The Effect of General Anesthesia on Pharmacokinetics of Oxycodone in Pediatric
NCT03054831
Recruiting
Oxycodone is an oral opioid analgesic that is most commonly prescribed for the management of pain in post-operative patients at Boston Children's Hospital. Oxycodone has been widely used in adults and children to relieve post-operative pain. However, its pharmacokinetics (what it does in the body) and pharmacodynamics (how it works) have not been well established in children. Some children, because of their specific genetic make-up, may metabolize the drug more quickly and therefore may be at ri... Read More
Gender:
ALL
Ages:
Between 2 years and 8 years
Trial Updated:
02/12/2025
Locations: Boston Children Hospital, Boston, Massachusetts
Conditions: Liquid Oxycodone
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18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma
NCT03541720
Recruiting
PET (positron emission tomography) scans combined with a radioactive tracer will be used to identify and analyze tumors. Currently, the most common tracer used to analyze neuroblastoma tumors is called 123I-mIBG. However, the picture it provides is not always clear enough to see the very small areas of the disease. 18F-DA (18F-fluorodopamine) has been shown to be safe and more effective than 123I-mIBG in analyzing the tumor pheochromocytoma, which is closely related to neuroblastoma. With this... Read More
Gender:
ALL
Ages:
1 year and above
Trial Updated:
02/12/2025
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Neuroblastoma, Pheochromocytoma
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Stanford Regulating Circuits of the Brain Study - MDMA
NCT04060108
Recruiting
This study is a biomarker study designed to characterize how human neural circuits and behaviors are modified during altered states induced by MDMA.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
02/12/2025
Locations: Stanford Psychiatry and Behavioral Sciences Department, Palo Alto, California
Conditions: Healthy
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A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
NCT04094610
Recruiting
Phase 1 will evaluate the safety and tolerability at different dose levels of repotrectinib in pediatric and young adult subjects with advanced or metastatic malignancies harboring anaplastic lymphoma kinase (ALK), receptor tyrosine kinase encoded by the gene ROS1 (ROS1), or neurotrophic receptor kinase genes encoding TRK kinase family (NTRK1-3) alterations to estimate the Maximum Tolerated Dose (MTD) or Maximum Administered Dose (MAD) and select the Pediatric Recommended Phase 2 Dose (RP2D). P... Read More
Gender:
ALL
Ages:
25 years and below
Trial Updated:
02/12/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California +67 locations
Conditions: Locally Advanced Solid Tumors, Metastatic Solid Tumors, Lymphoma, Primary CNS Tumors
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Impact of Tamsulosin on Post-Operative Urinary Retention Following Pelvic Reconstructive Surgery
NCT04597372
Recruiting
The objective of the study is to determine the effectiveness of postoperative Tamsulosin in reducing the duration of acute postoperative urinary retention (POUR) following pelvic reconstructive surgery through a double blind, randomized placebo-controlled trial.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/12/2025
Locations: West Penn Hospital, Pittsburgh, Pennsylvania
Conditions: Urinary Retention Postoperative
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Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures
NCT04604418
Recruiting
The incidence of moderate to severe congenital heart disease (CHD) in the United States is estimated to be 6 per 1000 live-born full term infants. Recent advances in pediatric cardiology, surgery and critical care have significantly improved the survival rates of patients with CHD leading to an increase in prevalence in both children and adults. Children with CHD significant enough to require cardiac surgery frequently also undergo non-cardiac surgical procedures. Analysis of the Pediatric Healt... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
02/12/2025
Locations: University of California, Los Angeles, Los Angeles, California +9 locations
Conditions: Congenital Heart Disease in Children
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Positioning for Hip Arthroscopic Surgery to Reduce Postoperative Numbness
NCT05038709
Recruiting
Compared to the knee and shoulder, the hip joint leaves relatively little space to maneuver arthroscopic instruments and camera. To expand the potential space in the hip joint, traction is commonly applied to the operative leg through a perineal post. This is an effective technique to improve the working space for arthroscopy, however it has been associated with complications, including perineal numbness. Traction pads, used alone or with a perineal post, can reduce pressure on the perineal area... Read More
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
02/12/2025
Locations: Northwestern University Department of Orthopaedic Surgery, Chicago, Illinois
Conditions: Hip Osteoarthritis, Hip Injuries, Hip Sprain, Hip Strain
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Monitoring for Cancer Spread to the Central Nervous System (CNS) in People With Breast Cancer
NCT05130840
Recruiting
The researchers doing this study think that performing scans of the brain and testing cerebrospinal fluid (CSF) in people with HER2-positive breast cancer may be an effective way of identifying the early onset of CNS metastases (such as brain cancer). If the researchers can identify the early onset of CNS metastases, they can immediately treat that cancer and possibly prevent it from worsening. Currently, people with breast cancer don't usually have scans of the brain or CSF testing unless they... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/12/2025
Locations: Memorial Sloan Kettering Cancer Center, New York, New York
Conditions: Breast Cancer
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Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients with Bipolar Depression
NCT05240352
Recruiting
The purpose of this study is to investigate whether transcranial direct-current stimulation (tDCS) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) regions. Also to evaluate whether the changes in the fractional anisotropy (FA) of the UF tract are associated with changes of clinical symptoms of anhedonia and finally to investigate the moderation role of simulated electric f... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
02/12/2025
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Anhedonia
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Efficacy of RestoreX Penile Traction Therapy In Preserving Erectile Function Post-Prostatectomy
NCT05244486
Recruiting
Evaluate the efficacy of the RestoreX penile traction device in preserving erectile function in men undergoing robotic-assisted prostatectomy. This study will evaluate men undergoing prostatectomy with bilateral nerve preservation and preserved baseline erectile function (moderate ED or better). The primary outcome will be changes in the IIEF-EFD scores between groups at 6 months. Secondary outcomes include differences in questionnaire outcomes at 3, 6, and 9 months.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/12/2025
Locations: The Male Fertility and Peyronie's Clinic, Orem, Utah
Conditions: Erectile Dysfunction Following Radical Prostatectomy
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PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age with Scabies
NCT05310734
Recruiting
A population of approximately 50 pediatric subjects will be enrolled to assess the PK of spinosad and benzyl alcohol for 3 hours following a single, full-body topical application (open label) on a single in-clinic visit (Day 1, or Day 2 if screening only on Day 1). There will be approximately 50 subjects ages 1 month to 3 years 11 months of age enrolled with the goal of completing approximately 16 subjects. With assistance from a caregiver, Natroba will be applied over the entire body from the n... Read More
Gender:
ALL
Ages:
Between 1 month and 4 years
Trial Updated:
02/12/2025
Locations: L&C Professional Medical Research Institute, Miami, Florida +2 locations
Conditions: Scabies
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Trial to Evaluate Fecobionics in Fecal Incontinence (FI) (NORMAL and ABNORMAL-FI)
NCT05412069
Recruiting
The objective is to determine the length-tension properties of the anal sphincters using Fecobionics in normal subjects and FI patients during anal distension and during simulated evacuation. Fecobionics has the consistency and shape of normal stool and can record pressures, cross-sectional area, orientation and viscoelastic properties of the anorectum and can map the geometric profiles during evacuation, and thereby provides multi-dimensional measurements of pressures, deformability, and topogr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/12/2025
Locations: California Medical Innovations Institute, San Diego, California +1 locations
Conditions: Normal Subjects, Fecal Incontinence
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