set
Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen, Hannover, Not set
BAG für Nephrologie und Dialyse, Heilbronn, Not set
Ruhr-Universität Bochum, Herne, Not set
Universität des Saarlandes, Homburg, Not set
Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Not set
Klinikum Konstanz, Konstanz, Not set
Dr. Vehling-Kaiser MVZ GmbH, Landshut, Not set
KfH Nierenzentrum Leipzig, Leipzig, Not set
Universitätsklinikum Magdeburg AöR, Magdeburg, Not set
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Not set
Klinikum der Universität München - Campus Innenstadt, München, Not set
Dialysezentrum Neckarsulm, Neckarsulm, Not set
Dialysezentrum Rotenburg, Rotenburg, Not set
MVZ Dialysezentrum Schweinfurt, Schweinfurt, Not set
Robert-Bosch-Krankenhaus GmbH, Stuttgart, Not set
KfH-Nierenzentrum Traunstein, Traunstein, Not set
Nephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen, Not set
Nierenzentrum Wiesbaden, Wiesbaden, Not set
Helios Universitätsklinikum Wuppertal, Wuppertal, Not set
Universitätsklinikum Würzburg AÖR, Würzburg, Not set
Manipal Hospital, Bangalore, Not set
St John's Medical College, Bangalore, Not set
Institute of Post Graduate Medical Education and Research, Chandigarh, Not set
Karnataka Medical college and research institute, Hubballi, Not set
Osmania Medical College & Hospital, Hyderabad, Not set
Nil Ratan Sircar Medical College & Hospital, Kolkata, Not set
IQRAA International hospital & research centre., Kozhikode, Not set
Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Not set
Muljibhai Patel Urological Hospital, Nadiad, Not set
Max Super Specialty Hospital, Saket, New Delhi, Not set
Epitome Kidney Urology Institute and Lions Hospital, New Delhi, Not set
All India Institute of Medical Sciences, New Delhi, Not set
Indira Gandhi Institute of Medical Sciences, Patna, Not set
Jawaharlal Institute of Postgraduate Medical Education, Pondicherry, Not set
All India Institute of Medical Sciences, Raipur, Not set
Yashoda Hospitals - Secunderabad, Secunderabad, Not set
Kimshealth, Trivandrum, Not set
Christian Medical College, Vellore, Not set
Ospedale Civile Ss. Antonio e Biagio, Alessandria, Not set
Asti-Ospedale Cardinal Massaia, Asti, Not set
Azienda Universitaria Ospedaliera Consorziale Policlinico Bari, Bari, Not set
ASST Papa Giovanni XXIII, Bergamo, Not set
Policlinico S. Orsola-Malpighi, Bologna, Not set
Azienda Ospedaliera ARNAS G. Brotzu, Cagliari, Not set
Chieri-Ospedale Maggiore, Chieri, Not set
A.S.O.S. Croce e Carle, Cuneo, Not set
Firenze-Ospedale San Giovanni di Dio, Firenze, Not set
Azienda Ospedaliera Careggi, Firenze, Not set
Azienda Ospedaliera San Martino, Genova, Not set
Asst Santi Paolo E Carlo, Milano, Not set
Fondazione IRCCS San Gerardo dei Tintori, Monza, Not set
Ospedale Maggiore della Carità, Novara, Not set
Azienda Ospedaliera Unversitaria di Parma, Parma, Not set
Fondazione Salvatore Maugeri, Pavia, Not set
Azienda Ospedaliera Universitaria Pisana, Pisa, Not set
Prato-Ospedale Santo Stefano, Prato, Not set
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza, Roma, Not set
IRCCS Ospedale "Casa Sollievo della Sofferenza", San Giovanni Rotondo (Foggia), Not set
Azienda Sociosanitaria Ligure 2, Savona, Not set
Todi-Nuovo Ospedale Media Valle del Tevere, Todi, Not set
Torino-Ospedale Oftalmico, Turin, Not set
Ospedale Castelli - Verbania, Verbania, Not set
Ospedale San Bortolo, Vicenza, Not set
Hospital Ampang, Ampang Jaya, Not set
Hospital Selayang, Batu Caves, Not set
Hospital Sultanah Nora Ismail, Batu Pahat, Not set
Hospital Pulau Pinang-Pulau Pinang-21953, Georgetown, Not set
Hospital Raja Permaisuri Bainun, Ipoh, Not set
Hospital Sultanah Aminah, Johor Bahru, Not set
Hospital Kajang, Kajang, Selangor, Not set
Hospital Tengku Ampuan Rahimah, Klang, Not set
Hospital Queen Elizabeth, Kota Kinabalu, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
University of Malaya Medical Centre, Kuala Lumpur, Not set
Hospital Tuanku Ampuan Najihah, Kuala Pilah, Not set
Hospital Tengku Ampuan Afzan, Kuantan, Not set
Hospital Umum Sarawak, Kuching, Not set
Hospital Kulim, Kulim, Not set
Hospital Melaka, Melaka, Not set
Hospital Pakar Sultanah Fatimah, Muar, Not set
Hospital Seberang Jaya, Perai, Not set
Hospital Sultan Abdul Aziz Shah, Serdang, Not set
Hospital Tuanku Ja'afar, Seremban, Not set
Hospital Taiping, Taiping, Not set
Hospital Teluk Intan, Teluk Intan, Not set
Hospital Sultan Haji Ahmad Shah, Temerloh, Not set
ULS da Região de Aveiro, Aveiro, Not set
Unidade Local de Saúde do Algarve, E.P.E, Faro, Not set
SESARAM, Funchal, Not set
ULS de São João, Porto, Not set
Unidade Local de Saúde de Matosinhos, Senhora da Hora, Not set
Unidade Local De Saude Da Arrabida E.P.E., Setúbal, Not set
E-Da Hospital, Kaohsiung City, Not set
Lotung Poh-Ai Hospital, Luodong Township, Not set
Taipei Medical University-Shuang Ho Hospital, New Taipei City, Not set
Fu Jen Catholic University Hospital, New Taipei City, Not set
Tungs' Taichung MetroHarbor Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan City, Not set
Cathay General Hospital, Taipei, Not set
Taipei Medical University Hospital, Taipei, Not set
Taipei Municipal Wanfang Hospital, Taipei, Not set
South Eastern Health & Social Care Trust, Belfast, Not set
Belfast Health and Social Care Trust, Belfast, Not set
Oakenhurst Medical Practice, Blackburn, Not set
University Hospitals Sussex NHS Foundation Trusts, Brighton, Not set
Southmead Hospital, Bristol, Not set
West Suffolk NHS Foundation Trust, Bury St Edmunds, Not set
Broomfield Hospital, Chelmsford, Not set
Hathaway Medical Centre, Chippenham, Not set
Clevedon Medical Centre, Clevedon, Not set
Queen Alexandra Hospital, Cosham, Not set
Daisy Hill Hospital, County Down, Not set
Dorset County Hospital NHS Foundation Trust, Dorset, Not set
Highland Clinical Research Facility, Fulwood, Not set
Gloucestershire Royal Hospital, Gloucester, Not set
Hereford County Hospital, Hereford, Not set
Aintree University Hospital, Liverpool, Not set
Altnagelvin Area Hospital, Londonderry, Not set
St George's University Hospitals NHS Foundation Trust, London, Not set
Imperial College Healthcare NHS Trust, London, Not set
Norfolk and Norwich University Hospital, Norfolk, Not set
Nottingham University Hospitals NHS Trust, Nottingham, Not set
Churchill Hospital, Oxford, Not set
Pickering Medical Practice, Pickering, Not set
Royal Berkshire Hospital, Reading, Not set
Alexandra Hospital, Redditch, Not set
Alexandra Hospital, Redditch, Not set
The Royal Shrewsbury Hospital, Shrewsbury, Not set
Great Western Hospital, Swindon, Not set
Royal Cornwall Hospital, Truro, Not set
Conditions: Kidney Disease, Chronic
A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab
Recruiting
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).This study will evaluate how safe and effective risankizumab is compared to vedolizumab in treating adult participants with moderate to severe UC who are naive to targeted therapies (TaTs).
Risankizumab and vedolizumab are approved medications for moderate to severe UC in multiple countries. Participants who meet the eligibility criteria... Read More
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).This study will evaluate how safe and effective risankizumab is compared to vedolizumab in treating adult participants with moderate to severe UC who are naive to targeted therapies (TaTs).
Risankizumab and vedolizumab are approved medications for moderate to severe UC in multiple countries. Participants who meet the eligibility criteria will be randomized in a 1:1 ratio to receive open label risankizumab or vedolizumab. Approximately 530 adult participants with moderate to severe UC who are naïve to targeted therapies (TaTs) will be enrolled at 285 sites worldwide.
