Palliative Care and Oncology Survey on Terminology
NCT05871996
Recruiting
The term '"cancer survivors" is widely used but has different definitions. One definition describes "cancer survivors" as individuals from the time of diagnosis throughout their lives, which includes people living with cancer and people free of cancer. The views of some groups included in this definition of "cancer survivors" have rarely been assessed, including those with cancer on anticancer treatment and those known to palliative care. How they view these terms could have important implicatio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: St Vincent's University Hospital, Dublin, County Dublin +2 locations
Conditions: Cancer
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The "MyoThrombus" Study
NCT04829825
Recruiting
Left ventricular thrombus is a recognised complication of acute myocardial infarction, associated with stroke, recurrent myocardial infarction and adverse cardiac remodelling. The prevention, treatment and resolution of thrombus is hampered by a lack of understanding of its initiation, propagation and dissolution. Advanced non-invasive imaging holds major promise in improving our understanding of the incidence and the natural history of left ventricular thrombus as well as providing potential bi... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
06/23/2025
Locations: Royal Infirmary Edinburgh, Edinburgh, Not set
Conditions: Left Ventricular Thrombus, Thrombosis, STEMI, Stroke
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Fibrosis in Chronic and Delayed Myocardial Infarction
NCT05756608
Recruiting
In this study the investigators aim to examine the role that fibrosis plays in heart conditions such as aortic stenosis , chemotherapy-induced cardiotoxicity and carcinoid syndrome . Fibrosis is a common final result following any injury to the heart muscle and the investigators aim to identify this process early and in its active state. This will be examined by using a radiotracer 68Ga-FAPI or 18F-AlF-FAPI and PET-MRI or PET-CT.
Gender:
ALL
Ages:
Between 40 years and 90 years
Trial Updated:
06/23/2025
Locations: University of Edinburgh, Edinburgh, Scotland
Conditions: Aortic Stenosis, Chemotherapy Induced Systolic Dysfunction, Carcinoid Syndrome
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A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)
NCT02991469
Recruiting
Primary Objective: To describe the pharmacokinetic (PK) profile of sarilumab in patients aged 1-17 years with Systemic Juvenile Idiopathic Arthritis (sJIA) in order to identify the dose and regimen for adequate treatment of this population. Secondary Objective: To describe the pharmacodynamics (PD) profile, the efficacy, and the long term safety of sarilumab in patients with sJIA.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
06/23/2025
Locations: Investigational Site Number : 0320004, San Miguel de Tucumán, Tucumán +26 locations
Conditions: Juvenile Idiopathic Arthritis
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A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies.
NCT06916806
Recruiting
The purpose of this study is to measure the safety, tolerability, PK, and PD of AZD5492 administered subcutaneously in adult participants with SLE or IIM. Study details include: • The study duration will be a minimum of 180 days in addition to the screening period. Additional follow-up visits may be required up to 12 months from study start. * Depending on the study part they are assigned to, participants will be administered AZD5492 once (Part 1) or twice (Part 2). * Study visits will occur... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/23/2025
Locations: Research Site, Anniston, Alabama +28 locations
Conditions: Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
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Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)
NCT06486441
Recruiting
The goal of this clinical study is to find out how the study drug, sacituzumab govitecan (SG) works in participants with endometrial cancer who have received prior treatment with platinum-based chemotherapy and immunotherapy, versus the treatment of physician's choice (TPC). The primary objectives of this study are to evaluate the effect of SG compared to TPC on progression-free survival (PFS) as assessed by blinded independent central review (BICR) and overall survival (OS).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +170 locations
Conditions: Endometrial Cancer
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Investigation of the Acute Effects of Nepalese Pepper Extract (Zanthoxylum Armatum DC) on Cognitive Function, Mood and Gaming Performance in Young, Healthy, Competitive Gamers
NCT07047105
Recruiting
The goal of this clinical trial is to learn if a Nepalese Pepper Extract (Zanthoxlum Armatum, ZA) supplement can improve cognitive performance and mental abilities in competitive gamers aged 16 to 34. The main questions it aims to answer are: 1. Does ZA supplement improve cognitive abilities like attention, memory, and decision-making? 2. What is the most effective dose of ZA supplement (300mg vs 150mg)? 3. How do the effects of ZA supplement compare to caffeine? Researchers will compare four... Read More
Gender:
ALL
Ages:
Between 16 years and 34 years
Trial Updated:
06/23/2025
Locations: Northumbria University - Brain Performance and Nutrition Research Centre, Newcastle upon Tyne, Not set
Conditions: Cognition, Mood, Gaming Performance, Fatigue
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Diagnosing Corneal Infection
NCT04230811
Recruiting
Microbial keratitis is a common and serious eye disease in Edinburgh. Prompt treatment with antibiotics can prevent sight loss, and identification of the micro-organism and its antibiotic sensitivities are key to appropriate management. Standard practice of collecting infected material from the cornea using a blade can be distressing and time-consuming. Corneal impression membranes (CIM) have recently been introduced to another National Health Service (NHS) eye unit (St Paul's Eye Unit, Liverpoo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: Royal Infirmary of Edinburgh, Edinburgh, Not set
Conditions: Corneal Ulcer (Diagnosis)
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Efficacy of [18F]Florbetaben PET for Diagnosis of Cardiac AL Amyloidosis
NCT05184088
Recruiting
This is an open-label, multi-center pivotal Phase 3 study to visually and quantitatively assess PET images obtained after single application of 300 MBq \[18F\]florbetaben and PET scanning of patients with suspected cardiac amyloidosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2025
Locations: St Luke's Hospital, Kansas City, Kansas +13 locations
Conditions: Cardiac Amyloidosis, AL Amyloidosis, ATTR Amyloidosis
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Realistic Computational Electrophysiology Simulations for the Targetted Treatment of Atrial Fibrillation
NCT05057507
Recruiting
The aim of this research is to classify patients by the dominant mechanism of continuous atrial electrical activation during atrial fibrillation. This approach seeks to improve on existing classifications which are based solely on the duration of the arrhythmia (\<7 days, \>7 days and \>1 year). This is a cohort study. Patients undergoing clinically indicated electrophysiology study or AF ablation will have invasive assessment of cardiac electrophysiological profile at the time of their planned... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/23/2025
Locations: NHS Lothian, Edinburgh, Not set +1 locations
Conditions: Atrial Fibrillation
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Near Fatal Asthma in Children and Young People
NCT05632588
Recruiting
This study will report the frequency, risks factors, clinical care and estimate the future asthma risk of children and young people (aged 5-15 years) experiencing a Delphi defined near fatal asthma (NFA) attacks in the United Kingdom (UK) and Republic of Ireland (ROI). A greater understanding of the frequency and risk factors associated with NFA could help support children and young people (CYP), parents and clinicians to identify and modify risk, both independently and through a resulting clini... Read More
Gender:
ALL
Ages:
Between 5 years and 15 years
Trial Updated:
06/23/2025
Locations: University of Edinburgh, Edinburgh, Not set
Conditions: Near Fatal Asthma
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MEASuRE: Metreleptin Effectiveness And Safety Registry
NCT02325674
Recruiting
The study is a post-authorization, prospective, voluntary registry of patients treated with commercial metreleptin including, but not limited to, patients in the US and EEA.
Gender:
ALL
Ages:
All
Trial Updated:
06/20/2025
Locations: University Alabama at Birmingham, Birmingham, Alabama +27 locations
Conditions: Generalised Lipodystrophy, Partial Lipodystrophy
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