All Clinical Trials in United Kingdom

A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders

NCT06722781

Recruiting

The goal of this clinical trial is to understand how to deliver online group therapy for adults with common mental health problems in a personalised way. This study will test a new online group therapy program for various common mental health problems like anxiety and depression. The therapy is based on an approach called the Unified Protocol, which includes eight modules teaching different coping skills. The therapy will be delivered via a video call and a website, which will also have helpful videos and information about coping skills. Aims: 1. Does changing the order of the therapy modules affect how well treatment works or how many patients drop-out of treatment? 2. Do some modules work better for different patients based on their individual features and if patients receive the therapy module that is most likely to be helpful for them first, does it mean they have a better chance of feeling better by the end of treatment? 3. Does online group therapy work as well to treat common mental health problems as standard care (individual cognitive behavioural therapy \[CBT\])? Hypotheses: 1. Changing the order of therapy modules will not change how well therapy works or how many people drop-out. 2. Patients with specific profiles (based on their individual characteristics) will benefit more from some treatment modules and will see greater improvements in their symptoms if they received their best therapy module before other modules 3. There will be no differences in overall treatment outcome or dropout rates when comparing online group therapy vs. individual CBT Researchers will compare whether delivering the modules in different orders, with five different versions of the treatment, to see if changing the order of therapy modules affects how well it works or drop-out rates. Researchers will test how best to match patients to the most helpful parts of treatment for them. The group therapy outcomes and costs will also be compared to data from patients who have had individual CBT to see how the intervention compares to standard care. Participants will: * Complete online symptom questionnaires before treatment starts and before each therapy session * Attend 12 weekly group therapy sessions delivered by a video call on a website (called Uplift-X). * Access online resources like videos and practice exercises to use between therapy sessions. * Complete the online symptom questionnaires again at the end of treatment and 6 months later. Read Less

Gender:

ALL

Ages:

17 years and above

Trial Updated:

07/07/2025

Locations: Rotherham Doncaster and South Humber NHS Foundation Trust, Doncaster, South Yorkshire +1 locations

Conditions: Common Mental Health Problems, Anxiety, Depression Disorders

Learn More ›

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

NCT05509777

Recruiting

Study participants will be screened during the platform study and randomly assigned to receive mirikizumab or another intervention. The purpose of the mirikizumab study is to evaluate efficacy, safety, tolerability, and how well mirikizumab absorbs into the body of pediatric participants with Crohn's disease. Study periods for the intervention-specific appendix (ISA) will be as follows: * A 12-week induction period * A maintenance period from Week 12 to Week 52, and * A safety follow-up period... Read More

Gender:

ALL

Ages:

Between 2 years and 17 years

Trial Updated:

07/07/2025

Locations: University of California San Diego, La Jolla, California +82 locations

University of California San Diego, La Jolla, California

Cedars Sinai Medical Center, Los Angeles, California

Connecticut Children's Medical Center, Hartford, Connecticut

Emory University, Atlanta, Georgia

Children's Center for Digestive Health Care, LLC, Atlanta, Georgia

Riley Childrens Hospital, Indianapolis, Indiana

Boston Children's Hospital, Boston, Massachusetts

Atlantic Children's Health--Pediatric Gastroenterology, Morristown, New Jersey

Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC), New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University Medical Center/New York Presbyterian, New York, New York

Childrens Medical Center, Dayton, Ohio

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Cook Children's Medical Center, Fort Worth, Texas

University of Vermont Medical Center, Burlington, Vermont

Seattle Children's Hospital, Seattle, Washington

AKH - Medizinische Universtität Wien, Vienna, Not set

Cliniques universitaires Saint-Luc, Bruxelles, Brussel

UZ Leuven, Leuven, Vlaams-Brabant

Universitair Ziekenhuis Brussel, Brussel, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Integral Pesquisa e Ensino, Votuporanga, Sao Paulo

Hospital PUC-CAMPINAS, Campinas, São Paulo

Hospital Pequeno Príncipe, Curitiba-PR, Not set

Hospital das Clínicas - UFG (Universidade Federal de Goiás), Goiânia, Not set

Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set

NDI - Nucleo de Doenças Infecciosas, Santos Dumont, Not set

Children's & Women's Health Centre of British Columbia, Vancouver, British Columbia

IWK Health Centre, Halifax, Nova Scotia

London Health Sciences Centre (LHSC) - Victoria Hospital, London, Ontario

The Hospital for Sick Children, Toronto, Ontario

Hopital Jeanne de Flandre - CHRU Lille, Lille Cedex, Nord

CHU AMIENS Picardie Site SUD CRC, Amiens, Not set

URC CIC, Paris, Not set

Hôpital Robert Debré - Paris, Paris, Not set

Kaplan Medical Center, Pediatric Gastroenterology Dept., Rehovot, Central Dsitrict Of Israel