For participants randomized to risankizumab, drug will be administered intravenous(IV) during the induction period followed by subcutaneous injection during the maintenance period. Participants randomized to vedolizumab will receive drug IV throughout the study.
The duration of the study is approximately 69 weeks for participants randomized to risankizumab and 71 weeks for participants randomized to vedolizumab. This includes up to a 35-day screening period followed by a treatment period of 44 weeks for risankizumab and 46 weeks for vedolizumab.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular outpatient visits during the study. The effect and safety of the treatment will be checked by medical assessments, evaluation of side effects and completing questionnaires. Read Less
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/21/2025
Locations: Digestive Health Specialists /ID# 274785, Dothan, Alabama +93 locations
Digestive Health Specialists /ID# 274785, Dothan, Alabama
East View Medical Research /ID# 276222, Mobile, Alabama
Arizona Health Research /ID# 274366, Chandler, Arizona
Gastro Care Institute /ID# 274873, Lancaster, California
Hoag Memorial Hospital Presbyterian /ID# 274364, Newport Beach, California
California Medical Research Associates /ID# 274787, Northridge, California
Clinical Applications Laboratories - San Diego - 3rd Avenue /ID# 273527, San Diego, California
Novum Research /ID# 273587, Clermont, Florida
Hillcrest Medical Research /ID# 273593, DeLand, Florida
Florida Research Institute /ID# 275196, Lakewood Ranch, Florida
Sanchez Clinical Research /ID# 273727, Miami, Florida
Sarkis Clinical Trials - Ocala /ID# 273595, Ocala, Florida
Endoscopic Research, Inc. /ID# 273548, Orlando, Florida
Digestive And Liver Center Of Florida - Orlando /ID# 276432, Orlando, Florida
Gi Alliance - Glenview /ID# 274270, Glenview, Illinois
Illinois Gastroenterology Group /ID# 274280, Gurnee, Illinois
Southwest Gastroenterology - Oak Lawn /ID# 273596, Oak Lawn, Illinois
Springfield Clinic Main Campus /ID# 273547, Springfield, Illinois
Gastroenterology Health Partners /ID# 276434, New Albany, Indiana
Cotton O'Neil Digestive Health Center /ID# 274394, Topeka, Kansas
Gastroenterology Health Partners, PLLC /ID# 276441, Louisville, Kentucky
Tandem Clinical Research - Houma /ID# 274562, Houma, Louisiana
Metropolitan Gastroenterology Associates - Metairie /ID# 274282, Metairie, Louisiana
Pinnacle Gastroenterology /ID# 274991, Shreveport, Louisiana
Louisiana Research Center, LLC /ID# 276443, Shreveport, Louisiana
Velocity Clinical Research, Rockville /ID# 273599, Rockville, Maryland
Gi Associates - Gia And Endoscopy Center - Flowood /ID# 274285, Flowood, Mississippi
Delta Gastroenterology & Endoscopy Center /ID# 275005, Southaven, Mississippi
New York Gastroenterology Associates - Upper East Side /ID# 273520, New York, New York
Digestive Health Partners - Biltmore Office /ID# 273594, Asheville, North Carolina
Carolina Digestive Diseases And Endoscopy Center /ID# 274256, Greenville, North Carolina
Digestive Disease Consultants - Brunswick /ID# 276445, Brunswick, Ohio
Gastro Health /ID# 275082, Cincinnati, Ohio
The Ohio State University - Wexner Medical Center /ID# 274743, Columbus, Ohio
Dayton Gastroenterology, Inc /ID# 273528, Dayton, Ohio
Digestive Disease Associates, LTD - Wyomissing /ID# 273603, Wyomissing, Pennsylvania
Gastroenterology Associates of Orangeburg /ID# 274559, Orangeburg, South Carolina
Gastro One - Walnut Run Road /ID# 273551, Cordova, Tennessee
GI associates of Northeast Tennessee /ID# 273758, Johnson City, Tennessee
Tri-Cities Gastroenterology /ID# 275067, Kingsport, Tennessee
Gastrointestinal Associates - Knoxville - Dowell Springs Boulevard /ID# 276447, Knoxville, Tennessee
Quality Medical Research /ID# 273733, Nashville, Tennessee
Amel Med /ID# 276439, Georgetown, Texas
Digestive & Liver Disease Consultants /ID# 276454, Houston, Texas
Caprock Gastro Research - Lubbock - 80th Street /ID# 273778, Lubbock, Texas
Linq Research /ID# 274917, Pearland, Texas
Tyler Research Institute, LLC /ID# 273585, Tyler, Texas
Care Access - Ogden /ID# 274361, Ogden, Utah
Gi Alliance - Bellevue /ID# 274264, Bellevue, Washington
Washington Gastroenterology - Tacoma /ID# 274551, Tacoma, Washington
Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 274318, Linz, Oberoesterreich
Medizinische Universitaet Graz /ID# 274428, Graz, Steiermark
Hospital Tsaritsa Yoanna /ID# 274723, Sofiya, Sofia
Acibadem City Clinic UMHAT Mladost /ID# 274804, Sofiya, Sofia
Umbal Kaspela /ID# 274721, Plovdiv, Not set
2nd Mhat /ID# 274722, Sofia, Not set
Mhat Doverie /ID# 274798, Sofia, Not set
Barrie GI Associates /ID# 275211, Barrie, Ontario
Toronto Immune & Digestive Health Institute /ID# 274259, Toronto, Ontario
Diex Recherche Quebec Inc. /ID# 274268, Quebec, Not set
Poliklinika Solmed /ID# 273323, Zagreb, Grad Zagreb
Poliklinika Borzan d.o.o. /ID# 273324, Osijek, Osjecko-baranjska Zupanija
Specialty Hospital Medico /ID# 273334, Rijeka, Primorsko-goranska Zupanija
Universitaetsklinikum Ulm /ID# 273411, Ulm, Baden-Wuerttemberg
Universitaetsklinikum Erlangen /ID# 273504, Erlangen, Bayern
Praxisgemeinschaft Jerichow Schulze /ID# 273433, Jerichow, Sachsen-Anhalt
Eugastro /ID# 273573, Leipzig, Sachsen
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 274545, Berlin, Not set
Krankenhaus Waldfriede /ID# 273708, Berlin, Not set
GSGH Gastroenterologische Studiengesellschaft Herne GbR /ID# 273459, Herne, Not set
Clinfan /ID# 274904, Szekszárd, Tolna
Our Lady of Lourdes Hospital - Drogheda /ID# 273783, Drogheda, Louth
Midland Regional Hospital Mullingar /ID# 273784, Mullingar, Westmeath
Assuta Ashdod Medical Center /ID# 274686, Ashdod, HaDarom
Yitzhak Shamir Medical Center /ID# 275525, Zerifin, HaMerkaz
The Chaim Sheba Medical Center /ID# 273348, Ramat Gan, Tel-Aviv
Tel Aviv Sourasky Medical Center /ID# 273351, Tel Aviv, Tel-Aviv
Rambam Health Care Campus /ID# 273347, Haifa, Not set
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 273590, Kaunas, Not set
Inlita - Lazdynai CTC /ID# 273725, Vilnius, Not set
WSD MEDI Clinical Sp. z o.o. /ID# 274194, Warsaw, Mazowieckie
Caribbean Medical Research Center /ID# 274832, San Juan, Not set
Fdi Clinical Research /ID# 275337, San Juan, Not set
General Hospital Celje /ID# 275127, Celje, Not set
University Medical Centre Ljubljana /ID# 273636, Ljubljana, Not set
Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 274266, Santiago de Compostela, A Coruna
Hospital Clinic de Barcelona /ID# 274262, Barcelona, Not set
Hospital Universitario Doctor Peset /ID# 274385, Valencia, Not set
Kantonsspital St.Gallen /ID# 273382, St. Gallen, Sankt Gallen
Inselspital, Universitaetsspital Bern /ID# 273364, Bern, Not set
China Medical University Hospital /ID# 273641, Taichung, Not set
Mackay Memorial Hospital /ID# 273643, Taipei City, Not set
Taipei Veterans General Hospital /ID# 274717, Taipei City, Not set
Velocity North London /ID# 275581, North Finchley, Greater London
Conditions: Ulcerative Colitis
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease
Recruiting
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease. Read Less
Gender:
ALL
Ages:
Between 10 years and 65 years
Trial Updated:
08/21/2025
Locations: Alabama Kidney Research, Alabaster, Alabama +313 locations
Alabama Kidney Research, Alabaster, Alabama
EmVenio Research - Mobile Unit - Birmingham, Birmingham, Alabama
Cardiology, P.C., Birmingham, Alabama
Children's Hospital of Alabama, Birmingham, Alabama
The Kirklin Clinic - Nephrology, Birmingham, Alabama
Nephrology Associates, Fairhope, Alabama
Heart Center Research LLC, Huntsville, Alabama
Nephrology Consultants, LLC, Huntsville, Alabama
Renal Associates of Alabama, LLC, Montgomery, Alabama
