Remote Ischemic Conditioning, Bimanual Skill Learning, and Corticospinal Excitability
NCT05355883
Recruiting
Unilateral cerebral palsy (UCP) is a leading cause of childhood disability. An early brain injury impairs the upper extremity function, bimanual coordination, and impacts the child's independence. The existing therapeutic interventions have higher training doses and modest effect sizes. Thus, there is a critical need to find an effective priming agent to enhance bimanual skill learning in children with UCP. This study aims to determine the effects of a novel priming agent, remote ischemic condit... Read More
Gender:
ALL
Ages:
Between 6 years and 16 years
Trial Updated:
08/08/2024
Locations: Dept. of Physical Therapy, East Carolina University, Greenville, North Carolina
Conditions: Unilateral Cerebral Palsy, Hemiplegic Cerebral Palsy, Remote Ischemic Conditioning
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Expressive Writing for Caregivers of Persons With Cancer
NCT05859880
Recruiting
The goal of this clinical trial is to test the effects of an expressive writing intervention for caregivers of persons with cancer. The main questions the study aims to answer are: 1. Does participation in a group-based, videoconference-delivered expressive writing intervention improve mood and quality of life for caregivers of persons with cancer? 2. Is greater improvement associated with writing that is more emotionally expressive or personally revealing, or with group-based sessions characte... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2024
Locations: Cancer Support Community Arizona, Phoenix, Arizona
Conditions: Quality of Life, Distress, Emotional
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Pharmacist-led Intervention for Injectable HIV Treatment for Women With Health-related Social Needs
NCT06411223
Recruiting
This study addresses real-world use of long-acting injectable cabotegravir/rilpivirine (CAB/RPV LA) by evaluating implementation and clinical outcomes of a pharmacist-led collaborative drug therapy management model (CDTM+) that will be expanded for telehealth outreach to women with health-related social needs (HRSN).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2024
Locations: Yale Clinical and Community Research, New Haven, Connecticut
Conditions: Hiv
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Capsule Endoscopy for Severe Hematochezia
NCT03616041
Recruiting
Patients with severe hematochezia (bright red blood per rectum) may have a bleeding source proximal to the colon. Visualization of the entire gastrointestinal tract using a second-generation colon capsule endoscopy system could improve diagnostic yields and form the basis for a new approach to early diagnosis that could change guidelines and practice management in these patients. The hypothesis of this study is that urgent colon capsule endoscopy will have higher rates of lesion localization and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2024
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California +1 locations
Conditions: Hematochezia
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Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
NCT04566328
Recruiting
This phase III trial compares the combination of four drugs (daratumumab, bortezomib, lenalidomide and dexamethasone) to the use of a three drug combination (daratumumab, lenalidomide and dexamethasone). Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spread... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2024
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +599 locations
Conditions: Plasma Cell Myeloma, RISS Stage I Plasma Cell Myeloma, RISS Stage II Plasma Cell Myeloma
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Immunotherapy Combined With Radiotherapy for Metastatic Sarcoma
NCT05488366
Recruiting
This is a pilot study determining the feasibility of combination treatments, pembrolizumab and stereotactic ablative radiotherapy (SBRT) in subjects with soft-tissue sarcoma. These are subjects who have metastatic disease initially, or recurrent or progressive disease that is not eligible for curative surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2024
Locations: Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California
Conditions: Sarcoma, Soft Tissue
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Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial
NCT05925634
Recruiting
The goal of this clinical trial is to compare two types of exercise prescriptions in cardiac rehabilitation eligible older adults (60 years or older) with heart disease. The investigators found in a single site pilot trial (insert NCTxxx) that one exercise prescription was better and are now repeating this study in a larger population at two sites (Baystate Medical Center, Springfield MA and Henry Ford Health System, Detroit MI). The main questions the investigators aim to answer are: 1. Compar... Read More
Gender:
ALL
Ages:
Between 60 years and 99 years
Trial Updated:
08/08/2024
Locations: Baystate Medical Center, Springfield, Massachusetts +1 locations
Conditions: Myocardial Infarction, Coronary Artery Bypass, Percutaneous Coronary Intervention, Heart Failure, Cardiac Valve Surgery
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Study of the Infectivity, Safety and Immunogenicity of Two Recombinant, Live-Attenuated, B/HPIV3 Vectored Vaccines Expressing the Fusion Glycoprotein of HMPV Delivered by Nasal Spray to HPIV3-Seropositive Children 24 to <60 Months of Age
NCT06546423
Recruiting
HPIV3 and HMPV are viruses that can cause breathing problems in children. The goal of this clinical trial is to look at the safety of 2 experimental HPIV3/HMPV vaccines in HPIV3-seropositive children ≥ 24 months to \< 60 months of age. Children will receive B/HPIV3/HMPV-PreF-A vaccine, B/HPIV3/HMPV-F-B365 vaccine, or placebo, and participants will not know which study product they have received. The main goals of the study are to find out whether these vaccines are well-tolerated and infectious... Read More
Gender:
ALL
Ages:
Between 24 months and 59 months
Trial Updated:
08/08/2024
Locations: CIR - Rangos, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland +3 locations
Conditions: Human Metapneumovirus, Human Parainfluenza Virus Type 3
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Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
NCT00181259
Recruiting
The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: Johns Hopkins Medical Institutions, Baltimore, Maryland
Conditions: Heart Failure, Congestive
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A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment
NCT05189223
Recruiting
The US Veteran community continues to feel the impact of the overdose crisis, and opioid use disorder (OUD) diagnoses among Veterans continue to rise. Medication treatment (e.g., buprenorphine, methadone, naltrexone) helps prevent relapse and reduce overdose risk, but does not help with the psychological, social, and functional challenges of early recovery. Therapies that focus on interpersonal functioning and community integration may help improve quality of life during this high-risk period. T... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: VA Bedford HealthCare System, Bedford, MA, Bedford, Massachusetts
Conditions: Dependence, Opioid
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Uterus Transplantation to Treat Infertility
NCT05646992
Recruiting
This research study will use uterus transplantation to treat uterine factor infertility, also known as the inability to bear children due to not having a uterus. The purpose of this study is to enable women seeking genetically-related children and the childbearing experience to experience pregnancy and birth a child. In this study, living donors will undergo surgery to give the donor's uterus to another woman. The woman who receives the transplant will take immunosuppression to keep the uterus a... Read More
Gender:
FEMALE
Ages:
Between 18 years and 38 years
Trial Updated:
08/07/2024
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Uterine Factor Infertility
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Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients
NCT05988658
Recruiting
The study's objective is to evaluate the additive value of renal biomarkers (from blood and urine) for identifying individuals at high risk for severe acute kidney injury (AKI) above that of a novel natural language processing (NLP)-based AKI risk algorithm. The risk algorithm is based on electronic health records (EHR) data (labs, vitals, clinical notes, and test reports). Patients will enroll at the University of Chicago Medical Center and the University of Wisconsin Hospital, where the risk s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: University of Chicago Medical Center, Chicago, Illinois +1 locations
Conditions: Acute Kidney Injury, Biomarkers
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