All Clinical Trials in United Kingdom

A listing of 3097 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors

NCT06431594

Recruiting

The goal of this study is to assess the safety and tolerability of GSK5733584. The study will also see how the levels of GSK5733584 change over time at different dose amount.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/19/2025

Locations: GSK Investigational Site, Lake Mary, Florida +46 locations

GSK Investigational Site, Lake Mary, Florida

GSK Investigational Site, Fairway, Kansas

GSK Investigational Site, Boston, Massachusetts

GSK Investigational Site, Detroit, Michigan

GSK Investigational Site, Grand Rapids, Michigan

GSK Investigational Site, Nashville, Tennessee

GSK Investigational Site, Dallas, Texas

GSK Investigational Site, West Valley City, Utah

GSK Investigational Site, Cipoletti Rio Negro, Not set

GSK Investigational Site, Ciudad de Buenos Aires, Not set

GSK Investigational Site, Rosario, Not set

GSK Investigational Site, Blacktown, New South Wales

GSK Investigational Site, Macquarie University, New South Wales

GSK Investigational Site, Leuven, Not set

GSK Investigational Site, Ottawa, Ontario

GSK Investigational Site, Toronto, Ontario

GSK Investigational Site, Montreal, Quebec

GSK Investigational Site, Helsinki, Not set

GSK Investigational Site, Tampere, Not set

GSK Investigational Site, Lyon Cedex 08, Not set

GSK Investigational Site, Saint Herblain, Not set

GSK Investigational Site, Villejuif cedex, Not set

GSK Investigational Site, Roma, Not set

GSK Investigational Site, Rozzano MI, Not set

GSK Investigational Site, Saitama, Not set

GSK Investigational Site, Shizuoka, Not set

GSK Investigational Site, Tokyo, Not set

GSK Investigational Site, Gyeonggi-do, Not set

GSK Investigational Site, Seoul, Not set

GSK Investigational Site, Amsterdam, Not set

GSK Investigational Site, Barcelona, Not set

GSK Investigational Site, COrdoba, Not set

GSK Investigational Site, Girona, Not set

GSK Investigational Site, Madrid, Not set

GSK Investigational Site, Pozuelo De AlarcOn Madr, Not set

GSK Investigational Site, Stockholm, Not set

GSK Investigational Site, Uppsala, Not set

GSK Investigational Site, Cambridge, Not set

GSK Investigational Site, London, Not set

Conditions: Solid Tumors, Neoplasms

Learn More ›

Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

NCT05526560

Recruiting

Collect real-world data on acute and long-term safety and performance of the MITRIS RESILIA Mitral Valve, Model 11400M, in subjects requiring replacement of their native or prosthetic mitral valve with or without concomitant procedures.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/19/2025

Locations: University of Alabama Hospital, Birmingham, Alabama +36 locations

University of Alabama Hospital, Birmingham, Alabama

University of Southern California, Los Angeles, California

Hoag Memorial Hospital Presbyterian, Newport Beach, California

Stanford University, Palo Alto, California

AdventHealth Orlando, Orlando, Florida

Piedmont Heart Institute, Athens, Georgia

Piedmont Heart Institute, Atlanta, Georgia

Ascension St. Vincent Heart Center, Carmel, Indiana

University of Michigan, Ann Arbor, Michigan

Mayo Clinic, Rochester, Rochester, Minnesota

Washington University Barnes-Jewish Hospital, Saint Louis, Missouri

Mount Sinai Hospital, New York, New York

Columbia University Irving Medical Center, New York, New York

Weill Cornell Medicine, New York, New York

Duke University Medical Center, Durham, North Carolina

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

Allegheny General Hospital, Pittsburgh, Pennsylvania

UPMC Presbyterian Shadyside, Pittsburgh, Pennsylvania

Tristar Centennial Medical Center, Nashville, Tennessee

Ascension Saint Thomas, Nashville, Tennessee

University of Utah, Salt Lake City, Utah

Mayo Clinic Health System - Eau Claire, Eau Claire, Wisconsin

Aurora St. Luke's Medical Center, Milwaukee, Wisconsin

St. Paul's Hospital and Vancouver General Hospital, Vancouver, British Columbia

London Health Sciences Centre, University Hospital (LHSC), London, Ontario

Montreal Heart Institute, Montréal, Quebec

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec, Not set

Universitätsklinikum Augsburg, Augsburg, Not set

Rhoen-Klinikum Campus Bad Neustadt, Bad Neustadt, Not set

Herz- und Diabeteszentrum NRW, Bad Oeynhausen, Not set

University Clinic Bonn, Bonn, Not set

Klinikum Links der Weser, Bremen, Not set

Deutsches Herzzentrum München, München, Not set

Royal Papworth Hospital, Cambridge, Not set

St. Thomas Hospital, London, Not set

King's College Hospital, London, Not set

Cleveland Clinic London, London, Not set

Conditions: Mitral Stenosis, Mitral Valve Insufficiency

Learn More ›

Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)