Phoenix Children's Hospital, Inc. - Nephrology, Phoenix, Arizona
CHI St. Vincent Heart Clinic Arkansas- Cardiology and Medicine Clinic - Little Rock, Little Rock, Arkansas
UAMS Medical Center - Pulmonology, Little Rock, Arkansas
The Medical Research Group - Saint Agnes Medical Center, Fresno, California
Amicis Research Center - Balboa, Granada Hills, California
Kidney Care Center of North Valley, Granada Hills, California
Eastside Clinical Research Associates, Los Angeles, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Cedars-Sinai Medical Center, Los Angeles, California
UCLA Division of Nephrology, Los Angeles, California
UCI Center for Clinical Research, Orange, California
Kaiser Permanente Sacramento Medical Center, Sacramento, California
Helen Diller Medical Center at Parnassus Heights, San Francisco, California
UCLA Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California
Kidney and Hypertension Center, Victorville, California
Greater Hartford Nephrology, Bloomfield, Connecticut
Nephrology & Hypertension Associates, PC, Middlebury, Connecticut
Yale University - Yale Nephrology Clinical Research Clinic, New Haven, Connecticut
Children's National Hospital - Nephrology, Washington, District of Columbia
The George Washington University - GW Medical Faculty Associates, Washington, District of Columbia
Veterans Affairs Medical Center - Washington D.C, Washington, District of Columbia
Bay Pines Foundation, Bay Pines, Florida
Nova Clinical Research, LLC - Bradenton - 59th St, Bradenton, Florida
Clinical Research of Brandon, LLC, Brandon, Florida
AMR-Miami, Coral Gables, Florida
Horizon Research Group - Coral Gables, Coral Gables, Florida
South Florida Nephrology Research, Coral Springs, Florida
Delray Physician Care Center, Delray Beach, Florida
North Florida/South Georgia Veterans Health System, Gainesville, Florida
Shands Hospital - Nephrology, Gainesville, Florida
Velocity Clinical Research - Hallandale Beach, Hallandale Beach, Florida
Qway Research, Hialeah, Florida
Elixia Pines, Hollywood, Florida
UF Health Cardiovascular Center - Jacksonville, Jacksonville, Florida
South Florida Research Institute, Lauderdale Lakes, Florida
South Florida Research, Miami Springs, Florida
Total Research Group, LLC, Miami, Florida
MedBio Trials, Miami, Florida
Cordova Research Institute, Miami, Florida
CTR Oakwater, LLC, Orlando, Florida
Synexus Clinical Research - Orlando, Orlando, Florida
Omega Research Orlando, LLC - Mercy Dr, Orlando, Florida
Infigo Clinical Research, Sanford, Florida
Genesis Clinical Research, Tampa, Florida
Elixia Tampa, Tampa, Florida
American Clinical Trials LLC - Acworth, Acworth, Georgia
Kaiser Permanente Georgia, Atlanta, Georgia
Emory School of Medicine - Renal Division, Atlanta, Georgia
Advanced Clinical Research of Atlanta, Atlanta, Georgia
Morehouse School of Medicine, Grady Memorial Hospital, Atlanta, Georgia
Emory Childrens Center - Nephrology, Atlanta, Georgia
Synexus Clinical Research - Atlanta (DRS), Atlanta, Georgia
Fides Clinical Research, Atlanta, Georgia
Augusta University Medical College of Georgia - Adult Sickle Cell Clinic, Augusta, Georgia
Coastal Medical Research, Brunswick, Georgia
Randomize Now - College Park, College Park, Georgia
Clincept - Veterans Pkwy., Columbus, Georgia
Renal Associates, Columbus, Georgia
Georgia Nephrology - Decatur, Decatur, Georgia
Atlanta VA Healthcare System, Decatur, Georgia
American Clinical Trials LLC - Douglasville, Douglasville, Georgia
Southeast Kidney Associates, East Point, Georgia
Javara Inc./Privia Medical Group - Fayetteville, GA, Fayetteville, Georgia
Georgia Nephrology - Lawrenceville - Billing Office, Lawrenceville, Georgia
Javara Inc./Privia Medical Group - Savannah, GA, Savannah, Georgia
Inova Clinical Trials and Research Center, Tyrone, Georgia
Rophe Adult and Pediatric Medicine, Union City, Georgia
Synexus Clinical Research - Chicago (DRS), Chicago, Illinois
EmVenio Research - Chicago, Chicago, Illinois
Ann & Robert H. Lurie Children's Hospital of Chicago - Nephrology, Chicago, Illinois
Northwestern Medical Group, Chicago, Illinois
UChicago Medicine - Comer Children's Hospital, Chicago, Illinois
NANI Research LLC - Evergreen Park IL, Evergreen Park, Illinois
Edward Hines Jr VA Hospital, Hines, Illinois
Essential Concepts Research Solutions, Palos Hills, Illinois
NANI Research LLC - Fort Wayne IN, Fort Wayne, Indiana
IU School of Medicine - Nephrology, Indianapolis, Indiana
Nephrology Physicians, LLC, Mishawaka, Indiana
University of Iowa Health Care Medical Center- Nephrology, Iowa City, Iowa
Clinical & Translational Science Unit (CTSU) - Nephrology, Kansas City, Kansas
Premier Clinical Research, Overland Park, Kansas
Renal Associates of Baton Rouge, Baton Rouge, Louisiana
LCMC Health, Metairie, Louisiana
Barnum Medical Research - Bienville St, Natchitoches, Louisiana
Louisiana Clinical and Translational Science (LA CaTS) Center, New Orleans, Louisiana
University Medical Center - New Orleans - Nephrology, New Orleans, Louisiana
Ochsner Medical Center - New Orleans, New Orleans, Louisiana
Northwest Louisiana Nephrology, LLC, Shreveport, Louisiana
Louisiana State University Health Shreveport, Shreveport, Louisiana
Monroe Research, LLC, West Monroe, Louisiana
Javara Inc./Privia Medical Group - Annapolis, MD, Annapolis, Maryland
University of Maryland Medical Center - General Clinical Research Center, Baltimore, Maryland
The Johns Hopkins University - Johns Hopkins Hospital - Nephrology, Baltimore, Maryland
Mid-Atlantic Permanente Research Institute, Gaithersburg, Maryland
Patient First Clinical Trials, Lutherville, Maryland
MD Medical Research, Oxon Hill, Maryland
Javara Inc./Privia Medical Group - Silver Spring, MD - Columbia Pike, Silver Spring, Maryland
Tufts Medical Center, Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
Beth Israel Deaconess Medical Center - Nephrology, Boston, Massachusetts
Whittier Street Health Center, Roxbury, Massachusetts
Renal and Transplant Associates of New England, PC, Springfield, Massachusetts
Kidney Care and Transplant Services of New England - West Springfield, West Springfield, Massachusetts
A. Alfred Taubman Health Care Center - Nephrology Clinic at Taubman Center, Ann Arbor, Michigan
Henry Ford Health System - Nephrology, Detroit, Michigan
Quest Research Institute, Farmington Hills, Michigan
AA Medical Research Center, Flint, Michigan
Sparrow Clinical Research Institute, Lansing, Michigan
St. Clair Nephrology Research, Roseville, Michigan
Center for Advanced Kidney Research, Saint Clair Shores, Michigan
InterMed Consultants - Edina Clinic, Edina, Minnesota
Minneapolis VA Healthcare System, Minneapolis, Minnesota
Nephrology Associates, P.C. - Columbus, Columbus, Mississippi
Prime Health and Wellness, Fayette, Mississippi
UMMC Grenada Hospital, Grenada, Mississippi
G.V. (Sonny) Montgomery VAMC, Jackson, Mississippi
Olive Branch Family Medical Center, Olive Branch, Mississippi
SKY Integrative Medical Center, Ridgeland, Mississippi
Nephrology and Hypertension Associates - Tupelo, Tupelo, Mississippi
Center for Specialized Medicine - Nephrology, Saint Louis, Missouri
Barnes-Jewish Center for Outpatient Health, Saint Louis, Missouri
St. Louis Children's Hospital - Nephrology, Saint Louis, Missouri
St. Louis Heart and Vascular, P.C., Saint Louis, Missouri
Nevada Kidney Disease and Hypertension Centers, Las Vegas, Nevada
DaVita Kidney Care - Las Vegas, Las Vegas, Nevada
CUH - Sheridan Pavilion - Three Cooper Plaza, Camden, New Jersey
Hackensack University Medical Center, Hackensack, New Jersey
Bioluminux Clinical Research New Jersey, Hamilton, New Jersey
Jersey Shore University Medical Center, Neptune, New Jersey
Rutgers Doctors Office Center, Newark, New Jersey
New Mexico VA Healthcare System, Albuquerque, New Mexico
