Evaluation of the Protective Efficacy of TV003 or Previous Zika Infection Against Infection With ZIKV-SJRP Challenge Compared to DENV and ZIKV-naïve Controls Against Infection With ZIKV-SJRP Challenge
Recruiting
Zika virus (ZIKV) is an illness people can get from mosquitoes. The infection is generally mild with symptoms that include a fever, rash, red eyes, and joint pain, though most of those infected have no symptoms. Preventing ZIKV is important because if a pregnant person is infected with ZIKV, it can cause birth defects in their unborn child. The goals of this study are to find out if people who have already been infected with one type of ZIKV can get infected with ZIKV a second time, and to test... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
01/28/2025
Locations: Center for Immunization Research, Johns Hopkins School of Public Health, Baltimore, Maryland +1 locations
Conditions: Zika Virus
Get With the Guidelines-Stroke Registry
Recruiting
Get With The Guidelines-Stroke is a program for improving the quality of care for patients hospitalized with stroke by promoting consistent adherence to the latest evidence-based clinical practice guidelines.
Gender:
ALL
Ages:
Between 18 years and 125 years
Trial Updated:
01/27/2025
Locations: Amy Bennett, Dallas, Texas
Conditions: Stroke
Get With The Guidelines-Heart Failure Registry
Recruiting
Get With The Guidelines-Heart Failure is designed to improve the quality of care in patients hospitalized with heart failure. The program aims to help ensure that eligible patients are initiated on guideline recommended therapies and receive appropriate counseling prior to hospital discharge.
Gender:
ALL
Ages:
Between 18 years and 125 years
Trial Updated:
01/27/2025
Locations: Amy Bennett, Dallas, Texas
Conditions: Heart Failure
Collection and Measurement of Biomarkers in Prostate Cancer Radiotherapy Patients
Recruiting
The purpose of this research study is to learn about: 1) How standard radiation treatment to prostate (primary radiotherapy) or the pelvis after prostatectomy (postoperative radiotherapy) may cause changes in MRI and PET imaging traits that might be used in the future to predict response. 2) Comparison of such MRI and PET imaging traits with the number of circulating tumor cells (CTCs) present in the blood prior to treatment and the changes in these counts after treatment. 3) How MRI and PET ima... Read More
Gender:
MALE
Ages:
30 years and above
Trial Updated:
01/27/2025
Locations: University of Miami, Miami, Florida
Conditions: Prostate Cancer
Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors
Recruiting
First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/27/2025
Locations: Moffitt Cancer Center, Tampa, Florida +12 locations
Conditions: Malignant Peripheral Nerve Sheath Tumors
Fecal Microbiota Transplant National Registry
Recruiting
A national data registry of patients receiving fecal microbiota transplantation (FMT) or other gut-related-microbiota products designed to prospectively assess short and long-term safety and effectiveness
Gender:
ALL
Ages:
All
Trial Updated:
01/27/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +49 locations
Conditions: Fecal Microbiota Transplantation, Clostridium Difficile Infection, Gut Microbiome
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Recruiting
This is a Phase 1/2 open-label, multi-center, multi-national study with an initial dose escalation part to determine the recommended Phase II dose (RP2D) of MCLA-158 single agent in patients with mCRC. The dose escalation part has been completed and the RP2D will be further evaluated in an expansion part of the study. Cohorts of selected solid tumor indications for which there is evidence of EGFR dependency and potential sensitivity to EGFR inhibition will be evaluated including head and neck c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/27/2025
Locations: UCSD, La Jolla, California +44 locations
Conditions: Advanced/Metastatic Solid Tumors, Colorectal Cancer, Gastric Cancer, Gastroesophageal-junction Cancer, NSCLC, HNSCC, Head and Neck Squamous Cell Carcinoma, Esophageal Cancer
Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma
Recruiting
This research study is studying an immunotherapy drug (pembrolizumab or KEYTRUDA) as a possible treatment for pediatric hepatocellular carcinoma or hepatocellular neoplasm not otherwise specified (HCN NOS).
Gender:
ALL
Ages:
Between 0 years and 30 years
Trial Updated:
01/27/2025
Locations: University of California San Francisco, San Francisco, California +4 locations
Conditions: Hepatocellular Carcinoma, Childhood, Liver Cancer, Fibrolamellar Carcinoma, Liver Cancer, Pediatric
Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
Recruiting
The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/27/2025
Locations: Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology, Augusta, Georgia
Conditions: Type 1 Diabetes
Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
Recruiting
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin (naturally occurring hormone that is made in the brain). In this study healthy volunteers and people with knee arthritis so severe that they may need joint replacement are recruited for a one day study. Each study participant will have an IV catheter placed. After placement of the IV catheter oxytocin will be given by IV infusion. Investigators will perform some tests to evaluate how oxytocin changes perc... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/27/2025
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Osteoarthritis, Knee
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
Recruiting
This prospective study is a multi-center early feasibility study assessing the safety and performance of the Aria CV Pulmonary Hypertension System in patients with pulmonary hypertension and right heart dysfunction.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/27/2025
Locations: University of California - San Diego, La Jolla, California +11 locations
Conditions: Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
Avo In R/R And Previously Untreated MCL
Recruiting
This research study is evaluating the combination of three drugs - acalabrutinib, venetoclax, and obinutuzumab - as a possible treatment for relapsed or refractory and untreated mantle cell lymphoma (MCL). The names of the study drugs involved in this study are: * Acalabrutinib * Venetoclax * Obinutuzumab
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/27/2025
Locations: University of Chicago Medical Center, Chicago, Illinois +2 locations
Conditions: Mantle Cell Lymphoma, Refractory Lymphoma