NCT06225596

Recruiting

This is a global, multicenter, randomized, open-label study, with an adaptive design. The main objective of the study is to measure the efficacy and safety of BT8009 (zelenectide pevedotin) as monotherapy and in combination with pembrolizumab in participants with locally advanced or metastatic urothelial cancer (UC). The study includes a dose selection phase followed by an adaptive design continuation. The study is comprised of 2 cohorts. Cohort 1 will include participants who have not received... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/19/2025

Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +169 locations

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Virginia K. Crosson Cancer Center at St. Jude Medical Center, Fullerton, California

University of California - Irvine Medical Center, Orange, California

Adventist Health St. Helena, Saint Helena, California

University of California, San Francisco (UCSF), San Francisco, California

Rocky Mountain Cancer Center, Denver, Colorado

Yale University School of Medicine - Yale Cancer Center, New Haven, Connecticut

Medical Oncology Hematology Consultants, Newark, Delaware

Cancer Specialists of North Florida, Jacksonville, Florida

Mount Sinai Medical Center of Florida, Inc., Miami Beach, Florida

University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida

AP Medical Research, Miami, Florida

Moffitt, Tampa, Florida

Southern Illinois University (SIU) - Simmons Cancer Institute, Springfield, Illinois

Mission Cancer + Blood, Des Moines, Iowa

University of Kansas Cancer Center, Westwood, Kansas

UofL Health Brown Cancer Center, Louisville, Kentucky

Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana

Princess Margaret Hospital, Grand Rapids, Michigan

Nebraska Cancer Specialists, Omaha, Nebraska

XCancer Omaha/Urology Cancer Center, Omaha, Nebraska

Astera Cancer Care, East Brunswick, New Jersey

Summit Health (New Jersey Urology), Voorhees, New Jersey

Montefiore Medical Center, Bronx, New York

Columbia University Irving Medical Center, New York, New York

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Medical University of South Carolina (MUSC) - Hollings Cancer Center, Charleston, South Carolina

Carolina Urologic Research Center, Myrtle Beach, South Carolina

SCRI Oncology Partners, Nashville, Tennessee

The Center for Cancer and Blood Disorders, Fort Worth, Texas

MD Anderson Cancer Center, Houston, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Centro de Diagnostico Urologico S.R.L., Buenos Aires, Not set

Hospital Britanico de Buenos Aires, Buenos Aires, Not set

Hospital Sirio Libanes de Buenos Aires, Buenos Aires, Not set

Instituto Alexander Fleming, Buenos Aires, Not set

Fundacion Medica Rio Negro y Neuquen, Cipolletti, Not set

Centro Medico Privado (CEMAIC), Córdoba, Not set

Fundación CORI para la investigación y Prevención del Cancer, La Rioja, Not set

Centro De Investigacion Pergamino S.A., Pergamino, Not set

Instituto de Oncologia de Rosario, Santa Fe, Not set

Clinica Viedma S.A., Viedma, Not set

Cancer Research SA, Adelaide, Not set

Mater Misericordiae Ltd, South Brisbane, Brisbane, Not set

Townsville Hospital and Health Service, Douglas, Not set

Barwon Health, Geelong, Not set

Calvary Mater Newcastle, Hunter, Not set

Sir Charles Gairdner Hospital, Nedlands, Not set

Blacktown Hospital, New South Wales, Not set

Prince of Wales Hospital, Randwick, Not set

Icon Cancer Centre, South Brisbane, Not set

Gold Coast University Hospital, Southport, Not set

Princess Alexandra Hospital, Woolloongabba, Not set

Urologie und Andrologie Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set

Krankenhaus der Barmherzigen Brüder Wien, Wien, Not set

Medizinische Universitaet Wien, Wien, Not set

ASBL Grand Hôpital de Charleroi (GHdC), Site Notre Dame, Charleroi, Not set

General Hospital Maria Middelares, Gent, Not set

University Hospital Gent, Gent, Not set

Universitaire Ziekenhuizen Leuven, Leuven, Not set

Fundacao PIO XII - Hospital de Amor, Barretos, Not set

CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina, Florianópolis, Not set

Oncosite - Centro de Pesquisa Clinica Em Oncologia, Ijuí, Not set

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa, Porto Alegre, Not set

Hospital Sao Lucas - Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, Not set