Soroka Medical Center, Beer Sheva, Not set

Shamir Medical Center (Assaf Harofeh), Israel, Not set

Shaare Zedek, Jerusalem, Not set

Hadassah University Hospital, Ein Kerem,, Jerusalem, Not set

Schneider Children's Medical Center, Petah Tiqva, Not set

Asst Papa Giovanni Xxiii Bergamo, Bergamo, Not set

Azienda USL di Bologna, Bologna, Not set

SOC Gastroenterologia e Nutrizione - AOU Meyer (Primo Piano Ala OVEST, accettazione DH centralizzato), Firenze, Not set

Ospedale dei Bambini Vittore Buzzi, Milano, Not set

Ospedale Pediatrico Bambino Gesù, Roma, Not set

Gastroenterologia ed epatologia pediatrica (Piano terra della Clinica Pediatrica), Roma, Not set

Hirosaki University Hospital, Hirosaki, Aomori Pref.

Kokikai Tsujinaka Hospital Kashiwanoha, Kashiwa-shi, Chiba-Ken

Kobe University Hospital, Kobe, Hyogo

Yokohama City University Medical Center, Center of IBD, Yokohama-shi, Kanagawa-Ken

Miyagi Children's Hospital, Sendai-shi, Miyagi

Juntendo University Hospital, Bunkyo-ku, Tokyo

National Center for Child Health and Development, Setagaya-ku, Tokyo

Saga University Hospital, Saga, Not set

Kyungpook National University Chilgok Hospital, Daegu, Gyeongsangbuk-do

Samsung Medical Center, Seoul, Korea

Inje University Haeundae Paik Hospital, Busan, Kwangyǒkshi

Seoul National University Hospital, Seoul, Teukbyeolsi [Seoul]

Severance Hospital, Yonsei University Health System, Seoul, Not set

Erasmus Medisch Centrum, Rotterdam, Zuid-Holland

Akershus Universitetssykehus, Nordbyagen, Not set

Oslo University Hospital, Oslo, Not set

Universitetssykehuset Nord-Norge, Tromsø, Not set

St-Olavs Hospital, Trondheim, Not set

Instytut Pomnik-Centrum Zdrowia Dziecka, Warszawa, Masovian

Uniwersytecki Szpital Dziecięcy w Krakowie, Krakow, Not set

Korczowski Bartosz, Gabinet Lekarski, Rzeszow, Not set

Warsaw IBD Point Profesor Kierkus, Warszawa, Not set

Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga), Braga, Not set

Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisboa, Not set

Centro Hospitalar de São João, E.P.E., Porto, Not set

Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona

Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona

Hospital Universitario Reina Sofia, Cordoba, Not set

Hospital Universitari i Politecnic La Fe, València, Not set

Royal London Hospital, Whitechapel, Greater London

Great Ormond Street Hospital For Children NHS Foundation Trust, London, London, City Of

Royal Hospital for Children and Young People, Edinburgh, Lothian Region

Oxford University Hospitals NHS trust John Radcliffe hospital, Headington, Oxford

Sheffield Children's Hospital, Sheffield, South Yorkshire

Manchester University NHS Foundation Trust, Manchester, Not set

Conditions: Crohn's Disease

Learn More ›

RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty

NCT04095637

Recruiting

The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control. Patients receiving the Mako robotic UKA (Stryker Ltd) will form the investigation group and those undergoing the jig-based Oxford UKA (Zimmer-Biomet Ltd) with navigation control will form the control group. The primary objective in this study is to compare accuracy of compone... Read More

Gender:

ALL

Ages:

Between 40 years and 80 years

Trial Updated:

07/07/2025

Locations: UCL Hospital NHS Foundation Trust, London, Not set

Conditions: Unicompartmental Knee Replacement, Osteo Arthritis Knee, Surgery

Learn More ›

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

NCT03093116

Recruiting

Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with advanced solid malignancies harboring an ALK, ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. Midazolam DDI substudy will examine effect of of repotrectinib on CYP3A induction. Phase 2 will determine the confirmed Overall Response Rate (ORR) as assessed by Blin... Read More

Gender:

ALL

Ages:

12 years and above

Trial Updated:

