A Study to Evaluate the Effects of SAGE-718 in Participants With Parkinson's Disease Cognitive Impairment
Recruiting
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance in participants with Parkinson's disease mild cognitive impairment (PD-MCI).
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
11/02/2023
Locations: Sage Investigational Site, Burlington, Vermont
Conditions: Parkinson Disease, Cognitive Dysfunction
Fixed-Dose Trial in Early Parkinson's Disease (PD)
Recruiting
The purpose of this study is to evaluate the clinical efficacy, safety and pharmacokinetics (PK) of 2 fixed doses of tavapadon and placebo in participants with early PD.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
08/01/2023
Locations: Burlington, Vermont, Burlington, Vermont
Conditions: Parkinson Disease
Trial of Parkinson's And Zoledronic Acid
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: University of Vermont, Burlington, Vermont
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
Pyridostigmine for the Treatment of Constipation in Parkinson Disease
Recruiting
Constipation is a common and debilitating non-motor symptom of Parkinson disease (PD) that often precedes the onset of classic motor symptoms by decades. There is no standardized algorithm for managing constipation in this patient population, nor are there dedicated treatments. Studies suggest that constipation can affect quality of life to a significant degree, in many cases just as much as motor symptoms. There is an unmet need for effective treatment options for constipation in this patient p... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/15/2023
Locations: University of Vermont Medical Center, Burlington, Vermont
Conditions: Parkinson Disease, Constipation