HeartStart HS1 Defibrillator* Event Registry
NCT04840797
Recruiting
A Prospective study on the performance and safety of the HeartStart OnSite (Model M5066A) \& HeartStart Home (Model M5068A) Defibrillator device data.
Gender:
ALL
Ages:
All
Trial Updated:
02/25/2025
Locations: Philips, Pittsburgh, Pennsylvania
Conditions: Sudden Cardiac Arrest
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Transdiagnostic Cognitive Biomarkers
NCT04864080
Recruiting
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depres... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Pain, Depression
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A Multi-Phase Study Examining Hospital to Home Transitions for Children With Medical Complexity
NCT04867395
Recruiting
The overarching objective of this study is to make it easier for parents of children with medical complexity (CMC) to take care of their children after discharge home from the hospital and reduce the chance of post-hospitalization morbidity (meaning bad outcomes such as readmissions) after discharge. CMC, or those with multiple chronic conditions, progressive conditions, or technology dependence, are at high risk for post-hospitalization morbidity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: NYU Langone Health, New York, New York
Conditions: Children With Medical Complexity (CMC)
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Longitudinal Study for Relapsing Polychondritis
NCT04919538
Recruiting
Relapsing polychondritis (RP) is a rare systemic inflammatory disease characterized by recurrent inflammation of cartilage including ears, nose, tracheobronchial tree, chest wall and joints. Less commonly, it can cause inflammation of eyes, vasculature, nervous system, skin and inner ear. The purpose of this study is to study the pathogenesis of RP.
Gender:
ALL
Ages:
All
Trial Updated:
02/25/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Relapsing Polychondritis, Vasculitis
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A Study of NB003 in Patients with Advanced Malignancies
NCT04936178
Recruiting
This a A Phase 1, Open-label, Multicenter Study to Assess the Safety, Tolerability, and Pharmacokinetics of NB003 in Subjects with Advanced Malignancies
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Standford University, Stanford, California +33 locations
Conditions: Advanced Solid Tumor
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Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer
NCT05020860
Recruiting
The purpose of this study is to learn whether clinical response (the amount a tumor shrinks based on imaging or tumor measurements obtained by physical exam) predicts pathologic response (the amount of tumor remaining when surgery is performed) in participants with breast cancer who are receiving chemotherapy prior to surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Harris Health System - Smith Clinic, Houston, Texas +1 locations
Conditions: Breast Cancer, Breast Neoplasm, Breast Cancer Female, Breast Cancer Invasive, Breast Cancer Stage II, Breast Cancer Stage III, Triple Negative Breast Cancer, Hormone Receptor-positive Breast Cancer, HER2-positive Breast Cancer, Triple Negative Breast Neoplasms, Estrogen Receptor-positive Breast Cancer
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CxBladder Surveillance of Intermediate and High-Risk Bladder Cancer Patients
NCT05080998
Recruiting
Surveillance for recurrence of urothelial carcinoma (UC) requires frequent cystoscopy, which is invasive, expensive and time-consuming. An accurate urinary biomarker has the potential to reduce the number of cystoscopies required during post-treatment surveillance. This is a prospective single arm multi-center study using the diagnostic CxBladder test with subjects previously diagnosed positive with primary or recurrent UC and who are undergoing a schedule of investigative cystoscopies and treat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Miami VA Healthcare System, Miami, Florida +6 locations
Conditions: Urothelial Bladder Cancer
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Promoting Recovery After STroke with Amantadine
NCT05140148
Recruiting
The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT). Patients will be randomized post-ischemic or hemorrhagic stroke either to the placebo arm or amantadine arm. Patients will be on study drug or placebo for 1 month but will be enrolled for 3 months total. At various time points patients will be examined and fill out questionnaires to determine level of stroke recovery.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/25/2025
Locations: The Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Stroke, Ischemic, Stroke Hemorrhagic
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Robotic Exoskeleton Gait Training in Adolescents with Cerebral Palsy
NCT05158218
Recruiting
The study design will consist of a cohort of adolescents and young adults with cerebral palsy (CP) that will undergo a gait training protocol. All participants will complete MEG baseline brain imaging measures of their sensorimotor cortical activity, MRI brain/spinal cord imaging (previous MRI or template brain may be substituted), neurophysiological tests of the spinal cord H-reflex, and a series of mobility clinical tests. After completing the baseline tests, the participants with CP will und... Read More
Gender:
ALL
Ages:
Between 14 years and 30 years
Trial Updated:
02/25/2025
Locations: Boys Town National Research Hospital, Boys Town, Nebraska
Conditions: Cerebral Palsy
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Restoring Empowerment and Choosing Hope (REACH)
NCT05299138
Recruiting
The goals of REACH are to help adults develop the skills they need to develop healthy relationship and marriage skills, improve ability to parent and co-parent effectively, identify and enhance skills and abilities required to gain or retain economic self-sufficiency, and foster family stability and increase successful marriage rates. Data from the tri-county region comprised of Sarasota, Manatee, and Charlotte counties demonstrates the presence of a number of risk factors affecting family stabi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Jewish Family and Children Service, Sarasota, Florida
Conditions: Intervention, Wait List Control
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Predictors of Behavioral Obesity Treatment Outcomes
NCT05326477
Recruiting
Socioceconomically disadvantaged individuals typically have poor outcomes in behavioral weight loss interventions, but the reasons for this are unknown. This project will characterize the mechanisms through which adverse daily experiences and present bias -- a cognitive adaptation to harsh and unpredictable environments -- account for disparities in weight loss outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Obesity
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Dental Block for Pain Relief in ED Dental Pain Patients
NCT05351099
Recruiting
This will be a prospective, observational cohort study assessing immediate pain relief from dental block in ED patients presenting with dental pain. The study will be conducted in the Community Regional Medical Center ED. The aim of this study, then, is to prospectively determine if dental block provides minimal clinically important difference in pain relief to these patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Community Regional Trauma and Burn Center, Fresno, California
Conditions: Dental Pain
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