Lymphatic System Stimulation in Heart Failure
NCT05834400
Recruiting
The goal of this pilot clinical trial is to obtain preliminary data on the effects of lymphatic exercise training in patients with heart failure. The main question\[s\] it aims to answer are: 1. Does performing lymphatic exercise decrease fluid overload symptoms (shortness of breath, lower legs swelling, fatigue), thoracic fluid content, and body fluid level? 2. Does performing lymphatic exercise improve sleep and quality of life (QOL)? Participants with heart failure will be randomly assigned... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2024
Locations: Cooper University Health Care (Cooper), Camden, New Jersey
Conditions: Heart Failure
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A Study of NOE-115 in Women With Vasomotor Symptoms Due to Menopause
NCT06385795
Recruiting
The purpose of this study is to determine the safety, tolerability, and preliminary effectiveness of NOE-115 on moderate to severe vasomotor symptoms (hot flashes) due to menopause in women.
Gender:
FEMALE
Ages:
Between 45 years and 60 years
Trial Updated:
10/24/2024
Locations: Noema PMM-201 Site #104, San Diego, California +4 locations
Conditions: Menopause Syndrome, Menopause, Hot Flashes
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Chemo-Immunotherapy Followed by Durvalumab and Ceralasertib in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer
NCT04699838
Recruiting
The primary objective of this single arm study is to estimate the progression free survival of previously-untreated patients with extensive stage small cell lung cancer. Patients will receive initial chemo-immunotherapy followed by maintenance therapy with durvalumab and oral ceralasertib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: University of Illinois Medical Center, Chicago, Illinois +4 locations
Conditions: Extensive Stage Small Cell Lung Cancer
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A Study of Enfortumab Vedotin in People with Urothelial Carcinoma of the Upper Urinary Tract
NCT05868265
Recruiting
The purpose of this study is to find out whether the study drug, enfortumab vedotin, is an effective and safe treatment for people who have urothelial carcinoma of the upper urinary tract. Study participants will be people who are not eligible to receive or have chosen not to receive the chemotherapy drug cisplatin for treatment of their cancer. In addition, all participants will be planning on having standard surgery to remove their tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Urothelial Carcinoma
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Phase 2 Study of KH001 in Long-term Relief from Dentin Hypersensitivity
NCT06464939
Recruiting
The purpose of this study is to evaluate the efficacy and safety of KH001 in subjects with dentin hypersensitivity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: ADA Forsyth, Cambridge, Massachusetts +1 locations
Conditions: Dentin Hypersensitivity
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A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma
NCT05028348
Recruiting
This phase 3 randomized, open-label multicenter trial will compare the efficacy, safety and the impact on health-related quality of life (HR-QoL) of SPd versus EloPd in pomalidomide-naïve patients with MM who have received 1 to 4 prior anti-MM regimens and been treated with an immunomodulatory imide drug (IMiD), proteasome inhibitor (PI) and an anti-CD38 monoclonal antibody (mAb).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: The University of Arizona Cancer Center, Tucson, Arizona +93 locations
Conditions: Multiple Myeloma
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A Study of Cardiovascular Disparities in the Greater Mankato Somali Community to Prevent Hypertension
NCT05873153
Recruiting
The purpose of this research is to develop ways to reduce hypertension-management-related disparities in the Greater Mankato Area Somali population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Erin Westfall, Mankato, Minnesota
Conditions: Hypertension
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Embo Registry; National Registry for Artery Embolization
NCT06477965
Recruiting
Embo Registry is a retrospective and prospective observational study to evaluate real world effectiveness and the use of Artery Embolization as a treatment for chronic pain with patients that have osteoarthritis and localized pain to provide symptomatic relief. This study is to determine the efficacy and validity of procedure and that following procedure patients had decreased pain and improved quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Vascular Solutions of North Carolina, Cary, North Carolina +1 locations
Conditions: Chronic Pain, Osteoarthritis, Knee, Osteoarthritis Thumb, Osteoarthritis Shoulder, Pain, Chronic, Tendonitis Elbow, Tendonitis Shoulder, Tendonitis;Achilles, Tenosynovitis
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Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer
NCT05034627
Recruiting
This phase I trial tests the safety, side effects, and best dose of calaspargase pegol-mknl in combination with cobimetinib in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced) or has spread to other places in the body (metastatic). Cobimetinib attacks a protein called MEK that has been known to stimulate cells that promote the growth of cancer cells in the body. Calaspargase pegol-mknl is an enzyme that converts the amino acid L-asparagi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: OHSU Knight Cancer Institute, Portland, Oregon
Conditions: Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8, Stage IIA Pancreatic Cancer AJCC v8, Stage IIB Pancreatic Cancer AJCC v8, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8
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A Novel, Regulated Gene Therapy (NGN-401) Study for Female Children with Rett Syndrome
NCT05898620
Recruiting
This study will evaluate the safety profile of the investigational gene therapy, NGN-401, in female children with typical Rett syndrome.
Gender:
FEMALE
Ages:
Between 4 years and 10 years
Trial Updated:
10/24/2024
Locations: Children's Hospital Colorado, Aurora, Colorado +7 locations
Conditions: Rett Syndrome
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Enhancing Motivation to Quit Smoking Via Self-Help Intervention Targeted to Cancer Type
NCT06484179
Recruiting
The purpose of this research study is assess feasibility and acceptability of a recently developed brief self-help intervention targeted by cancer type to increase motivation to quit smoking.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Huntsman Cancer Institute, Salt Lake City, Utah
Conditions: Cancer, Smoking
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Developing a Clinical Outcome Assessment for Opioid Craving
NCT05109429
Recruiting
The purpose of this study is to collect information about opioid craving so that the investigators can develop an opioid craving assessment to improve treatments for individuals with opioid use disorder. To collect this information, the investigators are recruiting individuals in treatment for opioid use disorder who will complete cue-induced opioid craving tasks where these individuals will: (1) look at pictures of neutral objects and touch neutral objects (e.g., water bottles or flashlights),... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Opioid Craving, Opioid Use Disorder, Measure Development
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