A Rhinovirus Challenge Study to Investigate Exacerbations and Immune Responses in Bronchiectasis
NCT06931002
Recruiting
The goal of this study is to determine if viral infection with the common cold leads to an exacerbation in participants with bronchiectasis. The investigators will compare the participants with bronchiectasis to a group of healthy participants. The main questions it aims to answer are: * Does viral infection with the common cold lead to an exacerbation in bronchiectasis? * Does the immune response differ to that of a healthy participant? Participants will attend for a screening visit to see if... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/04/2025
Locations: St Mary's Hospital - Imperial Clinical Respiratory Research Unit (ICRRU), London, Not set
Conditions: Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation, Bronchiectasis With Chronic Infection With Pseudomonas Aeruginosa, Viral Infection, Rhinovirus Infection
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A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
NCT05711394
Recruiting
A migraine is a moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms. A number of treatments are available for adults with migraine but there are limited approved treatments available for pediatric participants. The main goal of the study is to evaluate the safety and efficacy (how well treatment works) of a low-dose and high-dose of atogepant in pediatric par... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
07/04/2025
Locations: Rehabilitation & Neurological Services /ID# 248517, Huntsville, Alabama +93 locations
Conditions: Episodic Migraine
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The Efficacy and Safety of Rilzabrutinib in Patients Aged 10 to 65 Years With Sickle-cell Disease
NCT06975865
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, group-sequential study (Part A), followed by an open-label LTE period (Part B) to investigate the efficacy, and safety of rilzabrutinib in participants with sickle-cell disease (SCD). Study details include: * Study duration: a 52-week double-blind period (Part A), followed by an open-label LTE period (Part B). Double-blind period has two parts, 50% (adult only) until the interim analysis (a proof-concept part... Read More
Gender:
ALL
Ages:
Between 10 years and 65 years
Trial Updated:
07/04/2025
Locations: Bioresearch Partners- Site Number : 8400005, Hialeah, Florida +2 locations
Conditions: Sickle Cell Disease
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A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)
NCT02332668
Recruiting
Researchers are looking for new ways to treat children with different types of melanoma (skin cancer), solid tumors, and lymphomas (blood cancers) that are any of these: * Advanced, which means cancer spread in the body or cannot be removed with surgery * Relapsed, which means cancer has come back after it had responded to previous treatment (responded means it stopped growing, gets smaller, or disappeared) * Refractory, which means cancer did not respond to previous treatment Pembrolizumab is... Read More
Gender:
ALL
Ages:
Between 6 months and 17 years
Trial Updated:
07/04/2025
Locations: Call for Information (Investigational Site 0019), Aurora, Colorado +16 locations
Conditions: Melanoma, Lymphoma, Solid Tumor, Classical Hodgkin Lymphoma, Microsatellite-instability-high Solid Tumor
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A Phase 1 Study to Assess STP938 as a Monotherapy in Adults With High Risk Essential Thrombocythaemia
NCT06786234
Recruiting
The goal of this clinical trial is to learn if the drug STP938 works to treat adults with high risk essential thrombocythaemia (ET) who are resistant to, or intolerant of, hydroxycarbamide (also known as hydroxyurea) therapy. The trial will also learn about the safety of STP938. The main questions the trial aims to answer are: * Does STP938 control platelet counts * Does STP938 control platelet counts without inducing unwanted side effects Participants will: * Take STP938 every day for up to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/04/2025
Locations: CHU Brest, Brest, Not set +11 locations
Conditions: Essential Thrombocythaemia
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Drug-induced Liver Injury: Itching Study
NCT06446609
Recruiting
Idiosyncratic drug-induced liver injury (DILI) is an unpredictable adverse hepatic reaction to a medication used in its therapeutic dose. DILI is the second most common cause of itching in adult Hepatology after biliary obstruction. In particular cholestatic or mixed pattern types of DILI (in which bile flow from the liver is impaired) are associated with long-lasting effects as well as reduced quality of life. There is therefore an urgent need to determine the incidence and natural history of i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Nottingham University Hospitals NHS Trust, Nottingham, Not set
Conditions: Drug Induced Liver Injury, Pruritus
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A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
NCT06318169
Recruiting
The study will assess the efficacy and safety of 2 dose regimens of pegozafermin for the treatment of liver fibrosis stage 2 or 3 in adult participants with MASH (previously known as nonalcoholic steatohepatitis \[NASH\]).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/03/2025
Locations: 89bio Clinical Study Site, Birmingham, Alabama +238 locations
Conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis
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Pelvic Floor Exercises for Suboptimal Anorectal Manometry
NCT07062731
Recruiting
Currently, guidelines from the Royal College of Obstetricians and Gynaecologists stipulate that all women who have sustained an obstetric anal sphincter injury in a previous pregnancy and who are symptomatic or have abnormal endoanal ultrasonography and/ or manometry should be counselled regarding the option of an elective Caesarean section. An abnormal endoanal ultrasonography is currently considered to be a defect of the external anal sphincter (EAS) of more than 30 degrees while an abnormal a... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Kings College Hospital, London, Not set
Conditions: Obstetric Anal Sphincter Injury
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High Dose Steroids in Children With Stroke
NCT04873583
Recruiting
This clinical trial deals with focal cerebral arteriopathy and childhood stroke, a rare but devastating condition. Focal cerebral arteriopathy (FCA) is an inflammatory vessel wall disease provoked by infection and there is increasing evidence that inflammatory processes play a crucial role in childhood stroke, influencing the outcome of the disease. Analysis of existing data suggests that outcomes are improved and that there is less stroke recurrence in children treated with steroids to reduce... Read More
Gender:
ALL
Ages:
Between 6 months and 17 years
Trial Updated:
07/03/2025
Locations: Sydney Childrens Hospital Randwick, Randwick, New South Wales +33 locations
Conditions: Paediatric Stroke
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A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia
NCT05952037
Recruiting
This study will evaluate the safety and efficacy of the BCL2 inhibitor sonrotoclax (BGB-11417) in participants with relapsed/refractory Waldenström's Macroglobulinemia (R/R WM) and in combination with zanubrutinib in adult participants with previously untreated WM.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: City of Hope National Medical Center, Duarte, California +71 locations
Conditions: Waldenstrom Macroglobulinemia, Waldenstrom's Macroglobulinemia Recurrent, Waldenstrom's Macroglobulinemia Refractory
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Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
NCT07048405
Recruiting
This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health. While intermittent cold exposure has been shown to increase BAT activity and mass, as measured by fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography/computed tomography (PET/CT) scans, the molecular adaptations within BAT and other thermogenic tissues including skele... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/03/2025
Locations: Royal Infirmary of Edinburgh, Edinburgh, Not set
Conditions: Brown Adipose Tissue, Cold Exposure, 18F-FDG PET/CT
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Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial
NCT05072314
Recruiting
The LOLIPOP Trial is a large (n=4,300 patients) pragmatic, international, multicentre, prospective, randomised, double blind, placebo-controlled, parallel assessment, safety and effectiveness superiority study.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Blacktown Mount Druitt Hospital, Mount Druitt, New South Wales +38 locations
Conditions: Breast Cancer, Breast Cancer Female, Breast Conserving Surgery, Mastectomy
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