07/07/2025

Locations: Local Institution - 2129, Duarte, California +164 locations

Local Institution - 2129, Duarte, California

Local Institution - 2120, Glendale, California

Local Institution - 2136, La Jolla, California

Local Institution - 2114, La Jolla, California

Local Institution - 2121, Long Beach, California

Local Institution - 2101, Orange, California

University of California Irvine Medical Center, Orange, California

Local Institution - 2126, Santa Rosa, California

Local Institution - 1003, Aurora, Colorado

Local Institution - 2103, Aurora, Colorado

Local Institution - 2106, Washington, District of Columbia

Local Institution - 2110, Washington, District of Columbia

Local Institution - 2128, Hollywood, Florida

Local Institution - 2113, Tampa, Florida

Local Institution - 2139, Athens, Georgia

Local Institution - 2134, Columbus, Georgia

Local Institution - 2125, Chicago, Illinois

Local Institution - 2142, Peoria, Illinois

Local Institution - 2116, New Orleans, Louisiana

Local Institution - 2133, Baltimore, Maryland

Local Institution - 2104, Boston, Massachusetts

Local Institution - 1004, Boston, Massachusetts

Local Institution - 2131, Boston, Massachusetts

Local Institution - 2105, Ann Arbor, Michigan

Local Institution - 2111, Detroit, Michigan

Local Institution - 2140, Detroit, Michigan

Local Institution - 2132, Saint Paul, Minnesota

Local Institution - 2147, Bolivar, Missouri

Local Institution - 2115, Saint Louis, Missouri

Local Institution - 2122, New Brunswick, New Jersey

Local Institution - 2117, New York, New York

Local Institution - 2102, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Local Institution - 2144, Goldsboro, North Carolina

Local Institution - 2112, Canton, Ohio

Local Institution - 2143, Cincinnati, Ohio

Local Institution - 2109, Cleveland, Ohio

Local Institution - 2123, Columbus, Ohio

Local Institution - 2119, Toledo, Ohio

Local Institution - 2108, Philadelphia, Pennsylvania

Local Institution - 2148, Memphis, Tennessee

Local Institution - 2130, Dallas, Texas

Local Institution - 2127, Houston, Texas

Local Institution - 2138, Houston, Texas

Local Institution - 2146, Kingwood, Texas

Local Institution - 2137, Fairfax, Virginia

Local Institution - 2107, Seattle, Washington

Local Institution - 2141, Tacoma, Washington

Local Institution - 2145, Appleton, Wisconsin

Local Institution - 6102, Camperdown, New South Wales

Local Institution - 6103, Adelaide, South Australia

Local Institution - 6101, Melbourne, Victoria

Local Institution - 3301, East Melbourne, Not set

Local Institution - 4802, Antwerp, Not set

Local Institution - 4801, Leuven, Not set

Local Institution - 2202, Edmonton, Alberta

Local Institution - 2205, Vancouver, British Columbia

Local Institution - 2201, Toronto, Ontario

Local Institution - 6503, Toronto, Ontario

Local Institution - 2203, Ontario, Not set

Local Institution - 2204, Ottawa, Not set

Local Institution - 6702, Beijing, Beijing

Beijing Cancer hospital, Beijing, Beijing

Daping Hospital, the Third Affiliated Hospital of Third Military Medical University /Cancer Center, Daping, Chongqing

Local Institution - 6719, Fuzhou, Fujian

The First Affiliated hospital of Xiamen University-oncology, Xiamen, Fujian

Guangdong Provincial People'S Hospital, Guangzhou, Guangdong

Local Institution - 6733, Guangzhou, Guangdong

Local Institution - 6505, Shenzhen, Guangdong

The Affiliated Tumor Hospital of Harbin Medical University, Harbin, Heilongjiang

Local Institution - 6504, Shatin, Hong Kong

Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology/Cancer Center Department, Wuhan, Hubei

Local Institution - 6705, Changsha, Hunan

Hunan Cancer Hospital-thoracic oncology II, Changsha, Hunan

Local Institution - 6748, Nanjing, Jiangsu

XuZhou Central Hospital/Oncology Department, Xuzhou City, Jiangsu

Jilin Cancer Hospital/Medical Oncology Department, Changchun, Jilin

The first hospital of Jilin university-Oncology Department, Changchun, Jilin

Liaoning Cancer Hospital, Shenyang, Liaoning

Tangdu Hospital, Xi'an, Shan3xi

Shanxi Bethune Hospital, Taiyuan, Shanxi

Sichuan Cancer Hospital/Medical Oncology Department, Chengdu City, Sichuan

The First Hospital Affiliated To AMU - Southwest Hospital, Chongqing, Sichuan

Local Institution - 6725, Hangzhou, Zhejiang

Zhejiang Cancer Hospital-Oncology, Hangzhou, Zhejiang

The Third Xiangya Hospital of Central South University/Department of Respiratory and Critical Care Medicine, Changsha, Not set

West China Hospital Sichuan University/Lung cancer center, Chengdu, Not set

The First Affiliated Hospital - Zhejiang University School of Medicine, Hangzhou, Not set