Hospital Alemao Oswaldo Cruz, São Paulo, Not set

Hospital A.C. Camargo Cancer Center, São Paulo, Not set

British Columbia Cancer Agency- Centre for the Southern Interior, Kelowna, Not set

McGill University Health Center, Québec, Not set

Princess Margaret Hospital, Toronto, Not set

Cancer Care Manitoba, Winnipeg, Not set

Fundación Arturo López Pérez (FALP), Santiago, Not set

Centro de Investigacion Clinica Bradford Hill, Santiago, Not set

Oncocentro APYS, Viña Del Mar, Not set

Aalborg University Hospital, Aalborg, Not set

Service d'Oncologie Medicale - CHRU Besancon, Besançon, Not set

Institut Bergonie, Bordeaux Cedex, Not set

CHU Bordeaux - Hopital Saint-Andre, Bordeaux, Not set

Groupement de Cooperation Sanitaire (GCS) ELSAN - Clinique Victor Hugo, Le Mans, Not set

CHU de Limoges - Hopital Dupuytren 1, Limoges, Not set

Centre Leon Berard, Lyon, Not set

Institut Paoli-Calmettes, Marseille, Not set

ICM - Institut Regional du Cancer de Montpellier, Montpellier Cedex 5, Not set

Centre d'Oncologie de Gentilly, Nancy, Not set

Centre Antoine-Lacassagne, Nice, Not set

Institut Mutualiste Montsouris, Paris, Not set

AP-HP Hopital Europeen Georges Pompidou, Paris, Not set

HCL Centre Hospitalier Lyon Sud, Pierre-Benite Cedex, Not set

CHU Poitiers - Pole Regional de Cancerologie de Poitiers (PRC), Poitiers, Not set

Institut Gustave Roussy, Villejuif, Not set

LTD High Technology Hospital Medcenter, Batumi, Not set

The First University Clinic of Tbilisi State Medical University, Tbilisi, Not set

New Vision University Hospital, Tbilisi, Not set

Multiprofile Clinic Consilium Medulla LTD, Tbilisi, Not set

Universitaetsklinikum Carl Gustav Carus Dresden, Dresden, Not set

Universitaetsklinikum Essen, Essen, Not set

Krankenhaus Nordwest GmbH, Frankfurt, Not set

Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe Universitaet, Frankfurt, Not set

Universitaetsklinikum Freiburg, Freiburg, Not set

Georg-August-Universitaet Goettingen Stiftung oeffentlichen Rechts Universitaetsmedizin Goettingen, Göttingen, Not set

Marien Hospital Herne - Universitaetsklinikum der Ruhr-Universitaet Bochum, Herne, Not set

Universitaetsmedizin Mannheim, Mannheim, Not set

Universitaetsklinikum Muenster, Münster, Not set

Studienpraxis Urologie, Nürtingen, Not set

Universitaetsklinikum Tuebingen, Tübingen, Not set

Orszagos Onkologiai Intezet, Budapest, Not set

Budapesti Uzsoki Utcai Korhaz, Budapest, Not set

Somogy Varmegyei Kaposi Mor Oktato Korhaz, Kaposvár, Not set

Bacs-Kiskun Varmegyei Oktatokorhaz, Kecskemét, Not set

Shamir Medical Center, Be'er Ya'aqov, Not set

Rambam Health Care Campus, Haifa, Not set

Hadassah Hebrew University Medical Center, Jerusalem, Not set

Meir Medical Center, Kfar Saba, Not set

Rabin Medical Center - Beilinson Hospital, Petach Tikva, Not set

Sourasky Medical Center, Tel Aviv, Not set

Centro Riferimento Oncologico - Aviano, Aviano, Not set

Ospedale Policlinico San Martino IRCCS, Genova, Not set

Istituto Europeo di Oncologia, Milano, Not set

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Napoli, Not set

Azienda Ospedaliera Santa Maria di Terni, Terni, Not set

Chungnam National University Hospital, Daejeon, Not set

National Cancer Center, Goyang, Not set

Chonnam National University Hwasun Hospital, Gwangju, Not set

Korea University Anam Hospital, Seoul, Not set

Seoul National University Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Severance Hospital, Yonsei University Health System, Seoul, Not set

Copernicus PL Sp. z o.o., Wojewodzkie Centrum Onkologii, Gdańsk, Not set

Spitale Pomorskie Sp.z.o.o ODDZIAL ONKOLOGII KLINICZNEJ, Gdynia, Not set

SCM Sp. z o.o., Kraków, Not set

Mazowiecki Szpital Onkologiczny, Wieliszew, Not set

University Clinical Center of Serbia, Clinic of Urology, Belgrade, Not set

National University Hospital, Singapore, Not set

National Cancer Centre Singapore, Singapore, Not set

Hospital de la Santa Creu i Sant Pau, Barcelona, Not set

Hospital Clinic Barcelona, Barcelona, Not set

Institut Catala d'Oncologia - L'Hospitalet, Barcelona, Not set

Hospital Universitario Insular de Gran Canaria, Las Palmas De Gran Canaria, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

