Pedal Pump and Leg Lymphedema
Recruiting
Chronic lymphedema in the lower extremities is a common problem found in older adults that can result in cellulitis, poor wound healing, venous stasis ulcers, and other comorbidities. Compressive therapies are the present gold standard for the manual treatment of lymphedema in the lower extremities. However, the benefits of these compressive therapies are modest, and they are not well tolerated by older adults. An alternative manual treatment is the osteopathic pedal pump, an osteopathic manipul... Read More
Gender:
ALL
Ages:
Between 55 years and 100 years
Trial Updated:
11/14/2024
Locations: Rowan University School of Osteopathic Medicine, Stratford, New Jersey
Conditions: Lymphedema
Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect
Recruiting
The primary purpose of this substudy is to determine if collagen-targeted PET using the type 1 collagen-targeted PET probe, Gallium-68 (68Ga)-labeled collagen binding probe 8 (CBP8) can inform as to drug effect of EGCG and assist in dose selection.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
11/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Idiopathic Pulmonary Fibrosis
Comparison of Cryoablation of Pericapsular Nerve Group (PENG) to Fascia Iliaca Catheter in Patients With a Hip Fracture
Recruiting
The purpose of this study is to determine if patients with hip fractures who undergo cryoablation of the PENG have improved pain control 30 days from surgery when compared to those who have a fascia iliaca catheter.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/14/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Hip Fractures
Pemigatinib + Afatinib in Advanced Refractory Solid Tumors
Recruiting
This study is researching whether the combination of Afatinib and Pemigatinib is safe and effective in FGFR altered unresectable or metastatic advanced solid tumors. The study is also trying to discover the highest doses of the study drugs that can be administered without causing any intolerable side effects. This research study involves the study drugs Afatinib and Pemigatinib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Advanced Solid Tumor, Unresectable Solid Tumor, Metastatic Solid Tumor, Cholangiocarcinoma
Testing an Accelerated TMS Protocol for Methamphetamine Use Disorder
Recruiting
The investigators will evaluate the effects of an accelerated Transcranial Magnetic Stimulation (TMS) protocol of the left dorsolateral prefrontal cortex (DLPFC) for moderate to severe methamphetamine use disorder. This is a randomized parallel group design to assess feasibility and safety, evaluate efficacy (use, craving) and identify magnetic resonance imaging (resting state and cue craving) associated with group/outcomes.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
11/14/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Methamphetamine Use Disorder
CHW Intervention to Improve Nutrition Security of Patients with Hypertension
Recruiting
The goal of this study is to implement and evaluate a randomized pilot study of a 4-month Nutrition-enhanced community health worker (CHW) intervention for primary care patients with nutrition insecurity and poorly controlled hypertension. The nutrition intervention will be added to the pre-existing Massachusetts General Hospital CHW hypertension (Basic CHW) program that provides hypertension education, coaching about adherence to medications and primary care visits, and home BP cuffs and promot... Read More
Gender:
ALL
Ages:
Between 21 years and 99 years
Trial Updated:
11/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypertension, Nutrition, Healthy, Food Insecurity, Community Health Worker
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
Recruiting
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training" (RS-tDCS+) which has shown promise for improving complex attention in both healthy and clinical populations. RS-tDCS+ is a home-based, low-risk, non-invasive technique that is designed to boost cognitive training by enhancing learning and the brain's ability to reorganize conne... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/14/2024
Locations: Naval Medical Center San Diego, San Diego, California +1 locations
Conditions: Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment, Post Concussive Symptoms
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
Recruiting
This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes which are often over-expressed in a variety of tumor cell types. This may help stop or slow the growth... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Mercy Hospital Fort Smith, Fort Smith, Arkansas +111 locations
Conditions: Refractory Differentiated Thyroid Gland Carcinoma
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
Recruiting
The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new treatments for heart failure.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
11/14/2024
Locations: Northwestern University, Chicago, Illinois +5 locations
Conditions: Heart Failure, Heart Failure With Preserved Ejection Fraction
CD34+ Selected Stem Cell for Poor Graft Function or Graft Failure
Recruiting
The proposed trial is a single arm, non-randomized, single center pilot study utilizing CliniMACS CD34 Reagent System for patients following allogeneic hematopoietic stem cell transplant (HSCT) requiring treatment of graft dysfunction or failure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: NYU Langone Health, New York, New York
Conditions: Graft Failure, Poor Graft Function
Elranatamab in Patients with Relapsed or Refractory AL Amyloidosis
Recruiting
This study will evaluate the safety, tolerability and efficacy of elranatamab in patients with relapsed or refractory AL amyloidosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: AL Amyloidosis
A Multi-Country Observational Study of Safety and Effectiveness of Elfabrio® in Fabry Patients
Recruiting
A multi-centre, multi-country, observational, non-interventional, retrospective and prospective (hybrid) study among Fabry disease participants treated with pegunigalsidase alfa (Elfabrio®) in routine clinical care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Infusion Associates, Grand Rapids, Michigan
Conditions: Fabry Disease