Anhui Provincial Hospital, Hefei, Not set

Shanghai Chest Hospital, Shanghai, Not set

Weifang People's Hospital/Medical Oncology Department, Weifang City, Not set

Henan Cancer Hospital/The 1st pneumology department, Zhengzhou, Not set

Local Institution - 4901, Copenhagen, Not set

Local Institution - 4201, Marseille, Bouches-du-Rhône

Local Institution - 4207, Brest, Not set

Local Institution - 4204, Dijon Cedex, Not set

Local Institution - 4206, Grenoble Cedex 9, Not set

Centre Antoine-Lacassagne, Nice, Not set

Chu Poitiers, Poitiers, Not set

Local Institution - 4203, St Mande, Not set

Institute Gustave Roussy, Villejuif, Not set

Local Institution - 4704, Berlin, Not set

Local Institution - 4703, Dresden, Not set

Local Institution - 4702, Heidelberg, Not set

Local Institution - 4701, Koln, Not set

Local Institution - 6502, Hong Kong, Not set

Local Institution - 6501, Hong Kong, Not set

Local Institution - 5101, Budapest, Not set

Local Institution - 5103, Budapest, Not set

Local Institution - 4301, Milano, MI

Local Institution - 4306, Milano, Not set

Local Institution - 4307, Palermo, Not set

Local Institution - 4303, Pordenone, Not set

Local Institution - 4304, Ravenna, Not set

Local Institution - 4305, Reggio Emilia, Not set

Local Institution - 4308, Roma, Not set

Local Institution - 4302, Terni, Not set

Ehime University Hospital, Toon, Ehime

Hokkaido University Hospital, Sapporo-shi, Hokkaido

Kanagawa cancer center, Yokohama, Kanagawa

Osaka City General Hospital, Osaka-shi, Osaka

National Cancer Center Hospital., Chuo-ku, Tokyo

Tottori University Hospital, Yonago, Tottori

National Cancer Center Hospital East, Kashiwa, Not set

Nagoya University Hospital, Nagoya-shi, Not set

Osaka International Cancer institute, Osaka, Not set

Local Institution - 3003, Seoul, Gangnam-gu

Local Institution - 6308, Hwasun-eup, Hwasun-gun, Jeonnam

Yonsei University Health System, Seoul, Seodaemun-gu

Local Institution - 3002, Seoul, Seoul Teugbyeolsi

Local Institution - 6301, Seoul, Seoul-teukbyeolsi [Seoul]

Local Institution - 6303, Seoul, Seoul-teukbyeolsi [Seoul]

Local Institution - 6306, Cheongju-si, Not set

Seoul National University Hospital, Seoul, Not set

Local Institution - 6302, Seoul, Not set

Local Institution - 6307, Seoul, Not set

Local Institution - 6305, Seoul, Not set

Local Institution - 6304, Seoul, Not set

Local Institution - 4502, Amsterdam, Not set

Local Institution - 4501, Groningen, Not set

Ośrodek Badań Klinicznych Wczesnych Faz, Uniwersyteckie Centrum Kliniczne, Gdańsk, Not set

Local Institution - 4604, Lublin, Not set

Local Institution - 4605, Poznań, Not set

Local Institution - 4603, Szczecin, Not set

Local Institution - 4602, Warszawa, Not set

Local Institution - 6401, Singapore, Not set

Local Institution - 6402, Singapore, Not set

Local Institution - 4102, Barcelona, Not set

Local Institution - 4101, Barcelona, Not set

Local Institution - 4106, Madrid, Not set

Local Institution - 4104, Madrid, Not set

Local Institution - 4103, Madrid, Not set

Local Institution - 4105, Madrid, Not set

Clinica Universidad de Navarra, Pamplona, Not set

Instituto Valenciano de Oncología (IVO) - Unidad de Investigación Clínica FINCIVO, Valencia, Not set

Local Institution - 6201, Taiepi, Not set

Local Institution - 6203, Tainan, Not set

Local Institution - 6202, Taipei, Not set

Local Institution - 4401, London, Not set

Local Institution - 4402, London, Not set

Local Institution - 4404, London, Not set

Local Institution - 4403, Manchester, Not set

Local Institution - 4405, Sutton, Not set

Conditions: Locally Advanced Solid Tumors, Metastatic Solid Tumors

Learn More ›

Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal Treatment

NCT06522438

Recruiting

This parallel-group, pilot study will test the hypothesis that the adjunctive use of a thermosensitive gel containing Hyaluronic Acid (HA) and Octenidine to non-surgical periodontal treatment (NSPT) will be able to modulate the early wound healing events. This will be assessed through the expression of specific gingival crevicular fluid markers, as well as by changes in gingival blood flow (assessed by laser speckle contrast imaging), bacterial load, soft tissues contour, clinical parameters and... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: Centre for Oral Clinical Research (COCR), London, Not set +1 locations

Conditions: Periodontitis, Wound Heal, Periodontal Pocket, Periodontal Inflammation, Periodontal Attachment Loss

Learn More ›

European Aortic Data Collection Project

NCT05896397

Recruiting

The purpose of this study is to evaluate the safety and performance of Cook's various Custom-Made Stent-graft Devices (CMD) used for endovascular treatment of the aorta and related diseases by collecting information on the real-world use of the devices. The study results will be used to support the continuation of the CMDs on the market. In addition, the study will support the manufacturers obligation for post market product surveillance as well as Cook's technology development.