Clinica Universidad de Navarra - Madrid, Madrid, Not set

Hospital Fundacion Jimenez Diaz, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Clinica Universidad de Navarra - Pamplona, Pamplona, Not set

Hospital Universitario Donostia, San Sebastián, Not set

Hospital Universitario Marques de Valdecilla, Santander, Not set

Hospital Clinico Universitario de Santiago, Santiago De Compostela, Not set

Instituto Valenciano de Oncologia, Valencia, Not set

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set

China Medical University Hospital, Taichung, Not set

National Cheng Kung University Hospital, Tainan, Not set

Chi Mei Medical Center, Tainan, Not set

National Taiwan University Hospital, Taipei, Not set

Linkou Chang Gung Memorial Hospital (CGMHLK), Taoyuan city, Not set

Liv Hospital Ankara, Ankara, Not set

Trakya University Medical Faculty, Edirne, Not set

Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Not set

Istinye Universitesi VM Medical Park Pendik Hastanesi, Istanbul, Not set

Medical Point Izmir Hospital, İzmir, Not set

Kocaeli University Faculty of Medicine, Kocaeli, Not set

Bristol Haematology and Oncology Centre, Bristol, Not set

Addenbrooke's Hospital, Cambridge, Not set

St. Bartholomew's Hospital, London, Not set

University College London Hospital, London, Not set

Royal Free London NHS Foundation Trust, London, Not set

Charing Cross Hospital, London, Not set

The Christie NHS Foundation Trust, Manchester, Not set

Derriford Hospital, Plymouth, Not set

The Royal Marsden Hospital, Sutton, Not set

Conditions: Metastatic Urothelial Cancer

Learn More ›

Stereotactic Ablative Radiotherapy for the Treatment of Refractory Ventricular Tachycardia

NCT05696522

Recruiting

Ventricular tachycardia (VT) is an abnormal rhythm arising from the bottom chambers (ventricles) of the heart. The hearts of most patients who develop VT have been previously damaged by a myocardial infarction (heart attack) or other heart muscle diseases (cardiomyopathies). The damage produces scar or fatty deposits that conduct electrical impulses slowly allowing VT to occur. Recurrent episodes of VT can compromise heart function and increase mortality. VT is prevented by special drugs but th... Read More

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

06/18/2025

Locations: St Bartholomew's Hospital, London, Not set

Conditions: Radiotherapy; Complications, Ventricular Tachycardia, Structural Heart Abnormality, Heart Failure

Learn More ›

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

NCT02468024

Recruiting

To Determine if SAbR improves survival over SR in High Risk Operable Stage I NSCLC

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: UCSD, La Jolla, California +49 locations

