Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial
Recruiting
The goal of this randomized crossover trial is to compare the differences in psychological and physiological effects of walking in two different outdoor environments (urban/suburban commercial environments vs. urban/suburban nature areas/preserves) in adults with prediabetes. The main questions it aims to answer are: * Do psychological measures of stress, anxiety, and affect improve more in one type of outdoor environment over the other? * Do physiological measures of stress improve more in one... Read More
Gender:
ALL
Ages:
Between 25 years and 64 years
Trial Updated:
08/18/2025
Locations: Lake Forest Hospital, Lake Forest, Illinois +1 locations
Conditions: PreDiabetes, Heart Rate Variability (HRV), Stress and Anxiety, Stress Biomarkers
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
Recruiting
BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects with moderate-to-severe ARDS (P/F ratio ≤150) due to pneumonia or other infections. Potential subjects hospitalized with pneumonia or other infections are to be screened within 24 hours of diagnosis of ARDS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/17/2025
Locations: University of California Irvine Medical Center, Irvine, California +66 locations
Conditions: Acute Respiratory Distress Syndrome, Infections
Phase 2 Study to Assess the Safety, PK, and PD of Sonefpeglutide (HM15912) in SBS-IF Subjects
Recruiting
This is a randomized, double-blind, placebo-controlled, proof-of-concept (PoC), Phase 2 study to assess the safety, PK, and PD of SC administration of HM15912(sonefpeglutide) in adult subjects with SBS-associated intestinal failure (SBS-IF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/17/2025
Locations: University of Illinois Hospital & Health Sciences System (UI Health), Chicago, Illinois +13 locations
Conditions: Short Bowel Syndrome
Immunology of Ebola Vaccine
Recruiting
In this study 30 healthy adult participants will receive a single dose of an Ebola vaccine. Blood samples, fine needle aspirates, core biopsies, and bone marrow aspirates will be collected prior to and following vaccination to assess immune responses in the blood, lymph nodes, and bone marrow over multiple time points.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/17/2025
Locations: The Hope Clinic of the Emory Vaccine Center, Decatur, Georgia +1 locations
Conditions: Ebola Virus Disease
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor
Recruiting
This is an open-label phase 1 study with an escalation part and an expansion part.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/17/2025
Locations: Mayo Clinic, Jacksonville, Florida +30 locations
Conditions: Advanced Liver Cancer
Tranexamic Acid in Nasal Mohs Reconstruction
Recruiting
This study will be a prospective randomized control trial to evaluate the effects of subcutaneously administered TXA among patients undergoing nasal Mohs reconstruction with local flaps at VUMC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/17/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Postoperative Bleeding, Skin Cancer Face
RECOVER-ENERGIZE Platform Protocol
Recruiting
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management programs and treatment plans if results achieve key study outcomes. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating interventions to address and improve exercise intolerance and post-exertional malaise (PEM) as ma... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +41 locations
Conditions: Long COVID, Long Covid19, Long Covid-19
Exploring the Potential of Robotic Telesurgery in Remote Settings
Recruiting
This study involves a type of robotic surgery called telesurgery, where a highly trained surgeon performs the surgical procedure using a secure internet connection to operate on a patient in a different location. Urologists from The goal of this study is to find out how safe and effective telesurgery is when used in real hospitals. The study aims to understand how well Telesurgery works in different settings, what technical challenges might come up (like internet speed or delays), and how it can... Read More
Gender:
MALE
Ages:
Between 18 years and 90 years
Trial Updated:
08/16/2025
Locations: AdventHealth, Celebration, Florida
Conditions: Prostate Carcinoma, Prostate Disease
RECOVER-SLEEP: Platform Protocol
Recruiting
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple interventions and allows comparative analysis across the interventions. For example, objectives, measures, and endpoints are generalized in the platform protocol, but intervention-specific features are detailed in separate appendices. This platform protocol is a prospect... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2025
Locations: Banner University Medical Center Phoenix, Phoenix, Arizona +46 locations
Conditions: Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
Evaluating the Dose, Safety, Tolerability, and Immunogenicity of Mosaic Hexavalent Influenza Vaccine VRCFLUMOS0116-00-VP (FluMos-v2) With and Without ALFQ Adjuvant in Healthy Adults
Recruiting
Background: Vaccines help the body learn to fight infections. Some vaccines are combined with adjuvants, which are added substances that make vaccines work better. FluMos-v2 is an experimental flu vaccine; ALFQ is an experimental adjuvant. Objective: To test FluMos-v2, with and without the ALFQ adjuvant, in healthy adults. Eligibility: Healthy adults aged 18 to 50 years. They must have received at least one flu vaccine from the 2020-21 season through the 2023-24 flu season. They must also a... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/16/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Influenza Prevention, Seasonal Influenza
Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy
Recruiting
This phase I trial tests the safety, side effects, best dose, and effectiveness of emavusertib (CA-4948) in combination with pembrolizumab in treating patients with urothelial cancer that has spread from where it first started to other places in the body (metastatic) and that has a resistance to PD-1/PD-L1 immune checkpoint inhibitors. CA-4948, a kinase inhibitor, may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2025
Locations: City of Hope Comprehensive Cancer Center, Duarte, California +4 locations
Conditions: Metastatic Urothelial Carcinoma, Unresectable Urothelial Carcinoma
Abbott Cephea Mitral Valve Disease Registry
Recruiting
The objective of this registry is to gather clinical data on symptomatic patients with mitral valve disease, including patients with mitral regurgitation, mitral stenosis, and mixed mitral valve disease. Data collected from this registry are expected to improve our understanding of the impact of correcting symptomatic mitral valve disease on clinical outcomes in patients that could be candidates for Transcatheter Mitral Valve Replacement and may also inform future regulatory or reimbursement sub... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/16/2025
Locations: Via Christi Regional Medical Center - St. Francis Campus, Wichita, Kansas
Conditions: Mitral Regurgitation, Mitral Stenosis, Mitral Valve Disease, Mitral Valve (MV) Regurgitation, Mitral Annulus Calcification, Mitral Valve Replacement, Transcatheter Valve Replacement