Renal Medicine Associates, Albuquerque, New Mexico
Kidney Medical Associates, PLLC, Bronx, New York
Montefiore Einstein - Albert Einstein College of Medicine, Bronx, New York
Montefiore Einstein Hospital - Moses Campus, Bronx, New York
James J. Peters VA Medical Center, Bronx, New York
Kings County Hospital, Brooklyn, New York
SUNY Downstate Health Sciences University, Brooklyn, New York
Clindove Research LLC, Brooklyn, New York
New York Presbyterian Queens, Flushing, New York
Zucker School of Medicine, Great Neck, New York
Scott Research, Inc., Laurelton, New York
VA New York Harbor Healthcare System, New York, New York
Grossman School of Medicine, New York, New York
Synexus Clinical Research - New York (DRS), New York, New York
The Rogosin Kidney Center, New York, New York
Icahn School of Medicine at Mount Sinai - Nephrology, New York, New York
General Nephrology Clinic - New York City, New York, New York
NYC Health + Hospital/Harlem, New York, New York
North Carolina Nephrology P.A. - Cary, Cary, North Carolina
UNC Clinical and Translational Research Center, Chapel Hill, North Carolina
Metrolina Nephrology Associates - Freedom Dr, Charlotte, North Carolina
Duke University Hospital - Children's Health Center, Durham, North Carolina
Eastern Nephrology Associates - Greenville Office, Greenville, North Carolina
Eastern Nephrology Associates - Jacksonville Office, Jacksonville, North Carolina
Eastern Nephrology Associates - Kinston Office, Kinston, North Carolina
Eastern Nephrology Associates - New Bern Office, New Bern, North Carolina
Eastern Nephrology Associates - Wilmington Office, Wilmington, North Carolina
Brookview Hills Research Associates, Winston-Salem, North Carolina
UC - DCI McMillan Research Unit, Cincinnati, Ohio
Cincinnati VA Medical Center, Cincinnati, Ohio
Louis Stokes Cleveland VA medical Center, Cleveland, Ohio
UH Cleveland Medical Center - Nephrology, Cleveland, Ohio
Cleveland Clinic - Main Campus, Cleveland, Ohio
Ohio State University - Wexner Medical Center - Nephrology Clinical Trials Unit, Columbus, Ohio
Jefferson Health - 33 South 9th Street, Philadelphia, Pennsylvania
Lewis Katz School of Medicine at Temple University - Section of Nephrology, Philadelphia, Pennsylvania
Jefferson Einstein Philadelphia Hospital - Nephrology, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh - Nephrology, Pittsburgh, Pennsylvania
Lifespan Clinical Research Center, East Providence, Rhode Island
Pharmacorp Clinical Trials, Inc, Charleston, South Carolina
Medical University of South Carolina - Pulmonology, Charleston, South Carolina
Columbia Nephrology Associates, PA, Columbia, South Carolina
Carolina Nephrology, PA, Spartanburg, South Carolina
Southeast Renal Research Institute, Chattanooga, Tennessee
Le Bonheur Children's Hospital - Outpatient Clinic, Memphis, Tennessee
CNS Healthcare - Memphis, Memphis, Tennessee
Nashville General Hospital - Meharry Medical College - Nephrology, Nashville, Tennessee
Nashville VA Medical Center, Nashville, Tennessee
Nephrology Clinical Trials Center, Nashville, Tennessee
Dallas Renal Group - Mansfield, Arlington, Texas
Arlington Nephrology, Arlington, Texas
Baylor Scott and White Research Institute - Nephrology, Dallas, Texas
Dallas Renal Group- Dallas, Dallas, Texas
Zenos Clinical Research, Dallas, Texas
Nephrotex Research Group, Dallas, Texas
Dallas Renal Group - Liberty Dallas Dialysis Center, Dallas, Texas
Dallas Nephrology Associates - Dallas Landry Office, Dallas, Texas
Southwest Family Medicine Associates (SFMA) - Dallas, Dallas, Texas
UTSW Medical Center - Nephrology, Dallas, Texas
Davita Clinical Research - El Paso, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Prolato Clinical Research Center - Kirby Dr, Houston, Texas
Ronald Ralph MD PA, Houston, Texas
Houston Medical Research Institute, LLC, Houston, Texas
Clinical Research Strategies - Romano North Main Office, Houston, Texas
Frenova-Southwest Houston, Houston, Texas
NTKDA Lewisville, Lewisville, Texas
Prime Clinical Research Inc - Lewisville, Lewisville, Texas
Texas Tech University Health Sciences Center, Lubbock, Texas
Prime Clinical Research - Mansfield - Regency Parkway, Mansfield, Texas
San Antonio Kidney Disease Center Physicians Group - Medical Center, San Antonio, Texas
University of Texas Health Science Center - Nephrology, San Antonio, Texas
San Antonio Kidney Disease Center Physicians Group - Westover Hills, San Antonio, Texas
Kidney Specialists of N Houston, PLLC, Shenandoah, Texas
Renal Research of Montgomery County, PLLC, The Woodlands, Texas
Tranquil Clinical Research, Webster, Texas
UVA Health - Nephrology Clinical Research Center, Charlottesville, Virginia
Tidewater Kidney Specialists - Church St., Norfolk, Virginia
York Clinical Research, LLC, Norfolk, Virginia
McGuire Research Institute, Inc. (151), Richmond, Virginia
Virginia Commonwealth University - Division of Nephrology, Richmond, Virginia
Nephrology Associates of Tidewater, LTD, Virginia Beach, Virginia
UW Medical Center - Montlake - Nephrology, Seattle, Washington
Medical College of Wisconsin - Pulmonology, Milwaukee, Wisconsin
Milwaukee Nephrologists - Wauwatosa, Wauwatosa, Wisconsin
Universite Catholique de Louvain - Pulmonology, Woluwe-Saint-Lambert, Brussels
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg - Pulmonology, Leuven, Not set
Centro de Pesquisa Clinica do Coracao, Aracaju, Not set
Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Not set
Faculdade de Medicina de Botucatu - CKD and Hypertension Department, Botucatu, Not set
Faculdade de Medicina de Botucatu - Kidney Transplantation Department, Botucatu, Not set
IPECC - Instituto de Pesquisa Clinica de Campinas, Campinas, Not set
Instituto Pro-Renal, Curitiba, Not set
PUC Trials - Unidade Epicenter, Curitiba, Not set
Instituto de Ensino e Pesquisa Clinica do Ceara, Fortaleza, Not set
Walter Cantídio University Hospital, Fortaleza, Not set
Federal University of Goiás (UFG), Goiania, Not set
Cmip-Centro Mineiro de Pesquisa Ltda, Juiz de Fora, Not set
Galileo Medical Research Ltda, Juiz De Fora, Not set
ICM - Instituto do Coracao de Marilia, Marilia, Not set
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Monte Alegre, Not set
Dom Vicente Scherer Hospital, Porto Alegre, Not set
Hospital de Clínicas de Porto Alegre - Nephrology, Porto Alegre, Not set
Centro de Pesquisa Clinica Professor Salomao Kelner, Recife, Not set
Hospital São Lucas, Rio de Janeiro, Not set
Comlexo Hospitalar Universitário Professor Edgard Santos, Salvador, Not set
CSB Group of Nephrology Brazil, Salvador, Not set
Hospital Ana Nery/SESAB, Salvador, Not set
Praxis Pesquisa Medica, Santo Andre, Not set
Hospital Nove de Julho - Nephrology, Sao Paulo, Not set
Irmandade Da Santa Casa De Misericordia De Sao Paulo, Sao Paulo, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
Hospital das Clínicas da Faculdade de Medicina - Laboratório de Nefrologia Celular, Genética e Molecular, São Paulo, Not set
Hospital do Rim - Fundação Oswaldo Ramos, São Paulo, Not set
Recherche GCP Research, Montreal, Not set
Women's College Hospital, Toronto, Not set
Clinica de La Costa S.A.S, Atlántico, Not set
Solano & Terront Servicios Medicos SAS - Unidad Integral de Endocrinologia - UNIENDO, Bogota, Not set
Fundación Valle Del Lili, Cali, Not set
Centro Cardiovascular Aristides Sotomayor Santa Lucía SAS IPS, Cartagena, Not set
Mediservis del Tolima IPS S.A.S., Ibague, Not set
Promotora Medica Las Americas S.A. - Clinica Las Americas, Medellin, Not set
Fundación Hospitalaria San Vicente de Paul, Medellín, Not set
Hopital Henri Mondor - Nephrology, Créteil, Not set
Hospital Nord Michallon - Nephrology, Grenoble, Not set
Bicetre Hospital, Le Kremlin Bicêtre, Not set
CHU Dupuytren 2 - Néphrologie, dialyse, transplantations, Limoges, Not set