UCSD, La Jolla, California

University of Colorado/Memorial, Aurora, Colorado

Penrose Cancer Center, Colorado Springs, Colorado

Boca Raton Regional Hospital, Boca Raton, Florida

Curtis and Elizabeth Anderson Cancer, Savannah, Georgia

University of Iowa, Iowa City, Iowa

University of Kansas Medical Center, Kansas City, Kansas

University of Kentucky Health Care, Lexington, Kentucky

University of Louisville Physicians, Louisville, Kentucky

Ochsner Medical Center, New Orleans, Louisiana

Luminis Health Research Institute, Annapolis, Maryland

University of Maryland Medical Center, Baltimore, Maryland

Boston Medical Center, Boston, Massachusetts

Henry Ford Health System, Detroit, Michigan

Beaumont, Royal Oak, Michigan

Mayo Clinic Rochester, Rochester, Minnesota

Meridian Health System, Neptune, New Jersey

New York University Langone Medical Center, New York, New York

SUNY - Upsate Medical Centre, Syracuse, New York

University of North Carolina, Chapel Hill, North Carolina

Wake Forest Baptist Health, Winston-Salem, North Carolina

University of Cincinnati, Cincinnati, Ohio

Case Western (University Hospitals Case Medical Center), Cleveland, Ohio

Cleveland Clinic, Cleveland, Ohio

Ohio State University Wexner Medical Center, Columbus, Ohio

Providence Health & Services/Oregon Clinic, Portland, Oregon

Thomas Jefferson University, Philadelphia, Pennsylvania

UPMC Health System, Pittsburgh, Pennsylvania

Allegheny, Pittsburg, Pennsylvania

Mount Nittany, State College, Pennsylvania

Lifespan Oncology Clinical Research, Providence, Rhode Island

University of Tennessee Health Science Center, Memphis, Tennessee

Cardiothoracic and Vascular Surgeons, Austin, Texas

University of Texas Southwestern Medical Center, Dallas, Texas

Intermountain Medical Center, Salt Lake City, Utah

University of Virginia Health System, Charlottesville, Virginia

Inova Fairfax Medical Campus, Falls Church, Virginia

Swedish Cancer Institute, Seattle, Washington

Medical College of Wisconsin, Milwaukee, Wisconsin

Clement Zablocki VA Medical Center, Milwaukee, Wisconsin

St. Vincent's Hospital Melbourne, Fitzroy, Melbourne

St. Vincent's/Peter Mac, Fitzroy, Victoria

Barwon Health - Uni Hospital Geelong, Geelong, Victoria

Lawson Health Science Center, London, Ontario, Canada

Ottawa Hospital Cancer Center, Ottawa, Ontario

UHN-Toronto, Toronto, Ontario

CHUM, Montréal, Quebec

Trillium Health Partners, Mississauga, Not set

Sunnybrook Health Sciences Centre, Toronto, Not set

The James Cook University Hospital, Middlesbrough, Not set

Conditions: Non-Small Cell Lung Cancer

Learn More ›

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

NCT03645928

Recruiting

A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL \[LN-144/LN-145 (lifileucel)\] in combination with immune checkpoint inhibitors or TIL \[LN-144/LN-145 (lifileucel) and LN-145-S1\] as a single agent therapy.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: University of California, San Diego, La Jolla, California +44 locations

University of California, San Diego, La Jolla, California

University of Southern California, Los Angeles, California

University of California, Los Angeles, Los Angeles, California

University of Colorado, Denver, Colorado

Yale University, New Haven, Connecticut

Georgetown University Medical Center, Washington, District of Columbia

Mount Sinai Medical Center, Miami Beach, Florida

Orlando Health Cancer Institute, Orlando, Florida

Moffitt Cancer Center, Tampa, Florida

University of Louisville, Louisville, Kentucky

University of Maryland, Baltimore, Maryland

Massachusetts General Hospital, Boston, Massachusetts

Karmanos Cancer Institute, Detroit, Michigan

Henry Ford Health System, Detroit, Michigan

MD Anderson at Cooper, Camden, New Jersey

Morristown Medical Center, Morristown, New Jersey

Columbia University, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

University of Cincinnati, Cincinnati, Ohio

Ohio State University, Columbus, Ohio

Avera Cancer Institute, Sioux Falls, South Dakota

Huntsman Cancer Hospital, Salt Lake City, Utah

Fred Hutchinson Cancer Research Center, Seattle, Washington

Medical College of Wisconsin, Milwaukee, Wisconsin

Princess Margaret Cancer Centre, Toronto, Ontario

Centre Léon Berard, Lyon, Not set

Klinikum rechts der Isar der Technischen Universität München, München, Bavaria

Universitätsklinikum Carl Gustav Carus, Dresden, Sachsen

Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck, Schleswig-Holstein

Laiko General Hospital of Athens, Athens, Attiki

Attikon University General Hospital, Athens, Attiki

Hospital Universitario Marques de Valdecilla, Santander, Cantabria

University Hospital Vall d'Hebron, Barcelona, Not set

ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona, Not set

Hospital General Universitario Gregorio Marañón, Madrid, Not set

Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario HM Sanchinarro, Madrid, Not set

Hospital Regional Universitario de Malaga - Hospital General, Málaga, Not set

Universitätsspital Basel, Basel, Not set

Universitaetsspital Bern, Bern, Not set

Centre Hospitalier Universitaire Vaudois, Lausanne, Not set

Guy's Hospital, London, England

The Royal Marsden NHS Foundation Trust, London, England

Bristol Haematology and Oncology Centre, Bristol, Not set

Conditions: Metastatic Melanoma, Squamous Cell Carcinoma of the Head and Neck, Non-small Cell Lung Cancer

Learn More ›

DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

NCT05566795

Recruiting

This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of tovorafenib monotherapy versus standard of care (SoC) chemotherapy in participants with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring first-line systemic therapy.

