Chemo-Immunotherapy Followed by Durvalumab and Ceralasertib in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer
NCT04699838
Recruiting
The primary objective of this single arm study is to estimate the progression free survival of previously-untreated patients with extensive stage small cell lung cancer. Patients will receive initial chemo-immunotherapy followed by maintenance therapy with durvalumab and oral ceralasertib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: University of Illinois Medical Center, Chicago, Illinois +4 locations
Conditions: Extensive Stage Small Cell Lung Cancer
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FMT in Uncomplicated Diverticulitis
NCT05373784
Recruiting
Fecal Microbiota Transplantation (FMT) is an established treatment for Clostridium difficile (C. diff) infection refractory to medical management. As C. diff infection usually arises due to significant disturbances in the gut microbiome, FMT is typically performed to restore a healthy microbiome among affected patients who have failed other treatments. Diverticulitis is a major, and often recurrent, source of morbidity in the U.S for which antibiotics and surgical resection constitute the only t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: UMASS Memorial Medical Center, Worcester, Massachusetts
Conditions: Diverticulitis, Uncomplicated Diverticular Disease
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A Study of Enfortumab Vedotin in People with Urothelial Carcinoma of the Upper Urinary Tract
NCT05868265
Recruiting
The purpose of this study is to find out whether the study drug, enfortumab vedotin, is an effective and safe treatment for people who have urothelial carcinoma of the upper urinary tract. Study participants will be people who are not eligible to receive or have chosen not to receive the chemotherapy drug cisplatin for treatment of their cancer. In addition, all participants will be planning on having standard surgery to remove their tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Urothelial Carcinoma
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Study of 18F-FFNP Breast PET/MRI
NCT06086704
Recruiting
This clinical trial will investigate an estrogen-regulated parameter as an early measure of endocrine therapy response: progesterone receptor (PR) protein with a progestin-based radioligand, 18F-fluorofuranylnorprogesterone (18F-FFNP). The overall purpose of this research is to test the efficacy of 18F-FFNP PET/MRI for predicting response to presurgical endocrine therapy and to determine the quantitative reliability of 18F-FFNP breast PET/MRI in patients with newly diagnosed PR+ primary breast c... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: UW Carbone Cancer Center, Madison, Wisconsin
Conditions: Breast Cancer
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Phase 2 Study of KH001 in Long-term Relief from Dentin Hypersensitivity
NCT06464939
Recruiting
The purpose of this study is to evaluate the efficacy and safety of KH001 in subjects with dentin hypersensitivity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: ADA Forsyth, Cambridge, Massachusetts +1 locations
Conditions: Dentin Hypersensitivity
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Longitudinal Study of Neurogenetic Disorders
NCT03492060
Recruiting
The purpose of this study is to analyze patterns in individuals with hnRNP (and other) genetic variants, including their neurological comorbidities, other medical problems and any treatment. The investigators will maintain an ongoing database of medical data that is otherwise being collected for routine medical care. The investigators will also collect data prospectively in the form of questionnaires, neuropsychological assessments, motor assessments, and electroencephalography to examine the la... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/24/2024
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Neurodevelopmental Disorders, Intellectual Disability, Developmental Delay, Autism Spectrum Disorder, Seizures, Hypertonia, Muscle, Hypotonia
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A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma
NCT05028348
Recruiting
This phase 3 randomized, open-label multicenter trial will compare the efficacy, safety and the impact on health-related quality of life (HR-QoL) of SPd versus EloPd in pomalidomide-naïve patients with MM who have received 1 to 4 prior anti-MM regimens and been treated with an immunomodulatory imide drug (IMiD), proteasome inhibitor (PI) and an anti-CD38 monoclonal antibody (mAb).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: The University of Arizona Cancer Center, Tucson, Arizona +93 locations
Conditions: Multiple Myeloma
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Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects
NCT05476497
Recruiting
This phase I clinical trial is designed to evaluate the safety and tolerability of VLP Peanut in healthy subjects and in subjects with peanut allergy (PA). This clinical trial will evaluate the immunotoxicity profile of VLP Peanut in healthy subjects and assess the immunotoxicity profile and the degree of reactogenicity (allergenicity) in subjects with PA. This clinical trial will also explore preliminary proof of efficacy of VLP Peanut in subjects with PA.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
10/24/2024
Locations: University of Arizona, Tucson, Arizona +9 locations
Conditions: Peanut Allergy
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A Study of Cardiovascular Disparities in the Greater Mankato Somali Community to Prevent Hypertension
NCT05873153
Recruiting
The purpose of this research is to develop ways to reduce hypertension-management-related disparities in the Greater Mankato Area Somali population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Erin Westfall, Mankato, Minnesota
Conditions: Hypertension
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An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder
NCT06102200
Recruiting
The Overcome II study is a randomized controlled trial among adults receiving sublingual buprenorphine to help prevent or reduce illicit drug use. The study outcomes will be compared between three treatment arms: (1) sublingual buprenorphine only, which is the standard-of-treatment (2) sublingual buprenorphine with a computer-based cognitive behavior therapy for substance use disorders (CBT4CBT), (3) sublingual buprenorphine with CBT4CBT and peer recovery coaching. The primary outcome of interes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Greenville Health System, Greenville, South Carolina
Conditions: Standard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RC
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Embo Registry; National Registry for Artery Embolization
NCT06477965
Recruiting
Embo Registry is a retrospective and prospective observational study to evaluate real world effectiveness and the use of Artery Embolization as a treatment for chronic pain with patients that have osteoarthritis and localized pain to provide symptomatic relief. This study is to determine the efficacy and validity of procedure and that following procedure patients had decreased pain and improved quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Vascular Solutions of North Carolina, Cary, North Carolina +1 locations
Conditions: Chronic Pain, Osteoarthritis, Knee, Osteoarthritis Thumb, Osteoarthritis Shoulder, Pain, Chronic, Tendonitis Elbow, Tendonitis Shoulder, Tendonitis;Achilles, Tenosynovitis
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Methylphenidate and Exercise in Reducing Cancer-Related Fatigue in Patients with Prostate Cancer
NCT03772834
Recruiting
This phase II/III trial studies how well methylphenidate and exercise work in reducing cancer-related fatigue in patients with prostate cancer. Methylphenidate is a type of central nervous system stimulant that can improve cognitive ability, mainly in memory and cognitive function. Exercise can improve mood and the physical aspects of cancer-related fatigue. Giving methylphenidate in combination with exercise may work better in reducing cancer-related fatigue in patients with prostate cancer.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Prostate Carcinoma
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