Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery
NCT03493425
Recruiting
This randomized phase II trial studies how well chemotherapy before surgery and radiation therapy works compared to surgery and radiation therapy alone in treating patients with nasal and paranasal sinus cancer that can be removed by surgery. Drugs used in chemotherapy, such as docetaxel, cisplatin, and carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: University of Arizona Cancer Center-Orange Grove Campus, Tucson, Arizona +139 locations
Conditions: Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7, Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7
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Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
NCT03587272
Recruiting
This multisite prospective study seeks to determine if HLA-identical sibling donor transplantation using alemtuzumab, low dose total-body irradiation, and sirolimus (Sickle transplant Using a Nonmyeloablative approach, "SUN") can decrease the toxicity of transplant while achieving a high cure rate for children with sickle cell disease (SCD).
Gender:
ALL
Ages:
Between 2 years and 25 years
Trial Updated:
12/19/2024
Locations: Children's National Health System, Washington, District of Columbia +6 locations
Conditions: Sickle Cell Disease
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Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration
NCT04164641
Recruiting
Determining whether the utilization of Noraxon myoRESEARCH Software gait analysis Evaluation and orthotic gait Correction can reduce diabetic foot ulceration Or subsequent amputation in patients with a history of a diabetic foot ulceration.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
12/19/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Diabetic Foot Ulcer
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Cardiac Assessment by PV Loop in IPAH and Scleroderma PAH
NCT04610788
Recruiting
This observational study is being done to understand why people with scleroderma can develop pulmonary arterial hypertension (high blood pressure in the lungs, abbreviated PAH) and a weak heart muscle (heart failure). The study will also help the investigators understand why people with PAH from an unknown cause (called idiopathic PAH, or IPAH) can also develop a weakened heart muscle. The response of the right side of the heart or right ventricle (RV) to standard PAH therapy in scleroderma-asso... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/19/2024
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Scleroderma, Pulmonary Artery Hypertension
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Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
NCT04801771
Recruiting
This study is a prospective, single-arm study conducted under a common implant and follow-up protocol. The objective will be to follow fifty-seven (57) adolescents and young adults (10-21 years of age), with Down syndrome, moderate to severe sleep apnea, and post-adenotonsillectomy, for 12 months after undergoing implant of the Inspire Upper Airway Stimulation (UAS) System. The study is being conducted in order to evaluate objective change in cognition and expressive language after implant and t... Read More
Gender:
ALL
Ages:
Between 10 years and 21 years
Trial Updated:
12/19/2024
Locations: Children's Healthcare of Atlanta/ Emory University School of Medicine, Atlanta, Georgia +7 locations
Conditions: Down Syndrome, Obstructive Sleep Apnea
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Decreasing Cardiovascular Risk for Patients With Diabetes
NCT04874116
Recruiting
Cardiovascular disease (CVD) complications are the leading cause of diabetes mellitus (DM)-related morbidity and mortality, creating a significant burden on the public health system. This burden is, in part, attributable to poor medication adherence, with 21-42% of patients failing to properly adhere to their care. Importantly, this issue is especially pronounced in minority and low-income populations, which show higher rates of chronic illness and lower medication adherence. Interventions that... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Ingham Healthcare center, Lansing, Michigan
Conditions: Diabetes Mellitus, Type 2
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Diabetes Medical Nutrition Therapy in Southeastern African American Women
NCT04971889
Recruiting
A two-arm randomized controlled trial design will be used. Participants will include 291 African American women with type 2 diabetes that are at risk for development and/or progression of diabetes complications. Both arms, diabetes medical nutrition therapy (MNT) and diabetes MNT plus motivational interviewing (MI), will include: 1) a 3-month active intervention period of six biweekly (every other week), group-based, trained nutritionist-facilitated sessions; 2) a 3-month maintenance interventio... Read More
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
12/19/2024
Locations: Matthew Walker Comprehensive Health Center, Nashville, Tennessee +1 locations
Conditions: Type 2 Diabetes
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Antiseptic Effects on the Dental Implant Internal Surface Microbiome
NCT05024760
Recruiting
Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition o... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
12/19/2024
Locations: Madigan Army Medical Center, Tacoma, Washington
Conditions: Peri-Implantitis, Peri-implant Mucositis, Implant Infection, Dental Implant Failed
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MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence
NCT05106361
Recruiting
The purpose of this R34 exploratory research proposal is to conduct formative work for a larger randomized controlled trial (RCT) evaluating the effectiveness of the "Mother AdvocateS In the Community (MOSAIC) Plus" intervention to reduce depressive and PTSD symptoms and prevent additional IPV among pregnant women and mothers with children under 5 experiencing IPV. The MOSAIC Plus intervention will integrate IPT principles and skills into the MOSAIC intervention in order to expand it to address... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: YWCA Flint, Flint, Michigan
Conditions: Intimate Partner Violence, Depression, Post Traumatic Stress Disorder
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Care Transition Intervention for Hospitalized Patients with Advanced Cancer
NCT05142345
Recruiting
This study is examining whether a care transition intervention, CONTINUUM (CONTINUity of care Under Management by video visits), consisting of a supportive care-focused video visit with an oncology nurse practitioner (NP) within three business days of hospital discharge, may improve post-discharge transitions of care for recently hospitalized patients with advanced cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Cancer, Follow-Up Care, Consultation, Remote, Advanced Cancer
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Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors
NCT05145127
Recruiting
Study B7841007 is an open-label extension study to assess the long-term safety, tolerability, and efficacy of prophylaxis treatment with marstacimab in participants who did not require "Early Termination" from the Phase 3 Study B7841005 and from the Phase 3 Study B7841008. Study B7841005: approximately 145 adolescent and adult participants 12 to \<75 years of age with severe hemophilia A or moderately severe to severe hemophilia B (defined as FVIII activity \<1% or FIX activity ≤2%, respectivel... Read More
Gender:
MALE
Ages:
Between 1 year and 74 years
Trial Updated:
12/19/2024
Locations: University of Iowa, Iowa City, Iowa +59 locations
Conditions: Hemophilia A, Hemophilia B
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SURGE: Supporting UnderRepresented Minorities in Genomics-based Cancer Trial Enrollment (Intervention)
NCT05375643
Recruiting
SURGE aims to increase equity in clinical trial enrollment by addressing barriers to genomic testing, which is increasingly needed to assess precision clinical trial eligibility and access standard precision therapies. The study is an interventional pilot meant primarily to assess the feasibility of the intervention. The intervention is comprised of a patient navigator, text message questionnaire, and informational video.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts +2 locations
Conditions: Gastrointestinal Cancer, Thoracic Cancer, Hematologic Cancer
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