Gender:

ALL

Ages:

25 years and below

Trial Updated:

06/18/2025

Locations: Children's of Alabama, Birmingham, Alabama +122 locations

Children's of Alabama, Birmingham, Alabama

Phoenix Children's Hospital, Phoenix, Arizona

Children's Hospital Los Angeles, Los Angeles, California

Children's Hospital of Orange County Main Campus - Orange, Orange, California

UCSF Benioff Children's Hospital, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Connecticut Children's Medical Center, Hartford, Connecticut

Children's National Medical Center, Washington, District of Columbia

University of Florida Health, Gainesville, Florida

Arnold Palmer Hospital for Children, Orlando, Florida

Johns Hopkins All Children's Hospital, St. Petersburg, Florida

Children's Healthcare of Atlanta, Atlanta, Georgia

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana

Maine Children's Cancer Program, Scarborough, Maine

Dana-Farber Cancer Institute, Boston, Massachusetts

University of Michigan - - C.S. Mott Children's Hospital, Ann Arbor, Michigan

Children's Minnesota, Minneapolis, Minnesota

St. Louis Children's Hospital, Saint Louis, Missouri

University of Nebraska Medical Center, Omaha, Nebraska

New York University Langone Health, New York, New York

University of Rochester, Rochester, New York

Duke Cancer Institute, Durham, North Carolina

Cleveland Clinic Main Campus, Cleveland, Ohio

University of Texas Southwestern Medical Center, Dallas, Texas

Texas Children's Hospital, Houston, Texas

Seattle Children's Hospital, Seattle, Washington

University of Wisconsin - Madison, Madison, Wisconsin

Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland

Perth Children's Hospital, Nedlands, Not set

Women's and Children's Health Network, North Adelaide, Not set

The Royal Children's Hospital - Children's Cancer Centre, Parkville, Not set

Sydney Children's Hospital - Randwick, Randwick, Not set

Children's Hospital at Westmead, Westmead, Not set

Medizinische Universität Innsbruck, Innsbruck, Tirol

Medizinische Universität Wien, Wien, Not set

Cliniques Universitaires Saint-Luc, Brussel, Not set

Universitair Ziekenhuis Gent, Ghent, Not set

Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Not set

Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), São Paulo, Not set

Alberta Children's Hospital, Calgary, Alberta

Stollery Children's Hospital, Edmonton, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

McMaster Children's Hospital, Hamilton, Ontario

Children's Hospital of Eastern Ontario, Ottawa, Ontario

CHU Sainte-Justine, Montréal, Quebec

The Montreal Children's Hospital, Montréal, Quebec

Centre Hospitalier de l'Université Laval et Centre Mère-Enfant Soleil, Québec, Not set

SickKids - The Hospital for Sick Children, Toronto, Not set

Fakultní Nemocnice Brno - D?tská Nemocnice, Brno, Not set

Motol University Hospital, Prague, Not set

Aarhus Universitetshospital, Aarhus, Midtjylland

Rigshospitalet, Copenhagen, Not set

Helsingin yliopistollinen sairaala (HUS), Helsinki, Not set

Tampereen Yliopistollinen Sairaala, Tampere, Not set

Centre de Lutte contre le Cancer - Centre Oscar Lambret, Lille, Not set

Centre Léon Bérard, Lyon, Not set

Hôpital de la Timone, Marseille, Not set

Institut Curie, Paris, Not set

Gustave Roussy, Villejuif, Not set

Universitätsklinikum Freiburg, Freiburg, Baden-Württemberg

Universitätsklinikum Augsburg, Augsburg, Bayern

Universitätsklinikum Erlangen, Erlangen, Bayern

Universitätsklinikum Würzburg, Würzburg, Bayern

Universitätsklinikum Frankfurt, Frankfurt, Hessen

Medizinische Hochschule Hannover, Hannover, Niedersachsen

Universitaetsklinikum Essen, Essen, Nordrhein-Westfalen

Universitätsklinikum Leipzig, Leipzig, Sachsen

Charité Universitätsmedizin Berlin, Berlin, Not set

Evangelische Klinikum Bethel (EvKB), Bielefeld, Not set

Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set

Universitätsklinikum Heidelberg, Heidelberg, Not set

Universitätsklinikum Tübingen, Tübingen, Not set

Aghia Sofia General Children's Hospital, Athens, Not set

Athens General Children's Hospital, Athens, Not set

Semmelweis Egyetem Tűzoltó utcai II. Sz. Gyermekgyógyászati Kliniká, Budapest, Not set

Children's Health Ireland at Crumlin, Crumlin, Dublin

Schneider Children's Medical Center of Israel, Petah tikva, Not set

The Edmond and Lily Safra Children's Hospital, Ramat Gan, Not set

Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Milan

Ospedale Pediatrico Bambino Gesù, Roma, Rome

Ospedale Infantile Regina Margherita, Torino, Turin

Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari, Bari, Not set

Istituto Giannina Gaslini, Genova, Not set

Azienda Ospedaliera di Rilievo Nazional Santobono Pausilipon, Napoli, Not set

Azienda Ospedale Università di Padova, Padova, Not set

Azienda Sanitaria Universitaria Friuli Centrale - P.O. Santa Maria della Misericordia, Udine, Not set

