The city of Seattle, Washington, currently has 10 active clinical trials seeking participants for Depression research studies.
RE104 Safety and Efficacy Study in Postpartum Depression
Recruiting
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms in participants with moderate-to-severe postpartum depression (PPD) as compared to active-placebo.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/18/2025
Locations: Reunion Investigational Site, Seattle, Washington
Conditions: Postpartum Depression
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Seattle Neuropsychiatric Treatment Center, Seattle, Washington
Conditions: Treatment Resistant Depression
Poststroke Depression in Hemorrhagic Stroke
Recruiting
A double-blinded placebo-controlled randomized trial to evaluate the effect of preventative treatment of depression in survivors of aneurysmal subarachnoid hemorrhage (aSAH), a type of stroke.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
03/25/2025
Locations: Harborview Medical Center, Seattle, Washington
Conditions: Stroke Hemorrhagic, Depression
IMAGINE: Pilot Trial of a Digital Group Intervention to Prevent Perinatal Depression
Recruiting
The goal of this clinical trial is to evaluate if a digital group intervention (named IMAGINE) can prevent depression in perinatal populations. The main questions it aims to answer are: Does IMAGINE engage cognitive behavioral therapy targets? Does IMAGINE lead to lower depression scores? Is IMAGINE acceptable, appropriate, usable and feasible? Participants will be randomized to either participate in an IMAGINE group for 12 weeks or receive standard of care. Participants will respond to questi... Read More
Gender:
FEMALE
Ages:
16 years and above
Trial Updated:
03/25/2025
Locations: Perinatal Support Washington, Seattle, Washington
Conditions: Depression During Pregnancy, Depression, Postpartum
Deep Brain Stimulation of Treatment-Resistant Bipolar Depression
Recruiting
This study is only enrolling at Baylor College of Medicine. The other research locations listed serve to support data analysis only. This research study is to investigate the use of technology called Deep Brain Stimulation (DBS) to potentially improve Treatment-Resistant Bipolar Depression (TRBD) symptoms in patients with severe cases. DBS involves the surgical implantation of leads and electrodes into specific areas of the brain, which are thought to influence the disease. A pack implanted in... Read More
Gender:
ALL
Ages:
Between 22 years and 64 years
Trial Updated:
01/14/2025
Locations: University of Washington, Seattle, Washington
Conditions: Bipolar Depression
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Seattle Neuropsychiatric Treatment Center, Seattle, Washington
Conditions: Treatment Resistant Depression
Lay-Delivered Behavioral Activation in Senior Centers
Recruiting
In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, the investigators have simplified Behavioral Activation to be delivered by lay volunteers ("Do More, Feel Better"; DMFB). The focus of Behavioral Activation is to guide clients to reengage in daily pleasant and rewarding activities, and reduce depressive symptoms. If the investigators can show that the lay delivery model has positive impact in comparison to M... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
10/10/2024
Locations: Greenwood Senior Center, Seattle, Washington +5 locations
Conditions: Depression
InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI
Recruiting
The purpose of this randomized controlled trial is to evaluate whether the InMotion intervention, delivered via telehealth (using a HIPAA-compliant video platform or phone), which uses evidence-based behavioral and motivational counseling to increase daily physical activity, is an effective treatment for Major Depressive Disorder (MDD) for people who are at least one year out from sustaining a traumatic brain injury (TBI). The first aim is to compare the efficacy of the InMotion intervention to... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/09/2024
Locations: University of Washington Medical Center, Seattle, Washington
Conditions: TBI (Traumatic Brain Injury), Depressive Disorder, Major, Clinical Depression, Mood Depressed, Physical Inactivity
Decision Making Tool for Firearm Storage
Recruiting
This is a one-arm pilot study testing the feasibility and acceptability of a decision aid about safe firearm storage.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/19/2024
Locations: University of Washington, Seattle, Washington
Conditions: Dementia, Mild, Depression
A Dyadic Approach to Perinatal Depression in Primary Care: Maternal Infant and Dyadic Care
Recruiting
The purpose of this study is to assess the effectiveness of a parenting intervention+usual care compared to usual care on postpartum depression and other mental health and parenting outcomes, as well as the feasibility and acceptability of the parenting intervention.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/18/2023
Locations: Amritha Bhat, Seattle, Washington
Conditions: Depression, Postpartum, Efficacy, Self, Anxiety