Gender:

ALL

Ages:

All

Trial Updated:

07/07/2025

Locations: Aarhus University Hospital, Aarhus, Not set +17 locations

Conditions: Complex Abdominal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Aortic Arch Aneurysm, Chronic Aortic Dissection

Learn More ›

A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

NCT05797610

Recruiting

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of sefaxersen (RO7434656), a novel Antisense Oligonucleotide (ASO) therapy in participants with primary IgA nephropathy (IgAN) who are at high risk of progressive kidney disease despite optimized supportive care.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: UAB Nephrology Research Clinic, Birmingham, Alabama +182 locations

UAB Nephrology Research Clinic, Birmingham, Alabama

Sunrise Medical Management LLC, Surprise, Arizona

Tucson Neuroscience Research - M3 WR, Tucson, Arizona

Southern California Medical Research Center, La Palma, California

Academic Medical Research Institute - Los Angeles, Los Angeles, California

UCLA University of California Los Angeles, Los Angeles, California

North America Research Institute-San Dimas, San Dimas, California

Hope Clinic & Research Center, Hialeah, Florida

LCC Medical Research - Miami - ClinEdge - PPDS, Miami, Florida

L&C Professional Medical Research Institute, W. Miami, Florida

Cowry Medical Group LLC, Acworth, Georgia

Care Institute Idaho Kidney Institute, Chubbuck, Idaho

Care Institute Idaho Kidney Institute, Idaho Falls, Idaho

Nephrology Associates of Northern Illinois, Hinsdale, Illinois

University of Iowa, Iowa City, Iowa

Massachussets General Hospital, Boston, Massachusetts

University of Mississippi Medical Center, Jackson, Mississippi

Sierra Nevada Nephrology Consultants, Reno, Nevada

NYU Langone Nephrology Associates - Mineola, Mineola, New York

North Carolina Nephrology, PA, Raleigh, North Carolina

Ohio State University Wexner Medical Center - Outpatient Care East, Columbus, Ohio

Kidney and Hypertension Center, Roseburg, Oregon

Global Medical Research - M3 WR, Dallas, Texas

Texas Kidney Institute - Dallas, Dallas, Texas

Pioneer Research Solutions, Houston, Texas

Prolato Clinical Research Center, Houston, Texas

R & H Clinical Research, Katy, Texas

Revival Research Corporation - Sherman - ClinEdge - PPDS, Sherman, Texas

Utah Kidney Research Institute, Salt Lake City, Utah

Nephrology Associates of Northern Virginia Inc, Fairfax, Virginia

Virginia Commonwealth University, Richmond, Virginia

Milwaukee Nephrologists, Sc, Wauwatosa, Wisconsin

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada, Ciudad Autonoma Buenos Aires, Not set

Consultorios Médicos Dr. Doreski, Ciudad Autonoma Buenos Aires, Not set

Sanatorio Mayo Privado, Cordoba, Not set

Sanatorio Allende, Cordoba, Not set

Instituto Medico de la Fundacion Estudios Clinicos, Rosario, Not set

Nepean Hospital, Kingswood, New South Wales

St George Hospital, Kogarah, New South Wales

Liverpool Hospital, Liverpool, New South Wales

Princess Alexandra Hospital, Woolloongabba, Queensland

Royal Adelaide Hospital, Adelaide, South Australia

Royal Melbourne Hospital, Parkville, Victoria

Sunshine Hospital, St Albans, Victoria

Santa Casa de Misericordia de Belo Horizonte - PPDS, Belo Horizonte, Minas Gerais

Freire Pesquisa Clinica, Belo Horizonte, Minas Gerais

Hospital de Clinicas de Porto Alegre HCPA PPDS, Porto Alegre, Rio Grande Do Sul

Centro de Pesquisa Clinica da Fundação Pró Rim, Joinville, Santa Catarina

Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, São Paulo

Hospital Do Rim E Hipertensao Fundacao Oswaldo Ramos, Sao Paulo, São Paulo

Instituto D?Or Pesquisa e Ensino - Hospital Gloria D?Or, Rio de Janeiro, Not set

Vancouver General Hospital, Vancouver, British Columbia

Cape Breton Regional Hospital, Sydney, Nova Scotia

London Health Sciences Centre · Victoria Hospital, London, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

