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All Clinical Trials in United Kingdom
A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1045 - 1056 of 3097
A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)
Recruiting
The primary purpose of the study is to transition participants into an extension study to collect long-term safety and efficacy data. The study will include participants who are safely tolerating bomedemstat, receiving clinical benefit from its use in estimation of the investigator, and have shown the following criteria:
* Participants from the IMG-7289-202/MK-3543-005 (NCT05223920) study must have received at least 6 months of treatment with bomedemstat;
* Essential thrombocythemia (ET) and po... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/20/2025
Locations: University of Michigan ( Site 6000), Ann Arbor, Michigan +20 locations
Conditions: Thrombocythemia, Essential, Primary Myelofibrosis, Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera
A Study of Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With T-cell Redirectors Outside of Clinical Trials
Recruiting
The purpose of this study is to describe the use of teclistamab/talquetamab in the treatment of patients with RRMM outside of clinical trials.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/20/2025
Locations: Aalborg Sygehus Syd, Aalborg, Not set +46 locations
Conditions: Relapsed/Refractory Multiple Myeloma (RRMM)
MEASuRE: Metreleptin Effectiveness And Safety Registry
Recruiting
The study is a post-authorization, prospective, voluntary registry of patients treated with commercial metreleptin including, but not limited to, patients in the US and EEA.
Gender:
ALL
Ages:
All
Trial Updated:
06/20/2025
Locations: University Alabama at Birmingham, Birmingham, Alabama +27 locations
Conditions: Generalised Lipodystrophy, Partial Lipodystrophy
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors
Recruiting
The goal of this study is to assess the safety and tolerability of GSK5733584. The study will also see how the levels of GSK5733584 change over time at different dose amount.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: GSK Investigational Site, Lake Mary, Florida +46 locations
Conditions: Solid Tumors, Neoplasms
An Open-label Study to Evaluate the Pharmacokinetics and Safety of Bimekizumab in Pediatric Study Participants With Active Juvenile Idiopathic Arthritis Subtypes Enthesitis-related Arthritis (Including Juvenile-onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis
Recruiting
The purpose of this study is to assess plasma bimekizumab concentrations following subcutaneous (sc) bimekizumab administration.
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
06/19/2025
Locations: Ja0005 50646, Calgary, Not set +19 locations
Conditions: Enthesitis-related Arthritis, Juvenile Psoriatic Arthritis
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
Recruiting
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: Phoenician Centers for Research & Innovation, Phoenix, Arizona +54 locations
Conditions: Chronic Pain
Different Doses of BI-1607 in Combination With Pembrolizumab and Ipilimumab, in Participants With Unresectable or Metastatic Melanoma
Recruiting
Why the research is needed: Researchers are looking for a better way to treat melanoma that has spread or cannot be removed surgically. Melanoma is a type of skin cancer that starts in melanocytes, the cells that make the pigment that gives skin its color. In people with cancer, the body cannot control the growth of cells, which can come together to form tumors. This trial's new treatment is called BI-1607. BI-1607 is designed to work by improving the effectiveness of other targeted therapies al... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: Charité - Universitatsmedizin Berlin, Berlin, Not set +8 locations
Conditions: Melanoma Metastatic, Melanoma of Skin, Melanoma BRAF V600E/K Mutated, Melanoma Recurrent, Melanoma Stage III or IV, Melanoma, Melanoma Negative for BRAF, Melanoma Negative for NRAS, Melanomas, Uveal Melanoma, Metastatic
Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve
Recruiting
Collect real-world data on acute and long-term safety and performance of the MITRIS RESILIA Mitral Valve, Model 11400M, in subjects requiring replacement of their native or prosthetic mitral valve with or without concomitant procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: University of Alabama Hospital, Birmingham, Alabama +36 locations
Conditions: Mitral Stenosis, Mitral Valve Insufficiency
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
Recruiting
The primary objective of the FALCON study is to evaluate the efficacy of KL1333 on selected disease manifestations of primary mitochondrial disease (PMD) following 48 weeks of treatment. This objective involves evaluating the efficacy of KL1333 versus placebo on fatigue symptoms and impacts on daily living as well as on functional lower extremity strength and endurance. Additionally, the study evaluates the safety and tolerability of KL1333.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: Akron Children's Hospital, Akron, Ohio +22 locations
Conditions: Primary Mitochondrial Disease
STOP Persistent AF PAS
Recruiting
The STOP Persistent AF Post Approval Study (PAS) is a prospective, global, multicenter, observational trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: Hartford Hospital, Hartford, Connecticut +16 locations
Conditions: Persistent Atrial Fibrillation
A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
Recruiting
The primary objective of this study is to assess short, mid and long-term clinical outcomes in patients with difficult to treat depression (such as patients with treatment resistant depression) treated with Vagus Nerve Stimulation (VNS) Therapy as adjunctive therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: AKH Allgemeines Krankenhaus der Stadt Wien, Vienna, Not set +17 locations
Conditions: Treatment Resistant Depression
A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
Recruiting
This study is being conducted to evaluate the safety, tolerability, and dose-limiting toxicity (DLT) and determine the maximum tolerated dose (MTD) and/or recommended dose(s) for expansion (RDE) of INCA033989 administered as a monotherapy or in combination with ruxolitinib in participants with myeloproliferative neoplasms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: Royal Brisbane and Women'S Hospital, Herston, Queensland +28 locations
Conditions: Myeloproliferative Neoplasms
1045 - 1056 of 3097