Hôpital de la Conception, Marseille, Not set
Ambroise Paré Hospital, Paris, Not set
Hopital Necker Enfants Malades - Nephrology, Paris, Not set
Hopital Tenon, Paris, Not set
Université Paris-Descartes / Hôpital Européen Georges Pompidou, Paris, Not set
CHU de Guadeloupe, Pointe-à-Pitre Cedex, Not set
AURA Nord, Saint-Ouen, Not set
Hopital de Rangueil, Toulouse, Not set
University of Ghana Medical School - Nephrology, Accra, Not set
The Bank Hospital, Cantonments, Not set
Komfo Anokye Teaching Hospital - Nephrology, Kumasi, Not set
Amsterdam UMC - Amsterdam Public Health Research Institute, Amsterdam, Not set
University of Nigeria Teaching Hospital, Enugu, Not set
University College Hospital, Ibadan, Not set
Lagos University Teaching Hospital, Idi-Araba, Not set
Lagos State University Teaching Hospital, Ikeja, Not set
Nigerian Institute of Medical Research, Lagos, Not set
Unidade Local de Saude Amadora/Sintra, E.P.E., Amadora, Not set
Hospital Curry Cabral - Serviço de Nefrologia, Lisboa, Not set
Unidade Local de Saúde de Santa Maria, E.P.E. - Nephrology, Lisboa, Not set
Unidade Local de Saúde de Loures-Odivelas, E.P.E., Loures, Not set
FDI Clinical Research, Mayaguez, Not set
University of Puerto Rico, Rio Piedras, Not set
GCM Medical Group, PSC, San Juan, Not set
Hospital Clinic de Barcelona - Nephrology, Barcelona, Not set
Hospital Universitari Vall d´Hebron - Servicio de Pediatria, Barcelona, Not set
Reina Sofia University Hospital - Nephrology, Córdoba, Not set
Hospital Universitario 12 de Octubre - Nephrology, Madrid, Not set
Hospital Universitario Virgen Macarena, Seville, Not set
Mid and South Essex Hospitals NHS Trust, Basildon, Not set
Synexus Clinical Research - Glasgow (DRS), Bellshill, Not set
FutureMeds Birmingham, Birmingham, Not set
Queen Elizabeth Hospital Birmingham, Birmingham, Not set
Synexus Clinical Research - Midlands (DRS), Birmingham, Not set
Epsom and St Helier University Hospitals NHS Trust, Carshalton, Not set
Leicester General Hospital, Leicester, Not set
Great Ormond Street Hospital for Children, London, Not set
Guy's Hospital - Endocrinology, London, Not set
King's College Hospital - Pulmonology, London, Not set
Royal Free Hospital - Nephrology, London, Not set
St George's Hospital London - Nephrology, London, Not set
St Pancras Clinical Research, London, Not set
The Royal London Hospital - Nephrology, London, Not set
Manchester Royal Infirmary - Endocrinology, Manchester, Not set
Synexus Clinical Research - NW Consortium Manchester (DRS), Manchester, Not set
Wythenshawe Hospital - Medicines Evaluation Unit, Manchester, Not set
Nottingham University Hospitals - Children's Clinical Research Facility - Pulmonology, Nottingham, Not set
Conditions: Proteinuric Kidney Disease
MAXPIRe: Study to Evaluate Axatilimab in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Recruiting
The study will evaluate the efficacy and safety of axatilimab in participants with IPF.
The study will evaluate the efficacy and safety of axatilimab in participants with IPF. Read Less
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/21/2025
Locations: Royal Prince Alfred Hospital, Camperdown, New South Wales +73 locations
Royal Prince Alfred Hospital, Camperdown, New South Wales
Sunshine Coast University Hospital, Birtinya, Queensland
Wallace Street Specialist Centre, Brisbane, Queensland
Mater Misericordiae Ltd, South Brisbane, Queensland
Griffith University Clinical Trial Unit, Southport, Queensland
Mackay Hospital & Health Service, West Mackay, Queensland
Monash Health, Clayton, Victoria
St Vincent's Melbourne, Fitzroy, Victoria
Institute for Respiratory Health, Perth, West Australia
OLV Hospital Aalst, Aalst, Oost-Vlaanderen
AZ Groeninge, Kortrijk, West-Vlaanderen
Centre de Recherche Clinique - CHUS, Sherbrooke, Quebec
Thomayer University Hospital, Prague, Not set
Chu Brest, Brest, Not set
CHU Dijon, Dijon, Not set
CHU de Rennes, Rennes, Not set
Klinikum Konstanz, Innere Medizin, Pneumologie, Konstanz, Baden-Wuerttemberg
Pneumologisches Studienzentrum München-West, Muenchen, Bavaria
Medizinische Hochschule Hannover, Hannover, Lower Saxony
Klinikum Chemnitz - Zentrum für klinische Studien, Chemnitz, Not set
Asklepios Lungenklinik Gauting, Gauting, Not set
Ospedale Colonnello D'Avanzo, Foggia, Apulie
GB Morgagni Hospital, Forlì, FC
ASST Santi Paolo e Carlo, Milano, Lombardia
San Gerardo, Monza, MB
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, MI
Azienda Ospedaliera Universitaria San Luigi Gonzaga, Torino, Orbassano
University of Padua, Padova, Padua
Azienda Ospedaliera Universitaria Senese, Siena, Tuscany
A.O.U. Policlinico "G. Rodolico - San Marco", Catania, Not set
Azienda Ospedaliero Universitaria di Careggi, Firenze, Not set
AOU di Modena, Modena, Not set
AOU Città della Salute e della Scienza di Torino - Molinette, Molinette, Not set
ISMETT, Palermo, Not set
Policlinico Tor Vergata Rome, Rome, Not set
Inje University Haeundae Paik Hospital, Haeundae, Busan
Chonnam National University Hospital, Gwangju, Dong-gu
The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Eunpyeong-gu
Konkuk University Medical Center, Seoul, Gwangjin-gu
Chung-Ang University Gwangmyeong Hospital, Gyeonggi-do, Gwangmyeong-si
Gachon University Gil Medical Center, Incheon, Namdong-gu
Asian Medical Center, Seoul, Songpa-gu
Jeonbuk National University Hospital, Jeonju, Not set
Korea University ANAM Hospital, Seoul, Not set
SoonChunHyang University Hospital, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Vitamed Galaj I Cichomski sp.j., Bydgoszcz, Kujawsko-Pomorskie
Mics Centrum Medyczne Bydgoszcz, Bydgoszcz, Not set
Warmia and Mazury Center for Lung Diseases, Olsztyn, Not set
Hospital Universitario Central de Asturias, Oviedo, Asturias
Hospital Universitario Bellvitge, Hospitalet de Llobregat, Barcelona
Hospital Universitario Parc Tauli, Sabadell, Barcelona
Hospital Universitario Marqués de Valdecilla, Santander, Cantabria
Hospital Universitario Puerta de Hierro, Majadahonda, Madrid
University Hospital Vall d'Hebron, Barcelona, Not set
Hospital Universitario Puerta del Mar - Pneumology and Thoracic Surgery Department, Cadiz, Not set
Giromed Institute, Girona, Not set
Hospital Arnau de Vilanova, Lleida, Not set
Hospital Gregorio Marañon, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Santiago de Compostela, Santiago De Compostela, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
E-Da Hospital, Kaohsiung, Not set
Chang-Geng Medical Foundation Linkou Chang-Geng Memorial Hospital, Linkou, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei city, Not set
Royal Papworth Hospital - Clincial Research Facility, Cambridge, Cambridgehsire
Norfolk and Norwich University Hospital, Norwich, Norfolk
Oxford University Hospitals NHS Trust, Oxford, Oxforshire
Gannochy Trust Clinical Research Suite, Perth, Scotland
Leeds Teaching Hospitals NHS Trust, Leeds, W York
University Hospitals Birmingham NHS Foundation Trust, Birmingham, West Midlands
Birmingham Heartlands Hospital, Birmingham, West Midlands
Hull University Teaching Hospitals NHS Trust (Castle Hill), Cottingham, YS
Conditions: Idiopathic Pulmonary Fibrosis
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Recruiting
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Local Institution - 0347, Birmingham, Alabama +328 locations
Local Institution - 0347, Birmingham, Alabama
Local Institution - 0581, Fullerton, California
Local Institution - 0202, Long Beach, California
Local Institution - 0643, Newport Beach, California
Local Institution - 0666, Orange, California
Local Institution - 0623, Santa Barbara, California
Local Institution - 0442, Denver, Colorado
Local Institution - 0651, Gainesville, Florida
Local Institution - 0621, Palm Bay, Florida
Local Institution - 0377, Tamarac, Florida