Montreal General Hospital, Montreal, Quebec

Centre Hospitalier Universitaire de Quebec, Quebec, Not set

Beijing Friendship Hospital, Capital Medical University - PPDS, Beijing, Beijing

Peking University First Hospital, Beijing City, Not set

Peking University People's Hospital, Beijing, Not set

Changzhou First People's Hospital, Changzhou, Not set

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu City, Not set

Guangdong Provincial People's Hospital, Guangzhou City, Not set

Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou City, Not set

Zhejiang Provincial People?s Hospital, Hangzhou, Not set

The Second Affiliated Hospital of Nanchang University, Nanchang City, Not set

The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Not set

Ningbo No.2 Hospital, Ningbo City, Not set

Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai City, Not set

Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, Shanghai, Not set

Shenzhen People's Hospital, Shenzhen City, Not set

The University of Hong Kong - Shenzhen Hospital, Shenzhen City, Not set

The Second Affiliated Hospital of Soochow University, Suzhou, Not set

Renmin Hospital of Wuhan University, Wuhan, Not set

The First Affiliated Hospital of Xian Jiao Tong University, Xi'an City, Not set

General Hospital of Ningxia Medical University, Yinchuan, Not set

Affiliated Hospital of Jiangsu University, Zhenjiang, Not set

Fakultni nemocnice Hradec Kralove, Hradec Kralove, Not set

Vseobecna fakultni nemocnice v Praze, Praha 2, Not set

Centre Hospitalier, Annonay, Not set

CHU Boulogne sur Mer, Boulogne Sur Mer, Not set

Hopital Henri Mondor, Creteil, Not set

Hopital Tenon, Paris, Not set

Hopital Bichat - Claude Bernard AP-HP, Paris, Not set

Hôpital de Rangueil, Toulouse, Not set

Universitatsklinikum der RWTH Aachen, Aachen, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Klinikum Koln-Merheim, Köln, Not set

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Not set

University General Hospital of Heraklion, Heraklion, Not set

Venizeleio General Hospital of Heraklion, Irakleio Kritis, Not set

University General Hospital of Patras, Patra, Not set

Ippokratio General Hospital of Thessaloniki, Thessaloniki, Not set

Queen Mary Hospital, Hong Kong, Not set

Azienda Ospedaliera Universitaria Federico II, Napoli, Campania

Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi-Via Massarenti, Bologna, Emilia-Romagna

Fondazione Policlinico Universitario A Gemelli, Roma, Lazio

Ospedale Policlinico San Martino, Genova, Liguria

IRCCS Pavia - Istituti Clinici Scientifici Maugeri Spa ? Società Benefit, Pavia, Lombardia

Ospedale San Giovanni Bosco, Torino, Piemonte

Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Puglia

Fujita Health University Hospital, Aichi, Not set

Hirosaki University Hospital, Aomori, Not set

Juntendo University Urayasu Hospital, Chiba, Not set

University of Yamanashi Hospital, Chuo, Not set

Matsuyama Red Cross Hospital, Ehime, Not set

Japanese Red Cross Fukuoka Hospital, Fukuoka, Not set

Hiroshima University Hospital, Hiroshima, Not set

Hokkaido University Hospital, Hokkaido, Not set

Tokyo Medical University Ibaraki Medical Center, Inashiki-Gun, Not set

Kanazawa Medical University Hospital, Ishikawa, Not set

Iwate Medical University Hospital, Iwate, Not set

Nara Medical University Hospital, Kashihara, Not set

Kumamoto University Hospital, Kumamoto, Not set

Tohoku University Hospital, Miyagi, Not set

Kyoto City Hospital, Nakagyo-ku, Not set

Nara Prefecture General Medical Center, Nara, Not set

Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Not set

Okayama University Hospital, Okayama-Shi Kita-Ku, Not set

National Hospital Organization Okayama Medical Center, Okayama, Not set

University of the Ryukyus Hospital, Okinawa, Not set

Saitama Medical University Hospital, Saitama, Not set

Osaka University Hospital, Suita, Not set

Jichi Medical University Hospital, Tochigi, Not set

Tokushima University Hospital, Tokushima, Not set

The Jikei University Hospital, Tokyo, Not set

Juntendo University Hospital, Tokyo, Not set

Tokyo Women's Medical University Hospital, Tokyo, Not set

Juntendo University Nerima Hospital, department of renal and hypertension, Tokyo, Not set

University of Tsukuba Hospital, Tsukuba, Not set

Yamaguchi University Hospital, Ube, Not set

Hallym University Sacred Heart Hospital, Anyang-si, Not set

Soon Chun Hyang University Hospital Bucheon, Bucheon-si,, Not set

Chungbuk National University Hospital, Cheongju si, Not set

Ajou University Hospital, Gyeonggi-do, Not set

CHA Bundang Medical Center, CHA University, Seongnam-si, Not set

Seoul National University Bundang Hospital, Seongnam-si, Not set

Seoul National University Hospital, Seoul, Not set

Konkuk University Medical Center, Seoul, Not set

Gangdong Kyung Hee University Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

SMG-SNU Boramae Medical Center, Seoul, Not set

Hospital Kuala Lumpur, Kuala Lumpur, FED. Territory OF Kuala Lumpur

University Malaya Medical Centre, Kuala Lumpur, FED. Territory OF Kuala Lumpur

Hospital Tengku Ampuan Afzan, Kuantan, Pahang

Hospital Seri Manjung, Seri Manjong, Pahang

Taiping Hospital, Taiping, Perak

Hospital Sibu, Sibu, Sarawak

Hospital Ampang, Ampang, Not set

Miri Hospital, Miri, Not set

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Barrio Belisario Domínguez Secc XVI, Mexico CITY (federal District)

