Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body
NCT06470243
Recruiting
This phase III trial compares the effect of adding carboplatin to the standard of care chemotherapy drug cabazitaxel versus cabazitaxel alone in treating prostate cancer that keeps growing even when the amount of testosterone in the body is reduced to very low levels (castrate-resistant) and that has spread from where it first started (primary site) to other places in the body (metastatic). Carboplatin is in a class of medications known as platinum-containing compounds. Carboplatin works by kill... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Highlands Oncology Group - Fayetteville, Fayetteville, Arkansas +173 locations
Conditions: Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
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Perioperative Fostamatinib With Gemcitabine and Nab-paclitaxel in Resectable Pancreatic Cancer
NCT06639724
Recruiting
This is a Phase 1b trial evaluating the combination of Fostamatinib, a Syk kinase inhibitor currently FDA-approved for chronic idiopathic thrombocytopenia purpura (ITP), with the standard of care chemotherapy agents gemcitabine and nab-paclitaxel, for the perioperative treatment of resectable non metastatic pancreatic ductal adenocarcinoma (PDAC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: University of California, San Diego Moores Cancer Center, La Jolla, California
Conditions: Pancreatic Ductal Adenocarcinoma (PDAC)
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A 12-week Pilot Nutrition Intervention for Children With New Diagnosis of Stage 3 Type 1 Diabetes (T1D)
NCT06640478
Recruiting
The purpose of this research study is to investigate the effects of a combination of weekly distribution of healthy foods and intensive nutrition counseling as complementary therapies to the standard insulin therapy in children with new diagnosis of stage 3 type 1 diabetes (T1D). Feasibility, acceptability, and fidelity of this intervention will be measured. We will also explore the likelihood of prolonging the honeymoon phase of T1D in the intervention study group. Comparisons will be made betw... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
12/20/2024
Locations: Penn State Health Children's, Hershey, Pennsylvania +1 locations
Conditions: Type 1 Diabetes
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Study to Test the Combination of Fulvestrant With Lu-DOTATATE for Advanced Pancreatic Neuroendocrine Tumors
NCT06663072
Recruiting
This is a phase I, open-label study to assess the safety and preliminary efficacy of Fulvestrant in combination with 177Lu-DOTATATE for advanced pNETs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois
Conditions: Metastatic Pancreatic Neuroendocrine Tumor
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Longitudinal Tumor Burden Quantification Using Circulating Tumor DNA in Metastatic Lobular Breast Cancer
NCT06666439
Recruiting
The goal of this study is to characterize early dynamic changes in ctDNA, which can aid in tailoring early therapy in patients with metastatic Invasive lobular carcinoma (ILC). Response assessment using ctDNA analysis could not only aid in de-escalation but also escalation strategies.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Magee Women's Hospital of UPMC, Pittsburgh, Pennsylvania
Conditions: Metastatic Invasive Lobular Carcinoma (mILC)
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Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs
NCT06674980
Recruiting
The purpose of the study is to evaluate the efficacy of multiple human placental membrane products and Standard of Care (SOC) versus SOC alone in the management of nonhealing diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) over 12 weeks using a modified platform trial design.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Poirot Podiatry, Metairie, Louisiana
Conditions: Pathologic Processes, Diabetes Mellitus, Glucose Metabolism Disorders, Metabolic Diseases, Endocrine System Disease, Diabetic Angiopathies, Vascular Diseases, Cardiovascular Diseases, Leg Ulcer, Skin Ulcer, Skin Diseases, Diabetes Complications, Diabetic Neuropathies, Foot Diseases, Diabetic Foot, Foot Ulcer, Diabetes Mellitus, Type 2, Ulcer, Foot Ulcer Unhealed
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High Risk Breast Clinic: Protocol for Women at Increased Risk for Developing Breast Cancer
NCT00291096
Recruiting
The overall goal of this project is to develop an integrative system of breast cancer risk assessment based on epidemiologic and biologic risk variables, as well as to develop or refine risk biomarkers which may be useful in predicting and monitoring response to prevention interventions.
Gender:
FEMALE
Ages:
Between 30 years and 65 years
Trial Updated:
12/19/2024
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Breast Cancer
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The Longevity Genes in Founder Populations Project
NCT00707694
Recruiting
We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of our research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/19/2024
Locations: Private Homes, New York, New York +1 locations
Conditions: Extreme Longevity
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Islet Transplantation in Patients With "Brittle" Type I Diabetes
NCT01630850
Recruiting
The purpose of this study is to learn about the safety of islet transplantation for Type 1 diabetes mellitus, which may provide more normal control of blood sugar without the need for insulin shots. Islets are special clusters of cells within the pancreas that produce insulin. These cells will be obtained from cadaver (non-living) donors and given to subjects by vein.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/19/2024
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Diabetes Mellitus, Type 1
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Hematology Biobank : Invitro Study of Blood Disorders
NCT02442011
Recruiting
This is a bio repository of blood specimens from subjects with different Hematological disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Montefiore Medical Center, Bronx, New York
Conditions: Hematological Disorders
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A Single-Stage, Adaptive, Open-label, Dose Escalation Safety and Efficacy Study of AADC Deficiency in Pediatric Patients
NCT02852213
Recruiting
The overall objective of this study is to determine the safety and efficacy of AAV2-hAADC delivered to the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) in children with aromatic L-amino acid decarboxylase (AADC) deficiency.
Gender:
ALL
Ages:
24 months and above
Trial Updated:
12/19/2024
Locations: University of California San Francisco, Benioff Children's Hospital, San Francisco, California +2 locations
Conditions: AADC Deficiency
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PET Tau - Neurodegenerative Disease Imaging
NCT03143374
Recruiting
The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT). Tau has been shown to build up in the brains of patients with injury to brain cells. This study looks at neurodegenerative diseases such as frontotemporal degeneration (FTD).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/19/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Neurodegenerative Disease
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