King Hussein Cancer Foundation - King Hussein Cancer Center, Amman, Muhafazat al-Asima

Seoul National University Hospital, Seoul, Not set

Severance Hospital, Seoul, Not set

Prinses Maxima Centrum Kinderoncologie, Utrecht, Not set

Starship Paediatric Blood & Cancer Center, Grafton, Not set

Universitetssykehuset Nord-Norge - Tromsø, Tromsø, Troms

Oslo Universitetssykehus, Oslo, Not set

SingHealth Group - KK Women's and Children's Hospital, Singapore, Not set

Univerzitetni Klinini Center Ljubljana, Ljubljana, Not set

Hospital Universitario Cruces, Barakaldo, Not set

Hospital Universitari Vall d'Hebrón, Barcelona, Not set

Hospital Sant Joan de Déu Barcelona, Barcelona, Not set

Hospital Infantil Universitario Niño Jesús, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Virgen del Rocío, Sevilla, Not set

Hospital Universitari i Politècnic La Fe, Valencia, Not set

Drottning Silvias barn- och ungdomssjukhus, Göteborg, Not set

Skånes Universitetssjukhus - Lund, Lund, Not set

Astrid Lindgrens Barnsjukhus Solna, Stockholm, Not set

Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Not set

Universitaets - Kinderspital Zürich, Zurich, Not set

Taipei Medical University Hospital, Taipei, Not set

Chang Gung Memorial Hospital - Linkou Branch, Taoyuan, Not set

Birmingham Women's and Children's NHS Foundation Trust, Birmingham, England

Leeds Teaching Hospital NHS Trust, Leeds, England

Alder Hey Children's NHS Foundation Trust, Liverpool, England

Manchester University NHS Foundation Trust, Manchester, England

The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, England

Great Ormond Street Hospital for Children, Oxford, England

University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire

Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland

NHS Greater Glasgow and Clyde, Glasgow, Scotland

Sheffield Children's Hospital, Sheffield, South Yorkshire

The Royal Marsden NHS Foundation Trust, Sutton, Surrey

University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, Not set

Cambridge University Hospitals NHS Foundation Trust, Cambridge, Not set

Conditions: Low-grade Glioma, Rapidly Accelerated Fibrosarcoma (RAF) Altered Glioma, Pediatric Low-grade Glioma

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A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)

NCT06483334

Recruiting

This study is a substudy being conducted under one pembrolizumab umbrella master study KEYMAKER-U04. The substudy will consist of 2 parts. Part 1 will evaluate the safety and preliminary efficacy of sacituzumab tirumotecan plus enfortumab vedotin (EV). Part 2 will be based on Part 1 results and will evaluate the efficacy, pharmacokinetics, and safety of sacituzumab tirumotecan plus EV in combination with pembrolizumab in participants with advanced urothelial carcinoma.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: University of California San Francisco HDFCCC ( Site 4044), San Francisco, California +23 locations

University of California San Francisco HDFCCC ( Site 4044), San Francisco, California

Indiana University Melvin and Bren Simon Cancer Center ( Site 4011), Indianapolis, Indiana

Dana-Farber Cancer Institute ( Site 4047), Boston, Massachusetts

Siteman Cancer Center ( Site 4038), Saint Louis, Missouri

Icahn School of Medicine at Mount Sinai ( Site 4018), New York, New York

Cleveland Clinic-Taussig Cancer Center ( Site 4036), Cleveland, Ohio

Huntsman Cancer Institute-HCI Clinical Trials Office ( Site 4041), Salt Lake City, Utah

The Ottawa Hospital - General Campus ( Site 4105), Ottawa, Ontario

Princess Margaret Cancer Centre ( Site 4106), Toronto, Ontario

Centre Hospitalier Lyon Sud ( Site 4606), Pierre-Benite, Rhone-Alpes

Rambam Health Care Campus ( Site 4501), Haifa, Not set

Rabin Medical Center-Oncology ( Site 4504), Petah Tikva, Not set

Sheba Medical Center-ONCOLOGY ( Site 4503), Ramat Gan, Not set

Ospedale San Raffaele-Oncologia Medica ( Site 4403), Milano, Lombardia

Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 4405), Milano, Not set

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 4406), Napoli, Not set

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 4903), Seoul, Not set

Asan Medical Center-Department of Oncology ( Site 4901), Seoul, Not set

Samsung Medical Center ( Site 4902), Seoul, Not set

Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 4302), Amsterdam, Noord-Holland