Local Institution - 0647, Tampa, Florida
Local Institution - 0392, Fort Eisenhower, Georgia
Local Institution - 0031, Marietta, Georgia
Local Institution - 0665, Arlington Heights, Illinois
Local Institution - 0423, Munster, Indiana
Local Institution - 0366, Edgewood, Kentucky
Local Institution - 0566, Louisville, Kentucky
Local Institution - 0644, Shreveport, Louisiana
Local Institution - 0385, Columbia, Maryland
Local Institution - 0019, Boston, Massachusetts
Local Institution - 0437, Worcester, Massachusetts
Local Institution - 0618, White Plains, New York
Local Institution - 0624, Asheville, North Carolina
Local Institution - 0672, Salisbury, North Carolina
Local Institution - 0620, Columbus, Ohio
Local Institution - 0657, York, Pennsylvania
Local Institution - 0658, Greenville, South Carolina
Local Institution - 0652, Laredo, Texas
Local Institution - 0622, San Antonio, Texas
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires
IDIM - Instituto de Investigaciones Metabólicas, Ciudad de Buenos Aires, Buenos Aires
Local Institution - 0584, Pilar, Buenos Aires
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0571, Buenos Aires, Ciudad Autónoma De Buenos Aires
Clinica Adventista Belgrano, Caba, Ciudad Autónoma De Buenos Aires
Sanatorio Plaza, Rosario, Santa Fe
Local Institution - 0126, Canberra, Australian Capital Territory
Tamworth Hospital, North Tamworth, New South Wales
Orange Hospital, Orange, New South Wales
Princess Alexandra Hospital, Brisbane, Queensland
Lyell McEwin Hospital, Elizabeth Vale, South Australia
Frankston Hospital, Frankston, Victoria
Northern Hospital, Melbourne, Victoria
Latrobe Regional Health, Traralgon, Victoria
Joondalup Health Campus, Joondalup, Western Australia
Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Kepler Universitätsklinikum, Linz, Not set
Medizinische Universität Wien, Wien, Not set
Local Institution - 0673, Wien, Not set
UZ Brussel, Brussels, Bruxelles-Capitale, Région De
Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De
Jessa Ziekenhuis, Hasselt, Limburg
AZ Maria Middelares, Gent, Oost-Vlaanderen
UZ Leuven, Leuven, Vlaams-Brabant
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set
Local Institution - 0257, Salvador, Bahia
Local Institution - 0242, Vitória, Espírito Santo
Local Institution - 0244, Belo Horizonte, Minas Gerais
Local Institution - 0235, Ijui, Rio Grande Do Sul
Local Institution - 0233, Porto Alegre, Rio Grande Do Sul
Local Institution - 0238, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0243, Porto Velho, Rondonia
Local Institution - 0237, Blumenau, Santa Catarina
Local Institution - 0245, Itajaí, Santa Catarina
Local Institution - 0240, Barretos, São Paulo
Local Institution - 0254, Sao Paulo, São Paulo
Local Institution - 0241, São Carlos, São Paulo
Local Institution - 0239, São José do Rio Preto, São Paulo
Local Institution - 0236, Rio de Janeiro, Not set
Local Institution - 0258, São Paulo, Not set
Local Institution - 0629, Panagyurishte, Pazardzhik
Local Institution - 0628, Sofia, Sofia (stolitsa)
Complex Oncology Center - Ruse EOOD, Ruse, Not set
Trakia Hospital, Stara Zagora, Not set
Local Institution - 0074, Halifax, Nova Scotia
Local Institution - 0559, Montreal, Quebec
Bradfordhill, Recoleta, Región Metropolitana De Santiago
FALP, Santiago, Región Metropolitana De Santiago
The First Afflilated Hospital of Bengbu Medical College, Bengbu, Anhui
Anhui Provincial Hospital, Hefei, Anhui
Beijing Cancer hospital, Beijing, Beijing
Local Institution - 0491, Beijing, Beijing
Local Institution - 0397, Beijing, Beijing
Chongqing University Cancer Hospital, Chongqing, Chongqing
Local Institution - 0362, Fuzhou Fujian, Fujian
The First Affiliated hospital of Xiamen University, Xiamen, Fujian
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong
Cancer Hospital of Shantou University Medical College, Shantou, Guangdong
Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center, Shenzhen, Guangdong
ShenZhen People's Hospital, Shenzhen, Guangdong
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi
Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang
Nanyang City Center Hospital, Nanyang, Henan
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Hubei
Local Institution - 0398, Changsha, Hunan
Local Institution - 0371, Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu
Northern Jiangsu People's Hospital, Yangzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
The First Hospital of Jilin University, Changchun, Jilin
The First Hospital of China Medical University, Shenyang, Liaoning
Shengjing Hospital of China Medical University, Shenyang, Liaoning
Local Institution - 0493, Shenyang, Liaoning
Shandong Cancer Hospital, Jinan, Shandong
LinYi Cancer Hospital, Linyi, Shandong
Local Institution - 0470, Shanghai, Shanghai
Local Institution - 0381, Shanghai, Shanghai
Shanxi Cancer Hospital, Taiyuan, Shanxi
West China Hospital, Sichuan University, Cheng Du, Sichuan
Sichuan Cancer hospital, Chengdu, Sichuan
Tianjin Medical University General Hospital, Tianjin, Tianjin
Local Institution - 0462, Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang
Shanghai East Hospital, Shanghai, Not set
Local Institution - 0580, Medellín, Antioquia
Local Institution - 0171, Rionegro, Antioquia
Local Institution - 0191, Puerto Colombia, Atlántico
Local Institution - 0253, Valledupar, Cesar
Local Institution - 0167, Montería, COR
Local Institution - 0671, Bogota, Cundinamarca
Local Institution - 0189, Bogotá, Distrito Capital De Bogotá
Local Institution - 0170, Floridablanca, Santander
Local Institution - 0173, Cali, Valle Del Cauca
Local Institution - 0619, Dubrovnik, Dubrovačko-neretvanska Županija
Local Institution - 0664, Rijeka, Primorsko-goranska Županija
Local Institution - 0639, Split, Splitsko-dalmatinska Županija
Local Institution - 0567, Osijek, Not set
Local Institution - 0585, Zagreb, Not set
Local Institution - 0159, Mulhouse, Alsace
Centre François Baclesse, Caen, Calvados
Centre Georges François Leclerc, Dijon, Côte-d'Or
CHRU de Brest, Brest, Finistère
Institut Régional du Cancer Montpellier, Montpellier, Hérault
Chu Grenoble Alpes, La Tronche, Isère
Local Institution - 0560, Angers, Maine-et-Loire
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Meurthe-et-Moselle
Local Institution - 0636, Marseille, Provence-Alpes-Côte-d'Azur
CHU d'Amiens-Picardie - Hôpital Sud, Amiens, Somme
Gustave Roussy, Villejuif, Val-de-Marne
Hôpital Ambroise Paré, Boulogne-Billancourt, Not set
Chu Gabriel Montpied, Clermont-Ferrand, Not set
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren, Limoges, Not set
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Local Institution - 0133, Paris, Not set
Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris, Not set
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes, Saint-Herblain, Not set
Klinikum Esslingen, Esslingen, Baden-Württemberg
Local Institution - 0670, Ulm, Baden-Württemberg
Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München, Bayern
Centrum für Hämatologie und Onkologie Bethanien, Frankfurt, Hessen
Local Institution - 0535, Gießen, Hessen
Praxis Onkologie am Raschplatz, Hannover, Niedersachsen
Pius Hospital Oldenburg, Oldenburg, Niedersachsen
Evangelisches Krankenhaus Herne - Eickel, Herne, Nordrhein-Westfalen
Klinikum Köln-Merheim, Köln, Nordrhein-Westfalen
Local Institution - 0522, Halle, Sachsen-Anhalt
Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Schleswig-Holstein
Local Institution - 0524, Gera, Thüringen
Universitätsklinikum Jena, Jena, Thüringen
Vivantes Klinikum Neukölln, Berlin, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Local Institution - 0675, Halle, Not set
Local Institution - 0528, Hemer, Not set
Local Institution - 0517, Stuttgart, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
