Lifestyle Patterns and Glycemic Control
NCT05224986
Recruiting
The goal of the proposed study is to evaluate the feasibility and initial efficacy of stabilizing lifestyle behaviors to improve glucose control and body composition in patients with pre-diabetes. The investigator proposes that following stable lifestyle behaviors will improve patients' glucose control, body composition, and liver fat. The results from this study has the potential to impact clinical practice and patient care.
Gender:
ALL
Ages:
25 years and above
Trial Updated:
08/14/2024
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Pre-diabetes
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Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
NCT06221852
Recruiting
This is a randomized, controlled clinical trial to assess the effects of the ketogenic diet in combination with treatment as usual on brain energy metabolism and psychiatric symptoms in individuals with first episode bipolar disorder and schizoaffective disorder.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
08/14/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Bipolar I Disorder, Psychosis, Schizoaffective Disorder
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Advanced Cooking Education Full Scale Study
NCT06558396
Recruiting
The aim of this study is to assess the impact of an in-person multi-component Advanced Cooking Education (ACE) 4-H after school program. The ACE Program consists of mindfulness, nutrition education, cooking labs, and professional development activities.
Gender:
ALL
Ages:
All
Trial Updated:
08/14/2024
Locations: Cornell University, Ithaca, New York
Conditions: Adolescent Behavior, Nutrition, Healthy
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Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers
NCT04205968
Recruiting
This phase II trial studies how well ramucirumab and paclitaxel or the FOLFIRI regimen (leucovorin calcium, fluorouracil, and irinotecan hydrochloride) work in treating patients with small bowel cancers that have spread extensively to other anatomic sites (advanced) or are no longer responding to treatment (refractory). Ramucirumab is a monoclonal antibody that attaches to and inhibits a molecule called VEGFR-2. This may restrain new blood vessel formation therefore reducing nutrient supply to t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +462 locations
Conditions: Metastatic Small Intestinal Adenocarcinoma, Stage III Small Intestinal Adenocarcinoma AJCC v8, Stage IIIA Small Intestinal Adenocarcinoma AJCC v8, Stage IIIB Small Intestinal Adenocarcinoma AJCC v8, Stage IV Small Intestinal Adenocarcinoma AJCC v8
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Pivotal Study of the CapsoCam Colon (CV-3) in Detecting Colonic Polyps, Using Colonoscopy as the Reference
NCT04607746
Recruiting
This study will evaluate the safety and effectiveness of the CapsoCam Colon (CV-3) endoscope system for the detection of colonic polyps.
Gender:
ALL
Ages:
Between 45 years and 75 years
Trial Updated:
08/14/2024
Locations: Gastro Care Institute, Lancaster, California +13 locations
Conditions: Colonic Polyp
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STEPS Implementation Trial
NCT05695885
Recruiting
This study will inform understanding of how to support emerging adults with autism spectrum disorder (ASD). The investigators will use a theoretically informed and research-based transition support program developed for people with ASD and test how effective it is when delivered by community agencies. Results will provide information on the effectiveness of the program as well as on mechanisms of change and contextual factors that promote or impede implementation.
Gender:
ALL
Ages:
Between 16 years and 25 years
Trial Updated:
08/14/2024
Locations: Center o=for Youth Development and Intervention, Tuscaloosa, Alabama
Conditions: Autism Spectrum Disorder
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The Role of Quantitative CT and Radiomic Biomarkers for Precision Medicine in Pulmonary Fibrosis
NCT06323876
Recruiting
This observational study involves obtaining 2 chest CT scans; a historical baseline CT within ±1 year of enrollment into PRECISIONS, and a follow-up CT (either historical or prospective) 12 months ± 180 days after the baseline CT. Many IPF patients will have a CT scan every 12 months for disease monitoring and cancer screening. Participants will have the option to share historical CTs only or they can choose to have a research CT done for the follow-up scan, if a scan for clinical purposes is no... Read More
Gender:
ALL
Ages:
Between 40 years and 101 years
Trial Updated:
08/14/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Idiopathic Pulmonary Fibrosis
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Local Cerebral Oxygenation in Chronic Pain Patients Utilizing Spinal Cord Stimulation
NCT06559735
Recruiting
The primary objective of the study is to determine changes in cerebral nociceptive hemodynamic response (blood oxygenation/flow) before, during and following spinal cord stimulation (SCS). Objective measurements of cerebral nociceptive hemodynamic responses will be obtained with the CereVu sensor and ROPA system and will be analyzed offline and compared against subjective measures of pain. Proprietary analysis algorithms will be incorporated and developed to understand how the objective measurem... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Boomerang Healthcare, Walnut Creek, California
Conditions: Chronic Pain
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Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric Adenocarcinoma
NCT04150640
Recruiting
This is an open label, phase II, multi-site trial evaluating the efficacy and safety of the combination of 5-FU, oxaliplatin, nal-IRI, and immunotherapy (plus trastuzumab for HER2-positive tumors) as first-line therapy for participants with advanced Esophageal and Gastric Adenocarcinoma (EGA). The investigators hypothesize that this drug combination will be better tolerated than current first-line chemotherapy combinations for this disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Esophageal Adenocarcinoma, Gastric Adenocarcinoma
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Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type
NCT05397639
Recruiting
This study will be conducted to evaluate the efficacy, safety, tolerability, and pharmacokinetics of masupirdine compared to placebo for the treatment of agitation in participants with dementia of the Alzheimer's type.
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
08/13/2024
Locations: Advanced Research Center, Inc., Anaheim, California +51 locations
Conditions: Agitation, Alzheimer's Type Dementia
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US National OCS Liver Perfusion (OLP) Registry
NCT05940857
Recruiting
This Registry is a sponsor-initiated, multi-center, observational, post-approval registry with an independent academic oversight. TransMedics has contracted with United Network for Organ Sharing (UNOS) the Federal manager of the U.S. national transplant outcomes registry to obtain data that is routinely collected by the Organ Procurement and Transplantation Network (OPTN) on all transplanted organs in the U.S. for both the OCS liver transplanted patients as well as patients transplanted using o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/13/2024
Locations: University of Alabama, Birmingham, Alabama +21 locations
Conditions: Liver Transplant
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Impact of Family-Centered Care for Intimate Partner Violence (IPV)
NCT06071299
Recruiting
The purpose of the study will be to determine how participation in Family-Centered Care (FCC) compared to Child-centered care (CCC) will affect caregiver engagement in IPV-based community services, caregiver perceptions of empowerment and survivor-defined practice, and clinical outcomes for children exposed to IPV.
Gender:
ALL
Ages:
3 years and below
Trial Updated:
08/13/2024
Locations: SCAN Clinic, Hartford, Connecticut +1 locations
Conditions: Intimate Partner Violence
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