Centro de Investigacion Clinica Chapultepec S. A. de C. V., Morelia, Michoacan

Instituto Mexicano de Trasplantes, Cuernavaca, Morelos

Christus Latam Hub Center Of Excellence & Innovation, Monterrey, Nuevo LEON

Centenario Hospital Miguel Hidalgo, Aguascalientes, Not set

SCM Clinic - Prywatny Szpital Specjalistyczny, Kraków, Not set

SPZOZ Centralny Szpital Klin, Lodz, Not set

Szpital Kliniczny im. H.Swiecickiego UM w Poznaniu, Pozna?, Not set

Szpital Kliniczny Dzieciatka Jezus, Warszawa, Not set

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu, Wroc?aw, Not set

National University Hospital, Singapore, Not set

Singapore General Hospital, Singapore, Not set

Tan Tock Seng Hospital, Singapore, Not set

Changi General Hospital, Singapore, Not set

Hospital Universitari Arnau de Vilanova, Lleida, Lerida

Hospital Universitario Vall d'Hebron - PPDS, Barcelona, Not set

Hospital Ribera Polusa, Lugo, Not set

Hospital Universitario 12 De Octubre, Madrid, Not set

Hospital Universitario La Paz - PPDS, Madrid, Not set

Hospital Universitario Virgen del Rocio - PPDS, Sevilla, Not set

Changhua Christian Hospital, Changhua, Not set

Chang Gung Medical Foundation, Kaohsiung, Not set

China Medical University Hospital, Taichung, Not set

Far Eastern Memorial Hospital, Taipei, Not set

Chang Gung Memorial Hospital, Linkou, Taoyuan City, Not set

Taichung Veterans General Hospital, Xitun Dist., Not set

Mackay Memorial Hospital-Taipei branch, Zhongshan Dist., Not set

Addenbrookes Hospital, Cambridge, Not set

Leicester General Hospital, Leicester, Not set

Guys and St Thomas Hospital, London, Not set

Kings College Hospital, London, Not set

Churchill Hospital, Oxford, Not set

Salford Royal Hospital, Salford, Not set

Conditions: Primary IgA Nephropathy

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Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

NCT06127407

Recruiting

Study CL3-95031-007 (CHONQUER) is a Phase 3, international, multicenter, double-blind, randomized, placebo-controlled study of orally administered ivosidenib. Participants are required to have a histopathological diagnosis consistent with isocitrate dehydrogenase-1 (IDH1) gene-mutated, locally advanced or metastatic conventional chondrosarcoma Grades 1, 2, or 3 and not eligible for curative resection. IDH1 mutant status will be determined during pre-screening/screening phase. Participant must ha... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/07/2025

Locations: Usc Norris Comprehensive Cancer Center, Los Angeles, California +75 locations

Usc Norris Comprehensive Cancer Center, Los Angeles, California

Sarcoma Oncology Research Center, Santa Monica, California

University of Colorado Cancer Center, Aurora, Colorado

Yale Cancer Center, New Haven, Connecticut

Mayo Clinic - Jacksonville, Fl, Jacksonville, Florida

University of Miami, Miami, Florida

Emory Winship Cancer Institute, Atlanta, Georgia

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois

University of Iowa Hospitals & Clinics- Holden Comprehensive Cancer Center, Iowa City, Iowa

Dana-Farber Cancer Institute, Boston, Massachusetts

Mayo Clinic - Rochester, Mn, Rochester, Minnesota

The Washington University, Saint Louis, Missouri

Nebraska Methodist Hospital, Omaha, Nebraska

Memorial Sloan Kettering Cancer Center, New York, New York

Duke University, Durham, North Carolina

Cleveland Clinic, Cleveland, Ohio

The Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Oregon Health & Science University Knight Cancer Institute, Portland, Oregon

University of Pittsburgh Medical Center-Hillman Cancer Center, Pittsburgh, Pennsylvania

Vanderbilt University Medical Center, Nashville, Tennessee

The Univeristy of Texas Md Anderson Cancer Center, Houston, Texas

Flinders Medical Centre, Bedford Park, Not set

Chris O'Brien Lifehouse, Camperdown, Not set

St Vincent'S Hospital Melbourne, Fitzroy, Not set

Sir Charles Gairdner Hospital, Nedlands, Not set

Princess Alexandra Hospital, Woolloongabba, Not set

Hospital de Amor - Barretos, Barretos, Not set

Hospital Das Clínicas Da Ufmg, Belo Horizonte, Not set

CIONC, Curitiba, Not set

Cepon - Centro de Pesquisas Oncologicas, Florianópolis, Not set

Fundação Amaral Carvalho - Jaú/ Sp, Jaú, Not set

Instituto Nacional Do Câncer - Inca, Rio De Janeiro, Not set

Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo, Not set

Impar Serviços Hospitalares S.A. - Hospital Nove de Julho, São Paulo, Not set

Hospital A C Camargo, São Paulo, Not set

Hospital Albert Einstein, São Paulo, Not set

University Health Network, Toronto, Ontario

Muhc Glen Site, Montréal, Quebec

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei

Shanghai General Hospital, Shanghai, Shanghai

West China Hopital of Sichuan University, Chengdu, Sichuan

The Second Affiliated Hospital Zhejiang University School of Medical, Hangzhou, Zhejiang