Errikos Dunant Hospital Center, Athens, Attikí
Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí
University General Hospital of Larissa, Larissa, Thessalía
Queen Mary Hospital, Hksar, Not set
Queen Mary Hospital, Hksar, Not set
Local Institution - 0144, Gyöngyös, Heves
Local Institution - 0157, Tatabánya, Komárom-Esztergom
Local Institution - 0593, Kaposvár, Somogy
Local Institution - 0143, Farkasgyepu, Veszprém
Local Institution - 0151, Budapest, Not set
Local Institution - 0140, Budapest, Not set
Petz Aladar Egyetemi Oktato Korhaz, Győr, Not set
Local Institution - 0222, Visakhapatnam, Andhra Pradesh
Local Institution - 0312, New Delhi, Delhi
Local Institution - 0511, New Delhi, Delhi
Local Institution - 0135, New Delhi, Delhi
Local Institution - 0136, Ahmedabad, Gujarat
Local Institution - 0230, Ahmedabad, Gujarat
Local Institution - 0155, Thiruvananthapuram, Kerala
Local Institution - 0154, Mumbai, Maharashtra
Local Institution - 0226, Bhubaneswar, Odisha
Local Institution - 0224, Madurai, Tamil Nadu
Local Institution - 0663, Hyderabad, Telangana
Local Institution - 0153, Varanasi, Uttar Pradesh
Local Institution - 0161, Howrah, West Bengal
Local Institution - 0221, Kolkata, West Bengal
Local Institution - 0661, Hyderabad, Not set
Local Institution - 0102, Cork, Not set
Mater Private Hospital - Dublin, Dublin, Not set
St. James's Hospital, Dublin, Not set
Local Institution - 0100, Dublin, Not set
Beaumont Hospital, Dublin, Dublin, Not set
Rabin Medical Center, Petah Tikva, HaMerkaz
Sheba Medical Center, Ramat Gan, HaMerkaz
Yitzhak Shamir Medical Center, Zerifin, HaMerkaz
Hadassah Medical Center, Jerusalem, Yerushalayim
Local Institution - 0613, Haifa, Ḥeifā
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna
A.O.R.N. Ospedale dei Colli - Monaldi V., Naples, Napoli
Local Institution - 0070, Orbassano, Piemonte
Local Institution - 0071, Bari, Puglia
Local Institution - 0068, Rome, Roma
Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana
Ospedale San Martino, Genova, Not set
Local Institution - 0073, Padova, Not set
Local Institution - 0156, Parma, Not set
Local Institution - 0543, Pavia, Not set
Local Institution - 0556, Varese, Not set
Local Institution - 0607, Nagoya, Aichi
Local Institution - 0305, Nagoya, Aichi
Local Institution - 0298, Sapporo, Hokkaido
Local Institution - 0304, Kanazawa, Ishikawa
Local Institution - 0302, Sagamihara, Kanagawa
Local Institution - 0369, Yokohama, Kanagawa
Local Institution - 0301, Sendai, Miyagi
Local Institution - 0306, Kashihara, Nara
Local Institution - 0368, Kurashiki, Okayama
Local Institution - 0642, Hirakata, Osaka
Local Institution - 0303, Hidaka, Saitama
Local Institution - 0300, Ina-machi, Saitama
Local Institution - 0606, Hamamatsu, Shizuoka
Local Institution - 0299, Shimotsuga, Tochigi
Local Institution - 0674, Bunkyo ku, Tokyo
Local Institution - 0343, Toyoma, Toyama
Local Institution - 0542, Iwakuni, Yamaguchi
Local Institution - 0307, Akashi, Not set
Local Institution - 0346, Aomori, Not set
Local Institution - 0310, Fukuoka, Not set
Local Institution - 0367, Fukushima, Not set
Local Institution - 0308, Kumamoto, Not set
Local Institution - 0297, Osaka, Not set
Local Institution - 0309, Osaka, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Gachon University Gil Medical Center, Namdong-gu, Incheon-gwangyeoksi [Incheon]
Pusan National University Yangsan Hospital, Yangsan, Kyǒngsangnam-do
Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]
Konkuk University Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Korea University Guro Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0583, Saltillo, Coahuila
Local Institution - 0176, Mexico City, DIF
Local Institution - 0579, Pachuca, Hidalgo
Local Institution - 0178, Guadalajara, Jalisco
Local Institution - 0591, Monterrey, Nuevo León
Local Institution - 0175, Chihuahua, Not set
Local Institution - 0181, Puebla, Not set
Local Institution - 0638, Puebla, Not set
Local Institution - 0180, Veracruz, Not set
Local Institution - 0615, Maastricht, Limburg
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL), Amsterdam, Noord-Holland
Local Institution - 0205, Wrocław, Dolnośląskie
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie, Lublin, Lubelskie
Szpital Specjalistyczny im. Henryka Klimontowicza, Gorlice, Małopolskie
Pratia MCM Krakow, Kraków, Małopolskie
Med-Polonia Sp. z o. o., Poznan, Wielkopolskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set
Local Institution - 0078, Katowice, Not set
Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Not set
Local Institution - 0509, Lisbon, Lisboa
Instituto Portugês de Oncologia de Coimbra Francisco Gentil, Coimbra, Not set
Centro Hospitalar do Porto - Hospital de Santo António, Porto, Not set
SC Memorial Healthcare International SRL, Bucharest, București
Institutul Oncologic Bucuresti, Bucharest, București
Cardiomed SRL Cluj-Napoca, Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL, Florești, Cluj
Ovidius Clinical Hospital OCH, Ovidiu, Constanța
Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj
Spitalul Municipal Schuller Ploiești, Ploiești, Prahova
Cabinet Medical Oncomed, Timișoara, Timiș
Institutul Oncologic Cluj, Cluj, Not set
Institutul Oncologic Cluj, Cluj, Not set
Affidea Constanța, Constanța, Not set
S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set
Institutul Regional de Oncologie, Iași, Not set
Local Institution - 0614, Jeddah, Makkah Al Mukarramah
Local Institution - 0602, Riyadh, Not set
Local Institution - 0562, Riyadh, Not set
Local Institution - 0499, A Coruña, A Coruña [La Coruña]
Local Institution - 0506, Santiago de Compostela, A Coruña [La Coruña]
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]
Local Institution - 0497, Hospitalet, Barcelona [Barcelona]
Local Institution - 0505, Barcelona, Catalunya [Cataluña]
Hospital Son Llàtzer, Palma, Illes Balears [Islas Baleares]
Hospital General Universitario Gregorio Marañon, Madrid, Madrid, Comunidad De
Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Local Institution - 0669, Pontevedra, Pontevedra [Pontevedra]
Hospital Arnau de Vilanova, Valencia, València
Hospital Clinico San Carlos, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Local Institution - 0495, València, Not set
Kantonsspital Münsterlingen - Spital Thurgau AG, Münsterlingen, Not set
Chi Mei Hospital - Liouying Branch, Tainan City, Tainan
Tri-Service General Hospital, Taipei City, Taipei
Taipei Medical University Shuang Ho Hospital, New Taipei, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Local Institution - 0565, Muang, Khon Kaen
Local Institution - 0563, Bangkok, Krung Thep Maha Nakhon
Local Institution - 0564, Hatyai, Songkhla
Local Institution - 0548, Stanbul, İstanbul
Local Institution - 0199, Izmir, Karsiyaka, İzmir
Local Institution - 0197, Adana, Not set
Local Institution - 0201, Ankara, Not set
Local Institution - 0194, Ankara, Not set
Local Institution - 0198, Ankara, Not set
Local Institution - 0550, Istanbul, Not set
Local Institution - 0549, Istanbul, Not set
Local Institution - 0200, Izmir, Not set
University College London Hospital, London, London, City Of
Guy's & St Thomas' NHS Foundation Trust, London, London, City Of
Heartlands Hospital, Birmingham, Not set
Local Institution - 0545, Guildford, Not set
The Royal Surrey County Hospital, Guildford, Not set
Local Institution - 0093, Manchester, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma (GOLSEEK-4)
Recruiting
The study is designed as a multicenter, randomized, open label Phase 3 study to compare the efficacy and safety of golcadomide in combination with rituximab vs investigator's choice in participants with relapsed/refractory follicular lymphoma who have received at least one line of prior systemic therapy.