Hospital Universitari Vall d'Hebron-Oncology ( Site 4767), Barcelona, Not set

Hospital Clinico San Carlos ( Site 4765), Madrid, Not set

National Cheng Kung University Hospital-Clinical Trial Center ( Site 4803), Tainan, Not set

St Bartholomew s Hospital ( Site 4206), London, London, City Of

Conditions: Metastatic Urothelial Carcinoma, Locally Advanced Urothelial Carcinoma

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EMITT-1 (ERAP Mediated Immunopeptidome Targeting Trial - 1)

NCT06923761

Recruiting

This is a Phase I/II, open-label, first-in human study of GRWD5769 alone, and in combination with another anti-cancer agent in advanced solid cancers.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: GenesisCare Research, Adelaide, Not set +28 locations

GenesisCare Research, Adelaide, Not set

Southern Oncology Clinical Research Unit (SOCRU), Bedford Park, Not set

Blacktown Hospital, Blacktown, Not set

Kinghorn Cancer Centre (KCC), Darlinghurst, Not set

Austin Health, Heidelberg, Not set

Alfred Health, Melbourne, Not set

Mater Research, South Brisbane, Not set

Cancer Care Wollongong, Wollongong, Not set

Centre Léon Bérard, Lyon Cedex, Not set

Institut Paoli-Calmettes, Marseille, Not set

Centre Eugène Marquis, Rennes, Not set

Institut de Cancérologie de l'Ouest (ICO), Saint-Herblain Cedex, Not set

ICANS - Institut de Cancérologie Strasbourg, Strasbourg, Not set

IUCT Oncopole - Institut Claudius Regaud, Toulouse, Not set

Institut Gustave Roussy, Villejuif, Not set

Hospital Universitario Vall d'Hebrón (VHIO), Barcelona, Not set

START Barcelona - Hospital HM Nou Delfos, Barcelona, Not set

Clinica Universitaria de Navarra Madrid, Madrid, Not set

START Madrid - Centro Integral Oncológico Clara Campal (HM CIOCC), Madrid, Not set

START Madrid - Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set

Hospital Universitario Virgen de la Victoria, Malaga, Not set

Clinica Universitaria de Navarra Pamplona, Pamplona, Not set

INCLIVA-Hospital Clínico Universitario de Valencia, Valencia, Not set

Western General Hospital, Edinburgh, Not set

Clatterbridge Cancer Centre, Liverpool, Not set

Hammersmith Hospitals NHS Trust, London, Not set

Royal Free Hospital, London, Not set

Christie NHS Foundation Trust, Manchester, Not set

Newcastle Upon Tyne Hospital, Newcastle, Not set

Conditions: Advanced Solid Malignancy

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Εffectiveness of a Digital Social Intervention in Primary Care

NCT06849245

Recruiting

The goal of this study is to deliver a definitive randomised controlled trial to measure the effectiveness and assess cost-effectiveness of a digital social intervention for patients with asthma, composed of promoting engagement with online peer support in a primary care consultation, followed by engagement with online peer support for 12 months. The main questions/objectives this study aims to answer/address are: * Does promoting engagement with an online health community in primary care help... Read More

Gender:

ALL

Ages:

Between 18 years and 99 years

Trial Updated:

06/18/2025

Locations: North London Regional Research Delivery Network, London, Not set +3 locations

Conditions: Asthma Intermittent, Uncontrolled

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A Study of MOv18 IgE in Folate Receptor Alpha-expressing Platinum Resistant Ovarian Cancer

NCT06547840

Recruiting

EPS101-10-02 is a Phase Ib open label, multicentre clinical trial comprising of a Dose Escalation phase (Part 1) followed by a Dose Expansion phase (Part 2) of MOv18 IgE in patients with folate receptor alpha-expressing (5% or higher) platinum resistant ovarian cancer The dose escalation part of the study will primarily assess the safety and tolerability of MOv18 IgE in ascending dose cohorts, until the determination of the maximum tolerated dose (MTD) or maximum administered dose (MAD). Part... Read More

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: Bristol Haematology and Oncology Centre, Bristol, Not set +6 locations

Conditions: Advanced Ovarian Cancer, Platinum-resistant Ovarian Cancer

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Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

NCT06096116

Recruiting

The primary objective of this study is to evaluate the efficacy of two different doses of Atenativ, versus placebo, in restoring and maintaining heparin responsiveness in adult patients undergoing cardiac surgery necessitating cardiopulmonary bypass (CPB)

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

06/18/2025

Locations: Stanford University School of Medicine, Stanford, California +21 locations

Conditions: Acquired Antithrombin Deficiency

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