Helios Klinikum Bad Saarow, Bad Saarow, Not set

Charite Universitatsmedizin, Berlin, Not set

Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Not set

Universitätsmedizin Mannheim (Umm), Mannheim, Not set

Lmu Klinikum, Muenchen, Not set

Aou Policlinico Paolo Giaccone, Palermo, Not set

Ospedale Santo Stefano, Prato, Not set

Policlinico Universitario Campus Biomedico, Roma, Not set

Istituti Fisioterapici Ospitalieri (Ifo) - Istituto Nazionale Tumori Regina Elena (Ire), Roma, Not set

Hokkaido Cancer Center, Sapporo, Hokkaido

Kanazawa University Hospital, Kanazawa, Ishikawa

Nagoya University Hospital, Showa-ku, Nagoya-shi, Aichi

Oita University Hospital, Yufu-Shi, Oita

Osaka International Cancer Institute, Chuo Ku, Osaka-shi, Osaka

National Cancer Center Hospital, Chuo-ku, Tokyo, Not set

Kyushu University Hospital, Higashi, Not set

Cancer Institute Hospital of Jfcr, Koto-Ku, Tokyo, Not set

Okayama University Hospital, Okayama, Not set

Universitair Medisch Centrum Groningen (Umcg), Groningen, Not set

Leids Universitair Medisch Centrum, Leiden, Not set

Radboud Umc, Nijmegen, Not set

Hospital Universitario Valle de Hebrón - Vhio, Barcelona, Not set

Hospital de La Santa Creu I Sant Pau, Barcelona, Not set

Hospital de Bellvitge - Ico, L'Hospitalet De Llobregat, Not set

Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Y Politecnico La Fe, Valencia, Not set

National Taiwan University Hospital, Taipei, Not set

Western General Hospital, Edinburgh, Not set

Royal Marsden Hospital, London, Not set

UCLH, London, Not set

Christie Hospital, Manchester, Not set

Churchill Hospital, Oxford, Not set

Conditions: Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

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Parasitic Ulcer Treatment Trial

NCT06213649

Recruiting

The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis (AK) will improve vision. Patients presenting to all enrollment centers with evidence of acanthamoeba keratitis will be eligible for the trial if there is evidence of ocular inflammation after 4 weeks of anti-amoebic therapy. Those who agree to participate will be random... Read More

Gender:

ALL

Ages:

8 years and above

Trial Updated:

07/07/2025

Locations: University of California, Los Angeles, Los Angeles, California +13 locations

Conditions: Acanthamoeba Keratitis

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A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

NCT02332668

Recruiting

Researchers are looking for new ways to treat children with different types of melanoma (skin cancer), solid tumors, and lymphomas (blood cancers) that are any of these: * Advanced, which means cancer spread in the body or cannot be removed with surgery * Relapsed, which means cancer has come back after it had responded to previous treatment (responded means it stopped growing, gets smaller, or disappeared) * Refractory, which means cancer did not respond to previous treatment Pembrolizumab is... Read More

Gender:

ALL

Ages:

Between 6 months and 17 years

Trial Updated:

07/04/2025

Locations: Call for Information (Investigational Site 0019), Aurora, Colorado +16 locations

Conditions: Melanoma, Lymphoma, Solid Tumor, Classical Hodgkin Lymphoma, Microsatellite-instability-high Solid Tumor

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A Phase 1 Study to Assess STP938 as a Monotherapy in Adults With High Risk Essential Thrombocythaemia

NCT06786234

Recruiting

The goal of this clinical trial is to learn if the drug STP938 works to treat adults with high risk essential thrombocythaemia (ET) who are resistant to, or intolerant of, hydroxycarbamide (also known as hydroxyurea) therapy. The trial will also learn about the safety of STP938. The main questions the trial aims to answer are: * Does STP938 control platelet counts * Does STP938 control platelet counts without inducing unwanted side effects Participants will: * Take STP938 every day for up to... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/04/2025

Locations: CHU Brest, Brest, Not set +11 locations

Conditions: Essential Thrombocythaemia

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Post-market Clinical Follow-up (PMCF) Study of the Infinity-Lock Button System for Acromioclavicular Joint Stabilisation

NCT05397210

Recruiting

This is a Post-market Clinical Follow-up Study. It will verify the long-term safety and performance of the Infinity-Lock Button System (ILBS) when used for acute and chronic dislocations of the Acromioclavicular Joint and used as described by the manufacturer's instructions.

Gender:

ALL

Ages:

16 years and above

Trial Updated:

07/04/2025

Locations: Leeds Teaching Hospitals NHS Trust, Leeds, West Yorkshire +5 locations

Conditions: Acromioclavicular; Dislocation

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