The study is designed as a multicenter, randomized, open label Phase 3 study to compare the efficacy and safety of golcadomide in combination with rituximab vs investigator's choice in participants with relapsed/refractory follicular lymphoma who have received at least one line of prior systemic therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Local Institution - 0225, Birmingham, Alabama +153 locations
Local Institution - 0225, Birmingham, Alabama
Local Institution - 0014, Mobile, Alabama
Alaska Oncology and Hematology, Anchorage, Alaska
Local Institution - 0215, Little Rock, Arkansas
Local Institution - 0072, Duarte, California
Local Institution - 0119, San Francisco, California
Local Institution - 0008, Jacksonville, Florida
Local Institution - 0214, Tampa, Florida
Local Institution - 0217, Tampa, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Marietta, Georgia
Local Institution - 0245, Newnan, Georgia
Local Institution - 0240, Arlington Heights, Illinois
Local Institution - 0253, Iowa City, Iowa
Local Institution - 0243, Waukee, Iowa
Local Institution - 0216, Westwood, Kansas
Local Institution - 0218, Lexington, Kentucky
Local Institution - 0023, Baltimore, Maryland
Greater Baltimore Medical Center, Towson, Maryland
Local Institution - 0145, Boston, Massachusetts
Local Institution - 0244, Boston, Massachusetts
Local Institution - 0247, Boston, Massachusetts
Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi
Local Institution - 0144, Providence, Rhode Island
Local Institution - 0237, Austin, Texas
Local Institution - 0212, Fort Worth, Texas
Local Institution - 0230, San Antonio, Texas
Local Institution - 0236, Tyler, Texas
Local Institution - 0238, Fairfax, Virginia
Hematology Oncology Associates of Fredericksburg, Fredericksburg, Virginia
Local Institution - 0146, Roanoke, Virginia
Local Institution - 0143, Vancouver, Washington
Local Institution - 0134, Westmead, New South Wales
Local Institution - 0132, Adelaide, South Australia
Local Institution - 0131, Hobart, Tasmania
Local Institution - 0128, Heidelberg, Victoria
Local Institution - 0198, Malvern, Victoria
Local Institution - 0127, Perth, Western Australia
Local Institution - 0224, Perth, Western Australia
Local Institution - 0159, Vitoria, Espírito Santo
Local Institution - 0088, Niterói, Rio De Janeiro
Local Institution - 0087, Porto Alegre, Rio Grande Do Sul
Local Institution - 0079, Sao Paulo, São Paulo
Local Institution - 0089, Rio de Janeiro, Not set
Local Institution - 0066, São Paulo, Not set
Local Institution - 0092, São Paulo, Not set
Local Institution - 0200, Victoria, British Columbia
Princess Margaret Cancer Centre, Toronto, Ontario
Local Institution - 0250, Québec, Quebec
Local Institution - 0192, Sherbrooke, Quebec
Local Institution - 0226, Sherbrooke, Quebec
Local Institution - 0154, Santiago, Región Metropolitana De Santiago
Local Institution - 0155, Santiago, Región Metropolitana De Santiago
Local Institution - 0153, Santiago, Región Metropolitana De Santiago
Local Institution - 0246, Beijing, Beijing
Local Institution - 0171, Beijing, Beijing
Local Institution - 0172, Fuzhou Fujian, Fujian
Local Institution - 0173, Guangzhou, Guangdong
Local Institution - 0241, Harbin, Heilongjiang
Local Institution - 0176, Wuhan, Hubei
Local Institution - 0175, Changsha, Hunan
Local Institution - 0235, Hohhot, Inner Mongolia
Local Institution - 0233, Suzhou, Jiangsu
Local Institution - 0178, Nanchang, Jiangxi
Local Institution - 0239, Changchun, Jilin
Local Institution - 0177, Changchun, Jilin
Local Institution - 0179, Shenyang, Liaoning
Local Institution - 0242, Shenyang, Liaoning
Local Institution - 0180, Jinan, Shandong
Local Institution - 0181, Shanghai, Shanghai
Local Institution - 0249, Shanghai, Shanghai
Local Institution - 0234, Sichuan, Sichuan
Local Institution - 0182, Tianjin, Tianjin
Local Institution - 0227, Tianjin, Tianjin
Local Institution - 0248, Kunming, Yunnan
Local Institution - 0184, Hangzhou, Zhejiang
Local Institution - 0174, Zhengzhou, Not set
Local Institution - 0151, Oulu, Pohjois-Pohjanmaa
Local Institution - 0152, Turku, Varsinais-Suomi
Local Institution - 0150, Helsinki, Not set
Local Institution - 0100, Pessac, Aquitaine
Local Institution - 0044, Saint-Cloud, Hauts-de-Seine
Local Institution - 0047, Montpellier, Languedoc-Roussillon
Local Institution - 0120, Nantes, Loire-Atlantique
Local Institution - 0048, Lille, Nord
Local Institution - 0042, Pierre-Bénite, Rhône
Local Institution - 0191, Paris, Not set
Local Institution - 0121, Toulouse, Not set
Local Institution - 0163, Ulm, Baden-Württemberg
Local Institution - 0161, Augsburg, Bayern
Local Institution - 0220, Göttingen, Niedersachsen
Local Institution - 0166, Dortmund, Nordrhein-Westfalen
Local Institution - 0193, Düsseldorf, Nordrhein-Westfalen
Local Institution - 0231, Münster, Nordrhein-Westfalen
Local Institution - 0232, Münster, Nordrhein-Westfalen
Local Institution - 0164, Homburg, Saarland
Local Institution - 0165, Chemnitz, Sachsen
Local Institution - 0222, Erfurt, Thüringen
Local Institution - 0167, Jena, Thüringen
Local Institution - 0187, Dresden, Not set
Local Institution - 0162, München, Not set
Local Institution - 0221, Wuerzburg, Not set
Local Institution - 0109, Athens, Attikí
Local Institution - 0107, Αthens, Attikí
Local Institution - 0110, Thessaloniki, Thessaloníki
Local Institution - 0197, Thessaloniki, Thessaloníki
Local Institution - 0111, Alexandroupolis, Not set
Local Institution - 0108, Ioannina, Ípeiros
Local Institution - 0142, New Delhi, Delhi
Local Institution - 0139, Bengaluru, Karnataka
Local Institution - 0141, Mumbai, Maharashtra
Local Institution - 0140, Hyderabad, Telangana
Local Institution - 0138, Hyderabad, Telangana
Local Institution - 0104, Bologna, Emilia-Romagna
Local Institution - 0101, Meldola, Emilia-Romagna
Local Institution - 0103, Rozzano, Milano
Local Institution - 0106, Pisa, Toscana
Local Institution - 0102, Alessandria, Not set
Local Institution - 0105, Napoli, Not set
Local Institution - 0157, Torino, Not set
Aiiku Hospital, Sapporo, Hokkaido
Japanease Red Cross Society Himeji Hospital, Himeji, Hyogo
Local Institution - 0201, Morioka, Iwate
University of Yamanashi Hospital, Chuo, Yamanashi
Local Institution - 0059, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0060, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0061, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0058, Seoul, Not set
Local Institution - 0050, Amsterdam, Noord-Holland
Local Institution - 0046, Groningen, Not set
Local Institution - 0053, Utrecht, Not set
Local Institution - 0188, Warszawa, Mazowieckie
Local Institution - 0186, Kraków, Małopolskie
Local Institution - 0190, Gdynia, Pomorskie
Local Institution - 0185, Skórzewo, Wielkopolskie
Local Institution - 0189, Łódź, Łódzkie
Local Institution - 0099, Dammam, Ash Sharqīyah
Local Institution - 0054, Riyadh, Not set
Local Institution - 0052, Riyadh, Not set
Local Institution - 0158, Sabadell, Barcelona [Barcelona]
Local Institution - 0122, Santander, Cantabria
Local Institution - 0124, Madrid, Madrid, Comunidad De
Local Institution - 0125, Valencia, Valenciana, Comunitat
Local Institution - 0126, Granada, Not set
Local Institution - 0123, Madrid, Not set
Local Institution - 0195, Istanbul- Fatih, İstanbul
Local Institution - 0194, Ankara, Not set
Local Institution - 0196, Antalya, Not set
Local Institution - 0223, Mersin, Not set
Local Institution - 0251, Abu Dhabi, Abū Z̧aby
Local Institution - 0252, Abu Dhabi, Abū Z̧aby
Norfolk and Norwich University Hospitals NHS Foundation Trust, Cringleford, England
Kent and Canterbury Hospital, Canterbury, Kent
Local Institution - 0213, London, London, City Of
Local Institution - 0149, Manchester, Not set
Conditions: Follicular Lymphoma
49 - 60 of 3097