Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
NCT03970343
Recruiting
The OPTIMIZER Smart Post-Approval Study is a prospective, multi-center, non-randomized, single arm open label study of 620 subjects receiving an OPTIMIZER implant as standard of care. Patients to be included will have NYHA functional class III symptoms and a left ventricular ejection fraction of 25-45%
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: CardioVascular Associates of Mesa (CVAM), Mesa, Arizona +92 locations
Conditions: Heart Failure
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Healthy Living After Knee Replacement
NCT05190666
Recruiting
The purpose of this study is to examine if a weight loss program designed for adults after knee replacement improves weight loss, physical activity, pain, and function, as well as if the program is cost effective, as compared to a chronic disease self-management program.
Gender:
ALL
Ages:
All
Trial Updated:
10/09/2024
Locations: University of South Carolina, Columbia, South Carolina
Conditions: Arthroplasty, Overweight and Obesity
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Intrathecal Dexmedetomidine Vs Epinephrine
NCT06418308
Recruiting
Several studies have shown that adding dexmedetomidine or epinephrine to single-dose spinal analgesia preparations improves the length and/or speed of onset of the sensory block and post-operative pain management without increased negative side effects. To date, however, no study has compared adjunctive intrathecal dexmedetomidine to adjunctive intrathecal epinephrine in single-dose spinal analgesia. The purpose of this study is to determine if adjunctive intrathecal dexmedetomidine is non-infer... Read More
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
10/09/2024
Locations: Mount Sinai Hospital, New York, New York
Conditions: Cesarean Section, Anesthesia, Spinal
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Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension
NCT04039464
Recruiting
The investigators' central hypothesis is that early combination therapy with two PAH-specific oral therapies that have been shown to be well tolerated in the pediatric population, sildenafil and bosentan, will result in better World Health Organization (WHO) functional class at 12 months after initiation of PAH treatment than therapy with sildenafil alone.
Gender:
ALL
Ages:
Between 3 months and 18 years
Trial Updated:
10/09/2024
Locations: The Regents of the University of California, San Francisco, San Francisco, California +13 locations
Conditions: Pediatric Pulmonary Hypertension
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AOH1996 for the Treatment of Refractory Solid Tumors
NCT05227326
Recruiting
This phase I trial studies the side effects and best dose of AOH1996 in treating patients with solid tumors that do not respond to treatment (refractory). AOH1996 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: Honor Health Research and Innovation Institute, Scottsdale, Arizona +1 locations
Conditions: Refractory Malignant Solid Neoplasm, Osteosarcoma, Leiomyosarcomas, Synovial Sarcomas, Ovarian Cancer, Non-Small Cell Lung Cancer, Pancreatic Cancer
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Optimal Pacing Rate for Cardiac Resynchronization Therapy
NCT06445439
Recruiting
This is a prospective, randomized crossover study. The objective of the study is to determine if a pacing rate of 80 beats per minute (bpm) improves exercise tolerance during the 6-minute walk test. The investigators will randomly assign half of the participants to a starting rate of 60 bpm and then switch them to a rate of 80 bpm for 3 months, and vice versa.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/09/2024
Locations: MedStar Georgetown University Hospital, Washington, District of Columbia +4 locations
Conditions: Atrial Fibrillation, Persistent
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Natural History Study of Infantile and Juvenile GM1 Gangliosidosis (GM1) Patients
NCT04041102
Recruiting
Owing to the rarity, severity, speed of progression and fatal prognosis of infantile and juvenile GM1, there is a limited understanding of overall disease progression and meaningful outcome measures. This study aims to build a natural history data set through collection of a number of clinical, imaging, and laboratory assessments that may be specific predictors of GM1 disease progression and clinical outcome. Having a GM1 natural history data set can inform potential efficacy endpoints and bioma... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/09/2024
Locations: UCSF Benioff Children's Hospital Oakland, Oakland, California +5 locations
Conditions: GM1 Gangliosidosis
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How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD
NCT05359562
Recruiting
Studies show that hormones affect the brain's fear extinction network, which is relevant for therapy involving exposure and response prevention (EX/RP), a first-line treatment for obsessive compulsive disorder (OCD). This study will examine the effect of delivering EX/RP to women during different phases in their menstrual cycle to determine the effects of hormones on the fear extinction network and on their OCD symptoms.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
10/09/2024
Locations: New York State Psychiatric Institute, New York, New York +1 locations
Conditions: OCD
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Impact of Intraoperative ICG on Functional Outc in RARP
NCT06446648
Recruiting
This is a pilot, 3 phases open-label feasibility study with the 3rd phase consisting of randomized 2-arm intervention trial, to assess the systematic use of indocyanine green (ICG) in subjects with prostate adenocarcinoma during robot-assisted radical prostatectomy and its impact on sexual function outcomes at 12 months postoperatively.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: Chao Family Comprehensive Cancer Center University of California, Irvine, Orange, California
Conditions: Prostate Adenocarcinoma
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Perioperative Mindfulness Proposal
NCT04049214
Recruiting
The purpose of this study is to determine if a regular meditation and breath work practice started before surgery and continued through post-surgical recovery can improve anxiety and pain related to breast cancer and its treatment.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Breast Cancer, DCIS
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CPAP for the Treatment of Supine Hypertension
NCT05489575
Recruiting
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment for sleep apnea) involves using a machine that blows air into a tube connected to a mask covering the nose, or nose and mouth, to apply a low air pressure in the airways. The study includes 3-5 days sp... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
10/09/2024
Locations: Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease, Supine Hypertension, Neurogenic Orthostatic Hypotension
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Blood Flow Restriction Training on Upper Extremity Grip Strength
NCT06535373
Recruiting
The primary objective of this prospective study is to investigate the effects of Blood Flow Restriction (BFR) training compared to traditional low-weight resistance training on grip strength in young adults. Despite the growing interest in BFR training and its potential benefits, there is limited research specifically investigating its impact on grip strength. Understanding the effects of BFR training on grip strength could have significant implications for individuals seeking to optimize their... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
10/09/2024
Locations: Casa Colina Healthcare and Hospital, Pomona, California
Conditions: Healthy Volunteers
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